Proline-rich protein 24
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028334 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Proline-rich protein 24 vs. Ensembl Human
Match: INAFM2 (InaF motif containing 2 [Source:HGNC Symbol;Acc:HGNC:35165]) HSP 1 Score: 54.6842 bits (130), Expect = 1.040e-9 Identity = 22/31 (70.97%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+RLATV Y++ VSLAAIVLA+YYS+IW P Sbjct: 33 WVRLATVFAYVLSVSLAAIVLAVYYSLIWQP 63
BLAST of Proline-rich protein 24 vs. Ensembl Human
Match: INAFM1 (InaF motif containing 1 [Source:HGNC Symbol;Acc:HGNC:27406]) HSP 1 Score: 48.521 bits (114), Expect = 1.715e-7 Identity = 19/32 (59.38%), Postives = 24/32 (75.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPN 299 WLRLA V Y + VSLAA++LA+YY +IW P Sbjct: 27 WLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPT 58
BLAST of Proline-rich protein 24 vs. Ensembl Zebrafish
Match: zgc:153157 (zgc:153157 [Source:ZFIN;Acc:ZDB-GENE-060825-224]) HSP 1 Score: 54.299 bits (129), Expect = 2.997e-9 Identity = 23/35 (65.71%), Postives = 28/35 (80.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKS 308 W+RLATV Y++ VSLAAI+LAIYYS+IW P S Sbjct: 25 WVRLATVFAYVLSVSLAAIILAIYYSLIWKPTSAS 59
BLAST of Proline-rich protein 24 vs. Ensembl Zebrafish
Match: zgc:153157 (zgc:153157 [Source:ZFIN;Acc:ZDB-GENE-060825-224]) HSP 1 Score: 54.299 bits (129), Expect = 2.997e-9 Identity = 23/35 (65.71%), Postives = 28/35 (80.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKS 308 W+RLATV Y++ VSLAAI+LAIYYS+IW P S Sbjct: 25 WVRLATVFAYVLSVSLAAIILAIYYSLIWKPTSAS 59
BLAST of Proline-rich protein 24 vs. Ensembl Zebrafish
Match: zgc:153157 (zgc:153157 [Source:ZFIN;Acc:ZDB-GENE-060825-224]) HSP 1 Score: 54.299 bits (129), Expect = 3.118e-9 Identity = 23/35 (65.71%), Postives = 28/35 (80.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKS 308 W+RLATV Y++ VSLAAI+LAIYYS+IW P S Sbjct: 34 WVRLATVFAYVLSVSLAAIILAIYYSLIWKPTSAS 68
BLAST of Proline-rich protein 24 vs. Ensembl Xenopus
Match: ap4e1 (adaptor related protein complex 4 subunit epsilon 1 [Source:Xenbase;Acc:XB-GENE-988221]) HSP 1 Score: 51.2174 bits (121), Expect = 1.661e-8 Identity = 21/31 (67.74%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+RLATV Y++ VS+AAI+LAIYYS+IW P Sbjct: 34 WVRLATVFAYVLSVSMAAIILAIYYSLIWMP 64
BLAST of Proline-rich protein 24 vs. Ensembl Mouse
Match: Inafm2 (InaF motif containing 2 [Source:MGI Symbol;Acc:MGI:1915354]) HSP 1 Score: 54.6842 bits (130), Expect = 7.318e-10 Identity = 22/31 (70.97%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+RLATV Y++ VSLAAIVLA+YYS+IW P Sbjct: 33 WVRLATVFAYVLSVSLAAIVLAVYYSLIWQP 63
BLAST of Proline-rich protein 24 vs. Ensembl Mouse
Match: Inafm1 (InaF motif containing 1 [Source:MGI Symbol;Acc:MGI:1913550]) HSP 1 Score: 48.1358 bits (113), Expect = 1.731e-7 Identity = 19/32 (59.38%), Postives = 24/32 (75.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPN 299 WLRLA V Y + VSLAA++LA+YY +IW P Sbjct: 27 WLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPT 58
BLAST of Proline-rich protein 24 vs. UniProt/SwissProt
