Tissue factor pathway inhibitor

Overview


Name	Tissue factor pathway inhibitor
Smed ID	SMED30028151
Length (bp)	404

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Tissue factor pathway inhibitor (SMED30028151) t-SNE clustered cells

Violin plots show distribution of expression levels for Tissue factor pathway inhibitor (SMED30028151) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tissue factor pathway inhibitor (SMED30028151) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tissue factor pathway inhibitor (SMED30028151) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30028151

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
head region	SMED30028151	SmedASXL_004682	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
prepharyngeal region	SMED30028151	SmedASXL_004682	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30028151	Contig47076	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30028151	Contig47076	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30028151	dd_57	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30028151	dd_Smed_v4_57_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
prepharyngeal region	SMED30028151	dd_Smed_v6_57_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: WFDC8 (WAP four-disulfide core domain 8 [Source:HGNC Symbol;Acc:HGNC:16163])

HSP 1 Score: 61.2326 bits (147), Expect = 1.188e-11
Identity = 27/67 (40.30%), Postives = 37/67 (55.22%), Query Frame = 1

Query:   73 CFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            CF  C  + +D   + C  PV  GNC     R+ +  ++ +C PFK+ GC GN NNF+NE AC   C
Sbjct:   79 CFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTAC 145

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Query:   73 CFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            CF  C  + +D   + C  PV  GNC     R+ +  ++ +C PFK+ GC GN NNF+NE AC   C
Sbjct:   79 CFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTAC 145

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BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: TFPI (tissue factor pathway inhibitor [Source:HGNC Symbol;Acc:HGNC:11760])

HSP 1 Score: 60.4622 bits (145), Expect = 3.244e-11
Identity = 26/54 (48.15%), Postives = 38/54 (70.37%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
            C  P +RG C+A+ +RF Y++  GKC PFK++GC GNENNF ++  C + C +G
Sbjct:  217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKG 270

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Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
            C  P +RG C+A+ +RF Y++  GKC PFK++GC GNENNF ++  C + C +G
Sbjct:  217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKG 270

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BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Match: SPINT3 (serine peptidase inhibitor, Kunitz type 3 [Source:HGNC Symbol;Acc:HGNC:11248])

HSP 1 Score: 53.9138 bits (128), Expect = 5.693e-10
Identity = 23/57 (40.35%), Postives = 34/57 (59.65%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            D L  +C  P+E+G C+  M R+ ++ E G+C  F + GC GN NNF+ +  C K C
Sbjct:   30 DLLPNVCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKFC 86

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BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mlt-11 (pep chromosome:WBcel235:V:20667211:20678513:1 gene:WBGene00012186.1 transcript:W01F3.3d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mlt-11)

HSP 1 Score: 57.7658 bits (138), Expect = 1.888e-10
Identity = 23/53 (43.40%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C +PVE G CK   DR+ ++ + G C PFK+ GC GN N+F  +  C   C+R
Sbjct: 1074 CLQPVEPGPCKNFADRWYFNVDDGTCHPFKYGGCAGNRNHFFTQKECEVHCAR 1126

HSP 2 Score: 50.447 bits (119), Expect = 5.768e-8
Identity = 20/53 (37.74%), Postives = 29/53 (54.72%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C  P + GNC+    R+ +  E   C  F +TGC+GN NNF ++  C  IC +
Sbjct:  728 CLHPRDSGNCRGQFVRWFFDDEKKNCDVFTYTGCQGNGNNFASKEECMAICHK 780

HSP 3 Score: 48.521 bits (114), Expect = 2.720e-7
Identity = 19/54 (35.19%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            N +C +PV +G+C+ +  R+ Y      C  F+++GC GN NNF +   C ++C
Sbjct: 2730 NPLCIQPVVKGSCQEAHLRYYYDRVTDSCRLFEYSGCDGNANNFGSLEDCQRLC 2783

HSP 4 Score: 45.4394 bits (106), Expect = 3.284e-6
Identity = 17/52 (32.69%), Postives = 28/52 (53.85%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            +C  P + G C     R+ ++++ G+C  F +  C GNENNF +   C + C
Sbjct: 2167 VCAMPPDAGVCTNYTPRWFFNSQTGQCEQFAYGSCGGNENNFFDRNTCERKC 2218

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mlt-11 (pep chromosome:WBcel235:V:20667211:20678513:1 gene:WBGene00012186.1 transcript:W01F3.3b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mlt-11)

HSP 1 Score: 57.7658 bits (138), Expect = 1.889e-10
Identity = 23/53 (43.40%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C +PVE G CK   DR+ ++ + G C PFK+ GC GN N+F  +  C   C+R
Sbjct: 1083 CLQPVEPGPCKNFADRWYFNVDDGTCHPFKYGGCAGNRNHFFTQKECEVHCAR 1135

HSP 2 Score: 52.373 bits (124), Expect = 1.088e-8
Identity = 23/61 (37.70%), Postives = 34/61 (55.74%), Query Frame = 1

Query:   97 TLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            T D +N+ C  P + GNC+    R+ +  E   C  F +TGC+GN NNF ++  C  IC +
Sbjct:  730 TTDSVNR-CLHPRDSGNCRGQFVRWFFDDEKKNCDVFTYTGCQGNGNNFASKEECMAICHK 789

HSP 3 Score: 48.521 bits (114), Expect = 2.720e-7
Identity = 19/54 (35.19%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            N +C +PV +G+C+ +  R+ Y      C  F+++GC GN NNF +   C ++C
Sbjct: 2739 NPLCIQPVVKGSCQEAHLRYYYDRVTDSCRLFEYSGCDGNANNFGSLEDCQRLC 2792

HSP 4 Score: 45.4394 bits (106), Expect = 3.284e-6
Identity = 17/52 (32.69%), Postives = 28/52 (53.85%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            +C  P + G C     R+ ++++ G+C  F +  C GNENNF +   C + C
Sbjct: 2176 VCAMPPDAGVCTNYTPRWFFNSQTGQCEQFAYGSCGGNENNFFDRNTCERKC 2227

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mlt-11 (pep chromosome:WBcel235:V:20667209:20678513:1 gene:WBGene00012186.1 transcript:W01F3.3c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mlt-11)

HSP 1 Score: 57.3806 bits (137), Expect = 2.379e-10
Identity = 23/53 (43.40%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C +PVE G CK   DR+ ++ + G C PFK+ GC GN N+F  +  C   C+R
Sbjct:  954 CLQPVEPGPCKNFADRWYFNVDDGTCHPFKYGGCAGNRNHFFTQKECEVHCAR 1006

