Polypeptide N-acetylgalactosaminyltransferase

Query:  229 LVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEG--GEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            L DWH+   I  + +R G GEQG    +  AE  +Q   Y+ENG++ Y SDKIS+ RSL DIRHP C + +YL++LP+ S+IIPFH E WS L+RTV SV+ R+P  L+ E++LVDD S +  L+K LE ++   +P  ++LRT  R+GLIRTR+LGA  A GDV+ FLDSH EANVNWLPPLL+ IA+N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  ++ P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R  L+CK+F WFM ++A+DL   YP +EP     GEI+        +C D K    G  + L  C+    +      Q F  +W+ +I+P D    +  C D+  H     V L+ CH  +GNQ +KY+ + + +    SG C++   +   I + TCN +   Q+W++   N T L+K +
Sbjct:   71 LKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQA--YRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMA-LFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNV---GTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHT--SPVTLYDCHSMKGNQLWKYR-KDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFN 601          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKL 1824
            DWH+Y  I++E  R G GE G     P  EE+     Y+ENG++ + S+ I+++RSL DIRH  CK   YL+ LP+ S+IIPFH E W+ L+RT+ S+I R P  LI E+ILVDD S +  L+  LE ++   +   +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDEF EY+Y RRP  R+    +++ Q  +R++L CK+F WFM  VA+D+   YP +EP P   GEI+    N   +C+D K   +G  + L  C+    +     EQ F   W+ +I+P +    R  C D+  H     V L+ CHG +GNQ + Y+ + + +    S  C++ +PA K I +  C+     Q+WI+  +NMT L+K 
Sbjct:   51 DWHDYESIQKEAMRSGKGEHGKPY--PLTEEDHDDSAYRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHLKDKLEEYMAR-FSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAAN---LCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISH--NSPVTLYDCHGMKGNQLWGYR-KDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKF 578          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKL 1824
            DWH+Y  I++E  R G GE G     P  EE+     Y+ENG++ + S+ I+++RSL DIRH  CK   YL+ LP+ S+IIPFH E W+ L+RT+ S+I R P  LI E+ILVDD S +  L+  LE ++   +   +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDEF EY+Y RRP  R+    +++ Q  +R++L CK+F WFM  VA+D+   YP +EP P   GEI+    N   +C+D K   +G  + L  C+    +     EQ F   W+ +I+P +    R  C D+  H     V L+ CHG +GNQ + Y+ + + +    S  C++ +PA K I +  C+     Q+WI+  +NMT L+K 
Sbjct:   68 DWHDYESIQKEAMRSGKGEHGKPY--PLTEEDHDDSAYRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHLKDKLEEYMAR-FSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAAN---LCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISH--NSPVTLYDCHGMKGNQLWGYR-KDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKF 595          

Query:  598 LQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKL 1824
            L+  LE ++   +   +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDEF EY+Y RRP  R+    +++ Q  +R++L CK+F WFM  VA+D+   YP +EP P   GEI+    N   +C+D K   +G  + L  C+    +     EQ F   W+ +I+P +    R  C D+  H     V L+ CHG +GNQ + Y+ + + +    S  C++ +PA K I +  C+     Q+WI+  +NMT L+K 
Sbjct:    3 LKDKLEEYMAR-FSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAAN---LCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISH--NSPVTLYDCHGMKGNQLWGYR-KDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKF 411          

Query:  274 RRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMT 1809
            + GPGE G  V IPK ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ SV+I FH E WS L+RTV SVI R+P  L+ EVILVDDAS + FL+ TLE ++K      K++R   R GLIR R+ GA  + G V+ FLD+H E  + WL PLL  I ++ KTV CP IDVI+ DTFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G+ I++N +R+AEVWMDEFK++ Y+  P +   D  +++ +  +RE L CK FSW+++ +  D       I       GEI+    N    C+D   R     VG+  C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  RGNQ ++Y  E   +  VNS  CL+ +P+ +   + T  +    +   W   NMT
Sbjct:   54 QEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFP-GGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPD-----SQIPRRYYSLGEIRNVETNQ---CLDNMGRKENEKVGIFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--NGPVIMLKCHHMRGNQLWEYDAERLTLRHVNSNQCLD-EPSEEDKMVPTMQDCSGSRSQQWLLRNMT 553          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQ--RIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHY--PIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYR-KYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASK-HIALQTCNETITDQKWIWTSVN 1803
            + W +    E+E +R GPGE G  V++P+ +E E++   +YK NGY+ Y SD IS+ RS++DIRH  CK + Y   LP+VSVI PFH+EH S L+R+V SVI R+P  L+KE+ILVDD S KP L++ LE FLK++    I KVLRT  R+GLIR R LGA++A G++LIFLD+HSEAN NWLPPLL+PIA++Y+TV CPF+DVI+ +T+E   QDEGARG FDW F+YKR+P  K D   P  PF SPVMAGG FAIS KWFWELGGYDEGLDIWGGEQYE+SFK+WQC G+M+D PCSR+ H+YR KY+PF N   G+F+SRN+KRVAEVWMD++KE LY  RP + N D  +L     IREKL CK+F WFMKE+AFD    YP +EP     GEI+    N    CID +F++     GL  C S +   GGEQ+  L+   +I+PK R +C D S  +    V+LF CH  +GNQ FKY++  +QI    SG CL  D   K  + ++ C+ +   QKW W +V+
Sbjct:  161 IKWEDEAAYEKEKRREGPGEWGKPVKLPEDKEVEKEALSLYKANGYNAYISDMISLNRSIKDIRHKECKNMMYSAKLPTVSVIFPFHEEHNSTLLRSVYSVINRSPPELLKEIILVDDFSEKPALRQPLEDFLKKNKIDHIVKVLRTKKREGLIRGRQLGAQDATGEILIFLDAHSEANYNWLPPLLDPIAEDYRTVVCPFVDVIDCETYEVRPQDEGARGSFDWAFNYKRLPLTKKDRESPTKPFNSPVMAGGYFAISAKWFWELGGYDEGLDIWGGEQYELSFKVWQCHGRMVDAPCSRVAHIYRCKYAPFKNAGMGDFVSRNYKRVAEVWMDDYKETLYKHRPGVGNADAGDLKLMKGIREKLQCKSFDWFMKEIAFDQDKYYPAVEPKASAEGEIRNVGTN---FCIDTQFKEQNQRFGLRKCTSDDKDGGGEQDLRLTRWHDIRPKGRKICFDCSTSVDKAPVILFDCHSMKGNQLFKYRVAQKQIYHPISGQCLTADENGKGFLHMKKCDSSSDLQKWAWQTVD 687          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQ--RIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHY--PIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYR-KYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASK-HIALQTCNETITDQKWIWTSVN 1803
            + W +    E+E +R GPGE G  V++P+ +E E++   +YK NGY+ Y SD IS+ RS++DIRH  CK + Y   LP+VSVI PFH+EH S L+R+V SVI R+P  L+KE+ILVDD S KP L++ LE FLK++    I KVLRT  R+GLIR R LGA++A G++LIFLD+HSEAN NWLPPLL+PIA++Y+TV CPF+DVI+ +T+E   QDEGARG FDW F+YKR+P  K D   P  PF SPVMAGG FAIS KWFWELGGYDEGLDIWGGEQYE+SFK+WQC G+M+D PCSR+ H+YR KY+PF N   G+F+SRN+KRVAEVWMD++KE LY  RP + N D  +L     IREKL CK+F WFMKE+AFD    YP +EP     GEI+    N    CID +F++     GL  C S +   GGEQ+  L+   +I+PK R +C D S  +    V+LF CH  +GNQ FKY++  +QI    SG CL  D   K  + ++ C+ +   QKW W +V+
Sbjct:   80 IKWEDEAAYEKEKRREGPGEWGKPVKLPEDKEVEKEALSLYKANGYNAYISDMISLNRSIKDIRHKECKNMMYSAKLPTVSVIFPFHEEHNSTLLRSVYSVINRSPPELLKEIILVDDFSEKPALRQPLEDFLKKNKIDHIVKVLRTKKREGLIRGRQLGAQDATGEILIFLDAHSEANYNWLPPLLDPIAEDYRTVVCPFVDVIDCETYEVRPQDEGARGSFDWAFNYKRLPLTKKDRESPTKPFNSPVMAGGYFAISAKWFWELGGYDEGLDIWGGEQYELSFKVWQCHGRMVDAPCSRVAHIYRCKYAPFKNAGMGDFVSRNYKRVAEVWMDDYKETLYKHRPGVGNADAGDLKLMKGIREKLQCKSFDWFMKEIAFDQDKYYPAVEPKASAEGEIRNVGTN---FCIDTQFKEQNQRFGLRKCTSDDKDGGGEQDLRLTRWHDIRPKGRKICFDCSTSVDKAPVILFDCHSMKGNQLFKYRVAQKQIYHPISGQCLTADENGKGFLHMKKCDSSSDLQKWAWQTVD 606          

Query:   70 FACFAALVYLIVNSVYFRNPNSIENSSNVATTQSVE----LSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIY-KENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYL----SQDEGARGIFDWNFDYKRIP---RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIW 1791
            + C   LV  +   VY    NS+ +  + +  Q  +    L+ +EL      +      +  NY   E E+    PGE G  V +   E     R   KE G++ Y SD IS+ R++ DIR   CK   Y + LP+VSV++ FH E W+PL+RTV SV+ R+P  LI++V++VDD S KP L++ L+ ++        V+RT  R+GLI  R +GAK + G+V++FLD+H E N NWLPPLL PI +N K +T P ID I+ +++EY     S +    GIF+W   YK      R  +   H + PF SP  AGGLFAI+R WF ELG YDEGL IWGGEQYE+SFK+WQCGG ++ +PCS +GHVYR + P  F   +    IS N  RV + WMD++ +Y   R P   N +P +++ Q A+R+KL CK+F W+M+ VA+D++ +YP++ PN V  GE +  NP     C+D      G  +G + C    H  GG Q   L+ +G++     + C+ ++    G  +    C  G  N F+ Y  +++QI+      C+    +   + LQTC E    QK++W
Sbjct:   24 YICLGVLV--LFGFVYNSKGNSMSSIKSDSAAQQFDDLDDLTNKELPGGPDPNTIFRGSELGNYEPKEPEIPSNQPGEHGKPVPVTDEEGMAAGRAAEKEFGFNTYVSDMISMNRTIPDIRPEECKHWDYPEKLPTVSVVVVFHNEGWTPLLRTVHSVLLRSPPELIEQVVMVDDDSDKPHLKEKLDKYVTRFNGKVIVVRTEQREGLINARSIGAKHSTGEVVLFLDAHCEVNTNWLPPLLAPIKRNRKVMTVPVIDGIDSNSWEYRSVYGSPNAHHSGIFEWGLLYKETQITERETAHRKHNSQPFRSPTHAGGLFAINRLWFKELGYYDEGLQIWGGEQYELSFKIWQCGGGIVFVPCSHVGHVYRSHMPYSFGKFSGKPVISINMMRVVKTWMDDYSKYYLTREPQATNVNPGDISAQLALRDKLQCKSFKWYMENVAYDVLKSYPMLPPNDVW-GEAR--NP-ATGKCLDRMGGIPG-PMGATGC----HGYGGNQLIRLNVQGQM--AQGEWCLTAN----GIRIQANHCVKGTVNGFWSYDRKTKQIIHSQKRQCITVSESGSEVTLQTCTEDNERQKFVW 594          

Query:  244 NYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIY-KENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYL----SQDEGARGIFDWNFDYKRIP---RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIW 1791
            NY   E E+    PGE G  V +   E     R   KE G++ Y SD IS+ R++ DIR   CK   Y + LP+VSV++ FH E W+PL+RTV SV+ R+P  LI++V++VDD S KP L++ L+ ++        V+RT  R+GLI  R +GAK + G+V++FLD+H E N NWLPPLL PI +N K +T P ID I+ +++EY     S +    GIF+W   YK      R  +   H + PF SP  AGGLFAI+R WF ELG YDEGL IWGGEQYE+SFK+WQCGG ++ +PCS +GHVYR + P  F   +    IS N  RV + WMD++ +Y   R P   N +P +++ Q A+R+KL CK+F W+M+ VA+D++ +YP++ PN V  GE +  NP     C+D      G  +G + C    H  GG Q   L+ +G++     + C+ ++    G  +    C  G  N F+ Y  +++QI+      C+    +   + LQTC E    QK++W
Sbjct:   41 NYEPKEPEIPSNQPGEHGKPVPVTDEEGMAAGRAAEKEFGFNTYVSDMISMNRTIPDIRPEECKHWDYPEKLPTVSVVVVFHNEGWTPLLRTVHSVLLRSPPELIEQVVMVDDDSDKPHLKEKLDKYVTRFNGKVIVVRTEQREGLINARSIGAKHSTGEVVLFLDAHCEVNTNWLPPLLAPIKRNRKVMTVPVIDGIDSNSWEYRSVYGSPNAHHSGIFEWGLLYKETQITERETAHRKHNSQPFRSPTHAGGLFAINRLWFKELGYYDEGLQIWGGEQYELSFKIWQCGGGIVFVPCSHVGHVYRSHMPYSFGKFSGKPVISINMMRVVKTWMDDYSKYYLTREPQATNVNPGDISAQLALRDKLQCKSFKWYMENVAYDVLKSYPMLPPNDVW-GEAR--NP-ATGKCLDRMGGIPG-PMGATGC----HGYGGNQLIRLNVQGQM--AQGEWCLTAN----GIRIQANHCVKGTVNGFWSYDRKTKQIIHSQKRQCITVSESGSEVTLQTCTEDNERQKFVW 551          

