Phosphoribosylformylglycinamidine synthase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028144 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9Note: Hover over icons to view figure legend
Homology
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Human
Match: PFAS (phosphoribosylformylglycinamidine synthase [Source:HGNC Symbol;Acc:HGNC:8863]) HSP 1 Score: 1187.56 bits (3071), Expect = 0.000e+0 Identity = 645/1271 (50.75%), Postives = 835/1271 (65.70%), Query Frame = 2
Query: 338 NMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPV-FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVAL------EEELDPS-MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTP--TVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPY--NKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRD-------IILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWV 4081
++ +E+GPRLNF TP STN V + ++ G + R E + Y S + + +HD+MTE +PH I SF+ P P+ I+I+ EG ALE+ N+ +GLA+D WDL +Y F + RNPS VE FDLAQSNSEHSRHWFFKGQ+ +DG ++ SLF+ + TQ+ SN NNV+ F DNSSAI+G L DP PS ++ + ++V FTAETHNFPTGV PF GA TGTGGRIRD+Q G G +VVAGTAGYCFGNL +P Y LPWE DP F+YP NFA+ ++ IEASNGASDYGN+FGEPV+ GF RS G+ G+ +EWIKPIMFSGGIG + + H++K +P V+K+GGPVYRIGVGGGAASSV++QGD++ D LD GAVQRGD +ME KMNRVIR C++ NPI S+HDQGAGGNGNVLKEL DP GAII S F LGDPT+N LE+WGAEYQESN LL+ + D + RERCP VG +TGD I L++ + + P+ +P VDL+L VLGKMP+K+F+L+ +L PL LP L V AL RVLRLP+V SKR+LTNKVDRSV GLVAQQQCVGPL TPLADVA+VALS+ +++GAATA+GEQP+K L++ K A+L V EALTNL VT D+K SGNWMW AKLPGEGAAL DAC A +++ L +A+DGGKDSLSMAA V T V++PGSLV+SAY CPDI VTPDLK G G L+++ ++ Q+RLGG+ALAQ + QLG+ P+ D ++++ Q + ++L + HD+SDGGL+ CLLEMAFAGN G+ V + +S+LF EE G ++EV L+ V+ L +GH+ E P V ++VN + +GE R +WE+TS+ L++LQ CV +E + G + + ++ K + RVAILREEGSNGDREMA AF +GFE WD+TMQDL S I L+ F G+ FVGGFS+ DVLGSAKGWAAA+ ++ + + + F+ R DTFSLGVCNGCQL+ LGW+ + D EM D ++L HN S R+ESR++ V + ++ML + GA L VW AHGEG F++ E +Q + GL L++ + D + YP NPNGS VAG+CS DGRHLA+MPHPER+ WQWA+ + SPW+ +F +A W
Sbjct: 85 DLLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVETTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSFSPESMPEPLNGPINILGEGRLALEKANQELGLALDSWDLDFYTKRFQE-LQRNPSTVEAFDLAQSNSEHSRHWFFKGQLHVDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQGLRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGYNLPWE-DPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSD--LDFGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTSRFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVLVDDRECPVRRNGQGDAPPTPLPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLSVHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIGAATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGTET-VRAPGSLVISAYAVCPDITATVTPDLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLKDRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDV--------PVPRVDVLSVLFAEEPGLVLEVQEPDLAQVLKRYRDAGLHCLELGHTG---EAGPHAMVRVSVNGAVVLEE-PVGELRALWEETSFQLDRLQAEPRCVAEEER--GLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAGAELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSGRYESRWASVRV-GPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWADDDGNPTE--QYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTSPWLQLFINARNWT 1333
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Human
Match: PFAS (phosphoribosylformylglycinamidine synthase [Source:HGNC Symbol;Acc:HGNC:8863]) HSP 1 Score: 261.536 bits (667), Expect = 7.697e-77 Identity = 148/357 (41.46%), Postives = 206/357 (57.70%), Query Frame = 2
Query: 2756 IFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTP--TVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPY--NKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRD-------IILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFE 3793
+ ++L + HD+SDGGL+ CLLEMAFAGN G+ V + +S+LF EE G ++EV L+ V+ L +GH+ E P V ++VN + +GE R +WE+TS+ L++LQ CV +E + G + + ++ K + RVAILREEGSNGDREMA AF +GFE WD+TMQDL S I L+ F G+ FVGGFS+ DVLGSAKGWAAA+ ++ + + + F+ R DTFSLGVCNGCQL+ LGW+ + D EM D ++L HN S R+ESR++ V + ++ML + GA L VW AHGEG+ +
Sbjct: 2 LLKDRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDV--------PVPRVDVLSVLFAEEPGLVLEVQEPDLAQVLKRYRDAGLHCLELGHTG---EAGPHAMVRVSVNGAVVLEE-PVGELRALWEETSFQLDRLQAEPRCVAEEER--GLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAGAELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSGRYESRWASVRV-GPGPALMLRGMEGAVLPVWSAHGEGQAQ 343
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Human
Match: PFAS (phosphoribosylformylglycinamidine synthase [Source:HGNC Symbol;Acc:HGNC:8863]) HSP 1 Score: 108.612 bits (270), Expect = 4.485e-27 Identity = 55/82 (67.07%), Postives = 64/82 (78.05%), Query Frame = 2
Query: 1481 AASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTL 1726
AASSV++QGD++ D LD GAVQRGD +ME KMNRVIR C++ NPI S+HDQGAGGNGNVLKEL DP GAII S F +
Sbjct: 20 AASSVQVQGDNTSD--LDFGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTSRFQI 99
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Human
Match: PFAS (phosphoribosylformylglycinamidine synthase [Source:HGNC Symbol;Acc:HGNC:8863]) HSP 1 Score: 52.373 bits (124), Expect = 6.264e-8 Identity = 22/53 (41.51%), Postives = 35/53 (66.04%), Query Frame = 2
Query: 2732 KSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCD 2890
++++ Q + ++L + HD+SDGGL+ CLLEMAFAGN G+ V + D +
Sbjct: 5 RAFSITQGLLKDRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDVPVPRVDAE 57
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Celegans
Match: pfas-1 (Probable phosphoribosylformylglycinamidine synthase [Source:UniProtKB/Swiss-Prot;Acc:Q19311]) HSP 1 Score: 1016.14 bits (2626), Expect = 0.000e+0 Identity = 602/1292 (46.59%), Postives = 807/1292 (62.46%), Query Frame = 2
Query: 332 KYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPI-LYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKG--DGSLIWIRMNS---QYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIF-MEKLAS--------AAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVN-ELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNK---------------EYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVN----LDATNDDV-VNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDL-------DVSTEVSPWMCIFNSAYEW 4078
++ +IEIGPR T TN + I +S G + R E Y + D N+ + DKMTE Y + + + + VF ID++ E + L + N+ +GLA+D+ DL +Y+D FVN + +NP++VE FDLAQS+SEHSRHWFF+G++ ID + + SL + ET SN N++IAF DNSSAI+GF + L NDP S ++ ++AETHNFPT V PF GA TGTGGRIRDI A G G Y +AGT GY FGNL LP LPWE D F+YP++ ++ +KI IEASNGASDYGN+FGEPVI+GF RSFG +GE E++KPIMFSGGIG + V K +Q V+KIGGPVYRIGVGGGAASSV +QG+ R+ +LD AVQRGDA+M K++RV+R C + NP+ +IHDQGAGGNGNV+KELV+ G + + F LGD +I+L ELW AEYQE++ L+D LD + I RE+C ++VVG+V + ++L L S VDLD + LG+ KK F LK ++L L+LP NL V AL RVL LPSV SKR+LT KVDRSV+GLVAQQQCVGPLHTPLADVA+VALS+FD VG A ++GEQPIKMLI+ ++GA++C+ E + NL P+T +D+K+SGNWMW AK GEGA L DA A C L+++ AIDGGKDSLSMA T + VVKSPG+LV+SAY C ++ V P LK ++WI++ S + RLGGSALAQVY Q+GD CP+ +N K ++ +Q++ E+LA A HDISDGGL+ +LEMAFAGNV ID+ I + + I ILF EE G ++EV N V++ + IG + + V + VN L I N KL + R WE L + Q N + + + ++ +Y NP N + S RVAI+REEGSNGDREMA+AF +GF+T+D+TM D+L+ TLE + G+ FVGGFS+ DVLGSAKGWAA +++NE + K+F+ F+ R DTFS GVCNGCQLM LGW+ D + + L N+ RF+S F V I +N SIMLS + + LG+W +HGEG+F + N + ++G + + + + A + V + YP+NPNGSI +VA +CS+DGRHLA+MPH +RSF+ WQWA + ++ + +SPW+ +F +AY W
Sbjct: 80 EHGKNIEIGPRTAVKTAACTNILSIFESSGIKNVERIERGIRYLVEDDVD-----VNEFFEIAADKMTEAIYGNDVKFDDESHQIEKVFLIDVL-ESKQNLIKANEELGLALDQLDLDFYYDFFVNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIWIDDRKRDGSLMKTIRETLDSSNDNSLIAFCDNSSAIRGFESVCRLRPNDPTTVSPMIAIFPPSHLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGRGAYEIAGTVGYSFGNLNLPGLPLPWE-DETFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARSFGQRLENGERCEYLKPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVSVQGN--RENQLDFAAVQRGDAEMGGKLHRVVRACAERIGGNPLMAIHDQGAGGNGNVIKELVEGCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKL---------LGKSGEIAVDLD-TRQLGEREKKVFKLKSAPRVLKKLELPENLTVRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSLGEQPIKMLIDAEKGARMCIAETIMNLIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGALCRGLREIGCAIDGGKDSLSMAVTAH-GEVVKSPGTLVLSAYAPCTNVTKVVNPSLKAVPGSKILWIKIGSSEEKMRLGGSALAQVYSQIGDDCPDIENFSEISKVFSIVQQLLNREELAGPLRKPIILAGHDISDGGLLTAILEMAFAGNVSIDIDIKP------PNQNIKPIDILFAEECGILLEVSNP--ENVLHIFSEAGIKCQEIGKASAVFGPDAHVKIHVNGHLEI--NEKLVDLREEWELVGDRLGEFQTNPKSLKEAREVRRTCQKINYKCDFDWYYNPAFIHN------------EQYFSTAPRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-TLEAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQFEAFRSRPDTFSYGVCNGCQLMAQLGWIGDEE-----QKGPTVFLDENECGRFDSSFGPVKIEKNV-SIMLSGMENSVLGLWSSHGEGRFTYRNLQNFQNLKTNGQVCIRFCDDRGMTGADHGSVKLPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQWAESSEVPWNARFDQKTVALSPWIKMFRNAYNW 1322
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Fly
Match: Pfas (gene:FBgn0000052 transcript:FBtr0079221) HSP 1 Score: 1115.52 bits (2884), Expect = 0.000e+0 Identity = 634/1367 (46.38%), Postives = 844/1367 (61.74%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDN-NLLDGTIIATS-EICYNIEIKGXXXXXXXXXXXXXXITRS--DNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQIN---SFNLNVAPSPV--FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPC-FKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGM--ITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDP--LGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVA---LEEELDPSMPYIV---DLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDG-----SLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSA------EISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEY---QFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG---DLDVSTEVSPWMCIFNSAYEWVEK 4087
M +L +Y + + S + +++ DG +++ E CY++E L LL + + +S +P + +EIGPR NF TP STN V I ++LG++ + R E S Y + + + + + D+MT+ Y + SF+ + + ++ EG ALE IN+ +GLA +++DL YYHD+F + RNP+ VE FD AQSNSEHSRHWFF+G+M+IDGVE +SL ++ +TQ ++N NN I FSDNSSA+ GF + + P ++ ++ FTAETHN PT VAPF GA TGTGGR+RD+Q VG GG +AGTAGYC G L +P Y P+E P FKYP+ FA +++IEASNGASDYGN+FGEPVI+GF S+G+ + + E++KPIMFSGG+G + + K P QL+ KIGGPVYRIGVGGGAASSVEIQG S D ELD AVQRGDA+MENK+NRV+R C+DL + NPI +IHDQGAGGNGNVLKELV+P GA+I + F LGDPTI LELWGAEYQE+N +L + + +KIC RERCPI+ VG VTGDG + L+ A LE+ L+ S V DL+L VLG MPK+ + LK + L L LP L +++AL RVL L +VGSKRFLTNKVDR V GL+AQQQCVGPL PLAD A+ +S+F G AT+IG QP+K L++ A++CV EAL+NL + ++ D+K SGNWMW AKLPGEGA ++DAC C +L++L IAIDGGKDSLSMAA V T +KSPG+LV+S Y CPD+RL VTPDLKG G SL+WI + + RLGGSALAQ Y Q G P + K++ Q + + L A HD+SDGGL+ C+LEMA G G+ V ++ +A + S E+++LF EE GW++EV + L V + E + +G + + + + V L + + L WE TSY LEKLQ N EC EY ++ P V ++ L K +S RVA+LREEG N +REM A +++ FE D+TM DLL ++ ++ GLIF GGFS+ D LGSAKGWAA I +N ++ +F+ FK R+D FSLG+CNGCQLMT +G++ + S D+ L HN S RFE R++ V IP N +SIML + LG WVAHGEG+F F +++ S S+ L+ L YV D YP NPNGS +AGLCS DGRHLA+MPHPER +QW Y ++ + SPW +FN+AY W K
Sbjct: 1 MVILRYYDVQAHSAAEEESVLRRLREEDGAVVSVRMERCYHLEYSAQAEHSLALDELLVWLVKQPLSKGQSLSRQPALQSTGSSQLLLEIGPRFNFSTPYSTNCVNIFQNLGYSEVRRMETSTRYLVTFGEGSKAPEAARFVPLLGDRMTQCLYTEENTPKASFDEQLPERQANWHFVPVLEEGRAALERINQELGLAFNDYDLDYYHDLFAKELGRNPTTVELFDCAQSNSEHSRHWFFRGRMVIDGVEQPKSLIRMIMDTQAHTNPNNTIKFSDNSSAMVGFDHQTIVPSSVVAPGAVRLQSVQSDLIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGVPIAGTAGYCVGALHIPGYKQPYE--PLDFKYPATFAPPLQVLIEASNGASDYGNKFGEPVISGFALSYGLNSAADASQRDEYVKPIMFSGGLGTMPATMREKLPPARGQLLAKIGGPVYRIGVGGGAASSVEIQG--SGDAELDFNAVQRGDAEMENKLNRVVRACLDLGEQNPILAIHDQGAGGNGNVLKELVEPGFAGAVIFSKEFQLGDPTITALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTGDGRVTLLEKPAPKDLEQALNASNRSEVSPFDLELKYVLGDMPKRTYDLKREQTPLKELSLPKGLLLDEALERVLSLVAVGSKRFLTNKVDRCVGGLIAQQQCVGPLQAPLADYALTTVSHFSHSGIATSIGTQPLKGLLDPAAMARMCVAEALSNLVFVKISELADVKCSGNWMWAAKLPGEGARMFDACKELCQILEELHIAIDGGKDSLSMAAKVGGET-IKSPGTLVISTYAPCPDVRLKVTPDLKGPGAGSKTSLLWINLENSARLGGSALAQAYAQQGKDTPNLTRSDVLGKAFAVTQSLLGDGLIQAGHDVSDGGLLVCVLEMAIGGLSGLRVDLSEPLAKLKNFDKSVEKLNRPELAVLFAEECGWVVEVLDTDLERVRSTYEKAGVPNYYLGVT-EGFGLDSRVVLKNGKSELLDQ-PLRVLYKKWERTSYELEKLQANPECAEAEYNSLEYRQAPQYRGPQNVQAELTL----KRSSAPVRVAVLREEGVNSEREMMACLLRANFEVHDVTMSDLLQGTASVSQYRGLIFPGGFSYADTLGSAKGWAANILHNPRLLPQFEAFKRRQDVFSLGICNGCQLMTLIGFVGSAKS--EVGADPDVALLHNKSQRFECRWATVKIPSN-RSIMLGSMKDLVLGCWVAHGEGRFAFRDEKLISHLQSEQLVTLQYV--DDVGKPTELYPLNPNGSPQGIAGLCSSDGRHLALMPHPERCSSMYQWPYVPSSFEVSPTQSESPWQIMFNNAYNWCVK 1351
