FMRFamide-activated amiloride-sensitive sodium channel

Overview
NameFMRFamide-activated amiloride-sensitive sodium channel
Smed IDSMED30028029
Length (bp)2269
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of FMRFamide-activated amiloride-sensitive sodium channel (SMED30028029) t-SNE clustered cells

Violin plots show distribution of expression levels for FMRFamide-activated amiloride-sensitive sodium channel (SMED30028029) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FMRFamide-activated amiloride-sensitive sodium channel (SMED30028029) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FMRFamide-activated amiloride-sensitive sodium channel (SMED30028029) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30028029

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30028029h1SMcG0016111 dd_Smed_v4_13880_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30028029h1SMcG0016111 dd_Smed_v4_13880_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30028029h1SMcG0016111 dd_Smed_v4_13880_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30028029h1SMcG0016111 dd_Smed_v4_13880_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
anterior sideSMED30028029h1SMcG0016111 dd_Smed_v4_13880_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1G (sodium channel epithelial 1 gamma subunit [Source:HGNC Symbol;Acc:HGNC:10602])

HSP 1 Score: 51.6026 bits (122), Expect = 4.851e-6
Identity = 65/342 (19.01%), Postives = 127/342 (37.13%), Query Frame = 3 
Query:  735 HAQFINCFSYN-------IKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGN-ETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSL--KRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPT---KSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELL 1721
            H    NC+++N       +          +++ LY+NEE       + F+ +     +GA ++IH+ + +P +      ++   +T + +    +   + PY +C  +  S++ + N    +Y+  +C     Q ++  KC C     P           LP    +  C    H      C+ ++  +   + L C+S             C   C +  +    S++ WP+   + W L  L   +G  V  K                        LNK D     L  ++I   + N   + E    S+   LS  GG   +W+  +++ ++EIIE+ 
Sbjct:  277 HPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEE-----YNPFLVSS----TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDG-SDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQP-----------LPPAANY--CNYQQHPNWM-YCYYQLHRAFVQEELGCQS------------VCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKK------------------------LNKTD-----LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVF 553
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: asic-2 (Degenerin-like protein asic-2 [Source:UniProtKB/Swiss-Prot;Acc:Q22851])

HSP 1 Score: 61.2326 bits (147), Expect = 1.887e-9
Identity = 66/295 (22.37%), Postives = 111/295 (37.63%), Query Frame = 3 
Query:  201 HFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNI----SSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLG--------HDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVT--TIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTP 1043
             F   +T+  VP + N  NK S+I WI+ F+F+       L  LI +F  Y       +L      FP  TVCN  P  Y++    S+F +   +      A    + + K+       G Y+    ++ L        +   N++         + Y D + DC  +F        D  + I          +  C+S+N  A     V+   I+  L L      ++      S   ++L+GA + ++   S P ++   I+   G  + V +    NV    PYG C    P
Sbjct:   12 DFSNWSTVAVVPHVANANNKISRIFWIAIFLFVLGMFAYELYILIAKFFSYPATVNTEILFEK-QIFPVVTVCNMNPYKYSVVKSNSAFSSVNTLMTTYSDATVGTFSTDKW-------GLYADNDETYDLDSRAADALVLEANLISDTAKVPALYTYADLIQDC--SFAGIPCSESDFTKFI-------DPVYGACYSFNEDASLNYSVSREGIQFGLKLMLTVTQTKTNGNTDSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKKPYGTCVDREP 289
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: mec-4 (Degenerin mec-4 [Source:UniProtKB/Swiss-Prot;Acc:P24612])

HSP 1 Score: 58.151 bits (139), Expect = 2.154e-8
Identity = 59/286 (20.63%), Postives = 91/286 (31.82%), Query Frame = 3 
Query:  876 SQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRIS 1733
            ++ +G  L IH    FP  +    +   G ++   L+        APYG C P+  ++ +     Y Y+   C     Q  +  +C C    +PV   N   C A               D    KC +     L  L          H      C  PC    Y    S + WP+ S Q+  L S  G+ V   K  K      E F E                              N   + E E     + L+  GG   +W G++ ++  E + L +  +
Sbjct:  511 TEATGVRLTIHDKEDFPFPDTFGYSAPTGYVSSFGLRLRKMSRLPAPYGDCVPDGKTS-DYIYSNYEYSVEGCYRSCFQQLVLKECRCGDPRFPVP-ENARHCDAA--------------DPIARKCLDARMNDLGGL----------HGSFRCRCQQPCRQSIYSVTYSPAKWPSLSLQIQ-LGSCNGTAVECNKHYKENGAMVEVFYE----------------------------QLNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFLETA 741
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: mec-4 (Degenerin mec-4 [Source:UniProtKB/Swiss-Prot;Acc:P24612])

HSP 1 Score: 58.151 bits (139), Expect = 2.154e-8
Identity = 59/286 (20.63%), Postives = 91/286 (31.82%), Query Frame = 3 
Query:  876 SQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRIS 1733
            ++ +G  L IH    FP  +    +   G ++   L+        APYG C P+  ++ +     Y Y+   C     Q  +  +C C    +PV   N   C A               D    KC +     L  L          H      C  PC    Y    S + WP+ S Q+  L S  G+ V   K  K      E F E                              N   + E E     + L+  GG   +W G++ ++  E + L +  +
Sbjct:  511 TEATGVRLTIHDKEDFPFPDTFGYSAPTGYVSSFGLRLRKMSRLPAPYGDCVPDGKTS-DYIYSNYEYSVEGCYRSCFQQLVLKECRCGDPRFPVP-ENARHCDAA--------------DPIARKCLDARMNDLGGL----------HGSFRCRCQQPCRQSIYSVTYSPAKWPSLSLQIQ-LGSCNGTAVECNKHYKENGAMVEVFYE----------------------------QLNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFLETA 741
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: delm-1 (DEgenerin Linked to Mechanosensation [Source:UniProtKB/TrEMBL;Acc:O45402])

HSP 1 Score: 57.3806 bits (137), Expect = 3.181e-8
Identity = 109/537 (20.30%), Postives = 199/537 (37.06%), Query Frame = 3 
Query:  183 LKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNS------PSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDC--LITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVT--------TIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTF-FNVMKTAPYGRCKPNTPSNLEMGNETYSYTE----HLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRI 1730
            +K E  HFC+ TT+ G  RI       +K+ W+   +    GL I   +++      S +  P V Q S         FPS TVCN  P+  +     N+    +P       N+ ++  +   G+    SL   +  L  Y    P   +  +   + D   DC  L+   +      D C ++    +TP  +   CF+ ++    + + T        ++ L   L+E+ + S  ID  + N  S ++G    +H  ++ PN+  +   + P ++    +  F + ++    +G C  + P  ++      SYT      LCK K       N+C C    Y + N N   C+    +    +C  NS     E   E  K   +   C               C   C+   Y +D                 +S G+   +         A  YF       ++      D ++S    + I   + +     + +  S+T  LS +GG   +++G ++I+IVE+     ++
Sbjct:   66 VKRETQHFCETTTMHGPKRIFKGKRIFTKLFWL-IMVLGSLGLLIYQCWILSA----SYLSKPIVSQVSFLIPEDGMEFPSVTVCNFTPIRKSYIEAMNRTGDVSPDMINYLMNWFTEIPIL-LGNTDQQSLNKGNEELREYQSIHP---NFTVDQFFMDASFDCSDLMKLCSFQGESFDCC-SLASPTLTPVGK---CFTLDLSKSPMNKQTEPGIRAGLSLTLDANLDEQFDSSTGIDALLPN--SFVNGFRYFVHPKDTIPNLASDEYTVSPNSVAYSAISKFRYVLLPPNDWGNCTEDYPYGIQ---SNLSYTSGNCLSLCKAKYFM----NQCGCTPALYNIGN-NFQECTPFETY----NCVNNSLSLLNE---ETGKMEFQPPSCTR-------------CGQQCDSQVYRAD-----------------NSNGNQFSAG--------AFNYFNSKNSSWSV------DYMKSNFQMIRIFYRDMSYTEYNQVQDASITDLLSAIGGNMGMFLGGSVITIVELFLFFSKV 528
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: del-4 (DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P91835])

