DNA topoisomerase 2 binding protein 1
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028218 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Human
Match: TOPBP1 (DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008]) HSP 1 Score: 150.214 bits (378), Expect = 1.023e-35 Identity = 97/392 (24.74%), Postives = 185/392 (47.19%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVP----GSTPKK--------------DSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYRP 1283
+++ F +L+ L I GPQ ++ +P++ +P++++ + D+ + +S+E+E + ++ V+MM G V L +V LI+ V S+KY VA+ P++ W++ LW S+ ++ I ++ ++ PI IC++G +R E +Q+ +++GG + L +N+CTHLI + GQK+ AK+WN+ VT +W +SI+KG+ D Y+ STP ++ + +S CN ++ + + + L+N D S + C L + + K LI GG + + TH+IV D+ + K+ + + + WL C ++ +++ YI Y+P
Sbjct: 57 LYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQE-KKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDNVSNISNINASCVSESICNSLNSKLEPTLEN---LENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQP 444 HSP 2 Score: 102.834 bits (255), Expect = 3.276e-21 Identity = 120/462 (25.97%), Postives = 205/462 (44.37%), Query Frame = 3
Query: 1428 GIFYKFIFHMDNETCEKSIRIVNSITENAGTVIST-TEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQ-SDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCD----QSKS-------SIKNQCSTPVRNKALDIDWK-HSDMESPIYREDP-NKPRPKLIYDENMFKTPEQ-WKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
G+F + F + + E I N I ENAG ++S + Y + + +++ + VVT ++ C++ + S+ LF P+ + + T L VISFS E++ L LGA+VQ+ RK K + A+THLI+ + K+ ++K W +PAVT W+ E KR D ++L++ S S+ T ++ N N + +HP G + ++ + VT D QSK+ + ++P + L + H D S +D KP + +TP + ++ RKP +P++ ++N L +A + + L E S+ + APKPL VV+ + + +L I +LG W++D +TVT + +D NR E E +V+ WLL C +E +H+ E Y
Sbjct: 546 GLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEA--TVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGM--TPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNS--DTAEHP--GTRLQTHRKTV-----VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKN-LQLALANSSRNAVALSASPQLKEAQSEKEE--APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFD-ETVTHFI-----YQGRPNDTNR-EYKSVKERGVHIVSEHWLLDCAQECKHLPESLY 984 HSP 3 Score: 85.8853 bits (211), Expect = 4.017e-16 Identity = 52/167 (31.14%), Postives = 83/167 (49.70%), Query Frame = 3
Query: 2994 QLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE---------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVP 3467
+L + +F S++ Y I LGG + F TH++ G P NEKYLA++AAGKWVLH+SYL+ + G +++E +++WG S L + + LAL A+ W + I GAF W+V L + +++++GG V+P
Sbjct: 1258 ELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSS---SILDVLTGINVQQRRLAL--AAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLP 1419
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Human
Match: TOPBP1 (DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008]) HSP 1 Score: 149.058 bits (375), Expect = 1.959e-35 Identity = 100/397 (25.19%), Postives = 186/397 (46.85%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVP----GSTPKK-----DSKIIMD--------------SKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYRP 1283
+++ F +L+ L I GPQ ++ +P++ +P++++ + D+ + +S+E+E + ++ V+MM G V L +V LI+ V S+KY VA+ P++ W++ LW S+ ++ I ++ ++ PI IC++G +R E +Q+ +++GG + L +N+CTHLI + GQK+ AK+WN+ VT +W +SI+KG+ D Y+ STP DS+ + D S CN ++ + + + L+N D S + C L + + K LI GG + + TH+IV D+ + K+ + + + WL C ++ +++ YI Y+P
Sbjct: 57 LYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQE-KKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLEN---LENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQP 449 HSP 2 Score: 102.449 bits (254), Expect = 3.953e-21 Identity = 120/462 (25.97%), Postives = 205/462 (44.37%), Query Frame = 3
Query: 1428 GIFYKFIFHMDNETCEKSIRIVNSITENAGTVIST-TEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQ-SDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCD----QSKS-------SIKNQCSTPVRNKALDIDWK-HSDMESPIYREDP-NKPRPKLIYDENMFKTPEQ-WKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
G+F + F + + E I N I ENAG ++S + Y + + +++ + VVT ++ C++ + S+ LF P+ + + T L VISFS E++ L LGA+VQ+ RK K + A+THLI+ + K+ ++K W +PAVT W+ E KR D ++L++ S S+ T ++ N N + +HP G + ++ + VT D QSK+ + ++P + L + H D S +D KP + +TP + ++ RKP +P++ ++N L +A + + L E S+ + APKPL VV+ + + +L I +LG W++D +TVT + +D NR E E +V+ WLL C +E +H+ E Y
Sbjct: 551 GLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEA--TVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGM--TPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNS--DTAEHP--GTRLQTHRKTV-----VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKN-LQLALANSSRNAVALSASPQLKEAQSEKEE--APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFD-ETVTHFI-----YQGRPNDTNR-EYKSVKERGVHIVSEHWLLDCAQECKHLPESLY 989 HSP 3 Score: 85.8853 bits (211), Expect = 4.022e-16 Identity = 52/167 (31.14%), Postives = 83/167 (49.70%), Query Frame = 3
Query: 2994 QLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE---------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVP 3467
+L + +F S++ Y I LGG + F TH++ G P NEKYLA++AAGKWVLH+SYL+ + G +++E +++WG S L + + LAL A+ W + I GAF W+V L + +++++GG V+P
Sbjct: 1263 ELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSS---SILDVLTGINVQQRRLAL--AAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLP 1424
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Human
Match: SLF1 (SMC5-SMC6 complex localization factor 1 [Source:HGNC Symbol;Acc:HGNC:25408]) HSP 1 Score: 84.3445 bits (207), Expect = 1.187e-15 Identity = 57/176 (32.39%), Postives = 88/176 (50.00%), Query Frame = 3
Query: 3120 THLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE----IGG-GAFKEWRVCLIEKNEKY-EKMCKIIEAGGGTVV-PFSEPISQLGVTHFLVNKSQCSGLPDLSQY--PCYKIEMIPSFL---SAQNDRE 3611
THLI C +EK+LAA AAGKW+L K Y+ S G+WL+ET ++WG ++ Y + A K W E G GAF W+V L+ + +K + + +++EAG V+ P S P G+TH + + ++ + + P Y I+ + FL QND +
Sbjct: 44 THLIAERLCKSEKFLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWG-------YKIEKDSRYSP---QMQSAPKRWREELKRTGAPGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPS---GITHVIASNARIKAEKEKDNFKAPFYPIQYLGDFLLEKEIQNDED 206
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Human
Match: ECT2 (epithelial cell transforming 2 [Source:HGNC Symbol;Acc:HGNC:3155]) HSP 1 Score: 80.8777 bits (198), Expect = 1.072e-14 Identity = 52/218 (23.85%), Postives = 99/218 (45.41%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSI-EEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FV+ F+ S L + GP +L K + LP S PL+ ++ ++ +CF+ ++E + L V M G + + V L+++ Q K+RVA G P+++ EW+ + W +N +++++P + + GF++ E+ ++M GG + P L CTHL+ + + + + V EW SI+
Sbjct: 95 VFVVTDFQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWE-RRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNMEEMTEMQGGKYLP-LGDERCTHLVVEENIVKDLPFEPSKKLYVVKQEWFWGSIQ 310
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Human
Match: ECT2 (epithelial cell transforming 2 [Source:HGNC Symbol;Acc:HGNC:3155]) HSP 1 Score: 80.8777 bits (198), Expect = 1.073e-14 Identity = 52/218 (23.85%), Postives = 99/218 (45.41%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSI-EEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FV+ F+ S L + GP +L K + LP S PL+ ++ ++ +CF+ ++E + L V M G + + V L+++ Q K+RVA G P+++ EW+ + W +N +++++P + + GF++ E+ ++M GG + P L CTHL+ + + + + V EW SI+
Sbjct: 96 VFVVTDFQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWE-RRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNMEEMTEMQGGKYLP-LGDERCTHLVVEENIVKDLPFEPSKKLYVVKQEWFWGSIQ 311
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Celegans
Match: mus-101 (pep chromosome:WBcel235:I:10479283:10484969:-1 gene:WBGene00009507.1 transcript:F37D6.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mus-101) HSP 1 Score: 110.153 bits (274), Expect = 6.118e-24 Identity = 61/252 (24.21%), Postives = 130/252 (51.59%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSV-QSRKYRVASEKGIPVVRKEWVEELWTLSKNCV-QLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKW-NITTVTCEWLIESIKKGYACDVDQYQ---LSDEIHVPGSTPKKDSKI 914
FVL F + L++ KL ++GP +L LP+ +P++S +D+ + F+ + K +L K+ M G V DAL L++ Q+ KY+ A I ++R W+++LW S+ + + + + + ++ Y + + L++ ++ + ++R Q++ ++GG ++ C++LI+ +G K++ A +W ++ V W+ + + G+ D +Y L+ + H+ STPK+D+ +
Sbjct: 84 FFVLPCFRGKLFRKLQARKLKVYGPPIVLESIEDGKQLPQWNHPVYSSVFQDVKISFTGLNLTKKQELYEKIGWMCGVVGDALYHETTHLVTEKAEQTEKYKAAVNNSIKLMRIGWIDDLWETSQTTMGRFSALSRDSVNSYALRVFEGLEMAITSIDGADRTNFIQLIEDHGGKVPGTMSKTRCSYLISDKITGVKYAKAVEWKSMQIVQSRWIRKCVDLGHLVDAGKYHPKYLTAD-HIRSSTPKRDANV 334 HSP 2 Score: 72.4034 bits (176), Expect = 1.756e-12 Identity = 63/215 (29.30%), Postives = 94/215 (43.72%), Query Frame = 3
Query: 3024 SNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQW------GGSRKNEFLQLNPTKTYGKIFLAL------------LDASKHWHEIGGGAFKEWRVCLIEKNEKYEKM-CKIIEAGGGTVVPFSE--PISQLGVTHFLVNK-----SQCSGLPDLSQYPCYKIEMIPSFL 3590
SN+ E I LGG++E +F+ +THLI K L +IAAGKW L Y+ +S G+WL+E F+W S+KNE L+ ++ + A+ + S GAF +WR C+I ++K + I+EAGG V SE +S L L +K Q + L P Y +++ FL
Sbjct: 952 SNMDPQRAADLQETIMKLGGTIE--REFNKDVTHLIASNMQRAPKVLCSIAAGKWCLTPDYVTKSAEVGRWLDEKSFEWTREKLLACSKKNESLKERDSRKVSENLAAVCGLWRQRVAEMPVTFSVSMENRQNGAFSDWR-CVIHLDDKRAGVFSSILEAGGAIVHSISEYVEVSTLKPNIVLASKEFPWNPQSAVLLKRDNIPIYVFDILYDFL 1163
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Celegans
Match: ect-2 (ECT2 (Mammalian Rho GEF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9U364]) HSP 1 Score: 67.781 bits (164), Expect = 4.673e-11 Identity = 54/219 (24.66%), Postives = 103/219 (47.03%), Query Frame = 3
Query: 213 KYLESLKLPIFGPQCLLAYFGKDDVLP--KSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL 863
K+ E+ L I G L K++ L ++ PL+ +KD+ + ++ E NK +L + V M G V + + I++ V++ K + S G+P +R +WV E W ++ + +E +DK+++ + L + GF ++E D+ + + GG P+ + TH++ + + + A N VT EW S+ +G D + L
Sbjct: 80 KHQETQALFIIGASVLKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAA-EVPNKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEA-KVQSISLVGVPTMRADWVTECWK-HRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTL--ATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFAL 293
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Celegans
Match: ect-2 (ECT2 (Mammalian Rho GEF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9U364]) HSP 1 Score: 67.781 bits (164), Expect = 4.673e-11 Identity = 54/219 (24.66%), Postives = 103/219 (47.03%), Query Frame = 3
Query: 213 KYLESLKLPIFGPQCLLAYFGKDDVLP--KSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL 863
K+ E+ L I G L K++ L ++ PL+ +KD+ + ++ E NK +L + V M G V + + I++ V++ K + S G+P +R +WV E W ++ + +E +DK+++ + L + GF ++E D+ + + GG P+ + TH++ + + + A N VT EW S+ +G D + L
Sbjct: 80 KHQETQALFIIGASVLKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAA-EVPNKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEA-KVQSISLVGVPTMRADWVTECWK-HRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTL--ATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFAL 293
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Celegans
Match: ect-2 (ECT2 (Mammalian Rho GEF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9U364]) HSP 1 Score: 67.781 bits (164), Expect = 4.691e-11 Identity = 54/219 (24.66%), Postives = 103/219 (47.03%), Query Frame = 3
Query: 213 KYLESLKLPIFGPQCLLAYFGKDDVLP--KSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL 863
K+ E+ L I G L K++ L ++ PL+ +KD+ + ++ E NK +L + V M G V + + I++ V++ K + S G+P +R +WV E W ++ + +E +DK+++ + L + GF ++E D+ + + GG P+ + TH++ + + + A N VT EW S+ +G D + L
Sbjct: 80 KHQETQALFIIGASVLKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAA-EVPNKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEA-KVQSISLVGVPTMRADWVTECWK-HRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTL--ATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFAL 293
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Celegans
Match: ect-2 (ECT2 (Mammalian Rho GEF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9U364]) HSP 1 Score: 67.781 bits (164), Expect = 4.691e-11 Identity = 54/219 (24.66%), Postives = 103/219 (47.03%), Query Frame = 3
Query: 213 KYLESLKLPIFGPQCLLAYFGKDDVLP--KSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL 863
K+ E+ L I G L K++ L ++ PL+ +KD+ + ++ E NK +L + V M G V + + I++ V++ K + S G+P +R +WV E W ++ + +E +DK+++ + L + GF ++E D+ + + GG P+ + TH++ + + + A N VT EW S+ +G D + L
Sbjct: 80 KHQETQALFIIGASVLKNKLLKNEDLMTLRAARPLYCELMKDVTMKLAA-EVPNKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEA-KVQSISLVGVPTMRADWVTECWK-HRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTL--ATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFAL 293
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Fly
Match: mus101 (gene:FBgn0002878 transcript:FBtr0073817) HSP 1 Score: 112.464 bits (280), Expect = 1.523e-24 Identity = 68/267 (25.47%), Postives = 125/267 (46.82%), Query Frame = 3
Query: 159 NFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQI--LIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNL--NVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL--------SDEIHVPGSTPKKDSKIIMD 923
N K +FVL FE + L+ + I GP CL+ +++ +P+ ++S A++D+ V + I + K +L+ + M G + LIS++++S KY A+ G+PV+ +WV+ +W S+ Q G+ DKY++PI I SG + + +D+ ++V +NGG ++ V D +K+ A ++ + EW+ +S +GYA Y++ + PG+ P D + D
Sbjct: 67 NLTKKDVFVLTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYSTAMRDLQVSATGITPQKKEELSRLINWMGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVPVMHVDWVQYVWDQSRRS-QREGIMATDPDFDKYRLPIFFGANITCSGLDVARKDQVMRLVNDNGGIYHRAFRSQVVDIVITEQTKTDTEKYKAAIRYKKDVLLPEWIFDSCNRGYALPTKDYEVRPGKTSSTPTKTTRPGAAPGADQTHLSD 332 HSP 2 Score: 78.1814 bits (191), Expect = 4.067e-14 Identity = 49/155 (31.61%), Postives = 76/155 (49.03%), Query Frame = 3
