Translation initiation factor eIF-2B subunit alpha

Overview
NameTranslation initiation factor eIF-2B subunit alpha
Smed IDSMED30028259
Length (bp)967
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Translation initiation factor eIF-2B subunit alpha (SMED30028259) t-SNE clustered cells

Violin plots show distribution of expression levels for Translation initiation factor eIF-2B subunit alpha (SMED30028259) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Translation initiation factor eIF-2B subunit alpha (SMED30028259) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Translation initiation factor eIF-2B subunit alpha (SMED30028259) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30028259

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30028259SMESG000039439.1 SmedASXL_004865SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Human
Match: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha [Source:HGNC Symbol;Acc:HGNC:3257])

HSP 1 Score: 176.407 bits (446), Expect = 1.807e-52
Identity = 105/302 (34.77%), Postives = 174/302 (57.62%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKA---SVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  +++L H  S+ V   L   V   ++K+ ++YV    P  + K   + L +  V +  +   ++ + +E+ D V  GAE VV +GGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+QQD+P +F+YKA    V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLASLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVA--AKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Human
Match: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha [Source:HGNC Symbol;Acc:HGNC:3257])

HSP 1 Score: 66.2402 bits (160), Expect = 4.249e-12
Identity = 43/149 (28.86%), Postives = 82/149 (55.03%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYV 511
            EYF      D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  +++L H  S+ V   L   V   ++K+ ++YV
Sbjct:    8 EYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLASLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVA--AKKRFSVYV 152
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Human
Match: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha [Source:HGNC Symbol;Acc:HGNC:3257])

HSP 1 Score: 62.7734 bits (151), Expect = 4.500e-11
Identity = 40/141 (28.37%), Postives = 79/141 (56.03%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYV 511
             D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  +++L H  S+ V   L   V   ++K+ ++YV
Sbjct:    3 EDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLASLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVA--AKKRFSVYV 139
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Human
Match: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha [Source:HGNC Symbol;Acc:HGNC:3257])

HSP 1 Score: 54.6842 bits (130), Expect = 1.361e-8
Identity = 38/129 (29.46%), Postives = 70/129 (54.26%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTV 451
            EYF      D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K     L HG S++ 
Sbjct:   24 EYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLASLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK--DGALHHGESRSC 148
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Human
Match: EIF2B4 (eukaryotic translation initiation factor 2B subunit delta [Source:HGNC Symbol;Acc:HGNC:3260])

HSP 1 Score: 55.0694 bits (131), Expect = 9.060e-8
Identity = 53/221 (23.98%), Postives = 103/221 (46.61%), Query Frame = 2 
Query:  311 DFKSNLIKKADLFIA-KITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNL------SNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRF-----TRLFPLSQQDIPTEFRYK-----ASVRAQNKDLTAVMPDLEY--VRPEYISMIITDIGCIP 916
            + KS L    D ++  KI  +   I++ +   + +   +LV+G S  V   +        R+   + V   P    +  +R+L      ++Y+ I      + S+ L ++  V  GA A++ +G +++ +GT  +A++A+ H+VP  V  E ++F     T  F  ++ D P + + K     A    QN     ++ +L Y    PE + ++IT++G IP
Sbjct:  292 EAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLV-SRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIP-----AASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLL-NLVYDVTPPELVDLVITELGMIP 505
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Celegans
Match: eif-2Balpha (Probable translation initiation factor eIF-2B subunit alpha [Source:UniProtKB/Swiss-Prot;Acc:P34604])

HSP 1 Score: 176.022 bits (445), Expect = 7.354e-53
Identity = 108/294 (36.73%), Postives = 166/294 (56.46%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCK---LDYTCDFKSNL---IKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLS-NYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            ND   +  LATV++L ++++    +T+ E+ + LN  V  L  +DYS   IRSAA+LF RF +      LD   DF   L    ++A  FI  +  S  +I+K +  +     ++L H  SK V E +     + S   L+++V    P  + KL    L  N V    +    + + +E+I AV  GAE V+ +GGIIN+IGT ++ I+A++ HVP YV  E  +F R FPL+Q DIP EF+Y+ SV  +N +L    PD++Y  PE++++IITD+G + P  V EEL K+Y+
Sbjct:   16 NDPSKSTSLATVETLLEVLDRSRATTVAEFQNELNQVVAALEKTDYSSTSIRSAADLFTRFTSLAPAALLDQE-DFSQVLDLYRQRARSFIKNVRGSRAKISKCARLFFTHHMNILTHSYSKVVLETILD--AHKSGYHLHVWVTESQPDASGKLVFEELKKNGVPTTLVLDSCVGYVMERIQAVLVGAEGVMETGGIINKIGTVNVCIIAKSRHVPVYVCAETIKFVREFPLNQADIPQEFKYRTSVIERN-NLELEHPDVDYTAPEFLTLIITDVGAMKPEAVGEELIKMYI 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Fly
Match: eIF2Balpha (gene:FBgn0039726 transcript:FBtr0085508)

HSP 1 Score: 160.999 bits (406), Expect = 7.001e-47
Identity = 95/288 (32.99%), Postives = 163/288 (56.60%), Query Frame = 2 
Query:  101 DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLD-YTCDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNL-SNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            D+  + G+A +++L  ++ +    TI    + +  AV  + N+D S+A I SA ELF RFIT    D +  + +  ++ +  +F+ K+  S   IA+ +  ++     +L H  S+ V +AL    +N  +K  ++YV  G    + +  +++L +  +    I   +  + +E +D V  GAEAVV SGGIIN IGT  + + A+    PFYV+ E F+F+RL+PL+Q+D+P E++Y    R    D++ V P ++Y  P YI+++ TD+G + P  VS+EL KLY+
Sbjct:   24 DKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDLSIAAIVSAGELFCRFITLSLDDKHMEECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCRILTHSRSRVVLKALITASQN--KKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMESVDFVLVGAEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSRLYPLNQRDLPNEYKYS---RKHLNDVSKVHPLVDYTPPVYITLLFTDLGRLTPSAVSDELIKLYM 306
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Fly
Match: CG11334 (gene:FBgn0039849 transcript:FBtr0085808)

HSP 1 Score: 48.521 bits (114), Expect = 4.387e-6
Identity = 32/118 (27.12%), Postives = 51/118 (43.22%), Query Frame = 2 
Query:  611 EQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFP-----LSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKL 949
            + + AV  GA+ V  +G   N+IGT  IA++A+ H VPFYV   +       P     + ++    E  +    R     +    P  +      I+ IIT+ G   P  + E + KL
Sbjct:  244 KNVAAVVVGADRVASNGDTANKIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPAELKEAITKL 361
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Fly
Match: CG11334 (gene:FBgn0039849 transcript:FBtr0085809)

HSP 1 Score: 48.521 bits (114), Expect = 4.387e-6
Identity = 32/118 (27.12%), Postives = 51/118 (43.22%), Query Frame = 2 
Query:  611 EQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFP-----LSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKL 949
            + + AV  GA+ V  +G   N+IGT  IA++A+ H VPFYV   +       P     + ++    E  +    R     +    P  +      I+ IIT+ G   P  + E + KL
Sbjct:  244 KNVAAVVVGADRVASNGDTANKIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPAELKEAITKL 361
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Fly
Match: CG11334 (gene:FBgn0039849 transcript:FBtr0334556)

HSP 1 Score: 48.521 bits (114), Expect = 4.387e-6
Identity = 32/118 (27.12%), Postives = 51/118 (43.22%), Query Frame = 2 
Query:  611 EQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFP-----LSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKL 949
            + + AV  GA+ V  +G   N+IGT  IA++A+ H VPFYV   +       P     + ++    E  +    R     +    P  +      I+ IIT+ G   P  + E + KL
Sbjct:  244 KNVAAVVVGADRVASNGDTANKIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPAELKEAITKL 361
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Zebrafish
Match: eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 alpha [Source:ZFIN;Acc:ZDB-GENE-040625-25])