HSP 1 Score: 54.6842 bits (130), Expect = 1.747e-7
Identity = 100/524 (19.08%), Postives = 196/524 (37.40%), Query Frame = 3 
Query:  276 WISFFIFLCAGLTICLTF-----LIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRP--------LSYNISSFFNQRNM-RNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNM---LGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEF----IEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCC--KSRRLSL 1778
            W+  F  L   ++I L       L+  ++ +SV +    LQ +   FP+ T+C+  P        +  ++S+  +  N   +  +F + A+  + +    +     ++L+        Y E +  + +N    + + Y D V+ C         ++   C NI  +    +  + NC  +N    +       +  + + +  +++T +            ++ SG ++ IH  +  P  +       PGT + + +        + PYG C   T + L+  + T +YT   C    +Q +I   C C    Y   +             ++ SC+          C + I ++       +   VL   D    C  PCE  SY    S + WP+ S+  T  N    S         P+  + E              +  D  ++  I + I     N   + E    +  +F+S +GG   +++G+++IS +E + L+      V   CC  KSRR  +
Sbjct:   34 WLRAFWILVVVVSIALFIWQFITLLTNYLSFSV-NTETTLQFAERTFPTVTICHLNPWKLSETKSVDPDMSALIDAYNSDSSSAQFGLPASLTADR----QQQASKWTLM--------YSERLNEKQYNDAADIAYSYDDMVVSC--------TYNAKTC-NITDFNDFYNPSYGNCLQFNTDGMYSSSRAGPLYGLRMVMRTDQDTYLPW----------TEASGVIIDIHMQDEIPYPDVFGYFAPPGTASSLGVSYVQTTRLSKPYGSCT--TKTKLKTTHYTGTYTVEACFRSCMQEKIIASCGCYYPAYSHASNT----------TQYVSCDNGVQTLSNLNCVDLINSADS-----TEFDVLTDCD----CPQPCEIDSYGVTVSTAQWPSDSYVPTECNPGGPSG--------PWDASGE--------------SCLDWYKANTILIEIYYERMNFQVLTESPAYTFVNFISDVGGQVGLFLGMSIISAIEYLVLIFL----VFFYCCTHKSRRAEI 478
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891])

HSP 1 Score: 57.7658 bits (138), Expect = 5.802e-8
Identity = 83/399 (20.80%), Postives = 150/399 (37.59%), Query Frame = 3 
Query:  573 FSLSGYLESIPLEYHNMLGHDYYDFVIDCLI-----TFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIE------LYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNE----TYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 1724
              LS    ++PL     +G    D ++ CL      ++RN ++ +               A + NC+ +N   E  + + +        L L L+ E         ++  V++  + A L++H+  SFP +    I   PGT T + +         APY  C  N  S++ + N       SY+   C     Q ++   C C   +YP+ N +  +CS             N    +   C+  ++ S+   E             I  C  PC    Y+   S++ WP+   Q  W+      +V S ++   + I                +N+  I     + + I     N   + E E  ++   LS LGG F  W+G +++ I+E  E+++
Sbjct:  239 LQLSSIFSNVPLADRIAMGFKAEDLILTCLFGGQPCSYRNFTRIY--------------DADYGNCYIFNWGQEGEDPMASANPGADFGLKLVLDIEQGE------YLPYVQTT-AAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNG-SDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGS-EYCS-------------NDKYPDWVPCYYGLRDSVADRE-----------SCISLCQQPCNDTQYKMVISMADWPSAGAQ-DWI-----FHVLSYEKDSSHNIT---------------VNRNGI-----VRLNIYFQEFNYRSITESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIII 564
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891])

HSP 1 Score: 54.299 bits (129), Expect = 6.018e-7
Identity = 60/284 (21.13%), Postives = 98/284 (34.51%), Query Frame = 3 
Query:  885 SGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNE----TYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 1724
            + A L++H+  SFP +    I   PGT T + +         APY  C  N  S++ + N       SY+   C     Q ++   C C   +YP+ N +  +CS             N    +   C+  ++ S+   E             I  C  PC    Y+   S++ WP+                                       A EI +K D                N   + E E  ++   LS LGG F  W+G +++ I+E  E+++
Sbjct:  302 AAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNG-SDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGS-EYCS-------------NDKYPDWVPCYYGLRDSVADRE-----------SCISLCQQPCNDTQYKMVISMADWPSAG-------------------------------------AQEIWDKHDF---------------NYRSITESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIII 507
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic5 (acid-sensing (proton-gated) ion channel family member 5 [Source:MGI Symbol;Acc:MGI:1929259])

HSP 1 Score: 58.9214 bits (141), Expect = 1.531e-8
Identity = 109/529 (20.60%), Postives = 189/529 (35.73%), Query Frame = 3 
Query:  156 LNSPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHA--QFINCFSYNI------KAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNK-QDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIE 1715
            L SPT +K    +   F  +T+  G+  I    NK  K++W++  +   + L   +   +  +  +       V       FP+ T+CN            N+        F I        +L+D   K    L   S + +G  E++     N       +FV +      N +  H +        K   H   ++ NCF++N       K +       ++L L +++E      +  F        +G + VIH     P  +   ++   G    V ++    V +  P+G C PN      +   TY   +  CK + IQ                       C  LP  +     E +    E   C   I   L  +E K   T+  HN    +C + CE   Y +  S ST+P          S R +   +KK                       LN+ Q+ +   L+ + IN  + N    ++++ +S+   L+ +GG   ++ G +LI+I+EIIE
Sbjct:   28 LPSPTDRKKFDQD---FAMSTSFHGIHNIAQNQNKVRKVIWLAVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCN-----------LNRFQTEAVSRFGIIF------FLWDIVSKV-LRLQEISANNTGSPETLDF-VTNHQNFSITEFVKNNGFYLNNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFAD------AGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNFITYSTYGCLKE-CKARHIQ---------------------RLCGCLPFLLPGNGVECDL--LEYYNCVSPI---LDHIERKGLCTMGTHNS---SCPVSCEETEYPATVSYSTFP----------SQRATRFLAKK-----------------------LNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIE 465
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic5 (acid-sensing (proton-gated) ion channel family member 5 [Source:MGI Symbol;Acc:MGI:1929259])

HSP 1 Score: 57.3806 bits (137), Expect = 4.032e-8
Identity = 63/278 (22.66%), Postives = 104/278 (37.41%), Query Frame = 3 
Query:  885 SGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNK-QDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIE 1715
            +G + VIH     P  +   ++   G    V ++    V +  P+G C PN      +   TY   +  CK + IQ                       C  LP  +     E +    E   C   I   L  +E K   T+  HN    +C + CE   Y +  S ST+P          S R +   +KK                       LN+ Q+ +   L+ + IN  + N    ++++ +S+   L+ +GG   ++ G +LI+I+EIIE
Sbjct:  209 AGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNFITYSTYGCLKE-CKARHIQ---------------------RLCGCLPFLLPGNGVECDL--LEYYNCVSPI---LDHIERKGLCTMGTHNS---SCPVSCEETEYPATVSYSTFP----------SQRATRFLAKK-----------------------LNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIE 423
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 56.6102 bits (135), Expect = 1.097e-7
Identity = 71/341 (20.82%), Postives = 128/341 (37.54%), Query Frame = 3 
Query:  735 HAQFINCFSYNIKAE---FIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYS-YTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKT--SLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWP---TKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRI 1730
            H  + NC+++N K     ++  +  +   L L   T  +  I        S ++GA +++H  +    ++    N++PG  T + ++          YG C  N  S++ + N   S YT+ +C     Q  +  KC C  I YP   + + FC  L                    C+ +++   SL  L C S             C  PC   +Y+     S WP   ++ W    L+      + +K+                       + K +I   +L          N     E   +++ S LS LG  +S+W G +++S+VE+ EL+  +
Sbjct:  220 HPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLL-----STVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENG-SDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKP-KGVEFCDYL-------------KQSSWGYCYYKLQAAFSLDSLGCFSK------------CRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKR---------------------NGVAKLNIFFKEL----------NYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDL 497
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 56.225 bits (134), Expect = 1.143e-7
Identity = 71/341 (20.82%), Postives = 128/341 (37.54%), Query Frame = 3 
Query:  735 HAQFINCFSYNIKAE---FIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYS-YTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKT--SLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWP---TKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRI 1730
            H  + NC+++N K     ++  +  +   L L   T  +  I        S ++GA +++H  +    ++    N++PG  T + ++          YG C  N  S++ + N   S YT+ +C     Q  +  KC C  I YP   + + FC  L                    C+ +++   SL  L C S             C  PC   +Y+     S WP   ++ W    L+      + +K+                       + K +I   +L          N     E   +++ S LS LG  +S+W G +++S+VE+ EL+  +
Sbjct:  220 HPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLL-----STVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENG-SDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKP-KGVEFCDYL-------------KQSSWGYCYYKLQAAFSLDSLGCFSK------------CRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKR---------------------NGVAKLNIFFKEL----------NYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDL 497
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 55.8398 bits (133), Expect = 1.713e-7
Identity = 71/341 (20.82%), Postives = 128/341 (37.54%), Query Frame = 3 
Query:  735 HAQFINCFSYNIKAE---FIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYS-YTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKT--SLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWP---TKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRI 1730
            H  + NC+++N K     ++  +  +   L L   T  +  I        S ++GA +++H  +    ++    N++PG  T + ++          YG C  N  S++ + N   S YT+ +C     Q  +  KC C  I YP   + + FC  L                    C+ +++   SL  L C S             C  PC   +Y+     S WP   ++ W    L+      + +K+                       + K +I   +L          N     E   +++ S LS LG  +S+W G +++S+VE+ EL+  +
Sbjct:  301 HPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLL-----STVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENG-SDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKP-KGVEFCDYL-------------KQSSWGYCYYKLQAAFSLDSLGCFSK------------CRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKR---------------------NGVAKLNIFFKEL----------NYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDL 578
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1)