HSP 2 Score: 52.373 bits (124), Expect = 1.344e-8
Identity = 23/61 (37.70%), Postives = 34/61 (55.74%), Query Frame = 1

Query:   97 TLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            T D +N+ C  P + GNC+    R+ +  E   C  F +TGC+GN NNF ++  C  IC +
Sbjct:  601 TTDSVNR-CLHPRDSGNCRGQFVRWFFDDEKKNCDVFTYTGCQGNGNNFASKEECMAICHK 660

HSP 3 Score: 48.521 bits (114), Expect = 3.200e-7
Identity = 19/54 (35.19%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            N +C +PV +G+C+ +  R+ Y      C  F+++GC GN NNF +   C ++C
Sbjct: 2610 NPLCIQPVVKGSCQEAHLRYYYDRVTDSCRLFEYSGCDGNANNFGSLEDCQRLC 2663

HSP 4 Score: 45.0542 bits (105), Expect = 3.863e-6
Identity = 17/52 (32.69%), Postives = 28/52 (53.85%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            +C  P + G C     R+ ++++ G+C  F +  C GNENNF +   C + C
Sbjct: 2047 VCAMPPDAGVCTNYTPRWFFNSQTGQCEQFAYGSCGGNENNFFDRNTCERKC 2098

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mlt-11 (pep chromosome:WBcel235:V:20667209:20678513:1 gene:WBGene00012186.1 transcript:W01F3.3h.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mlt-11)

HSP 1 Score: 56.6102 bits (135), Expect = 4.351e-10
Identity = 23/53 (43.40%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C +PVE G CK   DR+ ++ + G C PFK+ GC GN N+F  +  C   C+R
Sbjct:  862 CLQPVEPGPCKNFADRWYFNVDDGTCHPFKYGGCAGNRNHFFTQKECEVHCAR 914

HSP 2 Score: 51.6026 bits (122), Expect = 2.504e-8
Identity = 23/61 (37.70%), Postives = 34/61 (55.74%), Query Frame = 1

Query:   97 TLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            T D +N+ C  P + GNC+    R+ +  E   C  F +TGC+GN NNF ++  C  IC +
Sbjct:  509 TTDSVNR-CLHPRDSGNCRGQFVRWFFDDEKKNCDVFTYTGCQGNGNNFASKEECMAICHK 568

HSP 3 Score: 47.7506 bits (112), Expect = 5.356e-7
Identity = 19/54 (35.19%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            N +C +PV +G+C+ +  R+ Y      C  F+++GC GN NNF +   C ++C
Sbjct: 2137 NPLCIQPVVKGSCQEAHLRYYYDRVTDSCRLFEYSGCDGNANNFGSLEDCQRLC 2190

HSP 4 Score: 44.669 bits (104), Expect = 6.157e-6
Identity = 17/52 (32.69%), Postives = 28/52 (53.85%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            +C  P + G C     R+ ++++ G+C  F +  C GNENNF +   C + C
Sbjct: 1574 VCAMPPDAGVCTNYTPRWFFNSQTGQCEQFAYGSCGGNENNFFDRNTCERKC 1625

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Match: mlt-11 (pep chromosome:WBcel235:V:20667211:20678513:1 gene:WBGene00012186.1 transcript:W01F3.3e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mlt-11)

HSP 1 Score: 56.225 bits (134), Expect = 5.762e-10
Identity = 23/53 (43.40%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C +PVE G CK   DR+ ++ + G C PFK+ GC GN N+F  +  C   C+R
Sbjct: 1083 CLQPVEPGPCKNFADRWYFNVDDGTCHPFKYGGCAGNRNHFFTQKECEVHCAR 1135

HSP 2 Score: 51.2174 bits (121), Expect = 3.189e-8
Identity = 23/61 (37.70%), Postives = 34/61 (55.74%), Query Frame = 1

Query:   97 TLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            T D +N+ C  P + GNC+    R+ +  E   C  F +TGC+GN NNF ++  C  IC +
Sbjct:  730 TTDSVNR-CLHPRDSGNCRGQFVRWFFDDEKKNCDVFTYTGCQGNGNNFASKEECMAICHK 789

HSP 3 Score: 47.3654 bits (111), Expect = 6.819e-7
Identity = 19/54 (35.19%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            N +C +PV +G+C+ +  R+ Y      C  F+++GC GN NNF +   C ++C
Sbjct: 2213 NPLCIQPVVKGSCQEAHLRYYYDRVTDSCRLFEYSGCDGNANNFGSLEDCQRLC 2266

HSP 4 Score: 44.2838 bits (103), Expect = 7.686e-6
Identity = 17/52 (32.69%), Postives = 28/52 (53.85%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            +C  P + G C     R+ ++++ G+C  F +  C GNENNF +   C + C
Sbjct: 1650 VCAMPPDAGVCTNYTPRWFFNSQTGQCEQFAYGSCGGNENNFFDRNTCERKC 1701

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BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: CG13748 (gene:FBgn0033355 transcript:FBtr0088656)

HSP 1 Score: 54.299 bits (129), Expect = 3.806e-10
Identity = 23/55 (41.82%), Postives = 30/55 (54.55%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
             + C  P  +G C+A + R+ Y  E  KC+ FKF GC GNENNF +   C   C 
Sbjct:   57 EQFCLMPARKGVCRALIPRWRYDPEQKKCVEFKFGGCDGNENNFASYKDCMSTCE 111

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BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: Ppn (gene:FBgn0003137 transcript:FBtr0301837)

HSP 1 Score: 53.9138 bits (128), Expect = 5.254e-9
Identity = 23/54 (42.59%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
             C +PVE G C  + +R+ Y  E   C PF + GC+GN+NN+  E ACN  C +
Sbjct: 1729 TCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQ 1782

HSP 2 Score: 48.1358 bits (113), Expect = 4.382e-7
Identity = 20/59 (33.90%), Postives = 32/59 (54.24%), Query Frame = 1

Query:  109 LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            L   C  P + G+C   + ++ +S    +C+PF ++GC GN+NNF    +C   C R V
Sbjct: 1786 LKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTLESCEDHCPRQV 1844

HSP 3 Score: 46.9802 bits (110), Expect = 1.032e-6
Identity = 21/52 (40.38%), Postives = 29/52 (55.77%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
             C  P  RG C     R+ +    G+C  F+FTGCRGN NNF++++ C   C
Sbjct: 2127 TCALPPVRGRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQSDCLNFC 2178