HSP 1 Score: 188.734 bits (478), Expect = 1.673e-57
Identity = 109/300 (36.33%), Postives = 175/300 (58.33%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKL---KIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A ++SL + +    + TI      +  A+  L  +D S+A + S  ELF+RFI+   L++      K+ +I++ +LF+ KI+ S  ++ KL ++++K  + +L H  S+ V + L +   +N  K+  +YV    P    KL   K+R LS  V++V +D  ++ + LE++D V  GAE VV SGG+IN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFRGQIREDPDVASAVAAIRSLLEFLKRDQSETILGLRENMTQAIHRLQEADSSVA-VSSGGELFLRFISLTSLEHPDLSQCKNVMIERGELFLKKISLSRGKVGKLCHTFIKDGAKILTHSSSRVVLKVLENAAADN--KRFTVYVTESQPDSAGKLMAEKLRKLSIPVTVV-LDA-AVGYILEKVDLVIVGAEGVVESGGVINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPDRFKYKADVLKTAEDLNQEHPLIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Zebrafish
Match: eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 alpha [Source:ZFIN;Acc:ZDB-GENE-040625-25])

HSP 1 Score: 188.734 bits (478), Expect = 1.673e-57
Identity = 109/300 (36.33%), Postives = 175/300 (58.33%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKL---KIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A ++SL + +    + TI      +  A+  L  +D S+A + S  ELF+RFI+   L++      K+ +I++ +LF+ KI+ S  ++ KL ++++K  + +L H  S+ V + L +   +N  K+  +YV    P    KL   K+R LS  V++V +D  ++ + LE++D V  GAE VV SGG+IN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFRGQIREDPDVASAVAAIRSLLEFLKRDQSETILGLRENMTQAIHRLQEADSSVA-VSSGGELFLRFISLTSLEHPDLSQCKNVMIERGELFLKKISLSRGKVGKLCHTFIKDGAKILTHSSSRVVLKVLENAAADN--KRFTVYVTESQPDSAGKLMAEKLRKLSIPVTVV-LDA-AVGYILEKVDLVIVGAEGVVESGGVINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPDRFKYKADVLKTAEDLNQEHPLIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Zebrafish
Match: eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 alpha [Source:ZFIN;Acc:ZDB-GENE-040625-25])

HSP 1 Score: 187.193 bits (474), Expect = 4.356e-57
Identity = 106/296 (35.81%), Postives = 172/296 (58.11%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A ++SL + +    + TI      +  A+  L  +D S+A + S  ELF+RFI+   L++      K+ +I++ +LF+ KI+ S  ++ KL ++++K  + +L H  S+ V + L +   +N R     + + L  E    K+R LS  V++V +D  ++ + LE++D V  GAE VV SGG+IN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFRGQIREDPDVASAVAAIRSLLEFLKRDQSETILGLRENMTQAIHRLQEADSSVA-VSSGGELFLRFISLTSLEHPDLSQCKNVMIERGELFLKKISLSRGKVGKLCHTFIKDGAKILTHSSSRVVLKVLENAAADNKR-----FTVKLMAE----KLRKLSIPVTVV-LDA-AVGYILEKVDLVIVGAEGVVESGGVINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPDRFKYKADVLKTAEDLNQEHPLIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 291
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Zebrafish
Match: eif2b2 (eukaryotic translation initiation factor 2B, subunit 2 beta [Source:ZFIN;Acc:ZDB-GENE-040426-2605])

HSP 1 Score: 52.373 bits (124), Expect = 2.827e-7
Identity = 52/223 (23.32%), Postives = 106/223 (47.53%), Query Frame = 2 
Query:  314 FKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKI-----SISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKD-----LTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLY 952
             K+N+I+  +  + ++  + D I+  +  ++ S   ++  G S+TV EA    +K+ +RK+   +VI      + L    ++  +S  +I+       +I   + +++ V  G + V+ +GG+    GT  +A+ A+ H  P  V   +F+ +  FP ++ D   +F     V    +      + A  P  +YV PE I++ I++IG   P  +   + +LY
Sbjct:  133 LKANVIEAINELLTELEGTTDNISMQALEHIHSNEVIMTIGRSRTV-EAF---LKDAARKR-KFHVIVAECAPFCLG-HEMATSLSKEDIETTVIPDAAIFAVMSRVNKVIIGTQTVLANGGLRAVNGTHTLALAAKHHSTPLIVCAPMFKLSPQFP-NEDDTFHKFVSPHEVLPFTEGEILSKVNAHCPVFDYVPPELITLFISNIGGHAPSYIYRLMSELY 348
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Zebrafish
Match: eif2b2 (eukaryotic translation initiation factor 2B, subunit 2 beta [Source:ZFIN;Acc:ZDB-GENE-040426-2605])

HSP 1 Score: 52.373 bits (124), Expect = 2.827e-7
Identity = 52/223 (23.32%), Postives = 106/223 (47.53%), Query Frame = 2 
Query:  314 FKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKI-----SISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKD-----LTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLY 952
             K+N+I+  +  + ++  + D I+  +  ++ S   ++  G S+TV EA    +K+ +RK+   +VI      + L    ++  +S  +I+       +I   + +++ V  G + V+ +GG+    GT  +A+ A+ H  P  V   +F+ +  FP ++ D   +F     V    +      + A  P  +YV PE I++ I++IG   P  +   + +LY
Sbjct:  133 LKANVIEAINELLTELEGTTDNISMQALEHIHSNEVIMTIGRSRTV-EAF---LKDAARKR-KFHVIVAECAPFCLG-HEMATSLSKEDIETTVIPDAAIFAVMSRVNKVIIGTQTVLANGGLRAVNGTHTLALAAKHHSTPLIVCAPMFKLSPQFP-NEDDTFHKFVSPHEVLPFTEGEILSKVNAHCPVFDYVPPELITLFISNIGGHAPSYIYRLMSELY 348
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Xenopus
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:550040])

HSP 1 Score: 168.318 bits (425), Expect = 1.849e-49
Identity = 105/302 (34.77%), Postives = 167/302 (55.30%), Query Frame = 2 
Query:   80 KFNEYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            K  +YF      D      +A +++L + +   +  TI      L +A   L+  D S++ + S  ELF+RFIT        D+   K  + ++ +LF+ +I+ S ++I  L   ++K  + +L H  SK V + L     N   K  ++YV    P  + K+ +  L N  V +  I   ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+Q+D+P +F+YKA  + QNKDL    P ++Y  P  I+++ TD+G + P  +S+EL KLYL
Sbjct:    3 KIVQYFKCQLQEDTDVATAVAAIRTLLEFLKRDTGETIQGLIGSLKDATGTLSKVDSSVS-VSSGGELFLRFITLTSNLEHSDYDKCKKMMSERGELFLKRISMSRNKITTLCCPFIKDGAKILTHAYSKVVLKVLEEAAAN---KNFSVYVTESQPDLSGKIMVEALRNRNVPVTLILDAAVGYIMEKVDLVIVGAEGVVESGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQRDVPDKFKYKADTQQQNKDLLEEHPWIDYTSPSLITLLFTDLGVLTPSAISDELIKLYL 300
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Xenopus
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:550040])

HSP 1 Score: 167.548 bits (423), Expect = 2.507e-49
Identity = 101/284 (35.56%), Postives = 162/284 (57.04%), Query Frame = 2 
Query:  119 GLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
             +A +++L + +   +  TI      L +A   L+  D S++ + S  ELF+RFIT        D+   K  + ++ +LF+ +I+ S ++I  L   ++K  + +L H  SK V + L     N   K  ++YV    P  + K+ +  L N  V +  I   ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+Q+D+P +F+YKA  + QNKDL    P ++Y  P  I+++ TD+G + P  +S+EL KLYL
Sbjct:   12 AVAAIRTLLEFLKRDTGETIQGLIGSLKDATGTLSKVDSSVS-VSSGGELFLRFITLTSNLEHSDYDKCKKMMSERGELFLKRISMSRNKITTLCCPFIKDGAKILTHAYSKVVLKVLEEAAAN---KNFSVYVTESQPDLSGKIMVEALRNRNVPVTLILDAAVGYIMEKVDLVIVGAEGVVESGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQRDVPDKFKYKADTQQQNKDLLEEHPWIDYTSPSLITLLFTDLGVLTPSAISDELIKLYL 291
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Xenopus
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:550040])