HSP 1 Score: 115.161 bits (287), Expect = 3.265e-25
Identity = 126/559 (22.54%), Postives = 233/559 (41.68%), Query Frame = 3 
Query:  216 TTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNI--SSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNM------LGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIE--LYLYLNEETNVSRCIDCFISNVKSQL---SGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYP-VVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHND----IIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKE---------GREDKAI-EILNKQDILESKLIA-----------VVINRPNKNLHRVEEKEV--LSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRI------SEKVLDR 1751
            +   G+ +IV + +   K++W    I      T+ L+ L+R+++++ V+    +  + P  +PS ++CN  P+S       +FN     N  +  I      +K+ F++                 ++ SI   Y N+      L H+  D ++ C        + + +LC ++  +       + NCF++N         T  E  L L  + E +        + N  + +   +G  +V+H   S P+     I++ PG  + V LK   +     PYG C     +++  G + Y YT   C +   Q  I  +C C +   P V + N +FC  +  + +     +N    + E+    I T    L C+       +ND    +   CF PC   SY    S+S WP + +QL+ +        R   +    K A EY ++          R D  + +IL+K   L  K +A           + +N   ++L  VE +++    L    + +GG   +W+G+++++I+E+IEL++R+      SEK L R
Sbjct:   50 SNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPISLRTIRRMYFN-----NESQNLITWLRFIQKFRFEQ---------------DSFMNSIRAFYENLGQDAKKLSHNLEDMLMHC--------RFNRELC-HVSNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNILHSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCT----NDMLNGIKQYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPY--LACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQE-RQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELVIRLTGLVFNSEKGLPR 572
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|H2QAR5|SCNNG_PANTR (Amiloride-sensitive sodium channel subunit gamma OS=Pan troglodytes OX=9598 GN=SCNN1G PE=3 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 8.694e-11
Identity = 109/550 (19.82%), Postives = 204/550 (37.09%), Query Frame = 3 
Query:  159 NSPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSV---IHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSG---YLESIPL----EYHNMLGHDYYDF---VIDCLITFRNGSKHHVDLCQNIG---QWKVTPHAQFINCFSYN-------IKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGN-ETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSL--KRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPT---KSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELL 1721
             +PT K+L++     +C NT   G  RIV +  +  ++LWI F +   A +      L+  F   SV   +H  ++       FP+ T+CN  P  Y+          +  RE       +   Y F    K   +   SS S      +   IPL    +       D++      +   I  +  +  H++  Q +G    + +  H    NC+++N       +          +++ LY+NEE       + F+ +     +GA ++IH+ + +P +      ++   +T + +    +   + PY +C  +  S++ + N    +Y+  +C     Q ++  KC C     P           LP    +  C    H      C+ ++  +   + L C+S             C   C +  +    S++ WP+   + W L  L   +G  V  K                        LNK D     L  ++I   + N   + E    S+   LS  GG   +W+  +++ ++EIIE+ 
Sbjct:   21 QAPTIKELMR----WYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKL------DFPAVTICNINPYKYSTVRHLLADLEQETRE------ALKSLYGFPESRKRREAESWSSISEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEE-----YNPFLVSS----TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDG-SDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQP-----------LPPAANY--CNYQQHPNWM-YCYYQLHRAFVQEELGCQS------------VCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKK------------------------LNKTD-----LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVF 489
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|O97741|SCNNA_RABIT (Amiloride-sensitive sodium channel subunit alpha OS=Oryctolagus cuniculus OX=9986 GN=SCNN1A PE=2 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 3.233e-9
Identity = 79/344 (22.97%), Postives = 137/344 (39.83%), Query Frame = 3 
Query:  735 HAQFINCFSYNIK---AEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYS-YTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSL--KRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWP---TKSWQLTWLNSSRGSNVRSKKELKPYKIAAE--YFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRIS 1733
            H  + NC+++N K   + ++  +  I   L L   T  +  I      + S ++GA +++H  +    ++    NL+PG  T + ++          YG C  N  S++ + N   S YT+ +C     Q  +  +C C  I YP           LP  +++  C+   H+     C+ +++ +    RL C               C  PC   +YE     S WP   ++ W    L+      V +K+      +A    YFKE         LN +   ES  + +V                    + LS LG  +S+W G +++S+VE+ ELL  +S
Sbjct:  276 HPMYGNCYTFNDKNNSSLWMSSMPGINNGLSLTLRTEQNDFIP-----LLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKESLDRLGGDYGDCTQNG-SDVPVKNLYRSKYTQQVCIHSCFQENMVKECGCAYIFYP-----------LPEGVEY--CDYRKHNS-WGYCYYKLQDAFSSDRLGC------------FTKCRKPCSVTNYELSAGYSRWPSVTSQDWVFQMLSLQNNYTVSNKRN----GVAKLNIYFKE---------LNYKANSESPSVTMV--------------------TLLSNLGSQWSLWFGSSVLSVVEMAELLFDLS 554
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q22851|ASIC2_CAEEL (Degenerin-like protein asic-2 OS=Caenorhabditis elegans OX=6239 GN=asic-2 PE=3 SV=1)

HSP 1 Score: 61.2326 bits (147), Expect = 2.401e-8
Identity = 66/295 (22.37%), Postives = 111/295 (37.63%), Query Frame = 3 
Query:  201 HFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNI----SSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLG--------HDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVT--TIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTP 1043
             F   +T+  VP + N  NK S+I WI+ F+F+       L  LI +F  Y       +L      FP  TVCN  P  Y++    S+F +   +      A    + + K+       G Y+    ++ L        +   N++         + Y D + DC  +F        D  + I          +  C+S+N  A     V+   I+  L L      ++      S   ++L+GA + ++   S P ++   I+   G  + V +    NV    PYG C    P
Sbjct:   12 DFSNWSTVAVVPHVANANNKISRIFWIAIFLFVLGMFAYELYILIAKFFSYPATVNTEILFEK-QIFPVVTVCNMNPYKYSVVKSNSAFSSVNTLMTTYSDATVGTFSTDKW-------GLYADNDETYDLDSRAADALVLEANLISDTAKVPALYTYADLIQDC--SFAGIPCSESDFTKFI-------DPVYGACYSFNEDASLNYSVSREGIQFGLKLMLTVTQTKTNGNTDSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKKPYGTCVDREP 289
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|O13262|SCNNC_XENLA (Amiloride-sensitive sodium channel subunit beta-2 OS=Xenopus laevis OX=8355 GN=scnn1b-b PE=2 SV=1)

HSP 1 Score: 60.077 bits (144), Expect = 5.234e-8
Identity = 86/399 (21.55%), Postives = 155/399 (38.85%), Query Frame = 3 
Query:  573 FSLSGYLESIPLEYHNMLGHDYYDFVIDCLI-----TFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTT------IELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGN--ETY--SYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 1724
              LS    ++PL     +G    D ++ CL      ++RN + H  D             A + NC+ +N   E  + +++        L L L+ E       D ++  +++  + A L++H+  SFP +    I  +PGT T + +         APY  C  N  S++ + N  E +  SY+   C     Q E+   C C   +YP+ N +  +C             TN+   +   C+  ++ S+   E           + I  C  PC    Y+   S++ WP+   +  W+      +V S ++   Y I                        + +I + I     N   + E E  ++   LS LGG F  W+G +++ I+E  E+++
Sbjct:  239 LQLSIIFSNVPLSDRVDMGFKAEDLILTCLFGGQPCSYRNFT-HIYD-------------ADYGNCYIFNWGQEGDDTMSSANPGADFGLKLVLDIEQ------DEYLPFLQTT-AAARLILHQQRSFPFVKDLGIYAKPGTETSIAVLVDQLQQMEAPYSSCTVNG-SDIPVQNLYEEFNSSYSIQSCLRSCYQEEMVKTCKCAHYQYPLPNGS-EYC-------------TNNKHPDWVPCYYGLRDSVAIRE-----------NCISLCQQPCNDTHYKMVISMADWPSAGAE-DWI-----FHVLSYEKDSSYDITVN--------------------RNGIIRLNIYFQEFNYRSISESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIII 564
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4V3SD10 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009422 PE=3 SV=1)

