WW domain-containing protein

Overview


Name	WW domain-containing protein
Smed ID	SMED30028310
Length (bp)	3774

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of WW domain-containing protein (SMED30028310) t-SNE clustered cells

Violin plots show distribution of expression levels for WW domain-containing protein (SMED30028310) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of WW domain-containing protein (SMED30028310) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for WW domain-containing protein (SMED30028310) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30028310

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30028310	SMESG000049121.1	SmedASXL_015755	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30028310	SMESG000049121.1	SmedASXL_015755	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X1 cell	SMED30028310	SMESG000049121.1	SmedASXL_017637	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30028310	SMESG000049121.1	SmedASXL_017637	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
neoblast	SMED30028310	SMESG000049121.1	dd_Smed_v4_7846_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of WW domain-containing protein vs. Ensembl Human
Match: SETD2 (SET domain containing 2, histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:18420])

HSP 1 Score: 89.3521 bits (220), Expect = 4.116e-17
Identity = 60/189 (31.75%), Postives = 93/189 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH +T+  QW+ P   WE   D      D +L  E ++   ++     + N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I T ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +YK
Sbjct: 2391 LPPNW---KTARDPEGKIYYYHVITRQTQWDPPT--WESPGD------DASLEHEAEM---DLGTPTYDENPMKASKKPKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPED-LECNENVKHKTKEYIKKYMQKFGAVYK 2556

[Close]

BLAST of WW domain-containing protein vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234])

HSP 1 Score: 55.0694 bits (131), Expect = 1.229e-6
Identity = 48/183 (26.23%), Postives = 72/183 (39.34%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-------IKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C+ T  NP         C     CI   L  EC    CP    C N  F        +   +E F  +     W +RTK  I+K + + E   +GE+      E E      +  +H       + +D  R  D     +Y R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1897 CKATDENP---------CGIDSECINRMLLYECHPTVCPAGGRCQNQCF-----SKRQYPEVEIFRTLQRG--WGLRTKTDIKKGEFVNEY--VGELI----DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 2057

[Close]

BLAST of WW domain-containing protein vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234])

HSP 1 Score: 54.6842 bits (130), Expect = 1.440e-6
Identity = 48/183 (26.23%), Postives = 72/183 (39.34%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-------IKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C+ T  NP         C     CI   L  EC    CP    C N  F        +   +E F  +     W +RTK  I+K + + E   +GE+      E E      +  +H       + +D  R  D     +Y R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1628 CKATDENP---------CGIDSECINRMLLYECHPTVCPAGGRCQNQCF-----SKRQYPEVEIFRTLQRG--WGLRTKTDIKKGEFVNEY--VGELI----DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 1788

[Close]

BLAST of WW domain-containing protein vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234])

HSP 1 Score: 54.6842 bits (130), Expect = 1.440e-6
Identity = 48/183 (26.23%), Postives = 72/183 (39.34%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-------IKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C+ T  NP         C     CI   L  EC    CP    C N  F        +   +E F  +     W +RTK  I+K + + E   +GE+      E E      +  +H       + +D  R  D     +Y R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1628 CKATDENP---------CGIDSECINRMLLYECHPTVCPAGGRCQNQCF-----SKRQYPEVEIFRTLQRG--WGLRTKTDIKKGEFVNEY--VGELI----DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 1788

[Close]

BLAST of WW domain-containing protein vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0301559)

HSP 1 Score: 67.3958 bits (163), Expect = 1.134e-10
Identity = 37/118 (31.36%), Postives = 66/118 (55.93%), Query Frame = 2

Query: 3302 EMKQKKLQVTKANV-AKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVH 3652
            E + KK++ +++ + A   +E+ E      F+ +I   +A+ LRPYR   C+ G+I +DED  +L N+LS  I  KE++      + L  T  V+ K+  ++  YM+ +G +YK+P  
Sbjct: 2199 EQRSKKVKSSQSPLTATSAREAHEK-----FRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRYCEVSGNPLSCTESVKHKSYDFINQYMRQKGPVYKKPAE 2311

[Close]

BLAST of WW domain-containing protein vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0073779)

HSP 1 Score: 67.0106 bits (162), Expect = 1.176e-10
Identity = 37/118 (31.36%), Postives = 66/118 (55.93%), Query Frame = 2

Query: 3302 EMKQKKLQVTKANV-AKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVH 3652
            E + KK++ +++ + A   +E+ E      F+ +I   +A+ LRPYR   C+ G+I +DED  +L N+LS  I  KE++      + L  T  V+ K+  ++  YM+ +G +YK+P  
Sbjct: 2248 EQRSKKVKSSQSPLTATSAREAHEK-----FRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRYCEVSGNPLSCTESVKHKSYDFINQYMRQKGPVYKKPAE 2360

[Close]

BLAST of WW domain-containing protein vs. Ensembl Zebrafish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-030131-2140])

HSP 1 Score: 84.3445 bits (207), Expect = 9.129e-16
Identity = 56/190 (29.47%), Postives = 88/190 (46.32%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNL--NNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + R+++YH +T+  QW+ P   W+G  +            E  V H+    +       N  +   K  +  T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2523 LPPSW---KVARDPEGRIYYYHIITRQTQWDPPS--WDGTTE------------EASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPED-LECNENVKHKTKEYIKKYMQKFGSVYR 2686

[Close]

BLAST of WW domain-containing protein vs. Ensembl Zebrafish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-030131-2140])

HSP 1 Score: 84.3445 bits (207), Expect = 9.789e-16
Identity = 56/190 (29.47%), Postives = 88/190 (46.32%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNL--NNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + R+++YH +T+  QW+ P   W+G  +            E  V H+    +       N  +   K  +  T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2564 LPPSW---KVARDPEGRIYYYHIITRQTQWDPPS--WDGTTE------------EASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPED-LECNENVKHKTKEYIKKYMQKFGSVYR 2727

[Close]

BLAST of WW domain-containing protein vs. Ensembl Zebrafish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-030131-2140])

HSP 1 Score: 84.3445 bits (207), Expect = 1.004e-15
Identity = 56/190 (29.47%), Postives = 88/190 (46.32%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNL--NNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + R+++YH +T+  QW+ P   W+G  +            E  V H+    +       N  +   K  +  T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2566 LPPSW---KVARDPEGRIYYYHIITRQTQWDPPS--WDGTTE------------EASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPED-LECNENVKHKTKEYIKKYMQKFGSVYR 2729

[Close]

BLAST of WW domain-containing protein vs. Ensembl Zebrafish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-030131-2140])

HSP 1 Score: 82.4185 bits (202), Expect = 3.254e-15
Identity = 55/187 (29.41%), Postives = 88/187 (47.06%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + R+++YH +T+  QW+ P   W+G  +          + E +   D     Y    + +  K  +   T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2479 LPPSW---KVARDPEGRIYYYHIITRQTQWDPP--SWDGTTEEA--------SVEHEAEMDLGTPTYDENPSKFSTKTAEAD-TSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPED-LECNENVKHKTKEYIKKYMQKFGSVYR 2642

[Close]

BLAST of WW domain-containing protein vs. Ensembl Xenopus
Match: macroh2a1 (macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855803])

HSP 1 Score: 82.0333 bits (201), Expect = 7.687e-15
Identity = 57/190 (30.00%), Postives = 92/190 (48.42%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELE-IYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LP  W   + A   + ++++YH +T+  QW+ P +   G +   LE   + +L +    ++DE        N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D L+    V+ KTK Y+K YMQ  G +YK
Sbjct: 2797 LPSGW---KTARDPEGKIYYYHVITRQTQWDPPAWDSPGEEGGALEHEAEMDLGT---PTYDE--------NPMKSSKKTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKMGRINNTEDFKHLARKLTHGVMNKELKYCKNPED-LDCNENVKHKTKEYIKKYMQKFGTVYK 2963

[Close]

BLAST of WW domain-containing protein vs. Ensembl Xenopus
Match: macroh2a1 (macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855803])