Query:  286 GEQGSGVRIPKAE--EEEQQRIYK---ENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDE--GARGIFDW--NFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNE--DPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVN 1803
            GE G  V + K +   EE+ +  K    N ++ YASD IS+ R+L       CKT KY ++LP  SVII FH E WS L+RTV SV+ R P  L++EV+LVDD S     ++ LE ++ +     K+LR   R+GLIR R+ GA  A G+VL +LDSH E    W+ PLL+ I ++  TV CP IDVI+ +TFEY        + G FDW   F++  IP R + + + P DP  SP MAGGLF+I +K+F +LG YD G DIWGGE  E+SFK+W CGG +  +PCS +GHV+RK SP+      N + RN  R+AEVW+D++K Y Y R   I N+  D  +++++  +RE L CK+F W++  +  +L      +    V  GE++ +   N   CID+K    G  VG+  C    H +GG Q ++LS  GEI+  +   C+D +    G  V++F CHG +GNQ ++Y  ++ ++    S  CL        + +  C      Q W +   N
Sbjct:  113 GELGKAVVVDKTKLSTEEKAKYDKGMLNNAFNQYASDMISVHRTLPTNIDAECKTEKYNENLPRTSVIICFHNEAWSVLLRTVHSVLERTPDHLLEEVVLVDDFSDMDHTKRPLEEYMSQFGGKVKILRMEKREGLIRARLRGAAVATGEVLTYLDSHCECMEGWMEPLLDRIKRDPTTVVCPVIDVIDDNTFEYHHSKAYFTSVGGFDWGLQFNWHSIPERDRKNRTRPIDPVRSPTMAGGLFSIDKKYFEKLGTYDPGFDIWGGENLELSFKIWMCGGTLEIVPCSHVGHVFRKRSPYKWRTGVNVLKRNSIRLAEVWLDDYKTYYYER---INNQLGDFGDISSRKKLREDLGCKSFKWYLDNIYPEL-----FVPGESVAKGEMRNAGGKNRQ-CIDYK-PSGGKTVGMYQC----HNQGGNQYWMLSKDGEIRRDES--CVDYA----GSDVMVFPCHGMKGNQEWRYNHDTGRLQHAVSQKCLGMTKDGAKLEMVACQYDDPYQHWKFKEYN 610          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIP-KAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVY---RKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTI-RNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSG-FCLEGDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            DWH+YT +E++ KR G GE G    +  +++ + ++R+  ENG++   SD IS+ RS+ DIRHP C+  +Y+  LP+VSVII F+ E+ S L+R+V S+I R+P  L+KE+ILVDD S + +L K LE ++ EH+   +V+R   R GLI  R  GA+ A  +VLIFLDSH EAN NWLPPLLEPIA N +T  CPFIDVI++  F Y +QDEGARG FDW F YKR+P    D  HPADPF+SP+MAGGLFAISR++FWELGGYDEGLDIWGGEQYE+SFK+W CGG+M D PCSRIGH+Y   R + P P   KG+++ +N+KRVAEVWMDE+K YLY     +  + DP +LT Q AIR KL+CK+F WFM+EVAFDL+  YP ++P     G   L N  N ++C+D   R     +G+  C          Q + LSWK +++ + +  C+D         V L+ CH   GNQ++ Y    +Q+     G  CLE  P S+ +    C+     Q+W + S N T L
Sbjct:  127 DWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPR--KGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMG--ALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTAL 655          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIP-KAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVY---RKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTI-RNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSG-FCLEGDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            DWH+YT +E++ KR G GE G    +  +++ + ++R+  ENG++   SD IS+ RS+ DIRHP C+  +Y+  LP+VSVII F+ E+ S L+R+V S+I R+P  L+KE+ILVDD S + +L K LE ++ EH+   +V+R   R GLI  R  GA+ A  +VLIFLDSH EAN NWLPPLLEPIA N +T  CPFIDVI++  F Y +QDEGARG FDW F YKR+P    D  HPADPF+SP+MAGGLFAISR++FWELGGYDEGLDIWGGEQYE+SFK+W CGG+M D PCSRIGH+Y   R + P P   KG+++ +N+KRVAEVWMDE+K YLY     +  + DP +LT Q AIR KL+CK+F WFM+EVAFDL+  YP ++P     G   L N  N ++C+D   R     +G+  C          Q + LSWK +++ + +  C+D         V L+ CH   GNQ++ Y    +Q+     G  CLE  P S+ +    C+     Q+W + S N T L
Sbjct:  127 DWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPR--KGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMG--ALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTAL 655          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIP-KAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVY---RKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTI-RNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSG-FCLEGDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            DWH+YT +E++ KR G GE G    +  +++ + ++R+  ENG++   SD IS+ RS+ DIRHP C+  +Y+  LP+VSVII F+ E+ S L+R+V S+I R+P  L+KE+ILVDD S + +L K LE ++ EH+   +V+R   R GLI  R  GA+ A  +VLIFLDSH EAN NWLPPLLEPIA N +T  CPFIDVI++  F Y +QDEGARG FDW F YKR+P    D  HPADPF+SP+MAGGLFAISR++FWELGGYDEGLDIWGGEQYE+SFK+W CGG+M D PCSRIGH+Y   R + P P   KG+++ +N+KRVAEVWMDE+K YLY     +  + DP +LT Q AIR KL+CK+F WFM+EVAFDL+  YP ++P     G   L N  N ++C+D   R     +G+  C          Q + LSWK +++ + +  C+D         V L+ CH   GNQ++ Y    +Q+     G  CLE  P S+ +    C+     Q+W + S N T L
Sbjct:  127 DWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPR--KGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMG--ALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTAL 655          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEE-QQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYP-IAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQD-EGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKG-NFISRNFKRVAEVWMDEFKEYLYLRRP-TIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRD-MCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILF-VNSGFCLEG--DPASKHIALQTCNETITDQKWIWTSVNMTELKKLHD 1830
            DWH+Y  +E + KR G GE G  V+I   +E++ ++  Y+ NG++G  SD+IS+ RS+ D+R  ACKT KYL  LP++SVI  F  EH++ L+R++ SVI R P  L+K+++LVDD S    L++ L+ ++++H+P +  ++R   RQGLI  R+ GAK A+G V++F DSH E N NWLPPL+EPIA N K  TCP +D I+++ F Y S + +GARG FDW   YK++P    D    + P+ SPVM GGLFAI+  +FW+LGGYD+ LDIWGGEQYE+SFK+W CGG +LD+PCSR+ H++R       N +G NF+++N KRVAEVWMDE+K+Y+Y R P T  N D  +LT Q  +RE+L CK+F WFM EVA D +  +P +EP    +G I+  N  N   C+D   + +   VG+  C          Q + LS   +++ K  D +C+D  +  P  +V ++ CH   GNQF+ Y  ++Q+++   N+  CLEG  +     +   +C      Q+W +  VN T L   +D
Sbjct:  103 DWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQ--NVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEFGFVNHTMLDTFYD 641          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEE-QQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYP-IAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQD-EGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKG-NFISRNFKRVAEVWMDEFKEYLYLRRP-TIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRD-MCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILF-VNSGFCLEG--DPASKHIALQTCNETITDQKWIWTSVNMTELKKLHD 1830
            DWH+Y  +E + KR G GE G  V+I   +E++ ++  Y+ NG++G  SD+IS+ RS+ D+R  ACKT KYL  LP++SVI  F  EH++ L+R++ SVI R P  L+K+++LVDD S    L++ L+ ++++H+P +  ++R   RQGLI  R+ GAK A+G V++F DSH E N NWLPPL+EPIA N K  TCP +D I+++ F Y S + +GARG FDW   YK++P    D    + P+ SPVM GGLFAI+  +FW+LGGYD+ LDIWGGEQYE+SFK+W CGG +LD+PCSR+ H++R       N +G NF+++N KRVAEVWMDE+K+Y+Y R P T  N D  +LT Q  +RE+L CK+F WFM EVA D +  +P +EP    +G I+  N  N   C+D   + +   VG+  C          Q + LS   +++ K  D +C+D  +  P  +V ++ CH   GNQF+ Y  ++Q+++   N+  CLEG  +     +   +C      Q+W +  VN T L   +D
Sbjct:  103 DWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQ--NVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEFGFVNHTMLDTFYD 641          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIPRFKSDES-HPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVS-VCIDFKFRDSGYVVGLSPCLSVNHKEGG------EQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            DWH+Y  I ++ +R G GE G     P  E+E    +YKENG++ Y S+ I++ RSL DIRHP CK   YL++LP+ S+IIPFH E WS L+RT+ S+  R P  LI E+ILVDD S +  L+  L  ++   +P  +++RT  R+GLIRTR+LGA  A G+VL FLDSH EAN+NWLPPLL+ IA+N KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP     +   P+DP++SPVMAGGLFA++R+WFWELGGYD GL+IWGGEQ+EISFK+W CGG M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDE+ EY+Y RRP  R+    +LT Q  +R+ L CK+F W+M  VA+DL   YP +EP P   GEI+    N  S +C+D K   +G  + L  CL    KEG       EQ F   W+ +I+P D    R  C D+        + L+ CHG +GNQ + Y+ +      V+SG C++  P  K I +  C+     Q+WI+  VN T L K +
Sbjct:   67 DWHDYESIRKDGQRVGKGEHGKPY--PLVEDECDDSVYKENGFNIYVSNNIALDRSLPDIRHPNCKQKLYLENLPNTSIIIPFHNEGWSSLLRTLHSISNRTPDHLIAEIILVDDYSDREHLKAHLAEYMSR-FPKVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEANINWLPPLLDQIAQNPKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQGPDPSDPYQSPVMAGGLFAVNRQWFWELGGYDTGLEIWGGEQFEISFKVWMCGGSMYDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEYTEYIYQRRPEYRHLSTGDLTAQKELRKHLKCKDFKWYMNTVAWDLPKYYPPVEPLPAAWGEIR----NAASGLCVDSKHGSTGTELRLDNCL----KEGAERTWAHEQIFTFGWREDIRPGDPLHTRKFCFDAISQ--NSPITLYDCHGMKGNQHWSYRKDKSLYHLVSSG-CMDCSPNDKRIFMNKCDPKSETQQWIFQKVNATVLDKFN 595          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIPRFKSDES-HPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVS-VCIDFKFRDSGYVVGLSPCLSVNHKEGG------EQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            DWH+Y  I ++ +R G GE G     P  E+E    +YKENG++ Y S+ I++ RSL DIRHP CK   YL++LP+ S+IIPFH E WS L+RT+ S+  R P  LI E+ILVDD S +  L+  L  ++   +P  +++RT  R+GLIRTR+LGA  A G+VL FLDSH EAN+NWLPPLL+ IA+N KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP     +   P+DP++SPVMAGGLFA++R+WFWELGGYD GL+IWGGEQ+EISFK+W CGG M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDE+ EY+Y RRP  R+    +LT Q  +R+ L CK+F W+M  VA+DL   YP +EP P   GEI+    N  S +C+D K   +G  + L  CL    KEG       EQ F   W+ +I+P D    R  C D+        + L+ CHG +GNQ + Y+ +      V+SG C++  P  K I +  C+     Q+WI+  VN T L K +
Sbjct:   67 DWHDYESIRKDGQRVGKGEHGKPY--PLVEDECDDSVYKENGFNIYVSNNIALDRSLPDIRHPNCKQKLYLENLPNTSIIIPFHNEGWSSLLRTLHSISNRTPDHLIAEIILVDDYSDREHLKAHLAEYMSR-FPKVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEANINWLPPLLDQIAQNPKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQGPDPSDPYQSPVMAGGLFAVNRQWFWELGGYDTGLEIWGGEQFEISFKVWMCGGSMYDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEYTEYIYQRRPEYRHLSTGDLTAQKELRKHLKCKDFKWYMNTVAWDLPKYYPPVEPLPAAWGEIR----NAASGLCVDSKHGSTGTELRLDNCL----KEGAERTWAHEQIFTFGWREDIRPGDPLHTRKFCFDAISQ--NSPITLYDCHGMKGNQHWSYRKDKSLYHLVSSG-CMDCSPNDKRIFMNKCDPKSETQQWIFQKVNATVLDKFN 595          