HSP 1 Score: 523.087 bits (1346), Expect = 1.680e-173
Identity = 239/531 (45.01%), Postives = 358/531 (67.42%), Query Frame = 3 
Query:  183 LKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEM-GNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEK-------------CFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGRED-KAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRI 1730
            +K EL+ FC+ TTIRGV R+VN  +KS +I+W S  +FL  GL  C+ FL RQ++EY VIHPP+VL+++PSPFPS T+CN RPL+   +    +  ++ PR+FA+  N  + +  + +GD   Y LITS+ S+ GYLES+P E    LGH     +I C++ +  GSK  ++ C  +G+W+   HAQ++NC+SY++  ++ + V TIEL++YL+   N + C+DCF + +KSQLSGA++V+H ++++P+INQE IN+QPG+LTE+++KT  ++ KT PYGRC P+TP  +E+ G   Y Y+EH C+  TIQ +IN++C CNAIE+P  + +L FC A+  F+  GSC+  S      K             C  E++     + CKS VT  +  D++ +C LPC+++SYE+DRS STWPTKSWQL WL +  G  + ++ EL PY+ A +  ++   D +A  +L++ ++LE  L+A++I RPN NLH VEEKEVLSLTS LSQ GGL SIWIG+ ++S++E+ ELL+ +
Sbjct:   37 IKKELILFCQTTTIRGVTRVVNARSKSFQIVWASSVLFLFIGLFTCMFFLTRQYLEYHVIHPPQVLRDTPSPFPSITLCNLRPLASEATKVLEESRIKTPRKFAMDVNNFAAEAFYHKGDVHSYQLITSAISMGGYLESLPPEIRLQLGHHMNQTIIHCMVLYSEGSKRVLNDCHQVGRWRRFVHAQYLNCYSYDLLEKYRDHVRTIELFVYLDVPPNKTSCVDCFSAEIKSQLSGAVVVVHNADTYPDINQEGINIQPGSLTEIKVKTIKHIQKTPPYGRCSPDTPKTIELYGAAPYRYSEHACRMSTIQTQINDRCGCNAIEFPYRSSSLPFCLAMGSFVHEGSCDVQSLQGSGSKVANSTKIGSLKSECLAELEVVKNHVTCKSDVTRHFEGDVVPSCTLPCQFFSYETDRSTSTWPTKSWQLGWLGTRAGRMILNRPELAPYREARDLMRQPNGDVRAQTLLSQTNVLEKNLLAIMIIRPNFNLHNVEEKEVLSLTSLLSQTGGLLSIWIGMNIMSVIELFELLVHL 567
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4E0S173 (FMRFamide-activated amiloride-sensitive sodium channel OS=Fasciola hepatica OX=6192 GN=D915_002784 PE=3 SV=1)

HSP 1 Score: 510.375 bits (1313), Expect = 1.020e-168
Identity = 248/557 (44.52%), Postives = 369/557 (66.25%), Query Frame = 3 
Query:  168 TFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEM-GNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNS------------------------HDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFK-EGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCK 1760
            + KK LK+ELL FC+ TTIRGV RIV   NK+ +  W+   I L  GL  C+ FL RQ++EY+VIHPP+VL+++PSPFPS T+CN RPL+ N +      N++NPR+FA   N  + K  +   D   Y L+TS+ S+ GYLES+PL   ++LGH+  D +I C++    GSK  ++ C+ +G+W+   HAQ++NC++Y++   + + V TIEL++YL+   N + C+DCF S +KSQLSGA++V+H S+++P++NQE IN+QPG+LTE+++KT  +  KT PYGRC PNTP ++++ G+E+Y+Y+EH C+  TIQ +IN +C CNAIE+P +N +L FC A+  F+  G CE ++                        H    E C++E++T  + + CKS VT  +  D++ +C LPC ++SYE+DRS S WPTKSWQL+WL +  G  + ++ +++ Y+ A +     G E +A  IL    +LE  L+A+++ RPN NLH VEEKEVLSLTS LSQ GGL SIWIGL ++S++E++ELL+      L  CC+
Sbjct:   24 SVKKGLKDELLIFCQTTTIRGVTRIVTARNKTFQTAWVCSVIALFIGLFTCMFFLTRQYLEYNVIHPPQVLRDTPSPFPSMTLCNLRPLTSNATKILESLNLKNPRQFASDVNKFAAKTYYYNNDFLSYQLVTSAISMGGYLESLPLNVSHILGHNRSDTIIHCMVLHTEGSKRVLNDCEQVGRWRQFVHAQYLNCYTYDLYEAYRDHVRTIELFVYLDGPMNKTACLDCFSSEIKSQLSGAVVVVHNSDTYPDVNQEGINIQPGSLTEIKVKTIKHTQKTPPYGRCSPNTPVSIQLYGSESYAYSEHACRMSTIQSKINTRCGCNAIEFPYLNGSLPFCLAMSSFVYRGGCEDHTNISRSQSDTTVSPEPNRSPKNSSIHRNPTEICYQELETVKRHVACKSEVTKHFQGDVVPSCTLPCTFFSYETDRSASVWPTKSWQLSWLGTKVGRTLVNRPDMESYRRARKLLTIPGGEAEAKTILASSSVLEQNLLAIMLIRPNLNLHNVEEKEVLSLTSLLSQSGGLLSIWIGLNMMSVIEVLELLVH-----LITCCR 575
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A3Q0KSP8 (Putative amiloride-sensitive sodium channel OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 503.442 bits (1295), Expect = 7.747e-166
Identity = 257/597 (43.05%), Postives = 379/597 (63.48%), Query Frame = 3 
Query:  171 FKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEM-GNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCE---------------------------TNSHDKEQE-----KCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFK--EGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCK-SRRLSLINVSTQETNDHSKKYFLNYTSVTNL 1853
             +K LK E L+FC+ TTIRGV R+VN  NK+ +ILWI   I    GL IC+  L RQ++EY+VIHPP+VL+++PSPFPS T+CN RPLS   +   N+  +++PR+FAI  N  + K  +   D   Y  +TS+ S+ GYLES+P      LGH+    VI C++    GSK  ++ C  +G+W+   HAQ++NC++Y+I   +   V TIEL++YL+E  N++ C DCF S +KSQLSGA++ +H + ++P+INQE IN+QPG+LTE+++KT  +  KT PYGRC P+TP+ + + G+E Y+Y+EH C+  TIQ +IN+ C CNAIE+P +N +L FC  +  F+K G+C+                            N   K  E     +C  E++    R+ CKS VT  Y  D++ +C LPC +++YE+DRS STWPTKSWQL+WL++  G  V ++ +L  Y++A E     EG E +A E L+K ++LE  L+A+++ RPN N+H+V+EKEVLSLTS LSQ GGLFSIWIGL ++S++E++EL+  +    + RC + S+R  L     ++T   + K   N  S T +
Sbjct:   16 LRKGLKKEFLYFCQTTTIRGVTRVVNARNKTLQILWIGSVILFFGGLFICMFILTRQYLEYNVIHPPQVLRDTPSPFPSLTLCNLRPLSSEANIILNKYKLKSPRQFAIDLNNFAAKAYYYSNDIHSYQQVTSAVSMGGYLESLPQIVVPKLGHNLSHTVIHCMVIHAEGSKRVMNECIQVGRWRRFVHAQYLNCYTYDIHEIYRNHVRTIELFVYLDESMNITSCSDCFSSEIKSQLSGAVVTVHNAETYPDINQEGINIQPGSLTEIKVKTIKHTQKTPPYGRCSPDTPTKINLYGSEVYAYSEHACRMSTIQAKINSLCGCNAIEFPYINESLPFCLEMSSFVKIGNCDIQHPIIQNYTIHNSPSNQNYTLLSSVNQNQKTKPHEMPFNFECLSELEAVKNRVLCKSEVTKHYQGDVVLSCTLPCAFFAYETDRSTSTWPTKSWQLSWLSTRAGKKVANRPDLVGYRLAKEKLDSSEG-EKEAEEFLSKSNVLERNLLAIMLIRPNFNVHKVDEKEVLSLTSLLSQSGGLFSIWIGLNMMSVIEVVELIFHL----ITRCRQFSKRKRLRRTQKKQTTCDTPKSLTNTNSETGV 607
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A564Y5L5 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS2931 PE=3 SV=1)