HSP 1 Score: 167.933 bits (424), Expect = 4.662e-49
Identity = 102/290 (35.17%), Postives = 163/290 (56.21%), Query Frame = 2 
Query:  101 DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            D      +A +++L + +   +  TI      L +A   L+  D S++ + S  ELF+RFIT        D+   K  + ++ +LF+ +I+ S ++I  L   ++K  + +L H  SK V + L     N   K  ++YV    P  + K+ +  L N  V +  I   ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+Q+D+P +F+YKA  + QNKDL    P ++Y  P  I+++ TD+G + P  +S+EL KLYL
Sbjct:   37 DTDVATAVAAIRTLLEFLKRDTGETIQGLIGSLKDATGTLSKVDSSVS-VSSGGELFLRFITLTSNLEHSDYDKCKKMMSERGELFLKRISMSRNKITTLCCPFIKDGAKILTHAYSKVVLKVLEEAAAN---KNFSVYVTESQPDLSGKIMVEALRNRNVPVTLILDAAVGYIMEKVDLVIVGAEGVVESGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQRDVPDKFKYKADTQQQNKDLLEEHPWIDYTSPSLITLLFTDLGVLTPSAISDELIKLYL 322
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Xenopus
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:550040])

HSP 1 Score: 119.013 bits (297), Expect = 2.049e-30
Identity = 79/239 (33.05%), Postives = 130/239 (54.39%), Query Frame = 2 
Query:  101 DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFR 802
            D      +A +++L + +   +  TI      L +A   L+  D S++ + S  ELF+RFIT        D+   K  + ++ +LF+ +I+ S ++I  L   ++K  + +L H  SK V + L     N   K  ++YV    P  + K+ +  L N  V +  I   ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+Q+D+P +F+
Sbjct:   71 DTDVATAVAAIRTLLEFLKRDTGETIQGLIGSLKDATGTLSKVDSSVS-VSSGGELFLRFITLTSNLEHSDYDKCKKMMSERGELFLKRISMSRNKITTLCCPFIKDGAKILTHAYSKVVLKVLEEAAAN---KNFSVYVTESQPDLSGKIMVEALRNRNVPVTLILDAAVGYIMEKVDLVIVGAEGVVESGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQRDVPDKFK 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Mouse
Match: Eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 (alpha) [Source:MGI Symbol;Acc:MGI:2384802])

HSP 1 Score: 173.326 bits (438), Expect = 1.669e-51
Identity = 105/303 (34.65%), Postives = 175/303 (57.76%), Query Frame = 2 
Query:   89 EYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKA----SVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D K    +A +++L + +      T+    + L  A+  L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  + +L H  S+ V   L   V   ++K+ ++Y+    P  + K   + LS+  V +  +   ++ + +E+ D V  GAE VV +GGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+Q+D+P +F+YKA    SV+   +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQGLRANLTYAIKTLCGVDSSVA-VSSGGELFLRFISLTSLEYS-DYSKCKKIMIERGELFLRRISLSRNKIANLCHTFIKDGARILTHAYSRVVLRVLEEAVA--AKKRFSVYITESQPDLSGKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSVQT-GQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Mouse
Match: Eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 (alpha) [Source:MGI Symbol;Acc:MGI:2384802])

HSP 1 Score: 62.003 bits (149), Expect = 4.404e-11
Identity = 42/149 (28.19%), Postives = 80/149 (53.69%), Query Frame = 2 
Query:   89 EYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYV 511
            EYF      D K    +A +++L + +      T+    + L  A+  L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  + +L H  S+ V   L   V   ++K+ ++Y+
Sbjct:    8 EYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQGLRANLTYAIKTLCGVDSSVA-VSSGGELFLRFISLTSLEYS-DYSKCKKIMIERGELFLRRISLSRNKIANLCHTFIKDGARILTHAYSRVVLRVLEEAV--AAKKRFSVYI 152
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Mouse
Match: Eif2b4 (eukaryotic translation initiation factor 2B, subunit 4 delta [Source:MGI Symbol;Acc:MGI:95300])

HSP 1 Score: 53.5286 bits (127), Expect = 9.050e-8
Identity = 31/120 (25.83%), Postives = 62/120 (51.67%), Query Frame = 2 
Query:  593 SISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRF-----TRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVR-------PEYISMIITDIGCIP 916
            + S+ L ++  V  GA A++ +G +++ +GT  +A++A+ H+VP  V  E ++F     T  F  ++ D P + + K   +    +  +  P L  +        PE + ++IT++G IP
Sbjct:  112 AASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGDQVALANWQS-HPSLRLLNLVYDVTPPELVDLVITELGMIP 230
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Mouse
Match: Eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 (alpha) [Source:MGI Symbol;Acc:MGI:2384802])

HSP 1 Score: 51.2174 bits (121), Expect = 1.020e-7
Identity = 35/122 (28.69%), Postives = 66/122 (54.10%), Query Frame = 2 
Query:   62 SFKISDKFNEYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSY 403
            S+  ++K  EYF      D K    +A +++L + +      T+    + L  A+  L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L +++
Sbjct:   14 SYVPANKLIEYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQGLRANLTYAIKTLCGVDSSVA-VSSGGELFLRFISLTSLEYS-DYSKCKKIMIERGELFLRRISLSRNKIANLCHTF 133
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Mouse
Match: Eif2b4 (eukaryotic translation initiation factor 2B, subunit 4 delta [Source:MGI Symbol;Acc:MGI:95300])

HSP 1 Score: 53.9138 bits (128), Expect = 1.233e-7
Identity = 50/225 (22.22%), Postives = 103/225 (45.78%), Query Frame = 2 
Query:  311 DFKSNLIKKADLFIA-KITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDK-----ISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRF-----TRLFPLSQQDIPTEFRYKASVRAQNKDLTAVM-----PDLEYVR-------PEYISMIITDIGCIP 916
            + KS L +  D ++  KI  +   I++ +++ +     +LV+G S  V   +    +   R+   + V   P    +L+ R++ + +    +        + S+ L ++  V  GA A++ +G +++ +GT  +A++A+ H+VP  V  E ++F     T  F  ++ D P + + K        D  A+      P L  +        PE + ++IT++G IP
Sbjct:  296 EAKSELREALDRYVQEKIVLAAQAISRFASTKISDGDVILVYGCSSLVSR-ILQEARVEGRRFRVVVVDSRP----RLEGRHMLHSLVRAGVPTSYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCK------RGDQVALANWQSHPSLRLLNLVYDVTPPELVDLVITELGMIP 509
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. UniProt/SwissProt
Match: sp|Q5RAR0|EI2BA_PONAB (Translation initiation factor eIF-2B subunit alpha OS=Pongo abelii OX=9601 GN=EIF2B1 PE=2 SV=2)

HSP 1 Score: 176.407 bits (446), Expect = 8.679e-52
Identity = 105/302 (34.77%), Postives = 174/302 (57.62%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKA---SVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  +++L H  S+ V   L   V   ++K+ ++YV    P  + K   + L +  V +  +   ++ + +E+ D V  GAE VV +GGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+QQD+P +F+YKA    V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLASLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVA--AKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. UniProt/SwissProt
Match: sp|Q14232|EI2BA_HUMAN (Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1)

HSP 1 Score: 176.407 bits (446), Expect = 8.679e-52
Identity = 105/302 (34.77%), Postives = 174/302 (57.62%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKA---SVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  +++L H  S+ V   L   V   ++K+ ++YV    P  + K   + L +  V +  +   ++ + +E+ D V  GAE VV +GGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+QQD+P +F+YKA    V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLASLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVA--AKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. UniProt/SwissProt
Match: sp|P34604|EI2BA_CAEEL (Probable translation initiation factor eIF-2B subunit alpha OS=Caenorhabditis elegans OX=6239 GN=ZK1098.4 PE=1 SV=1)