HSP 1 Score: 81.6481 bits (200), Expect = 8.475e-15
Identity = 57/190 (30.00%), Postives = 92/190 (48.42%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELE-IYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LP  W   + A   + ++++YH +T+  QW+ P +   G +   LE   + +L +    ++DE        N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D L+    V+ KTK Y+K YMQ  G +YK
Sbjct: 2043 LPSGW---KTARDPEGKIYYYHVITRQTQWDPPAWDSPGEEGGALEHEAEMDLGT---PTYDE--------NPMKSSKKTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKMGRINNTEDFKHLARKLTHGVMNKELKYCKNPED-LDCNENVKHKTKEYIKKYMQKFGTVYK 2209

[Close]

BLAST of WW domain-containing protein vs. Ensembl Xenopus
Match: macroh2a1 (macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855803])

HSP 1 Score: 81.6481 bits (200), Expect = 9.686e-15
Identity = 54/189 (28.57%), Postives = 87/189 (46.03%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LP  W   + A   + ++++YH +T+  QW+ P +   G +   LE             H+    +     +   MK+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D L+    V+ KTK Y+K YMQ  G +YK
Sbjct: 2528 LPSGW---KTARDPEGKIYYYHVITRQTQWDPPAWDSPGEEGGALE-------------HEAEMDLGTPTYDENPMKKTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKMGRINNTEDFKHLARKLTHGVMNKELKYCKNPED-LDCNENVKHKTKEYIKKYMQKFGTVYK 2691

[Close]

BLAST of WW domain-containing protein vs. Ensembl Xenopus
Match: macroh2a1 (macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855803])

HSP 1 Score: 81.6481 bits (200), Expect = 9.786e-15
Identity = 54/189 (28.57%), Postives = 87/189 (46.03%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LP  W   + A   + ++++YH +T+  QW+ P +   G +   LE             H+    +     +   MK+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D L+    V+ KTK Y+K YMQ  G +YK
Sbjct: 2563 LPSGW---KTARDPEGKIYYYHVITRQTQWDPPAWDSPGEEGGALE-------------HEAEMDLGTPTYDENPMKKTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKMGRINNTEDFKHLARKLTHGVMNKELKYCKNPED-LDCNENVKHKTKEYIKKYMQKFGTVYK 2726

[Close]

BLAST of WW domain-containing protein vs. Ensembl Mouse
Match: Setd2 (SET domain containing 2 [Source:MGI Symbol;Acc:MGI:1918177])

HSP 1 Score: 89.3521 bits (220), Expect = 2.942e-17
Identity = 60/189 (31.75%), Postives = 93/189 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH +T+  QW+ P   WE   D      D +L  E ++   ++     + N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I T ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +YK
Sbjct: 2364 LPPNW---KTARDPEGKIYYYHVITRQTQWDPPT--WESPGD------DASLEHEAEM---DLGTPTYDENPMKTSKKPKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPED-LECNENVKHKTKEYIKKYMQKFGAVYK 2529

[Close]

BLAST of WW domain-containing protein vs. Ensembl Mouse
Match: Setd2 (SET domain containing 2 [Source:MGI Symbol;Acc:MGI:1918177])

HSP 1 Score: 88.1965 bits (217), Expect = 3.957e-17
Identity = 60/189 (31.75%), Postives = 93/189 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH +T+  QW+ P   WE   D      D +L  E ++   ++     + N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I T ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +YK
Sbjct:  587 LPPNW---KTARDPEGKIYYYHVITRQTQWDPPT--WESPGD------DASLEHEAEM---DLGTPTYDENPMKTSKKPKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPED-LECNENVKHKTKEYIKKYMQKFGAVYK 752

[Close]

BLAST of WW domain-containing protein vs. Ensembl Mouse
Match: Nsd1 (nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545])

HSP 1 Score: 54.6842 bits (130), Expect = 1.129e-6
Identity = 48/183 (26.23%), Postives = 73/183 (39.89%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-------IKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C+ T  NP         C     CI   L  EC    CP    C N  F        +  ++E F  +     W +RTK  I+K + + E   +GE+      E E      +  +H       + +D  R  D     +Y R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1795 CKATDENP---------CGIDSECINRMLLYECHPTVCPAGVRCQNQCF-----SKRQYPDVEIFRTLQRG--WGLRTKTDIKKGEFVNEY--VGELI----DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 1955

[Close]

BLAST of WW domain-containing protein vs. Ensembl Mouse
Match: Nsd1 (nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545])

HSP 1 Score: 54.299 bits (129), Expect = 1.264e-6
Identity = 48/183 (26.23%), Postives = 73/183 (39.89%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-------IKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C+ T  NP         C     CI   L  EC    CP    C N  F        +  ++E F  +     W +RTK  I+K + + E   +GE+      E E      +  +H       + +D  R  D     +Y R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1898 CKATDENP---------CGIDSECINRMLLYECHPTVCPAGVRCQNQCF-----SKRQYPDVEIFRTLQRG--WGLRTKTDIKKGEFVNEY--VGELI----DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 2058

[Close]

BLAST of WW domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9BYW2|SETD2_HUMAN (Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3)

HSP 1 Score: 89.3521 bits (220), Expect = 1.977e-16
Identity = 60/189 (31.75%), Postives = 93/189 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH +T+  QW+ P   WE   D      D +L  E ++   ++     + N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I T ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +YK
Sbjct: 2391 LPPNW---KTARDPEGKIYYYHVITRQTQWDPPT--WESPGD------DASLEHEAEM---DLGTPTYDENPMKASKKPKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPED-LECNENVKHKTKEYIKKYMQKFGAVYK 2556

[Close]

BLAST of WW domain-containing protein vs. UniProt/SwissProt
Match: sp|E9Q5F9|SETD2_MOUSE (Histone-lysine N-methyltransferase SETD2 OS=Mus musculus OX=10090 GN=Setd2 PE=1 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 2.058e-16
Identity = 60/189 (31.75%), Postives = 93/189 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQV--TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH +T+  QW+ P   WE   D      D +L  E ++   ++     + N M   K+ K     T + +AK+ KE        +F++++   I   L PYR   C  G+I T ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +YK
Sbjct: 2364 LPPNW---KTARDPEGKIYYYHVITRQTQWDPPT--WESPGD------DASLEHEAEM---DLGTPTYDENPMKTSKKPKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPED-LECNENVKHKTKEYIKKYMQKFGAVYK 2529

[Close]

BLAST of WW domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9VYD1|C1716_DROME (Probable histone-lysine N-methyltransferase CG1716 OS=Drosophila melanogaster OX=7227 GN=Set2 PE=1 SV=2)

HSP 1 Score: 66.2402 bits (160), Expect = 2.194e-9
Identity = 37/118 (31.36%), Postives = 66/118 (55.93%), Query Frame = 2

Query: 3302 EMKQKKLQVTKANV-AKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVH 3652
            E + KK++ +++ + A   +E+ E      F+ +I   +A+ LRPYR   C+ G+I +DED  +L N+LS  I  KE++      + L  T  V+ K+  ++  YM+ +G +YK+P  
Sbjct: 2199 EQRSKKVKSSQSPLTATSAREAHEK-----FRFEISGHVANFLRPYRKESCTLGRITSDEDYKFLVNRLSYHITTKEMRYCEVSGNPLSCTESVKHKSYDFINQYMRQKGPVYKKPAE 2311

[Close]

BLAST of WW domain-containing protein vs. UniProt/SwissProt
Match: sp|Q96L73|NSD1_HUMAN (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1)

HSP 1 Score: 55.0694 bits (131), Expect = 5.900e-6
Identity = 48/183 (26.23%), Postives = 72/183 (39.34%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-------IKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C+ T  NP         C     CI   L  EC    CP    C N  F        +   +E F  +     W +RTK  I+K + + E   +GE+      E E      +  +H       + +D  R  D     +Y R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1897 CKATDENP---------CGIDSECINRMLLYECHPTVCPAGGRCQNQCF-----SKRQYPEVEIFRTLQRG--WGLRTKTDIKKGEFVNEY--VGELI----DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFN 2057

[Close]