HSP 1 Score: 488.034 bits (1255), Expect = 1.533e-160
Identity = 239/540 (44.26%), Postives = 341/540 (63.15%), Query Frame = 3 
Query:  162 SPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNL-EMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCE----------TNSHDKEQE--KCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGRE------DKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 1724
            +PT+K+    ELL FC+ TTIRGVPRIVN  +K  + +W++F I L  GL  C+  L RQ+ +Y VIHPPRVL+++PSPFPS T+CN RP+S        +   R+PR FA   N  +    + R     Y +I+++ S+ GYLES+P +Y   LGH   + VI C+I F+ GS    D C+ +G+W+   HA ++NC + ++         ++EL+ YLNE  +   C DCF +++KSQLSGA++V+H + ++P IN+E IN+QPGTLTE++ K   N+ K  PYGRC  +T + +      +Y+Y+E+ C+  TIQ EIN KC+CNAIE+P+VN +L FC ++  F+K   C            NS +   E   C +++ T+ ++L CKS VT  Y  D++  C LPC +YSYE+DRS STWPTKSWQL WLN+S G  V    E+  Y+ A E   +  +       + + IL + + LE  L+A+ + RPN NLH+V EKEVLSLTSFLSQ GGL SIWIGLT+I +VEI+EL++
Sbjct:   10 TPTYKQ----ELLRFCQTTTIRGVPRIVNAKHKGIRSVWLAFVIILFMGLFTCMILLARQYFDYDVIHPPRVLRDTPSPFPSITLCNLRPISTAGIKRIKELRFRDPRAFARNVNNFAAGLYYYRNRSHDYEIISNAISMGGYLESLPKDYSYSLGHMKNESVIQCMIQFQEGSSIIADYCERVGRWRRILHALYLNCHTLDVDPNISHRAVSLELFSYLNERHDEVICHDCFAADIKSQLSGAVIVVHSAQTYPEINKEGINVQPGTLTEIKFKAIENIQKEPPYGRCDRDTKTEIPSHDGASYAYSEYGCRMYTIQDEINKKCNCNAIEFPIVNGDLPFCMSMVDFVKEDMCNHEQMVKSVQMPNSTEPSNEFLVCEQQLNTAREKLICKSQVTGEYQGDVVPACTLPCSFYSYETDRSTSTWPTKSWQLAWLNTSIGRTVLQMSEMSEYRRALELLNQSSDVNKTTTREILRILEQNNALERNLLAITVVRPNWNLHKVAEKEVLSLTSFLSQTGGLLSIWIGLTMICVVEILELII 545
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A068YCL6 (FMRFamide activated amiloride sensitive sodium OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000763100 PE=3 SV=1)

HSP 1 Score: 481.871 bits (1239), Expect = 3.349e-158
Identity = 235/532 (44.17%), Postives = 333/532 (62.59%), Query Frame = 3 
Query:  186 KNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLE-MGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQE------------KCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGRED------KAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 1724
            K ELL FC+ TTIRGV RIVN+ NK  + LW++F I L  GL  C+  L  Q+ +Y VIHPPRVL+++PSPFPS T+CN RPLS        Q   R+PR+FA   N  +    F R     Y L++S+ S+ GYLES+P      LGH   + VI C++ +  GS   ++ C+ +G+W+   HA ++NC S++I       V TIEL+ YLNE  +   C DCF S +KSQLSGA++V+H ++++P++NQE INLQPGTLTE+++K   N+ K  PYGRC  +TP+ +    N +Y+Y+E+ C+  TIQ EIN  C+CNAIE+P++N +L FC ++  F+K   C      K+ E             C  ++  +  R+ CK+ V   +  D++ TC LPC +YSYE+DRS STWPTKSWQLTWL++  G  +    E+  Y+ A E   +   D      + + IL +   +E  L+A+++ R N NLH+V EKEV SLTSFLSQ GGL SIWIGLT+I +VE++EL++
Sbjct:   14 KQELLRFCQTTTIRGVSRIVNSRNKGIRSLWLTFVICLYIGLFTCMILLASQYFDYDVIHPPRVLRDTPSPFPSLTLCNLRPLSPPGMKRIRQLQFRDPRDFAKNLNEFAAGLYFYRNRSHDYELVSSAISMGGYLESLPKGSSYTLGHLQNETVIQCMVLYLEGSSRIIEPCEKVGRWRHFFHALYLNCHSFDIDPSISRRVLTIELFSYLNERHDEVECHDCFASEIKSQLSGAVVVVHTASTYPDVNQEGINLQPGTLTEIKIKAIENIQKEPPYGRCTRDTPTEIPGHDNMSYAYSEYGCRMYTIQAEINENCNCNAIEFPIINNSLPFCMSMVDFVKENRCVYEKMVKQAEMRNATGPSEEFLTCEAQLNMARDRILCKALVMQEFQGDVVPTCTLPCAFYSYETDRSTSTWPTKSWQLTWLSTDVGRTILEMPEMVEYRRAVELLSQHDGDTGANKQEVLRILKQNSAVERNLLAIIVVRSNFNLHKVAEKEVFSLTSFLSQTGGLLSIWIGLTMICVVEVLELII 545
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF92])

HSP 1 Score: 61.2326 bits (147), Expect = 9.903e-10
Identity = 65/321 (20.25%), Postives = 125/321 (38.94%), Query Frame = 3 
Query:  921 FPNINQEAINLQPG--TLTEVRLKTFFNVMKTAPYGR-----CKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDII---DTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLNYTSVTNL 1853
             P+  ++ I++ PG  T T +R+    N+++  P+            P NL       SY+   C +  +  +  + C C    +P ++ N + C  L I +                           + C + V  LY ++ +   + C  PC    ++   S + WPT  ++                        A +  E +EDK   +    D   +  + + I     N   +EE     L +F+S +GG   +WIG++ ++  E++ELL+ I+  +L +     R  LI+ S ++  D + +Y  + T   +L
Sbjct:    1 MPSPLEKGISVSPGFSTTTGIRMT---NILRADPFNNKSCLSSDDIDPENLYRKRYNVSYSRTTCMDSCLAHKQVDMCGCLEYRFPNID-NRTVCDILDIDV---------------------------IRCLNKVQSLYQDNKLGCSEKCRPPCNEEVFKLSISSARWPTDDYE------------------------AHFLDELKEDKGFVLPANADA-RAYFVKLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALHLLRKVT---RTGLIDNSAEQPADTNPRYLDDITLTGDL 262
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2])

HSP 1 Score: 55.0694 bits (131), Expect = 7.964e-8
Identity = 117/561 (20.86%), Postives = 204/561 (36.36%), Query Frame = 3 
Query:  192 ELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHR---------PLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDC---LITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYN-IKAEFIEEVTTIE---------LYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGR--CKPN---TPSNLEMG-NETYSYTEHLCKEKTIQLEINNKCHCNAIEYP-VVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVV-INRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLIN 1784
            ++  F + TT  G  R+  T     ++ W+ F +         L  L+ Q+    +    ++       FP  T+CN            L        N  N  +PR  + + N           +   + ++ +  +   Y E +         H   D ++ C    +  RN     +        W  T +  F NC+ +N +K    E+V             L L LN E N       ++  + ++++G  + I      P   Q+ I + PG  T +++ T     +  P+    C+ +   +  NL  G N TYS     CK   +      +C C     P +  RN+  C+ L   I    C   ++D      FE+   S  R EC  S                C   S++   S + WP +S+++T                   K A  YF   R    I   + +  + S+ IA V +     +   V+E    +  S LS +GG   +WIG++ ++  E+IEL+  I   + +R   S+++  IN
Sbjct:   14 QINQFLQETTAHGFGRLGATAGSKWRLYWVMFCLAAYCVFVWQLVGLVNQYNSKPIKTRTQLKHAQKLDFPVVTICNMNVLRASRLPPKLRTKFDQIINNTNKTSPRNSSNSRNAFVDPQDLSFEETKKFEILHAVTAHDDYRELVSA------AHQLEDILLSCNFNGVNCRNSKDPTIPT-----YWTQTWNDNFGNCYMFNSVKTHNGEKVDLYSSSVPGESNGLTLQLNLEQNE------YLEGI-TEVAGMKVTISDQGVLPFPGQQGIRIMPGQSTGIQM-TKLQTRRIDPFKNRSCESSNEMSDKNLFFGYNMTYSIMA--CKYSCLNARKIERCGCTNYNTPEMQKRNIPLCNRLNSTII--DCLNKAYDT-----FED--GSCDR-ECPPS----------------CSEVSFDLTVSSARWPARSFEVT-------------------KYA--YFLRVRVLNKIASSSSKYFVNSENIAQVHVYYGELDYLLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELVCVILANMSNR---SKKIVHIN 503
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFR0])