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Fly
Match: Pfas (gene:FBgn0000052 transcript:FBtr0079220) HSP 1 Score: 1115.52 bits (2884), Expect = 0.000e+0 Identity = 634/1367 (46.38%), Postives = 844/1367 (61.74%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDN-NLLDGTIIATS-EICYNIEIKGXXXXXXXXXXXXXXITRS--DNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQIN---SFNLNVAPSPV--FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPC-FKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGM--ITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDP--LGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVA---LEEELDPSMPYIV---DLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDG-----SLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSA------EISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEY---QFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG---DLDVSTEVSPWMCIFNSAYEWVEK 4087
M +L +Y + + S + +++ DG +++ E CY++E L LL + + +S +P + +EIGPR NF TP STN V I ++LG++ + R E S Y + + + + + D+MT+ Y + SF+ + + ++ EG ALE IN+ +GLA +++DL YYHD+F + RNP+ VE FD AQSNSEHSRHWFF+G+M+IDGVE +SL ++ +TQ ++N NN I FSDNSSA+ GF + + P ++ ++ FTAETHN PT VAPF GA TGTGGR+RD+Q VG GG +AGTAGYC G L +P Y P+E P FKYP+ FA +++IEASNGASDYGN+FGEPVI+GF S+G+ + + E++KPIMFSGG+G + + K P QL+ KIGGPVYRIGVGGGAASSVEIQG S D ELD AVQRGDA+MENK+NRV+R C+DL + NPI +IHDQGAGGNGNVLKELV+P GA+I + F LGDPTI LELWGAEYQE+N +L + + +KIC RERCPI+ VG VTGDG + L+ A LE+ L+ S V DL+L VLG MPK+ + LK + L L LP L +++AL RVL L +VGSKRFLTNKVDR V GL+AQQQCVGPL PLAD A+ +S+F G AT+IG QP+K L++ A++CV EAL+NL + ++ D+K SGNWMW AKLPGEGA ++DAC C +L++L IAIDGGKDSLSMAA V T +KSPG+LV+S Y CPD+RL VTPDLKG G SL+WI + + RLGGSALAQ Y Q G P + K++ Q + + L A HD+SDGGL+ C+LEMA G G+ V ++ +A + S E+++LF EE GW++EV + L V + E + +G + + + + V L + + L WE TSY LEKLQ N EC EY ++ P V ++ L K +S RVA+LREEG N +REM A +++ FE D+TM DLL ++ ++ GLIF GGFS+ D LGSAKGWAA I +N ++ +F+ FK R+D FSLG+CNGCQLMT +G++ + S D+ L HN S RFE R++ V IP N +SIML + LG WVAHGEG+F F +++ S S+ L+ L YV D YP NPNGS +AGLCS DGRHLA+MPHPER +QW Y ++ + SPW +FN+AY W K
Sbjct: 1 MVILRYYDVQAHSAAEEESVLRRLREEDGAVVSVRMERCYHLEYSAQAEHSLALDELLVWLVKQPLSKGQSLSRQPALQSTGSSQLLLEIGPRFNFSTPYSTNCVNIFQNLGYSEVRRMETSTRYLVTFGEGSKAPEAARFVPLLGDRMTQCLYTEENTPKASFDEQLPERQANWHFVPVLEEGRAALERINQELGLAFNDYDLDYYHDLFAKELGRNPTTVELFDCAQSNSEHSRHWFFRGRMVIDGVEQPKSLIRMIMDTQAHTNPNNTIKFSDNSSAMVGFDHQTIVPSSVVAPGAVRLQSVQSDLIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGVPIAGTAGYCVGALHIPGYKQPYE--PLDFKYPATFAPPLQVLIEASNGASDYGNKFGEPVISGFALSYGLNSAADASQRDEYVKPIMFSGGLGTMPATMREKLPPARGQLLAKIGGPVYRIGVGGGAASSVEIQG--SGDAELDFNAVQRGDAEMENKLNRVVRACLDLGEQNPILAIHDQGAGGNGNVLKELVEPGFAGAVIFSKEFQLGDPTITALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTGDGRVTLLEKPAPKDLEQALNASNRSEVSPFDLELKYVLGDMPKRTYDLKREQTPLKELSLPKGLLLDEALERVLSLVAVGSKRFLTNKVDRCVGGLIAQQQCVGPLQAPLADYALTTVSHFSHSGIATSIGTQPLKGLLDPAAMARMCVAEALSNLVFVKISELADVKCSGNWMWAAKLPGEGARMFDACKELCQILEELHIAIDGGKDSLSMAAKVGGET-IKSPGTLVISTYAPCPDVRLKVTPDLKGPGAGSKTSLLWINLENSARLGGSALAQAYAQQGKDTPNLTRSDVLGKAFAVTQSLLGDGLIQAGHDVSDGGLLVCVLEMAIGGLSGLRVDLSEPLAKLKNFDKSVEKLNRPELAVLFAEECGWVVEVLDTDLERVRSTYEKAGVPNYYLGVT-EGFGLDSRVVLKNGKSELLDQ-PLRVLYKKWERTSYELEKLQANPECAEAEYNSLEYRQAPQYRGPQNVQAELTL----KRSSAPVRVAVLREEGVNSEREMMACLLRANFEVHDVTMSDLLQGTASVSQYRGLIFPGGFSYADTLGSAKGWAANILHNPRLLPQFEAFKRRQDVFSLGICNGCQLMTLIGFVGSAKS--EVGADPDVALLHNKSQRFECRWATVKIPSN-RSIMLGSMKDLVLGCWVAHGEGRFAFRDEKLISHLQSEQLVTLQYV--DDVGKPTELYPLNPNGSPQGIAGLCSSDGRHLALMPHPERCSSMYQWPYVPSSFEVSPTQSESPWQIMFNNAYNWCVK 1351
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Fly
Match: Pfas (gene:FBgn0000052 transcript:FBtr0079219) HSP 1 Score: 1115.52 bits (2884), Expect = 0.000e+0 Identity = 634/1367 (46.38%), Postives = 844/1367 (61.74%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDN-NLLDGTIIATS-EICYNIEIKGXXXXXXXXXXXXXXITRS--DNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQIN---SFNLNVAPSPV--FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPC-FKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGM--ITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDP--LGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVA---LEEELDPSMPYIV---DLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDG-----SLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSA------EISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEY---QFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG---DLDVSTEVSPWMCIFNSAYEWVEK 4087
M +L +Y + + S + +++ DG +++ E CY++E L LL + + +S +P + +EIGPR NF TP STN V I ++LG++ + R E S Y + + + + + D+MT+ Y + SF+ + + ++ EG ALE IN+ +GLA +++DL YYHD+F + RNP+ VE FD AQSNSEHSRHWFF+G+M+IDGVE +SL ++ +TQ ++N NN I FSDNSSA+ GF + + P ++ ++ FTAETHN PT VAPF GA TGTGGR+RD+Q VG GG +AGTAGYC G L +P Y P+E P FKYP+ FA +++IEASNGASDYGN+FGEPVI+GF S+G+ + + E++KPIMFSGG+G + + K P QL+ KIGGPVYRIGVGGGAASSVEIQG S D ELD AVQRGDA+MENK+NRV+R C+DL + NPI +IHDQGAGGNGNVLKELV+P GA+I + F LGDPTI LELWGAEYQE+N +L + + +KIC RERCPI+ VG VTGDG + L+ A LE+ L+ S V DL+L VLG MPK+ + LK + L L LP L +++AL RVL L +VGSKRFLTNKVDR V GL+AQQQCVGPL PLAD A+ +S+F G AT+IG QP+K L++ A++CV EAL+NL + ++ D+K SGNWMW AKLPGEGA ++DAC C +L++L IAIDGGKDSLSMAA V T +KSPG+LV+S Y CPD+RL VTPDLKG G SL+WI + + RLGGSALAQ Y Q G P + K++ Q + + L A HD+SDGGL+ C+LEMA G G+ V ++ +A + S E+++LF EE GW++EV + L V + E + +G + + + + V L + + L WE TSY LEKLQ N EC EY ++ P V ++ L K +S RVA+LREEG N +REM A +++ FE D+TM DLL ++ ++ GLIF GGFS+ D LGSAKGWAA I +N ++ +F+ FK R+D FSLG+CNGCQLMT +G++ + S D+ L HN S RFE R++ V IP N +SIML + LG WVAHGEG+F F +++ S S+ L+ L YV D YP NPNGS +AGLCS DGRHLA+MPHPER +QW Y ++ + SPW +FN+AY W K
Sbjct: 1 MVILRYYDVQAHSAAEEESVLRRLREEDGAVVSVRMERCYHLEYSAQAEHSLALDELLVWLVKQPLSKGQSLSRQPALQSTGSSQLLLEIGPRFNFSTPYSTNCVNIFQNLGYSEVRRMETSTRYLVTFGEGSKAPEAARFVPLLGDRMTQCLYTEENTPKASFDEQLPERQANWHFVPVLEEGRAALERINQELGLAFNDYDLDYYHDLFAKELGRNPTTVELFDCAQSNSEHSRHWFFRGRMVIDGVEQPKSLIRMIMDTQAHTNPNNTIKFSDNSSAMVGFDHQTIVPSSVVAPGAVRLQSVQSDLIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGVPIAGTAGYCVGALHIPGYKQPYE--PLDFKYPATFAPPLQVLIEASNGASDYGNKFGEPVISGFALSYGLNSAADASQRDEYVKPIMFSGGLGTMPATMREKLPPARGQLLAKIGGPVYRIGVGGGAASSVEIQG--SGDAELDFNAVQRGDAEMENKLNRVVRACLDLGEQNPILAIHDQGAGGNGNVLKELVEPGFAGAVIFSKEFQLGDPTITALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTGDGRVTLLEKPAPKDLEQALNASNRSEVSPFDLELKYVLGDMPKRTYDLKREQTPLKELSLPKGLLLDEALERVLSLVAVGSKRFLTNKVDRCVGGLIAQQQCVGPLQAPLADYALTTVSHFSHSGIATSIGTQPLKGLLDPAAMARMCVAEALSNLVFVKISELADVKCSGNWMWAAKLPGEGARMFDACKELCQILEELHIAIDGGKDSLSMAAKVGGET-IKSPGTLVISTYAPCPDVRLKVTPDLKGPGAGSKTSLLWINLENSARLGGSALAQAYAQQGKDTPNLTRSDVLGKAFAVTQSLLGDGLIQAGHDVSDGGLLVCVLEMAIGGLSGLRVDLSEPLAKLKNFDKSVEKLNRPELAVLFAEECGWVVEVLDTDLERVRSTYEKAGVPNYYLGVT-EGFGLDSRVVLKNGKSELLDQ-PLRVLYKKWERTSYELEKLQANPECAEAEYNSLEYRQAPQYRGPQNVQAELTL----KRSSAPVRVAVLREEGVNSEREMMACLLRANFEVHDVTMSDLLQGTASVSQYRGLIFPGGFSYADTLGSAKGWAANILHNPRLLPQFEAFKRRQDVFSLGICNGCQLMTLIGFVGSAKS--EVGADPDVALLHNKSQRFECRWATVKIPSN-RSIMLGSMKDLVLGCWVAHGEGRFAFRDEKLISHLQSEQLVTLQYV--DDVGKPTELYPLNPNGSPQGIAGLCSSDGRHLALMPHPERCSSMYQWPYVPSSFEVSPTQSESPWQIMFNNAYNWCVK 1351
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Zebrafish
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:ZFIN;Acc:ZDB-GENE-030131-4420]) HSP 1 Score: 1236.86 bits (3199), Expect = 0.000e+0 Identity = 672/1346 (49.93%), Postives = 883/1346 (65.60%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQL--------KKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRN----DIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDL---KGDGSLIWIRMNS-QYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVE 4084
M V+ FY+ R + L +I T+E+CYN+E+ G + + + D + + S P + L + +EIGPRLNF T STNAV I +S G + ++R E+S + + + ++ +I ++D MTE Y I SF +++ P VF +DI+ +G ALE+ N +GLA D WDL YY +F + RNP++VECFDLAQSNSEHSRHWFF+G+M+IDG E +++LF ++ TQ++SNQNNVI F DNSS IKG +Y +PA S YE +D+ ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P + LPWE + ++YPS+FA ++ IEAS+GASDYGN+FGEPV+ GF RSFGM +GE +EWIKPIMFSGG+G + HV K V+KIGGPVYRIGVGGGAASSV++QGD+S + DLGAVQRGDA+ME KMNR +R C++ + NPI SIHDQGAGGNGNVLKEL +P GA+I F GDPT+++LELWGAEYQESN LL+ +++C RE+CP++ VGK+TGDG I L++ + + ++ VDL+L VLGKMP+K+F L+H L PL LP L V AL RVLRLP+V SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+VALS F + GAATAIGEQPIK L++ GA++ V EALTNL V++ +D+K SGNWMW AKLPGEGA LWDAC A C ++ L +A+DGGKDSLSMAA V+ T VK+PGSLV+S Y CPDI VTPDL +G G L+++ +++ +YRLGGSALAQ + QLGD P+ D +N Q + ++L +A HD+SDGGLI CLLEMAFAGN GI+V + D + LF+EE ++EV S+V LL IG + + V +++ + N +L R +WE TS+ LE+LQ N CV +E Q + S ++ + RVA++REEGSNGDREM+A+ +GFE WD+TMQDL S TL+ F ++FVGGFS+ DVLGSAKGWAA + +N + +++F+ F+ REDT SLGVCNGCQL+ LGW+ + + D+ L+HN S RFESRF V I + +IML + G+ LGVWVAHGEG +F + E + + L L YV+ D+ N + YP NPNGS VAG+CS DGRHLA+MPHPER+ + WQWA+ L S E SPW+ +F +A W +
Sbjct: 1 MPVVRFYRTEETGEA--RAIRRIAQLYPDVIITTELCYNVELDGPDSLS---------VAQKDILRWLFSPPYSVSLLEEPTLKAEHGARLVEIGPRLNFSTAWSTNAVSICQSAGLSQVTRVELSRRHLIKPQEGCKVGMKDGEMESLISCLYDSMTECIYAQPITSFAVDIRPQDVFEVDILGKGRAALEKANDELGLAFDSWDLDYYTALFQKV-KRNPTSVECFDLAQSNSEHSRHWFFRGRMVIDGKEQKETLFSLIMGTQQHSNQNNVIKFCDNSSGIKGMELRCMYPTNPAQASPYESRDTTRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGKGGHVIAGTAGYCFGNLHIPGFVLPWEEE-GWEYPSSFAPPLQVAIEASDGASDYGNKFGEPVLAGFARSFGMRLANGERREWIKPIMFSGGLGSIEDPHVRKDQAEPGMEVVKIGGPVYRIGVGGGAASSVQVQGDNSSAR--DLGAVQRGDAEMEQKMNRALRACLERVEGNPICSIHDQGAGGNGNVLKELSEPAGAVIYTEKFKRGDPTLSVLELWGAEYQESNALLLRPSDRSFLERVCQREKCPVDFVGKITGDGKIVLVDGLRKQNDVLEGARNPVDLELDWVLGKMPQKEFILEHRSVSLQPLTLPAGLSVLPALERVLRLPAVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSPFSLQGAATAIGEQPIKGLLSPAAGARMAVGEALTNLVFARVSALKDVKCSGNWMWAAKLPGEGACLWDACQAMCEVMGQLGVAVDGGKDSLSMAARVSGET-VKAPGSLVISVYAVCPDITATVTPDLDNPEGKGVLLYVPVSAGKYRLGGSALAQCFGQLGDCSPDMDQPDKLSACFNTTQTLIQDRLLTAGHDVSDGGLISCLLEMAFAGNYGIEVDLPLEGVDV--------MEALFSEELSLVLEVCERNASSVCQRYTDAGLLCHRIG-TTSGFGPDAKVRVSLCGREVL-NERLPTLRAIWESTSFELERLQANPLCVQEEEQGLASRTQPYLKLTFDPSQTPIIKELATGKARVAVVREEGSNGDREMSASLFMAGFEVWDVTMQDLCSGSTTLDPFRAVVFVGGFSYADVLGSAKGWAATVTFNNRAREEFERFRKREDTLSLGVCNGCQLLALLGWVGERE-----DGGSDVTLTHNKSGRFESRFVSVGI-LPSPAIMLKGMEGSALGVWVAHGEGLMQFRSPEAQQKLIGSSLAPLRYVD-DSGNPTEI-YPINPNGSAQGVAGICSADGRHLAMMPHPERAVLSWQWAWAPQHLRGSLEPSPWLSMFRNAAAWCQ 1312
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Xenopus
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:100216263]) HSP 1 Score: 1260.74 bits (3261), Expect = 0.000e+0 Identity = 691/1350 (51.19%), Postives = 893/1350 (66.15%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITR----SDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPS----MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGS---LIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNP--NITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCE--MKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVEK 4087
M VLHFY+ + S++ R N+ E+CYN+ G Q L + +I+D SS + ++ +EIGPRLNF T STNAV I +S+G + R E S Y + S+ +++ +++D+MTE YP + SF ++V P V+ +DI+ +G ALE+ N +GLA D WDL YY +F + RNPS+VECFDLAQSNSEHSRHWFFKG++ +DG E E SLFD++ +TQ SN NNVI F DNSSAI+G L DP+ Y + S +++ FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G G +V+AGTAGYCFGNL +P Y+LPWE D ++YP FA+ ++ IEASNGASDYGN+FGEPV+ GF RSFG+ SGE +EW+KPIMFSGGIG + +H K +P V+K+GGPVYRIGVGGGAASS+++QGD++ ELD GAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I +F LGDPT+++LE+WGAEYQESN LL+ + + +C RER P++ VGK+TGDG I LIN + D + +P VDL L VLGKMP+K+F L V L PL LP L V AL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+V+LSY DIVG ATAIGEQPIK L+N GA+L V EALTNL VT +D+K SGNWMW AKLPGEGA L+DAC A C ++ L +AIDGGKDSLSMAA V T VK+PGSLV+S Y CPDI VTPDLK G L+++ + Q+RLGGSALAQ Y QLG+ P+ D+ +N Q++ +++ SA HD+SDGGL+ C+LEMAFAGN G+D+ I++S + + +LF EE G ++EV + V+ + + IG + +R + V + N + N KLG R +WE+TS+ LE+LQ N CV++E + P ++T NP I L P + + RVA++REEGSNGDREMAA+ + +GF+ WD+TM+DLL+ TL+ F GL+FVGGFS+ DVLGSAKGWAA++K+N ++++F+NF+ R DTFSLGVCNGCQLM LGW+ + D + ++LSHN S RFESRF + I Q + SI+L + G+ LGVWVAHGEG F + + S+ L L YV D YP NPNGS +AGLCS DGRHLA+MPHPER M WQW + + S +VSPWM +F + Y W ++