HSP 1 Score: 176.022 bits (445), Expect = 9.354e-52
Identity = 108/294 (36.73%), Postives = 166/294 (56.46%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCK---LDYTCDFKSNL---IKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLS-NYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            ND   +  LATV++L ++++    +T+ E+ + LN  V  L  +DYS   IRSAA+LF RF +      LD   DF   L    ++A  FI  +  S  +I+K +  +     ++L H  SK V E +     + S   L+++V    P  + KL    L  N V    +    + + +E+I AV  GAE V+ +GGIIN+IGT ++ I+A++ HVP YV  E  +F R FPL+Q DIP EF+Y+ SV  +N +L    PD++Y  PE++++IITD+G + P  V EEL K+Y+
Sbjct:   16 NDPSKSTSLATVETLLEVLDRSRATTVAEFQNELNQVVAALEKTDYSSTSIRSAADLFTRFTSLAPAALLDQE-DFSQVLDLYRQRARSFIKNVRGSRAKISKCARLFFTHHMNILTHSYSKVVLETILD--AHKSGYHLHVWVTESQPDASGKLVFEELKKNGVPTTLVLDSCVGYVMERIQAVLVGAEGVMETGGIINKIGTVNVCIIAKSRHVPVYVCAETIKFVREFPLNQADIPQEFKYRTSVIERN-NLELEHPDVDYTAPEFLTLIITDVGAMKPEAVGEELIKMYI 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. UniProt/SwissProt
Match: sp|Q64270|EI2BA_RAT (Translation initiation factor eIF-2B subunit alpha OS=Rattus norvegicus OX=10116 GN=Eif2b1 PE=2 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 2.065e-51
Identity = 103/295 (34.92%), Postives = 173/295 (58.64%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKA----SVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
             D      +A +++L + +      TI    + L  A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+++I+ S  +IA L ++++K  + +L H  S+ V   L   V   ++K+ ++Y+    P  + K   + L +  V +  +   ++ + +E++D V  GAE VV +GGIIN+IGT  +A+ A+  + PFYVV E F+F RLFPL+QQD+P +F+YKA    SV+A  +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:   16 GDPNMASAVAAIQTLLEFLKRDKGETIQGLRAHLTKAIETLCAVDSSVA-VSSGGELFLRFISLTSLEYS-DYSKCKKIMIERGELFLSRISLSRTKIASLCHAFIKDGARILTHAYSRVVLRVLEEAVA--AKKRFSVYITESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQA-GQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. UniProt/SwissProt
Match: sp|Q4R4V8|EI2BA_MACFA (Translation initiation factor eIF-2B subunit alpha OS=Macaca fascicularis OX=9541 GN=EIF2B1 PE=2 SV=1)

HSP 1 Score: 174.481 bits (441), Expect = 3.840e-51
Identity = 104/302 (34.44%), Postives = 173/302 (57.28%), Query Frame = 2 
Query:   89 EYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKA---SVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A +++L + +      TI    + L +A++ L   D S+A + S  ELF+RFI+   L+Y+ D+   K  +I++ +LF+ +I+ S ++IA L ++++K  +++L H  S+ V   L   V   ++K+ ++YV    P  + K   + L +  V +  +   ++ + +E+ D V  GAE VV +GGIIN+IGT  +A+ A+  + PFY V E F+F RLFPL+QQD+P +F+YKA    V    +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVA-VSSGGELFLRFISLTSLEYS-DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVA--AKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYAVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. TrEMBL
Match: A0A067R0C8 (Translation initiation factor eIF-2B subunit alpha OS=Zootermopsis nevadensis OX=136037 GN=L798_14843 PE=3 SV=1)

HSP 1 Score: 204.912 bits (520), Expect = 2.208e-60
Identity = 107/291 (36.77%), Postives = 178/291 (61.17%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTC--DFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNL---SNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            N++  + G+A +++L +++   ++ T+ E DS L  AVD + N+DY +  + S  ELF+RFIT  KLD     + KS ++ +  LF+ K+ ++  ++AKL++S++   S VL H  S+ V   +    + N  K+  +Y+     +N  +++R L    N    V +D  +I + +EQ+D V  GAE VV SGGIIN++G+  +A+ A+    PFYV+TE F+F RL+PL+Q+D+P EF+Y +S     +DL+   P ++Y  P YI+++ TD+G + P  VS+EL KLYL
Sbjct:   29 NEQDVSAGMAAIRTLLNVLERDTSETVQELDSNLQAAVDAMKNTDYPVTAVASGCELFLRFITLAKLDTKTFGECKSIMLHRGQLFLKKLMEARGKVAKLASSFIVDGSRVLTHSKSRVVLHGMKEAARAN--KRFEVYITMSSPDNSGVEMRRLLEEENIPCTVILDS-AIGYVMEQVDMVMVGAEGVVESGGIINKVGSYTMAVCAREMKKPFYVLTESFKFVRLYPLNQRDLPNEFKYTSS--KLGRDLSKEHPLVDYTPPSYITLLFTDLGILTPSAVSDELIKLYL 314
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. TrEMBL
Match: A0A2J7Q3Q7 (Translation initiation factor eIF-2B subunit alpha OS=Cryptotermes secundus OX=105785 GN=B7P43_G02740 PE=3 SV=1)

HSP 1 Score: 204.142 bits (518), Expect = 4.490e-60
Identity = 114/306 (37.25%), Postives = 182/306 (59.48%), Query Frame = 2 
Query:   56 MSSFKISDKFNEYFNDEK-CTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTC--DFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNL---SNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            M   +I + F      E+  + G+A +++L  ++   ++ T+ E DS L  AVD + N+DY +  + S  ELF+RFIT  KLD     + KS ++ +  LF+ K+ ++  ++AKL++S++   S VL+H  S+ V  A+    + N  K+  +YV     +N  L++  L    N    V +D  ++ + +EQ+D V  GAE VV SGGIIN++G+  +AI A+    PFYV+TE F+F RL+PL+Q+D+P EF+Y +S     KDLT   P ++Y  P YI+++ TD+G + P  VS+EL KLYL
Sbjct:    5 MKKKEIEEVFGGILEKEQDVSAGMAAIRTLLTVLEHDTSETVQELDSNLQAAVDAMKNTDYPVTAVASGCELFLRFITLAKLDTKTFGECKSIMLHRGQLFLKKLMEARGKVAKLASSFIVDGSRVLIHSKSRVVLHAMKEAARAN--KRFEVYVTMSSPDNSGLEMCRLLEEENIPCTVILDS-AVGYVMEQVDMVMAGAEGVVESGGIINKVGSYTMAICAREMKKPFYVLTESFKFVRLYPLNQRDLPNEFKYTSS--KLGKDLTKEHPLVDYTPPSYITLLFTDLGILTPSAVSDELIKLYL 305
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. TrEMBL
Match: A0A1B6CXV9 (Uncharacterized protein OS=Clastoptera arizonana OX=38151 GN=g.5771 PE=3 SV=1)

HSP 1 Score: 196.052 bits (497), Expect = 4.631e-57
Identity = 109/306 (35.62%), Postives = 179/306 (58.50%), Query Frame = 2 
Query:   56 MSSFKISDKFNEYFNDEK-CTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTC--DFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLS--NYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            M   +I + F      EK  + G+A +++L   +    + T+ E D+ L  A+D++   D  +  + S +ELF+RFITF  LD+    D K  ++ +  +F+ K+ ++  ++AKL   ++   S VL H  S+ V E +    K N  K+  +Y+    P  +  +  ++L   N    V +D  ++++ +EQ+D V  GAE VV SGGIIN++G+  +A+ A+    PFYV+TE F+FTRLFPL+Q+D+P EF+Y +S+   +KDL+   P ++Y  P YIS++ TD+G + P  VS+EL KLYL
Sbjct:    1 MDKLEIENVFLGIMRKEKEVSAGVAAIRTLLKFLEHDKSETLQELDANLKTAIDVMQKLDCPVTAVASGSELFLRFITFATLDFKTFMDCKRIMLHRGQVFLKKLMEARGKVAKLGAGFITDGSQVLTHSKSRVVLETMKEAAKAN--KRFEVYITQSSPDSSGDIMAKDLEKLNIPCTVILDS-AVAYVMEQVDMVMVGAEGVVESGGIINKVGSFTMAVCAREMKKPFYVLTESFKFTRLFPLNQRDLPNEFKYTSSML--DKDLSKQHPLVDYTPPAYISLLFTDLGILTPSAVSDELIKLYL 301
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. TrEMBL
Match: A0A0N7Z9A6 (Putative translation initiation factor eif-2b subunit alpha OS=Rhodnius neglectus OX=72488 PE=2 SV=1)

