Bicaudal D protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028061 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Bicaudal D protein vs. TrEMBL
Match: A0A183KCM9 (Uncharacterized protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS12769 PE=4 SV=1) HSP 1 Score: 147.517 bits (371), Expect = 6.524e-35 Identity = 115/353 (32.58%), Postives = 177/353 (50.14%), Query Frame = 1 Query: 313 AVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNLQ----------RKNDGVKEI------SLADDLS------MNNNGPRPXXXXXXXXXXXXEDGVE--MDEDSVMTNMAMSNTSPWDLMLGGQQDEDNSNQP----------EFLRDLKVEVFEVYAQLRTICADLSFRNGN---DGSKPG-NTPDELALLEMDFKLGSLRDTLGELRGLLTDL 1257 AVE DY+ Q++ LQ DI+ +R DL +KK + EKN I++++ N+ L LN A L ++ + + + SM EHV +E L+ EI LREEK LE ++ V++ERN LL L+ + Q + ++ ++ TI +Q+ ++ LQ+T L N ++ L ++D VK + SL +L+ N P L +D VE MD+D+ M ++ N D++ D+ N P F+ +L+ EV E+Y Q+ +C +L G SK G +TPDELA++EMDF+LGSLR L +LRGLL DL Sbjct: 39 AVESDYDAQVKELQTDIIAMRIDLKKEKKMCRQMEREKNTTISELMQQNQSLTCRLNTSSENEALLREEMSTLRLEFLKHKSSMQEHVQSIESLRQEITKLREEKHHLENQLNTVVEERNSLLQSLNDSYQEIRMMRHVNNEHIATINIQDAEITRLQETASILHNRLHKLSIQTGEQKSSSNEDDRVKPVDSQPHRSLMAELAEQKMIQAENYNCSPFTLED-------DDNVEFEMDDDTYMAYLSCFN---QDIISDSLVPSDSHNIPLESSNVNTKETFINELRSEVTEIYQQMNRMCVELCALTGTKQESCSKAGTHTPDELAMVEMDFRLGSLRSVLTDLRGLLKDL 381
BLAST of Bicaudal D protein vs. TrEMBL
Match: A0A183N2Q9 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS22584 PE=4 SV=1) HSP 1 Score: 144.821 bits (364), Expect = 1.849e-33 Identity = 118/353 (33.43%), Postives = 177/353 (50.14%), Query Frame = 1 Query: 313 AVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNL------QRKN----DGVKEI------SLADDLS------MNNNGPRPXXXXXXXXXXXXEDGVE--MDEDSVMTNMAMSNTSPWDLMLGGQQDEDNSNQP----------EFLRDLKVEVFEVYAQLRTICADLSFRNGN---DGSKPG-NTPDELALLEMDFKLGSLRDTLGELRGLLTDL 1257 AVE DY+ Q++ LQ DI+ +R DL +KK + EKN I++++ N+ L LN A L ++ + + + SM EHV +E L+ EI LREEK LE ++ V++ERN LL L+ + Q + ++ ++ TI +Q+ ++ LQ+T L N ++ L Q+ N D VK + SL +L+ N P L +D VE MD+D T MA + D++ D+ N P F+ +L+ EV E+Y Q+ +C +L G SK G +TPDELA++EMDF+LGSLR L +LRGLL DL Sbjct: 39 AVESDYDAQVKELQTDIIAMRIDLKKEKKMCRQMEREKNTTISELMQQNQSLTCRLNTSSENEALLREEMSTLRLEFLKHKSSMQEHVQSIESLRQEITKLREEKHHLENQLNTVVEERNSLLESLNDSYQEIRMMRHVNNEHVATINIQDAEITRLQETASILHNRLHKLSIQTGEQKSNSNEDDRVKPVDSQPHRSLMAELAEQKMIQAENYNCSPFTLED-------DDNVEFEMDDD---TYMAYLSCFDQDIISDSLVPSDSHNIPLESSNVNTKETFINELRSEVTEIYQQMNRMCVELCALTGTKQESCSKVGTHTPDELAMVEMDFRLGSLRSVLTDLRGLLKDL 381
BLAST of Bicaudal D protein vs. TrEMBL