Query:  637 PIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGE--QNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            P  ++LRT  R+GLIRTR+LGA  A G V+ FLDSH EANVNWLPPLL+ IA+N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  +  P++PF+SPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+     G  ++RN KRVAEVWMDE+ E+LY RRP  R+    +++ Q  +R +LHC++F WFM+EVA+DL  +YP +EP     GE++        +C++ K   SG  + L PCL    +      Q F   W+ +I+  D    + +C D+  H     V L+ CHG +GNQ + Y+ + + +    S  C+  D A K + + +C+ + + Q+W++ + N + L
Sbjct:    5 PKVRILRTQKREGLIRTRLLGAAAARGQVITFLDSHCEANVNWLPPLLDRIAQNRKTIVCPMIDVIDHDNFGYETQAGDAMRGAFDWEMYYKRIPIPAQLAKPDPSEPFDSPVMAGGLFAVDRKWFWELGGYDTGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPY-KVPGGVSLARNLKRVAEVWMDEYAEFLYQRRPEYRHLSSGDVSQQKELRSRLHCRSFRWFMEEVAWDLPKHYPPVEPPAAAWGELRNV---GTGLCVESKHFSSGSPIRLEPCLRSRGEPSWSHGQVFTFGWRQDIRVGDPLHTKKVCFDAVSH--NSPVTLYDCHGMKGNQLWAYR-KDRSLFHPISNSCVSADAAQKRLLMSSCDASSSSQQWVFQNTNSSVL 398          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMT 1809
             PGE G  V IPK E+++ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ S++I FH E WS L+RTV S I R+P  L+ E++LVDDAS + FL++ LE ++       ++LR   R GLIR R+ GA    G V+ FLD+H E    WL PL+  I ++ + V CP IDVI+ +TFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK++ Y+  P +   D  +++++ A+RE L CK FSW+++ V  D       I       GEI+    N    C+D   R     VG   C    H  GG Q F  +   EI+    D+C+D+S     G V++ KCH  +GNQ F+Y  E   +L VNS  CL+  P+ +   + T  +    +   W   NMT
Sbjct:   56 APGEMGKAVVIPKEEQDKMKELFKINQFNLMASDMIALNRSLPDVRLDGCKTKTYPDDLPNTSIVIVFHNEAWSTLLRTVHSAINRSPRQLLYEILLVDDASERDFLKEKLEDYVATLEVPVRILRMEQRTGLIRARLRGAAATRGQVITFLDAHCECTTGWLEPLMARIKEDRRAVVCPIIDVISDETFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRTYFEEIGTYDSGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYSFPGGT-GQVINKNNRRLAEVWMDEFKDFFYIISPGVVRVDYGDVSSRKALRESLKCKPFSWYLENVYPD-----SQIPRRYYSLGEIRNVETNQ---CVDNMGRKENEKVGFFNC----HGMGGNQVFSYTADKEIRTD--DLCLDASRL--NGPVVMLKCHHMKGNQMFEYDAERLTLLHVNSNQCLDM-PSEEDKMVPTLKDCSGRRSQQWILRNMT 553          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLE--GDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            GPGE G  V I K ++E+ + ++K N ++  AS+ I++ RSL D+R   CKT  Y   LP  SV+I FH E W+ L+RTV SVI R+P  L++E++LVDDAS + FL++ LE ++++     +V+R   R GLIR R+ GA  + G V+ FLD+H E    WL PLL  I  + KTV CP IDVI+ DTFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  EISF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK + Y+  P +   D  +++ + ++R++L CK FSW+++ V  D       I  +    GEI+    N    C+D   R     VG+  C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ ++Y      ++ VNS  CL+   +  S+  +++ C+   + Q+W+  +V + E+
Sbjct:   55 GPGEMGKPVVIAKDQQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDDLPRTSVVIVFHNEAWTTLLRTVHSVIDRSPRHLLEEIVLVDDASERDFLKRQLEHYVRKLEVPVRVVRMEQRSGLIRARLKGASISTGQVITFLDAHCECTTGWLEPLLSRIKLDKKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGT-GQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISTRTSLRQRLQCKPFSWYLENVYPD-----SQIPRHYYSLGEIRNVETNQ---CLDNMARKENEKVGIFNC----HGMGGNQVFSYTANKEIRTD--DLCLDVSKL--NGPVMMLKCHHLKGNQLWEYDPVKLSLVHVNSNQCLDKASEDDSQVPSVRDCSGARS-QQWLLRNVTLPEI 556          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLHDFN 1836
            DWH+Y  I++E  R G GE G     P  EEE+   +Y+ENG++ + S+KI++ RSL DIRHP CK   YL+ LP+ S+IIPFH E W+ L+RT+ SVI R P  LI+E+ILVDD S +  L++ LE ++  +YP  +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P++PFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYE+SFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDE+ EY+Y RRP  R+    ++++Q  +R+ L CK+F W+M EVA+D+   YP +EP P   GEI+    N   +CID K   +G  + L  C+    +     EQ F   W+ +I+P +    R  C DS  H     V L+ CHG +GNQ + Y+ + + +    +  C++ +PA K + +  C+     Q+WI+  VNMT L+K + +N
Sbjct:   67 DWHDYESIQKEALRSGKGEHGKPY--PLTEEEQDDTVYRENGFNIFVSNKIALARSLPDIRHPNCKHKLYLERLPNTSIIIPFHNEGWTSLLRTIHSVINRTPDSLIEEMILVDDFSDREHLREKLEEYMA-YYPKVRIVRTKKREGLIRTRLLGASMAKGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRTDPSEPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYELSFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPTGTSLARNLKRVAETWMDEYAEYIYQRRPEYRHLSTGDISSQKELRKHLKCKDFKWYMSEVAWDVPKFYPPVEPPPASWGEIRNVASN---LCIDSKHGATGTELRLDTCVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDSISH--SSPVTLYDCHGMKGNQQWSYR-KDKTLFHPVTNSCIDCNPAEKKLFMNRCDPLSETQQWIFEHVNMTILQKFNIYN 598          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKDRDMCMDSS-DHIPGGS-VLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            DWHNY QI +E ++ G GEQG    +  A+  +Q   Y+ENG++ + SDKIS+ RSL DIRH  CK   Y   LP+ SVIIPFH E WS L+RTV SV+ R+P  LI E++LVDD S K  L+  LE ++  ++P  K++RT  R+GLIRTR+LGA  A G+VL FLDSH EANVNWLPPLL+P+ +NYKTV CP IDVI+ D F Y++Q  +  RG FDW   YKRIP   +  +  P+DPF+SPVMAGGLFAI+R+WFW+LGGYD GL+IWGGEQYEISFK+W CGG+M+D PCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R KL C++F WFM E+A+DL   YP +E  P   GEI+      + +C+  K   SG  + L  C    + +  G  Q F L W+ +I+P      M S  D +   S V LF CHG +GNQ +KY+ + + +    S  C++ +     I +  CN +   Q+W +  +N T L+  +
Sbjct:   70 DWHNYEQIRKESEQIGNGEQGKPFPMTDADHVDQA--YRENGFNIFVSDKISLNRSLPDIRHSNCKNKFYFSKLPNTSVIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDYSDKAHLKSRLEKYMA-NFPKVKIVRTKKREGLIRTRMLGATVASGEVLTFLDSHCEANVNWLPPLLDPLVQNYKTVVCPMIDVIDSDNFGYVTQAGDAMRGAFDWEMFYKRIPIPPELQKGDPSDPFDSPVMAGGLFAINREWFWQLGGYDPGLEIWGGEQYEISFKVWMCGGRMVDSPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPDYRHLSVGDVAAQKELRRKLQCRDFKWFMNEIAWDLPKYYPPVELPPAAWGEIRNV---RMDMCVGVKHVTSGTEIRLEACNKGRNSDTWGARQVFTLGWREDIRPGIPQHTMKSCFDAVSQTSPVTLFDCHGMKGNQLWKYRRD-KTVYHPTSNSCMDCNEGEYKIFMNKCNPSSPTQQWTFEHINSTILEAFN 598          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKDRDMCMDSS-DHIPGGS-VLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            DWHNY QI +E ++ G GEQG    +  A+  +Q   Y+ENG++ + SDKIS+ RSL DIRH  CK   Y   LP+ SVIIPFH E WS L+RTV SV+ R+P  LI E++LVDD S K  L+  LE ++  ++P  K++RT  R+GLIRTR+LGA  A G+VL FLDSH EANVNWLPPLL+P+ +NYKTV CP IDVI+ D F Y++Q  +  RG FDW   YKRIP   +  +  P+DPF+SPVMAGGLFAI+R+WFW+LGGYD GL+IWGGEQYEISFK+W CGG+M+D PCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R KL C++F WFM E+A+DL   YP +E  P   GEI+      + +C+  K   SG  + L  C    + +  G  Q F L W+ +I+P      M S  D +   S V LF CHG +GNQ +KY+ + + +    S  C++ +     I +  CN +   Q+W +  +N T L+  +
Sbjct:   70 DWHNYEQIRKESEQIGNGEQGKPFPMTDADHVDQA--YRENGFNIFVSDKISLNRSLPDIRHSNCKNKFYFSKLPNTSVIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDYSDKAHLKSRLEKYMA-NFPKVKIVRTKKREGLIRTRMLGATVASGEVLTFLDSHCEANVNWLPPLLDPLVQNYKTVVCPMIDVIDSDNFGYVTQAGDAMRGAFDWEMFYKRIPIPPELQKGDPSDPFDSPVMAGGLFAINREWFWQLGGYDPGLEIWGGEQYEISFKVWMCGGRMVDSPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPDYRHLSVGDVAAQKELRRKLQCRDFKWFMNEIAWDLPKYYPPVELPPAAWGEIRNV---RMDMCVGVKHVTSGTEIRLEACNKGRNSDTWGARQVFTLGWREDIRPGIPQHTMKSCFDAVSQTSPVTLFDCHGMKGNQLWKYRRD-KTVYHPTSNSCMDCNEGEYKIFMNKCNPSSPTQQWTFEHINSTILEAFN 598          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLHDFN 1836
            DWH+Y  I++E  R G GE G     P  EEE+   +Y+ENG++ + S+KI++ RSL DIRHP CK   YL+ LP+ S+IIPFH E W+ L+RT+ SVI R P  LI+E+ILVDD S +  L++ LE ++  +YP  +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P++PFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYE+SFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDE+ EY+Y RRP  R+    ++++Q  +R+ L CK+F W+M EVA+D+   YP +EP P   GE+K++                        CL           F   W+ +I+P +    R  C DS  H     V L+ CHG +GNQ + Y+ + + +    +  C++ +PA K + +  C+     Q+WI+  VNMT L+K + +N
Sbjct:   67 DWHDYESIQKEALRSGKGEHGKPY--PLTEEEQDDTVYRENGFNIFVSNKIALARSLPDIRHPNCKHKLYLERLPNTSIIIPFHNEGWTSLLRTIHSVINRTPDSLIEEMILVDDFSDREHLREKLEEYMA-YYPKVRIVRTKKREGLIRTRLLGASMAKGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRTDPSEPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYELSFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPTGTSLARNLKRVAETWMDEYAEYIYQRRPEYRHLSTGDISSQKELRKHLKCKDFKWYMSEVAWDVPKFYPPVEPPPASWGEVKIN------------------------CL-----------FTFGWREDIRPGEPLHTRKFCFDSISH--SSPVTLYDCHGMKGNQQWSYR-KDKTLFHPVTNSCIDCNPAEKKLFMNRCDPLSETQQWIFEHVNMTILQKFNIYN 564          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYK 1671
            DWH+Y  I++E  R G GE G     P  EEE+   +Y+ENG++ + S+KI++ RSL DIRHP CK   YL+ LP+ S+IIPFH E W+ L+RT+ SVI R P  LI+E+ILVDD S +  L++ LE ++  +YP  +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P++PFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYE+SFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDE+ EY+Y RRP  R+    ++++Q  +R+ L CK+F W+M EVA+D+   YP +EP P   GE+K++                        CL           F   W+ +I+P +    R  C DS  H     V L+ CHG +GNQ + Y+
Sbjct:   67 DWHDYESIQKEALRSGKGEHGKPY--PLTEEEQDDTVYRENGFNIFVSNKIALARSLPDIRHPNCKHKLYLERLPNTSIIIPFHNEGWTSLLRTIHSVINRTPDSLIEEMILVDDFSDREHLREKLEEYMA-YYPKVRIVRTKKREGLIRTRLLGASMAKGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRTDPSEPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYELSFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPTGTSLARNLKRVAETWMDEYAEYIYQRRPEYRHLSTGDISSQKELRKHLKCKDFKWYMSEVAWDVPKFYPPVEPPPASWGEVKIN------------------------CL-----------FTFGWREDIRPGEPLHTRKFCFDSISH--SSPVTLYDCHGMKGNQQWSYR 510          

Query:  220 ESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEG--GEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            E  L DWHN   I  + +R G GEQG    +  AE  +Q   Y+ENG++ Y SDKIS+ RSL DIRHP C +  YL++LP+ S+IIPFH E WS L+RTV SV+ R+P  L+ E++LVDD S +  L+K LE ++   +P  ++LRT  R+GLIRTR+LGA  A GDV+ FLDSH EANVNWLPPLL+ IA+N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  ++ P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R  L+CK+F WFM ++A+DL   YP +EP     GEI+        +C D K    G  + L  C+    +      Q F  +W+ +I+P D    +  C D+  H     V L+ CH  +GNQ +KY+ + + +    SG C++   +   + + TCN +   Q+W++   N T L+  +
Sbjct:   68 EQRLKDWHNKEAIRRDAQRVGYGEQGKPYPMTDAERVDQA--YRENGFNIYVSDKISLNRSLPDIRHPNCNSKLYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMA-LFPSVRILRTKKREGLIRTRMLGASAATGDVVTFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVVAQKKLRVSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNV---GTGLCTDTKLGTLGSPLRLETCIRGRGEAAWNSMQVFTFTWREDIRPGDPQHTKKFCFDAVSHT--SPVTLYDCHSMKGNQLWKYR-KDKTLYHPVSGSCMDCSESDHRVFMNTCNPSSLTQQWLFEHTNSTVLENFN 601          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKK 1821
            DWH+Y  I+ +  R G GE G     P  EE+     Y+ENG++ + S+ I+++RSL DIRH  CK   YL+ LP+ S+IIPFH E W+ L+RT+ S+I R P  LI E+ILVDD S +  L+  LE ++   +   +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDEF EY+Y RRP  R+    +++ Q  +R++L CK+F WFM  VA+D+   YP +EP P   GEI+    N   +C+D K   +G  + L  C+    +     EQ F   W+ +I+P +    R  C+D+  H     V L+ CHG +GNQ + Y+ E + +    S  C++ +P+ K I +  C+     Q+WI+  +NMT L+K
Sbjct:   68 DWHDYESIQRDALRSGKGEHGKPY--PLTEEDRDDSAYRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPESLIAEIILVDDFSDREHLKDKLEDYMAR-FSKVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKRLKCKDFKWFMAAVAWDVPKYYPPVEPLPAAWGEIRSVAAN---LCVDSKHGATGTELRLDVCVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCLDAISH--SSPVTLYDCHGMKGNQLWGYR-EDRTLFHPVSNSCMDCNPSEKKIFMARCDPLSETQQWIFEHINMTVLEK 594          