Sbjct: 1 MVVLHFYRSLQNSSETLRLPGAENIQS----LQRELCYNVNWTGPAAPSSQETDALRWLFSCPFDPQSISDTSS----LHSEPSDLLVEIGPRLNFSTATSTNAVSICRSVGLTNVDRIECSKRYLIKFQTRPQGSEEQELLASLYDRMTECVYPEPVRSFEVSVRPEKVYEVDILGQGRAALEKANTELGLAFDSWDLDYYSSLFQRV-GRNPSSVECFDLAQSNSEHSRHWFFKGKLKVDGQEKEMSLFDMIMKTQDTSNPNNVIKFCDNSSAIQGREVASLIPTDPSCAGPYHLCRSTRHLIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSTGRGAHVIAGTAGYCFGNLHIPGYSLPWE-DLAYQYPVQFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGLRLPSGERREWVKPIMFSGGIGSMEDVHRTKEAPEPGMHVVKVGGPVYRIGVGGGAASSIQVQGDNA--SELDFGAVQRGDAEMEQKMNRAVRACVERGGKNPICSIHDQGAGGNGNVLKELSEPQGAVIYTKSFQLGDPTLSVLEIWGAEYQESNALLLRPDDAEFLRSVCRRERSPVDFVGKITGDGRIVLINGSDTDPAPDSTDRNAVP--VDLQLEWVLGKMPRKEFVLNRVAPNLQPLVLPSGLTVGQALDRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVSLSYSDIVGGATAIGEQPIKSLLNPAAGARLAVAEALTNLLFAQVTDLKDVKCSGNWMWAAKLPGEGALLYDACAAMCDVMAQLGVAIDGGKDSLSMAARVGTET-VKAPGSLVISVYAVCPDITTTVTPDLKNPGQKGVLLYLPLCPGQHRLGGSALAQCYSQLGETPPDLDDPQTLISCFNVTQQLLRDRVLSAGHDVSDGGLVTCILEMAFAGNCGLDIEISSSCTNV--------LELLFAEEPGLVLEVAEQSVELVMERYRAAGVECVRIGCTKERGPAS-MVRIRANGQEVV-NEKLGSLRAVWEETSFQLERLQANPSCVSQEEAGLRVREGPSYHLTFNPSEIP---LVPPS-VGGNQPRVAVVREEGSNGDREMAASLLMAGFQVWDVTMEDLLAGGTTLDSFRGLVFVGGFSYADVLGSAKGWAASVKFNASVREQFENFRRRADTFSLGVCNGCQLMALLGWVGPDNPTDTVGDLPTQGVLLSHNLSGRFESRFVTLKI-QQSPSILLRGMAGSTLGVWVAHGEGYMRFRSPKVQDYVTSNHLAPLCYV--DDGGKPTEEYPMNPNGSPLGIAGLCSADGRHLAMMPHPERCVMKWQWPWMPESWRHSLDVSPWMRLFQNGYRWCQE 1318
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Xenopus
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:100216263]) HSP 1 Score: 1251.5 bits (3237), Expect = 0.000e+0 Identity = 675/1282 (52.65%), Postives = 870/1282 (67.86%), Query Frame = 2
Query: 287 NINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPS----MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGS---LIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNP--NITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMK-RDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVEK 4087
+I+D SS + ++ +EIGPRLNF T STNAV I +S+G + R E S Y N + +++ +++D+MTE YP + SF ++V P V+ +DI+ +G ALE+ N +GLA D WDL YY +F + RNPS+VECFDLAQSNSEHSRHWFFKG++ +DG E E SLFD++ +TQ SN NNVI F DNSSAI+G L DP+ Y + S +++ FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G G +V+AGTAGYCFGNL +P Y+LPWE D ++YP FA+ ++ IEASNGASDYGN+FGEPV+ GF RSFG+ SGE +EW+KPIMFSGGIG + +H K +P V+K+GGPVYRIGVGGGAASS+++QGD++ ELD GAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I +F LGDPT+++LE+WGAEYQESN LL+ + + +C RER P++ VGK+TGDG I LIN + D + +P VDL L VLGKMP+K+F L V L PL LP L V AL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+V+LSY DIVG ATAIGEQPIK L+N GA+L V EALTNL VT +D+K SGNWMW AKLPGEGA L+DAC A C ++ L +AIDGGKDSLSMAA V T VK+PGSLV+S Y CPDI VTPDLK G L+++ + Q+RLGGSALAQ Y QLG+ P+ D+ +N Q++ +++ SA HD+SDGGL+ C+LEMAFAGN G+D+ I++S + + +LF EE G ++EV + V+ + + IG + +R + V + N + N KLG R +WE+TS+ LE+LQ N CV++E + P ++T NP I L P + + RVA++REEGSNGDREMAA+ + +GF+ WD+TM+DLL+ TL+ F GL+FVGGFS+ DVLGSAKGWAA++K+N ++++F+NF+ R DTFSLGVCNGCQLM LGW+ + D ++ + ++LSHN S RFESRF + I Q + SI+L + G+ LGVWVAHGEG F + + S+ L L YV D YP NPNGS +AGLCS DGRHLA+MPHPER M WQW + + S +VSPWM +F + Y W ++
Sbjct: 38 SISDTSS----LHSEPSDLLVEIGPRLNFSTATSTNAVSICRSVGLTNVDRIECSKRYLIKVGNPS-----QELLASLYDRMTECVYPEPVRSFEVSVRPEKVYEVDILGQGRAALEKANTELGLAFDSWDLDYYSSLFQRV-GRNPSSVECFDLAQSNSEHSRHWFFKGKLKVDGQEKEMSLFDMIMKTQDTSNPNNVIKFCDNSSAIQGREVASLIPTDPSCAGPYHLCRSTRHLIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSTGRGAHVIAGTAGYCFGNLHIPGYSLPWE-DLAYQYPVQFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGLRLPSGERREWVKPIMFSGGIGSMEDVHRTKEAPEPGMHVVKVGGPVYRIGVGGGAASSIQVQGDNA--SELDFGAVQRGDAEMEQKMNRAVRACVERGGKNPICSIHDQGAGGNGNVLKELSEPQGAVIYTKSFQLGDPTLSVLEIWGAEYQESNALLLRPDDAEFLRSVCRRERSPVDFVGKITGDGRIVLINGSDTDPAPDSTDRNAVP--VDLQLEWVLGKMPRKEFVLNRVAPNLQPLVLPSGLTVGQALDRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVSLSYSDIVGGATAIGEQPIKSLLNPAAGARLAVAEALTNLLFAQVTDLKDVKCSGNWMWAAKLPGEGALLYDACAAMCDVMAQLGVAIDGGKDSLSMAARVGTET-VKAPGSLVISVYAVCPDITTTVTPDLKNPGQKGVLLYLPLCPGQHRLGGSALAQCYSQLGETPPDLDDPQTLISCFNVTQQLLRDRVLSAGHDVSDGGLVTCILEMAFAGNCGLDIEISSSCTNV--------LELLFAEEPGLVLEVAEQSVELVMERYRAAGVECVRIGCTKERGPAS-MVRIRANGQEVV-NEKLGSLRAVWEETSFQLERLQANPSCVSQEEAGLRVREGPSYHLTFNPSEIP---LVPPS-VGGNQPRVAVVREEGSNGDREMAASLLMAGFQVWDVTMEDLLAGGTTLDSFRGLVFVGGFSYADVLGSAKGWAASVKFNASVREQFENFRRRADTFSLGVCNGCQLMALLGWVGPDNPTDTGDLPTQGVLLSHNLSGRFESRFVTLKI-QQSPSILLRGMAGSTLGVWVAHGEGYMRFRSPKVQDYVTSNHLAPLCYV--DDGGKPTEEYPMNPNGSPLGIAGLCSADGRHLAMMPHPERCVMKWQWPWMPESWRHSLDVSPWMRLFQNGYRWCQE 1286
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Xenopus
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:100216263]) HSP 1 Score: 1250.73 bits (3235), Expect = 0.000e+0 Identity = 676/1283 (52.69%), Postives = 871/1283 (67.89%), Query Frame = 2
Query: 287 NINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPS----MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGS---LIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNP--NITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCE--MKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVEK 4087
+I+D SS + ++ +EIGPRLNF T STNAV I +S+G + R E S Y N + S+ +++ +++D+MTE YP + SF ++V P V+ +DI+ +G ALE+ N +GLA D WDL YY +F + RNPS+VECFDLAQSNSEHSRHWFFKG++ +DG E E SLFD++ +TQ SN NNVI F DNSSAI+G L DP+ Y + S +++ FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G G +V+AGTAGYCFGNL +P Y+LPWE D ++YP FA+ ++ IEASNGASDYGN+FGEPV+ GF RSFG+ SGE +EW+KPIMFSGGIG + +H K +P V+K+GGPVYRIGVGGGAASS+++QGD++ ELD GAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I +F LGDPT+++LE+WGAEYQESN LL+ + + +C RER P++ VGK+TGDG I LIN + D + +P VDL L VLGKMP+K+F L V L PL LP L V AL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+V+LSY DIVG ATAIGEQPIK L+N GA+L V EALTNL VT +D+K SGNWMW AKLPGEGA L+DAC A C ++ L +AIDGGKDSLSMAA V T VK+PGSLV+S Y CPDI VTPDLK G L+++ + Q+RLGGSALAQ Y QLG+ P+ D+ +N Q++ +++ SA HD+SDGGL+ C+LEMAFAGN G+D+ I++S + + +LF EE G ++EV + V+ + + IG + +R + V + N + N KLG R +WE+TS+ LE+LQ N CV++E + P ++T NP S+ L P + + RVA++REEGSNGDREMAA+ + +GF+ WD+TM+DLL+ TL+ F GL+FVGGFS+ DVLGSAKGWAA++K+N ++++F+NF+ R DTFSLGVCNGCQLM LGW+ + D + ++LSHN S RFESRF + I Q + SI+L + G+ LGVWVAHGEG F + + S+ L L YV D YP NPNGS +AGLCS DGRHLA+MPHPER M WQW + + S +VSPWM +F + Y W ++
Sbjct: 49 SISDTSS----LHSEPSDLLVEIGPRLNFSTATSTNAVSICRSVGLTNVDRIECSKRYLIKVGNPSG-SEEQELLASLYDRMTECVYPEPVRSFEVSVRPEKVYEVDILGQGRAALEKANTELGLAFDSWDLDYYSSLFQRV-GRNPSSVECFDLAQSNSEHSRHWFFKGKLKVDGQEKEMSLFDMIMKTQDTSNPNNVIKFCDNSSAIQGREVASLIPTDPSCAGPYHLCRSTRHLIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSTGRGAHVIAGTAGYCFGNLHIPGYSLPWE-DLAYQYPVQFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGLRLPSGERREWVKPIMFSGGIGSMEDVHRTKEAPEPGMHVVKVGGPVYRIGVGGGAASSIQVQGDNA--SELDFGAVQRGDAEMEQKMNRAVRACVERGGKNPICSIHDQGAGGNGNVLKELSEPQGAVIYTKSFQLGDPTLSVLEIWGAEYQESNALLLRPDDAEFLRSVCRRERSPVDFVGKITGDGRIVLINGSDTDPAPDSTDRNAVP--VDLQLEWVLGKMPRKEFVLNRVAPNLQPLVLPSGLTVGQALDRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVSLSYSDIVGGATAIGEQPIKSLLNPAAGARLAVAEALTNLLFAQVTDLKDVKCSGNWMWAAKLPGEGALLYDACAAMCDVMAQLGVAIDGGKDSLSMAARVGTET-VKAPGSLVISVYAVCPDITTTVTPDLKNPGQKGVLLYLPLCPGQHRLGGSALAQCYSQLGETPPDLDDPQTLISCFNVTQQLLRDRVLSAGHDVSDGGLVTCILEMAFAGNCGLDIEISSSCTNV--------LELLFAEEPGLVLEVAEQSVELVMERYRAAGVECVRIGCTKERGPAS-MVRIRANGQEVV-NEKLGSLRAVWEETSFQLERLQANPSCVSQEEAGLRVREGPSYHLTFNP---SEIPLVPPS-VGGNQPRVAVVREEGSNGDREMAASLLMAGFQVWDVTMEDLLAGGTTLDSFRGLVFVGGFSYADVLGSAKGWAASVKFNASVREQFENFRRRADTFSLGVCNGCQLMALLGWVGPDNPTDTVGDLPTQGVLLSHNLSGRFESRFVTLKI-QQSPSILLRGMAGSTLGVWVAHGEGYMRFRSPKVQDYVTSNHLAPLCYV--DDGGKPTEEYPMNPNGSPLGIAGLCSADGRHLAMMPHPERCVMKWQWPWMPESWRHSLDVSPWMRLFQNGYRWCQE 1302
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Xenopus
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:100216263]) HSP 1 Score: 1246.49 bits (3224), Expect = 0.000e+0 Identity = 688/1356 (50.74%), Postives = 891/1356 (65.71%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITR----SDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPS----MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGS---LIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNP--NITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEM--------KRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVEK 4087
M VLHFY+ + S++ R N+ E+CYN+ G Q L + +I+D SS + ++ +EIGPRLNF T STNAV I +S+G + R E S Y + S+ +++ +++D+MTE YP + SF ++V P V+ +DI+ +G ALE+ N +GLA D WDL YY +F + RNPS+VECFDLAQSNS RHWFFKG++ +DG E E SLFD++ +TQ SN NNVI F DNSSAI+G L DP+ Y + S +++ FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G G +V+AGTAGYCFGNL +P Y+LPWE D ++YP FA+ ++ IEASNGASDYGN+FGEPV+ GF RSFG+ SGE +EW+KPIMFSGGIG + +H K +P V+K+GGPVYRIGVGGGAASS+++QGD++ ELD GAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I +F LGDPT+++LE+WGAEYQESN LL+ + + +C RER P++ VGK+TGDG I LIN + D + +P VDL L VLGKMP+K+F L V L PL LP L V AL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+V+LSY DIVG ATAIGEQPIK L+N GA+L V EALTNL VT +D+K SGNWMW AKLPGEGA L+DAC A C ++ L +AIDGGKDSLSMAA V T VK+PGSLV+S Y CPDI VTPDLK G L+++ + Q+RLGGSALAQ Y QLG+ P+ D+ +N Q++ +++ SA HD+SDGGL+ C+LEMAFAGN G+D+ I++S + + +LF EE G ++EV + V+ + + IG + +R + V + N + N KLG R +WE+TS+ LE+LQ N CV++E + P ++T NP I L P + + RVA++REEGSNGDREMAA+ + +GF+ WD+TM+DLL+ TL+ F GL+FVGGFS+ DVLGSAKGWAA++K+N ++++F+NF+ R DTFSLGVCNGCQLM LGW+ + D + + ++LSHN S RFESRF + I Q + SI+L + G+ LGVWVAHGEG F + + S+ L L YV D YP NPNGS +AGLCS DGRHLA+MPHPER M WQW + + S +VSPWM +F + Y W ++
Sbjct: 25 MVVLHFYRSLQNSSETLRLPGAENIQS----LQRELCYNVNWTGPAAPSSQETDALRWLFSCPFDPQSISDTSS----LHSEPSDLLVEIGPRLNFSTATSTNAVSICRSVGLTNVDRIECSKRYLIKFQTRPQGSEEQELLASLYDRMTECVYPEPVRSFEVSVRPEKVYEVDILGQGRAALEKANTELGLAFDSWDLDYYSSLFQRV-GRNPSSVECFDLAQSNS---RHWFFKGKLKVDGQEKEMSLFDMIMKTQDTSNPNNVIKFCDNSSAIQGREVASLIPTDPSCAGPYHLCRSTRHLIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSTGRGAHVIAGTAGYCFGNLHIPGYSLPWE-DLAYQYPVQFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGLRLPSGERREWVKPIMFSGGIGSMEDVHRTKEAPEPGMHVVKVGGPVYRIGVGGGAASSIQVQGDNA--SELDFGAVQRGDAEMEQKMNRAVRACVERGGKNPICSIHDQGAGGNGNVLKELSEPQGAVIYTKSFQLGDPTLSVLEIWGAEYQESNALLLRPDDAEFLRSVCRRERSPVDFVGKITGDGRIVLINGSDTDPAPDSTDRNAVP--VDLQLEWVLGKMPRKEFVLNRVAPNLQPLVLPSGLTVGQALDRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVSLSYSDIVGGATAIGEQPIKSLLNPAAGARLAVAEALTNLLFAQVTDLKDVKCSGNWMWAAKLPGEGALLYDACAAMCDVMAQLGVAIDGGKDSLSMAARVGTET-VKAPGSLVISVYAVCPDITTTVTPDLKNPGQKGVLLYLPLCPGQHRLGGSALAQCYSQLGETPPDLDDPQTLISCFNVTQQLLRDRVLSAGHDVSDGGLVTCILEMAFAGNCGLDIEISSSCTNV--------LELLFAEEPGLVLEVAEQSVELVMERYRAAGVECVRIGCTKERGPAS-MVRIRANGQEVV-NEKLGSLRAVWEETSFQLERLQANPSCVSQEEAGLRVREGPSYHLTFNPSEIP---LVPPS-VGGNQPRVAVVREEGSNGDREMAASLLMAGFQVWDVTMEDLLAGGTTLDSFRGLVFVGGFSYADVLGSAKGWAASVKFNASVREQFENFRRRADTFSLGVCNGCQLMALLGWVGPDNPTDTGKYVFPVGDLPTQGVLLSHNLSGRFESRFVTLKI-QQSPSILLRGMAGSTLGVWVAHGEGYMRFRSPKVQDYVTSNHLAPLCYV--DDGGKPTEEYPMNPNGSPLGIAGLCSADGRHLAMMPHPERCVMKWQWPWMPESWRHSLDVSPWMRLFQNGYRWCQE 1345
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Xenopus
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:100216263]) HSP 1 Score: 1242.25 bits (3213), Expect = 0.000e+0 Identity = 673/1293 (52.05%), Postives = 870/1293 (67.29%), Query Frame = 2
Query: 287 NINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIR--------LINSVALEEELDP------SMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGS---LIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNP--NITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCE--MKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVEK 4087
+I+D SS + ++ +EIGPRLNF T STNAV I +S+G + R E S Y S+ +++ +++D+MTE YP + SF ++V P V+ +DI+ +G ALE+ N +GLA D WDL YY +F + RNPS+VECFDLAQSNSEHSRHWFFKG++ +DG E E SLFD++ +TQ SN NNVI F DNSSAI+G L DP+ Y + S +++ FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G G +V+AGTAGYCFGNL +P Y+LPWE D ++YP FA+ ++ IEASNGASDYGN+FGEPV+ GF RSFG+ SGE +EW+KPIMFSGGIG + +H K +P V+K+GGPVYRIGVGGGAASS+++QGD++ ELD GAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I +F LGDPT+++LE+WGAEYQESN LL+ + + +C RER P++ VGK+TGDG + IN ++ + P ++P VDL L VLGKMP+K+F L V L PL LP L V AL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+V+LSY DIVG ATAIGEQPIK L+N GA+L V EALTNL VT +D+K SGNWMW AKLPGEGA L+DAC A C ++ L +AIDGGKDSLSMAA V T VK+PGSLV+S Y CPDI VTPDLK G L+++ + Q+RLGGSALAQ Y QLG+ P+ D+ +N Q++ +++ SA HD+SDGGL+ C+LEMAFAGN G+D+ I++S+ + +LF EE G ++EV + V+ + + IG + +R + V + N + N KLG R +WE+TS+ LE+LQ N CV++E + P ++T NP S+ L P + + RVA++REEGSNGDREMAA+ + +GF+ WD+TM+DLL+ TL+ F GL+FVGGFS+ DVLGSAKGWAA++K+N ++++F+NF+ R DTFSLGVCNGCQLM LGW+ + D + ++LSHN S RFESRF + I Q + SI+L + G+ LGVWVAHGEG F + + S+ L L YV D YP NPNGS +AGLCS DGRHLA+MPHPER M WQW + + S +VSPWM +F + Y W ++