Match: A0A094ZLG2 (Bicaudal D-related protein 1 OS=Schistosoma haematobium OX=6185 GN=MS3_03778 PE=4 SV=1) HSP 1 Score: 144.05 bits (362), Expect = 3.373e-33 Identity = 122/374 (32.62%), Postives = 193/374 (51.60%), Query Frame = 1 Query: 241 LIEEFQQKIYXXXXXXXXXXXXXXAVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNLQ----------RKNDGVKEI------SLADDLS------MNNNGPRPXXXXXXXXXXXXEDGVE--MDEDSVMTNMAM-------SNTSPWDLMLGGQQDEDNSNQPEFLRDLKVEVFEVYAQLRTICADLSFRNGN---DGSKPG-NTPDELALLEMDFKLGSLRDTLGELRGLLTDL 1257 ++E QKI+ +E E+ LK +LEAVE DY+ Q++ LQ DI+ +R DL +KK + EKN I++++ N+ L LN A L ++ + + + SM EHV +E L+ EI LREEK LE ++ V++ERN LL L+ + Q + ++ ++ TI +Q+ ++ LQ+T L N ++ L ++D VK + SL +L+ N P L +D VE MD+D+ M ++ + P+D + + + + F+ +L+ EV E+Y Q+ +C +L G SK G +TPDELA++EMDF+LGSLR L +LRGLL DL Sbjct: 33 VLESLLQKIHSLEEERRILKLRLEAVESDYDDQVKELQTDIIAMRIDLKKEKKMCRQMEREKNTTISELMQQNQSLTCRLNTSSENEALLREEMSTLRLEFLKHKSSMQEHVQSIESLRQEITKLREEKHHLENQLNTVVEERNSLLESLNDSYQEIRMMRHVNNEHVATINIQDAEITRLQETASILHNRLHKLSIQTGEQKSSSNEDDRVKPVDSQPHRSLMAELAEQKMIQAENYNCSPFTLED-------DDNVEFEMDDDTYMAYLSCFDQDIISDSLVPFDSHNISLESSNVNTKETFINELRSEVTEIYQQMNRMCVELCALTGTKQESCSKVGTHTPDELAMVEMDFRLGSLRSVLTDLRGLLKDL 399
BLAST of Bicaudal D protein vs. TrEMBL
Match: A0A430QF30 (Coiled-coil domain-containing protein 64 OS=Schistosoma bovis OX=6184 GN=DC041_0001046 PE=4 SV=1) HSP 1 Score: 144.05 bits (362), Expect = 3.459e-33 Identity = 122/370 (32.97%), Postives = 188/370 (50.81%), Query Frame = 1 Query: 241 LIEEFQQKIYXXXXXXXXXXXXXXAVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNLQRKNDGVKEISLADD-LSMNNNGPRPXXXXXXXXXXXXE--------------DGVE--MDEDSVMTNMAMSNTSPWDLMLGGQQDEDNSNQP----------EFLRDLKVEVFEVYAQLRTICADLSFRNGN---DGSKPG-NTPDELALLEMDFKLGSLRDTLGELRGLLTDL 1257 ++E QKI+ +E E+ LK +LEAVE DY+ Q++ LQ DI+ +R DL +KK + EKN I++++ N+ L LN A L ++ + + + SM EHV +E L+ EI LREEK LE ++ V++ERN LL L+ + Q + + ++ TI +Q+ ++ LQ+T L N ++ L + K S DD + ++ P + + + D VE MD+D T MA + D++ D+ N P F+ +L+ EV E+Y Q+ +C +L G SK G +TPDELA++EMDF+LGSLR L +LRGLL DL Sbjct: 33 VLESLLQKIHSLEKERRILKLRLEAVESDYDAQVKELQTDIIAMRIDLKKEKKMCRQMEREKNTTISELMQQNQSLTCRLNTSSENEALLREEMSTLRLEFLKHKSSMQEHVQSIESLRQEITKLREEKHHLENQLNTVVEERNSLLQSLNDSYQEIRMMRHANNEHIATINIQDAEITRLQETASILHNRLHKLSIQTGEQKSSSNEDDRVKTVDSQPHRSLMAELAEQKMIQAENYNCSPFTLEDDDNVEFEMDDD---TYMAYLSCFDQDIISDSLVPSDSHNIPLESSNVNTKETFINELRSEVTEIYQQMNRMCVELCALTGTKQESCSKVGTHTPDELAMVEMDFRLGSLRSVLTDLRGLLKDL 399
BLAST of Bicaudal D protein vs. TrEMBL
Match: A0A0R3WB84 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS7880 PE=4 SV=1) HSP 1 Score: 142.895 bits (359), Expect = 4.433e-33 Identity = 115/391 (29.41%), Postives = 201/391 (51.41%), Query Frame = 1 Query: 220 LKVKNELLIEEFQQKIYXXXXXXXXXXXXXXAVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQ------NSINNLQRK---NDGVKEIS---------LADDLSMNNN-------GPRPXXXXXXXXXXXXEDGVEMDEDSVMTNMAMSNTS-PWDLMLGGQQ------------DEDNSNQPEFLRDLKVEVFEVYAQLRTICADLSFRNGNDGS-----KPGN-TPDELALLEMDFKLGSLRDTLGELRGLLTDLM 1260 L+ +N+ L+E+F Q+I++++ EK +++ +L AVE DY+ Q++ LQ +I+ LR+++ QK+ E + + HN L L+ + ++ E Q+ ++ R ++ HV Q+E L++EI L+E+K LE ++Q ++ ER+ LL L AQQ L++ + I Q+ ++ LQ+ L+ NS+ + RK + G +++S L +LS N + L ++ +DG+E+D+ S++ M + T P G + S + EFL D + EV E+Y QLR +C D+S ++ + S +PG+ TPD+LA +E D +L SLR+ L +LRGLL DL+ Sbjct: 34 LRQENQQLLEQFCQQIHDIQREKETVRLRLIAVESDYDAQMKELQAEIMNLREEVQQQKRRSVQRTREHEATVQSLCEHNAALQKKLDEANQSATEASVQMKEMQQHLHTARAAIQSHVQQIESLRAEINHLKEDKATLEQKLQAIIDERDYLLTTLSDAQQANALLQQESANQQLVITCQDNELAQLQEAAALLKDQLQTLNSVASPSRKATVSTGAEKVSGQTSTPHQSLMGELSAANANNAEDDWWYKHVQLDPSMMEFYEDDGIEIDDASLLAAMTSNGTVLPNSEESGAAKMVTSSDLKCDDPSAGGSTEEEFLGDFRAEVAEIYQQLRQMCVDVSAQSSTNASSTTDHRPGDWTPDQLARIEWDCRLTSLRNVLTDLRGLLQDLV 424
BLAST of Bicaudal D protein vs. Planmine SMEST
Match: SMESG000060877.1 (SMESG000060877.1) HSP 1 Score: 844.343 bits (2180), Expect = 0.000e+0 Identity = 430/430 (100.00%), Postives = 430/430 (100.00%), Query Frame = 1 Query: 313 AVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNLQRKNDGVKEISLADDLSMNNNGPRPXXXXXXXXXXXXEDGVEMDEDSVMTNMAMSNTSPWDLMLGGQQDEDNSNQPEFLRDLKVEVFEVYAQLRTICADLSFRNGNDGSKPGNTPDELALLEMDFKLGSLRDTLGELRGLLTDLMKPHAVCNEDVSMQSMILKMEETSKVLDHKSKYLDQLQEELGFQERKLEELLRNMDSSEDTDKIKQMVLYKKYDIEQRMTRTRSEMEVLTSSMYLSETGDNQKFLDFEEDYCEYD 1602 AVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNLQRKNDGVKEISLADDLSMNNNGPRPANLWWNVWVANNEDGVEMDEDSVMTNMAMSNTSPWDLMLGGQQDEDNSNQPEFLRDLKVEVFEVYAQLRTICADLSFRNGNDGSKPGNTPDELALLEMDFKLGSLRDTLGELRGLLTDLMKPHAVCNEDVSMQSMILKMEETSKVLDHKSKYLDQLQEELGFQERKLEELLRNMDSSEDTDKIKQMVLYKKYDIEQRMTRTRSEMEVLTSSMYLSETGDNQKFLDFEEDYCEYD Sbjct: 14 AVECDYEMQLQALQKDIVTLRKDLSNQKKSQAFLVNEKNHEINDVINHNEKLMASLNIVKNENAGLNNKLMEFQEKVNNDRISMHEHVFQLELLKSEILSLREEKKQLEARIQEVMQERNILLVQLDQAQQRTEQLEKIDKQNRETIAVQEQDVLHLQQTTEFLQNSINNLQRKNDGVKEISLADDLSMNNNGPRPANLWWNVWVANNEDGVEMDEDSVMTNMAMSNTSPWDLMLGGQQDEDNSNQPEFLRDLKVEVFEVYAQLRTICADLSFRNGNDGSKPGNTPDELALLEMDFKLGSLRDTLGELRGLLTDLMKPHAVCNEDVSMQSMILKMEETSKVLDHKSKYLDQLQEELGFQERKLEELLRNMDSSEDTDKIKQMVLYKKYDIEQRMTRTRSEMEVLTSSMYLSETGDNQKFLDFEEDYCEYD 443 The following BLAST results are available for this feature:
BLAST of Bicaudal D protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Bicaudal D protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Bicaudal D protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Bicaudal D protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Bicaudal D protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Bicaudal D protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028061 ID=SMED30028061|Name=Bicaudal D protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1803bpback to top protein sequence of SMED30028061-orf-1 >SMED30028061-orf-1 ID=SMED30028061-orf-1|Name=SMED30028061-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=527bp MSQTTVSHSNLNIEISNCLKNYIERETTYNCNPSEKTIYDELEEKERDLLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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