BLAST of WW domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2LAE1|ASHH2_ARATH (Histone-lysine N-methyltransferase ASHH2 OS=Arabidopsis thaliana OX=3702 GN=ASHH2 PE=1 SV=1)

HSP 1 Score: 54.6842 bits (130), Expect = 6.887e-6
Identity = 46/200 (23.00%), Postives = 85/200 (42.50%), Query Frame = 2

Query: 1784 SVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKH-----IKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLL 2368
            ++  N+ + ++   +     M C C  P+PD    G   C  G+ C+   L IEC    CP   LC N QF        K + ++F         + +R  + +++ + + E   +GE+   + +E      +    KH     +  +   D  +  +  R+     + N   EKW+  G   +GIF+++DL+ G+EL  
Sbjct:  957 AIKTNQFLHRNRKSQTIDEIMVCHCK-PSPD----GRLGC--GEECLNRMLNIECLQGTCPAGDLCSNQQF-------QKRKYVKFERFQSGKKGYGLRLLEDVREGQFLIEY--VGEVLDMQSYETRQKEYAFKGQKHFYFMTLNGNEVIDAGAKGNLGRFINHSCEPNCRTEKWMVNGEICVGIFSMQDLKKGQELTF 1140

[Close]

BLAST of WW domain-containing protein vs. TrEMBL
Match: A0A5J4NH37 (WW domain-containing protein (Fragment) OS=Paragonimus westermani OX=34504 GN=DEA37_0001707 PE=4 SV=1)

HSP 1 Score: 108.997 bits (271), Expect = 2.443e-21
Identity = 65/205 (31.71%), Postives = 105/205 (51.22%), Query Frame = 2

Query: 3098 SKECAYKDQYRVFFYHRVTKLVQWEMPVYPWE-----------GNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNN-MYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHL-----------EVTAQVESKTKAYVKTYMQSRGIIYKR 3643
              EC   + Y  ++YH  T+  +W+ PVYPW+           G DD E   Y++  AS+  V+HDEI+ MY  +   + E +  +L    A     K +S +   +  F  ++  ++ ++LR +RD+RC  G+I  DEDL YLT KL+Q ++ KE++  +                 EV+  V+S+   YVK YM+S+G  Y+R
Sbjct:   89 GTECDSSNMYAYYYYHVRTRQTRWDPPVYPWDADPMDTLTGDTGEDDPEAP-YNWGCASKFSVTHDEIEAMYSRIRQRILERQCTELLHELAG----KPDSPQGATEQSFAIELFTLVHNVLRTFRDARCKMGRIINDEDLYYLTKKLAQAVILKEVQKFHLAQAASSSSLFSAALVPEVSPIVQSRVTTYVKKYMESKGSFYRR 288

[Close]

BLAST of WW domain-containing protein vs. TrEMBL
Match: A0A0R3SGL2 (WW domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS4045 PE=4 SV=1)

HSP 1 Score: 107.842 bits (268), Expect = 6.134e-21
Identity = 63/213 (29.58%), Postives = 110/213 (51.64%), Query Frame = 2

Query: 3080 LPPFW------VSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGN----------DDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDK---------TDHLEVTAQVESKTKAYVKTYMQSRGIIYKR 3643
            LPP W       + E      Y  ++YH  T++ +W+ PVYPW+ +          DD+    Y++  A    V+H+EI+ MY       +M +++      ++  R    Q+ Q++  F  ++ ++I + LR +RDSR   G+I  DEDL+YLTNKL+Q ++ KE++ ++               EVT  ++ +  +YV+ YM+S+G  Y+R
Sbjct:  175 LPPGWQRAPNPAAAEGGEDGGYPYYYYHTKTRVTRWDPPVYPWDADPDDNLIADRPDDDPEAPYNWGCAHRYAVTHEEIEAMYAQYRK--KMLERQCMELIHDMGARPDAPQDAQEQS-FAIELFSLIHNELRRFRDSRVDLGRITNDEDLHYLTNKLAQEVVPKEIRNLHRAQQANASSLFAATPEVTPSIKDRVTSYVRRYMESKGSHYRR 384

[Close]

BLAST of WW domain-containing protein vs. TrEMBL
Match: A0A0R3UKB8 (WW domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS8019 PE=4 SV=1)

HSP 1 Score: 102.449 bits (254), Expect = 4.146e-20
Identity = 60/212 (28.30%), Postives = 107/212 (50.47%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQ----YRVFFYHRVTKLVQWEMPVYPWEGN----------DDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDH----------LEVTAQVESKTKAYVKTYMQSRGIIYKR 3643
            +PP W        D     Y  ++YH  T+  +W+ PVYPW+ +          DD+    Y++N A    V+H+EI+ MY    +   + +++       +  R    Q  Q+++ F  ++  +I + LR +RD+R + G+I +DEDL YLTNKL+Q ++ KE++ ++                EVT  +  +  +YV+ YM+++G  Y+R
Sbjct:   41 IPPGWQRAPNTASDGSDGGYAYYYYHTKTRQTRWDPPVYPWDADPEDNLIPDRPDDDPEAPYNWNCAHRFAVTHEEIEAMYAQYRS--RILERQCMELIHEMGARPDTPQGAQEQN-FAIELFTLIHNELRQFRDARVNLGRITSDEDLYYLTNKLAQEVIPKEIRSLHRAQQANASSLFAAVLPEVTPAIRERATSYVRRYMEAKGSCYRR 249

[Close]

BLAST of WW domain-containing protein vs. TrEMBL
Match: A0A564YT26 (WW domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS9299 PE=4 SV=1)

HSP 1 Score: 107.071 bits (266), Expect = 4.322e-20
Identity = 63/213 (29.58%), Postives = 110/213 (51.64%), Query Frame = 2

Query: 3080 LPPFW------VSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGN----------DDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDH---------LEVTAQVESKTKAYVKTYMQSRGIIYKR 3643
            LPP W       + E      Y  ++YH  T++ +W+ PVYPW+ +          DD+    Y++  A    V+H+EI+ MY       +M +++      ++  R    Q+ Q++  F  ++ ++I + LR +RDSR   G+I  DEDL+YLTNKL+Q ++ KE++ ++               EVT  ++ +  +YV+ YM+S+G  Y+R
Sbjct:  317 LPPGWQRAPNPAAAEGGEDGGYPYYYYHTKTRVTRWDPPVYPWDADPDDNLIADRPDDDPEAPYNWGCAHRYAVTHEEIEAMYAQYRK--KMLERQCMELIHDMGARPDAPQDAQEQS-FAIELFSLIHNELRRFRDSRVDLGRITNDEDLHYLTNKLAQEVVPKEIRNLHRAQQANASSLFAATPEVTPSIKDRVTSYVRRYMESKGSHYRR 526

[Close]

BLAST of WW domain-containing protein vs. TrEMBL
Match: A0A0R3TTK4 (WW domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS11042 PE=4 SV=2)

HSP 1 Score: 103.99 bits (258), Expect = 1.825e-19
Identity = 64/221 (28.96%), Postives = 113/221 (51.13%), Query Frame = 2

Query: 3080 LPPFW------VSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGN----------DDNELEIYDYNLASEIQVSHDEIQQMYVN---LNNMYEMKQKKLQVTKA-----NVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDK---------TDHLEVTAQVESKTKAYVKTYMQSRGIIYKR 3643
            LPP W       + E      Y  ++YH  T++ +W+ PVYPW+ +          DD+    Y++  A    V+H+EI+ +  +    ++MY   +KK+   +       +  R    Q+  +++ F  ++ ++I + LR +RDSR   G+I  DEDL+YLTNKL+Q +L KE++ ++               EVT  ++ +  +YV+ YM+S+G  Y+R
Sbjct:  186 LPPGWQRAPNPAAAEGGEDGGYPYYYYHTKTRVTRWDPPVYPWDADPDDNLIPDRPDDDPEAPYNWGCAHRYAVTHEEIETVRNSSDYFDSMYAQYRKKMLERQCMELIHEMGARPDAPQDGLEQN-FAIELFSLIHNELRRFRDSRVDLGRITNDEDLHYLTNKLAQEVLPKEIRNLHRAQQVNASSLFATTPEVTPSIKDRVASYVRRYMESKGSHYRR 405