Query: 3066 IRNLGGSLELN-SDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVV----PFSEPISQLGVTHFLVN 3515
I LGG + N ++ THL+C P EK LA IAAGKW+L+ Y+++S ++G +L+ET ++WG + L P + I A+ GGGAF + RV L + ++ AGG ++ PFS+ +H V+
Sbjct: 1228 ITQLGGKVCENLVNYDDSCTHLLCERPNRGEKMLACIAAGKWILNIQYIEQSHARGDFLDETLYEWGNPKAINLPTLAPEEE--PIAAAVHRWRTELSACGGGAFSDHRVILSMNERSGAPIRNVLRAGGACILEPTTPFSKDPVAKSASHCFVD 1380 HSP 3 Score: 52.373 bits (124), Expect = 3.936e-6 Identity = 34/146 (23.29%), Postives = 62/146 (42.47%), Query Frame = 3
Query: 1608 VVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSD 2045
VVT ++E C+++NQ+LP++ + + + L G I S Y ER + T LGA+V +K+ P L+ + K+ + W P VT W+ +C +++ YL+ + ++ D
Sbjct: 674 VVTELFLESCMKKNQLLPIE----YYHKHVPATALRQPLKGMTIVVSIYAGLERDFINATAELLGASVNKTFIKKEKP--------LLVCPSAEGSKYEGAIKWNYPVVTSDWLVQCARTGQKLPFVGYLVGKSPEDFPISPRLRD 807
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Fly
Match: pbl (gene:FBgn0003041 transcript:FBtr0076771) HSP 1 Score: 84.7297 bits (208), Expect = 3.400e-16 Identity = 58/246 (23.58%), Postives = 109/246 (44.31%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSK 911
+VL FE +S + + K I GP L L ++ P+++ A++ + CF+ I +++++ L N + M G + L LI + KY+ A + VVR WV W +N ++ + ++ +++ KIC GF E +++ENGG L+ +C+H++ + K + + +W +I+ GYA ++D Y D + +TP D +
Sbjct: 65 FYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWA-DRNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGG-VCAELDDPECSHVVVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMD-YLFGDYLDSITNTPNTDRR 307
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Fly
Match: pbl (gene:FBgn0003041 transcript:FBtr0112817) HSP 1 Score: 84.7297 bits (208), Expect = 3.943e-16 Identity = 58/246 (23.58%), Postives = 109/246 (44.31%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSK 911
+VL FE +S + + K I GP L L ++ P+++ A++ + CF+ I +++++ L N + M G + L LI + KY+ A + VVR WV W +N ++ + ++ +++ KIC GF E +++ENGG L+ +C+H++ + K + + +W +I+ GYA ++D Y D + +TP D +
Sbjct: 112 FYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWA-DRNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGG-VCAELDDPECSHVVVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMD-YLFGDYLDSITNTPNTDRR 354
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Fly
Match: pbl (gene:FBgn0003041 transcript:FBtr0076773) HSP 1 Score: 77.7962 bits (190), Expect = 4.273e-14 Identity = 52/225 (23.11%), Postives = 99/225 (44.00%), Query Frame = 3
Query: 240 IFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSK 911
I GP L L ++ P+++ A++ + CF+ I +++++ L N + M G + L LI + KY+ A + VVR WV W +N ++ + ++ +++ KIC GF E +++ENGG L+ +C+H++ + K + + +W +I+ GYA ++D Y D + +TP D +
Sbjct: 15 ILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWA-DRNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGG-VCAELDDPECSHVVVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMD-YLFGDYLDSITNTPNTDRR 236
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Fly
Match: pbl (gene:FBgn0003041 transcript:FBtr0076772) HSP 1 Score: 73.9442 bits (180), Expect = 8.274e-13 Identity = 47/194 (24.23%), Postives = 87/194 (44.85%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASG 755
+VL FE +S + + K I GP L L ++ P+++ A++ + CF+ I +++++ L N + M G + L LI + KY+ A + VVR WV W +N ++ + ++ +++ KIC GF E +++ENGG L+ +C+H++ N
Sbjct: 65 FYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWA-DRNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGG-VCAELDDPECSHVVMPNTGA 256
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Zebrafish
Match: topbp1 (DNA topoisomerase II binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-060626-1]) HSP 1 Score: 238.424 bits (607), Expect = 2.643e-63 Identity = 229/1019 (22.47%), Postives = 425/1019 (41.71%), Query Frame = 3
Query: 33 SFTVYFVQDT--TTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLS--------DEIHVPG-STPKKDSKIIMDS--------------KCNEISVIFDG-SHAD-ETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTK-----LTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSD------------------------NWGSMNELD-----WGDTMKTVEVNNNKD--------ESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTV-ISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLL-------QSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQS-------KSSIKN---------QCSTPVRNKALDIDWKHSDMESPIYREDPNK--PRPKL---------IYDENMFKTP----EQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
++ V FV+ +D+ QA+ +I + K + + +++ + +FV F S+ + L I P +L K +PK+ P++++++ D+ V +++++E + ++ + +++M G V L +V L++ V S+KY VA+ G P++ WV+ W S++ V + ++ + Y+ P+L +C++G + ER E +++ +NG ++ L +N+CTHLI +GQK+ +A+KWN+ V+ WL +SI+KG+ D +Y + D+ P STP S+ D NE ++ G SH + +D+ D + C D + C L + + K ++ GG + T THI++ + + L T + WL + L+ + Y + P A D S E D G+ VE+ + E V K + +A G+F+ F + E ++ + ENAG + + + HY + + ++ ++ V T ++ C+EQ +LPL S LF P+++ + L V+S S + ER L + LGA+VQD R K +LA+THL++ P+ K+ +++ WG+PAVT W+ E KR D G YL+ +++DS + + ++ PE L + S +T D + +S+++ + +TP + +A K +S ++ + P++ R KL ++D +TP +Q + P+S + ++ +A + + L + + A PL+GVV+ + + +L + +LG W+ D + + NS E E +V+ WL AC EQ+HV E Y
Sbjct: 8 AYIVKFVESNGQKSDVALQAYKAIVELQSEKYVQMVDEEAALELDHNDKSLFVFSDFTSSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNLDKEARSEVMDLIQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWEKSQDSVFHHS--ELNTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPTGQKYEFARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRSKEDGPSLLGLSHISNISLNVNETALTTAGISHIEMPDPVDSFDITVCRVDD-LLDGCKLYLCGLSGKKLEKLRRMVNTAGGLRFNQPTQELTHIVMGEADQGIKAFLDNATHRPHIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPALHKAAPRASRPSVAPPPAPSPARQSRAEEDLLSQYMGNDQTVVELPQDTSSRHSVLHPEPLVEGKDSTLAEASEGGLFFGKRFILVGFGAEAEAQLSELVMENAGKILVGRSRAVAHYAIVPLLGCDVE--ATVDEVATDTWLAMCVEQQCVLPLASHPLFTPVAVREGF--SPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQRKGMLASTHLVLQTPEGTKYQAAQKWGLPAVTIRWVLESARTGKRADEGQYLVDLPPSPERTEDSFVGASQKDPPPLRLHQ-----------RSPELPLLGPQNSDAITPLDTARFQSRSVRSAVRKLKQGEEEQAEVTTPGQEEAKGAQQK----DSSLHLDTPSRFLSRDKLFGPSFNTKDVFDH--LQTPGNKSQQGQGAETPLSEVIERNLKAAVANSNRSHVTNLAAMTASPQLGKEPEPEVEQKAAAPLSGVVVCVSKKLSKKQSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNS-------KEYRAVKERGLYIVSQHWLQACADEQKHVSESLY 995 HSP 2 Score: 95.1301 bits (235), Expect = 4.516e-19 Identity = 58/176 (32.95%), Postives = 90/176 (51.14%), Query Frame = 3
Query: 3015 FMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE-IGG-----GAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQ 3524
F+ S++ Y I LGG + F TH+I G P NEKYLAA+AAGKW+LH+SYL+ ++G +++E +++WG S L+ P+ + LAL A+ W + + G GAF W V L + +++++GG V+P P TH V+ S+
Sbjct: 1273 FLLSSLNPQERIDYSHLIEELGGVVLEKQSFDPSCTHVIVGHPLRNEKYLAAMAAGKWILHRSYLEACRAEGHFIQEDQYEWGSS---SILEALPSINSQQKRLAL--AAMRWRKTLQGCSNKEGAFGGWIVMLNIDQAREAGFRRLLQSGGAKVLPDPSPSLFKETTHLFVDFSR 1443
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Zebrafish
Match: topbp1 (DNA topoisomerase II binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-060626-1]) HSP 1 Score: 238.424 bits (607), Expect = 2.643e-63 Identity = 229/1019 (22.47%), Postives = 425/1019 (41.71%), Query Frame = 3
Query: 33 SFTVYFVQDT--TTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLS--------DEIHVPG-STPKKDSKIIMDS--------------KCNEISVIFDG-SHAD-ETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTK-----LTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSD------------------------NWGSMNELD-----WGDTMKTVEVNNNKD--------ESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTV-ISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLL-------QSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQS-------KSSIKN---------QCSTPVRNKALDIDWKHSDMESPIYREDPNK--PRPKL---------IYDENMFKTP----EQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
++ V FV+ +D+ QA+ +I + K + + +++ + +FV F S+ + L I P +L K +PK+ P++++++ D+ V +++++E + ++ + +++M G V L +V L++ V S+KY VA+ G P++ WV+ W S++ V + ++ + Y+ P+L +C++G + ER E +++ +NG ++ L +N+CTHLI +GQK+ +A+KWN+ V+ WL +SI+KG+ D +Y + D+ P STP S+ D NE ++ G SH + +D+ D + C D + C L + + K ++ GG + T THI++ + + L T + WL + L+ + Y + P A D S E D G+ VE+ + E V K + +A G+F+ F + E ++ + ENAG + + + HY + + ++ ++ V T ++ C+EQ +LPL S LF P+++ + L V+S S + ER L + LGA+VQD R K +LA+THL++ P+ K+ +++ WG+PAVT W+ E KR D G YL+ +++DS + + ++ PE L + S +T D + +S+++ + +TP + +A K +S ++ + P++ R KL ++D +TP +Q + P+S + ++ +A + + L + + A PL+GVV+ + + +L + +LG W+ D + + NS E E +V+ WL AC EQ+HV E Y
Sbjct: 8 AYIVKFVESNGQKSDVALQAYKAIVELQSEKYVQMVDEEAALELDHNDKSLFVFSDFTSSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNLDKEARSEVMDLIQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWEKSQDSVFHHS--ELNTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPTGQKYEFARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRSKEDGPSLLGLSHISNISLNVNETALTTAGISHIEMPDPVDSFDITVCRVDD-LLDGCKLYLCGLSGKKLEKLRRMVNTAGGLRFNQPTQELTHIVMGEADQGIKAFLDNATHRPHIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPALHKAAPRASRPSVAPPPAPSPARQSRAEEDLLSQYMGNDQTVVELPQDTSSRHSVLHPEPLVEGKDSTLAEASEGGLFFGKRFILVGFGAEAEAQLSELVMENAGKILVGRSRAVAHYAIVPLLGCDVE--ATVDEVATDTWLAMCVEQQCVLPLASHPLFTPVAVREGF--SPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQRKGMLASTHLVLQTPEGTKYQAAQKWGLPAVTIRWVLESARTGKRADEGQYLVDLPPSPERTEDSFVGASQKDPPPLRLHQ-----------RSPELPLLGPQNSDAITPLDTARFQSRSVRSAVRKLKQGEEEQAEVTTPGQEEAKGAQQK----DSSLHLDTPSRFLSRDKLFGPSFNTKDVFDH--LQTPGNKSQQGQGAETPLSEVIERNLKAAVANSNRSHVTNLAAMTASPQLGKEPEPEVEQKAAAPLSGVVVCVSKKLSKKQSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNS-------KEYRAVKERGLYIVSQHWLQACADEQKHVSESLY 995 HSP 2 Score: 95.1301 bits (235), Expect = 4.516e-19 Identity = 58/176 (32.95%), Postives = 90/176 (51.14%), Query Frame = 3
Query: 3015 FMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE-IGG-----GAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQ 3524
F+ S++ Y I LGG + F TH+I G P NEKYLAA+AAGKW+LH+SYL+ ++G +++E +++WG S L+ P+ + LAL A+ W + + G GAF W V L + +++++GG V+P P TH V+ S+
Sbjct: 1273 FLLSSLNPQERIDYSHLIEELGGVVLEKQSFDPSCTHVIVGHPLRNEKYLAAMAAGKWILHRSYLEACRAEGHFIQEDQYEWGSS---SILEALPSINSQQKRLAL--AAMRWRKTLQGCSNKEGAFGGWIVMLNIDQAREAGFRRLLQSGGAKVLPDPSPSLFKETTHLFVDFSR 1443
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Zebrafish
Match: topbp1 (DNA topoisomerase II binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-060626-1]) HSP 1 Score: 237.654 bits (605), Expect = 3.974e-63 Identity = 229/1018 (22.50%), Postives = 426/1018 (41.85%), Query Frame = 3
Query: 33 SFTVYFVQDT--TTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLS--------DEIHVPG-STPKKDSKIIMDS--------------KCNEISVIFDG-SHAD-ETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTK-----LTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSD------------------------NWGSMNELD----WGDTMKTVEVNNNKD--------ESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTV-ISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLL-------QSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQS-------KSSIKN---------QCSTPVRNKALDIDWKHSDMESPIYREDPNK--PRPKL---------IYDENMFKTP----EQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
++ V FV+ +D+ QA+ +I + K + + +++ + +FV F S+ + L I P +L K +PK+ P++++++ D+ V +++++E + ++ + +++M G V L +V L++ V S+KY VA+ G P++ WV+ W S++ V + ++ + Y+ P+L +C++G + ER E +++ +NG ++ L +N+CTHLI +GQK+ +A+KWN+ V+ WL +SI+KG+ D +Y + D+ P STP S+ D NE ++ G SH + +D+ D + C D + C L + + K ++ GG + T THI++ + + L T + WL + L+ + Y + P A D S E D + +TVE+ + E V K + +A G+F+ F + E ++ + ENAG + + + HY + + ++ ++ V T ++ C+EQ +LPL S LF P+++ + L V+S S + ER L + LGA+VQD R K +LA+THL++ P+ K+ +++ WG+PAVT W+ E KR D G YL+ +++DS + + ++ PE L + S +T D + +S+++ + +TP + +A K +S ++ + P++ R KL ++D +TP +Q + P+S + ++ +A + + L + + A PL+GVV+ + + +L + +LG W+ D + + NS E E +V+ WL AC EQ+HV E Y
Sbjct: 8 AYIVKFVESNGQKSDVALQAYKAIVELQSEKYVQMVDEEAALELDHNDKSLFVFSDFTSSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNLDKEARSEVMDLIQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWEKSQDSVFHHS--ELNTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPTGQKYEFARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRSKEDGPSLLGLSHISNISLNVNETALTTAGISHIEMPDPVDSFDITVCRVDD-LLDGCKLYLCGLSGKKLEKLRRMVNTAGGLRFNQPTQELTHIVMGEADQGIKAFLDNATHRPHIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPALHKAAPRASRPSVAPPPAPSPARQSRAEEDLLSQYMGNDQTVELPQDTSSRHSVLHPEPLVEGKDSTLAEASEGGLFFGKRFILVGFGAEAEAQLSELVMENAGKILVGRSRAVAHYAIVPLLGCDVE--ATVDEVATDTWLAMCVEQQCVLPLASHPLFTPVAVREGF--SPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQRKGMLASTHLVLQTPEGTKYQAAQKWGLPAVTIRWVLESARTGKRADEGQYLVDLPPSPERTEDSFVGASQKDPPPLRLHQ-----------RSPELPLLGPQNSDAITPLDTARFQSRSVRSAVRKLKQGEEEQAEVTTPGQEEAKGAQQK----DSSLHLDTPSRFLSRDKLFGPSFNTKDVFDH--LQTPGNKSQQGQGAETPLSEVIERNLKAAVANSNRSHVTNLAAMTASPQLGKEPEPEVEQKAAAPLSGVVVCVSKKLSKKQSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNS-------KEYRAVKERGLYIVSQHWLQACADEQKHVSESLY 994 HSP 2 Score: 93.2041 bits (230), Expect = 1.694e-18 Identity = 57/183 (31.15%), Postives = 89/183 (48.63%), Query Frame = 3
Query: 3015 FMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE-------------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQ 3524
F+ S++ Y I LGG + F TH+I G P NEKYLAA+AAGKW+LH+SYL+ ++G +++E +++WG S L+ P+ + LAL A+ W + + GAF W V L + +++++GG V+P P TH V+ S+
Sbjct: 1272 FLLSSLNPQERIDYSHLIEELGGVVLEKQSFDPSCTHVIVGHPLRNEKYLAAMAAGKWILHRSYLEACRAEGHFIQEDQYEWGSS---SILEALPSINSQQKRLAL--AAMRWRKTLQGCSNKEPNVIVVQGAFGGWIVMLNIDQAREAGFRRLLQSGGAKVLPDPSPSLFKETTHLFVDFSR 1449
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Zebrafish
Match: ect2 (epithelial cell transforming 2 [Source:ZFIN;Acc:ZDB-GENE-040831-2]) HSP 1 Score: 90.8929 bits (224), Expect = 5.663e-18 Identity = 54/219 (24.66%), Postives = 107/219 (48.86%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENK-IDLTNKVKMMHGFVS-DALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ +L I GP ++ K + LP S PL+S+ + ++ +CF+ ++++ + L N V M G + D A V LI+ S KYR+A G P++ +W+ + W ++ + + ++ ++++P + + GF+E E++ ++ ++GG F + CTHL+ + S ++ + + V EW SI+