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: Ppn (gene:FBgn0003137 transcript:FBtr0300337)

HSP 1 Score: 53.5286 bits (127), Expect = 5.572e-9
Identity = 23/54 (42.59%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
             C +PVE G C  + +R+ Y  E   C PF + GC+GN+NN+  E ACN  C +
Sbjct: 1729 TCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQ 1782

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: Acp24A4 (gene:FBgn0051779 transcript:FBtr0305673)

HSP 1 Score: 49.6766 bits (117), Expect = 9.363e-9
Identity = 25/69 (36.23%), Postives = 37/69 (53.62%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVE-RGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAAC 261
            L+L   F+     +L   N+IC  P    GNC A   R+SY  ++  C  F + GC+GNEN+F ++  C
Sbjct:    4 LILLFVFIALASNSLALKNEICGLPAAANGNCLALFSRWSYDAQYNVCFNFIYGGCQGNENSFESQEEC 72

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Match: Acp24A4 (gene:FBgn0051779 transcript:FBtr0110767)

HSP 1 Score: 49.6766 bits (117), Expect = 9.363e-9
Identity = 25/69 (36.23%), Postives = 37/69 (53.62%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVE-RGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAAC 261
            L+L   F+     +L   N+IC  P    GNC A   R+SY  ++  C  F + GC+GNEN+F ++  C
Sbjct:    4 LILLFVFIALASNSLALKNEICGLPAAANGNCLALFSRWSYDAQYNVCFNFIYGGCQGNENSFESQEEC 72

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: aplp2 (amyloid beta (A4) precursor-like protein 2 [Source:ZFIN;Acc:ZDB-GENE-061009-28])

HSP 1 Score: 59.6918 bits (143), Expect = 4.972e-11
Identity = 24/62 (38.71%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   94 QTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +TL  +  +C+   E G C+ASM R+ +  +  KC+ F + GC GN NNF +E  C  +C R
Sbjct:  306 KTLQEVEAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMVVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: aplp2 (amyloid beta (A4) precursor-like protein 2 [Source:ZFIN;Acc:ZDB-GENE-061009-28])

HSP 1 Score: 59.6918 bits (143), Expect = 4.980e-11
Identity = 24/62 (38.71%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   94 QTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +TL  +  +C+   E G C+ASM R+ +  +  KC+ F + GC GN NNF +E  C  +C R
Sbjct:  306 KTLQEVEAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMVVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 58.151 bits (139), Expect = 1.673e-10
Identity = 23/61 (37.70%), Postives = 32/61 (52.46%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            + +  +C  P   G C A + R+ +  E G+C  F F GC GN NNF +E  C  +CS  V
Sbjct:  300 EVVRAVCWAPARSGPCHAKLPRWYFVAEKGRCASFTFGGCGGNRNNFESEEYCMAVCSSSV 360

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 58.151 bits (139), Expect = 1.674e-10
Identity = 23/61 (37.70%), Postives = 32/61 (52.46%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            + +  +C  P   G C A + R+ +  E G+C  F F GC GN NNF +E  C  +CS  V
Sbjct:  288 EVVRAVCWAPARSGPCHAKLPRWYFVAEKGRCASFTFGGCGGNRNNFESEEYCMAVCSSSV 348

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Match: appb (amyloid beta (A4) precursor protein b [Source:ZFIN;Acc:ZDB-GENE-020220-1])

HSP 1 Score: 58.151 bits (139), Expect = 1.674e-10
Identity = 23/61 (37.70%), Postives = 32/61 (52.46%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            + +  +C  P   G C A + R+ +  E G+C  F F GC GN NNF +E  C  +CS  V
Sbjct:  289 EVVRAVCWAPARSGPCHAKLPRWYFVAEKGRCASFTFGGCGGNRNNFESEEYCMAVCSSSV 349

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: cmtr2 (cap methyltransferase 2 [Source:Xenbase;Acc:XB-GENE-6035233])

HSP 1 Score: 47.7506 bits (112), Expect = 6.193e-8
Identity = 20/57 (35.09%), Postives = 30/57 (52.63%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
            +  C  P+  G CKA+   +++    GKC+ F + GC+GN N F  E  C +  S G
Sbjct:    3 HAACRLPITPGPCKAAKTHWAFDAAQGKCVTFAYGGCQGNGNQFYTEKECKEYSSIG 59

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:NCBI gene;Acc:548483])

HSP 1 Score: 50.0618 bits (118), Expect = 9.180e-8
Identity = 21/55 (38.18%), Postives = 32/55 (58.18%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
             C  P + G+C AS+ R+ ++ E   C  F +TGC GN NNF+    C+ +C +G
Sbjct:  148 FCYSPKDEGSCSASVTRYYFNIESKACEEFVYTGCGGNSNNFVKMEDCDSVCKKG 202

HSP 2 Score: 45.8246 bits (107), Expect = 3.113e-6
Identity = 20/56 (35.71%), Postives = 33/56 (58.93%), Query Frame = 1

Query:  109 LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            + K C    + G C+  + R++Y+ +  KC  F + GC GN+NNF ++A+C   CS
Sbjct:   85 VPKACRMDPDEGPCRGFLKRYAYNMQTMKCEQFYYGGCYGNDNNFKDKASCMDFCS 140

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: rlbp1 (retinaldehyde binding protein 1 [Source:Xenbase;Acc:XB-GENE-976303])

HSP 1 Score: 50.0618 bits (118), Expect = 1.523e-7
Identity = 24/58 (41.38%), Postives = 31/58 (53.45%), Query Frame = 1

Query:  100 LDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            L C N  C    + G C+AS  RF Y     KC+ F + GC GN+NNF  E+ C + C
Sbjct:  351 LFCENSRCVDLPDTGPCRASFSRFYYDPNIRKCLRFTYGGCAGNDNNFHRESDCMRYC 408

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: cmtr2 (cap methyltransferase 2 [Source:Xenbase;Acc:XB-GENE-6035233])

HSP 1 Score: 46.2098 bits (108), Expect = 2.087e-7
Identity = 18/55 (32.73%), Postives = 29/55 (52.73%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            +  C  P+  G CKA+   +++    GKC+ F + GC+GN N F  E  C +  +
Sbjct:    3 HAACRLPITPGPCKAAKTHWAFDAAQGKCVTFAYGGCQGNGNQFYTEKECKEYWA 57

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Match: APLP2 (amyloid beta (A4) precursor-like protein 2 [Source:NCBI gene;Acc:100380132])