[Close]

BLAST of WW domain-containing protein vs. Ensembl Cavefish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:NCBI gene;Acc:103039344])

HSP 1 Score: 85.1149 bits (209), Expect = 5.214e-16
Identity = 56/190 (29.47%), Postives = 88/190 (46.32%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNL--NNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH VT+  QW+ P   W+G            +  E  V H+    +       N  +   K  +  T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2715 LPPTW---KVARDPEGKIYYYHVVTRQTQWDPPT--WDG------------VGEEASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPED-LECNENVKHKTKEYIKKYMQKFGTVYR 2878

[Close]

BLAST of WW domain-containing protein vs. Ensembl Cavefish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:NCBI gene;Acc:103039344])

HSP 1 Score: 53.9138 bits (128), Expect = 1.493e-6
Identity = 37/145 (25.52%), Postives = 62/145 (42.76%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNL--NNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKL 3505
            LPP W   + A   + ++++YH VT+  QW+ P   W+G            +  E  V H+    +       N  +   K  +  T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  K+
Sbjct: 2673 LPPTW---KVARDPEGKIYYYHVVTRQTQWDPPT--WDG------------VGEEASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKV 2792

[Close]

BLAST of WW domain-containing protein vs. Ensembl Cavefish
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:NCBI gene;Acc:103039344])

HSP 1 Score: 53.5286 bits (127), Expect = 1.726e-6
Identity = 37/145 (25.52%), Postives = 62/145 (42.76%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNL--NNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKL 3505
            LPP W   + A   + ++++YH VT+  QW+ P   W+G            +  E  V H+    +       N  +   K  +  T + +AK+ KE        +F++++   I   L PYR   C  G+I   ED  +L  K+
Sbjct: 2729 LPPTW---KVARDPEGKIYYYHVVTRQTQWDPPT--WDG------------VGEEASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKE--------VFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKV 2848

[Close]

BLAST of WW domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000211.1 (pep scaffold:Pmarinus_7.0:GL478810:17844:31366:-1 gene:ENSPMAG00000000188.1 transcript:ENSPMAT00000000211.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.9669 bits (219), Expect = 3.282e-18
Identity = 57/188 (30.32%), Postives = 90/188 (47.87%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKE-SQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W     A   + ++++YH V+++ QW+ P   WEG+ D              +V  D   +M +      E   K  +  K   A    E +++N  K+ F++++  +I H L  +R   C  GKI   ED  YL  KL+  ++ KE+K+  +  D LE    V+ KTK Y+K YM   G +YK
Sbjct:  592 LPPNW---RTATDQEGKIYYYHVVSRVTQWDPPA--WEGDSD--------------EVGGDRESEMDLGTPTYDETPTKASKKPKTAEADTSSELAKKN--KETFRKELSQLIVHCLNAFRKPDCKIGKITNTEDFKYLARKLTHGVMSKEMKLCRNPED-LECNENVKHKTKEYIKKYMTKFGAVYK 757

[Close]

BLAST of WW domain-containing protein vs. Ensembl Nematostella
Match: EDO43764 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXF0])

HSP 1 Score: 70.4774 bits (171), Expect = 5.595e-14
Identity = 49/188 (26.06%), Postives = 83/188 (44.15%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKR 3643
            LPP W   + A   Q ++++YH +T+  QW+ P                     EI VS     + +     M    ++     K           + + KD F+ K+  V+ + L PY    C +G+I   ED  YL  KL+  ++ KEL+ +    + L+    V+ KTK Y+++YM+  G +Y+R
Sbjct:    5 LPPNW---KTATDPQGKIYYYHTLTRRTQWDPPT-------------------PEIVVS----PRKFTTDMEMDSGDEEPPLKKKKPKTPSTPPGAKQKIKDAFRVKLSNVVVNCLNPYHKVDCKQGRITNVEDFKYLARKLTHGVMMKELQHVKS-AESLQCNDSVKVKTKDYIRSYMKKFGPVYQR 165

[Close]

BLAST of WW domain-containing protein vs. Ensembl Nematostella
Match: EDO43763 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXE9])

HSP 1 Score: 50.8322 bits (120), Expect = 2.086e-6
Identity = 47/193 (24.35%), Postives = 75/193 (38.86%), Query Frame = 2

Query: 1835 THEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHS--IPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKHIKIDVSRDVHSYMHYLRYTRSLE---------------QANVDIEKWIACGRTRLGIFAVKDLQPGEEL 2362
              +M C C  P PD  N     C  G++C+   L IEC N  CP   LC N +F             +   +VF +    W ++T + +++N+ + E  G            E      F S+  + D  +  H Y   LR    ++               + N   +KW   G  R+G F ++ ++ GEEL
Sbjct:   24 VRKMTCEC-YPEPD--NPDFVGC--GEDCLNRLLMIEC-NHRCPCGDLCTNRRF---------QEGCKIKVEVFKTEKKGWGVKTLEDLEQNQFVIEYCG------------EVMNYRDFQSRAQRYDRQKRRHYYFMTLRADEIIDATLKGSISRFINHSCEPNCVTQKWTVNGLLRIGFFTLRTIKAGEEL 189

[Close]

BLAST of WW domain-containing protein vs. Ensembl Nematostella
Match: EDO43156 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZJ4])

HSP 1 Score: 51.6026 bits (122), Expect = 2.263e-6
Identity = 42/174 (24.14%), Postives = 71/174 (40.80%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAG-IGEMSPGKGHEPEASTTSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLL 2368
            C CT   PD+      +C    NC+   L+ EC    CP    C N +F     +  +  + E F    HS  W +R+K+ I+K   + E  G + + +  +    +    + +    I  D   D     +  R+       N + +KW   G  R+G+F  +D++  EEL  
Sbjct:  333 CECT---PDQ------ACGQDANCLNLMLQFECVASRCPAGDKCQNQRF-----QKRQYVDCEPF--RAHSRGWGLRSKQAIKKGTFVIEYVGELIDDATCRERVKKGDDDTNYYMLTIDKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQEELTF 490

[Close]

BLAST of WW domain-containing protein vs. Ensembl Medaka
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:NCBI gene;Acc:101163764])

HSP 1 Score: 88.1965 bits (217), Expect = 6.029e-17
Identity = 59/191 (30.89%), Postives = 94/191 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQV---SHDEIQQMYVNLNNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH VT+  QW+ P   WEG+ D+       +  SE+ +   ++DE         N  +   K  +  T + +AK+ KE+        F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2416 LPPNW---KVARDPEGKIYYYHIVTRQTQWDPPT--WEGSSDS----TSVDHESEMDLGTPTYDE---------NPSKFSTKTAEADTSSELAKKSKET--------FRKEMSQFIVQCLNPYRKPDCKSGRISNTEDFKHLARKLTHGVMNKELKACKNPED-LECNENVKHKTKEYIKKYMQRFGTVYR 2579

[Close]

BLAST of WW domain-containing protein vs. Ensembl Medaka
Match: setd2 (SET domain containing 2, histone lysine methyltransferase [Source:NCBI gene;Acc:101163764])

HSP 1 Score: 87.8113 bits (216), Expect = 6.878e-17
Identity = 59/191 (30.89%), Postives = 94/191 (49.21%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQV---SHDEIQQMYVNLNNMYEMKQKKLQV-TKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYK 3640
            LPP W   + A   + ++++YH VT+  QW+ P   WEG+ D+       +  SE+ +   ++DE         N  +   K  +  T + +AK+ KE+        F++++   I   L PYR   C  G+I   ED  +L  KL+  ++ KELK   +  D LE    V+ KTK Y+K YMQ  G +Y+
Sbjct: 2368 LPPNW---KVARDPEGKIYYYHIVTRQTQWDPPT--WEGSSDS----TSVDHESEMDLGTPTYDE---------NPSKFSTKTAEADTSSELAKKSKET--------FRKEMSQFIVQCLNPYRKPDCKSGRISNTEDFKHLARKLTHGVMNKELKACKNPED-LECNENVKHKTKEYIKKYMQRFGTVYR 2531