Query:  598 LQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE--GGEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKK 1821
            L+  LE ++   +   +++RT  R+GLIRTR+LGA  A G+VL FLDSH E NVNWLPPLL  IA N+KT+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   + P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDEF EY+Y RRP  R+    +++ Q  +R++L CK+F WFM  VA+D+   YP +EP P   GEI+    N   +C+D K   +G  + L  C+    +     EQ F   W+ +I+P +    R  C+D+  H     V L+ CHG +GNQ + Y+ E + +    S  C++ +P+ K I +  C+     Q+WI+  +NMT L+K
Sbjct:    3 LKDKLEDYMAR-FSKVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKRLKCKDFKWFMAAVAWDVPKYYPPVEPLPAAWGEIRSVAAN---LCVDSKHGATGTELRLDVCVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCLDAISH--SSPVTLYDCHGMKGNQLWGYR-EDRTLFHPVSNSCMDCNPSEKKIFMARCDPLSETQQWIFEHINMTVLEK 410          

Query:  274 RRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMT 1809
            + GPGE G  V IPK ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ SV+I FH E WS L+RTV SVI R+P  L+ EVILVDDAS + FL+ TLE ++K      K++R   R GLIR R+ GA  + G V+ FLD+H E  + WL PLL  I ++ KTV CP IDVI+ DTFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G+ I++N +R+AEVWMDEFK++ Y+  P +   D  +++ +  +RE L CK FSW+++ +  D       I       GEI+    N    C+D   R     VG+  C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  RGNQ ++Y  E   +   NS  CL+ +P+ +   + T  +    +   W   NMT
Sbjct:   54 QEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKTLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGT-GHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPD-----SQIPRRYYSLGEIRNVETNQ---CLDNMGRKENEKVGIFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--SGPVIMLKCHHMRGNQLWEYDAERLTLRHANSNQCLD-EPSEEDKMVPTMQDCSGSRSQQWLLRNMT 553          

Query:  274 RRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMT 1809
            + GPGE G  V IPK ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ SV+I FH E WS L+RTV SVI R+P  L+ EVILVDDAS + FL+ TLE ++K      K++R   R GLIR R+ GA  + G V+ FLD+H E  + WL PLL  I ++ KTV CP IDVI+ DTFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G+ I++N +R+AEVWMDEFK++ Y+  P +   D  +++ +  +RE L CK FSW+++ +  D       I       GEI+    N    C+D   R     VG+  C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  RGNQ ++Y  E   +   NS  CL+ +P+ +   + T  +    +   W   NMT
Sbjct:   54 QEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKTLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGT-GHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPD-----SQIPRRYYSLGEIRNVETNQ---CLDNMGRKENEKVGIFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--SGPVIMLKCHHMRGNQLWEYDAERLTLRHANSNQCLD-EPSEEDKMVPTMQDCSGSRSQQWLLRNMT 553          

Query:   22 KITFAMTRFKLKN---FLKFACFAALVYLIVNSVYFRN--PNSIEN-------SSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQ--RIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHY--PIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYR-KYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASK-HIALQTCNETITDQKWIWTSVN 1803
            K++  ++R+  +     +++      +YLI + V   N  PN  E+         + A         +E L    ++     + W +    E+E +R GPGE G  V++P+ +E E++   +YK NGY+ Y SD IS+ RS++DIRH  CK + Y   LP+VSVI PFH+EH S L+R+V SVI R+P  L+KE+ILVDD S KP L++ LE FLK++    I KVLRT  R+GLIR R LGA++A G++LIFLD+HSEAN NWLPPLL+PIA++Y+TV CPF+DVI+ +T+E   QDEGARG FDW F+YKR+P  K D   P  PF SPVMAGG FAIS KWFWELGGYDEGLDIWGGEQYE+SFK+WQC G+M+D PCSR+ H+YR KY+PF N   G+F+SRN+KRVAEVWMD++KE LY  RP + N D  +L     IREKL CK+F WFMKE+AFD    YP +EP     GEI+    N    CID +F++     GL  C S +   GGEQ+  L+   +I+PK R +C D S  +    V+LF CH  +GNQ FKY++  +QI    SG CL  D   K  + ++ C+ +   QKW W +V+
Sbjct:   60 KLSMGLSRYLSRRHHWVIQYCGLLLFLYLIYSYVATSNDGPNLHEDIPVFQGQGKDRANPNPPAALGDEALDPFEKYRGHEKIKWEDEAAYEKEKRREGPGEWGKPVKLPEDKEVEKEALSLYKANGYNAYISDMISLNRSIKDIRHKECKNMMYSAKLPTVSVIFPFHEEHNSTLLRSVYSVINRSPPELLKEIILVDDFSEKPALRQPLEDFLKKNKIDHIVKVLRTKKREGLIRGRQLGAQDATGEILIFLDAHSEANYNWLPPLLDPIAEDYRTVVCPFVDVIDCETYEVRPQDEGARGSFDWAFNYKRLPLTKKDRESPTKPFNSPVMAGGYFAISAKWFWELGGYDEGLDIWGGEQYELSFKVWQCHGRMVDAPCSRVAHIYRCKYAPFKNAGMGDFVSRNYKRVAEVWMDDYKETLYKHRPGVGNADAGDLKLMKGIREKLQCKSFDWFMKEIAFDQDKYYPAVEPKASAEGEIRNVGTN---FCIDTQFKEQNQRFGLRKCTSDDKDGGGEQDLRLTRWHDIRPKGRKICFDCSTSVDKAPVILFDCHSMKGNQLFKYRVAQKQIYHPISGQCLTADENGKGFLHMKKCDSSSDLQKWAWQTVD 668          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIP--KAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHY--PIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYR-KYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASK-HIALQTCNETITDQKWIWTSVNMTEL 1815
            + W +    E++  R GPGE G  V++P  K  E+E   +YK NGY+ Y SD IS+ RS++DIRH  CK + Y   LP+VSVI PFH+EH S L+R+V SVI R+P  L+KE+ILVDD S KP L++ LE FLK++    I K+LRT  R+GLIR R LGA+EA G++LIFLD+HSE N NWLPPLL+PIA +Y+TV CPF+DVI+ +T+E   QDEGARG FDW F+YKR+P  K D  +P  PF+SPVMAGG FAIS KWFWELGGYDEGLDIWGGEQYE+SFK+WQC GKM+D PCSR+ H+YR KY+PF N   G+F+SRN+KRVAEVWMDE+KE LY  RP I N D  +L     IREKL CK+F WFMKE+AFD    YP IEP     GEI+    N   +CID +F++     GL  C S +   GGEQ+  L+   +I+PK R +C D S  +    ++LF CH  +GNQ FKY++  +QI    SG CL  D   K  + ++ C+ +   Q+W W +++   L
Sbjct:   87 IKWEDEVAYEKDKAREGPGEWGKPVKLPDDKETEKEALSLYKANGYNAYISDMISLNRSIKDIRHKECKKMTYSAKLPTVSVIFPFHEEHNSTLLRSVYSVINRSPPELLKEIILVDDFSEKPALRQPLEDFLKKNKIDHIVKILRTKKREGLIRGRQLGAQEATGEILIFLDAHSECNYNWLPPLLDPIADDYRTVVCPFVDVIDCETYEIRPQDEGARGSFDWAFNYKRLPLTKKDRENPTKPFDSPVMAGGYFAISAKWFWELGGYDEGLDIWGGEQYELSFKVWQCHGKMVDAPCSRVAHIYRCKYAPFKNAGMGDFVSRNYKRVAEVWMDEYKETLYKHRPGIGNADAGDLKLMKGIREKLQCKSFDWFMKEIAFDQDKYYPAIEPKASAEGEIRHVASN---LCIDTQFKEQNQRFGLRKCASEDKDGGGEQDLRLTRWHDIRPKGRKICFDVSTSVDKAPIILFDCHSMKGNQLFKYRMPQKQIYHPVSGQCLTADENGKGFLHMKKCDSSSKLQQWAWQTIDQELL 617          

Query:  220 ESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEG--GEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            E  L DWHN   I  + +R G GEQG    +  AE  +Q   Y+ENG++ Y SDKIS+ RSL DIRHP C +  YL++LP+ S+IIPFH E WS L+RTV SV+ R+P  L+ E++LVDD S +  L+K LE ++   +P  ++LRT  R+GLIRTR+LGA  A GDV+ FLDSH EANVNWLPPLL+ IA+N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  ++ P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R  L+CK+F WFM ++A+DL   YP +EP     GEI+        +C D K    G  + L  C+    +      Q F  +W+ +I+P D    +  C D+  H     V L+ CH  +GNQ +KY+ + + +    SG C++   +   I + TCN +   Q+W++   N T L+  +
Sbjct:   68 EQRLKDWHNKEAIRRDAQRVGNGEQGKPYPMTDAERVDQA--YRENGFNIYVSDKISLNRSLPDIRHPNCNSKLYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMA-LFPSVRILRTKKREGLIRTRMLGASAATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVVAQKKLRGSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNV---GTGLCTDTKHGTLGSPLRLETCIRGRGEAAWNSMQVFTFTWREDIRPGDPQHTKKFCFDAVSHT--SPVTLYDCHSMKGNQLWKYR-KDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLENFN 601          

Query:  220 ESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEG--GEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            E  L DWHN   I  + +R G GEQG    +  AE  +Q   Y+ENG++ Y SDKIS+ RSL DIRHP C +  YL++LP+ S+IIPFH E WS L+RTV SV+ R+P  L+ E++LVDD S +  L+K LE ++   +P  ++LRT  R+GLIRTR+LGA  A GDV+ FLDSH EANVNWLPPLL+ IA+N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  ++ P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R  L+CK+F WFM ++A+DL   YP +EP     GEI+        +C D K    G  + L  C+    +      Q F  +W+ +I+P D    +  C D+  H     V L+ CH  +GNQ +KY+ + + +    SG C++   +   + + TCN +   Q+W++   N T L+  +
Sbjct:   68 EQRLKDWHNKEAIRRDAQRVGYGEQGKPYPMTDAERVDQA--YRENGFNIYVSDKISLNRSLPDIRHPNCNSKLYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMA-LFPSVRILRTKKREGLIRTRMLGASAATGDVVTFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVVAQKKLRVSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNV---GTGLCTDTKLGTLGSPLRLETCIRGRGEAAWNSMQVFTFTWREDIRPGDPQHTKKFCFDAVSHT--SPVTLYDCHSMKGNQLWKYR-KDKTLYHPVSGSCMDCSESDHRVFMNTCNPSSLTQQWLFEHTNSTVLENFN 601          

Query:  229 LVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEG--GEQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            L DWH+   I  + +R G GEQG    +  AE  +Q   Y+ENG++ Y SDKIS+ RSL DIRHP C + +YL++LP+ S+IIPFH E WS L+RTV SV+ R+P  L+ E++LVDD S +  L+K LE ++   +P  ++LRT  R+GLIRTR+LGA  A GDV+ FLDSH EANVNWLPPLL+ IA+N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  ++ P+DPFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+   A G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R  L+CK+F WFM ++A+DL   YP +EP     GEI+        +C D K    G  + L  C+    +      Q F  +W+ +I+P D    +  C D+  H     V L+ CH  +GNQ +KY+ + + +    SG C++   +   I + TCN +   Q+W++   N T L+K +
Sbjct:   71 LKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQA--YRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMA-LFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPA-GVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNV---GTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHT--SPVTLYDCHSMKGNQLWKYR-KDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFN 601          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKL 1824
            +DWHNY QI EE +R+GPGEQGS V +   EE+++  +YK NG++ YASDKIS+ R+L DIRHP CK  KYL  LP+ SV+IPFH EHW+ L+R V S+I R+P  L+ EVIL DDAS K FL + L+ +LKEH+   + +R   R+GLIRTR+LGAK A GDVLIFLDSH EANVNWLPPLLEPIA+N +T  CPFIDVI+++ F Y +QDEGARG FDW F YKR+P    D  HP++PF+SPVMAGGLFAI RKWFWELGGYD GLDIWGGEQYE+SFK+WQC G+M+D PCSR+GH+YRK++PFPN   G+F+ +N++RVA VWMDE+ E+LY RRP  +N DP +LT Q AIR+KL CK F +FM+EVAFDL   YP +EP P   GE++        +CID +FR      GL  C+S + K GGEQ   LSW  +I+PK R++C D S  +    V+LF CHG +GNQ FKY  +++QI    S  CL+ D  +K I +  C+E +  QKW +  +N  E+KKL
Sbjct:   77 IDWHNYKQIAEEKERKGPGEQGSAVILSPEEEQKKNDLYKVNGFNAYASDKISLDRALVDIRHPDCKHKKYLAKLPTASVVIPFHNEHWTTLLRNVHSLINRSPKSLLHEVILADDASTKDFLGQKLDDYLKEHFTNVRTVRAKKREGLIRTRLLGAKAATGDVLIFLDSHCEANVNWLPPLLEPIAQNRRTAVCPFIDVIDFENFAYRAQDEGARGAFDWEFFYKRLPLLPEDLRHPSEPFKSPVMAGGLFAIDRKWFWELGGYDPGLDIWGGEQYELSFKIWQCHGQMVDAPCSRVGHIYRKFAPFPNPGIGDFVGKNYRRVAVVWMDEYAEHLYRRRPHYKNIDPGDLTEQKAIRQKLKCKPFKYFMEEVAFDLKKYYPPVEPPPFAEGEVRNL---GSGLCIDTRFRGQNEKFGLETCISESPKGGGEQQLELSWHKDIRPKKRNVCFDVSSSVHKAPVILFGCHGMQGNQLFKYNSKTKQIFHPISNHCLDSDSGNKEIFMTQCDENLQSQKWTFEKLNAVEMKKL 604          