HSP 1 Score: 55.0694 bits (131), Expect = 1.084e-7
Identity = 44/192 (22.92%), Postives = 82/192 (42.71%), Query Frame = 3 
Query: 1287 LECKSSVTVLYHNDII---DTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLNYTSVTNL 1853
            + C + V  LY ++ +   + C  PC    ++   S + WPT  ++                        A +  E +EDK   +    D   +  + + I     N   +EE     L +F+S +GG   +WIG++ ++  E++ELL+ I+  +L    K  R  LI+ S ++  D + +Y  + T   +L
Sbjct:  992 IRCLNKVQSLYQDNKLGCSEKCRPPCNEEVFKLSISSARWPTDDYE------------------------AHFLDELKEDKGFVLPANADA-RAYFVKLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALHLLR---KVTRTGLIDNSAEQPADTNPRYLDDITLTGDL 1155

HSP 2 Score: 50.0618 bits (118), Expect = 4.089e-6
Identity = 74/358 (20.67%), Postives = 135/358 (37.71%), Query Frame = 3 
Query:  555 SLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQ--WKVTPHAQFINCFSYNIKAEFIEEVTTI----------ELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPG--TLTEVRLKTFFNVMKTAPYGR-----CKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDII---DTCFLPCEYYSYESDRSISTWPTKSWQ---LTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDIL 1553
            +L T    LS  L + P +     GH +YD V+ C  T+R         C N  +  W    H ++ NC+ +N   ++  E   I           L L LN E +       ++  + S  +G  ++I      P+  ++ I++ PG  T T +R+    N+++  P+            P NL       SY+   C +  +  +  + C C    +P ++ N + C  L I +                           + C + V  LY ++ +   D C  PC    ++   S + WPT  ++   L  L   +G  + +  + + Y +  + F E    + IE     ++L
Sbjct:  263 TLKTEELVLS--LATKPEDMLMEAGHQFYDMVLSC--TYRGIP------CTNYTENLWSRFWHYRYGNCYVFNSGKDWQGEPKPILRSNKPGPASGLTLELNAEQHE------YVGQL-SHEAGMRVLISTQGEMPSPLEKGISVSPGFSTTTGIRMT---NILRADPFNNKSCLSSDDIDPENLYKKRYNVSYSRTTCMDSCLAHKQLDMCGCLEYRFPNID-NRTVCDILDIDV---------------------------IRCLNKVQSLYQDNKLGCSDKCRPPCNEEVFKLSISSARWPTDDYEAHFLDELKEDKGFVLPANADARAYFVKLQIFYEELNHEVIEEYRSYEVL 572
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO39877 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8S3])

HSP 1 Score: 54.6842 bits (130), Expect = 1.103e-7
Identity = 93/412 (22.57%), Postives = 163/412 (39.56%), Query Frame = 3 
Query:  174 KKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQF---------IEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEF--IEEVTT----IELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPY-----GRCKPNTPSNLEMG--NETYS-YTEHLCKEKTIQLEINNKCH---------CNAIEYPVVNRNLSFC---------SALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKR 1286
            K L+KN    F   TT+ G   +++++    ++LW +   F   GL +    L+  +         +   V  P  VL      +P+ T+CN             Q  MR  R    AA    ++YL D+ D    SL   + +   +      E   + GH+  D + +C   F N    H D        + T +++ + C+++N  A    I + TT      L L LN E+      D +        +G  L +H  N  PN++++A ++ PG LT +R++    +   +PY      R   N P     G   E YS      CK + + + +N + +         C A+ Y +    LS           S  P+ + F    T++  K Q++   +I+ +L++
Sbjct:   29 KTLIKN----FSSYTTLHGFHFLLDSSPMPRRVLWTALVGF---GLVVFFIQLVMSYGKLRARESILAKGVERPMNVL------YPAVTICN-------------QNMMRKSRITGTAA----QRYL-DQLDHIKASLSRVNRTNERFETE---EMVRLYGHNITDMLWEC--NFMNKPCSHKDFAM-----RYTSYSRGL-CYTFNAGANGSPIGQATTSGTRTSLSLRLNAES------DEYYGPFSYDATGFKLAVHDQNEIPNMDEDAFDISPGFLTNIRIRREKEINLPSPYRSECGSRDLSNAPKYSMSGCIYECYSKIIADKCKCRVLGMALNVELNPAMCDCPKPCRALHYKI---QLSLAYFPSDHLWDSIFPVLLNF----TDTTGKSQDEVLLQIQEALRK 385
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37453 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFR1])

HSP 1 Score: 49.2914 bits (116), Expect = 5.066e-6
Identity = 34/124 (27.42%), Postives = 60/124 (48.39%), Query Frame = 3 
Query: 1482 IAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLNYTSVTNL 1853
            I A +  E +E+K   +    D   +  + + I     N   +EE     L +F+S +GG   +WIG++ ++  E IELL+ I+  +L    K  R+ LI+ S ++  D +  Y  + T   +L
Sbjct:  473 IDAHFLDELKEEKGFVLPANADA-RAYFVKLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASEFIELLIVIALHLLR---KVTRIGLIDNSAEQPADTNPCYLDDITLTGDL 592
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000069611.1 (SMESG000069611.1)

HSP 1 Score: 1242.64 bits (3214), Expect = 0.000e+0
Identity = 605/607 (99.67%), Postives = 606/607 (99.84%), Query Frame = 3 
Query:   33 MHGNNLLQEPQLLKNVCWFCKSSVKTTLEDFHSNQIQEEAILNSPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLNYTSVTNL 1853
            MHGNNLLQEPQLLKNVCWFCKSSVKTTLEDFHSNQIQEEAILNSPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALP FIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEG+EDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLNYTSVTNL
Sbjct:    1 MHGNNLLQEPQLLKNVCWFCKSSVKTTLEDFHSNQIQEEAILNSPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPTFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGKEDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLNYTSVTNL 607
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000044381.1 (SMESG000044381.1)

HSP 1 Score: 551.592 bits (1420), Expect = 0.000e+0
Identity = 269/530 (50.75%), Postives = 365/530 (68.87%), Query Frame = 3 
Query:  135 QIQEEAILNSPTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLM 1724
            ++  E I+N   FK + K E L FC+NTT+RGVPRIV +     + LW++FFI L  G  +C+ FL  Q++EY+VIHPPR+L ++ +PFPS TVCN+RP+  NI     +RN+++PREFA + N  + KY + +    +Y   +S  ++  YLES+P    N LGHD  D +I C +T+ NGS  H  +C +IG+W+V  HAQ+INC+SYN+   +     T+ELY YL++    S C+DCF S+VKSQLSGAL++IH+  +FPN N + INLQPGTLTE++LK F NV K  PYGRC   +P  +++ N+ YSY+EH CK  TIQ +IN +C CNAIEYP+ N NLSFCS LP FI+   C     D+   KC  ++   +K++ CKS+V+  Y  DI+ +C LPC+ YSYESDRS S+WPTK+WQ+ W+ S+    +R K ELK Y  A   +  G  +K+  ILN+Q+ILE  L+AV+INRPN N+H VEEKEVLSLTSFLSQ GGL SIWIGLT+ISIVE+IE+L+
Sbjct:    5 ELDSEIIIN---FKTISKEEFLRFCENTTLRGVPRIVKSRKSHIRHLWLTFFILLFIGFMVCIIFLCYQYLEYNVIHPPRILSDNKAPFPSLTVCNYRPMKRNILEIMKKRNIKDPREFAHSINKYAIKYYYKKNLGKNYQRASSIMNMGAYLESVPNRTFNELGHDEQDLIIYCQVTYMNGSSPHYKVCSDIGKWRVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGCNAIEYPIDNFNLSFCSNLPRFIEGKLCHD---DQSDMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIKSNAARRLRKKPELKGYIDAYREYLNGSVNKSFRILNQQNILEQNLLAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLL 528
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000028687.1 (SMESG000028687.1)