Match: sp|P0DMQ5|INAM2_HUMAN (Putative transmembrane protein INAFM2 OS=Homo sapiens OX=9606 GN=INAFM2 PE=2 SV=1) HSP 1 Score: 54.6842 bits (130), Expect = 4.993e-9 Identity = 22/31 (70.97%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+RLATV Y++ VSLAAIVLA+YYS+IW P Sbjct: 33 WVRLATVFAYVLSVSLAAIVLAVYYSLIWQP 63
BLAST of Proline-rich protein 24 vs. UniProt/SwissProt
Match: sp|C9JVW0|INAM1_HUMAN (Putative transmembrane protein INAFM1 OS=Homo sapiens OX=9606 GN=INAFM1 PE=4 SV=1) HSP 1 Score: 48.521 bits (114), Expect = 8.237e-7 Identity = 19/32 (59.38%), Postives = 24/32 (75.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPN 299 WLRLA V Y + VSLAA++LA+YY +IW P Sbjct: 27 WLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPT 58
BLAST of Proline-rich protein 24 vs. TrEMBL
Match: A0A068WMV8 (Uncharacterized protein OS=Echinococcus granulosus OX=6210 GN=EgrG_000429500 PE=4 SV=1) HSP 1 Score: 58.9214 bits (141), Expect = 7.004e-9 Identity = 26/36 (72.22%), Postives = 30/36 (83.33%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKSH 311 WLRLATV +Y+I VSLAAIVLAIYYSI W P + S+ Sbjct: 33 WLRLATVFVYVISVSLAAIVLAIYYSIFWKPTISSN 68
BLAST of Proline-rich protein 24 vs. TrEMBL
Match: A0A068XXD0 (Uncharacterized protein OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000429500 PE=4 SV=1) HSP 1 Score: 58.9214 bits (141), Expect = 7.472e-9 Identity = 26/36 (72.22%), Postives = 30/36 (83.33%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKSH 311 WLRLATV +Y+I VSLAAIVLAIYYSI W P + S+ Sbjct: 33 WLRLATVFVYVISVSLAAIVLAIYYSIFWKPTISSN 68
BLAST of Proline-rich protein 24 vs. TrEMBL
Match: A0A0R3UII8 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS7244 PE=4 SV=1) HSP 1 Score: 56.9954 bits (136), Expect = 4.023e-8 Identity = 25/36 (69.44%), Postives = 30/36 (83.33%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKSH 311 W+RLATV +Y+I VSLAAIVLAIYYSI W P + S+ Sbjct: 33 WVRLATVFVYVISVSLAAIVLAIYYSIFWKPTISSN 68
BLAST of Proline-rich protein 24 vs. TrEMBL
Match: A0A0L8FMF0 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22014942mg PE=4 SV=1) HSP 1 Score: 56.225 bits (134), Expect = 1.195e-7 Identity = 23/35 (65.71%), Postives = 31/35 (88.57%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKS 308 W+RLATV+ Y++ VSLAAIVLAIYYS++W P +K+ Sbjct: 41 WVRLATVLAYVLAVSLAAIVLAIYYSLLWKPELKT 75
BLAST of Proline-rich protein 24 vs. TrEMBL
Match: A0A2R2MLY4 (putative transmembrane protein INAFM2 OS=Lingula unguis OX=7574 GN=LOC112041796 PE=4 SV=1) HSP 1 Score: 56.9954 bits (136), Expect = 1.335e-7 Identity = 23/34 (67.65%), Postives = 31/34 (91.18%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVK 305 W+RLATV+ YI+ VSLAAIVLAIYYS++W P+++ Sbjct: 37 WVRLATVLAYILAVSLAAIVLAIYYSVLWKPDLQ 70
BLAST of Proline-rich protein 24 vs. Ensembl Cavefish
Match: ENSAMXT00000054091.1 (pep primary_assembly:Astyanax_mexicanus-2.0:3:57405720:57409823:1 gene:ENSAMXG00000037096.1 transcript:ENSAMXT00000054091.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 52.7582 bits (125), Expect = 3.327e-9 Identity = 23/35 (65.71%), Postives = 28/35 (80.00%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKS 308 W+RLATV Y++ VSLAAI+LAIYYS+IW P S Sbjct: 28 WVRLATVFAYVLSVSLAAIILAIYYSLIWKPTSAS 62
BLAST of Proline-rich protein 24 vs. Ensembl Cavefish