HSP 1 Score: 193.356 bits (490), Expect = 5.441e-56
Identity = 109/292 (37.33%), Postives = 177/292 (60.62%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI----GLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            ND++ + G+A + +L   +    + TI E  + L  AV I+ ++D  +  + S +ELF+RFIT   LDY+   D K  ++ + ++F+ K+ ++  ++AKL +S++   S VL H  S+ V+E      K+N  K+ ++YV         E    ++R + N    V +D  +I + +EQ+D V  GAE VV SGG+IN++G+  +A+ A+    PFYV+TE F+F+RL+PL+Q+D+P EF+YK S  A  KDL+   P ++Y  P YIS++ TD+G + P  VS+EL KLYL
Sbjct:   16 NDKQVSAGIAAICTLLKYLEHDKSETIQELVTKLKRAVKIMRSTDCPITAVVSGSELFLRFITLATLDYSTFADCKKIMLHRGEVFLNKLKEARGKVAKLGSSFIVDGSKVLTHSKSRVVYETFKEATKSN--KRFHVYVTRSSPDSSGEEMAEELRKM-NIPCTVILDS-AIGYVMEQMDIVMIGAEGVVESGGVINKVGSYTMALCAREMKKPFYVLTESFKFSRLYPLNQRDLPDEFKYKWS--ALKKDLSQEHPLVDYTPPSYISLLFTDLGILTPSAVSDELIKLYL 301
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. TrEMBL
Match: R4G4Q4 (Putative eukaryotic translation initiation factor 2b OS=Rhodnius prolixus OX=13249 PE=2 SV=1)

HSP 1 Score: 193.356 bits (490), Expect = 5.441e-56
Identity = 109/292 (37.33%), Postives = 177/292 (60.62%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI----GLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            ND++ + G+A + +L   +    + TI E  + L  AV I+ ++D  +  + S +ELF+RFIT   LDY+   D K  ++ + ++F+ K+ ++  ++AKL +S++   S VL H  S+ V+E      K+N  K+ ++YV         E    ++R + N    V +D  +I + +EQ+D V  GAE VV SGG+IN++G+  +A+ A+    PFYV+TE F+F+RL+PL+Q+D+P EF+YK S  A  KDL+   P ++Y  P YIS++ TD+G + P  VS+EL KLYL
Sbjct:   16 NDKQVSAGIAAICTLLKYLEHDKSETIQELVTKLKRAVKIMRSTDCPITAVVSGSELFLRFITLATLDYSTFADCKKIMLHRGEVFLNKLKEARGKVAKLGSSFIVDGSKVLTHSKSRVVYETFKEATKSN--KRFHVYVTRSSPDSSGEEMAEELRKM-NIPCTVILDS-AIGYVMEQMDIVMIGAEGVVESGGVINKVGSYTMALCAREMKKPFYVLTESFKFSRLYPLNQRDLPDEFKYKWS--ALKKDLSQEHPLVDYTPPSYISLLFTDLGILTPSAVSDELIKLYL 301
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Cavefish
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:103047756])

HSP 1 Score: 182.185 bits (461), Expect = 4.137e-55
Identity = 108/304 (35.53%), Postives = 174/304 (57.24%), Query Frame = 2 
Query:   77 DKFNEYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKL---KIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            +K  EYF      D      +A ++SL + +    + TI      L  A+  L  +D S+A + S  ELF+RFI+   L+       ++ +I++ +LF+ KI+ S  ++AKL ++++K  + +L H  S+ V + L     +  +K+  +YV    P    K    K+R L+  V+IV +D  ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA      +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    2 NKLVEYFRTQMSQDPDVASAVAAIRSLLEFLKRDQSETILGLRENLTKAIGRLQEADSSVA-VSSGGELFLRFISLTSLENPDLSQCRNMMIERGELFLKKISLSRGKVAKLCHTFIKDGAKILTHSSSRVVLKVLESAAAD--KKRFTVYVTESQPDSAGKHMADKLRKLNIPVTIV-LDA-AVGYIMEKVDMVIVGAEGVVESGGIINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPHRFKYKADTLKTAEDLNQEHPIIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 300
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Cavefish
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:103047756])

HSP 1 Score: 181.03 bits (458), Expect = 1.377e-54
Identity = 107/300 (35.67%), Postives = 172/300 (57.33%), Query Frame = 2 
Query:   89 EYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKL---KIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A ++SL + +    + TI      L  A+  L  +D S+A + S  ELF+RFI+   L+       ++ +I++ +LF+ KI+ S  ++AKL ++++K  + +L H  S+ V + L     +  +K+  +YV    P    K    K+R L+  V+IV +D  ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA      +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFRTQMSQDPDVASAVAAIRSLLEFLKRDQSETILGLRENLTKAIGRLQEADSSVA-VSSGGELFLRFISLTSLENPDLSQCRNMMIERGELFLKKISLSRGKVAKLCHTFIKDGAKILTHSSSRVVLKVLESAAAD--KKRFTVYVTESQPDSAGKHMADKLRKLNIPVTIV-LDA-AVGYIMEKVDMVIVGAEGVVESGGIINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPHRFKYKADTLKTAEDLNQEHPIIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Cavefish
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:103047756])

HSP 1 Score: 181.03 bits (458), Expect = 1.377e-54
Identity = 107/300 (35.67%), Postives = 172/300 (57.33%), Query Frame = 2 
Query:   89 EYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKL---KIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A ++SL + +    + TI      L  A+  L  +D S+A + S  ELF+RFI+   L+       ++ +I++ +LF+ KI+ S  ++AKL ++++K  + +L H  S+ V + L     +  +K+  +YV    P    K    K+R L+  V+IV +D  ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA      +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFRTQMSQDPDVASAVAAIRSLLEFLKRDQSETILGLRENLTKAIGRLQEADSSVA-VSSGGELFLRFISLTSLENPDLSQCRNMMIERGELFLKKISLSRGKVAKLCHTFIKDGAKILTHSSSRVVLKVLESAAAD--KKRFTVYVTESQPDSAGKHMADKLRKLNIPVTIV-LDA-AVGYIMEKVDMVIVGAEGVVESGGIINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPHRFKYKADTLKTAEDLNQEHPIIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Cavefish
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:103047756])

HSP 1 Score: 181.03 bits (458), Expect = 1.377e-54
Identity = 107/300 (35.67%), Postives = 172/300 (57.33%), Query Frame = 2 
Query:   89 EYF-----NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKL---KIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            EYF      D      +A ++SL + +    + TI      L  A+  L  +D S+A + S  ELF+RFI+   L+       ++ +I++ +LF+ KI+ S  ++AKL ++++K  + +L H  S+ V + L     +  +K+  +YV    P    K    K+R L+  V+IV +D  ++ + +E++D V  GAE VV SGGIIN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P  F+YKA      +DL    P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    8 EYFRTQMSQDPDVASAVAAIRSLLEFLKRDQSETILGLRENLTKAIGRLQEADSSVA-VSSGGELFLRFISLTSLENPDLSQCRNMMIERGELFLKKISLSRGKVAKLCHTFIKDGAKILTHSSSRVVLKVLESAAAD--KKRFTVYVTESQPDSAGKHMADKLRKLNIPVTIV-LDA-AVGYIMEKVDMVIVGAEGVVESGGIINKIGTYQMAVCSKAHNKPFYVVAESFKFVRLYPLNQQDVPHRFKYKADTLKTAEDLNQEHPIIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Cavefish
Match: eif2b4 (eukaryotic translation initiation factor 2B, subunit 4 delta [Source:ZFIN;Acc:ZDB-GENE-030131-955])

HSP 1 Score: 56.9954 bits (136), Expect = 9.849e-9
Identity = 68/276 (24.64%), Postives = 126/276 (45.65%), Query Frame = 2 
Query:  143 RDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFI-AKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSN------YVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRF-----TRLFPLSQQDIPTEF----RYKASVRAQNKDLTAVMPDLEY--VRPEYISMIITDIGCIP 916
            RDL+N+     +  Y S LN    + A+   ++  I+          + CK +   + K  L+   D ++  KIT +   I+K +   +     +LV+G S  V   L    +   RK   I V   P    +  +R L N      YV I      ++S+ L ++  VF GA A++ +G +++ +GT  IA++A+ ++VP  V  E ++F     T  F  ++ D P +     + K  +     + +  + +L Y    P+++ ++IT++G IP
Sbjct:  235 RDLVNK-----LKPYISFLNQCRPLSASMGNAIKYIKKE---ISNIPSQCKEE---EAKKKLLSCVDSYVNEKITLAAKGISKYAIDKISDGDVILVYGCSSLVNHILCEAFEKQ-RKFRVIVVDSRPRLEGREALRRLVNRGIRCTYVLIS-----AVSYVLPEVSKVFLGAHALLANGYVMSRVGTSQIALVAKAYNVPVLVCCETYKFCERVQTDSFVSNELDDPDDLIVTRKGKTHLADWQSETSLGLLNLVYDVTPPDFVDLVITELGMIP 493
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Sea Lamprey
Match: eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 alpha [Source:ZFIN;Acc:ZDB-GENE-040625-25])