[Close]

BLAST of WW domain-containing protein vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 53.5286 bits (127), Expect = 1.637e-6
Identity = 46/163 (28.22%), Postives = 69/163 (42.33%), Query Frame = 2

Query: 1901 CSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGI----GEMSPGKGHEPEASTTSVFISKHIKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C S   CI   L  EC+ Q CP    C N  F    TK   S+ +E F  +  S  W +R    I+K + + E  G      E      H  E    + ++   + +D  R  D     +  R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 1644 CGSDSECINRMLLYECNPQVCPAGEKCLNQAF----TKRQYSQ-VEIFRTL--SRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYM---LTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFN 1796

[Close]

BLAST of WW domain-containing protein vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 53.1434 bits (126), Expect = 2.518e-6
Identity = 46/163 (28.22%), Postives = 69/163 (42.33%), Query Frame = 2

Query: 1901 CSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGI----GEMSPGKGHEPEASTTSVFISKHIKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C S   CI   L  EC+ Q CP    C N  F    TK   S+ +E F  +  S  W +R    I+K + + E  G      E      H  E    + ++   + +D  R  D     +  R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 2050 CGSDSECINRMLLYECNPQVCPAGEKCLNQAF----TKRQYSQ-VEIFRTL--SRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYM---LTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFN 2202

[Close]

BLAST of WW domain-containing protein vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079])

HSP 1 Score: 53.1434 bits (126), Expect = 2.518e-6
Identity = 46/163 (28.22%), Postives = 69/163 (42.33%), Query Frame = 2

Query: 1901 CSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGI----GEMSPGKGHEPEASTTSVFISKHIKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            C S   CI   L  EC+ Q CP    C N  F    TK   S+ +E F  +  S  W +R    I+K + + E  G      E      H  E    + ++   + +D  R  D     +  R+     Q N + +KW   G TR+G+FA+ D++ G EL  +
Sbjct: 2050 CGSDSECINRMLLYECNPQVCPAGEKCLNQAF----TKRQYSQ-VEIFRTL--SRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYM---LTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFN 2202

[Close]

BLAST of WW domain-containing protein vs. Planmine SMEST
Match: SMESG000049121.1 (SMESG000049121.1)

HSP 1 Score: 2034.22 bits (5269), Expect = 0.000e+0
Identity = 1110/1206 (92.04%), Postives = 1120/1206 (92.87%), Query Frame = 2

Query:   77 MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVIKKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATKLKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIEMINNHEKERLDKIKNEAQDNPXXXXXXXXXXXXXXXHSANYNNDNRSKYYTKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFMAPILNYGRGDQKHEHQSHRTLGNHYPIHRNDLRHRERSKGKGIDGHRWKEQQSTVAVKPHRTKQWAAEAGKSGKKVVPSTREQSALXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVPYELECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLNEEKLLNIPLPISDKAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPEMPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAKSRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLHLPDDNAIDTSYTXXXXXXXXXXXXXXXXXXXXXXTDKADVLACIRY----XXXXXXXXXXXXXXXXXXXXXXQSCRPNQNHPPVLLNWVVELGMPAVLCCICDDELAASCRRR-HKXXXXXXXXXXXXXXXXXXXXLSFHKLIDLLLLLVPYSHRKQLQTLGFDLPGFVSRTYSQLAAANPRIPLTAHFVEKLHNLCQKLSSIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDMLHCRLPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVHCSIPDQRNG 3679
            MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVIKKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATKLKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIEMINNH KERLDK KNEAQDNPVVMKSQVVVKK+NMKHSANYNNDNRSKYYTKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFM PILNYGRGDQKHEHQSHRTLGNHYPIHRNDLRHRERSK KGIDGHRWKEQ+STVAVKPHRTKQWAAEAGKSGKKVVPSTREQSALSPSTSRSSSSSSSSS S S SS  SSGSS S  S    RNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVP ELECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLN+EKLLNIPLPISDKAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPEMPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAKSRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECD QHCPTE LCCNTQFFDLDTKSNKSRNIEFFFDV+HSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGH PEAS TSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLHLPDDNAIDTSYT  P           LSPSQL PTDKADVLACIRY          A  + L +     LLLQSCRPNQ++PPVLLNWVVELGMPAVLCCICDDELAASCRRR HK     GEGEGEGE    AAELSFHKLIDLLLLLVPYSH KQLQT GFDLPGFVSRTYSQLAAANPRIPLTAHFVEKLHNLCQKLSSI                  P APPAPPLSAAAADMLHCRLPPFWVSKECAYK QYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRC+EGKIETDEDLNYLTNKLSQTILYKELKI+NDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVHCSIPDQRNG
Sbjct:    1 MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVIKKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATKLKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIEMINNHVKERLDKRKNEAQDNPVVMKSQVVVKKTNMKHSANYNNDNRSKYYTKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFMEPILNYGRGDQKHEHQSHRTLGNHYPIHRNDLRHRERSKVKGIDGHRWKEQESTVAVKPHRTKQWAAEAGKSGKKVVPSTREQSALSPSTSRSSSSSSSSSSSGSSSSGSSSGSSASINSS---RNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVPDELECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLNKEKLLNIPLPISDKAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPEMPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAKSRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDIQHCPTECLCCNTQFFDLDTKSNKSRNIEFFFDVYHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHGPEASRTSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLHLPDDNAIDTSYT-LPPSLSPLSPLSPLSPSQLLPTDKADVLACIRYLIHEPPAAAAAVPLLLPVLDTLLLLLQSCRPNQHNPPVLLNWVVELGMPAVLCCICDDELAASCRRRGHK--GAAGEGEGEGEGELPAAELSFHKLIDLLLLLVPYSHSKQLQTFGFDLPGFVSRTYSQLAAANPRIPLTAHFVEKLHNLCQKLSSI----------GAGESPGAPPAPPAPPLSAAAADMLHCRLPPFWVSKECAYKGQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCTEGKIETDEDLNYLTNKLSQTILYKELKILNDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVHCSIPDQRNG 1190

[Close]

BLAST of WW domain-containing protein vs. Planmine SMEST
Match: SMESG000049121.1 (SMESG000049121.1)

HSP 1 Score: 1962.19 bits (5082), Expect = 0.000e+0
Identity = 1076/1172 (91.81%), Postives = 1086/1172 (92.66%), Query Frame = 2