Sbjct: 97 VFVLKDFQAPEYSFLYKNDSRILGPPAVMHCANKGEPLPFSSRPLYSMTMLNLSLCFTGFRKKDEVVALVNLVHHMGGTIRKDFDSAKVTHLIARSTHGEKYRLAVCMGTPILTPDWIRKAWE-HRDDINFHAGNELFRTEFKVPPFQDCVLSFLGFSEEEKNNMEERTQKHGGRFQ-AVGDERCTHLVVEENSIKELPFTPSKRLYVVKQEWFWGSIQ 313
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Zebrafish
Match: ect2 (epithelial cell transforming 2 [Source:ZFIN;Acc:ZDB-GENE-040831-2]) HSP 1 Score: 90.1225 bits (222), Expect = 1.022e-17 Identity = 54/219 (24.66%), Postives = 107/219 (48.86%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENK-IDLTNKVKMMHGFVS-DALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ +L I GP ++ K + LP S PL+S+ + ++ +CF+ ++++ + L N V M G + D A V LI+ S KYR+A G P++ +W+ + W ++ + + ++ ++++P + + GF+E E++ ++ ++GG F + CTHL+ + S ++ + + V EW SI+
Sbjct: 97 VFVLKDFQAPEYSFLYKNDSRILGPPAVMHCANKGEPLPFSSRPLYSMTMLNLSLCFTGFRKKDEVVALVNLVHHMGGTIRKDFDSAKVTHLIARSTHGEKYRLAVCMGTPILTPDWIRKAWE-HRDDINFHAGNELFRTEFKVPPFQDCVLSFLGFSEEEKNNMEERTQKHGGRFQ-AVGDERCTHLVVEENSIKELPFTPSKRLYVVKQEWFWGSIQ 313
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Xenopus
Match: ppp1r14b (protein phosphatase 1 regulatory inhibitor subunit 14B [Source:Xenbase;Acc:XB-GENE-485314]) HSP 1 Score: 223.016 bits (567), Expect = 2.298e-58 Identity = 237/960 (24.69%), Postives = 405/960 (42.19%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEI---HVP------GSTPKKDSKIIMD---------SKCNEI---SVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIY---------RPAANVQ----SDNWGSMNELDWGDTMKTVEVNNNKDESTVIEK-----------STMSIDA-----------------IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQS----DDSNISVATTTS-DQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKN-QCSTPVRNKALDIDWKHSDMESPIYREDPN---KPRPKLIYDENMFK-------------TP----EQWKKYRKPISPINTPEMRNGLA---RRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
+++ F + +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ N V++M G V L +V LI+ V S+KY VA+ P++ WV+ LW S Q+ + + +Y PI IC++G N +R E +++ +GG + L +N+ THLI + A GQK+ A+KWN+ V+ +W +S+ KG+ D Y++ VP G K DS+ I D S NE SV+ L+N D S + C L + + K LI GG S +T THIIV ++ + KT Y L WL ++ L + Y Y +PA N+ S G +N + + ++ ST+IE S MS+ I G+F + F + E I++ I +NAG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ + L V+S S + ER L LGA VQ+ RK P K + A+THL++ + K+ ++K W +PAVT W+ +C K+ D +YL+ S D+S IS + + + C +HP + K VT D ++ K Q NK + + ES + + +P+ K + + +FK TP ++ + P+S + ++ +A R+ A + + K + E L ++ K L VVI + + +L I +LG W +D ++VT + + +D +R+ + +V+ WLLAC +Q+ V E Y
Sbjct: 31 LYICDPFSGAVFNHLKKLGCRIVGPQVVIFCMEHQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHNYVQLMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKALWDQSNQ--QIIRYCDVNMKEYLCPIFRGCTICVTGLNSLDRKEVQRLTTLHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWNVHCVSVQWFFDSLDKGFCQDETMYKIEPATSLKSVPDTSTPTGDNKKPDSRAIYDVSQISNISTSCVNESAFNSVMTSRLDPPADALENLDISSLQAPEDLLDGCRIYLCGFGGRKLDKLRRLINSGGGVRFSQLTADVTHIIVGETDEELKQFLSKTQHRPYVLTVKWLLESFSKGHLQPENIYSHSSYQQTELSSPVQPAFNLTAQKISSTRGPLNHTHNQQADEDLLSQYTENNSTLIEDEHPKISNTNSISQMSMHEDMTSCTSQSGLADTSTIIEGGLFSRKQFLVLGFLEEDEACIIDIIKKNAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPCLEG--SRPLQECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKDMFASTHLVLKDAEGSKYEAAKKWNLPAVTMKWLLQCARTGKKADEHHYLVDSVPEEDESFISQTYKPQVSRRSMDAPCHQENHPQALKK-----------AAVTPLDMNRFQSKAFQSVISQHNK----NPQTPGGESTVLQREPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGGPNQKSRTQSTPLSEVIGRNLQLAIANSTRQTAAVTASPQLKAAEQ--KEQLENS------KVLHNVVICVSKKLIKKQGELNGIAASLGAEYRWCFD-ESVTHFI-----YHGRQNDMSREYKSVKERSGICIVSEHWLLACSEQQKRVPEALY 955 HSP 2 Score: 82.4185 bits (202), Expect = 4.079e-15 Identity = 47/147 (31.97%), Postives = 75/147 (51.02%), Query Frame = 3
Query: 3054 YDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
Y + I +GG + F TH+I G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1206 YSQLIEEIGGVVIEKQCFDPSCTHIIVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKQFIQEDDYEWGSKSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1346
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Xenopus
Match: ppp1r14b (protein phosphatase 1 regulatory inhibitor subunit 14B [Source:Xenbase;Acc:XB-GENE-485314]) HSP 1 Score: 220.32 bits (560), Expect = 1.580e-57 Identity = 196/758 (25.86%), Postives = 334/758 (44.06%), Query Frame = 3
Query: 36 FTVYFVQDT-TTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEI---HVP------GSTPKKDSKIIMD---------SKCNEI---SVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIY---------RPAANVQ----SDNWGSMNELDWGDTMKTVEVNNNKDESTVIEK-----------STMSIDA-----------------IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQS----DDSNISVATTTS-DQSNFNEICMSIDHP 2087
F V F++ + ++ +A+++IK I + + + E+ +++ F + +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ N V++M G V L +V LI+ V S+KY VA+ P++ WV+ LW S Q+ + + +Y PI IC++G N +R E +++ +GG + L +N+ THLI + A GQK+ A+KWN+ V+ +W +S+ KG+ D Y++ VP G K DS+ I D S NE SV+ L+N D S + C L + + K LI GG S +T THIIV ++ + KT Y L WL ++ L + Y Y +PA N+ S G +N + + ++ ST+IE S MS+ I G+F + F + E I++ I +NAG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ + L V+S S + ER L LGA VQ+ RK P K + A+THL++ + K+ ++K W +PAVT W+ +C K+ D +YL+ S D+S IS + + + C +HP
Sbjct: 9 FCVKFIKSSENSEYFFKAYEAIKQIQSDESLQLTEESEALLLKEKDKSLYICDPFSGAVFNHLKKLGCRIVGPQVVIFCMEHQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHNYVQLMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKALWDQSNQ--QIIRYCDVNMKEYLCPIFRGCTICVTGLNSLDRKEVQRLTTLHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWNVHCVSVQWFFDSLDKGFCQDETMYKIEPATSLKSVPDTSTPTGDNKKPDSRAIYDVSQISNISTSCVNESAFNSVMTSRLDPPADALENLDISSLQAPEDLLDGCRIYLCGFGGRKLDKLRRLINSGGGVRFSQLTADVTHIIVGETDEELKQFLSKTQHRPYVLTVKWLLESFSKGHLQPENIYSHSSYQQTELSSPVQPAFNLTAQKISSTRGPLNHTHNQQADEDLLSQYTENNSTLIEDEHPKISNTNSISQMSMHEDMTSCTSQSGLADTSTIIEGGLFSRKQFLVLGFLEEDEACIIDIIKKNAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPCLEG--SRPLQECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKDMFASTHLVLKDAEGSKYEAAKKWNLPAVTMKWLLQCARTGKKADEHHYLVDSVPEEDESFISQTYKPQVSRRSMDAPCHQENHP 760 HSP 2 Score: 85.1149 bits (209), Expect = 6.471e-16 Identity = 50/163 (30.67%), Postives = 81/163 (49.69%), Query Frame = 3
Query: 3006 EKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
E+ F S++ Y + I +GG + F TH+I G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1262 ERRFQLSSLDPQERIDYSQLIEEIGGVVIEKQCFDPSCTHIIVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKQFIQEDDYEWGSKSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1418
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Xenopus
Match: ppp1r14b (protein phosphatase 1 regulatory inhibitor subunit 14B [Source:Xenbase;Acc:XB-GENE-485314]) HSP 1 Score: 219.935 bits (559), Expect = 2.336e-57 Identity = 189/726 (26.03%), Postives = 322/726 (44.35%), Query Frame = 3
Query: 36 FTVYFVQDT-TTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEI---HVP------GSTPKKDSKIIMD---------SKCNEI---SVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIY---------RPAANVQ----SDNWGSMNELDWGDTMKTVEVNNNKDESTVIEK-----------STMSIDA-----------------IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQS 2006
F V F++ + ++ +A+++IK I + + + E+ +++ F + +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ N V++M G V L +V LI+ V S+KY VA+ P++ WV+ LW S Q+ + + +Y PI IC++G N +R E +++ +GG + L +N+ THLI + A GQK+ A+KWN+ V+ +W +S+ KG+ D Y++ VP G K DS+ I D S NE SV+ L+N D S + C L + + K LI GG S +T THIIV ++ + KT Y L WL ++ L + Y Y +PA N+ S G +N + + ++ ST+IE S MS+ I G+F + F + E I++ I +NAG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ + L V+S S + ER L LGA VQ+ RK P K + A+THL++ + K+ ++K W +PAVT W+ +C K+ D +YL+ S
Sbjct: 9 FCVKFIKSSENSEYFFKAYEAIKQIQSDESLQLTEESEALLLKEKDKSLYICDPFSGAVFNHLKKLGCRIVGPQVVIFCMEHQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHNYVQLMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKALWDQSNQ--QIIRYCDVNMKEYLCPIFRGCTICVTGLNSLDRKEVQRLTTLHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWNVHCVSVQWFFDSLDKGFCQDETMYKIEPATSLKSVPDTSTPTGDNKKPDSRAIYDVSQISNISTSCVNESAFNSVMTSRLDPPADALENLDISSLQAPEDLLDGCRIYLCGFGGRKLDKLRRLINSGGGVRFSQLTADVTHIIVGETDEELKQFLSKTQHRPYVLTVKWLLESFSKGHLQPENIYSHSSYQQTELSSPVQPAFNLTAQKISSTRGPLNHTHNQQADEDLLSQYTENNSTLIEDEHPKISNTNSISQMSMHEDMTSCTSQSGLADTSTIIEGGLFSRKQFLVLGFLEEDEACIIDIIKKNAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPCLEG--SRPLQECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKDMFASTHLVLKDAEGSKYEAAKKWNLPAVTMKWLLQCARTGKKADEHHYLVDS 728 HSP 2 Score: 85.1149 bits (209), Expect = 6.698e-16 Identity = 50/163 (30.67%), Postives = 81/163 (49.69%), Query Frame = 3
Query: 3006 EKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
E+ F S++ Y + I +GG + F TH+I G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1225 ERRFQLSSLDPQERIDYSQLIEEIGGVVIEKQCFDPSCTHIIVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKQFIQEDDYEWGSKSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1381
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Xenopus
Match: ppp1r14b (protein phosphatase 1 regulatory inhibitor subunit 14B [Source:Xenbase;Acc:XB-GENE-485314]) HSP 1 Score: 218.394 bits (555), Expect = 6.171e-57 Identity = 236/996 (23.69%), Postives = 416/996 (41.77%), Query Frame = 3
Query: 36 FTVYFVQDT-TTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEI---HVPGSTPKKDSKIIMDSKCNEI-----------SVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIY---------RPAANVQ----SDNWGSMNEL-----------DWGDTMKTVEVNNNKDESTVIEK----STMSIDA-----------------IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKN-QCSTPVRNKALDIDWKHSDMESPIYREDPN---KPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAP----------------KPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
F V F++ + ++ +A+++IK I + + + E+ +++ F + +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ N V++M G V L +V LI+ V S+KY VA+ P++ WV+ LW S Q+ + + +Y PI IC++G N +R E +++ +GG + L +N+ THLI + A GQK+ A+KWN+ V+ +W +S+ KG+ D Y++ VP ++ I S+ + I SV+ L+N D S + C L + + K LI GG S +T THIIV ++ + KT Y L WL ++ L + Y Y +PA N+ S G +N + + T+ N +DE I S MS+ I G+F + F + E I++ I +NAG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ + L V+S S + ER L LGA VQ+ RK P K + A+THL++ + K+ ++K W +PAVT W+ +C K+ D +YL+ S + S +S + C +HP + K VT D ++ K Q NK + + ES + + +P+ K + + +FK K ++ + TP G + +R + + + L ++++ TA K L VVI + + +L I +LG W +D ++VT + + +D +R+ + +V+ WLLAC +Q+ V E Y
Sbjct: 9 FCVKFIKSSENSEYFFKAYEAIKQIQSDESLQLTEESEALLLKEKDKSLYICDPFSGAVFNHLKKLGCRIVGPQVVIFCMEHQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHNYVQLMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKALWDQSNQ--QIIRYCDVNMKEYLCPIFRGCTICVTGLNSLDRKEVQRLTTLHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWNVHCVSVQWFFDSLDKGFCQDETMYKIEPATSLKSVPDTSTPTGRAIYDVSQISNISTSCVNESAFNSVMTSRLDPPADALENLDISSLQAPEDLLDGCRIYLCGFGGRKLDKLRRLINSGGGVRFSQLTADVTHIIVGETDEELKQFLSKTQHRPYVLTVKWLLESFSKGHLQPENIYSHSSYQQTELSSPVQPAFNLTAQKISSTRGPLNHTHNQQADEDLLSQYTENNSTLSKNYIEDEHPKISNTNSISQMSMHEDMTSCTSQSGLADTSTIIEGGLFSRKQFLVLGFLEEDEACIIDIIKKNAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPCLEG--SRPLQECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKDMFASTHLVLKDAEGSKYEAAKKWNLPAVTMKWLLQCARTGKKADEHHYLVDSLQYLQTYKPQVSRRS-MDAPCHQENHPQALKK-----------AAVTPLDMNRFQSKAFQSVISQHNK----NPQTPGGESTVLQREPSLHLDTPSKFLSKDKLFKPSFDVK---DALAALETP----GGPNQKSRTQSTPLSEVIGRNLQLAIANSTRQTAAVTASPQLKAAEQKENSKVLHNVVICVSKKLIKKQGELNGIAASLGAEYRWCFD-ESVTHFI-----YHGRQNDMSREYKSVKERSGICIVSEHWLLACSEQQKRVPEALY 969 HSP 2 Score: 85.1149 bits (209), Expect = 7.697e-16 Identity = 50/163 (30.67%), Postives = 81/163 (49.69%), Query Frame = 3
Query: 3006 EKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
E+ F S++ Y + I +GG + F TH+I G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1242 ERRFQLSSLDPQERIDYSQLIEEIGGVVIEKQCFDPSCTHIIVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKQFIQEDDYEWGSKSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1398
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Xenopus
Match: ppp1r14b (protein phosphatase 1 regulatory inhibitor subunit 14B [Source:Xenbase;Acc:XB-GENE-485314]) HSP 1 Score: 216.853 bits (551), Expect = 1.845e-56 Identity = 179/676 (26.48%), Postives = 300/676 (44.38%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPG----STP---KKDSKIIMD---------SKCNEI---SVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIY---------RPAANVQ----SDNWGSMNELDWGDTMKTVEVNNNKDESTVIEK-----------STMSIDA-----------------IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQS 2006
+++ F + +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ N V++M G V L +V LI+ V S+KY VA+ P++ WV+ LW S ++ V + +Y PI IC++G N +R E +++ +GG + L +N+ THLI + A GQK+ A+KWN+ V+ +W +S+ KG+ D Y++ + STP K + I D S NE SV+ L+N D S + C L + + K LI GG S +T THIIV ++ + KT Y L WL ++ L + Y Y +PA N+ S G +N + + ++ ST+IE S MS+ I G+F + F + E I++ I +NAG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ + L V+S S + ER L LGA VQ+ RK P K + A+THL++ + K+ ++K W +PAVT W+ +C K+ D +YL+ S
Sbjct: 23 LYICDPFSGAVFNHLKKLGCRIVGPQVVIFCMEHQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHNYVQLMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKALWDQSNQIIRYCDVN---MKEYLCPIFRGCTICVTGLNSLDRKEVQRLTTLHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWNVHCVSVQWFFDSLDKGFCQDETMYKIEPATSLKSVPDTSTPTGQKNFGRAIYDVSQISNISTSCVNESAFNSVMTSRLDPPADALENLDISSLQAPEDLLDGCRIYLCGFGGRKLDKLRRLINSGGGVRFSQLTADVTHIIVGETDEELKQFLSKTQHRPYVLTVKWLLESFSKGHLQPENIYSHSSYQQTELSSPVQPAFNLTAQKISSTRGPLNHTHNQQADEDLLSQYTENNSTLIEDEHPKISNTNSISQMSMHEDMTSCTSQSGLADTSTIIEGGLFSRKQFLVLGFLEEDEACIIDIIKKNAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPCLEG--SRPLQECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKDMFASTHLVLKDAEGSKYEAAKKWNLPAVTMKWLLQCARTGKKADEHHYLVDS 691 HSP 2 Score: 85.1149 bits (209), Expect = 7.256e-16 Identity = 50/163 (30.67%), Postives = 81/163 (49.69%), Query Frame = 3