HSP 1 Score: 543.888 bits (1400), Expect = 0.000e+0
Identity = 254/516 (49.22%), Postives = 363/516 (70.35%), Query Frame = 3 
Query:  174 KKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELL 1721
            ++++K E L FC+NTTIRGVP+I+ + +K  + +W++ FI L +G ++C  FL++Q+  Y VIHPPR+L NS +PFPSFTVCN RPL+ NI + F  +N++ PREFA   N  + KY +++ +   Y   +S   + GYLES+P + +  LGH   D +I C +T+  GSK H   C  +G+W+   HAQ++NC+ +++         T+E++LYL+E  N + CIDCF S+VKSQLSGAL++IH+SN+FPN N++ INLQPGTLTE++LKT  N  K  PYGRC   TP  +++  E Y+Y+E LCK  TIQ ++N+ C+CNAIEYP    +L FCSALP F +  SC    +D+   KC  E+K ++K++ CK+   ++Y+NDI+ +C LPC +YSYE+DRS STWPTKSWQL W+++     +  K+EL  Y+ A +  ++G   +A++ILNK++ +E K++AV+INRPN N+H VEEKEVLSLTSFLSQ GGLFSIWIG+TL SIVEI E+ 
Sbjct:   39 RQVIKEEFLRFCENTTIRGVPKIIKSKHKPLRYMWMTCFILLLSGFSVCFIFLLKQYFAYDVIHPPRILTNSQAPFPSFTVCNLRPLARNIDTIFKLKNLKTPREFAKNVNNYAIKYFYNKNNLTLYGHASSIMLMGGYLESVPNKSYVELGHKKQDLIIHCRVTYMIGSKPHSKDCDELGKWRRIIHAQYVNCYMFDLIESLSNATNTLEMFLYLDESINQATCIDCFSSDVKSQLSGALILIHRSNTFPNFNRDMINLQPGTLTEIKLKTIHNRHKLPPYGRCSNKTPKWIKVFGELYAYSEDLCKLITIQGDLNHFCNCNAIEYPFNYSSLKFCSALPSFSQRVSCNNRLNDR---KCETELKNTVKQISCKAKACLIYNNDIVPSCKLPCSFYSYETDRSTSTWPTKSWQLQWISTKAAKPLLDKQELDNYRYAVKLQEKGNYSEALKILNKENTMEQKILAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLFSIWIGMTLFSIVEIFEMF 551
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000078360.1 (SMESG000078360.1)

HSP 1 Score: 519.62 bits (1337), Expect = 1.385e-175
Identity = 256/546 (46.89%), Postives = 364/546 (66.67%), Query Frame = 3 
Query:  180 LLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAAN-YVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNSHDK--EQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIGLTLISIVEIIELLMRISE--KVLDR-CCKSRRLSLINVSTQE 1799
            LLK+EL+ FC+NTT+RG+PRI+   +++ +ILWI+F + L  GL + + FL +Q++EY+VIHPP +L +   PFPS ++CN RPLS     F  + N RNPREF    N YV+ K+ +++  K +Y+  T++ S++GYLES+P +  + LGH   + VI CL+ +  GSK  +  C ++G W  T HA +INC S  I  E    + ++ +Y+YL+E    + C DCF+  +KSQLSGAL+V+H S+++P+INQEA+NLQPGTLTE  LK   N  K  PYGRC   T +++++ N  Y Y+EH C+  TIQ EIN+ C CNAIEYP+ N +L FCSALP FI    C ++   K    + C  EI      L CK+++T+ Y +D++  C LPC +YSY SDRS STWPTKS+QL  +NS +   +R+K++ KPY        EG E +A+E+L K +ILE  L+ ++INRPN  +H VEEKEVLSLTS+LSQ GGLFSI+IGL++IS+VE +ELL+   E  KV  R C +  R S +N +T++
Sbjct:   75 LLKHELIAFCQNTTMRGIPRIIKAQSRNLRILWITFVVILFIGLLLSMLFLTKQYLEYNVIHPPVILPDQEPPFPSISLCNLRPLSRFGLEFLKKNNWRNPREFGNNLNVYVANKWYYNQSTKHYYTQFTTAISMNGYLESVPFDVLDKLGHSLDELVIHCLVIYNVGSKSEIQKCGSLGHWTKTTHALYINCHSLTIYPELRNHIKSVIMYIYLDEILKTNLCADCFMQELKSQLSGALVVVHTSDTYPDINQEAVNLQPGTLTEFNLKFILNKNKAPPYGRCSKYTETHIKLHNHNYIYSEHACQLTTIQREINDICRCNAIEYPIFNLSLPFCSALPSFISHKDCISSKTKKVLNNKTCDMEILKVFNNLGCKNNITIKYRSDVVAKCTLPCSFYSYASDRSTSTWPTKSFQLNLINSEKARELRNKEDFKPYLKLINISNEGHETEALEMLEKLNILERNLLGIMINRPNNKVHVVEEKEVLSLTSYLSQTGGLFSIFIGLSIISVVEFLELLIHCVEAFKVTRRKCAQKHRNSAVNEATEK 620
[Close]
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000037525.1 (SMESG000037525.1)