Sbjct: 59 SISDTSS----LHSEPSDLLVEIGPRLNFSTATSTNAVSICRSVGLTNVDRIECSKRYLIKG------SEEQELLASLYDRMTECVYPEPVRSFEVSVRPEKVYEVDILGQGRAALEKANTELGLAFDSWDLDYYSSLFQRV-GRNPSSVECFDLAQSNSEHSRHWFFKGKLKVDGQEKEMSLFDMIMKTQDTSNPNNVIKFCDNSSAIQGREVASLIPTDPSCAGPYHLCRSTRHLIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSTGRGAHVIAGTAGYCFGNLHIPGYSLPWE-DLAYQYPVQFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGLRLPSGERREWVKPIMFSGGIGSMEDVHRTKEAPEPGMHVVKVGGPVYRIGVGGGAASSIQVQGDNA--SELDFGAVQRGDAEMEQKMNRAVRACVERGGKNPICSIHDQGAGGNGNVLKELSEPQGAVIYTKSFQLGDPTLSVLEIWGAEYQESNALLLRPDDAEFLRSVCRRERSPVDFVGKITGDGRVTAQEQICPVFINDPPIDTDPAPDSTDRNAVP--VDLQLEWVLGKMPRKEFVLNRVAPNLQPLVLPSGLTVGQALDRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVSLSYSDIVGGATAIGEQPIKSLLNPAAGARLAVAEALTNLLFAQVTDLKDVKCSGNWMWAAKLPGEGALLYDACAAMCDVMAQLGVAIDGGKDSLSMAARVGTET-VKAPGSLVISVYAVCPDITTTVTPDLKNPGQKGVLLYLPLCPGQHRLGGSALAQCYSQLGETPPDLDDPQTLISCFNVTQQLLRDRVLSAGHDVSDGGLVTCILEMAFAGNCGLDIEISSSL-----------LELLFAEEPGLVLEVAEQSVELVMERYRAAGVECVRIGCTKERGPAS-MVRIRANGQEVV-NEKLGSLRAVWEETSFQLERLQANPSCVSQEEAGLRVREGPSYHLTFNP---SEIPLVPPS-VGGNQPRVAVVREEGSNGDREMAASLLMAGFQVWDVTMEDLLAGGTTLDSFRGLVFVGGFSYADVLGSAKGWAASVKFNASVREQFENFRRRADTFSLGVCNGCQLMALLGWVGPDNPTDTVGDLPTQGVLLSHNLSGRFESRFVTLKI-QQSPSILLRGMAGSTLGVWVAHGEGYMRFRSPKVQDYVTSNHLAPLCYV--DDGGKPTEEYPMNPNGSPLGIAGLCSADGRHLAMMPHPERCVMKWQWPWMPESWRHSLDVSPWMRLFQNGYRWCQE 1314
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Mouse
Match: Pfas (phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) [Source:MGI Symbol;Acc:MGI:2684864]) HSP 1 Score: 1198.73 bits (3100), Expect = 0.000e+0 Identity = 673/1362 (49.41%), Postives = 868/1362 (63.73%), Query Frame = 2
Query: 104 VLHFYQIVS-----FSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPV-FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVAL--------EEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPT--VTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYG---NPNITSNP-FVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRD-------IILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWVEKL*C 4096
VLHFY S S ++ R L + L +E+CYN+ + L + + L + + D ++ ++ +E+GPRLNF TP STN V + ++ G + R E + Y S + + +HD+MTE YP I SF+ P+P+ +IDI+ EG ALE+ N+ +GLA+D WDL +Y F + RNPS VE FDLAQSNSEHSRHWFFKGQ+ +DG ++ SLF+ + TQ SN NNV+ F DNSSAI+G L D PS ++ + ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q G G +VVAGTAGYCFGNL +P Y LPWE DP F+YP NFA+ ++ IEASNGASDYGN+FGEPV+ GF RS G+ G+ +EWIKPIMFSGGIG + + HV K P V+K+GGPVYRIGVGGGAASSV++QGD++ D LD GAVQRGD +ME KMNRVIR C++ NPI S+HDQGAGGNGNVLKEL DP GAII S F LGDPT+N LE+WGAEYQESN LL+ D + RERCP VG +TGD I L++ + L P P VDLDL VLGKMP+K+F+L+ +L PL LP L V AL+RVLRLP+V SKR+LTNKVDRSV GLVAQQQCVGPL TPLADVA+VALS+ + +GAATA+GEQP+K L++ K A+L V EALTNL VT D+K SGNWMW AKLPGEGAAL DAC A +++ L +A+DGGKDSLSMAA V T V++PGSLV+SAY CPDI VTPDLK G G L+++ ++ Q+RLGG+ALAQ + QLG+ P+ D ++++ Q + E + HD+SDGGL+ CLLEMAFAGN GI+V D A A + +LF EE G ++EV ++ V ES L +GH+ E P ++VN+ + +GE R +WE+TS+ L+ LQ CV +E Q P+ P F ++ KP V RVAILREEGSNGDREMA AF +GFE WD+TMQDL S I L+ F G+ FVGGFS+ DVLGSAKGWAAA+ +N + +++ F+ R DTFSLGVCNGCQL+ LGW+ S + E +D ++L HN S RFESR++ V + + ++ML + G+ L VW AHGEG F++ E ++ + GL+ L++ + D + YP NPNGS +AG+CS+DGRHLA+MPHPER+ WQWA+ SPW+ +F +A W ++ C
Sbjct: 4 VLHFYVRPSGHEGAASGRVFRRLQEK--LPTLQSVETELCYNVHWAAETLPWAEEMKKLMWLFGCPLVRDDVAQEPWLVPGSNDLLLEVGPRLNFSTPASTNIVSVCQAAGLRAVDRVETTRRYRLSFTDHPTAEMEAISLAALHDRMTEQHYPDPIQSFSPQSIPAPLKGSIDILAEGRPALEKANQELGLALDSWDLDFYTKRFQE-LQRNPSTVEVFDLAQSNSEHSRHWFFKGQLHVDGKKLAHSLFESIMSTQASSNPNNVLKFCDNSSAIQGKKVKFLRPEDSTRPSCFQQQQGLRHVVFTAETHNFPTGVAPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPDYNLPWE-DPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEAKHVGKKPPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSD--LDFGAVQRGDPEMEQKMNRVIRACVEAPGGNPICSLHDQGAGGNGNVLKELSDPEGAIIYTSRFQLGDPTLNALEIWGAEYQESNALLLRPSDRDFLSRASARERCPACFVGTITGDKRIVLVDDRECLVGKTGQGDAPLTPPTP--VDLDLDWVLGKMPQKEFFLQRKPPVLQPLALPPELSVRQALNRVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHQECIGAATALGEQPVKSLLDPKAAARLAVSEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGTET-VQAPGSLVISAYAVCPDITATVTPDLKHPGGKGHLLYVPLSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFHITQGLLKECRLCSGHDVSDGGLVTCLLEMAFAGNCGIEV-------DVPAPGIHA-LPVLFAEEPGLVLEVQEADVAGVRQRYESAGLRCLELGHTG---EAGPQAMARISVNKAVVVEE-PVGELRALWEETSFQLDLLQAEPRCVIEEKQGLKERTGPSYYLPPTFPVASVPCKP----GGPVPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIRLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFNPQAREELGRFRRRPDTFSLGVCNGCQLLALLGWVGSDPSEEQAEPGQDSQPTQPGLLLRHNLSGRFESRWATVRV-EPGPALMLRGMEGSVLPVWSAHGEGYMAFSSPELQAKIEAKGLVPLHWADDDGNPTE--QYPLNPNGSPGGIAGICSQDGRHLALMPHPERAVRLWQWAWRPSPFDVLPTSPWLQLFINARNWTQEDSC 1337
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Mouse
Match: Pfas (phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) [Source:MGI Symbol;Acc:MGI:2684864]) HSP 1 Score: 339.347 bits (869), Expect = 1.452e-103 Identity = 195/483 (40.37%), Postives = 268/483 (55.49%), Query Frame = 2
Query: 2780 AAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTV--TLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYG---NPNITSNP-FVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRD-------IILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGK-------------------------------FEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWVEKL*C 4096
+ HD+SDGGL+ CLLEMAFAGN GI+V D A A + +LF EE G ++EV ++ V ES L +GH+ E P ++VN+ + +GE R +WE+TS+ L+ LQ CV +E Q P+ P F ++ KP V RVAILREEGSNGDREMA AF +GFE WD+TMQDL S I L+ F G+ FVGGFS+ DVLGSAKGWAAA+ +N + +++ F+ R DTFSLGVCNGCQL+ LGW+ S + E +D ++L HN S RFESR++ V + + ++ML + G+ L VW AHGEG+ F++ E ++ + GL+ L++ + D + YP NPNGS +AG+CS+DGRHLA+MPHPER+ WQWA+ SPW+ +F +A W ++ C
Sbjct: 10 SGHDVSDGGLVTCLLEMAFAGNCGIEV-------DVPAPGIHA-LPVLFAEEPGLVLEVQEADVAGVRQRYESAGLRCLELGHTG---EAGPQAMARISVNKAVVVEE-PVGELRALWEETSFQLDLLQAEPRCVIEEKQGLKERTGPSYYLPPTFPVASVPCKP----GGPVPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIRLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFNPQAREELGRFRRRPDTFSLGVCNGCQLLALLGWVGSDPSEEQAEPGQDSQPTQPGLLLRHNLSGRFESRWATVRV-EPGPALMLRGMEGSVLPVWSAHGEGQAGKAGEGLQAGAGAGPEGTWPSLSSPSLPGYMAFSSPELQAKIEAKGLVPLHWADDDGNPTE--QYPLNPNGSPGGIAGICSQDGRHLALMPHPERAVRLWQWAWRPSPFDVLPTSPWLQLFINARNWTQEDSC 473
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Mouse
Match: Pfas (phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) [Source:MGI Symbol;Acc:MGI:2684864]) HSP 1 Score: 108.227 bits (269), Expect = 4.372e-27 Identity = 55/82 (67.07%), Postives = 64/82 (78.05%), Query Frame = 2
Query: 1481 AASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTL 1726
AASSV++QGD++ D LD GAVQRGD +ME KMNRVIR C++ NPI S+HDQGAGGNGNVLKEL DP GAII S F +
Sbjct: 20 AASSVQVQGDNTSD--LDFGAVQRGDPEMEQKMNRVIRACVEAPGGNPICSLHDQGAGGNGNVLKELSDPEGAIIYTSRFQI 99
BLAST of Phosphoribosylformylglycinamidine synthase vs. UniProt/SwissProt
Match: sp|Q5SUR0|PUR4_MOUSE (Phosphoribosylformylglycinamidine synthase OS=Mus musculus OX=10090 GN=Pfas PE=1 SV=1) HSP 1 Score: 1198.73 bits (3100), Expect = 0.000e+0 Identity = 673/1362 (49.41%), Postives = 868/1362 (63.73%), Query Frame = 2
Query: 104 VLHFYQIVS-----FSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPV-FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVAL--------EEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPT--VTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYG---NPNITSNP-FVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRD-------IILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWVEKL*C 4096
VLHFY S S ++ R L + L +E+CYN+ + L + + L + + D ++ ++ +E+GPRLNF TP STN V + ++ G + R E + Y S + + +HD+MTE YP I SF+ P+P+ +IDI+ EG ALE+ N+ +GLA+D WDL +Y F + RNPS VE FDLAQSNSEHSRHWFFKGQ+ +DG ++ SLF+ + TQ SN NNV+ F DNSSAI+G L D PS ++ + ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q G G +VVAGTAGYCFGNL +P Y LPWE DP F+YP NFA+ ++ IEASNGASDYGN+FGEPV+ GF RS G+ G+ +EWIKPIMFSGGIG + + HV K P V+K+GGPVYRIGVGGGAASSV++QGD++ D LD GAVQRGD +ME KMNRVIR C++ NPI S+HDQGAGGNGNVLKEL DP GAII S F LGDPT+N LE+WGAEYQESN LL+ D + RERCP VG +TGD I L++ + L P P VDLDL VLGKMP+K+F+L+ +L PL LP L V AL+RVLRLP+V SKR+LTNKVDRSV GLVAQQQCVGPL TPLADVA+VALS+ + +GAATA+GEQP+K L++ K A+L V EALTNL VT D+K SGNWMW AKLPGEGAAL DAC A +++ L +A+DGGKDSLSMAA V T V++PGSLV+SAY CPDI VTPDLK G G L+++ ++ Q+RLGG+ALAQ + QLG+ P+ D ++++ Q + E + HD+SDGGL+ CLLEMAFAGN GI+V D A A + +LF EE G ++EV ++ V ES L +GH+ E P ++VN+ + +GE R +WE+TS+ L+ LQ CV +E Q P+ P F ++ KP V RVAILREEGSNGDREMA AF +GFE WD+TMQDL S I L+ F G+ FVGGFS+ DVLGSAKGWAAA+ +N + +++ F+ R DTFSLGVCNGCQL+ LGW+ S + E +D ++L HN S RFESR++ V + + ++ML + G+ L VW AHGEG F++ E ++ + GL+ L++ + D + YP NPNGS +AG+CS+DGRHLA+MPHPER+ WQWA+ SPW+ +F +A W ++ C
Sbjct: 4 VLHFYVRPSGHEGAASGRVFRRLQEK--LPTLQSVETELCYNVHWAAETLPWAEEMKKLMWLFGCPLVRDDVAQEPWLVPGSNDLLLEVGPRLNFSTPASTNIVSVCQAAGLRAVDRVETTRRYRLSFTDHPTAEMEAISLAALHDRMTEQHYPDPIQSFSPQSIPAPLKGSIDILAEGRPALEKANQELGLALDSWDLDFYTKRFQE-LQRNPSTVEVFDLAQSNSEHSRHWFFKGQLHVDGKKLAHSLFESIMSTQASSNPNNVLKFCDNSSAIQGKKVKFLRPEDSTRPSCFQQQQGLRHVVFTAETHNFPTGVAPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPDYNLPWE-DPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEAKHVGKKPPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSD--LDFGAVQRGDPEMEQKMNRVIRACVEAPGGNPICSLHDQGAGGNGNVLKELSDPEGAIIYTSRFQLGDPTLNALEIWGAEYQESNALLLRPSDRDFLSRASARERCPACFVGTITGDKRIVLVDDRECLVGKTGQGDAPLTPPTP--VDLDLDWVLGKMPQKEFFLQRKPPVLQPLALPPELSVRQALNRVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHQECIGAATALGEQPVKSLLDPKAAARLAVSEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGTET-VQAPGSLVISAYAVCPDITATVTPDLKHPGGKGHLLYVPLSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFHITQGLLKECRLCSGHDVSDGGLVTCLLEMAFAGNCGIEV-------DVPAPGIHA-LPVLFAEEPGLVLEVQEADVAGVRQRYESAGLRCLELGHTG---EAGPQAMARISVNKAVVVEE-PVGELRALWEETSFQLDLLQAEPRCVIEEKQGLKERTGPSYYLPPTFPVASVPCKP----GGPVPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIRLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFNPQAREELGRFRRRPDTFSLGVCNGCQLLALLGWVGSDPSEEQAEPGQDSQPTQPGLLLRHNLSGRFESRWATVRV-EPGPALMLRGMEGSVLPVWSAHGEGYMAFSSPELQAKIEAKGLVPLHWADDDGNPTE--QYPLNPNGSPGGIAGICSQDGRHLALMPHPERAVRLWQWAWRPSPFDVLPTSPWLQLFINARNWTQEDSC 1337
BLAST of Phosphoribosylformylglycinamidine synthase vs. UniProt/SwissProt
Match: sp|O15067|PUR4_HUMAN (Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4) HSP 1 Score: 1187.56 bits (3071), Expect = 0.000e+0 Identity = 645/1271 (50.75%), Postives = 835/1271 (65.70%), Query Frame = 2
Query: 338 NMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPV-FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVAL------EEELDPS-MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTP--TVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPY--NKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRD-------IILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWV 4081
++ +E+GPRLNF TP STN V + ++ G + R E + Y S + + +HD+MTE +PH I SF+ P P+ I+I+ EG ALE+ N+ +GLA+D WDL +Y F + RNPS VE FDLAQSNSEHSRHWFFKGQ+ +DG ++ SLF+ + TQ+ SN NNV+ F DNSSAI+G L DP PS ++ + ++V FTAETHNFPTGV PF GA TGTGGRIRD+Q G G +VVAGTAGYCFGNL +P Y LPWE DP F+YP NFA+ ++ IEASNGASDYGN+FGEPV+ GF RS G+ G+ +EWIKPIMFSGGIG + + H++K +P V+K+GGPVYRIGVGGGAASSV++QGD++ D LD GAVQRGD +ME KMNRVIR C++ NPI S+HDQGAGGNGNVLKEL DP GAII S F LGDPT+N LE+WGAEYQESN LL+ + D + RERCP VG +TGD I L++ + + P+ +P VDL+L VLGKMP+K+F+L+ +L PL LP L V AL RVLRLP+V SKR+LTNKVDRSV GLVAQQQCVGPL TPLADVA+VALS+ +++GAATA+GEQP+K L++ K A+L V EALTNL VT D+K SGNWMW AKLPGEGAAL DAC A +++ L +A+DGGKDSLSMAA V T V++PGSLV+SAY CPDI VTPDLK G G L+++ ++ Q+RLGG+ALAQ + QLG+ P+ D ++++ Q + ++L + HD+SDGGL+ CLLEMAFAGN G+ V + +S+LF EE G ++EV L+ V+ L +GH+ E P V ++VN + +GE R +WE+TS+ L++LQ CV +E + G + + ++ K + RVAILREEGSNGDREMA AF +GFE WD+TMQDL S I L+ F G+ FVGGFS+ DVLGSAKGWAAA+ ++ + + + F+ R DTFSLGVCNGCQL+ LGW+ + D EM D ++L HN S R+ESR++ V + ++ML + GA L VW AHGEG F++ E +Q + GL L++ + D + YP NPNGS VAG+CS DGRHLA+MPHPER+ WQWA+ + SPW+ +F +A W