Query: 3006 EKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
E+ F S++ Y + I +GG + F TH+I G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1168 ERRFQLSSLDPQERIDYSQLIEEIGGVVIEKQCFDPSCTHIIVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKQFIQEDDYEWGSKSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1324
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Mouse
Match: Topbp1 (topoisomerase (DNA) II binding protein 1 [Source:MGI Symbol;Acc:MGI:1920018]) HSP 1 Score: 152.14 bits (383), Expect = 1.797e-36 Identity = 103/411 (25.06%), Postives = 189/411 (45.99%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHV--------PGSTPKKDSKIIMDSKCNEISVIFDGSHADET--------------RLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNEL 1328
+++ F + +L+ L I GPQ + +P++ +P++++ + D+ V +S++++ + ++ V+MM G V L +V LI+ V S+KY VA+ P++ W++ LW S+ ++ + ++ ++ PI IC++G N R +Q+ ++GG + L +N+CTHLI + GQK+ A++WN+ VT +W +SI+KG+ D Y+ + P + +S + D + IS I +GS +ET L+N D S + C L + + K LI GG + + TH+IV DD + K+ + + + WL C + ++ YI Y+PA SD G+ +
Sbjct: 57 LYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQE-KKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAETRVEAKMVPDTSTPTAQSNAESHTLAD--VSHISNI-NGSCVNETMFGSTTSKLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAGIAVSDQPGNQTAV 463 HSP 2 Score: 100.908 bits (250), Expect = 6.994e-21 Identity = 130/485 (26.80%), Postives = 203/485 (41.86%), Query Frame = 3
Query: 1374 DESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSIS---SSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSK----------SSIKNQCST--PVRNKALDIDWKHSDMESPIYREDP-NKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRN---GLARRIARMELDYKDKPYNK--YLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
D+STV E+ G+F + F + + E IV+ I E+AG ++S I+ + P+ + VVT ++ C++ ++ S+ LF P+S+ S T L VISFS ER L LGA+VQ+ RK K +LA+THLI+ +P K+ ++K W +PAV W+ E KR D ++L+ + V T N + + D P P++ L I VT D ++ S + Q T PVR H D S +D KP + +TP + RK SP++ +RN LA +R + P K +L+E + KPL VV+ + + +L + +LG W++D +TVT + +D NR E E +V+ WLL C +E +H+ E Y
Sbjct: 546 DDSTVREE----------GLFSQKSFLVLGFSVENKCNIVDIIREHAGKIVSLPS----RIVADYAVVPLLGCEVDVTVGEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSG--VTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLVDNAPKQEQVLETKIP----NGVSSNPDLPA---HPDAHL-EIHRKKAVTPLDMNRFQSRAFRAVISQQRGQDPTFPPVRQPLTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVIVRNLTVALANS-SRNTDSHSASPQLKGAHLEEEETR-------KPLDSVVVCVSKKLSKKQSELNGVAASLGAEYRWSFD-ETVTHFI-----YQGRANDSNR-EYKSAKERGVHIVSEHWLLECAQEYKHLPESLY 991 HSP 3 Score: 89.3521 bits (220), Expect = 2.410e-17 Identity = 54/160 (33.75%), Postives = 82/160 (51.25%), Query Frame = 3
Query: 3012 VFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE---------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVV 3464
VF S++ Y I++LGGS+ TH++ G P NEKYLA++AAGKWVLH+SYLD + G++++E +++WG S L P T + LAL A+ W + I GAF W+ L + ++++AGG V+
Sbjct: 1265 VFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACKTAGRFVQEEDYEWGSS---SILDALPDVTEHQQKLAL--AAMRWRKRIQQSQESGIVEGAFSGWKAILRVDRPREAGFKRLLQAGGAKVL 1419
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Mouse
Match: Slf1 (SMC5-SMC6 complex localization factor 1 [Source:MGI Symbol;Acc:MGI:2145448]) HSP 1 Score: 85.8853 bits (211), Expect = 1.468e-17 Identity = 57/174 (32.76%), Postives = 88/174 (50.57%), Query Frame = 3
Query: 3120 THLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE----IGG-GAFKEWRVC-LIEKNEKYEKMCKIIEAGGGTVV-PFSEPISQLGVTHFLVNKSQCSGLPDLSQY--PCYKIEMIPSFL---SAQND 3605
THLI C +EK+LAA AAGKWVL K Y+ S G+WL+ET ++WG ++ Y + A K W E G GAF W+V L+ +++ + + +++EAG V+ P + P G+TH + + ++ S + + P Y I+ + FL QND
Sbjct: 44 THLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWG-------YKIEKDSHYSP---QMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPS---GITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQND 204
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Mouse
Match: Slf1 (SMC5-SMC6 complex localization factor 1 [Source:MGI Symbol;Acc:MGI:2145448]) HSP 1 Score: 84.7297 bits (208), Expect = 2.147e-17 Identity = 57/174 (32.76%), Postives = 88/174 (50.57%), Query Frame = 3
Query: 3120 THLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE----IGG-GAFKEWRVC-LIEKNEKYEKMCKIIEAGGGTVV-PFSEPISQLGVTHFLVNKSQCSGLPDLSQY--PCYKIEMIPSFL---SAQND 3605
THLI C +EK+LAA AAGKWVL K Y+ S G+WL+ET ++WG ++ Y + A K W E G GAF W+V L+ +++ + + +++EAG V+ P + P G+TH + + ++ S + + P Y I+ + FL QND
Sbjct: 50 THLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWG-------YKIEKDSHYSP---QMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPS---GITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQND 210
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Mouse
Match: Slf1 (SMC5-SMC6 complex localization factor 1 [Source:MGI Symbol;Acc:MGI:2145448]) HSP 1 Score: 83.9593 bits (206), Expect = 1.133e-15 Identity = 58/174 (33.33%), Postives = 88/174 (50.57%), Query Frame = 3
Query: 3120 THLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE----IGG-GAFKEWRVCLIEKNEKY-EKMCKIIEAGGGTVV-PFSEPISQLGVTHFLVNKSQCSGLPDLSQY--PCYKIEMIPSFL---SAQND 3605
THLI C +EK+LAA AAGKWVL K Y+ S G+WL+ET ++WG ++ Y + A K W E G GAF W+V L+ + +K + + +++EAG V+ P + P G+TH + + ++ S + + P Y I+ + FL QND
Sbjct: 44 THLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWG-------YKIEKDSHYSP---QMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPS---GITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQND 204
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Mouse
Match: Ect2 (ect2 oncogene [Source:MGI Symbol;Acc:MGI:95281]) HSP 1 Score: 82.4185 bits (202), Expect = 2.413e-15 Identity = 53/218 (24.31%), Postives = 101/218 (46.33%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSI-EEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FV+ F+ S L I GP +L + + LP S PL+ ++ ++ +CF+ ++E + L V M G + + V L+++ Q K+RVA G P+++ EW+ + W V+ +++++P + + GF++ E+ ++M GGS+ P + CTHLI + + + + + V EW SI+
Sbjct: 96 IFVVTDFQNSVFNDLYKADCRIVGPPVILNCAQRGEPLPFSCRPLYCTSMLNLVLCFTGFRKKEELVKLVTLVHHMGGVIRKECNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWERRNEQCFCAAVDDFR-NEFKVPPFQDCILSFLGFSDEEKHSMEEMTEMQGGSYLP-VGDERCTHLIVEENTVKDLPFEPSKKLFVVKQEWFWGSIQ 311
BLAST of DNA topoisomerase 2 binding protein 1 vs. UniProt/SwissProt
Match: sp|Q800K6|TOB1A_XENLA (DNA topoisomerase 2-binding protein 1-A OS=Xenopus laevis OX=8355 GN=topbp1-A PE=1 SV=2) HSP 1 Score: 221.476 bits (563), Expect = 3.801e-57 Identity = 234/957 (24.45%), Postives = 413/957 (43.16%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLS---------DEIHVPGSTPKKDSKIIMD-SKCNEISV------IFDGSHADET-----RLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYR---------PAANVQSDNWGSMNE------------------------LDWGDTMKTVEVNN------NKDESTVIEKSTMSIDA--IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLL----QSDDSNISVATTTSDQSNFNEICMSIDHPIS-GNKPESILPAIEESGPVTDCDQSKSSIKN-QCSTPVRNKALDIDWKHSDMESPIYREDPN---KPRPKLIYDENMFK----------------TPEQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSD-WLLACEREQRHVEEVKY 2765
+++ F ++ +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ + V++M G V L +V LI+ V S+KY VA+ P++ WV+ELW K+ ++ + + +Y PI IC++G + +R E +++ +GG + L +N+ THLI + A GQK+ A+KWN+ ++ +W +SI+KG+ D Y++ D G K +S+ + D S+ + IS F+ + A L+N D S + C L + + K LI GG + +T THIIV ++ + KT Y L WL + L Y Y+ PA N+ ++ S + L + KT N+ ++D +T +S ++ + I G+F + F + E I++ I ++AG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ +T L V+S S + ER L LGA VQ+ RK P K + A+THL++ + K+ ++K W +PAVT +W+ +C ++ D +YL+ + D ++ T Q+ I +S+ P N PE++ A VT D ++ K Q NK + + S ES + + +P+ K + + +FK P Q K R +P++ RN L IA + L +D + K L VVI + + +L I +LG W +D ++VT + + +D +R E E S + + S+ WL AC +Q+ V E Y
Sbjct: 57 LYICDPFSGAAFSHLKKLGCRIVGPQVVIFCMENQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHHYVQIMGGCVYRDLNVSVTHLIAGEVGSKKYLVAASLEKPILLPSWVKELW--EKSNQRIIRYSDVNMTEYLCPIFRGCTICVTGLSSLDRKEVQRLTALHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWNVHCISVQWFFDSIEKGFCQDETMYKIEPASTIKSVPDTSTPTGGNSKPNSRTLYDVSQISNISTSCVNESAFNSAMASRLDPPADTLENLDISSLQAPDDLLDGCRIYLCGFGGRKLDKLRKLINNGGGVRFNQLTGDVTHIIVGETDEELKQFLNKTQHRPYVLTVKWLLDSFAKGHLQPEEIYFHSSYQQTEMPSPFEPAINLTANKMSSTRDPLNHTRNHQADEDLLSQYTENNSTLIEDEHPKTSNTNSISQMSMHEDMTTCTSQSGLADTSTIIEGGLFSRKQFMVLGFLEEDEACIIDIIKKSAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPFLEG--STPLRECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKGMFASTHLVLKDAEGSKYEAAKKWNLPAVTMNWLLQCARTGRKADEDSYLVDNVPEEDKDESFISQTYKPQA----IRLSMHAPCHLENHPEALTKAA-----VTPLDMNRFKSKAFQSVISQHNK----NPQTSGGESKVLQREPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGGPNQ--KNRTQSTPLSEVIGRN-LQLAIANSTRQTAAVTASPQLKAAEKKEFDNS--KLLINVVICVSKKLIKKQGELNGIAASLGAEYRWCFD-ESVTHFI-----YHGRQNDMSR-EYKSVKERSGIYIVSEHWLFACSEQQKRVPEALY 982 HSP 2 Score: 86.2705 bits (212), Expect = 1.587e-15 Identity = 50/163 (30.67%), Postives = 81/163 (49.69%), Query Frame = 3
Query: 3006 EKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
E+ F S++ Y + I LGG + F TH++ G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1260 ERRFQLSSLDPQERIDYSQLIEELGGVVIEKQCFDPSCTHIVVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKRFIQEEDYEWGSMSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1416
BLAST of DNA topoisomerase 2 binding protein 1 vs. UniProt/SwissProt
Match: sp|Q7ZZY3|TOB1B_XENLA (DNA topoisomerase 2-binding protein 1-B OS=Xenopus laevis OX=8355 GN=topbp1-B PE=2 SV=1) HSP 1 Score: 209.534 bits (532), Expect = 1.984e-53 Identity = 231/958 (24.11%), Postives = 408/958 (42.59%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLS---------DEIHVPGSTPKKDSKIIMD-SKCNEISV------IFDGSHADET-----RLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYR---------PAANVQSDNWGSMNE------------------------LDWGDTMKTVEVNN------NKDESTVIEKSTMSIDA--IPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNE------ICMSIDHPIS-GNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWKHSDMESPIYREDPN---KPRPKLIYDENMFK----------------TPEQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSD-WLLACEREQRHVEEVKY 2765
+++ F ++ +L+ L I GPQ ++ +P++ YP++++A+ D+ + +S+++E + D+ + V++M G V L +V LI+ V S KY VA+ P++ WV+ELW S ++ + + +Y PI IC++G + +R E +++ +GG + L +N+ THLI + A GQK+ A+KW + ++ +W +SI+KG+ D Y++ D G K +S+ + D S+ + IS F+ + A L+N D S + C L + + K LI GG + +T THIIV ++ + KT Y L WL + L Y Y+ PA N+ ++ S + L + KT N+ ++D +T +S ++ + I G+F + F + E I++ ++AG V+S+ + + Y + + ++ S+ VVT ++ C+EQ ++L S+ LF P+ +T L V+S S + ER L LGA VQ+ RK P K + A +HL + + K+ ++K W +PAVT +W+ +C K+ D +YL+ +V D+S N+ I +S+ P N PE++ A VT D ++ K C + + + + + S ES + + +P+ K + + +FK P Q K R +P++ RN L IA + L +D + K L VVI + + +L I +LG W +D ++VT + + +D +R E E S + + S+ WL AC +Q+ V E Y
Sbjct: 57 VYICDPFSGAAFSHLKKLGCRIVGPQVVIFCMESQRRVPRAEYPVYNMAMADVTISCTSLDKETREDVHHYVQIMGGCVYRDLNVSVTHLIAGEVGSNKYLVAASLEKPILLPSWVKELWEKSNQ--RIIRYSDVNMTEYLCPIFRGCTICVTGLSSLDRKEVQRLTALHGGEYTGQLKMNESTHLIVQEAKGQKYECARKWIVHCISVQWFFDSIEKGFCQDETMYKIEPASTIKSVPDTSTPTGGNSKPNSRTLYDVSQISNISTSCVNESAFNSAMASRLDPPADTLENLDISSLQAPDDLLDGCRIYLCGFGGRKLDKLRKLINNGGGVRFNQLTGDVTHIIVGETDEELKQFLNKTQHRPYVLTVKWLLDSFAKGHLQPEEIYFHSSYQQTEMPSPFEPAINLTANKMSSTRDPLNHTRNHQADEDLLSQYTENNSTLIEDEHPKTSNTNSISQITCSEDLTTCTSQSGLADPSTIIEGGLFSRKQFMVLGFLEEDEACIIDIRKKSAGKVLSSQKRAIADYAVVPLLGCEVE--STVGEVVTNAWLGMCIEQEKLLDPHSNALFTPVPFLEG--STPLRECVLSVSQFMGAERDSLVYLAGLLGAKVQEFFVRKANPKKGMFARSHLDLKDAEGSKYEAAKKWNLPAVTMNWLLQCARTGKKADEDSYLVD------NVPEEDKDESFINQTYKPQAIRLSMHAPCHLENHPEALTKAA-----VTPLDMNRFKSK-ACQSVISQH--NKNPQTSGGESKVLQREPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGGPNQ--KNRTQSTPLSEVIGRN-LQLAIANSTRQTAAVTASPQLKAAEKKEFDNS--KLLINVVICVSKKLIKKQGELNGIAASLGAEYRWCFD-ESVTHFI-----YHGRQNDMSR-EYKSVKERSGIYIVSEHWLFACSEQQKRVPEALY 982 HSP 2 Score: 85.8853 bits (211), Expect = 1.911e-15 Identity = 50/163 (30.67%), Postives = 81/163 (49.69%), Query Frame = 3
Query: 3006 EKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGG-SRKNEFLQLNPTKTYGKIFLALLDASKHWHE----------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV 3461
E+ F S++ Y + I LGG + F TH++ G P NEKYLA++AAGKWVLH+SYL+ + ++++E +++WG S + +NP + L +A+ W + I GAF W+V L K +++++GG V
Sbjct: 1260 ERRFQLSSLDPQERIDYSQLIEELGGVVIEKQCFDPSCTHIVVGHPLRNEKYLASMAAGKWVLHRSYLEACRAAKRFIQEEDYEWGSMSILSAVTNINPQQRM------LAEAAMRWRKKLQGIKQNMGIAEGAFSGWKVILNVDQTKEPGFKRLLQSGGAKV 1416
BLAST of DNA topoisomerase 2 binding protein 1 vs. UniProt/SwissProt
Match: sp|Q6ZQF0|TOPB1_MOUSE (DNA topoisomerase 2-binding protein 1 OS=Mus musculus OX=10090 GN=Topbp1 PE=1 SV=2) HSP 1 Score: 152.14 bits (383), Expect = 1.257e-35 Identity = 103/411 (25.06%), Postives = 189/411 (45.99%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHV--------PGSTPKKDSKIIMDSKCNEISVIFDGSHADET--------------RLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNEL 1328
+++ F + +L+ L I GPQ + +P++ +P++++ + D+ V +S++++ + ++ V+MM G V L +V LI+ V S+KY VA+ P++ W++ LW S+ ++ + ++ ++ PI IC++G N R +Q+ ++GG + L +N+CTHLI + GQK+ A++WN+ VT +W +SI+KG+ D Y+ + P + +S + D + IS I +GS +ET L+N D S + C L + + K LI GG + + TH+IV DD + K+ + + + WL C + ++ YI Y+PA SD G+ +
Sbjct: 57 LYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQE-KKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAETRVEAKMVPDTSTPTAQSNAESHTLAD--VSHISNI-NGSCVNETMFGSTTSKLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAGIAVSDQPGNQTAV 463 HSP 2 Score: 100.908 bits (250), Expect = 4.893e-20 Identity = 130/485 (26.80%), Postives = 203/485 (41.86%), Query Frame = 3