Query:   43 RFKLKNFLKFACFAALVYLIVNSV---YFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            R  L++ +K A  A + +   N +   +  + +S ++ S  A     ++        + + +  + +DWHNYT IEEEL+R GPGEQG+   +   E++ +Q +YK NG++ +ASDKI++ RSLRDIRH  CK   YL  LP  SVI+PFH EHWS L+RT  SVI R+P  LIKEVILVDD S K   ++ L+ +LKEH P  +V+R   R GLIR R+LGAK A GDVLIFLDSH+EAN NWLPPLL+PIAKN +TV CPFIDVI+Y+TF Y +QDEGARG FDW   YKR+P    D  +P +PF+SPVMAGGLFAISR++FWELGGYDEGLDIWGGEQYE+SFK+WQCGG+M+D PCSRIGH+YRK++PFPN   G+F+ RN++RVAEVWMDE+KEYLY RRP  RN  P +LT Q A+R +L CK+F WFM E+AFD V  YP +EP    SGEI+    N    CID +FR       L  C+  + + GGEQ F L+W  +I+PK R +C D S       V+L+ CHG +GNQF++YK+++  +  V +G CL+ D   K + ++ C++T   QKW ++ VNMT L
Sbjct:    2 RRNLRSIVKLAASAVIFFAAFNLISKYFLGDESSRKDDSESAKLMPRDIHFHWTKTVSPKKINGSKIDWHNYTLIEEELQRIGPGEQGAAFILSPEEDKLKQPLYKVNGFNAFASDKIALNRSLRDIRHFGCKDKVYLVDLPVASVIVPFHNEHWSTLLRTAYSVINRSPSHLIKEVILVDDFSNKEHCKQQLDDYLKEHQPKVRVVRAGKRVGLIRARLLGAKAATGDVLIFLDSHTEANTNWLPPLLDPIAKNKRTVVCPFIDVIDYETFAYRAQDEGARGSFDWELFYKRLPLLPEDLENPTEPFKSPVMAGGLFAISREYFWELGGYDEGLDIWGGEQYELSFKIWQCGGEMVDAPCSRIGHIYRKFAPFPNPGIGDFVGRNYRRVAEVWMDEYKEYLYSRRPHYRNISPGDLTEQKALRTRLQCKSFKWFMTEIAFDQVKKYPPVEPPDFASGEIRNVATN---YCIDTRFRGENEKFNLEKCIKDDEQGGGEQQFALTWHKDIRPKKRLVCFDVSSSEDKAPVVLWNCHGMQGNQFWQYKVDTNHLQHVITGTCLDADVERKDLFMRKCDDTSKTQKWKFSFVNMTAL 592          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKK 1821
            +DWH+Y  I EE +R G GEQGS V +   EE+++  +YK NG++ YASDKIS+QR+L+DIRH  CK  KYL  LP+ S+I+PFH EHWS L+RT  SVI R+P  L++EVILVDD S K   ++ L+ ++ EHY   +++R   R+GLIRTR+LGA+ A GDVLIFLDSH E N+NWLPPLL+PIA++ KTV CPFIDVI+Y+TF Y +QDEGARG FDW F YKR+P    D+ HPADPF+SPVMAGGLFAI ++WFW LGGYD GLDIWGGEQYE+SFK+WQCGG M+D PCSRIGHVYRK++PFPN   G+FI RN+KRVAEVWMDE+ EYLY RRP  +  D  +LT Q AIR+KLHCK+F WFM EVAFDLV  YP IEP P+ SGE++  N  N   CID +F+       L  C+      GGEQ F  SW  +I+PK R +C D++   P   V+L+ CHG  GNQ FKY L++ QI    SG CL+ D  +  + +  C+     QKW W  +N+ ++KK
Sbjct:   25 IDWHDYKAIAEEQQRTGLGEQGSAVILTAEEEKKKGDLYKVNGFNAYASDKISLQRALKDIRHEQCKNKKYLNKLPTASIIVPFHNEHWSTLLRTAQSVIDRSPPHLLQEVILVDDFSSKEHCKQQLDDYVAEHYTKVRIVRAEKREGLIRTRLLGARAAKGDVLIFLDSHCEVNINWLPPLLDPIARDQKTVVCPFIDVIDYETFAYRAQDEGARGAFDWEFFYKRLPLLPEDKKHPADPFKSPVMAGGLFAIHQEWFWMLGGYDPGLDIWGGEQYELSFKIWQCGGMMVDSPCSRIGHVYRKFAPFPNPGVGDFIGRNYKRVAEVWMDEYAEYLYKRRPHYKTLDAGDLTEQKAIRDKLHCKSFKWFMTEVAFDLVKVYPPIEPTPMASGEVR--NQAN-EKCIDTRFKGQNERFQLESCIKDGQGAGGEQQFEFSWHKDIRPKSRAVCFDAAHSAPKSPVILYNCHGMGGNQRFKYNLQTNQIFHPVSGQCLDCDKENLEVFMNPCDADSETQKWKWEKINLKDVKK 551          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELK 1818
            +DWH+Y QI EE +R+GPGEQG  V +   EE+++  +YK NG++ +ASDKIS+QRSL+DIRH  CK+ KYL  LP+ SVI+PFH EHW+ L+R   SV+ RAP G++ E+IL DD S K   +K L+ +LKEH+   +V+R   R+GLIRTR++GAK A G VLIFLDSH EAN+NWLPPLLEPIA++YKTV CPFIDVI+++TF Y +QDEGARG FDW F YKR+P    D  HPA+PF SPVMAGGLFAIS KWFWELGGYD GLDIWGGEQYE+SFKLWQCGGKM+D PCSRIGH+YRK++PFPN   G+F+ RN++RVAEVWMDE+ EYLY  RP  RN D  +++ Q AIR KL+CK F WFM++VAFDL   YP +EP P   GEI+  + N   +CID +++       L PCL  + K GGEQ F  SW  +I+P  R +C D S  I    ++LF CHG  GNQ FKY L++ QI  V S  CL+ D  S  +    C++ +  Q+W   +VN T L+
Sbjct:   71 IDWHSYKQIAEEEERKGPGEQGQAVILSPEEEKQKNDLYKVNGFNAFASDKISLQRSLKDIRHADCKSKKYLNHLPNASVIVPFHNEHWTTLLRLCYSVLNRAPKGMVHEIILADDFSNKEHCKKPLDDYLKEHFDNVRVVRAKQREGLIRTRIMGAKAATGQVLIFLDSHVEANINWLPPLLEPIAEDYKTVVCPFIDVIDFETFAYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPAEPFNSPVMAGGLFAISTKWFWELGGYDPGLDIWGGEQYELSFKLWQCGGKMVDAPCSRIGHIYRKFAPFPNPGVGDFVGRNYRRVAEVWMDEYAEYLYNHRPHYRNIDTGDISAQKAIRTKLNCKPFKWFMEKVAFDLPKFYPPVEPPPFAKGEIRNVDAN---LCIDTRYKGQNERFQLEPCLK-DGKGGGEQEFQFSWHKDIRPGKRSVCFDVSQSIKKSPIILFNCHGMGGNQRFKYNLDTSQIYHVISNQCLDCDAGSHELFTNPCDKNLKSQQWKIQTVNETALR 595          

Query:   58 NFLKFACFAALVYLIVNS--VYFRNPNSIENSSNVATTQSVELSTEELLISTSEHLES----------NLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYP-IAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKK 1821
            + LK+   AAL +L +    V F  P+  ++ +     + + +    ++  ++   ES            +DWH+Y  IE E +R GPGEQG+ V +   EE+++  +YK NG++G+ASDKIS+QRSL+DIRHP C+T KY   LP+VSV++PFH EHWS L+RT +SV+ R+P  LI E+ILVDD S K    K L+  L  HY    KV+    R+GLIRTR+ GA+EA GDVLIFLDSH EANVNWLPPLL+PIA++Y+TV CPFIDV++Y+TF Y +QDEGARG FDW F YKR+P    D  HPA PF+SPVMAGGLFAIS KWFWELGGYD GLDIWGGEQYE+SFKLWQCGG+MLD PCSR+GH+YRK++PFPN   G+F+ RN++RVAEVWMDE+ E+LY RRP  R+  P N+T Q AIR+KL+CK F WFM+E+AFDL   YP IEP  V  GE++    N   +C+D +F+  G   GL  C       GGEQ   ++W  +I+P  R  C D S  +    V+L+ CHG +GNQ+FKY  E+ Q+    S  CL+ D   K I + +C++    QKW +  VN+ + KK
Sbjct:    7 SILKYLVLAAL-FLTLGPFLVKFMIPDDHDDIAPRGNAEGMPIEPGAVVRKSASDHESPEKSRADEPLQKIDWHDYKHIEIEKQRTGPGEQGAAVILSSDEEKKKDALYKVNGFNGFASDKISLQRSLKDIRHPQCRTQKYWNKLPTVSVVVPFHNEHWSTLLRTAESVLVRSPPELIHEIILVDDFSSKEHCGKPLDDHLATHYGGKVKVIHQPKREGLIRTRLAGAREATGDVLIFLDSHCEANVNWLPPLLDPIAEDYRTVVCPFIDVVDYETFAYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPARPFKSPVMAGGLFAISAKWFWELGGYDPGLDIWGGEQYELSFKLWQCGGQMLDAPCSRVGHIYRKFAPFPNPGVGDFVGRNYRRVAEVWMDEYAEFLYKRRPQYRSIQPGNITEQLAIRKKLNCKPFKWFMEEIAFDLPKKYPPIEPPAVAEGEMRNVGAN---LCVDTRFKGQGETFGLEKCAKDEPGIGGEQRLQITWHKDIRPGKRSFCFDVSTSVEKAPVILYNCHGMKGNQWFKYDTETSQVFHPISRHCLDCDAERKEIFMSSCDKDSNTQKWKFEKVNLEQAKK 603          

Query:  235 DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVS-VCIDFKFRDSGYVVGLSPCLSVNHKEGG------EQNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            DWH+   I  +  R G GE G     P AE+E    +YKENG++ Y S+ I++ RSL DIRHP CK   YL++LP+ S+IIPFH E WS L+RT+ S++ R P  LI E+ILVDD S +  L   LE ++   +P  +++RT  R+GLIRTR+LGA  A G+VL FLDSH E N+NWLPPLL+ IA+N +T+ CP IDVI+++ F Y +Q  +  RG FDW   YKRIP   +   S P++P+ESPVMAGGLFA+ R+WFWELGGYD GL+IWGGEQYEISFK+W CGG M D+PCSR+GH+YRKY P+     G  ++RN KRVAE WMDEF EY+Y RRP  R+    +LT Q  +R+ L CK+F W+M  VA+DL   YP +EP P   GEI+    N  S +C+D K   +G  + L  CL    KEG       EQ F   W+ +I+P D    R  C D+        V L+ CHG RGNQ + Y+ +      V+SG C++  PA K I +  CN     Q+W++  VN T L K +
Sbjct:   67 DWHDNESIRRDELRVGKGEHGKPY--PLAEDECDDSVYKENGFNIYVSNNIALDRSLPDIRHPNCKQKLYLENLPNTSIIIPFHNEGWSSLLRTIHSIVNRTPDHLIAEIILVDDYSDRDHLGARLEDYMSR-FPKVRIVRTKKREGLIRTRLLGASVAKGEVLTFLDSHCETNINWLPPLLDQIAQNPRTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPLELQGSDPSNPYESPVMAGGLFAVRRQWFWELGGYDTGLEIWGGEQYEISFKVWMCGGSMYDVPCSRVGHIYRKYVPY-KVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDLTAQKELRKHLKCKDFKWYMNTVAWDLPKYYPPVEPLPAAWGEIR----NAASGLCVDSKHGSTGTELRLDTCL----KEGAERTWAHEQIFTFGWREDIRPGDPLHTRKFCFDAISQ--SSPVTLYDCHGMRGNQHWSYRKDKSLYHLVSSG-CMDCSPADKRIFMNKCNPQSETQQWLFQRVNTTILDKFN 595          