Query:   77 MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVIKKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATKLKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIEMINNHEKERLDKIKNEAQDNPXXXXXXXXXXXXXXXHSANYNNDNRSKYYTKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFMAPILNYGRGDQKHEHQSHRTLGNHYPIHRNDLRHRERSKGKGIDGHRWKEQQSTVAVKPHRTKQWAAEAGKSGKKVVPSTREQSALXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVPYELECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLNEEKLLNIPLPISDKAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPEMPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAKSRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEASTTSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLHLPDDNAIDTSYTXXXXXXXXXXXXXXXXXXXXXXTDKADVLACIRY----XXXXXXXXXXXXXXXXXXXXXXQSCRPNQNHPPVLLNWVVELGMPAVLCCICDDELAASCRRR-HKXXXXXXXXXXXXXXXXXXXXLSFHKLIDLLLLLVPYSHRKQLQTLGFDLPGFVSRTYSQLAAANPRIPLTAHFVEKLHNLCQKLSSIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDMLHCRLPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQ 3577
            MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVIKKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATKLKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIEMINNH KERLDK KNEAQDNPVVMKSQVVVKK+NMKHSANYNNDNRSKYYTKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFM PILNYGRGDQKHEHQSHRTLGNHYPIHRNDLRHRERSK KGIDGHRWKEQ+STVAVKPHRTKQWAAEAGKSGKKVVPSTREQSALSPSTSRSSSSSSSSS S S SS  SSGSS S  S    RNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVP ELECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLN+EKLLNIPLPISDKAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPEMPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAKSRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECD QHCPTE LCCNTQFFDLDTKSNKSRNIEFFFDV+HSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGH PEAS TSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLHLPDDNAIDTSYT  P           LSPSQL PTDKADVLACIRY          A  + L +     LLLQSCRPNQ++PPVLLNWVVELGMPAVLCCICDDELAASCRRR HK     GEGEGEGE    AAELSFHKLIDLLLLLVPYSH KQLQT GFDLPGFVSRTYSQLAAANPRIPLTAHFVEKLHNLCQKLSSI                  P APPAPPLSAAAADMLHCRLPPFWVSKECAYK QYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRC+EGKIETDEDLNYLTNKLSQTILYKELKI+NDKTDHLEVTAQ
Sbjct:    1 MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVIKKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATKLKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIEMINNHVKERLDKRKNEAQDNPVVMKSQVVVKKTNMKHSANYNNDNRSKYYTKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFMEPILNYGRGDQKHEHQSHRTLGNHYPIHRNDLRHRERSKVKGIDGHRWKEQESTVAVKPHRTKQWAAEAGKSGKKVVPSTREQSALSPSTSRSSSSSSSSSSSGSSSSGSSSGSSASINSS---RNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVPDELECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLNKEKLLNIPLPISDKAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPEMPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAKSRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDIQHCPTECLCCNTQFFDLDTKSNKSRNIEFFFDVYHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHGPEASRTSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLHLPDDNAIDTSYT-LPPSLSPLSPLSPLSPSQLLPTDKADVLACIRYLIHEPPAAAAAVPLLLPVLDTLLLLLQSCRPNQHNPPVLLNWVVELGMPAVLCCICDDELAASCRRRGHK--GAAGEGEGEGEGELPAAELSFHKLIDLLLLLVPYSHSKQLQTFGFDLPGFVSRTYSQLAAANPRIPLTAHFVEKLHNLCQKLSSI----------GAGESPGAPPAPPAPPLSAAAADMLHCRLPPFWVSKECAYKGQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCTEGKIETDEDLNYLTNKLSQTILYKELKILNDKTDHLEVTAQ 1156

[Close]

BLAST of WW domain-containing protein vs. Planmine SMEST
Match: SMESG000076590.1 (SMESG000076590.1)

HSP 1 Score: 112.849 bits (281), Expect = 1.049e-24
Identity = 58/190 (30.53%), Postives = 115/190 (60.53%), Query Frame = 2

Query: 3080 LPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYDYNLASEIQVSHDEIQQMYVNLNNMYEMKQ----KKLQVTKANVAKRKKESQENQKKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYKELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIY 3637
            LPP W S++    +   +++Y+ VTK+ QWE+PVYPW+  + + +  Y++  AS+ Q+S  ++Q MY      Y++++    +K ++ ++ + ++   S  ++ K  F +++   +  +++PY  S C  G+I+  +DL +L  K + TI+ KE+K++ +  D LE+ A V+SK K+Y++ YM ++G  Y
Sbjct: 2172 LPPNWHSRQA---ENGNLYYYNTVTKITQWEIPVYPWDAGEADPM-AYNFGNASDYQISRKDVQIMYEEYRKSYKLQRLEERRKTRIERS-IQRKLNLSPGDKNKIEFSKQVFRAVKTVVKPYNTSSCKLGRIQHKQDLKFLCEKFADTIIGKEVKLVANLED-LEMNANVKSKIKSYIEKYMANQGRCY 2355

HSP 2 Score: 64.3142 bits (155), Expect = 6.546e-10
Identity = 53/178 (29.78%), Postives = 74/178 (41.57%), Query Frame = 2

Query: 1850 CRCTMPNPDEWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSI---PWKIRTKKFIQKNKLIFEVAG-----------IGEMSPGKGHEPEASTTSVFISKHIKIDVSRDV-HSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVK 2338
            C C  PNPDE   G  +C  G+NC   ++++EC N+ CP   LC N +F            I   F+ F+      W IRT   I     I E  G           I + S    H   +   S++I   +K + SR V HS              N  IE+W+  G+TR+G F+ K
Sbjct: 1567 CNCVPPNPDEIKLGKTAC--GENCFNRRIKVEC-NRKCPVYELCTNRRF---------QEQIYAPFEPFYCTNGKGWGIRTTNRIYPGTFIIEYVGELIDFHEFLSRIRQKSTYNHHFIMSIQKSMYIDAGMKGNWSRFVNHSC-----------DPNTVIERWVVNGKTRIGFFSKK 1721

[Close]

BLAST of WW domain-containing protein vs. Planmine SMEST
Match: SMESG000015015.1 (SMESG000015015.1)

HSP 1 Score: 52.7582 bits (125), Expect = 1.832e-6
Identity = 41/160 (25.62%), Postives = 68/160 (42.50%), Query Frame = 2

Query: 1901 CSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKSRNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAG-IGEMSPGKGHEPEASTTSVFISKHIKIDVSR--DVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGIFAVKDLQPGEELLLH 2371
            CS G  C     + ECD Q C     C N  F     K    +   F+ +      W ++  +FI+  + + E  G I  M   +     A+  ++     +++D  R  D   + +  R+  +    N+  EKWI     R+G+FA++D+Q GEEL   
Sbjct:  603 CSIGSGCFNVASKCECDPQICNLGDKCKNQNF----VKRIYPKQYTFWAN---DRGWGLKADEFIKTKQFVNEYIGEIITMEESEKRILWANENNISDFYFMELDNGRLIDARQFSNLSRFINNSCDPNLVAEKWIVNREHRIGLFALRDIQKGEELTFQ 755

The following BLAST results are available for this feature:

BLAST of WW domain-containing protein vs. Ensembl Human
BLAST of WW domain-containing protein vs. Ensembl Celegans
BLAST of WW domain-containing protein vs. Ensembl Fly
BLAST of WW domain-containing protein vs. Ensembl Zebrafish
BLAST of WW domain-containing protein vs. Ensembl Xenopus
BLAST of WW domain-containing protein vs. Ensembl Mouse
BLAST of WW domain-containing protein vs. UniProt/SwissProt
BLAST of WW domain-containing protein vs. TrEMBL
BLAST of WW domain-containing protein vs. Ensembl Cavefish
BLAST of WW domain-containing protein vs. Ensembl Sea Lamprey
BLAST of WW domain-containing protein vs. Ensembl Yeast
BLAST of WW domain-containing protein vs. Ensembl Nematostella
BLAST of WW domain-containing protein vs. Ensembl Medaka
BLAST of WW domain-containing protein vs. Planmine SMEST

BLAST of WW domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
SETD2	4.116e-17	31.75	SET domain containing 2, histone lysine methyltran...	[more]
NSD1	1.229e-6	26.23	nuclear receptor binding SET domain protein 1 [Sou...	[more]
NSD1	1.440e-6	26.23	nuclear receptor binding SET domain protein 1 [Sou...	[more]
NSD1	1.440e-6	26.23	nuclear receptor binding SET domain protein 1 [Sou...	[more]

BLAST of WW domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of WW domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Set2	1.134e-10	31.36	gene:FBgn0030486 transcript:FBtr0301559	[more]
Set2	1.176e-10	31.36	gene:FBgn0030486 transcript:FBtr0073779	[more]

BLAST of WW domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
setd2	9.129e-16	29.47	SET domain containing 2, histone lysine methyltran...	[more]
setd2	9.789e-16	29.47	SET domain containing 2, histone lysine methyltran...	[more]
setd2	1.004e-15	29.47	SET domain containing 2, histone lysine methyltran...	[more]
setd2	3.254e-15	29.41	SET domain containing 2, histone lysine methyltran...	[more]

BLAST of WW domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
macroh2a1	7.687e-15	30.00	macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855...	[more]
macroh2a1	8.475e-15	30.00	macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855...	[more]
macroh2a1	9.686e-15	28.57	macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855...	[more]
macroh2a1	9.786e-15	28.57	macroH2A.1 histone [Source:Xenbase;Acc:XB-GENE-855...	[more]

BLAST of WW domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Setd2	2.942e-17	31.75	SET domain containing 2 [Source:MGI Symbol;Acc:MGI...	[more]
Setd2	3.957e-17	31.75	SET domain containing 2 [Source:MGI Symbol;Acc:MGI...	[more]
Nsd1	1.129e-6	26.23	nuclear receptor-binding SET-domain protein 1 [Sou...	[more]
Nsd1	1.264e-6	26.23	nuclear receptor-binding SET-domain protein 1 [Sou...	[more]