Sbjct: 85 DLLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVETTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSFSPESMPEPLNGPINILGEGRLALEKANQELGLALDSWDLDFYTKRFQE-LQRNPSTVEAFDLAQSNSEHSRHWFFKGQLHVDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQGLRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGYNLPWE-DPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSD--LDFGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTSRFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVLVDDRECPVRRNGQGDAPPTPLPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLSVHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIGAATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGTET-VRAPGSLVISAYAVCPDITATVTPDLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLKDRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDV--------PVPRVDVLSVLFAEEPGLVLEVQEPDLAQVLKRYRDAGLHCLELGHTG---EAGPHAMVRVSVNGAVVLEE-PVGELRALWEETSFQLDRLQAEPRCVAEEER--GLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAGAELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSGRYESRWASVRV-GPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWADDDGNPTE--QYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTSPWLQLFINARNWT 1333
BLAST of Phosphoribosylformylglycinamidine synthase vs. UniProt/SwissProt
Match: sp|P35421|PUR4_DROME (Phosphoribosylformylglycinamidine synthase OS=Drosophila melanogaster OX=7227 GN=Pfas PE=1 SV=2) HSP 1 Score: 1115.52 bits (2884), Expect = 0.000e+0 Identity = 634/1367 (46.38%), Postives = 844/1367 (61.74%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDN-NLLDGTIIATS-EICYNIEIKGXXXXXXXXXXXXXXITRS--DNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQIN---SFNLNVAPSPV--FTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPC-FKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGM--ITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDP--LGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVA---LEEELDPSMPYIV---DLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDG-----SLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSA------EISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEY---QFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG---DLDVSTEVSPWMCIFNSAYEWVEK 4087
M +L +Y + + S + +++ DG +++ E CY++E L LL + + +S +P + +EIGPR NF TP STN V I ++LG++ + R E S Y + + + + + D+MT+ Y + SF+ + + ++ EG ALE IN+ +GLA +++DL YYHD+F + RNP+ VE FD AQSNSEHSRHWFF+G+M+IDGVE +SL ++ +TQ ++N NN I FSDNSSA+ GF + + P ++ ++ FTAETHN PT VAPF GA TGTGGR+RD+Q VG GG +AGTAGYC G L +P Y P+E P FKYP+ FA +++IEASNGASDYGN+FGEPVI+GF S+G+ + + E++KPIMFSGG+G + + K P QL+ KIGGPVYRIGVGGGAASSVEIQG S D ELD AVQRGDA+MENK+NRV+R C+DL + NPI +IHDQGAGGNGNVLKELV+P GA+I + F LGDPTI LELWGAEYQE+N +L + + +KIC RERCPI+ VG VTGDG + L+ A LE+ L+ S V DL+L VLG MPK+ + LK + L L LP L +++AL RVL L +VGSKRFLTNKVDR V GL+AQQQCVGPL PLAD A+ +S+F G AT+IG QP+K L++ A++CV EAL+NL + ++ D+K SGNWMW AKLPGEGA ++DAC C +L++L IAIDGGKDSLSMAA V T +KSPG+LV+S Y CPD+RL VTPDLKG G SL+WI + + RLGGSALAQ Y Q G P + K++ Q + + L A HD+SDGGL+ C+LEMA G G+ V ++ +A + S E+++LF EE GW++EV + L V + E + +G + + + + V L + + L WE TSY LEKLQ N EC EY ++ P V ++ L K +S RVA+LREEG N +REM A +++ FE D+TM DLL ++ ++ GLIF GGFS+ D LGSAKGWAA I +N ++ +F+ FK R+D FSLG+CNGCQLMT +G++ + S D+ L HN S RFE R++ V IP N +SIML + LG WVAHGEG+F F +++ S S+ L+ L YV D YP NPNGS +AGLCS DGRHLA+MPHPER +QW Y ++ + SPW +FN+AY W K
Sbjct: 1 MVILRYYDVQAHSAAEEESVLRRLREEDGAVVSVRMERCYHLEYSAQAEHSLALDELLVWLVKQPLSKGQSLSRQPALQSTGSSQLLLEIGPRFNFSTPYSTNCVNIFQNLGYSEVRRMETSTRYLVTFGEGSKAPEAARFVPLLGDRMTQCLYTEENTPKASFDEQLPERQANWHFVPVLEEGRAALERINQELGLAFNDYDLDYYHDLFAKELGRNPTTVELFDCAQSNSEHSRHWFFRGRMVIDGVEQPKSLIRMIMDTQAHTNPNNTIKFSDNSSAMVGFDHQTIVPSSVVAPGAVRLQSVQSDLIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGVPIAGTAGYCVGALHIPGYKQPYE--PLDFKYPATFAPPLQVLIEASNGASDYGNKFGEPVISGFALSYGLNSAADASQRDEYVKPIMFSGGLGTMPATMREKLPPARGQLLAKIGGPVYRIGVGGGAASSVEIQG--SGDAELDFNAVQRGDAEMENKLNRVVRACLDLGEQNPILAIHDQGAGGNGNVLKELVEPGFAGAVIFSKEFQLGDPTITALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTGDGRVTLLEKPAPKDLEQALNASNRSEVSPFDLELKYVLGDMPKRTYDLKREQTPLKELSLPKGLLLDEALERVLSLVAVGSKRFLTNKVDRCVGGLIAQQQCVGPLQAPLADYALTTVSHFSHSGIATSIGTQPLKGLLDPAAMARMCVAEALSNLVFVKISELADVKCSGNWMWAAKLPGEGARMFDACKELCQILEELHIAIDGGKDSLSMAAKVGGET-IKSPGTLVISTYAPCPDVRLKVTPDLKGPGAGSKTSLLWINLENSARLGGSALAQAYAQQGKDTPNLTRSDVLGKAFAVTQSLLGDGLIQAGHDVSDGGLLVCVLEMAIGGLSGLRVDLSEPLAKLKNFDKSVEKLNRPELAVLFAEECGWVVEVLDTDLERVRSTYEKAGVPNYYLGVT-EGFGLDSRVVLKNGKSELLDQ-PLRVLYKKWERTSYELEKLQANPECAEAEYNSLEYRQAPQYRGPQNVQAELTL----KRSSAPVRVAVLREEGVNSEREMMACLLRANFEVHDVTMSDLLQGTASVSQYRGLIFPGGFSYADTLGSAKGWAANILHNPRLLPQFEAFKRRQDVFSLGICNGCQLMTLIGFVGSAKS--EVGADPDVALLHNKSQRFECRWATVKIPSN-RSIMLGSMKDLVLGCWVAHGEGRFAFRDEKLISHLQSEQLVTLQYV--DDVGKPTELYPLNPNGSPQGIAGLCSSDGRHLALMPHPERCSSMYQWPYVPSSFEVSPTQSESPWQIMFNNAYNWCVK 1351
BLAST of Phosphoribosylformylglycinamidine synthase vs. UniProt/SwissProt
Match: sp|Q9M8D3|PUR4_ARATH (Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At1g74260 PE=2 SV=3) HSP 1 Score: 1109.75 bits (2869), Expect = 0.000e+0 Identity = 640/1356 (47.20%), Postives = 848/1356 (62.54%), Query Frame = 2
Query: 101 EVLHFYQIVSFSNKLKRNL---VDNNLLDGTIIATSEICYNI--EIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVAL---EEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNPN--------ITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSH---SLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWA-YTGDLDVSTE-VSPWMCIFNSAYEWVE 4084
EV+HFY++ L V + + + T+E +NI E K + L+ +L +N+ S Q + + +E+GPRL+F T STNAV I ++ G + ++R E S Y S+ L ++ + +HD+MTE Y ++ SF NV P V + +M +G KALEEIN+ MGLA DE DL YY +F + R+P+NVE FD+AQSNSEHSRHWFF G M+IDG M++SL I+ T + + N+VI F DNSSAI+GF L P + ++ ++ FTAETHNFP VAP+PGA TG GGRIRD A G G +VVA T+GYC GNL + PWE D F+YPSN A +I+I+ASNGASDYGN+FGEP+I G+ R+FGM SG+ +EW+KPIMFS GIGQ+ H+ K P V LV+KIGGP YRIG+GGGAASS+ + G + D ELD AVQRGDA+M K+ RV+R CI++ + NPI SIHDQGAGGN NV+KE++ P GA ID +GD T+++LE+WGAEYQE + +L+ + + IC RER + V+G + G G LI+S A +E P P VDL+L VLG MPKK F + PL + + + DAL RVLRLPSV SKRFLT KVDR V+GLVAQQQ VGPL LADVA++A ++ D+ G A AIGEQPIK L++ K A+L V EALTNL VT+ D+K SGNWM+ AKL GEG+A++DA A + +L IAIDGGKDSLSMAA D VVK+PG+LV+SAYV CPDI VTPDLK DG L+ + + + RLGGSALAQV+ Q+G+ CP+ D+V K ++ +Q + E L SA HDISDGGL+ LEMAFAGN GI++ + ASN + LF+EE G ++E+ L V+ L + ++ +IG+ +P + + V+ + S K R MWEDTS+ LEKLQ CV E +F PN T+N ++ D +KP +VA++REEGSNGDREM+AAF +GFE WD+T+ DLL+ ITL++F G++FVGGFS+ DVL SAKGWAA+I++NE + +FQ F R DTFSLG+CNGCQLM LGW+ SLD + + HN+S RFE RF+ V+I +++ SIML + G+ LGVW AHGEG+ F ++ L L L Y + D + YPFN NGS +A +CS DGRHLA+MPHPER F+ WQ+ Y DV SPW+ +F +A +W+E
Sbjct: 86 EVIHFYRVPLIQESANAELLKAVQTKISNQIVSLTTEQSFNIGLESKLKDEKLSVLKWILQETYEPENLGTDSFLERKKQEGLHAVIVEVGPRLSFTTAWSTNAVSICRACGLDEVTRLERSRRYLLFSKEPLLENQIKEFAAMVHDRMTECVYTQKLVSFETNVVPEEVKYVPVMEKGRKALEEINQEMGLAFDEQDLQYYTRLFREDIKRDPTNVELFDIAQSNSEHSRHWFFAGNMVIDGKPMDKSLMQIVKSTWEANRNNSVIGFKDNSSAIRGFLVNQLRPLLPGSVCLLDVSARDLDILFTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGSFVVASTSGYCVGNLNMEGSYAPWE-DSSFQYPSNLASPLQILIDASNGASDYGNKFGEPMIQGYTRTFGMRLPSGDRREWLKPIMFSAGIGQIDHTHITKGEPEVGMLVVKIGGPAYRIGMGGGAASSM-VSGQN--DAELDFNAVQRGDAEMSQKLYRVVRACIEMGEKNPIISIHDQGAGGNCNVVKEIIYPQGAEIDIRAVVVGDHTMSVLEIWGAEYQEQDAILVKAESREILQSICKRERLSMAVIGTINGGGRCTLIDSTAAAKCSKEGLPPPPPAVDLELEKVLGDMPKKTFKFNRIAYAREPLDIAPGITLMDALKRVLRLPSVSSKRFLTTKVDRCVTGLVAQQQTVGPLQITLADVAVIAQTFTDLTGGACAIGEQPIKGLLDPKAMARLAVGEALTNLVWAKVTALSDVKASGNWMYAAKLEGEGSAMYDAAIALSEAMIELGIAIDGGKDSLSMAAHA-DGEVVKAPGNLVISAYVTCPDITKTVTPDLKLGGDDGILLHVDLAKGKRRLGGSALAQVFGQIGNDCPDLDDVPYLKNVFDGVQALIAENLVSAGHDISDGGLVVTALEMAFAGNKGINLDL--------ASNGISLFETLFSEELGLVLEISKTNLDAVMEKLRAFDVTAEIIGNVTD----SPLIEVKVDGITHLSE-KTSFLRDMWEDTSFQLEKLQRLASCVEMEKEGLKFRHEPNWKLSFIPSSTNNNYMSQD--VKP---------KVAVIREEGSNGDREMSAAFYAAGFEPWDVTVSDLLAGDITLDQFRGIVFVGGFSYADVLDSAKGWAASIRFNEPVLSQFQEFYKRPDTFSLGICNGCQLMALLGWVPGPQVGGSLDTSQPR----FVHNESGRFECRFTSVTI-KDSPSIMLKGMEGSTLGVWAAHGEGRAYFPDEGVLDHMLHSDLAPLRYCDDDGNVTEA--YPFNLNGSPLGIAAICSPDGRHLAMMPHPERCFLMWQFPWYPTSWDVEKAGPSPWLKMFQNARDWLE 1405
BLAST of Phosphoribosylformylglycinamidine synthase vs. UniProt/SwissProt
Match: sp|Q54JC8|PUR4_DICDI (Phosphoribosylformylglycinamidine synthase OS=Dictyostelium discoideum OX=44689 GN=purL PE=1 SV=1) HSP 1 Score: 1055.05 bits (2727), Expect = 0.000e+0 Identity = 623/1293 (48.18%), Postives = 810/1293 (62.65%), Query Frame = 2
Query: 353 IGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLR---DLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVED-------ALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATV----NDNTVVKSPGSLVVSAYVCCPDIRLAVTPDL----KGDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSS--AEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFS-------NFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFY----------GNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEE-FNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAY--------TGDLDVSTEVSPWMCIFNSAYEWVEKL 4090
+GPR+NF T S+NA I KS ++I R E S Y S + + + ++ IHD+MTE YP I SF+ + P V I ++ EG ALE +NK MGLA DE DL Y D+F N + RNPS+VECFD+ QSNSEHSRHWFF G++I+DG +++LF I+ T K + QN++IAFSDNSS+IKGF T +L S Y + Q + FTAETHNFPTG+APF GA TGTGGR+RD A G G VVAGT GYC GNL +P Y LPWE + YP N A KI IEASNGASDYGN+FGEPVI GF RS+G +GE +EWIKPIMFSGGIG + H+ K P + +V+K GGP YRIG+GGG+ASS+ + GD+ ELD AVQRGDA+M K+NR++R C++ NPI S+HDQGAGG GNVLKE+VDPLGA I GDPT++ +E+WGAEYQE++ LLI H D KK+ +RER PI VG VTGDG +LI D P V+L L VL KMP K F L HVEK L P LP L V D L+RVLRL SVGSKRFL NKVDR+V+GLVA+QQCVGPLHTP+++VA+++ YF GAAT+IGEQPIK I+ K A L V EALTNL +T D+K SGNWMW AKL GEG L+DA ++ +L IAIDGGKDSLSMAA +VK+PG+LVVS YV C DI L VTPDL K D ++++ + + +GGSAL QV+ Q+G+ P N L K ++ +QK+ ++L SA HD SDGGLI L+EM+ +GN G+++ ++ D S+ S + I +LF+EE G ++E+ + V++ L+ + +IG++ + +L I N KL + WE+TSY LE LQ N V E + N N+T IS K + +K +VA++REEGSNGDREMAAAF +GF+ +D+TM DLL+ I L+E F G+ FVGGFS+GDV+ SAKGWA +I++N+++ K+F +F R DTFSLG+CNGCQLM LGW+ ++ R I HN S RFESR+ V I + +++L + G+ LGVW HGEG+F +Q + ++ L + YV+ D + +YPFNP+G+ A LCSKDGRHLAIMPHPERSF+ WQW + G LD + SPW+ IF +A + + L
Sbjct: 94 VGPRMNFTTTYSSNATSICKSCNLSIIDRIERSRRYLVKSVSKLSEKQIDQFLELIHDRMTECLYPTPIKSFDTGIIPKAVVYIPVVEEGRAALERVNKEMGLAFDEQDLALYTDLFQNQLKRNPSDVECFDIGQSNSEHSRHWFFNGKLIVDGNMSDKTLFQIVKNTLKANPQNSLIAFSDNSSSIKGFKTKVLIPKSQIEASEYLEGEREQPIIFTAETHNFPTGIAPFEGAETGTGGRLRDTHATGRGSLVVAGTVGYCVGNLNIPGYELPWENKE-YNYPDNMANPLKIEIEASNGASDYGNKFGEPVIIGFTRSYGNTLPNGERREWIKPIMFSGGIGFMDERHLKKEQPEIGMVVVKAGGPAYRIGMGGGSASSM-VGGDNKH--ELDFSAVQRGDAEMGQKLNRIVRSCVESEIHGGCNPIVSVHDQGAGGAGNVLKEIVDPLGAKIYLDRIISGDPTLSAMEIWGAEYQENDALLIKAEHKDYLKKVSERERLPIAFVGDVTGDGIAQLITK-------DGETP--VNLPLDKVLQKMPPKTFVLDHVEKQLKPFTLPKELLVGDHQTCFNECLNRVLRLLSVGSKRFLINKVDRAVTGLVARQQCVGPLHTPVSNVAVISSGYFGKSGAATSIGEQPIKGFISAKSMAYLTVGEALTNLMWASITDLGDVKCSGNWMWAAKLKGEGVELYDAAIEMHDVMVELGIAIDGGKDSLSMAAKAPKSDGSQELVKAPGALVVSTYVPCDDITLTVTPDLKLSSKDDSVILYLDLGCANNFIGGSALTQVFNQVGNDEPHH-NTPLLKNTFMAIQKLVKQQLISAGHDRSDGGLITTLIEMSLSGNRGLEI----NLPDTHNSDQSPLSIIKLLFSEELGAVLEIKKSNQQIVLDILKQFNVPTQVIGNTSCNNNNNNNNNGSDEDLFIVKVGDKLIYNIKLSQLSKQWEETSYQLELLQANPTFVESEMKNLLKRATGKGKGPNYNMTYKISPIS----KELALLANKAPKVAVIREEGSNGDREMAAAFHFAGFQAFDVTMSDLLNGNIQLDERFKGVAFVGGFSYGDVMDSAKGWAGSIRFNQQVSKQFDHFYGRNDTFSLGLCNGCQLMALLGWV-PYRGIEQTHQPRFI---HNASGRFESRWVNVKI-MPSPALLLKGMEGSVLGVWSQHGEGRFWSEDQSIVNDIKANNLSPIRYVDDDG--EITESYPFNPSGTQEGFASLCSKDGRHLAIMPHPERSFLSWQWPFMPENIKQNVGGLD---QPSPWIKIFQNAKSFCDSL 1354
BLAST of Phosphoribosylformylglycinamidine synthase vs. TrEMBL
Match: A0A3B3WI83 (Phosphoribosylformylglycinamidine synthase OS=Poecilia mexicana OX=48701 PE=3 SV=1) HSP 1 Score: 1275.38 bits (3299), Expect = 0.000e+0 Identity = 687/1341 (51.23%), Postives = 888/1341 (66.22%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMS----IEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDN----LLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETD-PCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG-DLDVSTEVSPWMCIFNSAYEW 4078