Query:  319 AEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP---RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNV--SVCIDFKFRDSGYVVGLSPCLSVNHKEGGE--QNFILSWKGEIKPKD----RDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
             + +   + Y+ENG++ Y S++IS+ RSL DIRHP CK   Y + LP+ S+IIPFH E WS L+RTV S++ R+P  LI E+ILVDD S +  L+ +LE ++    P  ++LRT  R+GLIRTR+LGA  A G+V+ FLDSH EANVNWLPPLL+ IA+N K + CP IDVI++D F Y +Q  +  RG FDW   YKRIP     + D+  P++PFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+     G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++T Q  +R +L+CKNF WFM +VA+DL  +YP +EP     GE++     NV   +C++ K   SG  + +  C+    +      Q F   W+ +I+  D    + +C D+  H     V L+ CHG +GNQ ++Y+ + + +    S  C++ +P  K + + +C+ +I  Q+W++   N T L + +
Sbjct:    2 TDADRVDQAYRENGFNIYVSNRISLNRSLPDIRHPNCKLKLYSERLPNTSIIIPFHNEGWSSLLRTVHSILNRSPPELIAEIILVDDFSDREHLKASLEDYMVR-MPKVRILRTKKREGLIRTRLLGAAAAKGEVITFLDSHCEANVNWLPPLLDRIAQNRKAIVCPMIDVIDHDNFGYETQAGDAMRGAFDWEMYYKRIPIPAELQKDD--PSEPFESPVMAGGLFAVDRKWFWELGGYDTGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPY-KVPGGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVTTQKELRARLNCKNFKWFMTDVAWDLPKHYPPVEPPAAAWGELR-----NVGSGLCMESKHFSSGTPLRMEVCVKGRGETAWSHGQVFTFGWREDIRVGDPLHTKKVCFDAISH--NSPVTLYDCHGMKGNQLWRYR-KDKTLYHPISNSCIDHNPNEKRVFMNSCDASIATQQWVFERTNSTVLDQFN 504          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP--LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHI--ALQTCNETITDQKWIWTSVNMT 1809
            GPGE G  V IPK ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ S++I FH E WS L+RTV SVI R+P  L+ E++LVDDAS + FL+K LE ++K      ++LR   R GLIR R+ GA    G V+ FLD+H E  V WL PLL  I ++ K V CP IDVI+ +TFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK++ Y+  P +   D  +++ + A+RE L CK FSW+++       N YP   I       GEI+    N    C+D   R     VG   C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ F+Y  E   +L VNS  CL+       +   L+ CN + + Q   W   NMT
Sbjct:   56 GPGEMGKAVIIPKDDQEKMKELFKINQFNLMASDMIALNRSLPDVRLDGCKTKVYPDDLPNTSIVIVFHNEAWSTLLRTVHSVINRSPRHLLVEILLVDDASERDFLKKKLEDYVKTLEVPVRILRMEQRSGLIRARLRGAAATRGQVITFLDAHCECTVGWLEPLLSRIKEDRKAVVCPIIDVISDETFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRSYFEEIGTYDPGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYSFPGGT-GQVINKNNRRLAEVWMDEFKDFFYIISPGVVRVDYGDVSARKALREALQCKPFSWYLE-------NIYPDSQIPRRYFSLGEIRNVETNQ---CVDNMGRKENEKVGFFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--NGPVVMLKCHHMKGNQMFEYDAERLTLLHVNSNQCLDMPSEEDKMVPTLRDCNGSRSQQ---WLLRNMT 553          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLE--GDPASKHIALQTCNETITDQKWIWTSVNMTEL 1815
            GPGE G  V IPK + E+ + ++K N ++  AS+ I++ RSL D+R   CK   Y   LP  SV+I FH E W+ L+RTV SVI R+P  L++EV+LVDDAS + FL++ LE ++++     +++R   R GLIR R+ GA  + G V+ FLD+H E  + WL PLL  I ++ KTV CP IDVI+ DTFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  EISF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK + Y+  P +   D  ++  + ++R+KL CK FSW+++ V  D       I  +    GEI+    N    C+D   R     VG+  C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ + Y      ++ VNS  CL+   +  S+  +++ C  + + Q+W+  +V + E+
Sbjct:   55 GPGEMGKPVVIPKEQHEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKNKVYPDDLPRTSVVIVFHNEAWTTLLRTVHSVINRSPRHLLEEVVLVDDASERDFLKRKLEQYVRKLEVPVRIVRMEQRSGLIRARLKGASLSTGQVITFLDAHCECTMGWLEPLLSRIKQDKKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGT-GQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDIATRASLRQKLQCKPFSWYLENVYPD-----SQIPRHYYSLGEIRNVETNQ---CLDNMARKENEKVGIFNC----HGMGGNQVFSYTANKEIRTD--DLCLDVSKL--NGPVMMLKCHHLKGNQLWDYDPLKLSLVHVNSNQCLDKASEDDSQVPSVRDCTGSRS-QQWLLRNVTLPEI 556          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP--LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCL 1716
            GPGE G  V IPK ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ S++I FH E WS L+RTV SVI R+P  L+ E++LVDDAS + FL+K LE ++K      ++LR   R GLIR R+ GA    G V+ FLD+H E  V WL PLL  I ++ K V CP IDVI+ +TFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK++ Y+  P +   D  +++ + A+RE L CK FSW+++       N YP   I       GEI+    N    C+D   R     VG   C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ F+Y  E    + + +  CL
Sbjct:   56 GPGEMGKAVIIPKDDQEKMKELFKINQFNLMASDMIALNRSLPDVRLDGCKTKVYPDDLPNTSIVIVFHNEAWSTLLRTVHSVINRSPRHLLVEILLVDDASERDFLKKKLEDYVKTLEVPVRILRMEQRSGLIRARLRGAAATRGQVITFLDAHCECTVGWLEPLLSRIKEDRKAVVCPIIDVISDETFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDRSYFEEIGTYDPGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYSFPGGT-GQVINKNNRRLAEVWMDEFKDFFYIISPGVVRVDYGDVSARKALREALQCKPFSWYLE-------NIYPDSQIPRRYFSLGEIRNVETNQ---CVDNMGRKENEKVGFFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--NGPVVMLKCHHMKGNQMFEYDAEKGTFMHIITQSCL 523          

Query:  301 GVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPI-AKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHP---ADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLI----------EPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFK-------YKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKW 1785
            G+   + ++E +   Y+++ ++   S+++   R++ D RHP C T  Y   LP+ SV+I F+ E  S L+RTV SV  R P  L+ EV+LVDD S    L++ LE  LKE +P   K++R   R+GLIR R++GA  A GDVL+FLDSH E NV WL PLL  +A+N  TV CP ID++N DTF Y S     RG F+W   ++  P   S  S P     P +SP MAGGLFA+ RK+F +LG YD G+DIWGGE  EISF++W CGG +  IPCSRIGH++RK  P+ + A  + +SRN  R+A VW+DE+KE     RP +R  +  +++ + A+RE+L C+ F W+++ V  ++    P +           P PV  G ++        V  +      G VV + PC S +     EQ ++ +   E++  +  +C+D  +  P  S  L KCHG  G+Q +        Y++   Q L V S   ++G      + ++ CN +   Q+W
Sbjct:    1 GMIYSREDQETRDLGYQKHAFNLLISNRLDPHRTIPDTRHPRCATKSYPAQLPTASVVICFYNEAVSALLRTVHSVTERTPPALLHEVLLVDDFSDLVDLREGLEKELKEKFPKKVKLVRNEKREGLIRGRMVGANHATGDVLVFLDSHCEVNVAWLEPLLARVAENPSTVVCPIIDIVNPDTFLY-SASPLVRGGFNWGLHFRWDPVPSSLLSGPDGEMAPIKSPTMAGGLFAMDRKYFNKLGQYDGGMDIWGGENLEISFRIWMCGGSLEIIPCSRIGHIFRKRRPYGSPAGADTMSRNSLRLAHVWLDEYKEQYLALRPELREREYGDVSERKALRERLGCRPFRWYLQNVYPEIEVGRPQLPQAVLSKMHKRPKPVQRGRLRHLQTGKCLVAHNDPSEKGGLVV-VRPCDSGDI----EQVWVYNEGQELQLANL-LCLDMPEMEPRASPRLMKCHGSGGSQQWTMGKFNRLYQVSLGQCLQVKSMTDVKG-----RVVMEICNGS-EQQQW 503          

Query:  427 CKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDW--NFDYKRIPRFKSD--ESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP--LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILF--VNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMT 1809
            CKT  Y   LP  SV+I FH E WS L+RTV S+I R+P  +++E+ILVDDAS + FL+  LE +  +      ++R   R GLIR R+ GA  + G V+ FLD+H E    WL PLL  I  + K V CP IDVI+ +TFEYL+  +   G F+W  NF +  +P+ + D  +     P  SP MAGGLFAI R +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMD FK++ Y+  P +   +  +++ + A+R++L CK FSWF++ V       YP   I  +    GE++    N    C+D   R     +G+  C    H  GG Q F  S+  + + +  D+C+D S     G VL+ KCH  +GNQ + Y  + Q+++    NS  CL+     +   + T  E    +   W   NMT
Sbjct:    1 CKTKVYPDGLPKTSVVIVFHNEAWSTLLRTVHSIIGRSPRHMLEEIILVDDASERDFLKSPLEEYASKLPVPVHIVRMESRSGLIRARLRGAAVSRGQVITFLDAHCECTTGWLEPLLARIKADRKNVVCPIIDVISDETFEYLAGSDMTYGGFNWKLNFRWYPVPQSEMDRRKGDRTIPVRSPTMAGGLFAIDRDYFQEIGTYDAGMDIWGGENLEMSFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGT-GQVINKNNRRLAEVWMDNFKDFFYIISPGVTKVEYGDVSQRKALRDRLKCKPFSWFLENV-------YPNSQIPRHYYSLGEVRNVETNQ---CLDNMGRKENEKIGIFNC----HSMGGNQVF--SYTADKELRTDDLCLDVSRM--NGPVLMLKCHHMKGNQLWDYDQQMQKLIMRHTNSNQCLD-KATEQDRQVPTMRECDGGRSQQWILRNMT 451          

Query:  151 NVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKR----------RGPGEQGSGVRIPKAEEEEQQRIYKEN----GYDGYASDKISIQRSLRDIRHPACKTLKY-LKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFE-YLSQDEGARGIFDW--NFDYKRIPRF-KSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRD---SGYVVGLSPCLSVNHKEGGEQNFILSWKGEIK-PKDRDMCMDSSDHIP 1608
             + T+ S E S        +E  ES  V       +EE+L R          R  GE     R+   E   ++++ +E+      + Y SD+IS+ R + D R   CK  K+  + LP+ SV+I F+ E WS L+RTV SV+  +P  L++E+ILVDD S + +L+  LE ++     + +++RT  R+GL+R R+LGA  A G VL FLD H E    W+ PLL+ I +    V CP ID I+++TFE Y+   E A G FDW   F +  +P   +S  +   +P +SP MAGGLFA+S+K+F  +G YD+G+++WGGE  E+SF++WQCGG +   PCS +GHV+ K +P+P   +  F+ +N  R AEVWMD +KE+ Y R P  R E   +L+ +  +REKL CK+F W++K +  DL     + E  P   G I+  N    S CID+   D   +G ++ L PC    H +GG Q F  + + +++     ++C +  D  P
Sbjct:   30 QLVTSSSREQSERAQPFEPAEKGESQEV-------VEEDLSRPLYSKPPPDERALGEWAKAARLNLPEGSSERKLEEESIERYALNIYLSDRISLHRHIPDGRMYECKAQKFDYRRLPTTSVVIAFYNEAWSTLLRTVHSVLESSPAVLLREIILVDDFSDRAYLKSPLEDYISTLERV-RLVRTTQREGLVRARLLGATHATGQVLTFLDCHCECVPGWIEPLLQRIWEKETAVVCPVIDTIDWNTFEFYMQTSEPAIGGFDWRLTFQWHGVPEHERSRRASRIEPIQSPTMAGGLFAVSKKYFDHIGTYDQGMEVWGGENLELSFRVWQCGGSLEVHPCSHVGHVFPKKAPYP---RPRFL-QNTVRAAEVWMDSYKEHFYNRNPPGRKEKYGDLSERKTLREKLGCKSFEWYLKNIYPDLH----VPEDRPGFHGAIQ--NKGIQSECIDYNAPDNNPTGAMLSLYPC----HGQGGNQFFEYTTRKDLRFNSATELCAEVRDGKP 516          

Query:  286 GEQGSGVRIPKAEEEEQQRIYKENGY--DGYASDKISIQRSLRDIRHPACKTLKY-LKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYL-SQDEGARGIFDWN--FDYKRIPRFKSDE-SHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDR--DMCMDSSDHIPGGSVLLFKCHGGRG----NQFFKYKLESQQILFVNSGFCLEG--DPASKHIALQTCNETITDQKWIW 1791
            GE G  VR+    EE+++     N +  + Y SD+IS+ R L +  +P C+  KY  + LP+ SV+I F+ E WS L+RTV SV+  +P  L+ E+ILVDD S +  L+  LE ++     + +++R   R+GL+R R+LGA  A GDVL FLD H E +V WL PLLE IA+    V CP IDVI ++TFEY+ +  E   G FDW   F +  +P  +      P D   SP MAGGLFA+S+K+F  LG YD G+++WGGE  E SF++WQCGG +   PCS +GHV+ K +P+  +        N  R AEVWMD +KE  Y R P  R E   ++T +  +RE+L CK F WF++ V  D+     + E  P   G +K    +N   C D+   D   V G    L   H  G  Q F  + + EI+   R  + C    + +    + ++ CH        NQ F ++ E   I  + +  CLE    P S  + L    +  T Q+W++
Sbjct:   28 GEMGKAVRLNLEGEEKRKEEESINKHQINIYVSDRISLHRQLPEKWNPLCREKKYNYRQLPTTSVVIAFYNEAWSTLLRTVHSVLETSPDALLNEIILVDDYSDREHLRDRLEQYIATLRKV-RLVRARKREGLVRARLLGAGVATGDVLTFLDCHCECHVGWLEPLLERIAEEESAVVCPVIDVIEWNTFEYMGNAGEPQIGGFDWRLVFTWHTVPGHEQKRRKSPIDVIRSPTMAGGLFAVSKKYFDYLGTYDTGMEVWGGENLEFSFRIWQCGGTLEVHPCSHVGHVFPKQAPYSRSKA----LANSVRAAEVWMDGYKELYYHRNPHARMEPFGDVTERRNLRERLQCKTFKWFLENVYPDI----HVPEDRPGKFGMLKNRGLSN--YCFDYNPPDENQVTGQRIILYGCHGMGQNQFFEYTSEQEIRYNTRQPEACAAVDNGM--DYLTMYYCHSKNSPVTENQKFDFR-EDGSIFHILTQKCLEAVEQPNSGPLPLLRTCDGNTRQRWLF 530          