BLAST of WW domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9BYW2\|SETD2_HUMAN	1.977e-16	31.75	Histone-lysine N-methyltransferase SETD2 OS=Homo s...	[more]
sp\|E9Q5F9\|SETD2_MOUSE	2.058e-16	31.75	Histone-lysine N-methyltransferase SETD2 OS=Mus mu...	[more]
sp\|Q9VYD1\|C1716_DROME	2.194e-9	31.36	Probable histone-lysine N-methyltransferase CG1716...	[more]
sp\|Q96L73\|NSD1_HUMAN	5.900e-6	26.23	Histone-lysine N-methyltransferase, H3 lysine-36 s...	[more]
sp\|Q2LAE1\|ASHH2_ARATH	6.887e-6	23.00	Histone-lysine N-methyltransferase ASHH2 OS=Arabid...	[more]

BLAST of WW domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A5J4NH37	2.443e-21	31.71	WW domain-containing protein (Fragment) OS=Paragon...	[more]
A0A0R3SGL2	6.134e-21	29.58	WW domain-containing protein OS=Hymenolepis diminu...	[more]
A0A0R3UKB8	4.146e-20	28.30	WW domain-containing protein OS=Mesocestoides cort...	[more]
A0A564YT26	4.322e-20	29.58	WW domain-containing protein OS=Hymenolepis diminu...	[more]
A0A0R3TTK4	1.825e-19	28.96	WW domain-containing protein OS=Rodentolepis nana ...	[more]

BLAST of WW domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
setd2	5.214e-16	29.47	SET domain containing 2, histone lysine methyltran...	[more]
setd2	1.493e-6	25.52	SET domain containing 2, histone lysine methyltran...	[more]
setd2	1.726e-6	25.52	SET domain containing 2, histone lysine methyltran...	[more]

BLAST of WW domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000000211.1	3.282e-18	30.32	pep scaffold:Pmarinus_7.0:GL478810:17844:31366:-1 ...	[more]

BLAST of WW domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of WW domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO43764	5.595e-14	26.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43763	2.086e-6	24.35	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43156	2.263e-6	24.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of WW domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
setd2	6.029e-17	30.89	SET domain containing 2, histone lysine methyltran...	[more]
setd2	6.878e-17	30.89	SET domain containing 2, histone lysine methyltran...	[more]
nsd1b	1.637e-6	28.22	histone-lysine N-methyltransferase, H3 lysine-36 a...	[more]
nsd1b	2.518e-6	28.22	histone-lysine N-methyltransferase, H3 lysine-36 a...	[more]
nsd1b	2.518e-6	28.22	histone-lysine N-methyltransferase, H3 lysine-36 a...	[more]

BLAST of WW domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000049121.1	0.000e+0	92.04	SMESG000049121.1	[more]
SMESG000049121.1	0.000e+0	91.81	SMESG000049121.1	[more]
SMESG000076590.1	1.049e-24	30.53	SMESG000076590.1	[more]
SMESG000015015.1	1.832e-6	25.63	SMESG000015015.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30028310 ID=SMED30028310|Name=WW domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3774bp
ATCGAAATGTATATAAATCTTATATGATAATCAATTTATTTTTTCCCTAA
TTTTGTTATAAAAATCACATAGATTTATGAATATAAATGATATTCCTTTA
CCTCCAACACCTAAAAATAAGCTTTATAACGCTTCTAAAGTCTTAGAAAA
TAAAGATAATCATGCATCATCAAGTCGCATTTTCCCAGTGAAACGCCATG
TGAATAAATTACCAGTTGGTGTCATAAAGAAGAATGATGACGGTAAAATT
GGGGAATTAACGCTTCATAGAAAAGAATTATTTTTGCCTACAATGAATGA
TAAAATTCAACTAGCTATGTCTAATCTAAATCCAACTCAAAGTAAAAAAT
TAGAAATGCTATTAAATGCAACAAAATTAAAGCCTGTTGAATTACATATT
AACGACAATATTGTAAATCATAACCAAATGAATAAAGTAAAAAATAAGTT
TGTTGATGAAAAATTTGAAAACAGAAAACGTAGACAAGAACATAATTTAA
AAGGTTCCAAAAAACCTAAAATTGAAATGATAAATAATCATGAAAAGGAA
AGACTAGACAAAATAAAGAATGAAGCTCAAGATAATCCTGTTGTTATGAA
ATCACAGGTTGTTGTAAAGAAAAGCAATATGAAACATTCCGCAAATTACA
ACAATGATAATAGAAGCAAATATTACACGAAATGGAATCTATCACCTCAT
TATCATGACCGGAATCGTAATAATGTGCGTGATTATCACCGAAATAGCAG
CAACCATAATAACAATGATTACAAACAAAACAAATCATCATTTATGGCAC
CAATACTGAATTATGGCAGAGGCGACCAGAAACACGAGCATCAATCGCAC
AGGACGCTGGGTAATCACTATCCAATCCACCGGAATGACTTGCGTCATAG
AGAAAGAAGCAAGGGGAAAGGGATTGATGGCCACCGATGGAAAGAGCAAC
AATCAACCGTAGCGGTAAAGCCACATAGAACAAAGCAGTGGGCGGCGGAA
GCAGGGAAAAGCGGGAAGAAAGTTGTGCCATCGACACGAGAGCAATCGGC
GCTGTCACCAAGCACATCGCGGAGCTCATCATCATCATCATCATCATCAG
GATCATCATCAGGATCATCATCCGGCTCATCCGGCTCATCCGGCTCATCA
GCATCCATTAACAGCAGCAGGAACACTAATGAACCAATGGAGCTGCCGGC
GGTCAGTCCCAACAGCCCAGATGAGGATAACCCACTGATGGACAGCAGCA
ATGACGGGCAGGTACCCTATGAGTTAGAGTGCACAGCACTGGCCAATAAT
TGCCTCAAGGAGTTATCAGCCACTCTGGTCAAGATGAATCAGGCGTACAA
ATCCGTTTATTCCAAAATTCCAAACATCAAACTGAATGAAGAGAAATTAT
TGAATATCCCGTTGCCAATCAGTGATAAAGCGCCTTGTACCGATTCCCCC
ACATTGAATGCGCGATATCCCCAGAGCGTGTCCACTGACAACCGCATCGA
TAAACCACCATTACAACTGACCAATGGGGCTTGCGATGTCACCACAGACG
GTGTACCGAAGGAGGAGCAGCCTGAAATGCCGCTCAAGCCAAGAATTGTC
AGTGATAACATGGACAATCTCTCACATATCAGCCGCAGCTCCTGCGGCTC
CAAAAATGGTAAATCTCCATTTTACTCTCACAACCTGTCCAACGCCAGCA
AGGAATCAGAATGCTTGGACGCAAAATCACGTCCACTGGTCCCGAAAATA
TCGAATTTCTCAATCGATTATTGCAATATAGATTCAGTGACCATCAATGA
AATAGTGTCCCAGCATAACTCACCTCGATATTTCACCCATGAGATGCGCT
GCCGCTGTACAATGCCCAATCCTGATGAGTGGAACGAAGGAGTTAGATCA
TGCAGTAGTGGTCAAAACTGCATTCTCGCCCAGTTGCGCATCGAATGTGA
TAATCAACATTGCCCAACCGAAAGTTTATGCTGCAATACTCAATTCTTCG
ATCTCGATACAAAATCAAATAAATCGCGCAATATCGAGTTCTTTTTCGAT
GTCTTCCACTCGATTCCGTGGAAAATTCGCACAAAGAAATTCATTCAAAA
GAACAAGCTGATATTCGAGGTTGCGGGAATCGGGGAAATGTCCCCTGGAA
AAGGACACGAACCTGAAGCCTCCACGACATCAGTATTCATATCGAAACAC
ATCAAGATCGATGTCAGTAGGGATGTGCACAGCTACATGCATTATTTGCG
CTACACACGGTCCCTGGAGCAGGCGAATGTCGACATTGAGAAATGGATCG
CCTGCGGTAGGACGCGGCTGGGGATATTTGCCGTGAAGGATTTGCAGCCG
GGCGAGGAATTGCTGCTCCACCTCCCGGATGACAATGCGATTGACACGAG
TTACACGCTGCCGCCCTCCCTGTCCCCACTGTCCCCCCTGTCCCCCTCCC
TGTCCCCCTCCCAGTTGCCCCCCACCGACAAAGCGGATGTATTGGCTTGC
ATTCGCTACCTGGTCCATGAGCCGCCAGCAGCAGCAGTTCCCCTGCTGCT
GCCCGTGCTTGATACGCTGCTGCTGCAGTCCTGCCGTCCAAACCAGAACC
ACCCGCCCGTTCTCCTCAATTGGGTAGTGGAACTGGGAATGCCAGCAGTG
CTGTGCTGCATCTGTGATGATGAATTGGCTGCCTCCTGCCGCCGCCGCCA
TAAAGGGGCAGCAGGAGAGGGAGAGGGAGAGGGAGAGGGGGAATTACCCG
CTGCCGCTGCCGAGCTCTCATTCCACAAGCTGATCGACCTGCTGCTGTTA
CTCGTGCCTTACTCACATAGGAAACAGCTACAGACACTCGGTTTCGACCT
GCCCGGCTTTGTCAGCCGTACCTACAGCCAATTGGCAGCCGCCAATCCGC
GGATTCCGCTCACCGCTCATTTCGTTGAAAAACTCCACAATCTCTGTCAG
AAACTCTCTTCCATTGGTGCAGGGGAATCTCCTGGTGCTCCTCCTCCTGG
TGCTCCTCCCGGTGCTCCTCCCGGTGCTCCTCCTGCTCCTCCATTGTCCG
CCGCCGCAGCCGACATGCTACACTGCCGGCTGCCTCCGTTCTGGGTTTCA
AAGGAGTGCGCATACAAGGATCAATATCGGGTATTCTTCTATCACCGCGT
GACGAAATTGGTGCAGTGGGAAATGCCGGTCTATCCCTGGGAGGGTAACG
ATGACAATGAGCTTGAGATCTATGACTACAACTTGGCTAGTGAGATACAG
GTTTCCCATGACGAGATTCAGCAGATGTACGTCAACCTGAACAACATGTA
CGAAATGAAACAGAAAAAGTTGCAAGTGACCAAGGCAAATGTCGCCAAGC
GCAAGAAAGAAAGCCAAGAGAATCAAAAGAAAGATCTATTCAAGAGAAAG
ATCATGGCAGTCATTGCTCACTTGCTCAGGCCGTATCGAGATTCTCGGTG
TTCCGAAGGCAAAATAGAGACCGACGAGGATCTCAATTATTTGACGAACA
AGCTGTCCCAAACTATCCTATACAAAGAGCTCAAGATCATCAACGACAAA
ACCGATCACCTTGAAGTTACAGCACAGGTGGAATCCAAAACAAAAGCCTA
TGTGAAAACATATATGCAATCCAGGGGAATTATCTATAAGCGGCCCGTTC
ATTGCTCAATACCAGATCAGAGAAATGGACTGCTGCCTCCACTGCTGCCT
CCATTGCCACAAGGGTGACAATACGTGATTATCGATTTTGTATATTGTAT
ATTATGTCGTTTCTTTTATCATCA