M VL FY S + R L L + T+E+CYN+E+ G E + +L + R + ++P++ Q + S +EIGPRLNF T STNAV I +S G + ++R E S + +EN L + ++I+ +HD MTE Y H I SF + AP PVF +D++ +G ALE N +GLA D WDL YY +F I +RNP++VECFDLAQSNSEHSRHWFF+G+M+IDG E +LF ++ +TQ++SNQNNVI F DNSS I+G +Y DP+ S YE + S ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P Y+LPWE + ++YPS+FA ++ IEAS+GASDYGN+FGEPV++GF RSFGM +GE +EWIKPIMFSGG+G + +V K V+KIGGPVYRIGVGGGAASSV++QGD+ ++ DLGAVQRGDA+ME KMNR +R C++ + NPI SIHDQGAGGNGNVLKEL +P GA+I S F GDPT+++LELWGAEYQESN LL+ +++C RE+CP++ VG++TGDG I L++ + + + + VDL L VLGKMP+K+F ++ + L PL LP L V DAL RVLRLP+V SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+VALS F + GAATAIGEQP+K L+ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA LWDAC A C ++ L +AIDGGKDSLSMAA V T VK+PG+LV+SAY CPDI VTPDL+ G G L+W+ ++ ++RLGGSALAQ Y QLGD CP+ D + QK+ ++L SA HDISDGGL+ CLLEMAFAGN G DV ++ S+ S + +LF+EE G ++EV L V L IG +C + TV + V+ + S L + R +WE TS+ LE+LQ + CV +E + S ++ + + RVA++REEGSNGDREM+ + +GFE WD+TMQDL S +TL+ F ++FVGGFS+ DVLGSAKGWAA + YN K K +F+ F+ REDT SLGVCNGCQL+T LGW+ + + E ++L+HN S RFESRF V I Q++ SI L + G+ LGVWVAHGEG F + S GL + Y LD YP NPNGS +AGLCS+DGRHLA+MPHPER + WQW + DL + SPW+ +F +A W
Sbjct: 1 MAVLRFY---SGEALIGRALQRAAKLFPHLSITTELCYNVELTGCERLDAAQTEVLLWLFRPP----LQAEPLSDQPRLTEGSGDKLVEIGPRLNFSTAWSTNAVSICQSAGLSNVTRVERSRRFLIKAENGRSAGELSTDVKELIECLHDSMTECVYQHPITSFAVETAPQPVFEVDVLGKGCAALETANSELGLAFDSWDLDYYTSMFQRI-NRNPTSVECFDLAQSNSEHSRHWFFRGRMVIDGQEQPATLFSLIMDTQRHSNQNNVIKFCDNSSGIRGGELRCIYPADPSEASPYETRRSVRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGRGGHVIAGTAGYCFGNLHIPGYSLPWEQEGEGWEYPSSFAPPLQVAIEASDGASDYGNKFGEPVLSGFARSFGMRLANGERREWIKPIMFSGGLGSIEDNYVKKEEAEAGMEVVKIGGPVYRIGVGGGAASSVQVQGDNCSER--DLGAVQRGDAEMEQKMNRALRACLERSNGNPICSIHDQGAGGNGNVLKELSEPAGAVIYCSKFKKGDPTLSVLELWGAEYQESNALLLRPSDKSYLQRVCQREKCPVDFVGRITGDGKIVLVDDEGSDGDRADGVRHPVDLQLEWVLGKMPQKEFRMERLAPTLLPLSLPAELTVRDALQRVLRLPAVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSPFGLQGAATAIGEQPVKGLVCPAAGARMAVGEALTNLLFARVTALKDVKCSGNWMWAAKLPGEGACLWDACKAMCEVMGQLGVAIDGGKDSLSMAARVGTET-VKAPGALVISAYAVCPDITATVTPDLEDPDGKGVLLWVPVSPGRHRLGGSALAQCYSQLGDVCPDLDRPEFLSACFTTTQKLIEDRLLSAGHDISDGGLVSCLLEMAFAGNRGFDVELS--------SDGSGVMELLFSEELGLVLEVSQTDLEAVCQRYRDGGLRCHRIGRTCG-FGPEATVRVRVDGQEVLSE-SLPDLRAVWEATSFQLERLQADELCVKQEEEGLSKRTQPYFKLTFDPSETPSIRQLAAGLPRVAVVREEGSNGDREMSVSLFMAGFEVWDVTMQDLCSGSVTLQPFKAVVFVGGFSYADVLGSAKGWAATVAYNPKAKAEFERFQRREDTLSLGVCNGCQLLTLLGWVGEGEEGADSE----VVLTHNRSGRFESRFVSVGI-QSSPSIWLRGMEGSALGVWVAHGEGLMRFRSPWAQDLITSSGLAPVRY--LDDQGSPTEEYPLNPNGSPQGIAGLCSRDGRHLAMMPHPERCTLGWQWPWAPRDLRPALSPSPWLRMFRNAAAW 1313
BLAST of Phosphoribosylformylglycinamidine synthase vs. TrEMBL
Match: A0A3B5R4I6 (Phosphoribosylformylglycinamidine synthase OS=Xiphophorus maculatus OX=8083 PE=3 SV=1) HSP 1 Score: 1274.61 bits (3297), Expect = 0.000e+0 Identity = 692/1345 (51.45%), Postives = 885/1345 (65.80%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMS----IEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNI----HDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETD-PCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG-DLDVSTEVSPWMCIFNSAYEWVEKL 4090
M VL FY S + R L L + T+E+CYN+E+ G E + + + +L + R + ++P++ Q + S +EIGPRLNF T STNAV I +S G I+R E S + +EN +S+ IK + HD MTE Y H I SF + P PVF +DI+ +G ALE N+ +GLA D WDL YY +F I +RNP++VECFDLAQSNSEHSRHWFF+G+M+IDG E + +LF ++ +TQ++SNQNNVI F DNSS I+G +Y DP+ S YE + S ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+VVAGTAGYCFGNL +P Y+LPWE + ++YPS+FA ++ IEAS+GASDYGN+FGEPV++GF RSFGM +GE +EWIKPIMFSGG+G + +V K V+KIGGPVYRIGVGGGAASSV++QGD+ ++ DLGAVQRGDA+ME KMNR +R C++ + NPI SIHDQGAGGNGNVLKEL +P GA+I F GDPT+++LELWGAEYQESN LL+ +++C RE+CP++ VG +TGDG I L+N + + + + VDL L VLGKMP+K+F ++ + L PL LP L V DAL RVLRLP+V SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+VA+S F + GAATAIGEQP+K L+ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA LW+AC A C ++ L +AIDGGKDSLSMAA V T VK+PG+LV+SAY CPDI VTPDL+ G G L+W+ ++ +RLGGSALAQ Y QLGD CP+ D + QK+ ++L SA HDISDGGLI CLLEMAFAGN G DV + S+ S + +LF+EE G ++EV L V L IG +C + TV + V+E + S L R +WE TS+ LE+LQ + +CV +E + S + ++ + + RVA++REEGSNGDREM+ + +GFE WD+TMQDL S +TL+ F ++FVGGFS+ DVLGSAKGWAA + YN K K +F+ F+ REDT SLGVCNGCQL+ LGW+ + E ++L+HN S RFESRF V I Q + SI L + G+ LGVWVAHGEG F + S GL + Y LD YP NPNGS +AGLCSKDGRHLA+MPHPER + WQW + DL + SPWM +F +A W L
Sbjct: 1 MAVLRFY---SSEALIGRALQRAAKLFPHLSITTELCYNVELTGCERLDAEQKEVLLWLFRPP----LQAEPLSDQPRLTEGSGDKLVEIGPRLNFSTAWSTNAVSICQSAGLANITRVEQSRRFLIKAENGRSMSELGADIKELVGCLHDSMTECVYQHPITSFAVETTPQPVFEVDILGKGRAALETANRELGLAFDSWDLDYYTSMFQRI-NRNPTSVECFDLAQSNSEHSRHWFFRGRMVIDGQEQQATLFSLIMDTQRHSNQNNVIKFCDNSSGIRGGELRCIYPADPSEASPYETRRSLRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGRGGHVVAGTAGYCFGNLHIPGYSLPWEQEGEGWEYPSSFAPPLQVAIEASDGASDYGNKFGEPVLSGFARSFGMRLANGERREWIKPIMFSGGLGSIEDGYVKKEEAEAGMEVVKIGGPVYRIGVGGGAASSVQVQGDNCSER--DLGAVQRGDAEMEQKMNRALRACLERSNGNPICSIHDQGAGGNGNVLKELSEPAGAVIYCGKFKKGDPTLSVLELWGAEYQESNALLLRPSDKSYLERVCQREKCPVDFVGLITGDGKIVLVNDEGSDGDRADGVRHPVDLQLEWVLGKMPQKEFQMERLAPTLRPLSLPAELTVRDALQRVLRLPAVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVAMSPFGLQGAATAIGEQPVKGLVCPAAGARMAVGEALTNLLFARVTALKDVKCSGNWMWAAKLPGEGACLWEACKAMCEVMGQLGVAIDGGKDSLSMAARVGTET-VKAPGALVISAYAVCPDITATVTPDLEDPDGKGVLLWVPVSPGHHRLGGSALAQCYSQLGDVCPDLDQPEFLIACFTTTQKLIEDRLLSAGHDISDGGLISCLLEMAFAGNRGFDVEL--------PSDGSGVMELLFSEELGLVLEVSQTDLEAVCQRYRDGGLRCHRIGRTCG-FGPEATVRVRVDEQEVLSE-SLPVLRAVWEATSFQLERLQADEQCVKQEEEGLSKRTQPYFNLTFDPSEIPSIRQLAAGLPRVAVIREEGSNGDREMSVSLFMAGFEVWDVTMQDLCSGSLTLKPFKAVVFVGGFSYADVLGSAKGWAATVAYNPKAKAEFERFQRREDTLSLGVCNGCQLLALLGWVGGGEEGADSE----VVLTHNRSGRFESRFVSVGI-QKSPSIWLRGMEGSALGVWVAHGEGLMRFCSPRAQDLITSSGLAPVRY--LDDQGSPTEEYPLNPNGSPQGIAGLCSKDGRHLAMMPHPERCTLGWQWPWAPRDLRPALSPSPWMRMFRNAAAWCSNL 1317
BLAST of Phosphoribosylformylglycinamidine synthase vs. TrEMBL
Match: A0A3Q1J1K8 (Phosphoribosylformylglycinamidine synthase OS=Anabas testudineus OX=64144 PE=3 SV=1) HSP 1 Score: 1266.14 bits (3275), Expect = 0.000e+0 Identity = 686/1341 (51.16%), Postives = 882/1341 (65.77%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSD-NINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNI----HDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETD-PCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG-DLDVSTEVSPWMCIFNSAYEWVEK 4087
M V+ FY + R L L + T+E+CYN+E+ G E ++ + +L + R +S KP N +EIGPRLNF T STNAV + +S G ++R E+S + ++ N +K + +D MTE Y H I SF + P PVF +DI+ G ALE N +GLA D WDL YY +F I RNP++VECFDLAQSNSEHSRHWFF+G+M+ID E +++LF ++ +TQ++SNQNNVI F DNSS IKG +Y DP+ S YE + S ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P Y LPWE + ++YPS+FA ++ IEAS+GASDYGN+FGEPV++GF RSFGM +GE +EWIKPIMFSGG+G + HV K V+KIGGPVYRIGVGGGAASSV++QGD+S D+ DLGAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GAII S F GDPT+++LELWGAEYQESN LL+ +++C RE+CP++ VG +TGDG I L++ +L VDL L VLGKMP+K+F ++ + L LP L V+DAL+RVLRLP+V SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+VALS F I G ATAIGEQPIK L+ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA+LW+AC A C ++ L IAIDGGKDSLSMAA V T VK+PG+LV+SAY CPDI VTPDL+ G G L+W+ ++ +RLGGSALAQ Y QLGD P+ D L +N Q + ++L SA HDISDGGLI CLLEMAFAGN GIDV + S + + +LF+EE G ++EV +++ TV + IG +C + V++ V+ + KL R +WEDTS+ LE+LQ N CV +E + S ++++S RVA++REEGSNGDREM+ + +GFE WD+TMQDL S +TLE+F ++FVGGFS+ DVLGSAKGWAA + YN K K +F F R+DT SLGVCNGCQL+ LGW+ + E ++L+HN+S RFESRF V I + + S+ L + G+ LGVWVAHGEG +F + + ++ +S GL L Y++ +V YP NPNGS +AGLCS+DGRHLA+MPHPER + WQW + D S + SPW+ +F +A W K
Sbjct: 1 MAVVRFYSNEAVQG---RALQRAAKLYPQLSITTELCYNVELTGCESLSEEQKEVLLWLFRPPLQAEPLSEKP-NLSAGSGERLVEIGPRLNFSTAWSTNAVSMCRSAGLTNVTRVELSRRFLIKPQHGESTQDVNGDVKKLIECLYDGMTECIYQHPITSFTVETKPQPVFEVDILGNGRAALEAANDELGLAFDSWDLDYYTSMFQRI-KRNPTSVECFDLAQSNSEHSRHWFFRGRMVIDKQEQKETLFSLIMDTQQHSNQNNVIKFCDNSSGIKGMELDCVYPKDPSQASPYETRRSLRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGRGGHVIAGTAGYCFGNLHIPGYVLPWEPEGEGWEYPSSFAPPLQVAIEASDGASDYGNKFGEPVLSGFARSFGMRLANGERREWIKPIMFSGGLGSIEDTHVKKEEAETGMEVVKIGGPVYRIGVGGGAASSVQVQGDNSNDR--DLGAVQRGDAEMEQKMNRALRACLERSGGNPICSIHDQGAGGNGNVLKELSEPAGAIIYCSRFKKGDPTLSVLELWGAEYQESNALLLQPADRSFLERVCQREKCPVDFVGNITGDGKIVLVDDEGGSRDLADRGRCPVDLQLDWVLGKMPQKEFRMERLTPTHQALTLPAGLTVKDALTRVLRLPAVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSPFSIEGVATAIGEQPIKGLVCPAAGARMAVGEALTNLVFARVTALKDVKCSGNWMWAAKLPGEGASLWEACKAMCEVMGQLGIAIDGGKDSLSMAARVGKET-VKAPGALVISAYAVCPDITATVTPDLEDPDGKGMLLWVPLSPGHHRLGGSALAQCYSQLGDCSPDLDKPYLLTSCFNTTQTLIHDRLLSAGHDISDGGLISCLLEMAFAGNRGIDV---------ELSQGTGVMELLFSEELGLVLEVSESHVKTVRQRYSDAGVECHHIGRTCG-FGPEAMVSVRVDGQEVLRE-KLPNLRALWEDTSFQLERLQANELCVQQEKEGLAKRTQPYFNLTFDPSETPSIDQLSSGQPRVAVVREEGSNGDREMSVSLYMAGFEVWDVTMQDLCSGSLTLEQFKAVVFVGGFSYADVLGSAKGWAATVTYNPKAKAEFDRFWQRDDTLSLGVCNGCQLLALLGWVGEGEDAAGSE----VVLTHNESGRFESRFVSVGI-EKSPSVWLRGMEGSALGVWVAHGEGLMQFRSSQAKNRIISGGLAPLRYLDDQGQPTEV--YPLNPNGSPQGIAGLCSRDGRHLAMMPHPERCTLGWQWPWAPRDFRASLKPSPWLRMFKNAAAWCSK 1315
BLAST of Phosphoribosylformylglycinamidine synthase vs. TrEMBL
Match: A0A087Y6E0 (Phosphoribosylformylglycinamidine synthase OS=Poecilia formosa OX=48698 PE=3 SV=2) HSP 1 Score: 1264.98 bits (3272), Expect = 0.000e+0 Identity = 684/1340 (51.04%), Postives = 888/1340 (66.27%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMS----IEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFS-SENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETD-PCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDL-----KGDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG-DLDVSTEVSPWMCIFNSAYEW 4078
M VL FY S + R L L + T+E+CYN+E+ G E + +L + R + ++P++ Q + S +EIGPRLNF T STNAV I +S G + ++R E S + ++ D + ++I+ +HD MTE Y H I SF + AP PVF +D++ +G ALE N +GLA D WDL YY +F I +RNP++VECFDLAQSNSEHSRHWFF+G+M+IDG E +LF ++ +TQ++SNQNNVI F DNSS I+G +Y DP+ S YE + S ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P Y+LPWE + ++YPS+FA ++ IEAS+GASDYGN+FGEPV++GF RSFGM +GE +EWIKPIMFSGG+G + +V K V+KIGGPVYRIGVGGGAASSV++QGD+ ++ DLGAVQRGDA+ME KMNR +R C++ + NPI SIHDQGAGGNGNVLKEL +P GA+I S F GDPT+++LELWGAEYQESN LL+ +++C RE+CP++ VG++TGDG I L++ + + + + VDL L VLGKMP+K+F ++ + L PL LP+ L V DAL RVLRLP+V SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+VALS F + GAATAIGEQP+K L+ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA LWDAC A C ++ L +AIDGGKDSLSMAA V T VK+PG+LV+SAY CPDI VTPDL K G L+W+ ++ ++RLGGSALAQ Y QLGD CP+ D + QK+ ++L SA HDISDGGL+ CLLEMAFAGN G DV ++ S+ S + +LF+EE G ++EV L V L IG +C + TV + V+ + S L + R +WE TS+ LE+LQ + CV +E + S ++ + + RVA++REEGSNGDREM+ + +GFE WD+TMQDL S +TL+ F ++FVGGFS+ DVLGSA+GWAA + YN K K +F+ F+ REDT SLGVCNGCQL+T LGW+ + E+ +++L+HN S RFESRF V I Q++ SI L + G+ LGVWVAHGEG F + S GL + Y LD YP NPNGS +AGLCS+DGRHLA+MPHPER + WQW + DL + SPW+ +F +A W
Sbjct: 1 MAVLRFY---SGEALIGRALQRAAKLFPHLSITTELCYNVELTGCERLDAAQTEVLLWLFRPP----LQAEPLSDQPRLTEGSGDKLVEIGPRLNFSTAWSTNAVSICQSAGLSNVTRVERSRRFLIKVADGDTGSADVKELIECLHDSMTECVYQHPITSFAVETAPQPVFEVDVLGKGCAALETANSELGLAFDSWDLDYYTSMFQRI-NRNPTSVECFDLAQSNSEHSRHWFFRGRMVIDGQEQPATLFSLIMDTQRHSNQNNVIKFCDNSSGIRGGELRCIYPADPSEASPYETRRSVRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGRGGHVIAGTAGYCFGNLHIPGYSLPWEQEGEGWEYPSSFAPPLQVAIEASDGASDYGNKFGEPVLSGFARSFGMRLANGERREWIKPIMFSGGLGSIEDNYVKKEEAEAGMEVVKIGGPVYRIGVGGGAASSVQVQGDNCSER--DLGAVQRGDAEMEQKMNRALRACLERSNGNPICSIHDQGAGGNGNVLKELSEPAGAVIYCSKFKKGDPTLSVLELWGAEYQESNALLLRPSDKSYLERVCQREKCPVDFVGRITGDGKIVLVDDEGSDGDRADGVRHPVDLQLDWVLGKMPQKEFRMERLAPTLLPLSLPVELTVRDALQRVLRLPAVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSPFGLQGAATAIGEQPVKGLVCPAAGARMAVGEALTNLLFARVTALKDVKCSGNWMWAAKLPGEGACLWDACKAMCEVMGQLGVAIDGGKDSLSMAARVGTET-VKAPGALVISAYAVCPDITATVTPDLEDPDGKALGVLLWVPVSPGRHRLGGSALAQCYSQLGDVCPDLDRPEFLSACFTTTQKLLEDRLLSAGHDISDGGLVSCLLEMAFAGNRGFDVELS--------SDGSGVMELLFSEELGLVLEVSQTDLEAVCQRYRDGGLRCHRIGRTCG-FGPEATVRVRVDGQEVLSE-SLPDLRAVWEATSFQLERLQADELCVKQEEEGLSRRMQPYFKLTFDPSETPSIRQLAAGLPRVAVVREEGSNGDREMSVSLFMAGFEVWDVTMQDLCSGSVTLQPFKAVVFVGGFSYADVLGSARGWAATVAYNPKAKAEFERFQRREDTLSLGVCNGCQLLTLLGWVGEGEEGAG-ELDSEVVLTHNRSGRFESRFVSVGI-QSSPSIWLRGMEGSALGVWVAHGEGLMRFRSPWAQDLITSSGLAPVRY--LDDQGSPTEEYPLNPNGSPQGIAGLCSRDGRHLAMMPHPERCTLGWQWPWAPRDLRPALSPSPWLRMFRNAAAW 1315
BLAST of Phosphoribosylformylglycinamidine synthase vs. TrEMBL