HSP 1 Score: 49.6766 bits (117), Expect = 2.189e-7
Identity = 19/55 (34.55%), Postives = 30/55 (54.55%), Query Frame = 1

Query:  109 LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            +  +C++    G C+A M R+ +     KC+ F + GC GN NNF +E  C  +C
Sbjct:  271 VKSVCSQEAMTGPCRAMMPRWYFDLGQKKCVRFIYGGCGGNRNNFESEDYCMAVC 325

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: Spint3 (serine peptidase inhibitor, Kunitz type, 3 [Source:MGI Symbol;Acc:MGI:3651470])

HSP 1 Score: 53.9138 bits (128), Expect = 4.028e-10
Identity = 22/56 (39.29%), Postives = 36/56 (64.29%), Query Frame = 1

Query:  109 LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            L  +C  P + G C+A   R+ Y+++ GKC  F++ GC+GNENNF + + C  +C+
Sbjct:   31 LPPMCILPKDIGGCRAVFVRWYYNSKTGKCEWFRYGGCKGNENNFPSRSQCQAVCT 86

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: Wfdc6b (WAP four-disulfide core domain 6B [Source:MGI Symbol;Acc:MGI:3575430])

HSP 1 Score: 53.9138 bits (128), Expect = 1.422e-9
Identity = 26/67 (38.81%), Postives = 37/67 (55.22%), Query Frame = 1

Query:   73 CFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            C   C  + LD    IC+ P + G C A + R+ Y+ +   CI F + GC+GN NNF ++A C  IC
Sbjct:   72 CLFACGRKCLDLSEDICSLPQDAGPCLAYLPRWWYNQDTKLCIEFIYGGCQGNPNNFESKAVCTSIC 138

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: Wfdc6a (WAP four-disulfide core domain 6A [Source:MGI Symbol;Acc:MGI:2684968])

HSP 1 Score: 51.6026 bits (122), Expect = 6.642e-9
Identity = 23/69 (33.33%), Postives = 36/69 (52.17%), Query Frame = 1

Query:   73 CFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C   C  + +D    +C+ P + G C A + R+ Y+ E   C  F + GC+GN NNF +E  C  +C +
Sbjct:   61 CLFSCGKKCMDLRQDVCSLPQDPGPCLAYLPRWWYNQETDLCTEFIYGGCQGNPNNFPSEGICTVVCKK 129

[Close]

Query:   73 CFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C   C  + +D    +C+ P + G C A + R+ Y+ E   C  F + GC+GN NNF +E  C  +C +
Sbjct:   61 CLFSCGKKCMDLRQDVCSLPQDPGPCLAYLPRWWYNQETDLCTEFIYGGCQGNPNNFPSEGICTVVCKK 129

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Match: App (amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059])

HSP 1 Score: 53.5286 bits (127), Expect = 7.363e-9
Identity = 20/46 (43.48%), Postives = 27/46 (58.70%), Query Frame = 1

Query:  136 ERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            E G C+A + R+ +    GKC+PF + GC GN NNF  E  C  +C
Sbjct:  296 ETGPCRAMISRWYFDVTEGKCVPFFYGGCGGNRNNFDTEEYCMAVC 341

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P0DN12|VKT8_ANEVI (U-actitoxin-Avd3k OS=Anemonia viridis OX=51769 PE=3 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 4.379e-11
Identity = 27/72 (37.50%), Postives = 41/72 (56.94%), Query Frame = 1

Query:   70 ICFVICFIQTLDC---LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            + F++CF    D    +NK C  P++ G C+A   R+ Y++   +C  F + GCRGN NNFI +  C K+C 
Sbjct:    1 MVFLLCFFLVADVSYGINKDCLLPMDVGRCRARHPRYYYNSSSKRCEKFIYGGCRGNANNFITKKECEKVCG 72

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P0DN20|VKTG_ANEVI (U-actitoxin-Avd3s (Fragment) OS=Anemonia viridis OX=51769 PE=2 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 4.694e-11
Identity = 27/70 (38.57%), Postives = 40/70 (57.14%), Query Frame = 1

Query:   76 FVICFIQTLDC---LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            F++CF    D    +NK C  P++ G C+A   R+ Y++   +C  F + GCRGN NNFI +  C K+C 
Sbjct:    1 FLLCFFLVADVSYGINKDCLLPMDVGRCRARHPRYYYNSSSKRCEMFNYGGCRGNANNFITKKECEKVCG 70

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|Q8IUA0|WFDC8_HUMAN (WAP four-disulfide core domain protein 8 OS=Homo sapiens OX=9606 GN=WFDC8 PE=2 SV=2)

HSP 1 Score: 61.2326 bits (147), Expect = 5.706e-11
Identity = 27/67 (40.30%), Postives = 37/67 (55.22%), Query Frame = 1

Query:   73 CFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            CF  C  + +D   + C  PV  GNC     R+ +  ++ +C PFK+ GC GN NNF+NE AC   C
Sbjct:   79 CFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTAC 145

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|P10646|TFPI1_HUMAN (Tissue factor pathway inhibitor OS=Homo sapiens OX=9606 GN=TFPI PE=1 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 1.558e-10
Identity = 26/54 (48.15%), Postives = 38/54 (70.37%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
            C  P +RG C+A+ +RF Y++  GKC PFK++GC GNENNF ++  C + C +G
Sbjct:  217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKG 270

[Close]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Match: sp|Q28864|TFPI1_MACMU (Tissue factor pathway inhibitor OS=Macaca mulatta OX=9544 GN=TFPI PE=2 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 1.653e-10
Identity = 26/54 (48.15%), Postives = 38/54 (70.37%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
            C  P +RG C+A+ +RF Y++  GKC PFK++GC GNENNF ++  C + C +G
Sbjct:  217 CLAPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKRECLRACKKG 270

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A0N4VWW6 (BPTI/Kunitz inhibitor domain-containing protein OS=Haemonchus placei OX=6290 GN=HPLM_LOCUS1784 PE=4 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 1.646e-12
Identity = 31/74 (41.89%), Postives = 44/74 (59.46%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +++A+  +   + T   L+ IC   +E G C+A+  RF YST   KCI F + GCRGN+NNF  E  C + CSR
Sbjct:    1 MMIAVVVLFTLLTTASALDDICKLDLEVGPCRAAFRRFGYSTTENKCITFIYGGCRGNDNNFETEEECKQKCSR 74

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A5K3F6A2 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 66.2402 bits (160), Expect = 1.064e-11
Identity = 30/71 (42.25%), Postives = 41/71 (57.75%), Query Frame = 1