Query: 1374 DESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSIS---SSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSK----------SSIKNQCST--PVRNKALDIDWKHSDMESPIYREDP-NKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRN---GLARRIARMELDYKDKPYNK--YLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
D+STV E+ G+F + F + + E IV+ I E+AG ++S I+ + P+ + VVT ++ C++ ++ S+ LF P+S+ S T L VISFS ER L LGA+VQ+ RK K +LA+THLI+ +P K+ ++K W +PAV W+ E KR D ++L+ + V T N + + D P P++ L I VT D ++ S + Q T PVR H D S +D KP + +TP + RK SP++ +RN LA +R + P K +L+E + KPL VV+ + + +L + +LG W++D +TVT + +D NR E E +V+ WLL C +E +H+ E Y
Sbjct: 546 DDSTVREE----------GLFSQKSFLVLGFSVENKCNIVDIIREHAGKIVSLPS----RIVADYAVVPLLGCEVDVTVGEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSG--VTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLVDNAPKQEQVLETKIP----NGVSSNPDLPA---HPDAHL-EIHRKKAVTPLDMNRFQSRAFRAVISQQRGQDPTFPPVRQPLTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVIVRNLTVALANS-SRNTDSHSASPQLKGAHLEEEETR-------KPLDSVVVCVSKKLSKKQSELNGVAASLGAEYRWSFD-ETVTHFI-----YQGRANDSNR-EYKSAKERGVHIVSEHWLLECAQEYKHLPESLY 991 HSP 3 Score: 89.3521 bits (220), Expect = 1.686e-16 Identity = 54/160 (33.75%), Postives = 82/160 (51.25%), Query Frame = 3
Query: 3012 VFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE---------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVV 3464
VF S++ Y I++LGGS+ TH++ G P NEKYLA++AAGKWVLH+SYLD + G++++E +++WG S L P T + LAL A+ W + I GAF W+ L + ++++AGG V+
Sbjct: 1265 VFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACKTAGRFVQEEDYEWGSS---SILDALPDVTEHQQKLAL--AAMRWRKRIQQSQESGIVEGAFSGWKAILRVDRPREAGFKRLLQAGGAKVL 1419
BLAST of DNA topoisomerase 2 binding protein 1 vs. UniProt/SwissProt
Match: sp|Q92547|TOPB1_HUMAN (DNA topoisomerase 2-binding protein 1 OS=Homo sapiens OX=9606 GN=TOPBP1 PE=1 SV=3) HSP 1 Score: 149.058 bits (375), Expect = 9.409e-35 Identity = 100/397 (25.19%), Postives = 186/397 (46.85%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVP----GSTPKK-----DSKIIMD--------------SKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILY-LKSDWLQACLNENRLVNVHQYIVDIYRP 1283
+++ F +L+ L I GPQ ++ +P++ +P++++ + D+ + +S+E+E + ++ V+MM G V L +V LI+ V S+KY VA+ P++ W++ LW S+ ++ I ++ ++ PI IC++G +R E +Q+ +++GG + L +N+CTHLI + GQK+ AK+WN+ VT +W +SI+KG+ D Y+ STP DS+ + D S CN ++ + + + L+N D S + C L + + K LI GG + + TH+IV D+ + K+ + + + WL C ++ +++ YI Y+P
Sbjct: 57 LYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQE-KKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLEN---LENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQP 449 HSP 2 Score: 102.449 bits (254), Expect = 1.898e-20 Identity = 120/462 (25.97%), Postives = 205/462 (44.37%), Query Frame = 3
Query: 1428 GIFYKFIFHMDNETCEKSIRIVNSITENAGTVIST-TEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQ-SDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCD----QSKS-------SIKNQCSTPVRNKALDIDWK-HSDMESPIYREDP-NKPRPKLIYDENMFKTPEQ-WKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
G+F + F + + E I N I ENAG ++S + Y + + +++ + VVT ++ C++ + S+ LF P+ + + T L VISFS E++ L LGA+VQ+ RK K + A+THLI+ + K+ ++K W +PAVT W+ E KR D ++L++ S S+ T ++ N N + +HP G + ++ + VT D QSK+ + ++P + L + H D S +D KP + +TP + ++ RKP +P++ ++N L +A + + L E S+ + APKPL VV+ + + +L I +LG W++D +TVT + +D NR E E +V+ WLL C +E +H+ E Y
Sbjct: 551 GLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGCEVEA--TVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGM--TPLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNS--DTAEHP--GTRLQTHRKTV-----VTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKN-LQLALANSSRNAVALSASPQLKEAQSEKEE--APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFD-ETVTHFI-----YQGRPNDTNR-EYKSVKERGVHIVSEHWLLDCAQECKHLPESLY 989 HSP 3 Score: 85.8853 bits (211), Expect = 1.931e-15 Identity = 52/167 (31.14%), Postives = 83/167 (49.70%), Query Frame = 3
Query: 2994 QLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE---------IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVP 3467
+L + +F S++ Y I LGG + F TH++ G P NEKYLA++AAGKWVLH+SYL+ + G +++E +++WG S L + + LAL A+ W + I GAF W+V L + +++++GG V+P
Sbjct: 1263 ELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSS---SILDVLTGINVQQRRLAL--AAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLP 1424
BLAST of DNA topoisomerase 2 binding protein 1 vs. UniProt/SwissProt
Match: sp|P32372|RAD4_SCHPO (S-M checkpoint control protein rad4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rad4 PE=1 SV=2) HSP 1 Score: 99.7525 bits (247), Expect = 5.737e-20 Identity = 61/187 (32.62%), Postives = 105/187 (56.15%), Query Frame = 3
Query: 315 SIALKDIHVCFSSIEEENKIDLTNKV-KMMHGFVSDALKANVQILISSSVQSRKYRVA--SEKGIPVVRKEWVEELWTLSKNCVQLNGVEQ-ILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL 863
S LK +C +SI+ + + +++ K K+ + SD K +V LI+ + KY+ A S I ++ EW+ L+ ++ VQ ++ +L+DK+ +P L ++CL+ + ER + V+++GG+F P+L D THLIA +SG+K+ YA KW I V EWL +SI++ + +QL
Sbjct: 4 SKPLKGFVICCTSIDLKQRTEISTKATKLGAAYRSDFTK-DVTHLIAGDFDTPKYKFAAKSRPDIKIMSSEWIPVLY---ESWVQGEDLDDGLLVDKHFLPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDL-TRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQRNAVLEPQYFQL 185
BLAST of DNA topoisomerase 2 binding protein 1 vs. TrEMBL
Match: A0A5K3EHW4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 311.612 bits (797), Expect = 6.317e-84 Identity = 259/985 (26.29%), Postives = 448/985 (45.48%), Query Frame = 3
Query: 33 SFTVYFVQDTTTDLLKQAHDSIKAID--QVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDE----IHVPGSTPKKDSKIIMDSKCNEISVIFDGS--HADETRLDNHDESD------CVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSS----VTMPSTHIIVDDCTKLTEKTD---GILYLKSDWLQACLNENRLV----------------NVHQYI-------VDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDEST----VIEKSTMSIDAIPN---GIFYKFIFHMD-NETCEKSIRIVNSITENAGTVISTTEGSTHY-ILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQIL--PLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWKHSDMESPIYREDPNKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPL-TGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVC------------IPMAKNSYLSDENRDEILKFDEDSKV-LVTSDWLLACEREQRHVEEVKYLVNID 2780
++ +YF++D T L A D++ + Q I EE + KN F++G F ++ ++ ++L ++GPQ LL Y ++ LP YPLFS AL++ V +S+ + L + ++M+HG S L +V ++I+ V S+KY V + +G+ ++ +W++E W LS+ ++ ++ I K+++PI L IC+SG + ER E ++V NGG + + + THL+ K+A G K+++AKKW + V+ WL +S+ KGYA D Y + ++ + STP S + S +IS I D + DETR D ++ P+ C L TK +I+ GG + ++ VT TH+++ ++ D G+ Y+ S+WL++C + + V N H + VD Q G +N++D + ++ N + S V+ + SI+ + G+F + F N + + + I+ + GT+I+ + + Y I P + + +SSS ++TVY+I C+ +L LD+ F+P+ I ++ L G VIS SGY +R L E LGATVQ+ RK +PS+ + A+THL+ +KPD +KFP+S WG+PAV+ W+ C +RV ++ +Q DD D S+ I P +P +S PV KS+I Q TP A +E+P R + F +SP + ++ L +++ + K + L ET D +PT + GVV + S ++L I+K LGG W +DS T ++ +P A++S + + ++ E ++ +V +W+ C+R+ + + E + D
Sbjct: 5 TYLLYFIKDLVTPLQNVAFDAVSGYENLQPIWISGEEAVTKFQDHSPKNCCFIMGRFAGATYEHFKALGSSLYGPQVLLDYLREEKPLPNVSYPLFSTALRNAIVTVTSVTGLERERLFSSIEMLHGIASRDLTDDVNVIIAPKVGSKKYIVGASRGLHILTPDWIDEAWKLSETVDPIDMLQHSFILKFKLPIFAQLVICVSGLSLEERKEVAKIVSSNGGLYSGEMKIGITTHLVVKSAGGVKYNFAKKWKVRIVSVRWLTDSVNKGYALDESDYPVKEDNQQLLKCQFSTPTSSSSVNGPSVLGDISAITDSNCLKLDETRFSLKDLTNNGLPKRSAPEQTYLCGCVIFLYGCNSSESTKLSAIIQSGGGVLCANASDKVTESLTHVVLGADSQTVPPPDIEPGVFYVTSEWLESCNQQRKRVPESEFEAPFLLKTHATNEHASVEKPTESQVDTEEIRLINQYFENGGLNDVD-----DFISIDRNPEGSAGAMKVVTPKSSSIEEVTPLDVGLFSRLRFKPSPNFSLTANPSLSELISTDGGTLINDSAAAADYQICPYVMR---QEVSSS--MITVYWINSCVAAKTLLISELDTQIGFHPVYIPASA-RLPLEGCVISLSGYVGNDRTFLTEFARALGATVQECFLRKPVPSRNLAASTHLVAAKPDGRKFPASIQWGLPAVSCSWLYACATSGRRVSEKDHPVQEDD-----PMNPQDWSH-------ISLPEKTQRPSLTF----KSTPVGQSPGRKSAI-GQLKTPAWVGA------SKQVETPSAR------------SSDAFH-----------VSPPLSEQVSRCLKTALSKTNMLPK-----RNLAET--DFCEPTKNSGILVGVVACVAKSLSERQVELNNILKQLGGDFRWNFDSNVCTHMIACPSASMLTTASPMPPARHSTVPNPLAPDVQSALEHPRIRVVLPEWVYECQRQGKRLPEKDFAFQTD 925 HSP 2 Score: 105.531 bits (262), Expect = 5.784e-19 Identity = 59/166 (35.54%), Postives = 82/166 (49.40%), Query Frame = 3
Query: 3009 KVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFL-QLNPTKTY----GKIFLA----LLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEP 3479
+VF S + + Y I LGG L+ THLI P EK+L +A+GKW+LHKSYLD + WL+E ++WGG L QL+P + G + A L A+++W GG AF +WRV ++ +IIE GGG V+ S P
Sbjct: 1086 RVFSLSGVNQDERVRYQAIISELGGDLDPGMSIGEATTHLIIHAPSRCEKFLMCMASGKWILHKSYLDACATASTWLQEDAYEWGGPGTEPLLVQLSPAQNRSAPPGTLSPAQLRDLARAARYWRLAGGEAFADWRVIFGPGCDRETSFRRIIEIGGGKVLANSPP 1251
BLAST of DNA topoisomerase 2 binding protein 1 vs. TrEMBL
Match: A0A0R3U118 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS18 PE=4 SV=1) HSP 1 Score: 311.612 bits (797), Expect = 7.834e-84 Identity = 259/985 (26.29%), Postives = 448/985 (45.48%), Query Frame = 3
Query: 33 SFTVYFVQDTTTDLLKQAHDSIKAID--QVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDE----IHVPGSTPKKDSKIIMDSKCNEISVIFDGS--HADETRLDNHDESD------CVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSS----VTMPSTHIIVDDCTKLTEKTD---GILYLKSDWLQACLNENRLV----------------NVHQYI-------VDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDEST----VIEKSTMSIDAIPN---GIFYKFIFHMD-NETCEKSIRIVNSITENAGTVISTTEGSTHY-ILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQIL--PLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWKHSDMESPIYREDPNKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPL-TGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVC------------IPMAKNSYLSDENRDEILKFDEDSKV-LVTSDWLLACEREQRHVEEVKYLVNID 2780
++ +YF++D T L A D++ + Q I EE + KN F++G F ++ ++ ++L ++GPQ LL Y ++ LP YPLFS AL++ V +S+ + L + ++M+HG S L +V ++I+ V S+KY V + +G+ ++ +W++E W LS+ ++ ++ I K+++PI L IC+SG + ER E ++V NGG + + + THL+ K+A G K+++AKKW + V+ WL +S+ KGYA D Y + ++ + STP S + S +IS I D + DETR D ++ P+ C L TK +I+ GG + ++ VT TH+++ ++ D G+ Y+ S+WL++C + + V N H + VD Q G +N++D + ++ N + S V+ + SI+ + G+F + F N + + + I+ + GT+I+ + + Y I P + + +SSS ++TVY+I C+ +L LD+ F+P+ I ++ L G VIS SGY +R L E LGATVQ+ RK +PS+ + A+THL+ +KPD +KFP+S WG+PAV+ W+ C +RV ++ +Q DD D S+ I P +P +S PV KS+I Q TP A +E+P R + F +SP + ++ L +++ + K + L ET D +PT + GVV + S ++L I+K LGG W +DS T ++ +P A++S + + ++ E ++ +V +W+ C+R+ + + E + D
Sbjct: 5 TYLLYFIKDLVTPLQNVAFDAVSGYENLQPIWISGEEAVTKFQDHSPKNCCFIMGRFAGATYEHFKALGSSLYGPQVLLDYLREEKPLPNVSYPLFSTALRNAIVTVTSVTGLERERLFSSIEMLHGIASRDLTDDVNVIIAPKVGSKKYIVGASRGLHILTPDWIDEAWKLSETVDPIDMLQHSFILKFKLPIFAQLVICVSGLSLEERKEVAKIVSSNGGLYSGEMKIGITTHLVVKSAGGVKYNFAKKWKVRIVSVRWLTDSVNKGYALDESDYPVKEDNQQLLKCQFSTPTSSSSVNGPSVLGDISAITDSNCLKLDETRFSLKDLTNNGLPKRSAPEQTYLCGCVIFLYGCNSSESTKLSAIIQSGGGVLCANASDKVTESLTHVVLGADSQTVPPPDIEPGVFYVTSEWLESCNQQRKRVPESEFEAPFLLKTHATNEHASVEKPTESQVDTEEIRLINQYFENGGLNDVD-----DFISIDRNPEGSAGAMKVVTPKSSSIEEVTPLDVGLFSRLRFKPSPNFSLTANPSLSELISTDGGTLINDSAAAADYQICPYVMR---QEVSSS--MITVYWINSCVAAKTLLISELDTQIGFHPVYIPASA-RLPLEGCVISLSGYVGNDRTFLTEFARALGATVQECFLRKPVPSRNLAASTHLVAAKPDGRKFPASIQWGLPAVSCSWLYACATSGRRVSEKDHPVQEDD-----PMNPQDWSH-------ISLPEKTQRPSLTF----KSTPVGQSPGRKSAI-GQLKTPAWVGA------SKQVETPSAR------------SSDAFH-----------VSPPLSEQVSRCLKTALSKTNMLPK-----RNLAET--DFCEPTKNSGILVGVVACVAKSLSERQVELNNILKQLGGDFRWNFDSNVCTHMIACPSASMLTTASPMPPARHSTVPNPLAPDVQSALEHPRIRVVLPEWVYECQRQGKRLPEKDFAFQTD 925 HSP 2 Score: 92.4337 bits (228), Expect = 6.107e-15 Identity = 61/193 (31.61%), Postives = 84/193 (43.52%), Query Frame = 3
Query: 3009 KVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEP----------------------CLN--EKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFL-QLNPTKTY----GKIFLA----LLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTV---VPFSEP 3479
+VF S + + Y I LGG L+ THLI P C+ EK+L +A+GKW+LHKSYLD + WL+E ++WGG L QL+P + G + A L A+++W GG AF +WRV ++ +IIE GGG V V F P
Sbjct: 1086 RVFSLSGVNQDERVRYQAIISELGGDLDPGMSIGEATTHLIIHAPSKSSTRSIIDYQGAVALTCVRLCVGRCEKFLMCMASGKWILHKSYLDACATASTWLQEDAYEWGGPGTEPLLVQLSPAQNRSAPPGTLSPAQLRDLARAARYWRLAGGEAFADWRVIFGPGCDRETSFRRIIEIGGGKVSCLVSFRRP 1278
BLAST of DNA topoisomerase 2 binding protein 1 vs. TrEMBL
Match: H2KQP9 (DNA topoisomerase 2-binding protein 1 OS=Clonorchis sinensis OX=79923 GN=TOPBP1 PE=4 SV=1) HSP 1 Score: 311.997 bits (798), Expect = 9.011e-84 Identity = 258/981 (26.30%), Postives = 421/981 (42.92%), Query Frame = 3
Query: 36 FTVYFVQDTTTDLLKQAHDSIKAIDQVXXXX--XXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDS--------KIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPD-SRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVS----SVTMPSTHIIVDDCTKLT----EKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAAN--------------------------VQSDNWGSMNELDWGDTMKTVEVNNNKD----ESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIR--IVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQN--QILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGN--KPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALD-----------IDWKHSDMESPIYREDP----NKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIA----RMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVC----IPMAKNS-YLSDENRD---EILKFDEDSKVLVTSDWLLACE 2732
F + FV D T LL A D++ + + + E + K FV FE ++L S+ I+GPQ +L Y ++ LPK YPLFS AL +S+ + L ++M+HG S L V ++I+ V S+KY V + +G+ ++ W+ E W LS ++ + ++Y++P+ L IC+SG + ER E +V+++GG + + V + THLI K A G K+S+AKKW I TV+ WL++S+ KGYA D + Y++S+ STP D+ I + S N S D +H+D ++ VP I +C F L E + L+ E GG + + V+ TH++V T T + +LY+K WL AC + ++ Y++ + A + S M++ G ++NNK +T I + S +G F F + +E K IR + SI + G V+ + + P F + + + S +VT +IE C+ ++ Q+ L + F PI L VIS SG+ +R LL LGA VQ+ RK +PS+ + A+THL+ +KPD +K+P+++SWGIP V++ W+ C R +V ++ +Q+ + TS+ +N SGN + E +L I+ + S+ K STP DW +++++ I N PRP E + K ++N +AR A +++L Y+ +P A PL GVVI + + ++L I + LGG W YD T ++ + A S + S E +D ++ K +V WL +CE