Match: B5DEE8 (Glutamine amidotransferase type-1 domain-containing protein OS=Xenopus tropicalis OX=8364 PE=2 SV=1) HSP 1 Score: 1264.6 bits (3271), Expect = 0.000e+0 Identity = 692/1350 (51.26%), Postives = 894/1350 (66.22%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITR----SDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPS----MPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGS---LIWIRM-NSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKE---YQFYGNP--NITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCE--MKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVEK 4087
M VLHFY+ + S++ R N+ E+CYN+ G Q L + +I+D SS + ++ +EIGPRLNF T STNAV I +S+G + R E S Y + S+ +++ +++D+MTE YP + SF ++V P V+ +DI+ +G ALE+ N +GLA D WDL YY +F + RNPS+VECFDLAQSNSEHSRHWFFKG++ +DG E E SLFD++ +TQ SN NNVI F DNSSAI+G L DP+ Y + S +++ FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G G +V+AGTAGYCFGNL +P Y+LPWE DP ++YP FA+ ++ IEASNGASDYGN+FGEPV+ GF RSFG+ SGE +EW+KPIMFSGGIG + +H K +P V+K+GGPVYRIGVGGGAASS+++QGD++ ELD GAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I +F LGDPT+++LE+WGAEYQESN LL+ + + +C RER P++ VGK+TGDG I LIN + D + +P VDL L VLGKMP+K+F L V L PL LP L V AL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+V+LSY DIVG ATAIGEQPIK L+N GA+L V EALTNL VT +D+K SGNWMW AKLPGEGA L+DAC A C ++ L +AIDGGKDSLSMAA V T VK+PGSLV+S Y CPDI VTPDLK G L+++ + Q+RLGGSALAQ Y QLG+ P+ D+ +N Q++ +++ SA HD+SDGGL+ C+LEMAFAGN G+D+ I++S + + +LF EE G ++EV + V+ + + IG + +R + V + N + N KLG R +WE+TS+ LE+LQ N CV++E + P ++T NP I L P + + RVA++REEGSNGDREMAA+ + +GF+ WD+TM+DLL+ TL+ F GL+FVGGFS+ DVLGSAKGWAA++K+N ++++F+NF+ R DTFSLGVCNGCQLM LGW+ + D + ++LSHN S RFESRF + I Q + SI+L + G+ LGVWVAHGEG F + + S+ L L YV D YP NPNGS +AGLCS DGRHLA+MPHPER M WQW + + S +VSPWM +F + Y W ++
Sbjct: 1 MVVLHFYRSLQNSSETLRLPGAENIQS----LQRELCYNVNWTGPAAPSSQETDALRWLFSCPFDPQSISDTSS----LHSEPSDLLVEIGPRLNFSTATSTNAVSICRSVGLTNVDRIECSKRYLIKFQTRPQGSEEQELLASLYDRMTECVYPEPVRSFEVSVRPEKVYEVDILGQGRAALEKANTELGLAFDSWDLDYYSSLFQRV-GRNPSSVECFDLAQSNSEHSRHWFFKGKLKVDGQEKEMSLFDMIMKTQDTSNPNNVIKFCDNSSAIQGREVASLIPTDPSCAGPYHLCRSTRHLIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSTGRGAHVIAGTAGYCFGNLHIPGYSLPWE-DPAYQYPVQFARPLEVAIEASNGASDYGNKFGEPVLAGFARSFGVRLPSGERREWVKPIMFSGGIGSMEDVHRTKEAPEPGMHVVKVGGPVYRIGVGGGAASSIQVQGDNA--SELDFGAVQRGDAEMEQKMNRAVRACVERGGKNPICSIHDQGAGGNGNVLKELSEPQGAVIYTKSFQLGDPTLSVLEIWGAEYQESNALLLRPDDAEFLRSVCRRERSPVDFVGKITGDGRIVLINGSDTDPAPDSTDRNAVP--VDLQLEWVLGKMPRKEFVLNRVAPNLQPLVLPSGLTVGQALDRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVSLSYSDIVGGATAIGEQPIKSLLNPAAGARLAVAEALTNLLFAQVTDLKDVKCSGNWMWAAKLPGEGALLYDACAAMCDVMAQLGVAIDGGKDSLSMAARVGTET-VKAPGSLVISVYAVCPDITTTVTPDLKNPGQKGVLLYLPLCPGQHRLGGSALAQCYSQLGETPPDLDDPQTLISCFNVTQQLLRDRVLSAGHDVSDGGLVTCILEMAFAGNCGLDIEISSSCTNV--------LELLFAEEPGLVLEVAEQSVELVMERYRAAGVECVRIGCTKERGPAS-MVRIRANGQEVV-NEKLGSLRAVWEETSFQLERLQANPSCVSQEEAGLRVREGPSYHLTFNPSEIP---LVPPS-VGGNQPRVAVVREEGSNGDREMAASLLMAGFQVWDVTMEDLLAGGTTLDSFRGLVFVGGFSYADVLGSAKGWAASVKFNASVREQFENFRRRADTFSLGVCNGCQLMALLGWVGPDNPTDTVGDLPTQGVLLSHNLSGRFESRFVTLKI-QQSPSILLRGMAGSTLGVWVAHGEGYMRFRSPKVQDYVTSNHLAPLCYV--DDGGKPTEEYPMNPNGSPLGIAGLCSADGRHLAMMPHPERCVMKWQWPWMPESWRQSLDVSPWMRLFQNGYRWCQE 1318
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Cavefish
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:103033258]) HSP 1 Score: 1214.13 bits (3140), Expect = 0.000e+0 Identity = 673/1342 (50.15%), Postives = 884/1342 (65.87%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRN-----DIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDL---KGDGSLIWIRMNS-QYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFV---ISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVE 4084
M VL FY+ ++ R L L T+E+CYN+E+K E + + +L + + + +P +EIGPRLNF T STNAV I +S G ++++R E+S H + N RN ++ ++D MTE Y I SF+++V P VF +DI+ +G ALE+ N +GLA D WDL YY +F + RNP++VECFDLAQSNSEHSRHWFF+G+M++DG E + +LF ++ TQ++SNQNNVI F DNSS IKG ++ DP+ S YE + + ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P ++LPWE D ++YPS FA ++ IEAS+GASDYGN+FGEPV+ GF RSFGM +GE +EWIKPIMFSGG+G + HV K V+KIGGPVYRIGVGGGAASSV++QGD+S D+ DLGAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I S F GDPT+++LELWGAEYQESN LL+ +K+C RE+CP++ VGK+TGDG I L++ + + + + VDL+L VLGKMP+K+F + V L PL LP L V AL RVLRLP+V SKR+LTNKVDRSV+GL+AQQQCVGPLHTPLADVA+VALS F + GAATAIGEQPIK L++ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA LW+AC A C ++ +L +A+DGGKDSLSMAA V T VK+PG+LV+S Y CPDI VTPDL +G G L+++ +++ +YRLGGSALAQ Y QLGD CP+ D+ L +N Q + + L SA HD+SDGGLI CLLEMAFAGN G++V + + LF+EE G ++EV N +V + L+ IG +C + V +++ + N L RT+WE TS+ LE+LQ N CV +E + + PF + +++ RVA++REEGSNGDREMA + +GFE WD+TMQDL S TL+ F ++FVGGFS+ DVLGSAKGWAA + +N + +++F+ F+ REDT SLGVCNGCQL+ LGW+ + + D+IL+HN S RFESRF V I + ++ML + G+ LGVWVAHGEG +F E + +S L + Y+ D + YP NPNGS +AG+CS DGRHLA+MPHPER+ + WQW + L S + SPW+ +F +A W +
Sbjct: 1 MTVLQFYR--REESEGGRTLRRVKQLYPYATITTELCYNVELKDAESLSKEQKDVLRWLFSPPHSVALLDEPTLKVTSPGETLVEIGPRLNFSTAWSTNAVSICQSAGLDLVTRVEVSR-RHLIKDGQN--GPRNGGEMEKLVALLYDSMTECVYTKPIASFSVDVQPQKVFEVDILGKGRAALEKANDELGLAFDSWDLDYYTALFQRV-KRNPTSVECFDLAQSNSEHSRHWFFRGRMVVDGQEQKDTLFSLIMGTQQHSNQNNVIKFCDNSSGIKGMELECMFPTDPSQASCYETRSTTRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGQGGHVIAGTAGYCFGNLHIPGFSLPWEED-GWEYPSTFAPPLQVAIEASDGASDYGNKFGEPVLAGFARSFGMRLANGERREWIKPIMFSGGLGSIEDKHVKKEEAEPGMEVVKIGGPVYRIGVGGGAASSVQVQGDNSSDR--DLGAVQRGDAEMEQKMNRALRACLERATGNPICSIHDQGAGGNGNVLKELSEPAGAVIYTSMFKRGDPTLSVLELWGAEYQESNALLLRPSDRGFVEKVCQREKCPVDFVGKITGDGKIVLVDDLNNQCDGVNNGRCPVDLELDWVLGKMPQKEFVMDCVVPSLKPLSLPAGLSVLPALERVLRLPAVASKRYLTNKVDRSVTGLIAQQQCVGPLHTPLADVAVVALSPFSLQGAATAIGEQPIKGLVSPAAGARMAVGEALTNLVFAQVTALKDVKCSGNWMWAAKLPGEGAYLWEACQAMCKVMGELGVAVDGGKDSLSMAARVGGET-VKAPGALVISVYAVCPDITATVTPDLDDQEGKGVLLYVPVSAGKYRLGGSALAQCYGQLGDCCPDLDHPDLLSACFNTTQLLIQDHLLSAGHDVSDGGLISCLLEMAFAGNRGLEVNL--------PFEGVGVMEALFSEELGLVLEVCENNADSVCQRYTNAGLVCHRIGTTCG-FGPDSMVRVSLCGQEVL-NESLPTLRTLWESTSFQLERLQANPLCVLQEEEGL---TTRTEPFFKLSFDPTEFPLLKELDGGKPRVAVVREEGSNGDREMAVSLFMAGFEVWDVTMQDLCSGSKTLDPFRAVVFVGGFSYADVLGSAKGWAATVTFNTRAREEFERFRRREDTLSLGVCNGCQLLALLGWVGGAD-----DGGSDVILTHNKSGRFESRFVSVGI-LPSPAVMLKGMEGSALGVWVAHGEGLMQFRCPEAQDRLISASLAPVRYI--DDSGAPTETYPMNPNGSAQGIAGICSPDGRHLAMMPHPERAVLGWQWPWVPQPLRASLKPSPWLRMFQNAAAWCQ 1311
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Cavefish
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:103033258]) HSP 1 Score: 1202.58 bits (3110), Expect = 0.000e+0 Identity = 678/1337 (50.71%), Postives = 881/1337 (65.89%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEIS--HIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDL---KGDGSLIWIRMNS-QYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVIS-DSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGD-LDVSTEVSPWMCIFNSAYEWVE 4084
M VL FY+ ++ R L L T+E+CYN+E+K I ++ S I F+ + S RLNF T STNAV I +S G ++++R E+S H+ N + K ++ ++D MTE Y I SF+++V P VF +DI+ +G ALE+ N +GLA D WDL YY +F + RNP++VECFDLAQSNSEHSRHWFF+G+M++DG E + +LF ++ TQ++SNQNNVI F DNSS IKG ++ DP+ S YE + + ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P ++LPWE D ++YPS FA ++ IEAS+GASDYGN+FGEPV+ GF RSFGM +GE +EWIKPIMFSGG+G + HV K V+KIGGPVYRIGVGGGAASSV++QGD+S D+ DLGAVQRGDA+ME KMNR +R C++ NPI SIHDQGAGGNGNVLKEL +P GA+I S F GDPT+++LELWGAEYQESN LL+ +K+C RE+CP++ VGK+TGDG I L++ + + + + VDL+L VLGKMP+K+F + V L PL LP L V AL RVLRLP+V SKR+LTNKVDRSV+GL+AQQQCVGPLHTPLADVA+VALS F + GAATAIGEQPIK L++ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA LW+AC A C ++ +L +A+DGGKDSLSMAA V T VK+PG+LV+S Y CPDI VTPDL +G G L+++ +++ +YRLGGSALAQ Y QLGD CP+ D+ L +N Q + + L SA HD+SDGGLI CLLEMAFAGN G++V + A LF+EE G ++EV N +V + L+ IG +C + V +++ + N L RT+WE TS+ LE+LQ N CV +E + G T F +S D P K K RVA++REEGSNGDREMA + +GFE WD+TMQDL S TL+ F ++FVGGFS+ DVLGSAKGWAA + +N + +++F+ F+ REDT SLGVCNGCQL+ LGW+ + D+ D+IL+HN S RFESRF V I + ++ML + G+ LGVWVAHGEG +F E + +S L + Y+ D + YP NPNGS +AG+CS DGRHLA+MPHPER+ + WQW + L S + SPW+ +F +A W +
Sbjct: 11 MTVLQFYR--REESEGGRTLRRVKQLYPYATITTELCYNVELKEKFFFFY--------------ILNLLSVQIQFKKLLFVFSF----RLNFSTAWSTNAVSICQSAGLDLVTRVEVSRRHLIKNGPRNGGEMEK---LVALLYDSMTECVYTKPIASFSVDVQPQKVFEVDILGKGRAALEKANDELGLAFDSWDLDYYTALFQRV-KRNPTSVECFDLAQSNSEHSRHWFFRGRMVVDGQEQKDTLFSLIMGTQQHSNQNNVIKFCDNSSGIKGMELECMFPTDPSQASCYETRSTTRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGQGGHVIAGTAGYCFGNLHIPGFSLPWEEDG-WEYPSTFAPPLQVAIEASDGASDYGNKFGEPVLAGFARSFGMRLANGERREWIKPIMFSGGLGSIEDKHVKKEEAEPGMEVVKIGGPVYRIGVGGGAASSVQVQGDNSSDR--DLGAVQRGDAEMEQKMNRALRACLERATGNPICSIHDQGAGGNGNVLKELSEPAGAVIYTSMFKRGDPTLSVLELWGAEYQESNALLLRPSDRGFVEKVCQREKCPVDFVGKITGDGKIVLVDDLNNQCDGVNNGRCPVDLELDWVLGKMPQKEFVMDCVVPSLKPLSLPAGLSVLPALERVLRLPAVASKRYLTNKVDRSVTGLIAQQQCVGPLHTPLADVAVVALSPFSLQGAATAIGEQPIKGLVSPAAGARMAVGEALTNLVFAQVTALKDVKCSGNWMWAAKLPGEGAYLWEACQAMCKVMGELGVAVDGGKDSLSMAARVGGET-VKAPGALVISVYAVCPDITATVTPDLDDQEGKGVLLYVPVSAGKYRLGGSALAQCYGQLGDCCPDLDHPDLLSACFNTTQLLIQDHLLSAGHDVSDGGLISCLLEMAFAGNRGLEVNLPFEGA-------------LFSEELGLVLEVCENNADSVCQRYTNAGLVCHRIGTTCG-FGPDSMVRVSLCGQEVL-NESLPTLRTLWESTSFQLERLQANPLCVLQEEE--GLTTRTEPFFKLSFDPTEFPLLKELGKP-RVAVVREEGSNGDREMAVSLFMAGFEVWDVTMQDLCSGSKTLDPFRAVVFVGGFSYADVLGSAKGWAATVTFNTRAREEFERFRRREDTLSLGVCNGCQLLALLGWVGGA---DDGGEGSDVILTHNKSGRFESRFVSVGI-LPSPAVMLKGMEGSALGVWVAHGEGLMQFRCPEAQDRLISASLAPVRYI--DDSGAPTETYPMNPNGSAQGIAGICSPDGRHLAMMPHPERAVLGWQWPWVPQPLRASLKPSPWLRMFQNAAAWCQ 1295
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002087.1 (pep scaffold:Pmarinus_7.0:GL485690:1046:10953:1 gene:ENSPMAG00000001895.1 transcript:ENSPMAT00000002087.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 231.491 bits (589), Expect = 2.975e-68 Identity = 119/275 (43.27%), Postives = 165/275 (60.00%), Query Frame = 2
Query: 197 SEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHN 1021
+E CYN+E G E + +R L + +S + + IE+GPRLNF T STNAV I S+G + + R E S + F R + +HD+ TE Y H + SF L+V PV+ +D++ EG ALE N+ +GLA+DEWDL YY +F + RNP++VECFD+AQSNSEHSRHW F+G++ +DG +E+SLFD++ TQ++SN NNVI FSDNSSAI+G L +P PS + + ++V FTAETHN
Sbjct: 39 TEFCYNVEWDGPEAPSAEERRKLLWLFHPMLGGPGASSQSCLNPEGNDCLIEVGPRLNFSTAWSTNAVSICHSIGLHHVKRIECSQRHLFKFPTHPATQARRVLASGLHDRTTECVYDHPLGSFALSVRTEPVYHVDVLGEGRAALERANRELGLALDEWDLDYYTRLFRERVGRNPTSVECFDIAQSNSEHSRHWLFRGRLTVDGQALEESLFDMIIGTQQHSNPNNVIKFSDNSSAIRGGEVRCLVPAEPGAPSPLQETLTTRHVIFTAETHN 313
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Yeast
Match: ADE6 (Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000003293]) HSP 1 Score: 615.535 bits (1586), Expect = 0.000e+0 Identity = 458/1304 (35.12%), Postives = 683/1304 (52.38%), Query Frame = 2
Query: 347 IEIGPRLNFCTPLSTNAVCILKSLGF-NMISRFE------ISHIYHFSSENDNLLSKRNDI-IKNIHDKMTEMAY---PHQINSFNLNVAPSPVFTIDIMNEGIKA-----LEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSF--GMITHSG--EWKEWIKPIMFSGGIGQLSSLHVNKSSP-NVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELV--DPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLP-LNLQ----VEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIV---GAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAF-CSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDL---KGDGSLIWIRMNSQYR---LGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEK--LASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLST---VINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPN-------ITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQN-FKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQ-----NTKSIMLSRLLGARLGVWVAHGEGKFEFT-NQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPER--SFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWV 4081
I + PR +P S+ A I G + + R E I + F LL NDI +K ++D+MT+ Y P S + P P+ + + + K L + N +GLA+D ++ Y FV M R+P++VE F AQ NSEH RH F IDG++ + +LF ++ T K + + + A+SDN++ + + + K+ + ETHN PT V+PFPGAATG+GG IRD A G G G +G+ +L +P PWE + P + A A I+IEA G++ + NEFG P ING+ R+ ++ H G E + + KPIM +GG G + K++P +I +GG IG+GGGAASSV G+ S D LD +VQRG+ +ME + +VI C+ L + NPI+SIHD GAGG N L ELV + LGA D +P ++ +E+W E QE L + + L F++IC RER P VVG T + + +E+ L + P +DL++ ++ GK PK E I L LP NL ++DA+ RVL LPSVGSK FL DRSV+GL+ + Q VGP P+ADV + S + + G A A+GE+P+ LI+ AKL V E+L N+ V S IK+S NWM PA GEG+ L++A A L L +AI GKDS+SM +D V +P SL ++A+ + TP L D L+ + ++++ LG SAL QVY Q+G+K P + + K L ++ +K + A HD SDGGL+ LLEMAFA G+++ I D + ++++ LFNEE G + ++ LS ++N+ + S++G + + + T N++ I++N + E W TSY ++KL+ N + +E+ + +T NP +D +K +++S+ +VAILRE+G NG EMA F ++GF + D+TM DLL L++F GL GGFS+GDVLG+ GWA ++ Y+E ++ +F F R+DTF+ G CNGCQ ++ L + + CE N S ++E+R +V I Q + +S+ L+ + G++L + VAHGEGK F+ + E + DGL + YV D + +PFNPNGS + +AG+ S +GR LA+MPHPER W G + PW+ +F SA WV