Query:  427 CKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWN----FDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGE------QYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP-LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKC 1635
            C+   +  SLP+ SVII FH E  S L+RTV SV+ ++P  LI+E+ILVDD S  P   K L    K      K +R   R+GL+R+RV GA  A   +L FLDSH E N +WL PLLE +A++   V CP IDVIN D F+Y+      +G F+WN    +DY    + K+ ++ P  P  +P++AGGLF + + +F ELG YD  +DIWGGE      + EISF++WQCGG +  IPCSR+GHV+RK  P  FP  + G   +RN +R AEVWMDE+K + Y   P+ R+    N+  +  +REKL CK F W++  V       YP L  P+     ++        + C+D     +   VG+  C    H  GG Q +  +   E   K  D+C+  +D IPGG + L  C
Sbjct:    1 CRYQTWGPSLPATSVIITFHNEARSTLLRTVVSVLNKSPAHLIREIILVDDYSDDPEDGKLLAKIEK-----VKTIRNEKREGLMRSRVRGADIAESAILTFLDSHCECNEHWLEPLLERVAEDRTRVVCPIIDVINMDNFQYVGASADLKGGFEWNLVFKWDYLTPEQRKARQTTPTSPIRTPMIAGGLFVMEKAYFEELGKYDMMMDIWGGENLGSAPRAEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYSFPGGS-GTVFARNTRRAAEVWMDEYKNFYYAAVPSARSVSFGNIQGRLELREKLKCKPFKWYLDNV-------YPELRVPD---KQDVAFGALQQGANCLDTMGHFADGTVGVYEC----HNAGGNQEWAFT--KEKSLKHIDLCLTVTDRIPGGLLKLQVC 394          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRI---PRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKY 1668
            GPGE G  V     +E ++   Y E G++ + SD+IS++R++ D RH ACK   Y  +LP  SV+I FH E WS L+RTV +V+ R+P  +++E+++VDD S K FL++ L+ + K+   I K++RT  R GLI+ RV+GA  A+G+V+IFLD+H E N  WLPPLLE IA N +T  CP ID I++ TF+Y   D   RG F+W FDYK     P   +    P    +SPVMAGGLFAI+R++F ELG YD G+ IWGGEQYEISFKLWQCGG++ +IPCSR+GHVYR + P+    K +    NF+RVAEVWMDE+K++LY +RP I++ D  +++++ A+R++L CK+F W+++ VA D V          +C+   ++ N    ++C+D   R  G+ VGL+ C    H  GG Q F  ++  E++    + C D  +  PG  V  F CH  +GNQ F +
Sbjct:    1 GPGENGEPVETKAEDESKKDAAYSEFGFNQFVSDQISLERTISDTRHQACKQRSYPINLPKASVVIVFHNEGWSTLMRTVHTVLLRSPPHMLQEIVMVDDFSNKDFLKQKLDDYTKKLGKI-KIVRTKERVGLIKARVIGANNAVGEVVIFLDAHCECNKGWLPPLLERIALNRRTAVCPTIDFIDHKTFQYKPMDPYIRGTFNWRFDYKERAVRPEEMAKRRDPTQEVKSPVMAGGLFAINREFFSELGQYDPGMFIWGGEQYEISFKLWQCGGQLENIPCSRVGHVYRHHVPY-TYPKHDATLVNFRRVAEVWMDEYKDWLYDKRPEIKSVDYGDISDRIALRKRLKCKSFKWYLENVANDTVK-------TKLCAC-FQVRNQGK-NMCLDSMGRKDGH-VGLASC----HNMGGNQAFQYTYIRELRTD--ETCFDVHESFPGAKVHFFPCHEMKGNQEFLF 448          

Query:  277 RGPGEQGSGVRIPKAEEEEQQRI----YKENGYDGYASDKISIQRSLRDIRHPACKTL--KYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYL-SQDEGARGIFDWN--FDYKRIP----RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP---FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLE-GDPASKHIALQTCNETITDQKWIWT 1794
            R   + G G +    E EE +++    +  + ++   SDKIS+ R+L D+R   CK     Y   LP+ SVII FH+E  S L+RTV SVI R P  L+ EVI+VDD S+   L K L+  + + +   KVLR   R+GL+R R+ GA  A GDVL FLDSH EA   W  PLL  IA + + V CP I+VIN DTF Y  S +   RG F W+  F +K IP    + ++D+S   DP  +P MAGGLF+I R++F+++G YDE +DIWGGE  E+SF++W CGG++  + CSR+GHV+RKY+    FP+  +   +++NF R+AEVWMDE+K+  Y ++P  +N D  +++ +  +R++L CK+F W++  +  D+     + E +P   GE++  + N     +  K   +   VG+  C    H +GG Q  +  +       + + C D S   PG  V L KCHG RGNQ +K+  E   ++   +  CL+ G P+ ++  +  C+   + Q+W+++
Sbjct:    2 RNTHQLGGGGKPAFLESEENKKLAEKYFANHSFNWLLSDKISLDRTLDDVRSERCKAKHNTYPAKLPTTSVIICFHKERLSVLLRTVHSVINRTPPELLAEVIVVDDFSQDAKLGKPLDDHVAQ-FTKVKVLRMKKREGLVRARLQGANTAKGDVLTFLDSHCEATPGWAEPLLARIAADRRNVVCPAIEVINADTFAYQGSTNADQRGGFSWDLFFKWKGIPPEEQKLRNDDS---DPIRTPTMAGGLFSIHRQYFFDIGSYDEEMDIWGGENLELSFRVWMCGGRLEIVTCSRVGHVFRKYTSPYKFPDGVE-RTLTKNFNRLAEVWMDEYKDLYYNKKPQAKNSDYGDISKRLELRKRLKCKSFKWYINNIYPDV----QMPELDPPARGEVRNPSSNQCLDSLGAKPEHNAR-VGIYTC----HGQGGNQ--VSKYMPRELIFEEENCFDVSKTHPGAPVELMKCHGMRGNQEWKHDREKGTLMHFTTQQCLDRGSPSDQYAVMNPCDGRES-QRWVFS 507          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLK--YLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDE-GARGIFDWN--FDYKRIPRF-KSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP---FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRP-TIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKW 1785
            G G+ G    +P   +E     +  + ++   SD+IS+ R L+D+R P CK     Y ++LP+ SVII FH E  S L+RTV SV+  +P  LI ++ILVDD S    L++ L   +     + K++R   RQGL+  R+ GA+EA G+VL FLDSH EA   WL PLL  IA++ + V CP I+VIN D F Y + D    RG F W+  F +K IP   K       D   SP MAGGLFAI +K+F++LG YD  ++IWGGE  E+SF++W CGG++  +PCSR+GHV+RKY+    FP       ++RNF R+AEVWMDE+K++ Y ++    RN D  +++++ A+R++L CK+F W++  +  D+ N  P    + + S +I+       S+C+D     +   VGL  C    H  GG Q F L+   EI   D D C+DS +  PG  V +  CHG +GNQ +K+      I+ V +  CL+     + I +  C+ + T Q+W
Sbjct:    1 GLGDLGEAATLPTRFKEHAAHAFDNHSFNVMLSDRISLDRRLKDVRGPKCKRKHKLYPRALPTTSVIICFHNEALSVLLRTVHSVLNESPPRLIADIILVDDYSEYDDLKQPLIDHISMLNKV-KLIRMPSRQGLVPARLRGAEEARGEVLTFLDSHCEATPGWLEPLLVRIAEDRRNVVCPVIEVINADDFRYQASDVIHERGGFTWDLFFTWKAIPEAEKKRRKDETDYIRSPTMAGGLFAIHKKYFYDLGSYDSKMEIWGGENLEMSFRIWMCGGQLEIVPCSRVGHVFRKYTSPYKFPKGTTTT-LARNFNRLAEVWMDEYKDHYYRKKTEEERNVDIGDISDRVALRKRLGCKSFKWYLDNIYPDMTNKLP--PKSYLYSHQIR---NKESSLCLDTLGEKNIKRVGLYTC----HGMGGNQFFTLTKSNEILFND-DKCLDSPNGDPGSYVEMITCHGLKGNQEWKHNKRMGTIVHVWTENCLDISQDGQFIIVNPCDGSST-QRW 499          

Query:  328 EEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYK---RIPRFK-SDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASK--HIALQTCNETITDQKWIWTSVNM 1806
            +E +  Y +N ++   SDKI   R + D RH  C+   Y  +LP+ S+II FH E  S L+RTV S++ + P  L+ E+ILVDD     F     +  L    P  KVLR N RQGLIR+RV G+  A  DVL FLDSH E N +WL PLL+ + +N K V  P IDVIN D F Y+      +G FDW+  +K     P  K S  S P  P ++P++AGGLF +++ WF E+G YD  +DIWGGE +EISF+ WQCGG M  IPCSR+GHV+RK  P  FP+     ++ +N +R AEVWMDE+K + Y  RP  R+    ++ ++  +R++L CK F W+++ V  +L     + +   V  GE+K         C+D     +G  VG+  C    H + G Q + L+ K  ++  D  + + S     GG+V L  C  G   Q ++       +    SG CL+   A    H+  + C      Q W + S+NM
Sbjct:   15 KEGEDAYGKNQFNQAISDKIGGDRDVPDTRHSHCRYEAYPSTLPATSIIITFHNEARSTLLRTVKSILNKTPPNLVNEIILVDD-----FSDDAEDGLLLMGLPKVKVLRNNKRQGLIRSRVKGSDTAKSDVLTFLDSHCECNTDWLQPLLKRVVQNKKAVVSPIIDVINMDDFSYIGASADIKGGFDWSLHFKWDNLTPEQKQSRRSTPIAPIKTPMIAGGLFVVTKSWFEEMGKYDTMMDIWGGENFEISFRTWQCGGSMEIIPCSRVGHVFRKRHPYTFPDGNANTYM-KNTRRTAEVWMDEYKRFYYAARPMARSALYGSIKSRKELRKRLQCKPFKWYLQNVYPEL----QIPDSQDVSFGELKQGKS-----CLDTLGSQAGGSVGMFDC----HGQAGNQEWALTKKSTVRHLDLCLTLGS-----GGAVTLEGCRDGDPKQIWEQTSPQHTLRHKQSGLCLDSKEAKSGGHVRGEHCKRGEFAQIWQF-SLNM 490          

Query:  346 YKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPAD---PFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEV-------------AFDLVNNYPLI---EPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNF-ILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHI--ALQTCNETITDQKWIWTSV 1800
            Y  +G++   S+++S+ R+++D RH  C+   Y K+LP  S++I F+ E W+ L+RT+ SV+ R P   + E+ILVDD S    L+  L+ +L    P  +++R N R+GLIR R++GA+ A G VL+FLDSH E N+NWL PLL+ I  + K V CP IDVI+ DTFEY S     RG F+W   +   P   S    P D   P  SP MAGGLFA+ R++F +LG YD G+DIWG E  EISF++W CGG +  +PCSR+GH++R++ P+ +++KG+ +SRN  R+AEVW+D +K+Y Y  R  +  +   +++ +  +R+ L CK+F W++K +             AF  ++  P +   +   +C   I+L    +   C+D      G+         ++  E  +  F  L+  GE+K +   +C+++S +     + L KCH   G Q +K+  +   +    +G CL  + +  +    +Q C+ +I  Q   WT V
Sbjct:   18 YSAHGFNLLISNRLSLHRTIKDTRHELCRGKTYPKNLPVASIVICFYNEAWTILLRTIHSVLDRTPHQFLHEIILVDDFSNMLELKSKLDRYLST-MPKIRIVRNNKREGLIRGRIIGAEAATGQVLVFLDSHCEVNINWLQPLLQHIHDDQKAVACPVIDVISSDTFEY-SSSPMVRGGFNWGLHFTWEPIPPSLLVKPEDYVKPIRSPTMAGGLFAVDREYFTQLGKYDSGMDIWGAENLEISFRIWMCGGSLDILPCSRVGHLFRRFRPYGSDSKGDTMSRNSMRLAEVWLDGYKKYFYQIRHDLEGKKFGDISQRIKLRKSLQCKSFEWYLKNIYPELKPPGQPGGGAFYPIDRRPQVVIWKGKVIC---IQLQTSFDDGYCLD----SPGHPSEKKASAVIHQCESTKSRFWSLNEDGELKIESL-LCLEASGYQSKLGLRLMKCHAQGGGQQWKFLNKKSVLYHPATGLCLGVNESRTYSTPGMQICDYSIHQQ---WTFV 511          

Query:   43 RFKLKNFLKFA--CFAALVYL-------IVNSVYFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP-RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLS--VNHKEGGEQNFILSWKGEIKPKD----RDMCMDS-SDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELK 1818
            R K K  L+ A    AAL++L       +     F N    +    +   Q V     + L+      +    DWH+Y  I  +  R G GEQG    +  A+  +Q   Y+ENG++ + SD+IS+ RS+ DIRHP CK   Y + LP+ S+IIPFH E WS L+RTV SV+ R+P  LI E+ILVDD S K  L+  LE ++    P  ++LRT  R+GLIRTR+LGA  A G+V+ FLDSH EAN+NWLPPLL+ IA N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP   +  ++ P++PFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+     G  ++RN KRVAEVWMDE+ EY+Y RRP  R+    ++  Q  +R  L+CK+F WFMKEVA+DL  +YP +EP     GE++ +      +C++ K   SG  + L  C+    +   G  Q F   W+ +I+  D    + +C D+ S H P   V L+ CHG RGNQ ++Y+ + + +    S  C++ + + + + +  CN     Q+W++   N T L+
Sbjct:    2 RRKEKRLLQVAGLLIAALLFLPNVGLWSLYRDRVFDNSPDTDGPRGIPAIQGVNRMGRDSLVGLGGTRKK---DWHDYEAIRRDATRSGNGEQGKAFPLTDADRVDQA--YRENGFNIFVSDRISLNRSVPDIRHPNCKQKLYAERLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPQLIAEIILVDDFSDKDHLKGALEEYMVR-LPKVRILRTKKREGLIRTRLLGAAAAKGEVITFLDSHCEANINWLPPLLDRIALNRKTIVCPMIDVIDHDNFGYETQAGDAMRGAFDWEMYYKRIPIPAELQKNDPSEPFESPVMAGGLFAVDRKWFWELGGYDTGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPY-KVPGGVSLARNLKRVAEVWMDEYAEYVYQRRPEYRHLSAGDVAAQKELRSTLNCKSFKWFMKEVAWDLPKHYPPVEPPAAAWGEVRSAAS---GLCLESKHFVSGTPIRLESCVKGRADVSWGHGQVFTFGWREDIRVGDPMHTKKVCFDAVSHHSP---VTLYDCHGMRGNQLWRYR-KDKSLYHPVSNSCVDSNASERRVFMNVCNPASASQQWLFEKTNATVLE 597          