HSP 1 Score: 177.563 bits (449), Expect = 5.795e-54
Identity = 100/292 (34.25%), Postives = 173/292 (59.25%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIEN---YKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
             D      +A +++L   +   +  T+      L + + +L+  D S++ + S  ELF+R IT  KLD     + +  LI++ +LF++KI+ S ++IAK+S S+++  +++L H  S+ V   L       S+K+ ++YV    P  +      +IR LS  V+++ +D  ++ + +EQ+D VF GAE VV SGGIIN+IGT  +AI A+  + P YVV E F+F RL+PL+QQD+P +++Y+  V   N+  +   P  +Y  P +++++ITD+G + P  VS+EL +LY+
Sbjct:   16 QDPDNPSAVAAIRTLIHFLKRDTGETLQGLRESLKSIMRLLSGIDASVS-MSSCCELFLRTITLTKLDEKPIAECRQILIERGELFLSKISDSRNKIAKMSQSFIRDGATILTHSSSRVVLRVLAEAAA--SKKRFHVYVTESCPDRSGHAMAQRIRELSVPVTVI-LDA-AVGYIMEQVDLVFVGAEGVVESGGIINKIGTYQMAICAKAQNKPLYVVAESFKFMRLYPLNQQDVPEKYKYEPDVLLSNEARSGAHPRTDYTAPAFLTLLITDLGVLTPSAVSDELIQLYV 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Sea Lamprey
Match: eif2b4 (eukaryotic translation initiation factor 2B, subunit 4 delta [Source:ZFIN;Acc:ZDB-GENE-030131-955])

HSP 1 Score: 58.5362 bits (140), Expect = 4.868e-10
Identity = 63/313 (20.13%), Postives = 132/313 (42.17%), Query Frame = 2 
Query:   53 FMSSFK-ISDKFNEYFNDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSL---APIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNY-VSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRF-----------TRLFPLSQQDIPTEFRYKASVRAQNKDLTAV--MPDLEYVR-------PEYISMIITDIGCIP 916
             + +FK +   ++   N++ C + +  +K     +N+C    ++     + NA+  L +   S+    P R A EL             CD+  + ++       KI  +   IA  +   +K   ++LV+G S  V   L    +   R    + V   P    +  +R L  + V    +   ++++ ++++  VF GA A++ +G +++ +G+  + ++A+ ++VP  +  E ++F             L     QD P         R     L+    +P L+ +        P++++M+ITD+G IP
Sbjct:   91 LLHAFKQVIRDYSTPLNEDLCRDLVNKLKPDISFLNQCRPLAVS-----MGNAIKHLKSCISSIPAGTPERQAKELL------------CDWIDSFVQN------KIELAAKAIADFAIQKIKDGDTILVYGCSSLVNRVLVE-ARMRGRTFRVVLVDSRPRMEAREAMRRLVRHGVPCTYVLVTALAYAMQEVSKVFLGAHALLANGYVMSRLGSSQVTLVAKAYNVPVLICCETYKFCERVQTDSFVSNELGNSVSQDDPDNL---VCSRGDETPLSGWRDVPSLKLLNLVYDVTPPDFVAMVITDVGMIP 376
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Sea Lamprey
Match: eif2b2 (eukaryotic translation initiation factor 2B, subunit 2 beta [Source:ZFIN;Acc:ZDB-GENE-040426-2605])

HSP 1 Score: 47.7506 bits (112), Expect = 1.243e-6
Identity = 49/222 (22.07%), Postives = 100/222 (45.05%), Query Frame = 2 
Query:  311 DFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIG--LPI-ENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVR--AQNKDLTAVM---PDLEYVRPEYISMIITDIGCIPPCNVSEELFKLY 952
              K  +I+  +  + ++  S+D IA  +  ++ S   ++  G S+TV   L    K  +RK+    ++    P     KL +      +    I   +I   + +++ V  G   V+ +GG+    G + +A+ A+ +  P  V   +++ +  FP ++ D   +F     V   ++ + L+ V    P  +YV PE I++ I++IG   P  +   + +LY
Sbjct:   75 QLKPIVIEAINELLLELEGSVDNIAMQALEHIHSNEVIMTMGMSRTVDAFL----KEAARKRKFHVIVAECAPFCHGQKLAVSLAKVGIETTLITDAAIFAMMSRVNKVILGTHTVLANGGLKAVNGAQTLALAAKHYSTPVIVCAHMYKLSPQFP-NEHDAFHKFVSPQEVLPFSEGEILSKVSVYCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELY 291
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Yeast
Match: GCN3 (Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p, Gcd6p, Gcd7p, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions; human homolog EIF2B1 can complement yeast null mutant [Source:SGD;Acc:S000001734])

HSP 1 Score: 136.732 bits (343), Expect = 1.628e-38
Identity = 91/305 (29.84%), Postives = 156/305 (51.15%), Query Frame = 2 
Query:   56 MSSFKISDKFNEYFN-DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDF---KSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVM--PDLEYVRPEYISMIITDIGCIPPCNVSEELFKLY 952
            MS F I++ +  +   D + T  +A +++L  L+   +  T  E  + + ++ + L  S  +   +R+  ++FMRF+    L    D+   K +LI+   LF+++  KS ++IA++   ++     +LVHG S+ V+  L H      R +  +       +  +L        + +  I   ++   ++++D VF GAE V  SGGIIN +GT  + +LA     PFYVVTE  +F R+FPLS  D+P         R +  DL   +  P ++Y   EYI+ +ITD+G + P  VSEEL K++
Sbjct:    1 MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFV-LRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLDFTR-RTDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEELIKMW 303
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Nematostella
Match: EDO35087 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMK4])

HSP 1 Score: 168.318 bits (425), Expect = 3.141e-50
Identity = 95/287 (33.10%), Postives = 162/287 (56.45%), Query Frame = 2 
Query:  113 TEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKS---NLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLS--NYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            +  +A + +L + +N     T++E    L   ++ L  +D ++  + S  ELF+RFIT   LD + DFK     L+++  LF+ +   +  +IA+LS++++K  +++L H  S+ V E L   +    +K+ ++++    P ++  L    L      S V +D  ++ + +E++D V  GAE VV SGGIIN+IGT  IA++ +  + PFYVV E F+F RL+PL+Q+D+P   +YK              P ++Y  P YI+++ TD+G + P  VS+EL KLYL
Sbjct:   21 SAAVAAIHTLIEFMNTSQAETLSELRDNLQKVIESLTRADVAVTSVSSGCELFLRFITLSALD-SPDFKECKRVLVERGQLFLKRAASARQKIARLSDAFVKDGATILTHSRSRVVLEIL--KMAAEQKKRFDVFITESAPDQSGHLMHAQLKECGIPSTVILDS-AVGYVIEKVDLVLVGAEGVVESGGIINKIGTYQIAVMTKNANKPFYVVAESFKFVRLYPLNQEDVPNSSKYKRGTSNGTGH-----PVVDYTPPSYITLLFTDLGVLTPSAVSDELIKLYL 298
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Nematostella
Match: EDO41375 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4E3])

HSP 1 Score: 55.4546 bits (132), Expect = 6.412e-9
Identity = 35/130 (26.92%), Postives = 67/130 (51.54%), Query Frame = 2 
Query:  593 SISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFT-----------------RLFPL---SQQDIPTEFRYKASVRAQN--KDLTAVMPDLEYVRPEYISMIITDIGCIP 916
            +IS+ ++++  VF GA A++ +G + + +G+  IA++A  ++VP  V  E ++F+                  L P+   S++D   E+R   S+   N   D+T          P++ISM++T++G IP
Sbjct:  131 AISYVIKEVSKVFLGAHALLANGYVKSRVGSSMIAMMANAYNVPVLVCCETYKFSDRVQTDSFVSNELGDPDDLVPISLYSERDTLAEWRDTPSLHLLNLVYDVTP---------PDFISMVVTEVGMIP 251
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Nematostella
Match: EDO32884 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STS2])

HSP 1 Score: 54.299 bits (129), Expect = 2.349e-8
Identity = 35/130 (26.92%), Postives = 67/130 (51.54%), Query Frame = 2 
Query:  593 SISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFT-----------------RLFPL---SQQDIPTEFRYKASVRAQN--KDLTAVMPDLEYVRPEYISMIITDIGCIP 916
            +IS+ ++++  VF GA A++ +G + + +G+  IA++A  ++VP  V  E ++F+                  L P+   S++D   E+R   S+   N   D+T          P++ISM++T++G IP
Sbjct:  262 AISYVIKEVSKVFLGAHALLANGYVKSRVGSSMIAMMANAYNVPVLVCCETYKFSDRVQTDSFVSNELGDPDDLVPISRHSERDTLAEWRDTPSLHLLNLVYDVTP---------PDFISMVVTEVGMIP 382
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Medaka
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:101161422])