Sbjct: 101 IRVVPRSGTISPWSSKATNIAHVCGLQDKVQRIERGLALLIKTVPGFP-----LLENLNDISLKCVYDRMTQQLYLTEPPNTMSIFTHEEPKPLVHVPLTPKDTKQSPKDILSKANTELGLALDSGEMEYLIHAFVETMKRDPTDVELFMFAQVNSEHCRHKIFNADWTIDGIKQQFTLFQMIRNTHKLNPEYTISAYSDNAAVLDSENDAFFFAPNSTTKEWTSTKERIP-LLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKTKCGLSGFSVSDLLIPGNEQPWELN--IGKPYHIASALDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQGKEEIRGFHKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGAASSV-ASGEGSAD--LDFASVQRGNPEMERRCQQVIDACVALGNNNPIQSIHDVGAGGLSNALPELVHDNDLGAKFDIRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFEEICKRERAPFAVVGHATAE------QKLIVEDPLLKTTP--IDLEMPILFGKPPKMS-----RETITEALNLPEANLSEIPSLQDAIQRVLNLPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGEKPVNALISASASAKLSVAESLLNIFAADVKSLNHIKLSANWMSPASHQGEGSKLYEAVQALGLDLCPALGVAIPVGKDSMSMKMKWDDKEVT-APLSLNITAFAPVFNTSKTWTPLLNRNTDDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKEDIVLAYHDRSDGGLLITLLEMAFASRCGLEINI-------DGGDLESQLTNLFNEELGAVFQISAKNLSKFEKILNENGVAKEYISIVGKPSFQSQEIKIINSTTNDV-IYANSR-SELEQTWSKTSYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNP---ADD-MKIGLELSSQRPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRFHLDDFIGLAACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGCQFLSRLKDI-----IPGCENWPS--FERNVSEQYEARVCMVQISQEKDNSSEESVFLNGMAGSKLPIAVAHGEGKATFSKSAEQLEKFEKDGLCCIRYV--DNYGNVTERFPFNPNGSTNGIAGIKSPNGRVLAMMPHPERVCRLEANSWYPEGKYEEWGGYGPWIRLFRSARRWV 1357
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Nematostella
Match: EDO49597 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFF5]) HSP 1 Score: 1233.78 bits (3191), Expect = 0.000e+0 Identity = 684/1369 (49.96%), Postives = 916/1369 (66.91%), Query Frame = 2
Query: 101 EVLHFYQIVSFSNKLKRNLVDNNL------LDGTIIATSEICYNIEIK-GXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMS--------IEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDN------LLSKRND-IIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEI-KDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEE--LDPSMP-------YIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMNSQ-YRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEM---KRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG-DLDVSTEVSPWMCIFNSAYEWVEK 4087
+++ FYQ+ S K +V + L ++ T +AT EIC+N+ I+ G EL+ D+++ L WL ++S +++ + +F ++K IEIGPRLNF T STNAV I SLG + R E S Y ++ N L K ++ +HD+MT+ Y I +F ++ P P + +D+M G ALE++NK +GLA DEWDL YY +F + RNP++VECFDLAQSNSEHSRHWFF G++++DG E+++SL ++ +TQ SN NNVI FSDNSS+IKG+ P+L ++PA S + + +D+ +++ F+AETHNFPTGVAPFPGA TGTGGRIRD+QA G G +V+AGTAGYCFGNL++P Y LPWE DP YP+N A A ++ IEASNGASDYGN+FGEPV+ GF RSFGM +GE +EW+KPIMFSGG+G + + V K +P V+KIGGP YRIGVGGGAASS+++QGD+ ELD GAVQRGDA+ME K+NR IR C+++ NPI SIHDQGAGGNGNVLKE+ +P GA+I +F LGDPT++++ELWGAEYQESN LL+ + + I RE+ P++ VG +TGDG I L + + EE LD S+ Y VDL+L VVLGKMPKK F L HV +L PL LP L V +AL RVLRLPSV SKR+LTNKVDRSV+GL+AQQQCVGPLHTP+A VA+ ALS+F VG+ATA+GEQPIK L++ GA++ V EALTNL +T +D+K SGNWMW AKLPGEGAAL+D C A C ++ +L IA+DGGKDSLSMAA V +T VK+PG+LVVS Y CPD+ L VTPDLK G+G+L+++RM ++ +RLGGSALAQVY Q+GD P+ DN LF ++N Q++ +KL ++ HD+SDGGL+ LLEMAFAGN G+D N + +S A I +LF EE G ++EV + V N + N + +IG + E + + + V+ + + K+ R +WE+TS+ LE LQ N CV E + + + P ++ +VA++REEGSNGDREM A+F +GF+ WD+TM D+ +TL+ F G++FVGGFS+ DVLGSAKGWAA + N K +F+ F R+DTFSLG+CNGCQLM LGW+ + + + + + +HN S RFESRF V+I +++ ++ML L G+ LGVWVAHGEG+ +F E +S L + YV+ D + YP NPNGS +AGLCS DGRHLA+MPHPER + WQWA+ + S SPW+ +F +AYEW K
Sbjct: 4 KIIRFYQVPGLSTG-KHEVVLSKLRAAIPRVEITKLAT-EICFNVSIQDGCELEADKVEHLEWLFSKSFERENLT-RDTSFSVEKIEAEQPASRCVVIEIGPRLNFSTANSTNAVSICHSLGLKKVDRIEQSVRYLIQTKPRNEDDEKPLTDKEEQTLVSKLHDRMTQCRYTKPITTFEIDFHPEPCYDVDVMEGGRGALEKVNKDLGLAFDEWDLNYYTKLFKEKVGRNPTSVECFDLAQSNSEHSRHWFFCGRLVVDGQEIDKSLMRMVKDTQITSNDNNVIKFSDNSSSIKGYQVPLLIPDEPATASKFHLSEDTTRHIIFSAETHNFPTGVAPFPGATTGTGGRIRDVQAAGRGAHVIAGTAGYCFGNLQIPGYKLPWE-DPDLVYPNNMAPALEVAIEASNGASDYGNKFGEPVLAGFARSFGMRMPNGERREWVKPIMFSGGLGTIDAHSVTKLAPEKGMEVVKIGGPAYRIGVGGGAASSIQVQGDNI--SELDFGAVQRGDAEMEQKLNRAIRACLEMGKRNPICSIHDQGAGGNGNVLKEICEPAGAVIRVKDFILGDPTLSVMELWGAEYQESNALLVRAEDAAKLRTISSREKVPVSFVGTITGDGRIVLEDDNSSEENGMLDTSLAKRQKTTKYPVDLELDVVLGKMPKKVFTLDHVSPMLQPLSLPQGLTVAEALRRVLRLPSVASKRYLTNKVDRSVTGLIAQQQCVGPLHTPVAGVAVTALSHFHTVGSATAVGEQPIKCLVDPGCGARMTVGEALTNLVFAKITDLKDVKCSGNWMWAAKLPGEGAALYDTCKAMCGVMAELGIAVDGGKDSLSMAARVGSDT-VKAPGALVVSVYAACPDVCLTVTPDLKLPGGNGTLLYVRMGAEGWRLGGSALAQVYQQIGDVSPDMDNPQLFISAFNTTQELLSQKLITSGHDVSDGGLVTTLLEMAFAGNCGLDT--NIPVTSWTPQHSKA-IDVLFAEELGLVLEVKPENVEAVQNAYQRNGVCCLVIGKTAGLGEGS-GILIKVDGETVLED-KMVALRDLWEETSFQLELLQSNPSCVEIEKAGLKHRKAPEYNLTFEPTAVTPIEDRDN-CPKVAVIREEGSNGDREMVASFYMAGFQVWDVTMNDICRGDVTLDGFRGVVFVGGFSYADVLGSAKGWAAVCQINPTAKAQFEAFLARDDTFSLGICNGCQLMALLGWVGSEDTGETPKFASPSQGVCFTHNISERFESRFVTVTI-ESSPALMLQGLEGSSLGVWVAHGEGRAQFVRPEVLDNVVSKNLAPVRYVDDDG--NITTQYPLNPNGSPLGIAGLCSPDGRHLAMMPHPERCTLPWQWAWMPEEWRGSMSTSPWLRMFQNAYEWCVK 1356
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Medaka
Match: pfas (phosphoribosylformylglycinamidine synthase [Source:NCBI gene;Acc:101156076]) HSP 1 Score: 1228 bits (3176), Expect = 0.000e+0 Identity = 687/1337 (51.38%), Postives = 869/1337 (65.00%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDN----LLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWET-DPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLK---GDGSLIWIRMN-SQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTG-DLDVSTEVSPWMCIFNSAYEW 4078
M V+ FY S R L L + T+E+CYN+E+ G E + + +L + R + S+ N +EIGPRLNF T STNAV I +S G ++R E+S + +N L +I +HD MTE Y I SF + PVF +DI+ +G ALE+ N +GLA D WDL YY +F I RNP++VECFDLAQSNSEHSRHWFF+G+M+IDG E +++LF ++ +TQ++SN NNVI F DNSS IKG +Y DP+ S YE + S ++V FTAETHNFPTGVAPF GA TGTGGRIRD+Q+ G GG+V+AGTAGYCFGNL +P Y LPWE+ ++YPS+FA ++ IEAS+GASDYGN+FGEPV++GF RSFGM +GE +EWIKPIMFSGG+G + HV K + V+KIGGPVYRIGVGGGAASSV+IQGD+ ++ DLGAVQRGDA+ME KMNR +R C++ D NPI SIHDQGAGGNGNVLKEL +P GA+I +S F GDPT+++LELWGAEYQESN LL+ + +C RE+CP++ VG +TGDG I L++ + S+ + VDL L VLGKMP+K+F L+ V PL+LP L V DAL RVLRLPSV SKR+LTNKVDRSV+GLVAQQQCVGPLHTPLADVA+VALS F + GAATAIGEQPIK L+ GA++ V EALTNL VT+ +D+K SGNWMW AKLPGEGA LW+AC A C ++ +L +AIDGGKDSLSMAA V T VK+PG+LV+SAY CPDI VTPDL+ G G L+W+ ++ +RLGGSALAQ Y QL D P+ D+ L ++ Q + +++ SA HDISDGGLI CLLEMAFAGN GID+ ++ S S + +LF+EE G ++EV + V + IG +C + V + V+ + L E R WEDTS+ LE LQ N CV +E + S ++ RVA++REEGSNGDREM+A+ + FE WD+TMQDL +TLE F ++FVGGFS+ DVLGSAKGWAAA YN K K +F F+ REDT SLGVCNGCQL+ LGW+ ++ E ++L+HN S RFESRF V I Q + SI L + G+ LGVWVAHGEG +F + +S GL L Y LD YP NPNGS VAGLCS+DGRHLA+MPHPER + WQW + +L S SPW+ +F +A W
Sbjct: 1 MAVVRFY---SSEAPDGRALQRAAKLFPHLTLTTELCYNVELTGRESLSAEEKEVLLWLFRPPLQAEPLSENPNLIESSEEKLVEIGPRLNFSTAWSTNAVSICRSAGLTNVTRVEVSRRFLVKPKNGKGTGELSGDMKKLIDCLHDSMTECVYHRPITSFAVETKRQPVFEVDILAKGRAALEKANDDLGLAFDSWDLDYYTSMFQRI-QRNPTSVECFDLAQSNSEHSRHWFFRGRMLIDGQEQKETLFSLIMDTQRHSNPNNVIKFCDNSSGIKGVEIECVYPKDPSRASPYETRLSLRHVIFTAETHNFPTGVAPFSGATTGTGGRIRDVQSAGRGGHVIAGTAGYCFGNLHIPGYELPWESAGEEWEYPSSFAPPLQVAIEASDGASDYGNKFGEPVLSGFARSFGMRLPNGERREWIKPIMFSGGLGSIEDSHVKKEEASPGMEVVKIGGPVYRIGVGGGAASSVQIQGDNCSER--DLGAVQRGDAEMEQKMNRALRACLERSDGNPICSIHDQGAGGNGNVLKELSEPAGAVIYSSRFKKGDPTLSVLELWGAEYQESNALLLHPSDRSFLESVCQREKCPVDFVGNITGDGKIVLVDDEGGSNDQVDSVRHPVDLQLEWVLGKMPQKEFRLERVALACQPLRLPAGLSVRDALQRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSPFSLEGAATAIGEQPIKGLVCPAAGARMAVGEALTNLMFARVTALKDVKCSGNWMWAAKLPGEGAYLWEACKAMCKVMSELGVAIDGGKDSLSMAARVGKET-VKAPGALVISAYAVCPDISATVTPDLEDPDGKGVLLWVPLSPGNHRLGGSALAQCYGQLADCSPDLDHAELLTACFSTTQTLLQDRIVSAGHDISDGGLISCLLEMAFAGNRGIDIELS--------SQGSEVMELLFSEELGVVLEVSECDVEAVCQRYSDAGVQCHRIGRTCG-FGPKAEVRVCVDGQEVLKE-SLPELRAAWEDTSFQLECLQANELCVKQEEEGLAKRTQPYFQLNFDPSESPSVRRLAGGPPRVAVIREEGSNGDREMSASLYMADFEVWDVTMQDLCCGSLTLELFKAVVFVGGFSYADVLGSAKGWAAAATYNAKAKAEFDRFQQREDTLSLGVCNGCQLLALLGWVGETADGAGSE----VVLTHNRSGRFESRFVSVGI-QESPSIWLRGMEGSALGVWVAHGEGLMQFRSSMAQDLIISGGLAPLRY--LDEQGFPTEEYPLNPNGSPQGVAGLCSRDGRHLAMMPHPERCTLSWQWPWAPRELRPSLVPSPWLRMFKNAAAW 1313
BLAST of Phosphoribosylformylglycinamidine synthase vs. Planmine SMEST
Match: SMESG000028663.1 (SMESG000028663.1) HSP 1 Score: 2624.35 bits (6801), Expect = 0.000e+0 Identity = 1323/1331 (99.40%), Postives = 1328/1331 (99.77%), Query Frame = 2
Query: 98 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGXXXXXXXXXXXXXXITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMISRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMHRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDILTETQKYSNQNNVIAFSDNSSAIKGFTTPILYINDPAYPSVYEIKDSFQNVCFTAETHNXXXXXXXXXXXXXXXXXRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKXXXXXXXXXXXXXAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLSVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLVAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGSLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVIINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDNCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWVEKL 4090
MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGDELDEDQLQRLLWLITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMI+RFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIM RNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFD+LTETQKYSNQNNVIAFSDNSSAIKGFTTPILYI DPAYPSVYEIKDSFQNVCFTAETHNFPTGVAPFPGAATGTGGRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKIGGPVYRIGVGGGAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDL+VVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGL+AQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGSLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDV INASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLD+CEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWVEKL
Sbjct: 1 MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGDELDEDQLQRLLWLITRSDNINDISSKPINFQLKKYNMSIEIGPRLNFCTPLSTNAVCILKSLGFNMINRFEISHIYHFSSENDNLLSKRNDIIKNIHDKMTEMAYPHQINSFNLNVAPSPVFTIDIMNEGIKALEEINKSMGLAMDEWDLLYYHDIFVNIMQRNPSNVECFDLAQSNSEHSRHWFFKGQMIIDGVEMEQSLFDMLTETQKYSNQNNVIAFSDNSSAIKGFTTPILYITDPAYPSVYEIKDSFQNVCFTAETHNFPTGVAPFPGAATGTGGRIRDIQAVGMGGYVVAGTAGYCFGNLRLPYYTLPWETDPCFKYPSNFAQASKIVIEASNGASDYGNEFGEPVINGFCRSFGMITHSGEWKEWIKPIMFSGGIGQLSSLHVNKSSPNVNQLVIKIGGPVYRIGVGGGAASSVEIQGDSSRDKELDLGAVQRGDAQMENKMNRVIRGCIDLRDLNPIKSIHDQGAGGNGNVLKELVDPLGAIIDASNFTLGDPTINLLELWGAEYQESNGLLIDERHLDQFKKICDRERCPINVVGKVTGDGNIRLINSVALEEELDPSMPYIVDLDLNVVLGKMPKKKFYLKHVEKILSPLKLPLNLQVEDALSRVLRLPSVGSKRFLTNKVDRSVSGLIAQQQCVGPLHTPLADVAIVALSYFDIVGAATAIGEQPIKMLINVKEGAKLCVIEALTNLCMIPVTSFEDIKVSGNWMWPAKLPGEGAALWDACNAFCSLLKDLKIAIDGGKDSLSMAATVNDNTVVKSPGSLVVSAYVCCPDIRLAVTPDLKGDGSLIWIRMNSQYRLGGSALAQVYCQLGDKCPEFDNVGLFKKSWNCLQKIFMEKLASAAHDISDGGLIGCLLEMAFAGNVGIDVKINASIADCDASNSSAEISILFNEETGWIIEVPNNYLSTVINDLESNELLFSLIGHSCKRYEVTPTVTLTVNELNIFSNFKLGEFRTMWEDTSYHLEKLQCNTECVNKEYQFYGNPNITSNPFVISDSWLKPYNKINSKVFRVAILREEGSNGDREMAAAFIKSGFETWDITMQDLLSDLITLEEFNGLIFVGGFSFGDVLGSAKGWAAAIKYNEKIKKKFQNFKIREDTFSLGVCNGCQLMTWLGWLNDSHSLDDCEMKRDIILSHNDSNRFESRFSVVSIPQNTKSIMLSRLLGARLGVWVAHGEGKFEFTNQEFCSQALSDGLIALNYVNLDATNDDVVNYPFNPNGSISNVAGLCSKDGRHLAIMPHPERSFMWWQWAYTGDLDVSTEVSPWMCIFNSAYEWVEKL 1331 The following BLAST results are available for this feature:
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 4
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 3
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 3
BLAST of Phosphoribosylformylglycinamidine synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Phosphoribosylformylglycinamidine synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Phosphoribosylformylglycinamidine synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Phosphoribosylformylglycinamidine synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028144 ID=SMED30028144|Name=Phosphoribosylformylglycinamidine synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=4205bpback to top protein sequence of SMED30028144-orf-1 >SMED30028144-orf-1 ID=SMED30028144-orf-1|Name=SMED30028144-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1332bp MEVLHFYQIVSFSNKLKRNLVDNNLLDGTIIATSEICYNIEIKGDELDEDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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