Sbjct: 45 FEIVFVNDHATPLLSAAFDAVSSYENLTTKRLDEVEIMNRYPKQLPKRTSFVFCRFEGECFEHLRSMGAAIYGPQIILHYVRENKALPKVSYPLFSTALMGAIATVTSVTGSEREYLLRSIQMLHGQASRDLFDGVNVVITPKVGSKKYLVGASRGLHILLPSWISEAWRLSSIQDPIDMMLPAYTERYRVPVFSQLVICVSGLSAEERKEVSDLVLKHGGRYSGVMKVGETTHLIIKQAVGLKYSHAKKWKIQTVSLRWLVDSVNKGYALDEEDYRVSESCET-SSTPVGDANKRSFSFDNISVISHVNNASTRIDETHSDHQHAESFLRPKPVPRVPLILSNCVFTLFGCTREESVLFSKLVGELGGNLCTELPDQVSEAVTHVLVGSATNATTLLQTREKDMLYVKGSWLVACKESGQRLSETNYLIPLTEDAEDRTTVVPADEEPKRIVDTEDLQLINQYFGSGGLADMDDFTTGSQNLKPTISNNKTLPDATNTDITVANGSTTVNGDGFFSGLSFLLHDELSAK-IREELRKSICSSGGRVVDSPHNVDFLVAP-FFVSSLPKLPKSCMLVTAPWIEHCIAESGLQVDDLLKEPAFVPIERTG---APPLEECVISLSGFVGRDRSLLTAYAQCLGALVQECFLRKPVPSRNLAASTHLVSAKPDGRKWPAAQSWGIPTVSRSWLYACAERWMKVRELDFPVQNPSGDTQTQVATSNPTNAQ----------SGNLLQTERVLKEIQAN--TQQIQPSEPHDKPHVSTPASGHKASGSDSLLGTLRTPDWVCNNLQTDIGNSSKDSLDNFPRPSPPLSEQVAKC------------------LKNAVARTAALPKRKLDLSYE----------------EPDA-APLRGVVICVAKHLSSRQVELNGITRQLGGDFKWIYDPLVCTHIIAEYETVGQAPPSDHQSGEQQDPYPDVTAARSAGKFIVNPRWLTSCE 972 HSP 2 Score: 114.775 bits (286), Expect = 9.186e-22 Identity = 72/232 (31.03%), Postives = 106/232 (45.69%), Query Frame = 3
Query: 2976 PASEITQLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFL-QLNPT----------------KTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQL-GVTHFLVNKSQCSGLPDLSQYPC----YKIEMIPSFLSAQND 3605
PA+ + V FS + HY + LGG ++ S THLI P +EKYL +A GKW+LHKSYLD + + +W++E F+WGG L QL+P + L A++HW GG AFK WRV +K ++IEAG G V+ P VTH KS+ S + +Q P +I+ + ++L+A ++
Sbjct: 1209 PATREPEPPRRYVISFSGLPNDARDHYAHVVSQLGGEVDSQLTISEHTTHLIVHTPTRSEKYLICLATGKWILHKSYLDACLRESRWVDECNFEWGGPGTEPLLMQLSPAVLAVGPNANNSKVHEQRQQANQMRELARAARHWRLAGGKAFKNWRVIFGPGCDKETSFRRVIEAGAGQVLASGPPYPPASSVTHSFY-KSRSSTSVNRNQLPADYEWLRIDYLLAYLTAGSE 1439
BLAST of DNA topoisomerase 2 binding protein 1 vs. TrEMBL
Match: A0A183SZV8 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS9756 PE=4 SV=1) HSP 1 Score: 311.612 bits (797), Expect = 1.018e-83 Identity = 272/1005 (27.06%), Postives = 450/1005 (44.78%), Query Frame = 3
Query: 36 FTVYFVQDTTTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFG----KNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSD----EIHVPGSTPK-----------KDSKIIMDSKCNEISVIFDGSHADETRLDNHDESD--CVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGG----KIVSSVTMPSTHIIVDDCTKLTEKTD---GILYLKSDWLQACLNENRLVNVHQY------------IVDIYRPAAN-VQSDNW---------GSMNELD-------WGDTMKTVEVNNNK----DESTVIEKSTMSIDA---------IP----NGIFYKFIFHMDNETCE-KSIRIVNSITENAGTVISTTEGSTHY-ILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQIL--PLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTT---SDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWKHSDMESPIYREDPNKPRPKLIYDENMFKTPEQWKK--YRKPISPINTPEMRNGLARRIARM-ELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVV---CIPM------AKNSYLSDENRDEILKFD-EDSKVLVTSDWLLACEREQRHVEEVKYL 2768
+ +YF++D +T L A +++ + ++ WIE Q F KN F++G F + ++L I+GPQ LL Y + LP +PLFS AL+ HV +S+ + + L N ++++HG S L +V +LI+ V S+KY V + +G+ VVR +W+EE W LS+ L+ ++ ++ K+++PI +L IC+SG + ER E ++V NGG + + V + THL+ K+A G K+++AKKW I V+ WL +S+ KGYA D Y +S+ V STP D I D+ C +++ G D L NH+ D ++ DC L + ++ NG K+ VT TH+++ +K ++ G+ Y+ SDWL C + Y I+D N V +D G M E+D G+ KT V+ +K DE T ++T S IP +G+F F F +++E + +S ++ SIT G V Y I P + + IK + VT Y+I CL ++L LDS+ F PI I S+ L VIS SGY ER L LGATVQ+ RK +PS+ A+THL+ +KPD +K+P+++ WG+PAV+ W+ C +R+ ++L++ D+ + T + Q++ + P ++P A ++S S+ S Q +++P + + D+ +TP + ISP + ++ L +++ +L ++ + D T L GVV+ + S + + +VK LGG W +D++ T ++ C+ A S LS + + + K++VT DW+ AC+R R + E +L
Sbjct: 6 YRLYFIKDDSTPLQNAAFEAVSGYENLRPEWIEGNTAR--QRFPDTTPKNCCFIMGKFCGPFYDHFKALGSSIYGPQVLLDYLREQRPLPNVSHPLFSTALRGAHVTVTSVTGQERERLFNSIELLHGESSRDLTDSVNVLIAPKVGSKKYIVGASRGVSVVRPDWIEEAWRLSEILDPLDMMQPDMLLKFRLPIFSHLVICVSGLSLEERKEVSKIVSVNGGRYSGEMKVGETTHLLVKSAGGVKYNFAKKWKIRIVSVRWLTDSVSKGYALDEADYPVSETSGSRTKVGASTPSASIHPNDPSVLADISAITDTTCLQVNDTCVGCFKD---LTNHNVLDNKSPKKTQFLRDCVILLYGCNSSELASLSKIVSTNGAILCSKVSDKVTESLTHVVLGADSKNIPPSNIEPGVFYVTSDWLIGCDESGSRLPEKNYQAPFLSVPEKTSIIDGKEVTENPVDADELQLINQYFGDGGMAEVDDFLSLNTKGEAKKT-SVSVSKPVPVDEPTPTMQATSSPPTTSDTLAGCDIPSDLISGLFAGFSFRVNSEFSKYQSPGLLESITMEGGLVNDDPASPADYTICPYVIRSAIK----DSGPVTEYWIRSCLNSKKLLIQELDSEIGFRPIHIPSS-IPLPLSDCVISLSGYVGIERTFLTNFGRSLGATVQECFLRKPVPSRGFTASTHLVTAKPDGRKWPAAQLWGLPAVSCGWLYACAKAGRRLPETDFLVKQTDTAAEASDLTRQSTAQTSMATTLTNASFPSGASRPSL---AFKDSEKTPQMQPSRQSTGIQ-----------------GLKTPTW-----------VTDDARLQTPSTLGSADAKLHISPPLSEQVSRCLKAALSKTSQLPKRNLSSTDFKDATCGRM------GILVGVVVCVAKSLGERQVAINNLVKELGGDFRWTFDAQVCTHMIADRCLSSLLAASPAPGSLLSAAAQPSDVSLALQHGKLVVTPDWVHACQRAGRRLPEADFL 962 HSP 2 Score: 107.071 bits (266), Expect = 1.996e-19 Identity = 58/157 (36.94%), Postives = 81/157 (51.59%), Query Frame = 3
Query: 3009 KVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFL-QLNPTKTY-GKIFLA------LLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGG 3455
++F S + + + Y + LGG L+ S THLI P +EK+L ++AAGKWVLHKSYLD + WL ET ++WGG L QL+P + G L+ L A+++W GG AF WRV ++ +IIE GGG
Sbjct: 1120 RLFSLSGLTQEERERYANIVHELGGELDNGLAVSEATTHLILHAPTRSEKFLMSLAAGKWVLHKSYLDACSAASTWLSETAYEWGGPGTEPLLVQLSPAPSASGSGALSANQLRELAKAARYWRIAGGRAFAGWRVIFGPGCDRETSFRRIIETGGG 1276
BLAST of DNA topoisomerase 2 binding protein 1 vs. TrEMBL
Match: A0A1S8WJD0 (BRCA1 protein OS=Opisthorchis viverrini OX=6198 GN=X801_09846 PE=4 SV=1) HSP 1 Score: 310.457 bits (794), Expect = 3.528e-83 Identity = 268/982 (27.29%), Postives = 431/982 (43.89%), Query Frame = 3
Query: 36 FTVYFVQDTTTDLLKQAHDSIKAIDQVXXXX--XXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHA----DETRLD-NHDESDCVPD-----SRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVS----SVTMPSTHIIVDDCTKLTE----KTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAAN----VQSDN-----------------WGS-----MNELDWGDTMKTVEVNNNK---DESTV-IEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIR--IVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQN--QILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGN--KPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALD-----------IDWKHSDMESPIYREDP----NKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIA----RMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVC-------IPMAKNSYLSDENR-DEILKFDEDSKVLVTSDWLLACE 2732
F + FV D T LL A D++ + + + E + K FV FE ++L S+ I+GPQ +L Y ++ LPK YPLFS AL +S+ + L + ++M+HG S L V ++I+ V S+KY V + +G+ ++ W+ E W LS ++ + ++Y++P+ L IC+SG + ER E +V+++GG + + V + THLI K G K+S+AKKW I TV+ WL++S+ KGYA D + Y++S+ STP D+ S N ISVI ++A DETR D H ES P I +C F L E + L+ E GG + + V+ TH++V T T + +LY+K WL AC + ++ Y+V + A + V +D +GS M++ G V+N+K D + + I + S +G F F + +E K IR + SI + G V+ + + P F + + S +VT +IE C+ ++ Q+ L + F PI L VIS SG+ +R LL LGA VQD RK +PS+ + A+THL+ +KPD +K+P+++SWGIP V++ W+ C R +V ++ +Q+ +I +TS+ +N SGN + E +L I+ + S+ K STPV + DW + +++ I N PRP E + K ++N +AR A +++L Y+ +P A PL GVVI + + ++L I + LGG W YD T ++ +P + N ++ ++ K +V WL +CE
Sbjct: 44 FEIVFVNDHATPLLSAAFDAVSSYENLTTKRLDEVEIMNRYPKQLPKRTSFVFCRFEGECFEHLRSMGAAIYGPQIILHYVRENKPLPKVSYPLFSTALMGAIATVTSVTGSEREYLLSSIQMLHGQASRDLFDGVNVVITPKVGSKKYLVGASRGLHILLPSWISEAWRLSSIQDPIDMMLPAYTERYRVPVFSQLVICVSGLSAEERKEVSDLVLKHGGRYSGVMKVGETTHLIIKQPVGLKYSHAKKWKIQTVSLRWLVDSVNKGYALDEEDYRVSESCET-SSTPVGDANKRSFSFDN-ISVISHVNNASTRIDETRSDCQHAESFIRPKLVPRVPLILSNCVFTLFGCTREESASFSKLVGELGGHLCTELPDQVSEAVTHVLVGSATNATALLQTREKDMLYVKGSWLVACKESGQRLSETNYLVPLTEDAEDRTTVVSADEEPKRIVDTEDLQLINQYFGSGGLADMDDFTSGSQNLKPTVSNDKTLPDATNIDITVANGSTTVSGDGFFSGLSFLLHDELSAK-IREELKKSIFSSGGRVVDSPHNVDFLVAP-FFVSSFPKLPKSCVLVTAPWIEHCIAESGLQVDELLKEPAFVPIERTG---APPLKDCVISMSGFVGRDRSLLTAYAQCLGALVQDCFLRKPVPSRNLAASTHLVSAKPDGRKWPAAQSWGIPTVSRSWLYACAERWMKVKELDFPVQNPSGDIPTQVSTSNPTNGQ----------SGNLLQTERVLKEIQAN--TKQMQPSEPHDKPHVSTPVPGHKVSGSDSLLGTLRTPDWVCNSLQTDIGNSSKDSLDNFPRPSPPLSEQVAKC------------------LKNAVARTAALPKRKLDLSYE----------------EPDA-APLRGVVICVAKHLSSRQVELNGITRQLGGDFKWIYDPLVCTHIIAEYETVGQVPPSDNQSSGQQDPYPDVTAARSAGKFIVNPRWLTSCE 971 HSP 2 Score: 115.546 bits (288), Expect = 5.290e-22 Identity = 74/233 (31.76%), Postives = 107/233 (45.92%), Query Frame = 3
Query: 2976 PASEITQLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFL-QLNPT----------------KTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQL-GVTH-FLVNKSQCS----GLPDLSQYPCYKIEMIPSFLSAQND 3605
PAS + V FS + HY + LGG ++ S THLI P +EKYL +A GKW+LHKSYLD + + +W++E F+WGG L QL+P + L A++HW GG AFK WRV +K ++IEAG G V+ P VTH F ++S S LP ++Y +I+ + ++L+A +
Sbjct: 1208 PASREPEPPRRYVISFSGLPNDARDHYAHVVSQLGGEVDSQLTISEHTTHLIVHTPTRSEKYLICLATGKWILHKSYLDACLRESRWVDECNFEWGGPGTEPLLMQLSPAVPAVGPNANNSKIHEQRQQANQMRELARAARHWRLAGGKAFKNWRVIFGPGCDKETSFRRVIEAGAGQVLASGPPYPPASSVTHSFYKSRSSTSVNRNELP--AEYEWLRIDYLLAYLTAGTE 1438
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Cavefish
Match: topbp1 (DNA topoisomerase II binding protein 1 [Source:NCBI gene;Acc:103036620]) HSP 1 Score: 208.764 bits (530), Expect = 3.762e-54 Identity = 176/727 (24.21%), Postives = 322/727 (44.29%), Query Frame = 3
Query: 33 SFTVYFVQ--DTTTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL-------SDEIHVPG-STPKKDSKIIMD-------SKCNEISVIFDGSH---ADETRLDNHDESD-----CVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTK-----LTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSD-----------------------NWGSMNELD----WGDTMKTV------EVNNNKDESTVI-------EKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTV-ISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLL 2000
+F V FV+ +L ++A+++I + K + ++ + ++V F S+ ++ L I P +L + +PK+ P++++A+ D+ V +S+++E + D+ + V++M G V L +V L++ V S+KY VA+ G PV+ WV+ W S++ + + ++ Y P+ +C++G + ER E +++ +GG++ L +N+CTHLI SGQK+ +A+KWN+ ++ WL +SI+KG+ + +Y + D+ P STP SK D S + +S+ + + A +R++ D D P + C L + + K L+ GG + THI++ + + L++ + WL + L+ V Y + P A + D + E D + D +TV N+ K S+V+ + ST++ +A G+F F + E ++ + EN G V + G Y + + ++ ++ V T ++ C+EQ +LPL S LF P+++ L V+S S + ER+ L + LGA+VQD R K +LA+THL++ P+ K+ +++ WG+PAVT WI E K + YL+
Sbjct: 8 AFMVKFVEHNGQKRELGQKAYEAIVELQSEKYVQTIGEEAALKLDHNDKSLYVFSDFTSSAFEHCRKLGCRIVSPLVVLFCLQQQRCVPKAEQPVYNMAMADVTVTCTSLDKEVRTDVMDLVQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAANLGKPVLLPTWVKACWEKSQD--SMFRYSDLRVEDYLCPVFKGCTVCVTGLSTVERKEVQRLCELHGGTYTGQLKMNECTHLIVSEPSGQKYEFARKWNVYCISVHWLFDSIEKGFCQEESRYTVERGDKKREDKTGRPNTSTPTGSSKCKEDGASLLGLSHISNVSMNVNETAMTTATMSRIEPADPIDSFDVTVCPADDLLDGCKLYLCGVTGKRLEKLRRLVNAAGGLRFNQPGEELTHIVMGEPDQDVKNFLSKANHRPHVVTVQWLLDSFSRGSLLPVEGYFHPSFLPPAPAEVDMPALRPVAPRSRPSIAPAPAPSPARHAKAEEDLLSQYMDNDQTVVELPPAPENSKKAHSSVLQDPGAPGQDSTLA-EASEGGLFRGKRFLLVGFGPEAEGQLSMLVMENMGKVLVGRFRGVADYAIVPLLGCEVE--ATVDEVATDSWLAMCVEQQCLLPLGSHPLFTPVAVKEGCLP--LKECVLSVSQFTGAERESLIQLAKHLGASVQDYFVRTANQRKGMLASTHLVLQTPEGTKYVAAQKWGLPAVTMRWILESARTGKVANESRYLV 727 HSP 2 Score: 89.7373 bits (221), Expect = 1.498e-17 Identity = 57/176 (32.39%), Postives = 88/176 (50.00%), Query Frame = 3
Query: 3015 FMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE-IGG-----GAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQ 3524
F S+++ Y I LGG + F +H+I G P NEKYLAA+AAGKW+LH+SYL+ ++G +L E +++WG L PT T + LAL ++ W + + G GAF W V L + + +++++GG V+P P TH + S+
Sbjct: 1278 FQLSSLSPQERIDYSHVIEELGGIVLEKQCFDPSCSHIIVGYPLRNEKYLAAMAAGKWILHRSYLEACRAEGYFLVEEDYEWG---SRSILDAVPTVTSQQKRLAL--SALRWRKALQGRADKEGAFGGWIVMLNIDHARDAGFRRLLQSGGAKVLPGPSPSLYKDTTHLFADFSR 1448
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Cavefish
Match: ect2 (epithelial cell transforming 2 [Source:ZFIN;Acc:ZDB-GENE-040831-2]) HSP 1 Score: 98.2117 bits (243), Expect = 2.528e-20 Identity = 62/220 (28.18%), Postives = 106/220 (48.18%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSI-EEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVND--CTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ YL I GP +L GK + LP S PL+S + ++ +CF+ ++E ++L + V M G + A V LI+ S KYR+A G P++ +W+ + W GVE+ +++P + + GF+E E++ ++ +++GG F L V D CTHL+ + S ++ + + V EW SI+
Sbjct: 66 VFVLKDFQSPYYSYLYKNDNRILGPPVILHCAGKGEPLPFSSRPLYSTTMLNMSLCFTGFRKKEEVVNLVSLVHHMGGTIRKDFSAKVTHLIAHSTHGEKYRLAVCMGTPILTPDWIRKAWEHKDEINFHAGVEEFRT-AFKVPPFQDCVLSFLGFSEEEKNNMEERTLKHGGQF---LEVGDEKCTHLVVEENSIKELPFVPSKRLYVVKQEWFWGSIQ 281
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Cavefish
Match: slf1 (SMC5-SMC6 complex localization factor 1 [Source:ZFIN;Acc:ZDB-GENE-141216-402]) HSP 1 Score: 57.7658 bits (138), Expect = 7.851e-8 Identity = 44/159 (27.67%), Postives = 75/159 (47.17%), Query Frame = 3
Query: 3012 VFMFSNIAKTLEQHYD--EEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE-----IGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVP 3467
VF S I K L++ + + I+ L GS S++ MTHLI +EK+++A AGKW++ ++ +S+ Q WL E ++ + P+ T + + W E + GAF+ W VCL ++ M +I++AG + P
Sbjct: 7 VFQMSGI-KNLQKKRELLQGIKCLHGSYIGGSEYREEMTHLIVIHASASEKFISA-CAGKWIVTPEFVLDSVKQNAWLSEALYELNLTANTR----TPSMT---------NPLQKWREKVARGVVSGAFQGWTVCLHIEDPDRRSMFEILKAGKAVIDP 150
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Sea Lamprey
Match: topbp1 (DNA topoisomerase II binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-060626-1]) HSP 1 Score: 211.075 bits (536), Expect = 1.822e-55 Identity = 229/1052 (21.77%), Postives = 424/1052 (40.30%), Query Frame = 3
Query: 42 VYFVQDTTTD--LLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL------------------SDEIHVPGSTP---------------KKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLL--DYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTK-----LTEKTDGILYLKSDWLQACLNENRLVNVHQYI---------VDIYRPAANVQS---------------DNWGSMNELDWGDTMKTVE---------------VNNNKDESTVIEKS---TMSIDAIPN---------------------GIFYKFIFHMDNETCEKSIRIVNSITENAGTVI-STTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDID-WKHSDMESPIYREDPNKPRPKLIYDENMFK------TPEQWKKYRKPISP----------INTPEMRNGLARRIARMELDYKDKPYNKYLDETLS----------DTYDPTAPKP-----------LTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