HSP 1 Score: 498.819 bits (1283), Expect = 8.212e-169
Identity = 260/512 (50.78%), Postives = 347/512 (67.77%), Query Frame = 3 
Query:  165 PTFKKLLKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFLIRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNPREFAIAAN-YVSKKYLFDRGDKGHYSLITSSFSLSGYLESIP-LEYHNMLGHDYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEFIEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNINQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYTEHLCKEKTIQLEINNKCHCNAIEYPV-VNRNLSFCSALPIFIKFGSCE------TN-SHDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDRSISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEILNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFS 1670
            P   + +K E L FC+NTTIRGV RIV +T+K    LW+ FFI LC GL +C+  L+ Q+++Y+VIHPPRVL N  SPFPSFT+CN RPLS ++ SF     +RNPREFA   N Y   +YL  + D  HY+  T+  S+ GYLES+P   Y   LGH   + VI C + + +G++  +D C ++G+W+   H Q+INC+SY +   F  +  T+EL++YL EE N + CIDCF SNVK+QLSGA LVIH   SFP+INQ ++NLQPGTLTEV+LKT  N+MKT PYGRC   T  +L M  E Y+YTE  CK  T Q +IN +C C AI++P   + ++ FC++LP FI   SC       TN S DK+   C  +I+ +L+R+ CK++VT  YH D ++ C+LPC +YSYE+DRSIS+WPTKS+ L W+ SS    +++K ELK Y+ A +   +G E  A +IL  Q+ILE KL+ +VIN+P+ NLH VEEKEVLSLTSFLSQ GGLFS
Sbjct:   64 PKRGECMKKEFLLFCQNTTIRGVSRIVKSTDKKIFFLWLGFFIILCIGLLVCMILLLLQYLDYNVIHPPRVLSNKESPFPSFTICNLRPLSPDVRSFLANEKLRNPREFASRLNQYAVSRYL-KKNDSFHYAASTAISSMGGYLESMPNTSYFKELGHGLDEMVIFCKVNYVDGNQPILDECPSVGRWRTILHPQYINCYSYVLYERFSLKTNTVELFVYLGEEVNTTECIDCFFSNVKTQLSGAALVIHNRASFPDINQYSVNLQPGTLTEVKLKTIKNIMKTPPYGRCSKYTQEHLYMYKEDYTYTEGACKFVTFQQKINEECKCIAIDFPFNESSSMPFCTSLPHFIHKKSCPSIKSKLTNVSLDKD---CVSDIEKALERIICKNNVTRRYHGDRVEGCYLPCTFYSYETDRSISSWPTKSYHLKWIQSSAAKAIKNKPELKKYREAIKILNDGNEANAYDILASQNILEKKLVGIVINKPDYNLHVVEEKEVLSLTSFLSQSGGLFS 571
The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
SCNN1G4.851e-619.01sodium channel epithelial 1 gamma subunit [Source:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic-21.887e-922.37Degenerin-like protein asic-2 [Source:UniProtKB/S... [more]
mec-42.154e-820.63Degenerin mec-4 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
mec-42.154e-820.63Degenerin mec-4 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
delm-13.181e-820.30DEgenerin Linked to Mechanosensation [Source:UniP... [more]
del-41.747e-719.08DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P9183... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
scnn1b5.802e-820.80sodium channel, non voltage gated 1 beta subunit [... [more]
scnn1b6.018e-721.13sodium channel, non voltage gated 1 beta subunit [... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Asic51.531e-820.60acid-sensing (proton-gated) ion channel family mem... [more]
Asic54.032e-822.66acid-sensing (proton-gated) ion channel family mem... [more]
Scnn1a1.097e-720.82sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a1.143e-720.82sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a1.713e-720.82sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q25011|FANA_CORAP3.265e-2522.54FMRFamide-activated amiloride-sensitive sodium cha... [more]
sp|H2QAR5|SCNNG_PANTR8.694e-1119.82Amiloride-sensitive sodium channel subunit gamma O... [more]
sp|O97741|SCNNA_RABIT3.233e-922.97Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|Q22851|ASIC2_CAEEL2.401e-822.37Degenerin-like protein asic-2 OS=Caenorhabditis el... [more]
sp|O13262|SCNNC_XENLA5.234e-821.55Amiloride-sensitive sodium channel subunit beta-2 ... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4V3SD101.680e-17345.01Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A4E0S1731.020e-16844.52FMRFamide-activated amiloride-sensitive sodium cha... [more]
A0A3Q0KSP87.747e-16643.05Putative amiloride-sensitive sodium channel OS=Sch... [more]
A0A564Y5L51.533e-16044.26Uncharacterized protein OS=Hymenolepis diminuta OX... [more]
A0A068YCL63.349e-15844.17FMRFamide activated amiloride sensitive sodium OS=... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO376679.903e-1020.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO421377.964e-820.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374521.084e-722.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO398771.103e-722.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374535.066e-627.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000069611.10.000e+099.67SMESG000069611.1[more]
SMESG000044381.10.000e+050.75SMESG000044381.1[more]
SMESG000028687.10.000e+049.22SMESG000028687.1[more]
SMESG000078360.11.385e-17546.89SMESG000078360.1[more]
SMESG000037525.18.212e-16950.78SMESG000037525.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028029 ID=SMED30028029|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=2269bp
AAAAACTAATATTTTAAAAATTCATTTTCATAATGCACGGCAATAATCTG
CTCCAAGAACCGCAATTACTGAAAAATGTCTGCTGGTTTTGCAAGAGCTC
AGTAAAAACGACTCTGGAGGATTTTCATTCAAATCAAATCCAGGAAGAGG
CGATTTTAAATTCTCCGACGTTCAAGAAATTATTAAAAAATGAACTGCTT
CATTTCTGTAAGAACACAACAATCCGTGGAGTTCCGAGAATTGTCAACAC
TACCAACAAATCGAGTAAAATTCTATGGATAAGTTTTTTTATTTTTCTCT
GTGCCGGTTTGACAATCTGTCTGACATTTCTCATCCGACAATTTATTGAA
TATAGTGTCATTCATCCACCAAGAGTTCTTCAAAACAGCCCGTCTCCGTT
TCCGTCATTTACTGTCTGTAATCATCGGCCATTGAGTTACAATATCAGCA
GTTTTTTCAATCAAAGAAACATGAGAAATCCTCGAGAATTTGCAATAGCG
GCCAACTACGTGTCGAAAAAGTATCTATTTGATCGTGGAGATAAAGGTCA
TTATAGTTTGATTACTTCAAGCTTTTCTTTGAGCGGTTATTTGGAAAGCA
TTCCATTGGAATATCATAATATGCTTGGACACGACTACTACGATTTTGTT
ATTGACTGTTTAATAACATTTCGTAATGGGAGCAAACACCATGTTGATCT
TTGTCAAAATATCGGACAATGGAAAGTTACCCCCCATGCTCAATTCATCA
ACTGCTTTTCCTACAACATTAAAGCTGAATTTATTGAAGAAGTGACAACC
ATAGAACTCTATTTATATTTGAATGAAGAGACCAATGTGAGTCGCTGCAT
TGACTGTTTCATTTCCAATGTCAAATCTCAATTGTCCGGGGCTCTTTTAG
TAATTCATAAAAGCAATTCTTTCCCTAATATTAATCAAGAAGCCATCAAT
TTGCAGCCTGGTACACTTACTGAAGTTCGTTTGAAAACATTCTTTAATGT
TATGAAAACGGCTCCGTATGGAAGATGTAAACCAAATACACCAAGTAACT
TGGAAATGGGAAACGAAACTTACAGTTATACTGAACACCTTTGTAAAGAA
AAGACTATTCAACTGGAGATTAATAACAAATGCCATTGTAACGCTATTGA
ATACCCTGTAGTGAATCGTAACCTATCCTTTTGTAGTGCTTTACCAATCT
TTATAAAGTTTGGAAGTTGTGAAACAAACAGTCACGATAAAGAACAAGAA
AAATGTTTTGAAGAAATTAAAACTTCATTAAAACGATTAGAGTGCAAATC
AAGCGTGACAGTTCTTTATCACAATGACATCATTGATACATGCTTTCTGC
CGTGTGAGTATTACAGTTATGAGTCGGATAGGTCTATTAGTACTTGGCCA
ACAAAGTCTTGGCAATTGACTTGGTTGAACTCGAGCCGAGGCTCGAATGT
TCGCAGTAAAAAGGAGTTAAAGCCTTATAAAATTGCCGCCGAATACTTTA
AAGAAGGCAGAGAGGACAAAGCAATTGAGATACTAAACAAGCAAGATATT
TTAGAAAGTAAATTAATTGCGGTTGTAATCAACAGACCGAATAAGAATCT
TCATCGAGTCGAAGAAAAAGAGGTTTTATCTTTGACAAGTTTTCTAAGTC
AACTGGGAGGATTATTTAGCATCTGGATTGGTTTGACACTGATAAGTATA
GTGGAAATCATCGAGCTTCTCATGAGAATCTCTGAAAAAGTCCTCGATAG
ATGCTGTAAAAGTCGTCGGTTATCACTGATCAATGTGAGCACCCAAGAAA
CAAATGATCATTCGAAAAAATATTTTCTCAATTACACTTCTGTGACAAAT
TTGTGAGACTGAATATTTATTTCTTTTTTCGAATTGAGCAAGTTTTGGCT
AATGAGAAATCGCGCTGAATTTATTATATTTTTATTCGCTACTGATTATC
AATGGTTTATTTATCATTATCTTTATTGCAATTTCGTTGTTTGTAAGAAT
TCATTTTGTCGTAAACAACAATAAATGTTGATGTTCTAAACAAATTTGAT
GTGCTAATAGACTGCTGTGTTTTTGAGGTAAACACAGAAATGTTATTTCT
AGAATTGTGTAGATTCTGATAACATCGACATTGAAGTAATGAAAGAGAAG
AAAAGAAAAGAATGATTTGTTGTAGCAAAAATAGTAATTGTTTCTAAAAT
AGTGATTACTTGTCTGATCAACTCTTAGAATTCAAACAAAAAAATAATTT
AATAAGACTTTGCCTCGCT
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protein sequence of SMED30028029-orf-1

>SMED30028029-orf-1 ID=SMED30028029-orf-1|Name=SMED30028029-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=608bp
MHGNNLLQEPQLLKNVCWFCKSSVKTTLEDFHSNQIQEEAILNSPTFKKL
LKNELLHFCKNTTIRGVPRIVNTTNKSSKILWISFFIFLCAGLTICLTFL
IRQFIEYSVIHPPRVLQNSPSPFPSFTVCNHRPLSYNISSFFNQRNMRNP
REFAIAANYVSKKYLFDRGDKGHYSLITSSFSLSGYLESIPLEYHNMLGH
DYYDFVIDCLITFRNGSKHHVDLCQNIGQWKVTPHAQFINCFSYNIKAEF
IEEVTTIELYLYLNEETNVSRCIDCFISNVKSQLSGALLVIHKSNSFPNI
NQEAINLQPGTLTEVRLKTFFNVMKTAPYGRCKPNTPSNLEMGNETYSYT
EHLCKEKTIQLEINNKCHCNAIEYPVVNRNLSFCSALPIFIKFGSCETNS
HDKEQEKCFEEIKTSLKRLECKSSVTVLYHNDIIDTCFLPCEYYSYESDR
SISTWPTKSWQLTWLNSSRGSNVRSKKELKPYKIAAEYFKEGREDKAIEI
LNKQDILESKLIAVVINRPNKNLHRVEEKEVLSLTSFLSQLGGLFSIWIG
LTLISIVEIIELLMRISEKVLDRCCKSRRLSLINVSTQETNDHSKKYFLN
YTSVTNL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000140anterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: molecular function
TermDefinition
GO:0005272sodium channel activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 360..377
score: 29.33
coord: 286..304
score: 25.05
coord: 229..245
score: 22.82
coord: 119..135
score: 35.76
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 58..562
e-value: 6.3E-58
score: 196.8
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 54..590
NoneNo IPR availableTMHMMTMhelixcoord: 80..102
NoneNo IPR availableTMHMMTMhelixcoord: 541..563