Query:   61 VLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            VLA+   IC     + +   C  P+ERG C A M R++Y    G C+PF + GC GN N F ++AAC K+C
Sbjct:    4 VLAL-VAICLASFTEAITSPCYLPIERGMCMAHMKRWAYDATTGLCVPFVYGGCGGNANQFKSKAACRKVC 73

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A2K5RB57 (Serine peptidase inhibitor, Kunitz type 3 OS=Cebus capucinus imitator OX=1737458 GN=SPINT3 PE=4 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 2.565e-11
Identity = 28/57 (49.12%), Postives = 41/57 (71.93%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            D L K+CT P+E+G C+A  +R+ +++E G+C  F + GCRGN+NNF N+  C KIC
Sbjct:   30 DLLPKVCTFPMEKGVCRAYFNRWFFNSEAGECESFVYGGCRGNDNNFANKEECEKIC 86

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A3S2LXI9 (BPTI/Kunitz inhibitor domain-containing protein OS=Chilo suppressalis OX=168631 GN=evm_008805 PE=4 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 2.929e-11
Identity = 29/70 (41.43%), Postives = 40/70 (57.14%), Query Frame = 1

Query:   70 ICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            + F++ F+     L K C +P+ERG C A   RF Y+ E  KC  F + GC+GN+N FI    C K+C R
Sbjct:    5 LIFLLAFVAVASALEKRCEEPIERGLCYAYFPRFGYNKEINKCEFFVYGGCQGNDNRFITAEECEKVCQR 74

[Close]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Match: A0A0F7Z579 (Tissue factor pathway inhibitor OS=Crotalus adamanteus OX=8729 PE=2 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 3.551e-11
Identity = 34/73 (46.58%), Postives = 44/73 (60.27%), Query Frame = 1

Query:   64 LAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRG 282
            L  C   C  + L  L  +C  P++RG CKA+  RF Y+   GKC PF +TGC GNENNF +  AC K+C +G
Sbjct:  167 LQECQNTCHDRDLFLLPSLCVMPMDRGLCKANEKRFFYNQTTGKCRPFSYTGCGGNENNFTSRKACVKMCKKG 239

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: appb (amyloid beta A4 protein-like [Source:NCBI gene;Acc:103046668])

HSP 1 Score: 65.4698 bits (158), Expect = 4.005e-13
Identity = 25/61 (40.98%), Postives = 36/61 (59.02%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            + +  +C  P  RG C+A++ R+ +  E G+C PF F GC GN NNF +E  C  +CS  V
Sbjct:  305 EVVRAVCWAPPRRGPCRATLSRWYFVAETGRCAPFSFGGCGGNRNNFESEEYCMAVCSSSV 365

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: appb (amyloid beta A4 protein-like [Source:NCBI gene;Acc:103046668])

HSP 1 Score: 65.4698 bits (158), Expect = 4.020e-13
Identity = 25/61 (40.98%), Postives = 36/61 (59.02%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            + +  +C  P  RG C+A++ R+ +  E G+C PF F GC GN NNF +E  C  +CS  V
Sbjct:  305 EVVRAVCWAPPRRGPCRATLSRWYFVAETGRCAPFSFGGCGGNRNNFESEEYCMAVCSSSV 365

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:103022515])

HSP 1 Score: 60.4622 bits (145), Expect = 2.449e-11
Identity = 24/62 (38.71%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   94 QTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +TL  +  +C+   E G C+ASM R+ +  +  KC+ F + GC GN NNF +E  C  +C R
Sbjct:  306 KTLQEVKAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:103022515])

HSP 1 Score: 60.4622 bits (145), Expect = 2.454e-11
Identity = 24/62 (38.71%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   94 QTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +TL  +  +C+   E G C+ASM R+ +  +  KC+ F + GC GN NNF +E  C  +C R
Sbjct:  306 KTLQEVKAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:103022515])

HSP 1 Score: 60.4622 bits (145), Expect = 2.458e-11
Identity = 24/62 (38.71%), Postives = 36/62 (58.06%), Query Frame = 1

Query:   94 QTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +TL  +  +C+   E G C+ASM R+ +  +  KC+ F + GC GN NNF +E  C  +C R
Sbjct:  306 KTLQEVKAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 367

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008261.1 (pep scaffold:Pmarinus_7.0:GL478901:735:1448:1 gene:ENSPMAG00000007479.1 transcript:ENSPMAT00000008261.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.1358 bits (113), Expect = 6.480e-8
Identity = 20/53 (37.74%), Postives = 32/53 (60.38%), Query Frame = 1

Query:  115 KICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            ++C+ P  +G CKA   R+SY+    +C  F + GC GN N+F + +AC + C
Sbjct:   19 RVCSLPPVQGPCKAWETRWSYNPLGKRCATFLYGGCEGNGNSFASRSACERAC 71

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:ZFIN;Acc:ZDB-GENE-060503-38])

HSP 1 Score: 47.7506 bits (112), Expect = 1.115e-7
Identity = 20/53 (37.74%), Postives = 30/53 (56.60%), Query Frame = 1

Query:  115 KICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            + C    + GNC+ +  RF Y+ +   C+PF ++GC GN NNFI+   C   C
Sbjct:  145 RECLSRHDTGNCQGNFRRFYYNIQKRSCLPFSYSGCGGNNNNFISAKTCLSTC 197

HSP 2 Score: 44.669 bits (104), Expect = 1.152e-6
Identity = 19/51 (37.25%), Postives = 29/51 (56.86%), Query Frame = 1

Query:  109 LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAAC 261
            + K+C    E G C+A + R+ Y+   G C+PF + GC GN N F +  +C
Sbjct:   83 IPKLCRPDAETGRCRAHITRYFYNMTLGMCMPFVYGGCGGNNNRFEDMESC 133

HSP 3 Score: 43.5134 bits (101), Expect = 3.468e-6
Identity = 21/60 (35.00%), Postives = 31/60 (51.67%), Query Frame = 1

Query:   97 TLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            TL+     CT P + G+C+A+  R+ ++    +C  F + GC  NENNF     C   CS
Sbjct:   19 TLEDQRVTCTLPAKPGDCRAAFPRYFFNRSTLRCESFIYGGCHSNENNFETMQECRAACS 78

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005043.1 (pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 gene:ENSPMAG00000004579.1 transcript:ENSPMAT00000005043.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.9802 bits (110), Expect = 1.874e-7
Identity = 21/57 (36.84%), Postives = 32/57 (56.14%), Query Frame = 1