V FV+D + K+A++ I I L+ + + T ++V F + +L + + GPQ +L ++ +PK+ +P++++AL D + ++++++ + ++ + +M G V + V L++ V S+KY VA+ P++ W+ W S+ + + G + ++K+ P L + ++G + ER + +++V ++GG++ L +N+CTHLI GQK+ +A+KWN+ VT +WL +S+++G D Y + S PGS + + + S + V+ G+ A+ LD+ D + + C Q+ + + + K L+ GG + + THIIV D + L ++ + + WL C + RL+ Y+ + + P A V S G + GD M+ + V+ N + T E+S T I+A+P+ GIF F + + ++ + ++E+ G ++ + HY + + ++ ++ VVT ++ C+EQ ++L L+S+ LF P+ + HY L V+S S + ER L +LGA VQ+ RK P K + A+THL++ + KF ++ W +PAV W+ E + R + ++ DD T QS E+ + P ++ + TD S +++++ TP LD + ++ + + E +L+ +++ TP ++ K I P + +PE G A R A P ++ L+ D P PK L+GVVI + +L I +LG W++D + VT V A ++N E + +V+ WL AC +EQ+HV E Y
Sbjct: 11 VKFVEDNENESKYFKEAYEKICKIQSESLLQRVDAAKVLTLKEKDRSLYVCDPFHGVAFDHLVKMGCRVVGPQVVLFCLDRERCVPKAEHPVYNMALADAVLSCTNLDKDVREEMHRLIGLMGGRVLRDFTSAVTHLVAGEVGSKKYLVAASLKKPIMLVSWITTCWEASQERM-VCGTDNEWLEKHMCPPLQGCMLSVTGLSTQERRDIQRLVTKHGGTYSGELKMNECTHLIVHKPHGQKYEFARKWNVACVTVQWLHDSVERGACQDESLYSVLPLDDIEGGPQEPSTSTPSPSRGRPGSCAMSMSNVSSISNISMSRINETVSTTSMATRLEVMAMGARAEVDELDSLDPAHLYGLDSLLDGCKAQIFVCGFSGKRLEKLRRLVNLGGGVRYNQNSADVTHIIVGDRGRERDLTLVQENSMRNVVTAKWLVDCFTQRRLLPTELYLHPDYTAPEEILLQAPLAPVASAPSQQRVPPLTAQGPAGRGRGIRSNAGDGMERTDDELMLQYSQSTADGMVSRNATDRTYTEESHTNTTIINAMPSTRLLASMATKGDSTLCEDSGAGIFSGKRFAVVGFSADEESELALLVSEHGGKMLPKNSRAVAHYAVVPLLGCEVE--NTVHEVVTNTWLVMCVEQQKLLELNSNPLFTPVPVLEGHYP--LSACVLSISQFTGTERDSLIFLAERLGARVQEFFVRKANPKKNMHASTHLLVREASGCKFEAAIKWDLPAVGVGWLLESARKGCRAKEHRHTVRLDD--------TEGQSREQEM-------------PNAAPVVDAAHTPTD---SSLALESKFVTP-----LDFNRFRSKTFHNVLAAERDGTASSELVQHFFLYQIFLRKDTPSKFLCRDKLIKPCFDVKDSLKALESPEGGQGAADRSA------SGTPLSQLFRNNLNVALANSTRPVDPASPVLPKAVQREQKETTSILSGVVICVSKKLSKRQAELNSIAASLGAEYRWSFDEE-VTHFVYQGRA------NDNSQEYRVVRDRGIHVVSEHWLHACAQEQKHVAETLY 1015 HSP 2 Score: 84.7297 bits (208), Expect = 1.191e-16 Identity = 64/211 (30.33%), Postives = 102/211 (48.34%), Query Frame = 3
Query: 3009 KVFMFSNIAKTLEQHYDEEIRNLGGSLELNSD-FSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWL-EETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASK-----HWHEIGG--GAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQC------SGLPDLS--QYPCYKIEMIPSFL 3590
+ F S+++ Y + I L G + L+ F +H+I G P NEKYLA++AAGKWVLHKSYL+ + G+++ +E E++WG S + L N T ++ A + K E G GAF W+V L + K +++++GG V+ E + TH V+ ++ +GL + C + E I FL
Sbjct: 1298 RYFQLSSMSAQERIDYLQLIEQLEGGVVLDKQYFDPSCSHIIVGNPLRNEKYLASMAAGKWVLHKSYLEACRAMGRFVQQEEEYEWGSSHILDALA-NLTTQQRRLATAAMRWRKKLQLQRRQEPGAQVGAFGGWKVILNIEQSKESGFRRLLQSGGAEVLSSGEAQALEEATHLFVDVARLRSEEVRTGLLQAAAQHVHCLRPEYIADFL 1507
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Nematostella
Match: EDO38946 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBH5]) HSP 1 Score: 158.688 bits (400), Expect = 4.103e-39 Identity = 98/350 (28.00%), Postives = 167/350 (47.71%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQ-LSDEIHVPGSTPK--------KDSKIIMDSKC--NEISVIFDGSHADETRLDNHD-------------ESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV 1154
+++L FE YL+S K I GPQC+L+ LP S +P+++ +L+++H C +S+ + + L + + MM G V +V LI+ V S+KY VA PV+ EWV LW K+ + G + D+++ PI IC++G + R E KQ+ +NGG + LN+N CTHL+ G+K+ +A+KWNI V+ +W + I+ G+ + Y+ LS +++ +P K +K D + N + S + T ++N + +S VP S C L + + K +I GG + + +H++V
Sbjct: 6 IYILDPFEGDHFGYLKSQKCRICGPQCVLSCLKTKTSLPNSSFPVYTASLREVHACCTSVPRKERQHLHDYIHMMGGTVMRDFTESVTHLIAGEVGSKKYSVACSLNKPVMLPEWVFTLWEDGKSS-HVVGTDPAY-DRFKCPIFKGCTICVTGLDAQTRQEVKQLCNQNGGVYSGELNMNTCTHLLVNQPKGEKYEFARKWNIHCVSTQWFYDCIRNGFWVEESGYRTLSSDLNSSFGSPSTKAAQAAYKSAKQRGDGELIDNNSRKGLNASRINTTAINNVNDPKTVSKLEELDLDSTLVPGSMFLDGCKLFLSGFSGPRLDKLRKIINTGGGTRFNMINEIVSHVVV 353 HSP 2 Score: 94.3597 bits (233), Expect = 1.947e-19 Identity = 62/170 (36.47%), Postives = 82/170 (48.24%), Query Frame = 3
Query: 3015 FMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGG--GAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPIS-QLGVTHFLVN 3515
F S + + Y I LGG + F+ TH++ G+P NEKYLAA+AAGKWVLHKSYL+ S +G ++ E +WG E Q N T K + L + + GAF W V L + +++EAGG VV P S GVTH VN
Sbjct: 1179 FQLSAMTPQEKADYSLLIEQLGGKVFDTMYFNPECTHVVVGKPNRNEKYLAAMAAGKWVLHKSYLEASREEGVFVREAPHEWGVEVAGE--QPNKLATAAKRWRCRLAHQRKTADPSQSLGAFTGWSVFLCVDKSRQPGFKRLLEAGGAKVVSSRPPYSCAEGVTHAFVN 1346 HSP 3 Score: 61.2326 bits (147), Expect = 2.521e-9 Identity = 53/195 (27.18%), Postives = 94/195 (48.21%), Query Frame = 3
Query: 1374 DESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGEC 1958
D+ T+ + +P F I H D + + +++ I GT++ T + + + + P K+ + ++VT ++E+CLE +++ DS FLF P I + L G VI+ S Y ER + + LGA Q++ +R + S A+THLI +P+ K+ ++K W A T +W+ C
Sbjct: 489 DDVTMADGGVGGEGLLPGKTFA--IEHFDKD---QILQLQQLIVTFGGTMVKTNDKPADFCILPMNIRPDKACAK--QMVTFCWLEKCLEVEEVVDPDSCFLFRPFVIPGGAHP--LTGCVITISQYIGVERDHMMQLAELLGAIYQEKFAR--VNSASCQASTHLICKEPEGSKYAAAKKWKKYATTCNWLFAC 672
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Nematostella
Match: EDO41864 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2Z1]) HSP 1 Score: 59.6918 bits (143), Expect = 3.625e-10 Identity = 43/168 (25.60%), Postives = 76/168 (45.24%), Query Frame = 3
Query: 3120 THLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIG---GGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEP----ISQLG--VTHFLVNKSQCSGLPDLSQ--YPCYKIEMIPSFL 3590
TH++C +P EK+L A GKW+L K YL++S + +WL+E ++W + L+ + + A W ++ G F W V ++ + K K + A G + +P + +L +TH V KS + L++ PC + IP ++
Sbjct: 5 THIVCNKPNRGEKFLCGCATGKWLLRKEYLEDSFAAQQWLDEELYEWNDACNVPGLRQDH-----------VSAPMRWRKLSEKERGPFDGWNVLVLVNDAKRRIAYKRLLAAGQARILNGKPGDTYMPKLAKKLTHVFVEKSLECDVEGLAKAGVPCLSPDYIPEYI 161
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Nematostella
Match: EDO41034 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5M3]) HSP 1 Score: 58.9214 bits (141), Expect = 1.085e-8 Identity = 96/440 (21.82%), Postives = 166/440 (37.73%), Query Frame = 3
Query: 672 MVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWN--ITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVIS-TTEGSTHYIL----PNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTI--LVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECIN 1964
MV +GGS +L +DCTHL+ G+K+ A K+ I VT WLI+SI+K + Y ++ S K+ +I S V GS A+E D +P +D L+ K VTK E + S+ + T ++ + + + R H + +NV D+ G T V +N E+ +S + A+ + + + H T + I + + GTV T TH I +FS +K +VT +++ L + + P NP+ + + + G IS +G+ +ERQL++ +GA + R THL+ ++ K+ ++ WGIP + W+ + ++
Sbjct: 123 MVTYHGGSVQLSLT-SDCTHLVIPKPIGEKYKCALKYPGLIKIVTPSWLIDSIRKDKLLPEEDYMPAEPPAPSPSVTAKNMEI-NQSPAATTDVNTQGSSANENIQCKTSPHDTIPPPTT-VDVGMTSLETKPPVVTKLVTSTAEIATSLASTQ--------ANSTPAFTTLSNQPFTMSGAETRTPMQMPRQSEGHATAAAVIETPSNVALDSTEKK-----GQTEGPPCVQSNGQET----ESHWCVFAVSD--YQDLMEHSALATWTEVIEL------HGGTVSPFYTPRCTHLICLHQCGKLFSLALKD---GKIIVTAHWLNDVLLKGSLFPP-----CNPLHLPTPFEKKLPECAGMSISVTGFTGQERQLVRNMVFMIGANYTGYLMR---------TNTHLVCRSSESLKYKKAREWGIPCINAKWLSDIVS 517
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Nematostella
Match: EDO29777 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2N6]) HSP 1 Score: 50.0618 bits (118), Expect = 2.794e-7 Identity = 37/108 (34.26%), Postives = 56/108 (51.85%), Query Frame = 3
Query: 1635 CLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGEC 1958
CLE +++ DS FLF P I + L G VI+ S Y ER + + LGA Q++ +R + S A+THLI +P+ K+ ++K W A T +W+ C
Sbjct: 1 CLEVEEVVDPDSCFLFRPFVIPGGAHP--LTGCVITISQYIGVERDHMMQLAEMLGAIYQEKFAR--VNSASCQASTHLICKEPEGSKYAAAKKWKKYATTCNWLFAC 104
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Medaka
Match: topbp1 (DNA topoisomerase II binding protein 1 [Source:NCBI gene;Acc:101166667]) HSP 1 Score: 220.705 bits (561), Expect = 6.253e-58 Identity = 227/949 (23.92%), Postives = 402/949 (42.36%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQL----SDEIHVPGSTP-----KKDSKIIMDSKCNEISVIFDGSHADE------TRLDNHDESDCV-----PDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIV----DDCTKLTEKTDGILYLKS-DWLQACLNENRLVNVHQYI--------------VDIYRP----AANVQSDNWGSMNELD------WGDTMKTVEVNNNKDESTVI---EKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVIS-TTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLL------QSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCD----QSK--------SSIKNQCSTPVRNKALDIDWKHSDMESPIYREDPNK-------PRPKLIYDENM--FKTP----EQWKKYRKPISPINTPEMRNGLA----RRIARMELDYKDKPYNKYLDETLSDTYDPTA-PKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEE 2756
+FV F + + + I P +L + +PK+ P++++A+ D+ + +S+E+ ++D+ + V++M G L +V LI+ V S+KY VA+ G P++ WV+ W S+N L + +D+Y P+L +C++G + +ER E +++ ++G + L +N+CTHLI +GQK+ A+KWN+ V+ WL +SI+KG+ D +Y + S+ STP K+D ++ + ISV GS A +RL+ D D + P + C L + + K L+ GG + + TH+++ + TK K ++ + WL + RL+ +Y+ + +P V S + N L+ + D TV N ++ E+ + + G+F F E ++ + E+ G V++ Y + + ++ ++ VVT ++ C+E+ +L L S+ LF P+++ + L G V+S S + ER+ L + +GA VQD R I K ++A+THL++ PD KF ++K WG+PAV+ HWI E ++ +L+ + DD + + Q+ N PE L + VT D QSK K+ STP +N D +H+ E+ + + P++ RP + + +TP + +K P++ + ++ LA ++ M+ K ++ DP PL GVV+ + +L + +LG WAYD TVT + + D +R E E +V+ WL AC EQ+ V E
Sbjct: 58 LFVFSSFTSPAFLHCKKHGCRIVSPLVVLYCLQQQRCVPKAEKPVYNMAMADVTISCTSLEKAARVDVMDLVQLMGGRACLDLNVSVTHLIAGEVGSKKYLVAANLGKPILLPSWVKACWEKSQN--SLFRYTDLPMDEYLCPVLLGCTVCVTGLSSTERKEVQRLCEQHGAKYSGQLKMNECTHLIVSEPAGQKYECARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERRASNTSRPHTSTPTGNGRKEDGPSLLG--LSNISV--SGSMAINDTALTISRLETADPIDGLDLTVCPADDLLDGCKLYLCGLPLKKLEKLRRLVNNAGGLRFNQPSEELTHVVMGEPDQELTKFLSKAAYRPHVVTVQWLLDSYSRGRLLPEAEYLHPDCLPPDSASVPAGHVVKPRLSAGPPVASPSTPRQNRLEEDLLSQYMDDDPTVGKNLFPQAPSLTRGPEQDSALQEFSETGLFSGKSFLFVGFGVEAEAQLSTLVIEHGGKVLAGRCRAVADYAVVPLLGCSVE--ATVDEVVTDTWLAMCVEKECVLLLSSNPLFTPVAVREGCFP--LEGCVLSVSQFIGAERESLIQLAKHVGADVQDYFVRFAIKKKGMVASTHLVLQSPDGTKFQAAKKWGLPAVSMHWILESARTGQKAAEEMFLVDLPPSPERDDESFVGGSQKPAQAR--------------NSPEIPLLGPQSGKAVTPLDLGRFQSKVFHSVLDEMKPKDGLSTPKQNP--DGSRRHAHREASLQLDTPSRFLSRDQLFRPSFNVKDALGALETPGGRLKPGEKVETPLTDVINRNLKVALANSSRNNVSEMQAASGSPELGKS-----TEKEDPQKEAGPLAGVVVCVGKKLSKMQTELNAVAASLGADFRWAYDD-TVTHYI-----YQGRVGDNSR-EYKGVKERGVHVVSQYWLQACADEQKRVPE 968 HSP 2 Score: 93.2041 bits (230), Expect = 1.452e-18 Identity = 57/176 (32.39%), Postives = 88/176 (50.00%), Query Frame = 3
Query: 3015 FMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHE-IGG-----GAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQ 3524
F S+++ Y I +LGG + F +H+I G P NEKYLAA+AAGKW+LH+SYL+ G++++E +F+WG S L P+ T + LA A+ W + + G GAF W V L + +++++GG V+P P TH + S+
Sbjct: 1218 FQMSSLSPQERIDYSHVIEDLGGVVLEKQSFDPSCSHIIVGSPLRNEKYLAAMAAGKWILHRSYLEVCRGVGRFIQEDDFEWGSSC---ILDALPSITLQQRRLA--TAAMRWRKALQGSREREGAFSGWTVMLNIDQSRESGFRRLLQSGGAKVLPGPSPSLYREATHLFADFSR 1388
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Medaka
Match: ect2 (epithelial cell transforming 2 [Source:NCBI gene;Acc:101157762]) HSP 1 Score: 79.337 bits (194), Expect = 2.242e-14 Identity = 53/220 (24.09%), Postives = 105/220 (47.73%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVND--CTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ S +L I GP + K++ + S PL+ A+ ++ +C + + ++ +L N V M G + V L++ S KYR+A G P++ W+++ W ++ V + ++ ++++P + + GF+E E+ ++ +++GG + L V D CTHL+ + S ++ + K + V EW SI+
Sbjct: 128 VFVLTDFDTSDYSFLHRRDNRIVGPPVVFHCAAKEEPMLFSCRPLYCTAMLNLSLCLTGFRNKEEMKNLVNLVHHMGGTIRKDFSTKVTHLVAYSTHGEKYRLAVCMGTPILTPLWIQKSWE-RRDDVDFHAGQEEFRSEFKVPPFQDCVLSFLGFSEEEKANMEERTLKHGGRY---LEVGDERCTHLVVEENSVRELLTSSK-KLYVVKQEWFWGSIQ 342
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Medaka
Match: ect2 (epithelial cell transforming 2 [Source:NCBI gene;Acc:101157762]) HSP 1 Score: 78.9518 bits (193), Expect = 3.014e-14 Identity = 53/220 (24.09%), Postives = 105/220 (47.73%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVND--CTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ S +L I GP + K++ + S PL+ A+ ++ +C + + ++ +L N V M G + V L++ S KYR+A G P++ W+++ W ++ V + ++ ++++P + + GF+E E+ ++ +++GG + L V D CTHL+ + S ++ + K + V EW SI+
Sbjct: 97 VFVLTDFDTSDYSFLHRRDNRIVGPPVVFHCAAKEEPMLFSCRPLYCTAMLNLSLCLTGFRNKEEMKNLVNLVHHMGGTIRKDFSTKVTHLVAYSTHGEKYRLAVCMGTPILTPLWIQKSWE-RRDDVDFHAGQEEFRSEFKVPPFQDCVLSFLGFSEEEKANMEERTLKHGGRY---LEVGDERCTHLVVEENSVRELLTSSK-KLYVVKQEWFWGSIQ 311
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Medaka
Match: ect2 (epithelial cell transforming 2 [Source:NCBI gene;Acc:101157762]) HSP 1 Score: 78.5666 bits (192), Expect = 3.074e-14 Identity = 53/220 (24.09%), Postives = 105/220 (47.73%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVND--CTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ S +L I GP + K++ + S PL+ A+ ++ +C + + ++ +L N V M G + V L++ S KYR+A G P++ W+++ W ++ V + ++ ++++P + + GF+E E+ ++ +++GG + L V D CTHL+ + S ++ + K + V EW SI+
Sbjct: 128 VFVLTDFDTSDYSFLHRRDNRIVGPPVVFHCAAKEEPMLFSCRPLYCTAMLNLSLCLTGFRNKEEMKNLVNLVHHMGGTIRKDFSTKVTHLVAYSTHGEKYRLAVCMGTPILTPLWIQKSWE-RRDDVDFHAGQEEFRSEFKVPPFQDCVLSFLGFSEEEKANMEERTLKHGGRY---LEVGDERCTHLVVEENSVRELLTSSK-KLYVVKQEWFWGSIQ 342
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Medaka
Match: ect2 (epithelial cell transforming 2 [Source:NCBI gene;Acc:101157762]) HSP 1 Score: 78.5666 bits (192), Expect = 3.437e-14 Identity = 53/220 (24.09%), Postives = 105/220 (47.73%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKI-DLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVND--CTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIK 827
+FVL F+ S +L I GP + K++ + S PL+ A+ ++ +C + + ++ +L N V M G + V L++ S KYR+A G P++ W+++ W ++ V + ++ ++++P + + GF+E E+ ++ +++GG + L V D CTHL+ + S ++ + K + V EW SI+
Sbjct: 128 VFVLTDFDTSDYSFLHRRDNRIVGPPVVFHCAAKEEPMLFSCRPLYCTAMLNLSLCLTGFRNKEEMKNLVNLVHHMGGTIRKDFSTKVTHLVAYSTHGEKYRLAVCMGTPILTPLWIQKSWE-RRDDVDFHAGQEEFRSEFKVPPFQDCVLSFLGFSEEEKANMEERTLKHGGRY---LEVGDERCTHLVVEENSVRELLTSSK-KLYVVKQEWFWGSIQ 342
BLAST of DNA topoisomerase 2 binding protein 1 vs. Planmine SMEST
Match: SMESG000021513.1 (SMESG000021513.1) HSP 1 Score: 2341.23 bits (6066), Expect = 0.000e+0 Identity = 1151/1165 (98.80%), Postives = 1156/1165 (99.23%), Query Frame = 3