HSP 1 Score: 176.407 bits (446), Expect = 6.979e-53
Identity = 101/302 (33.44%), Postives = 170/302 (56.29%), Query Frame = 2 
Query:   77 DKFNEYFN-----DEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSN-YVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            ++  EYF      D      +A +++L + +   +  TI      L  A D L   D S+A + S  ELF+RFI+   L++      K  + ++ +LF+ KI+ S +++AKL ++++K  + +L H  S+ V   L        +K+ ++YV    P    +     L+  +V +  +   ++ + LE++D V  GAE VV SGGIIN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P +F+YKA    + ++L+   P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    4 EELVEYFRAQMRTDPDMASAVAAIRTLLEFLRRDTGETILGLRESLTWATDCLKGEDSSVA-VSSGGELFLRFISLTSLEHQDLSRCKKVMEERGELFLEKISMSRNKVAKLCHTFIKDGAKILTHSFSRVVLRVL--EKAAMEKKRFSVYVTESQPDAAGQQMAAELAKLHVPVTVVLDAAVGYVLEKVDLVIVGAEGVVESGGIINKIGTYQMALCSKAHNKPFYVVAESFKFVRLYPLNQQDVPDKFKYKADTLKKRQNLSEEHPVIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 302
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Medaka
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:101161422])

HSP 1 Score: 170.629 bits (431), Expect = 6.458e-51
Identity = 98/282 (34.75%), Postives = 163/282 (57.80%), Query Frame = 2 
Query:  134 KSLRDLINE----CSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVI-GLPIENYKLKIRNLSN-YVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            K+L  +++E     +  TI      L  A D L   D S+A + S  ELF+RFI+   L++      K  + ++ +LF+ KI+ S +++AKL ++++K  + +L H  S+ V   L        +K+ ++YV    P    +     L+  +V +  +   ++ + LE++D V  GAE VV SGGIIN+IGT  +A+ ++ H+ PFYVV E F+F RL+PL+QQD+P +F+YKA    + ++L+   P ++Y  P  I+++ TD+G + P  VS+EL KLYL
Sbjct:    4 KTLSSMVDEKRLAPAGETILGLRESLTWATDCLKGEDSSVA-VSSGGELFLRFISLTSLEHQDLSRCKKVMEERGELFLEKISMSRNKVAKLCHTFIKDGAKILTHSFSRVVLRVL--EKAAMEKKRFSVYVTESQPDAAGQQMAAELAKLHVPVTVVLDAAVGYVLEKVDLVIVGAEGVVESGGIINKIGTYQMALCSKAHNKPFYVVAESFKFVRLYPLNQQDVPDKFKYKADTLKKRQNLSEEHPVIDYTPPSLITLLFTDLGVLTPSAVSDELIKLYL 282
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Medaka
Match: eif2b1 (eukaryotic translation initiation factor 2B subunit alpha [Source:NCBI gene;Acc:101161422])

HSP 1 Score: 57.3806 bits (137), Expect = 1.868e-9
Identity = 38/140 (27.14%), Postives = 71/140 (50.71%), Query Frame = 2 
Query:   98 NDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYT--CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYV 511
             D      +A +++L + +   +  TI      L  A D L   D S+A + S  ELF+RFI+   L++      K  + ++ +LF+ KI+ S +++AKL ++++K  + +L H  S+ V   L        +K+ ++YV
Sbjct:    3 TDPDMASAVAAIRTLLEFLRRDTGETILGLRESLTWATDCLKGEDSSVA-VSSGGELFLRFISLTSLEHQDLSRCKKVMEERGELFLEKISMSRNKVAKLCHTFIKDGAKILTHSFSRVVLRVLEKAAME--KKRFSVYV 139
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Medaka
Match: eif2b2 (eukaryotic translation initiation factor 2B subunit beta [Source:NCBI gene;Acc:101167261])

HSP 1 Score: 58.5362 bits (140), Expect = 2.428e-9
Identity = 51/223 (22.87%), Postives = 108/223 (48.43%), Query Frame = 2 
Query:  308 CDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIG--LPI-ENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVR--AQNKDLTAV---MPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLY 952
               ++N+I+  +  + ++  + D IA  +  ++ S   ++  G S+TV EA    +KN +RK+    ++    P  + +++     ++ +    I   +I   + +++ V  G + V+ +GG+    GT  +A+ A+ H  P  V   +F+ +  FP +++D   +F     V    + + L+ V    P  +YV PE I++ I++IG   P  +   + +LY
Sbjct:  131 ASLRANVIEAINELLTELEGTTDNIAMQALEHIHSNEVIMTIGRSRTV-EAF---LKNAARKRKFHVIVAECAPFCQGHEMATHLSTDGIETTVIPDAAIFAVMSRVNKVIIGTQTVLANGGLRAVNGTHTLALAAKHHSTPLIVCAPMFKLSPQFP-NEEDTFHKFVSPHEVLPFTEGEILSKVNVHCPVFDYVPPELITLFISNIGGHAPSYIYRLMSELY 348
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Medaka
Match: eif2b4 (eukaryotic translation initiation factor 2B subunit delta [Source:NCBI gene;Acc:101162495])

HSP 1 Score: 53.9138 bits (128), Expect = 1.042e-7
Identity = 66/271 (24.35%), Postives = 124/271 (45.76%), Query Frame = 2 
Query:  143 RDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFIA-KITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLP-IENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRF-----TRLFPLSQQDIPTEF----RYKASVRAQNKDLTAVMPDLEY--VRPEYISMIITDIGCIP 916
            RDL+N+     +  Y S LN    + A+   ++  I+          + CK +   + K+ L+   + +I  KI  +   IA  S   +     +LV+G S  V   L     +  RK   I V   P +E  +   R +   +S   +   ++S+ L ++  VF GA A++ +G +++ +GT  IA++A+  +VP  V  E ++F     T  F  ++ D P +     + K  +    +  +  + +L Y    P+++ ++ITD+G IP
Sbjct:  259 RDLVNK-----LKPYISFLNQCRPLSASMGNAIKYIKKE---ISNIPSQCKEE---EAKNKLLTSIEWYIKEKIILAATAIAHSSIEKISDGDVILVYGCSSLVNHILCEAY-DKQRKFRVIVVDSRPRLEGREALRRLVQKGISCTYVLISAVSYILPEVSKVFLGAHALLANGYVMSRVGTSQIALVAKAFNVPVLVCCETYKFCERVQTDSFVSNELDDPDDLIVTRKGKTQLAGWQQVASLGLLNLVYDVTPPDFVDLVITDLGMIP 517
[Close]
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Planmine SMEST
Match: SMESG000039439.1 (SMESG000039439.1)