Query:  109 LNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            L +IC    + G C A + RF Y+ +   C  F + GC GN+NNF +E +C  +C +
Sbjct:  162 LPRICLMKADPGECTAVIPRFHYNPKTSNCESFTYGGCGGNDNNFSSERSCMSVCGQ 218

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30912])

HSP 1 Score: 47.3654 bits (111), Expect = 1.912e-7
Identity = 23/68 (33.82%), Postives = 37/68 (54.41%), Query Frame = 1

Query:   70 ICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            I +  C +  +  +N  C+ PV++G CK    R++Y+    +C  F + GC GNENNF ++  C   C
Sbjct:  357 ITYEECKMACMANINNTCSLPVQQGPCKQWALRWAYNPLIKRCQSFIYGGCEGNENNFQSQELCEDNC 424

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009465.1 (pep scaffold:Pmarinus_7.0:GL478507:22936:25713:-1 gene:ENSPMAG00000008558.1 transcript:ENSPMAT00000009465.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.9802 bits (110), Expect = 2.112e-7
Identity = 20/46 (43.48%), Postives = 26/46 (56.52%), Query Frame = 1

Query:  142 GNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            G C+ S  R++Y      C  F + GCRGN+NNF+ EA C   C R
Sbjct:    8 GPCRGSFTRWTYDAATSTCKEFTYGGCRGNQNNFLEEAECLMDCGR 53

HSP 2 Score: 45.4394 bits (106), Expect = 7.496e-7
Identity = 22/57 (38.60%), Postives = 29/57 (50.88%), Query Frame = 1

Query:  106 CLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            CL +  T P     C+ S  R++Y  E G C  F + GC GN NNF+ E  C  +C 
Sbjct:  166 CLLEAVTSP-----CRGSFTRWTYDAESGHCKEFTYGGCGGNFNNFLEETECVAMCG 217

HSP 3 Score: 42.743 bits (99), Expect = 5.477e-6
Identity = 21/56 (37.50%), Postives = 26/56 (46.43%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            IC      G C+ S  R+ Y  E   C  F + GC GN NNF+ E  C   C R +
Sbjct:   71 ICLLEEAVGPCRGSFTRWIYDAESSNCKEFTYGGCGGNFNNFLEETECMVTCGRSL 126

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO40368 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7B9])

HSP 1 Score: 50.8322 bits (120), Expect = 7.819e-10
Identity = 23/44 (52.27%), Postives = 28/44 (63.64%), Query Frame = 1

Query:  142 GNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            G+C     R+ Y T  GKC PF +TGC GNENNF+NE  C + C
Sbjct:    8 GSCSRFTVRWFYDTNRGKCAPFVYTGCGGNENNFMNEQKCLETC 51

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO31760 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX09])

HSP 1 Score: 50.0618 bits (118), Expect = 1.683e-9
Identity = 24/53 (45.28%), Postives = 31/53 (58.49%), Query Frame = 1

Query:  121 CTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            C  P   G C+AS+ R+ Y+ E  KCI F F GC GN NNF  +++C   C R
Sbjct:    1 CDLPKNPGVCRASIQRWYYNNETRKCIKFTFGGCHGNANNFPTKSSCRNACMR 53

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO29819 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2J6])

HSP 1 Score: 48.9062 bits (115), Expect = 5.531e-9
Identity = 23/54 (42.59%), Postives = 32/54 (59.26%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            N  CT P + G+C+A+M R  ++++ GKC  F + GC GN NNF     C K C
Sbjct:   11 NSACTLPKKVGDCRAAMPRVFFNSQSGKCEDFIYGGCGGNANNFHTMEECKKAC 64

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO26072 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TCY8])

HSP 1 Score: 46.595 bits (109), Expect = 5.271e-8
Identity = 22/55 (40.00%), Postives = 31/55 (56.36%), Query Frame = 1

Query:  112 NKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
             ++C+ P   G C A   R+ Y     +C  F + GC+GN NNF ++AAC K CS
Sbjct:   12 TQVCSLPKLTGPCMARFIRWHYDMRSSECKMFTYGGCQGNANNFESKAACLKKCS 66

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Match: EDO38466 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCV3])

HSP 1 Score: 46.2098 bits (108), Expect = 5.800e-8
Identity = 22/54 (40.74%), Postives = 31/54 (57.41%), Query Frame = 1

Query:  115 KICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            ++C+ P   G C A   R+ Y     +C  F + GC+GN NNF ++AAC K CS
Sbjct:   13 QVCSLPKLTGPCMARFIRWHYDMRSSECKMFTYGGCQGNANNFESKAACLKKCS 66

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:101168561])

HSP 1 Score: 58.5362 bits (140), Expect = 1.307e-10
Identity = 23/54 (42.59%), Postives = 31/54 (57.41%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +CT   E G C+ASM R+ +     KC+ F + GC GN NNF +E  C  +C R
Sbjct:  313 VCTLEAETGPCRASMPRWHFDLSQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 366

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:101168561])

HSP 1 Score: 58.5362 bits (140), Expect = 1.310e-10
Identity = 23/54 (42.59%), Postives = 31/54 (57.41%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +CT   E G C+ASM R+ +     KC+ F + GC GN NNF +E  C  +C R
Sbjct:  313 VCTLEAETGPCRASMPRWHFDLSQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 366

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: aplp2 (amyloid beta precursor like protein 2 [Source:NCBI gene;Acc:101168561])

HSP 1 Score: 58.5362 bits (140), Expect = 1.312e-10
Identity = 23/54 (42.59%), Postives = 31/54 (57.41%), Query Frame = 1

Query:  118 ICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            +CT   E G C+ASM R+ +     KC+ F + GC GN NNF +E  C  +C R
Sbjct:  313 VCTLEAETGPCRASMPRWHFDLSQRKCVRFIYGGCAGNRNNFDSEEYCMAVCKR 366

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: appb (amyloid-beta A4 protein [Source:NCBI gene;Acc:101172288])

HSP 1 Score: 56.6102 bits (135), Expect = 6.302e-10
Identity = 22/58 (37.93%), Postives = 31/58 (53.45%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            + +  +C    E G C   ++R+ +  E G+C PF F GC GN NNF  E  C  +CS
Sbjct:  280 EVVRAVCWARAESGPCHGMLERWYFEPESGRCAPFLFGGCGGNRNNFETEEYCLAVCS 337