Match: INAFM2 (InaF motif containing 2 [Source:HGNC Symbol;Acc:HGNC:35165]) HSP 1 Score: 50.447 bits (119), Expect = 1.942e-8 Identity = 21/31 (67.74%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+RLATV Y++ VSLAAI+LA+YYS+IW P Sbjct: 36 WVRLATVFAYVLSVSLAAIILAVYYSLIWKP 66
BLAST of Proline-rich protein 24 vs. Ensembl Medaka
Match: INAFM2 (InaF motif containing 2 [Source:NCBI gene;Acc:101154992]) HSP 1 Score: 53.5286 bits (127), Expect = 3.152e-9 Identity = 22/31 (70.97%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+RLATV Y++ VSLAAI+LAIYYS+IW P Sbjct: 34 WVRLATVFAYVLSVSLAAIILAIYYSLIWKP 64
BLAST of Proline-rich protein 24 vs. Ensembl Medaka
Match: ENSORLT00000019708.2 (pep primary_assembly:ASM223467v1:24:12057671:12063197:-1 gene:ENSORLG00000015736.2 transcript:ENSORLT00000019708.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 50.447 bits (119), Expect = 4.841e-8 Identity = 19/31 (61.29%), Postives = 27/31 (87.10%), Query Frame = 3 Query: 204 WLRLATVMIYIILVSLAAIVLAIYYSIIWHP 296 W+R+ TV+ Y++ VS+AAIVLA+YYS+IW P Sbjct: 33 WVRVLTVLAYVLAVSVAAIVLAVYYSLIWEP 63
BLAST of Proline-rich protein 24 vs. Planmine SMEST
Match: SMESG000002898.1 (SMESG000002898.1) HSP 1 Score: 156.377 bits (394), Expect = 1.168e-50 Identity = 90/90 (100.00%), Postives = 90/90 (100.00%), Query Frame = 3 Query: 42 MFEKEMEYRLDQSFNEQNDPSNIQEDTTQCLLKRFNAETEXXXXXXXXXXXXXXWLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKSH 311 MFEKEMEYRLDQSFNEQNDPSNIQEDTTQCLLKRFNAETENISKKTNLKSNNKKWLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKSH Sbjct: 1 MFEKEMEYRLDQSFNEQNDPSNIQEDTTQCLLKRFNAETENISKKTNLKSNNKKWLRLATVMIYIILVSLAAIVLAIYYSIIWHPNVKSH 90 The following BLAST results are available for this feature:
BLAST of Proline-rich protein 24 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 2
BLAST of Proline-rich protein 24 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Proline-rich protein 24 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Proline-rich protein 24 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of Proline-rich protein 24 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Proline-rich protein 24 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of Proline-rich protein 24 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 2
BLAST of Proline-rich protein 24 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Proline-rich protein 24 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Proline-rich protein 24 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Proline-rich protein 24 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Proline-rich protein 24 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Proline-rich protein 24 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of Proline-rich protein 24 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028334 ID=SMED30028334|Name=Proline-rich protein 24|organism=Schmidtea mediterranea sexual|type=transcript|length=410bpback to top protein sequence of SMED30028334-orf-1 >SMED30028334-orf-1 ID=SMED30028334-orf-1|Name=SMED30028334-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=104bp VRRSYRNLYKSYMMFEKEMEYRLDQSFNEQNDPSNIQEDTTQCLLKRFNAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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