Query: 177 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPSTHIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDSNISVATTTSDQSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWKHSDMESPIYREDPNKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKYLVNIDQXXXXXXXXXXXXXXXXXXNLTDRDEQPEPKKRLSLESHCENNDKVQWDYEQKSISKHELSGSFSPASEITQLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQCSGLPDLSQYPCYKIEMIPSFLSAQNDREIKRCNKKFIISAAEMQKFRK 3671
MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGV+QILIDKYQIPILHNLKICLSGFNESERDEAKQMV ENGGS+YPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLD KEEFVTKWENLIKENGGKIVSSVTMP THIIV DCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIY PAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKE CTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDP NYLLQSDDSNISVATTTSDQSNFNE CMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWK+SDMESPIYREDPNKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIARMEL+ KDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKYLVNIDQLLGLKSKPKKRKPSESLSNLTDRDEQPEPKKRLSLESHCENNDKVQWDYEQKSISKHELSGSFSPASEITQLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQCSGLPDLSQYPCYKIEMIPSFLSAQNDREIKRCNKKFI+SAAEMQKFRK
Sbjct: 1 MFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVDQILIDKYQIPILHNLKICLSGFNESERDEAKQMVNENGGSYYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDCKEEFVTKWENLIKENGGKIVSSVTMPPTHIIVGDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYSPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKEICTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPVNYLLQSDDSNISVATTTSDQSNFNETCMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKALDIDWKYSDMESPIYREDPNKPRPKLIYDENMFKTPEQWKKYRKPISPINTPEMRNGLARRIARMELENKDKPYNKYLDETLSDTYDPTAPKPLTGVVIYIFGSFQAEYLKLMRIVKNLGGPRVWAYDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKYLVNIDQLLGLKSKPKKRKPSESLSNLTDRDEQPEPKKRLSLESHCENNDKVQWDYEQKSISKHELSGSFSPASEITQLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQCSGLPDLSQYPCYKIEMIPSFLSAQNDREIKRCNKKFIVSAAEMQKFRK 1165
BLAST of DNA topoisomerase 2 binding protein 1 vs. Planmine SMEST
Match: SMESG000012344.1 (SMESG000012344.1) HSP 1 Score: 503.827 bits (1296), Expect = 2.188e-160 Identity = 285/676 (42.16%), Postives = 414/676 (61.24%), Query Frame = 3
Query: 42 VYFVQDTTTDLLKQAHDSIKAIDQVXXXXXXXXXXXXTQNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPG---------STPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVSSVTMPS----THIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYR-----PAANVQSD---NWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPN-IFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQ 2003
VYFV+DT T LL QA++++ ++ L WI+ + +L+T F K+ ++ GYFE S+ YL+S K+ FGPQCLL Y D+ LP PLFS ALK++ VCF+ EE K +L++KV MMHG VS L A+ +ILIS S+ +RKYR ASE GIPVV K+W+ ++W L++N L+G ++ I++Y+IPI HNL+I L+GF ER+ ++++I+ GG + P+L V CTHLIA ASG+KF AKKW I TV +WL++S++KGYACD +YQLS ++PG ++ ++ KII D+K N ++IW DC Q LD + EFV KW NLI E GG+ ++ S THIIV D +KL EK D I Y+ DWLQACL+ L + Q+ ++I + P +N D NW M++ + G+ + N+ + + I ++ GIF+K+ F + N + + + + I N+G + + +G+++ +L + + +P + SS +VTV+Y+ +C++ Q+L ++SDF+F + I+ N IL GT++SFSGY +ER LLK C+ GATVQDQMSRK +P K I ATTHLIISKPD KKFPSSK W IPAVTKHWIG+CI + + Y L+
Sbjct: 6 VYFVEDTKTPLLVQAYNALDGMENANLSWIKTEDILQTSTFNKHCSYIFGYFEEKSIYYLKSHKILAFGPQCLLDYLRNDETLPICEIPLFSTALKNVEVCFTGFNEEVKKELSDKVVMMHGTVSKDLNASAKILISPSIGTRKYRAASEIGIPVVSKDWINKIWELTQNTDPLDGADEYWIEQYRIPIFHNLQISLTGFPILEREIIEKIIIKCGGFYNPDLTVGICTHLIAMQASGEKFECAKKWKIITVNYQWLLDSVRKGYACDEKKYQLSGRAYIPGLSQTDSSSNNSAGQNDKIICDNKLN---------------------------TKIWKDCVIQFLDCEPEFVEKWSNLITEFGGEACKNLNDLSVVFVTHIIVGDASKLKEKEDDITYVNGDWLQACLDGKALSDSKQFDIEIPKSPIAVPISNPIPDLSINWDLMDQYNLGNVSNPFDSNSERINNENINPNSF-------GIFHKYRFFLHNLSRVQIKAVSDLIINNSGIINCSPDGASYIVLSDSLCRSPPQECSS---LVTVFYLTECVKHKQLLSIESDFMFTRMDINPN----ILTGTILSFSGYSVDERSLLKSICSAAGATVQDQMSRKPLPDKNIFATTHLIISKPDKKKFPSSKIWNIPAVTKHWIGDCIAHREMLSTDLYSLE 640 HSP 2 Score: 257.299 bits (656), Expect = 6.240e-71 Identity = 121/259 (46.72%), Postives = 177/259 (68.34%), Query Frame = 3
Query: 2892 SHCENNDKVQWDYEQKSISKHELSGSFSPASEITQLDIEKVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKT-YGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLGVTHFLVNKSQCSGLPDLSQYPCYKIEMIPSFLSAQNDREIKRCNKKFIISAAEMQKF 3665
+H K + + + ISK ++ +E+ + EK+F+ I K E ++ LGG++EL +D++ THL+ G P EKYLAAIAAGKWVLH SY+D+S++ G+W++E ++QWGG R +EF++L + K LAL DA+K +H+ GGG+F++WRVCL+E+ EK+EKM +IIE+GGGT+VP EP+ +L VTHFL+NK+ CSGLPDL+ + CY+I++IP +LSA+ND E K+ KKF I EM K
Sbjct: 654 NHGVRKRKASEEIDTRPISKRKIC----EGAELIENKSEKIFVLCTIDKASYVTLREAVKKLGGAMELGADYNGEFTHLVSGRPGRTEKYLAAIAAGKWVLHTSYIDDSMAAGRWIDEYQYQWGGLRTSEFIELESVACRFTKFDLALADAAKRFHDNGGGSFQDWRVCLVEEREKFEKMSRIIESGGGTIVPLIEPVKELHVTHFLINKNLCSGLPDLTSHSCYEIDLIPFYLSARNDCERKKFMKKFTIPVTEMDKL 908
BLAST of DNA topoisomerase 2 binding protein 1 vs. Planmine SMEST
Match: SMESG000035281.1 (SMESG000035281.1) HSP 1 Score: 169.088 bits (427), Expect = 4.855e-42 Identity = 145/561 (25.85%), Postives = 258/561 (45.99%), Query Frame = 3
Query: 42 VYFVQDTTTDLLKQAHDSIKAIDQVXXXXXXXXXXXXT-QNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIV--SSVTMPSTHIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-----THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISID 1700
+YF+ D+ + + +A+DS+ + VK + + E ++ + N FV F+ + +YL+SL+ IFGP +L +D LPK+ PLF+ LK+ + S ++ K L N +KMM G S+ ++QIL++ +V+S KY A I V+ +W+ ++W + ++ + + + +++IPI NLKICLSGF E ER+ K ++ NGG + L N+ THLI K + +K+SYA +WN+ V WL +S+K GY + ++Y+ + I+ C + +EF+ +W+ +I+ N GK+ ++ +TH I+D+ L K G Y+ WL+ +N + + + +++V + V SD + + GD + +F+ F NE +K +I I ++G +IS+ + S TH ++ + + PIK S VT ++EQ + + +P+ DF F +S D
Sbjct: 7 LYFINDSPSPMFDKAYDSLLEFEDVKAVKLSENFIMSNYEKLESNSCFVFSEFKGEAFEYLKSLERTIFGPNIILYCVSQDLSLPKTRLPLFNRKLKNYKISSSQLDVMEKQKLINLIKMMEGTYSEKFTNSIQILLTRNVESPKYSSAHNNLITVLSPDWIYDIWN---SQIENDPFNEQYLKRFKIPIFFNLKICLSGFLEPERNTIKNIINNNGGIHFGELTCNEATHLITKISKSRKYSYALQWNVKIVCINWLHDSLKDGYCKEYNKYEF--------------------------------------------------NPNIFEHCIISFIGCSDEFINQWKVIIENNNGKVSLDPNLIEKTTHFIIDNKVGLITKNYG-NYVDKSWLEKSINNGKRLPLKEFLV-LGEIPNEVSSDFYSPI----CGDIFSNCLI-----------------------MFHGF----SNEFIDKWTKI---IEMSSGGIISSKQPSQQQNPTHVVVRSSENLPIK---SQVSYVTENWLEQSIFHRKQMPV-RDFQFPLVSSD 474 HSP 2 Score: 132.494 bits (332), Expect = 8.440e-31 Identity = 152/633 (24.01%), Postives = 276/633 (43.60%), Query Frame = 3
Query: 1014 DSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVS----SVTMPSTHIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDS-NISVATTTSD----QSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKA-----LDIDWKHSDMESPIYRE----------DPNKPRPKLIYDENMFKT------PEQWKKYRKPISPI---NTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVV--------------IYIFGSFQ-AEYLKLMRIVKNLGGPRVWA-YDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
+S ++ +C + F+ KW +I G+++S S+T P THI+VDD L+ + Y+ WL+ ++ + + V ++V +D+ G +L D + + + E+ +I+ S + D + NGI +F + + S R+V ITE +G I+ ++ I+ F +++VT YYI QC+ ++IL +D DFLF P + + +LVG VIS G+ + E L+ KLGATVQD + + +K + A+T ++ ++ S W IP V + W+ EC+ R + D +L+ S+ + IS + S+ QS ++ I++PI ++ ++G V SK S S +N A ++++ +HSD +P+ +E + + L + KT P++ ++ ISPI P + R+ +++ + KDK ++ K +T V +++ FQ E KL I+ LGG + + + T ++C + +N D+ L K ++ S ++ AC RE R + E Y
Sbjct: 600 ESNMFENCLISFHGCSDGFIGKWTAIINSRSGRVISESEFSIT-PPTHIVVDDDWALSIDSR-FTYVNKSWLEQSIHAGKCLPVDIFLV----------TDSNGI--DLSIDDQSPWISESTIQQETRIID-SNSTTDGLFNGIL---VFIDQSISDYSSSRLVKIITEKSGE-ITENPSNSRLIVTGAFLAHRYKCGPESKLVTEYYISQCIANDRILDVDGDFLFYPTVVAGINPGLLLVGCVISLLGFDSYEFDELRRYSMKLGATVQDIVMKNDCRNKSLKASTVVVAKDANSNGLKSPLDWHIPVVNRDWLLECVTRKQLADYSRFLIVSNQNYMISQSAKKSELETPQSESVKVETQINNPIENDESNH-----HQNGAVITKSISKVSNVMTRSLKRKNNAHISLEIELEAEHSDPAAPLDQEMVPREIGWNYEASNDNTNLSENNIQIKTEIVEDNPKRMRRISVSISPIVISEDPITADKTLRK--QIKAEPKDKMVSEVKKAKAKIADKKPKTKEVTVAVKEVGRPVSSTSAPRLFLLTGFQDRETTKLSDIIHRLGGEVLESNLLDRPFTHLICNRLQRN--------DKFLSAVASGKWIMHSSYIEACHRESRWLNETLY 1198 HSP 3 Score: 127.872 bits (320), Expect = 2.622e-29 Identity = 71/225 (31.56%), Postives = 112/225 (49.78%), Query Frame = 3
Query: 3009 KVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLG-VTHFLVNKSQCSGLPDLS---QYPCYKIEMIPSFLSAQNDREIKRCNKKFIISAAEMQKFRK 3671
++F+ + + I LGG + ++ THLIC N+K+L+A+A+GKW++H SY++ + +WL ET ++WG S N + N L L +K W E GG AFK+WR+ LIE K E +I +GGGTV+P + + VTH +N + C+ P L +Y KI I S+L + + N +I + ++ F K
Sbjct: 1117 RLFLLTGFQDRETTKLSDIIHRLGGEVLESNLLDRPFTHLICNRLQRNDKFLSAVASGKWIMHSSYIEACHRESRWLNETLYEWGSSGTNTLIAANDRDD----LLPLALCAKRWREFGGKAFKDWRIILIESESKIESFKRIFVSGGGTVLPIGSSLPPVNEVTHSFINLN-CTNYPKLQLPFEYHWIKINFILSYL-VDDGTNLNSINSSYIYTKTQISDFNK 1335
BLAST of DNA topoisomerase 2 binding protein 1 vs. Planmine SMEST
Match: SMESG000035281.1 (SMESG000035281.1) HSP 1 Score: 168.703 bits (426), Expect = 6.613e-42 Identity = 145/561 (25.85%), Postives = 258/561 (45.99%), Query Frame = 3
Query: 42 VYFVQDTTTDLLKQAHDSIKAIDQVXXXXXXXXXXXXT-QNFGKNPMFVLGYFECSSLKYLESLKLPIFGPQCLLAYFGKDDVLPKSPYPLFSIALKDIHVCFSSIEEENKIDLTNKVKMMHGFVSDALKANVQILISSSVQSRKYRVASEKGIPVVRKEWVEELWTLSKNCVQLNGVEQILIDKYQIPILHNLKICLSGFNESERDEAKQMVIENGGSFYPNLNVNDCTHLIAKNASGQKFSYAKKWNITTVTCEWLIESIKKGYACDVDQYQLSDEIHVPGSTPKKDSKIIMDSKCNEISVIFDGSHADETRLDNHDESDCVPDSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIV--SSVTMPSTHIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGS-----THYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISID 1700
+YF+ D+ + + +A+DS+ + VK + + E ++ + N FV F+ + +YL+SL+ IFGP +L +D LPK+ PLF+ LK+ + S ++ K L N +KMM G S+ ++QIL++ +V+S KY A I V+ +W+ ++W + ++ + + + +++IPI NLKICLSGF E ER+ K ++ NGG + L N+ THLI K + +K+SYA +WN+ V WL +S+K GY + ++Y+ + I+ C + +EF+ +W+ +I+ N GK+ ++ +TH I+D+ L K G Y+ WL+ +N + + + +++V + V SD + + GD + +F+ F NE +K +I I ++G +IS+ + S TH ++ + + PIK S VT ++EQ + + +P+ DF F +S D
Sbjct: 8 LYFINDSPSPMFDKAYDSLLEFEDVKAVKLSENFIMSNYEKLESNSCFVFSEFKGEAFEYLKSLERTIFGPNIILYCVSQDLSLPKTRLPLFNRKLKNYKISSSQLDVMEKQKLINLIKMMEGTYSEKFTNSIQILLTRNVESPKYSSAHNNLITVLSPDWIYDIWN---SQIENDPFNEQYLKRFKIPIFFNLKICLSGFLEPERNTIKNIINNNGGIHFGELTCNEATHLITKISKSRKYSYALQWNVKIVCINWLHDSLKDGYCKEYNKYEF--------------------------------------------------NPNIFEHCIISFIGCSDEFINQWKVIIENNNGKVSLDPNLIEKTTHFIIDNKVGLITKNYG-NYVDKSWLEKSINNGKRLPLKEFLV-LGEIPNEVSSDFYSPI----CGDIFSNCLI-----------------------MFHGF----SNEFIDKWTKI---IEMSSGGIISSKQPSQQQNPTHVVVRSSENLPIK---SQVSYVTENWLEQSIFHRKQMPV-RDFQFPLVSSD 475 HSP 2 Score: 132.494 bits (332), Expect = 9.513e-31 Identity = 152/633 (24.01%), Postives = 276/633 (43.60%), Query Frame = 3
Query: 1014 DSRIWIDCHFQLLDYKEEFVTKWENLIKENGGKIVS----SVTMPSTHIIVDDCTKLTEKTDGILYLKSDWLQACLNENRLVNVHQYIVDIYRPAANVQSDNWGSMNELDWGDTMKTVEVNNNKDESTVIEKSTMSIDAIPNGIFYKFIFHMDNETCEKSIRIVNSITENAGTVISTTEGSTHYILPNIFSTPIKSISSSTRVVTVYYIEQCLEQNQILPLDSDFLFNPISIDSNHYNTILVGTVISFSGYPAEERQLLKETCTKLGATVQDQMSRKKIPSKRILATTHLIISKPDNKKFPSSKSWGIPAVTKHWIGECINRLKRVDPGNYLLQSDDS-NISVATTTSD----QSNFNEICMSIDHPISGNKPESILPAIEESGPVTDCDQSKSSIKNQCSTPVRNKA-----LDIDWKHSDMESPIYRE----------DPNKPRPKLIYDENMFKT------PEQWKKYRKPISPI---NTPEMRNGLARRIARMELDYKDKPYNKYLDETLSDTYDPTAPKPLTGVV--------------IYIFGSFQ-AEYLKLMRIVKNLGGPRVWA-YDSKTVTRVVCIPMAKNSYLSDENRDEILKFDEDSKVLVTSDWLLACEREQRHVEEVKY 2765
+S ++ +C + F+ KW +I G+++S S+T P THI+VDD L+ + Y+ WL+ ++ + + V ++V +D+ G +L D + + + E+ +I+ S + D + NGI +F + + S R+V ITE +G I+ ++ I+ F +++VT YYI QC+ ++IL +D DFLF P + + +LVG VIS G+ + E L+ KLGATVQD + + +K + A+T ++ ++ S W IP V + W+ EC+ R + D +L+ S+ + IS + S+ QS ++ I++PI ++ ++G V SK S S +N A ++++ +HSD +P+ +E + + L + KT P++ ++ ISPI P + R+ +++ + KDK ++ K +T V +++ FQ E KL I+ LGG + + + T ++C + +N D+ L K ++ S ++ AC RE R + E Y
Sbjct: 601 ESNMFENCLISFHGCSDGFIGKWTAIINSRSGRVISESEFSIT-PPTHIVVDDDWALSIDSR-FTYVNKSWLEQSIHAGKCLPVDIFLV----------TDSNGI--DLSIDDQSPWISESTIQQETRIID-SNSTTDGLFNGIL---VFIDQSISDYSSSRLVKIITEKSGE-ITENPSNSRLIVTGAFLAHRYKCGPESKLVTEYYISQCIANDRILDVDGDFLFYPTVVAGINPGLLLVGCVISLLGFDSYEFDELRRYSMKLGATVQDIVMKNDCRNKSLKASTVVVAKDANSNGLKSPLDWHIPVVNRDWLLECVTRKQLADYSRFLIVSNQNYMISQSAKKSELETPQSESVKVETQINNPIENDESNH-----HQNGAVITKSISKVSNVMTRSLKRKNNAHISLEIELEAEHSDPAAPLDQEMVPREIGWNYEASNDNTNLSENNIQIKTEIVEDNPKRMRRISVSISPIVISEDPITADKTLRK--QIKAEPKDKMVSEVKKAKAKIADKKPKTKEVTVAVKEVGRPVSSTSAPRLFLLTGFQDRETTKLSDIIHRLGGEVLESNLLDRPFTHLICNRLQRN--------DKFLSAVASGKWIMHSSYIEACHRESRWLNETLY 1199 HSP 3 Score: 127.487 bits (319), Expect = 3.084e-29 Identity = 71/225 (31.56%), Postives = 112/225 (49.78%), Query Frame = 3
Query: 3009 KVFMFSNIAKTLEQHYDEEIRNLGGSLELNSDFSMRMTHLICGEPCLNEKYLAAIAAGKWVLHKSYLDESISQGKWLEETEFQWGGSRKNEFLQLNPTKTYGKIFLALLDASKHWHEIGGGAFKEWRVCLIEKNEKYEKMCKIIEAGGGTVVPFSEPISQLG-VTHFLVNKSQCSGLPDLS---QYPCYKIEMIPSFLSAQNDREIKRCNKKFIISAAEMQKFRK 3671
++F+ + + I LGG + ++ THLIC N+K+L+A+A+GKW++H SY++ + +WL ET ++WG S N + N L L +K W E GG AFK+WR+ LIE K E +I +GGGTV+P + + VTH +N + C+ P L +Y KI I S+L + + N +I + ++ F K
Sbjct: 1118 RLFLLTGFQDRETTKLSDIIHRLGGEVLESNLLDRPFTHLICNRLQRNDKFLSAVASGKWIMHSSYIEACHRESRWLNETLYEWGSSGTNTLIAANDRDD----LLPLALCAKRWREFGGKAFKDWRIILIESESKIESFKRIFVSGGGTVLPIGSSLPPVNEVTHSFINLN-CTNYPKLQLPFEYHWIKINFILSYL-VDDGTNLNSINSSYIYTKTQISDFNK 1336 The following BLAST results are available for this feature:
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 4
BLAST of DNA topoisomerase 2 binding protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of DNA topoisomerase 2 binding protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028218 ID=SMED30028218|Name=DNA topoisomerase 2 binding protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=3762bpback to top protein sequence of SMED30028218-orf-1 >SMED30028218-orf-1 ID=SMED30028218-orf-1|Name=SMED30028218-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1215bp MSFTVYFVQDTTTDLLKQAHDSIKAIDQVKLIWIEEKKLLKTQNFGKNPMback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