[Close]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Match: APP (amyloid-beta A4 protein [Source:NCBI gene;Acc:101162104])

HSP 1 Score: 55.4546 bits (132), Expect = 1.617e-9
Identity = 21/58 (36.21%), Postives = 33/58 (56.90%), Query Frame = 1

Query:  103 DCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICS 276
            + +  +C    E G C+A + R+ +  E G+C+ F + GC GN NNF +E  C  +CS
Sbjct:  324 EVVRDVCWADAETGPCRALLPRWFFDREEGRCVQFIYGGCGGNRNNFESEEYCMSVCS 381

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000044323.1 (SMESG000044323.1)

HSP 1 Score: 156.762 bits (395), Expect = 6.210e-51
Identity = 76/76 (100.00%), Postives = 76/76 (100.00%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 285
            LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV
Sbjct:    3 LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSRGV 78

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000037999.1 (SMESG000037999.1)

HSP 1 Score: 53.1434 bits (126), Expect = 3.535e-10
Identity = 28/72 (38.89%), Postives = 40/72 (55.56%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            LVL + F +   Q L+   K C +P + G C+A   RF +++E GKC  F + GC  N NNF  E  C ++C
Sbjct:    8 LVLVVLFSLS--QLLESRLKECNEPKQSGMCEAYFKRFYFNSETGKCETFIYGGCGKNGNNFQTEDECEELC 77

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000037999.1 (SMESG000037999.1)

HSP 1 Score: 52.7582 bits (125), Expect = 3.960e-10
Identity = 28/72 (38.89%), Postives = 40/72 (55.56%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            LVL + F +   Q L+   K C +P + G C+A   RF +++E GKC  F + GC  N NNF  E  C ++C
Sbjct:    6 LVLVVLFSLS--QLLESRLKECNEPKQSGMCEAYFKRFYFNSETGKCETFIYGGCGKNGNNFQTEDECEELC 75

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000005324.1 (SMESG000005324.1)

HSP 1 Score: 52.7582 bits (125), Expect = 4.771e-10
Identity = 27/68 (39.71%), Postives = 42/68 (61.76%), Query Frame = 1

Query:   79 VICFIQTLD-CLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKICSR 279
            VI  I+  D  L+K+C +P++ G CK ++ R  ++ + GKC  F + GC+GN+NNF   + C K C R
Sbjct:   12 VIFLIEGKDFLLDKLCFQPMDPGPCKGNLVRSYFNKDIGKCEIFSYGGCKGNKNNFPRISDCQKKCMR 79

[Close]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Match: SMESG000037995.1 (SMESG000037995.1)

HSP 1 Score: 51.9878 bits (123), Expect = 8.321e-10
Identity = 28/72 (38.89%), Postives = 39/72 (54.17%), Query Frame = 1

Query:   58 LVLAICFVICFIQTLDCLNKICTKPVERGNCKASMDRFSYSTEHGKCIPFKFTGCRGNENNFINEAACNKIC 273
            LVL + F +   Q L+   K C +P + G C A   RF +++E GKC  F + GC  N NNF  E  C ++C
Sbjct:    8 LVLVVLFSLS--QLLESRLKECNEPKQSGMCMAYFKRFYFNSETGKCETFIYGGCGKNGNNFQTEDECEELC 77

The following BLAST results are available for this feature:

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
BLAST of Tissue factor pathway inhibitor vs. TrEMBL
BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
BLAST of Tissue factor pathway inhibitor vs. Ensembl Yeast
BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST

BLAST of Tissue factor pathway inhibitor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
WFDC8	1.188e-11	40.30	WAP four-disulfide core domain 8 [Source:HGNC Symb...	[more]
WFDC8	1.188e-11	40.30	WAP four-disulfide core domain 8 [Source:HGNC Symb...	[more]
TFPI	3.244e-11	48.15	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
TFPI	3.244e-11	48.15	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
SPINT3	5.693e-10	40.35	serine peptidase inhibitor, Kunitz type 3 [Source:...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mlt-11	1.888e-10	43.40	pep chromosome:WBcel235:V:20667211:20678513:1 gene...	[more]
mlt-11	1.889e-10	43.40	pep chromosome:WBcel235:V:20667211:20678513:1 gene...	[more]
mlt-11	2.379e-10	43.40	pep chromosome:WBcel235:V:20667209:20678513:1 gene...	[more]
mlt-11	4.351e-10	43.40	pep chromosome:WBcel235:V:20667209:20678513:1 gene...	[more]
mlt-11	5.762e-10	43.40	pep chromosome:WBcel235:V:20667211:20678513:1 gene...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG13748	3.806e-10	41.82	gene:FBgn0033355 transcript:FBtr0088656	[more]
Ppn	5.254e-9	42.59	gene:FBgn0003137 transcript:FBtr0301837	[more]
Ppn	5.572e-9	42.59	gene:FBgn0003137 transcript:FBtr0300337	[more]
Acp24A4	9.363e-9	36.23	gene:FBgn0051779 transcript:FBtr0305673	[more]
Acp24A4	9.363e-9	36.23	gene:FBgn0051779 transcript:FBtr0110767	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
aplp2	4.972e-11	38.71	amyloid beta (A4) precursor-like protein 2 [Source...	[more]
aplp2	4.980e-11	38.71	amyloid beta (A4) precursor-like protein 2 [Source...	[more]
appb	1.673e-10	37.70	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]
appb	1.674e-10	37.70	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]
appb	1.674e-10	37.70	amyloid beta (A4) precursor protein b [Source:ZFIN...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cmtr2	6.193e-8	35.09	cap methyltransferase 2 [Source:Xenbase;Acc:XB-GEN...	[more]
tfpi2	9.180e-8	38.18	tissue factor pathway inhibitor 2 [Source:NCBI gen...	[more]
rlbp1	1.523e-7	41.38	retinaldehyde binding protein 1 [Source:Xenbase;Ac...	[more]
cmtr2	2.087e-7	32.73	cap methyltransferase 2 [Source:Xenbase;Acc:XB-GEN...	[more]
APLP2	2.189e-7	34.55	amyloid beta (A4) precursor-like protein 2 [Source...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Spint3	4.028e-10	39.29	serine peptidase inhibitor, Kunitz type, 3 [Source...	[more]
Wfdc6b	1.422e-9	38.81	WAP four-disulfide core domain 6B [Source:MGI Symb...	[more]
Wfdc6a	6.642e-9	33.33	WAP four-disulfide core domain 6A [Source:MGI Symb...	[more]
Wfdc6a	6.642e-9	33.33	WAP four-disulfide core domain 6A [Source:MGI Symb...	[more]
App	7.363e-9	43.48	amyloid beta (A4) precursor protein [Source:MGI Sy...	[more]