protein sequence of SMED30028310-orf-1

>SMED30028310-orf-1 ID=SMED30028310-orf-1|Name=SMED30028310-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1214bp
MNINDIPLPPTPKNKLYNASKVLENKDNHASSSRIFPVKRHVNKLPVGVI
KKNDDGKIGELTLHRKELFLPTMNDKIQLAMSNLNPTQSKKLEMLLNATK
LKPVELHINDNIVNHNQMNKVKNKFVDEKFENRKRRQEHNLKGSKKPKIE
MINNHEKERLDKIKNEAQDNPVVMKSQVVVKKSNMKHSANYNNDNRSKYY
TKWNLSPHYHDRNRNNVRDYHRNSSNHNNNDYKQNKSSFMAPILNYGRGD
QKHEHQSHRTLGNHYPIHRNDLRHRERSKGKGIDGHRWKEQQSTVAVKPH
RTKQWAAEAGKSGKKVVPSTREQSALSPSTSRSSSSSSSSSGSSSGSSSG
SSGSSGSSASINSSRNTNEPMELPAVSPNSPDEDNPLMDSSNDGQVPYEL
ECTALANNCLKELSATLVKMNQAYKSVYSKIPNIKLNEEKLLNIPLPISD
KAPCTDSPTLNARYPQSVSTDNRIDKPPLQLTNGACDVTTDGVPKEEQPE
MPLKPRIVSDNMDNLSHISRSSCGSKNGKSPFYSHNLSNASKESECLDAK
SRPLVPKISNFSIDYCNIDSVTINEIVSQHNSPRYFTHEMRCRCTMPNPD
EWNEGVRSCSSGQNCILAQLRIECDNQHCPTESLCCNTQFFDLDTKSNKS
RNIEFFFDVFHSIPWKIRTKKFIQKNKLIFEVAGIGEMSPGKGHEPEAST
TSVFISKHIKIDVSRDVHSYMHYLRYTRSLEQANVDIEKWIACGRTRLGI
FAVKDLQPGEELLLHLPDDNAIDTSYTLPPSLSPLSPLSPSLSPSQLPPT
DKADVLACIRYLVHEPPAAAVPLLLPVLDTLLLQSCRPNQNHPPVLLNWV
VELGMPAVLCCICDDELAASCRRRHKGAAGEGEGEGEGELPAAAAELSFH
KLIDLLLLLVPYSHRKQLQTLGFDLPGFVSRTYSQLAAANPRIPLTAHFV
EKLHNLCQKLSSIGAGESPGAPPPGAPPGAPPGAPPAPPLSAAAADMLHC
RLPPFWVSKECAYKDQYRVFFYHRVTKLVQWEMPVYPWEGNDDNELEIYD
YNLASEIQVSHDEIQQMYVNLNNMYEMKQKKLQVTKANVAKRKKESQENQ
KKDLFKRKIMAVIAHLLRPYRDSRCSEGKIETDEDLNYLTNKLSQTILYK
ELKIINDKTDHLEVTAQVESKTKAYVKTYMQSRGIIYKRPVHCSIPDQRN
GLLPPLLPPLPQG*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR038190	SRI_sf
IPR042294	SETD2
IPR013257	SRI
IPR001202	WW_dom
IPR006560	AWS_dom

Vocabulary: **molecular function**
Term	Definition
GO:0046975	histone methyltransferase activity (H3-K36 specific)
GO:0018024	histone-lysine N-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0097198	histone H3-K36 trimethylation
GO:0006355	regulation of transcription, DNA-templated
GO:0034968	histone lysine methylation
GO:0032259	methylation

Vocabulary: **cellular component**
Term	Definition
GO:0005694	chromosome
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 1076..1096
None	No IPR available	GENE3D	G3DSA:2.170.270.10		coord: 562..768 e-value: 3.4E-14 score: 54.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 269..297
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 317..371
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 269..382
None	No IPR available	SUPERFAMILY	SSF82199	SET domain	coord: 556..761
IPR013257	Set2 Rpb1 interacting domain	PFAM	PF08236	SRI	coord: 1088..1177 e-value: 3.4E-13 score: 49.6
IPR038190	Set2 Rpb1 interacting domain superfamily	GENE3D	G3DSA:1.10.1740.100		coord: 1073..1183 e-value: 2.6E-24 score: 87.2
IPR042294	Histone-lysine N-methyltransferase SETD2	PANTHER	PTHR46711	FAMILY NOT NAMED	coord: 974..1178
IPR001202	WW domain	PROSITE	PS50020	WW_DOMAIN_2	coord: 989..1025 score: 9.044

Main menu

WW domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

blazegraph-runner