HSP 1 Score: 607.831 bits (1566), Expect = 0.000e+0
Identity = 297/300 (99.00%), Postives = 298/300 (99.33%), Query Frame = 2 
Query:   56 MSSFKISDKFNEYFNDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 955
            MS FKISDKFNEYFNDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALF HVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRA+NKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL
Sbjct:    1 MSFFKISDKFNEYFNDEKCTEGLATVKSLRDLINECSTSTITEYDSILNNAVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFIAKITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFQHVKNNSRKKLNIYVIGLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVGSGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRYKASVRAKNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL 300
The following BLAST results are available for this feature:
BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
EIF2B11.807e-5234.77eukaryotic translation initiation factor 2B subuni... [more]
EIF2B14.249e-1228.86eukaryotic translation initiation factor 2B subuni... [more]
EIF2B14.500e-1128.37eukaryotic translation initiation factor 2B subuni... [more]
EIF2B11.361e-829.46eukaryotic translation initiation factor 2B subuni... [more]
EIF2B49.060e-823.98eukaryotic translation initiation factor 2B subuni... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
eif-2Balpha7.354e-5336.73Probable translation initiation factor eIF-2B subu... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
eIF2Balpha7.001e-4732.99gene:FBgn0039726 transcript:FBtr0085508[more]
CG113344.387e-627.12gene:FBgn0039849 transcript:FBtr0085808[more]
CG113344.387e-627.12gene:FBgn0039849 transcript:FBtr0085809[more]
CG113344.387e-627.12gene:FBgn0039849 transcript:FBtr0334556[more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
eif2b11.673e-5736.33eukaryotic translation initiation factor 2B, subun... [more]
eif2b11.673e-5736.33eukaryotic translation initiation factor 2B, subun... [more]
eif2b14.356e-5735.81eukaryotic translation initiation factor 2B, subun... [more]
eif2b22.827e-723.32eukaryotic translation initiation factor 2B, subun... [more]
eif2b22.827e-723.32eukaryotic translation initiation factor 2B, subun... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
eif2b11.849e-4934.77eukaryotic translation initiation factor 2B subuni... [more]
eif2b12.507e-4935.56eukaryotic translation initiation factor 2B subuni... [more]
eif2b14.662e-4935.17eukaryotic translation initiation factor 2B subuni... [more]
eif2b12.049e-3033.05eukaryotic translation initiation factor 2B subuni... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Eif2b11.669e-5134.65eukaryotic translation initiation factor 2B, subun... [more]
Eif2b14.404e-1128.19eukaryotic translation initiation factor 2B, subun... [more]
Eif2b49.050e-825.83eukaryotic translation initiation factor 2B, subun... [more]
Eif2b11.020e-728.69eukaryotic translation initiation factor 2B, subun... [more]
Eif2b41.233e-722.22eukaryotic translation initiation factor 2B, subun... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5RAR0|EI2BA_PONAB8.679e-5234.77Translation initiation factor eIF-2B subunit alpha... [more]
sp|Q14232|EI2BA_HUMAN8.679e-5234.77Translation initiation factor eIF-2B subunit alpha... [more]
sp|P34604|EI2BA_CAEEL9.354e-5236.73Probable translation initiation factor eIF-2B subu... [more]
sp|Q64270|EI2BA_RAT2.065e-5134.92Translation initiation factor eIF-2B subunit alpha... [more]
sp|Q4R4V8|EI2BA_MACFA3.840e-5134.44Translation initiation factor eIF-2B subunit alpha... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A067R0C82.208e-6036.77Translation initiation factor eIF-2B subunit alpha... [more]
A0A2J7Q3Q74.490e-6037.25Translation initiation factor eIF-2B subunit alpha... [more]
A0A1B6CXV94.631e-5735.62Uncharacterized protein OS=Clastoptera arizonana O... [more]
A0A0N7Z9A65.441e-5637.33Putative translation initiation factor eif-2b subu... [more]
R4G4Q45.441e-5637.33Putative eukaryotic translation initiation factor ... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
eif2b14.137e-5535.53eukaryotic translation initiation factor 2B subuni... [more]
eif2b11.377e-5435.67eukaryotic translation initiation factor 2B subuni... [more]
eif2b11.377e-5435.67eukaryotic translation initiation factor 2B subuni... [more]
eif2b11.377e-5435.67eukaryotic translation initiation factor 2B subuni... [more]
eif2b49.849e-924.64eukaryotic translation initiation factor 2B, subun... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
eif2b15.795e-5434.25eukaryotic translation initiation factor 2B, subun... [more]
eif2b44.868e-1020.13eukaryotic translation initiation factor 2B, subun... [more]
eif2b21.243e-622.07eukaryotic translation initiation factor 2B, subun... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
GCN31.628e-3829.84Alpha subunit of translation initiation factor eIF... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO350873.141e-5033.10Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413756.412e-926.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO328842.349e-826.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
eif2b16.979e-5333.44eukaryotic translation initiation factor 2B subuni... [more]
eif2b16.458e-5134.75eukaryotic translation initiation factor 2B subuni... [more]
eif2b11.868e-927.14eukaryotic translation initiation factor 2B subuni... [more]
eif2b22.428e-922.87eukaryotic translation initiation factor 2B subuni... [more]
eif2b41.042e-724.35eukaryotic translation initiation factor 2B subuni... [more]
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BLAST of Translation initiation factor eIF-2B subunit alpha vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000039439.10.000e+099.00SMESG000039439.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028259 ID=SMED30028259|Name=Translation initiation factor eIF-2B subunit alpha|organism=Schmidtea mediterranea sexual|type=transcript|length=967bp
CTTTTTGTTTAAATAATGCTAAATTAATCATTTATTCTATCTAACTTATT
TTTTCATGAGTTCTTTTAAAATTAGTGACAAATTCAACGAATATTTTAAT
GATGAAAAATGCACCGAAGGTTTAGCAACTGTTAAATCTTTGCGAGATTT
AATCAACGAATGTTCTACTTCAACTATAACTGAATATGATTCAATTTTAA
ATAATGCAGTTGATATTTTAGCAAATTCTGATTATTCTTTGGCTCCAATT
CGATCTGCTGCTGAATTATTTATGAGATTTATTACATTTTGTAAATTAGA
TTATACATGTGATTTTAAATCCAACTTAATAAAAAAAGCCGATTTGTTTA
TTGCAAAAATAACCAAAAGCATTGACGAAATTGCTAAATTGTCCAATAGT
TATTTGAAAAGTTGCTCAAGCGTTTTAGTGCACGGAGGATCGAAAACTGT
GTGGGAAGCATTATTTCACCACGTTAAAAATAATAGTAGAAAAAAATTAA
ATATTTATGTTATTGGGCTTCCTATAGAAAATTATAAATTAAAAATTCGC
AATTTATCAAACTATGTGTCAATAGTGGAAATTGACAAAATATCCATTTC
TCATTATTTGGAACAAATTGATGCGGTTTTCTTTGGTGCTGAAGCCGTAG
TCGGGAGTGGAGGAATAATCAATGAAATCGGTACAAAAGATATTGCTATA
TTGGCTCAAACTCATCACGTTCCATTTTATGTCGTCACTGAAATATTTCG
ATTCACTCGACTGTTTCCTTTGTCGCAGCAAGACATTCCCACCGAATTCC
GATACAAAGCCAGCGTCCGGGCGCAGAATAAGGACCTGACAGCCGTGATG
CCGGATTTGGAATACGTGCGACCGGAATATATCAGCATGATTATCACCGA
TATCGGCTGCATCCCACCTTGCAATGTCAGTGAAGAGCTTTTTAAACTTT
ATTTGTAGATTTTAATA
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protein sequence of SMED30028259-orf-1

>SMED30028259-orf-1 ID=SMED30028259-orf-1|Name=SMED30028259-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=301bp
MSSFKISDKFNEYFNDEKCTEGLATVKSLRDLINECSTSTITEYDSILNN
AVDILANSDYSLAPIRSAAELFMRFITFCKLDYTCDFKSNLIKKADLFIA
KITKSIDEIAKLSNSYLKSCSSVLVHGGSKTVWEALFHHVKNNSRKKLNI
YVIGLPIENYKLKIRNLSNYVSIVEIDKISISHYLEQIDAVFFGAEAVVG
SGGIINEIGTKDIAILAQTHHVPFYVVTEIFRFTRLFPLSQQDIPTEFRY
KASVRAQNKDLTAVMPDLEYVRPEYISMIITDIGCIPPCNVSEELFKLYL
*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR042528elF-2B_alpha_N
IPR042529IF_2B-like_C
IPR037171NagB/RpiA_transferase-like
IPR000649IF-2B-related
Vocabulary: biological process
TermDefinition
GO:0044237cellular metabolic process
GO:0006413translational initiation
Vocabulary: molecular function
TermDefinition
GO:0003743translation initiation factor activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR042528Translation initiation factor eIF-2B subunit alpha, N-terminalGENE3DG3DSA:1.20.120.1070coord: 4..102
e-value: 9.2E-15
score: 56.7
IPR000649Initiation factor 2B-relatedPFAMPF01008IF-2Bcoord: 22..288
e-value: 7.3E-41
score: 140.2
IPR042529Initiation factor 2B-like, C-terminalGENE3DG3DSA:3.40.50.10470coord: 104..300
e-value: 2.5E-44
score: 152.8
NoneNo IPR availablePANTHERPTHR45860:SF1TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHAcoord: 4..299
NoneNo IPR availablePANTHERPTHR45860FAMILY NOT NAMEDcoord: 4..299
IPR037171NagB/RpiA transferase-likeSUPERFAMILYSSF100950NagB/RpiA/CoA transferase-likecoord: 19..299