BLAST of Tissue factor pathway inhibitor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P0DN12\|VKT8_ANEVI	4.379e-11	37.50	U-actitoxin-Avd3k OS=Anemonia viridis OX=51769 PE=...	[more]
sp\|P0DN20\|VKTG_ANEVI	4.694e-11	38.57	U-actitoxin-Avd3s (Fragment) OS=Anemonia viridis O...	[more]
sp\|Q8IUA0\|WFDC8_HUMAN	5.706e-11	40.30	WAP four-disulfide core domain protein 8 OS=Homo s...	[more]
sp\|P10646\|TFPI1_HUMAN	1.558e-10	48.15	Tissue factor pathway inhibitor OS=Homo sapiens OX...	[more]
sp\|Q28864\|TFPI1_MACMU	1.653e-10	48.15	Tissue factor pathway inhibitor OS=Macaca mulatta ...	[more]

BLAST of Tissue factor pathway inhibitor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0N4VWW6	1.646e-12	41.89	BPTI/Kunitz inhibitor domain-containing protein OS...	[more]
A0A5K3F6A2	1.064e-11	42.25	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A2K5RB57	2.565e-11	49.12	Serine peptidase inhibitor, Kunitz type 3 OS=Cebus...	[more]
A0A3S2LXI9	2.929e-11	41.43	BPTI/Kunitz inhibitor domain-containing protein OS...	[more]
A0A0F7Z579	3.551e-11	46.58	Tissue factor pathway inhibitor OS=Crotalus adaman...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
appb	4.005e-13	40.98	amyloid beta A4 protein-like [Source:NCBI gene;Acc...	[more]
appb	4.020e-13	40.98	amyloid beta A4 protein-like [Source:NCBI gene;Acc...	[more]
aplp2	2.449e-11	38.71	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	2.454e-11	38.71	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	2.458e-11	38.71	amyloid beta precursor like protein 2 [Source:NCBI...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000008261.1	6.480e-8	37.74	pep scaffold:Pmarinus_7.0:GL478901:735:1448:1 gene...	[more]
tfpi2	1.115e-7	37.74	tissue factor pathway inhibitor 2 [Source:ZFIN;Acc...	[more]
ENSPMAT00000005043.1	1.874e-7	36.84	pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 g...	[more]
WFIKKN1	1.912e-7	33.82	WAP, follistatin/kazal, immunoglobulin, kunitz and...	[more]
ENSPMAT00000009465.1	2.112e-7	43.48	pep scaffold:Pmarinus_7.0:GL478507:22936:25713:-1 ...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Tissue factor pathway inhibitor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO40368	7.819e-10	52.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31760	1.683e-9	45.28	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29819	5.531e-9	42.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO26072	5.271e-8	40.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38466	5.800e-8	40.74	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Tissue factor pathway inhibitor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
aplp2	1.307e-10	42.59	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	1.310e-10	42.59	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
aplp2	1.312e-10	42.59	amyloid beta precursor like protein 2 [Source:NCBI...	[more]
appb	6.302e-10	37.93	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]
APP	1.617e-9	36.21	amyloid-beta A4 protein [Source:NCBI gene;Acc:1011...	[more]

BLAST of Tissue factor pathway inhibitor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000044323.1	6.210e-51	100.00	SMESG000044323.1	[more]
SMESG000037999.1	3.535e-10	38.89	SMESG000037999.1	[more]
SMESG000037999.1	3.960e-10	38.89	SMESG000037999.1	[more]
SMESG000005324.1	4.771e-10	39.71	SMESG000005324.1	[more]
SMESG000037995.1	8.321e-10	38.89	SMESG000037995.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence

transcript sequence

>SMED30028151 ID=SMED30028151|Name=Tissue factor pathway inhibitor|organism=Schmidtea mediterranea sexual|type=transcript|length=404bp
AAAAACGATTCAGTAATTTAGTAAAATAAATTCAAAACAAAAACTAACAA
AATGAAATTGGTGCTCGCAATTTGCTTTGTAATCTGCTTCATTCAAACAT
TGGATTGTTTGAATAAAATCTGTACGAAACCAGTTGAACGTGGAAATTGT
AAAGCGAGTATGGATAGATTTTCTTATAGCACGGAGCATGGCAAATGCAT
ACCATTTAAATTTACCGGCTGCAGAGGAAACGAAAATAATTTCATCAATG
AAGCCGCTTGCAATAAGATTTGTTCTCGAGGAGTATGAATGTTAACAAAT
TATTAATAAATTTTTTGTTTTACTTTTCATGAATTGTTATAAATATTGAA
ATAAATTAAATAATTAAATTCAATAAATATATTTAATAAATTGGCTTGTC
CAGC

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region

Vocabulary: **biological process**
Term	Definition
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity

Vocabulary: **molecular function**
Term	Definition
GO:0030414	peptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000419	prepharyngeal region
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR036880	Kunitz_BPTI_sf
IPR002223	Kunitz_BPTI
IPR020901	Prtase_inh_Kunz-CS

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PRINTS	PR00759	BASICPTASE	coord: 59..74 score: 43.71 coord: 49..59 score: 48.48 coord: 21..35 score: 32.34
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	SMART	SM00131	KU_2	coord: 22..75 e-value: 7.9E-18 score: 75.2
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PFAM	PF00014	Kunitz_BPTI	coord: 23..74 e-value: 2.7E-16 score: 59.5
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PROSITE	PS50279	BPTI_KUNITZ_2	coord: 24..74 score: 13.704
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	CDD	cd00109	KU	coord: 23..74 e-value: 9.54001E-16 score: 62.2674
IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	GENE3D	G3DSA:4.10.410.10		coord: 20..76 e-value: 1.1E-18 score: 68.9
IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	SUPERFAMILY	SSF57362	BPTI-like	coord: 12..75
None	No IPR available	PANTHER	PTHR10083:SF333	SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 3	coord: 22..74
None	No IPR available	PANTHER	PTHR10083	KUNITZ-TYPE PROTEASE INHIBITOR-RELATED	coord: 22..74
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..19 score: 0.807
IPR020901	Proteinase inhibitor I2, Kunitz, conserved site	PROSITE	PS00280	BPTI_KUNITZ_1	coord: 52..70

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Tissue factor pathway inhibitor

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Owlery

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