Query:   43 RFKLKNFLKFACFAALVYLIVNSV----YFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLV---DWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQ-DEGARGIFDWNFDYKRIP---RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCL----SVNHKEGGEQNFILSWKGEIKPKD----RDMCMDS-SDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLH 1827
            R + K  L+ A       L + +V     +R+   +ENS + A    V  ST++ L      + S+ V   DWH+Y  +  +  R G GEQG     P  E +   + Y+ENG++ Y S++IS+ RSL DIRH  C+   Y + LP+ ++IIPFH E WS L+RTV SVI R+P  L+ E+ILVDD S K  L+  LE ++K  +P  ++LRT  R+GLIRTR+LGA  A G+V+ FLDSH EANVNWLPPLL+ I +N KT+ CP IDVI++D F Y +Q  +  RG FDW   YKRIP     ++D+  P +PFESPVMAGGLFA+ RKWFWELGGYD GL+IWGGEQYEISFK+W CGG+M DIPCSR+GH+YRKY P+     G  +++N KRVAEVWMDE+ EY+Y RRP  R+    +++ Q  +R  L+CKNF WFM+EVA+DL  +YP +EP     GEI+        +C++ K   SG  + L  C+     V+   G  Q     W+ +I+  D    R +C D+ S H P   V L+ CHG +GNQ ++Y+ + + +    S  C++   + + + + TC+ T   Q+W++   N T L++ +
Sbjct:    2 RRREKRLLQVAGLLVAAVLFLPNVGLWSLYRD-RVLENSPDAADGSGV-FSTKQGLHQKVAQVGSDGVRRIDWHDYKAMRRDAARAGNGEQGKP--FPVTETDRVDQAYRENGFNIYVSNRISLNRSLPDIRHENCRQKLYAEKLPNTTIIIPFHNEGWSSLLRTVHSVINRSPPRLVAEIILVDDFSDKEHLKVALEEYMKR-FPKVRILRTKKREGLIRTRLLGAGAAKGEVITFLDSHCEANVNWLPPLLDRIVQNRKTIVCPMIDVIDHDNFGYDTQAGDAMRGAFDWEMYYKRIPIPAEMRTDD--PTEPFESPVMAGGLFAVDRKWFWELGGYDTGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPY-KVPGGISLAKNLKRVAEVWMDEYAEYVYQRRPEYRHLSAGDMSAQKELRSHLNCKNFRWFMEEVAWDLPKHYPPVEPPAAAWGEIRSVGS---GMCMEIKHFVSGSPIRLESCVKGRGDVSWSHG--QVLTFGWREDIRVGDPMHTRKVCFDAVSHHSP---VTLYDCHGMKGNQLWRYR-KDKSLFHPVSNSCIDSSASERRVFMNTCDPTSLSQQWLFERTNDTVLERFN 599          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP--LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHI--ALQTCNETITDQKWIWTSVNMT 1809
            GPGE G  V I K ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ S++I FH E WS L+RTV SVI R+P  L+ E++LVDDAS + FL+K LE +++      K+LR   R GLIR R+ GA    G V+ FLD+H E    WL PLL  I ++   V CP IDVI+ +TFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I + +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK++ Y+  P +   D  +++++ A+RE L CK F+W+++       N YP   I       GEI+    N    C+D   R     VG   C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ F+Y  E   +L VNS  CL+       +   L+ CN + + Q   W   NMT
Sbjct:   56 GPGEMGKAVNIAKDDQEKMKELFKINQFNLMASDMIALNRSLPDVRLDGCKTKVYADDLPTTSIVIVFHNEAWSTLLRTVHSVISRSPRHLLVEIVLVDDASERDFLKKKLEGYVRTLEVPVKILRMEQRSGLIRARLRGAAATTGQVITFLDAHCECTEGWLEPLLARIKEDRTAVVCPIIDVISDETFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDKMYFEEIGSYDPGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYSFPGGT-GQVINKNNRRLAEVWMDEFKDFFYIISPGVMRVDYGDVSSRKALREALKCKPFAWYLE-------NIYPDSQIPRRYYSLGEIRNVETNQ---CVDNMGRKENEKVGFFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--NGPVVMLKCHHMKGNQMFEYDAERLTLLHVNSNQCLDMPSEEDKMVPTLRDCNGSRSQQ---WLLRNMT 553          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP--LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHI--ALQTCNETITDQKWIWTSVNMT 1809
            GPGE G  V I K ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ S++I FH E WS L+RTV SVI R+P  L+ E++LVDDAS + FL+K LE +++      K+LR   R GLIR R+ GA    G V+ FLD+H E    WL PLL  I ++   V CP IDVI+ +TFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I + +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK++ Y+  P +   D  +++++ A+RE L CK F+W+++       N YP   I       GEI+    N    C+D   R     VG   C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ F+Y  E   +L VNS  CL+       +   L+ CN + + Q   W   NMT
Sbjct:   56 GPGEMGKAVNIAKDDQEKMKELFKINQFNLMASDMIALNRSLPDVRLDGCKTKVYADDLPTTSIVIVFHNEAWSTLLRTVHSVISRSPRHLLVEIVLVDDASERDFLKKKLEGYVRTLEVPVKILRMEQRSGLIRARLRGAAATTGQVITFLDAHCECTEGWLEPLLARIKEDRTAVVCPIIDVISDETFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDKMYFEEIGSYDPGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYSFPGGT-GQVINKNNRRLAEVWMDEFKDFFYIISPGVMRVDYGDVSSRKALREALKCKPFAWYLE-------NIYPDSQIPRRYYSLGEIRNVETNQ---CVDNMGRKENEKVGFFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--NGPVVMLKCHHMKGNQMFEYDAERLTLLHVNSNQCLDMPSEEDKMVPTLRDCNGSRSQQ---WLLRNMT 553          

Query:  280 GPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIP-------RFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSP--FPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYP--LIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHI--ALQTCNETITDQKWIWTSVNMT 1809
            GPGE G  V I K ++E+ + ++K N ++  ASD I++ RSL D+R   CKT  Y   LP+ S++I FH E WS L+RTV SVI R+P  L+ E++LVDDAS + FL+K LE +++      K+LR   R GLIR R+ GA    G V+ FLD+H E    WL PLL  I ++   V CP IDVI+ +TFEY++  +   G F+W  +++  P       R K D + P     +P MAGGLF+I + +F E+G YD G+DIWGGE  E+SF++WQCGG +  + CS +GHV+RK +P  FP    G  I++N +R+AEVWMDEFK++ Y+  P +   D  +++++ A+RE L CK F+W+++       N YP   I       GEI+    N    C+D   R     VG   C    H  GG Q F  +   EI+    D+C+D S     G V++ KCH  +GNQ F+Y  E   +L VNS  CL+       +   L+ CN + + Q   W   NMT
Sbjct:   56 GPGEMGKAVNIAKDDQEKMKELFKINQFNLMASDMIALNRSLPDVRLDGCKTKVYADDLPTTSIVIVFHNEAWSTLLRTVHSVISRSPRHLLVEIVLVDDASERDFLKKKLEGYVRTLEVPVKILRMEQRSGLIRARLRGAAATTGQVITFLDAHCECTEGWLEPLLARIKEDRTAVVCPIIDVISDETFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV---RTPTMAGGLFSIDKMYFEEIGSYDPGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYSFPGGT-GQVINKNNRRLAEVWMDEFKDFFYIISPGVMRVDYGDVSSRKALREALKCKPFAWYLE-------NIYPDSQIPRRYYSLGEIRNVETNQ---CVDNMGRKENEKVGFFNC----HGMGGNQVFSYTADKEIRTD--DLCLDVSRL--NGPVVMLKCHHMKGNQMFEYDAERLTLLHVNSNQCLDMPSEEDKMVPTLRDCNGSRSQQ---WLLRNMT 553          

Query:   37 MTRFKLKNFLKFACFAALVYLIVNSVYFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLHDFN 1836
            MTRFKLKNFLKFACFAALVYLIVNSVYFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLD+PCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLHDFN
Sbjct:    1 MTRFKLKNFLKFACFAALVYLIVNSVYFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDVPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSVNMTELKKLHDFN 600          

Query:  232 VDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYP-IAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAK-GNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEI--KLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWIWTSV 1800
            +DWHNY QI EE +R G GE GS V +  +E   ++ I+K NG++G ASDK+++ RS++DIRHP CK + Y KSLPSVS+IIPF++EHWS L+RT  S + RAP GL+KE+ILVDD S K FL+  L+ +++ ++  I +VLR + R+GLIRTR+ GAK A GDVLIFLDSH EAN+NWLPPLL+PIA++Y+TVTCPFIDV+++DTFEY +QDEGARG FDW F YKR+P    D  +PA PF+SPVMAGGLFAISRKWFWELGGYD GLDIWGGEQYE+SFK+WQCGG+MLD PCSRI HVYRKY+PFP+    GNFI+RN+KRVAEVWMDE+++YLY R+P+   E+  +LT QFAIRE+L CK+F WFM E+AFDL  +YP +EP     GE+  K+ N +  S+C+D KF  S   + L+PC+  N +  GEQ F+L+W  +++ K RD C+D   ++    V+L+ CHG +GNQ +KYKL+S+Q+  V +  CL  D  ++ + + TC  + ++QKW   +V
Sbjct:   58 IDWHNYKQILEESQREGVGEHGSAVILDSSENNLKESIFKVNGFNGLASDKMALNRSVKDIRHPDCKKMLYQKSLPSVSIIIPFYEEHWSTLLRTFISALIRAPKGLVKEIILVDDCSTKEFLKDKLDQYIENNFKGIVRVLRQDKREGLIRTRLKGAKNATGDVLIFLDSHCEANINWLPPLLDPIAQDYRTVTCPFIDVLDHDTFEYRAQDEGARGAFDWEFYYKRLPLLPEDLKYPARPFKSPVMAGGLFAISRKWFWELGGYDPGLDIWGGEQYELSFKIWQCGGQMLDTPCSRIAHVYRKYAPFPSVVNIGNFIARNYKRVAEVWMDEYRKYLYRRQPSWERENAGDLTAQFAIRERLKCKSFKWFMTEIAFDLEKHYPSVEPPNSADGEVRSKVFNSDGNSLCLDAKFAKSESQIRLAPCVKDNSRLTGEQKFLLTWHEDLRLKSRDECLDVPQNMFKSPVILYSCHGQKGNQLWKYKLDSKQLYHVVTQKCLTADGPTQSVYMDTCTSS-SNQKWYLENV 583          

Query:   37 MTRFKLKNFLKFACFAALVYLIVNSVYFRNPNSIENSSNVATTQSVELSTEELLISTSEHLESNLVDWHNYTQIEEELKRRGPGEQGSGVRIPKAEEEEQQRIYKENGYDGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRRPTIRNE-DPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKEGGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLE--GDPASKHIALQTCNETITDQKWIWTSVN 1803
            M R KLK  L F      ++LI N +                +   E S E   +S+   ++   +DW N+  I+EE  R GPGEQG GV +   E E+ +++ + NGY+  ASDKIS+ RS++D+R   CK LKY   LP  S+IIPFH EHWS L+RTV S++ R+P  L+KE+ILVDD S K FL + LE ++ EH+   ++LRT  R+GLIR R+LGA EA G VLIF+DSH E  +NWLPPLL+PI  +YKT++CPFIDVI+Y+ F    QDEG RG FDWNFDYKR+PR   D +HP  PF +P+MAGGLFAIS+ WF ELGGYD GLD+WGGEQYE+SFK+W CGGKM+D+PCSR+GHVYRK++PF     GN+++RN KR+AEVWMD++K+Y+Y +   + +  DP +LT Q  +R+ L+C +F WFMK++A+DL+  YP I+  P    + K+ +  N  +C DF   + G    +S C  V++    EQN   +W+ EIKP+ RD+C+D      G  + +F CHG  GNQ + Y   S QI+ V S  C++   +P S  I +Q C+   + QKWI  ++N
Sbjct:   17 MLRIKLKKILLFFIVLLGIFLIQNIL----------------SDWKETSDEINEVSSDSQIK---IDWANHDTIDEENARVGPGEQGIGVYLTANENEKAKQLMETNGYNALASDKISVHRSIKDLRINKCKWLKYDNFLPPASIIIPFHNEHWSTLLRTVHSILHRSPDKLVKEIILVDDNSTKEFLGEKLEQYVSEHFTKVRILRTGKREGLIRARLLGANEANGTVLIFIDSHCEVGINWLPPLLQPIRDHYKTISCPFIDVISYNDFSLRPQDEGGRGAFDWNFDYKRLPRLSKDNAHPEKPFYNPIMAGGLFAISKLWFNELGGYDYGLDVWGGEQYELSFKVWMCGGKMVDVPCSRVGHVYRKFNPFAVVGLGNYLARNHKRIAEVWMDDWKQYIYQKHQKVYSSLDPGDLTEQKKLRKALNCTSFDWFMKQIAYDLLEKYP-IQKQPENLSQGKIKSEINPHLCFDFNLGNPGDPFRISNCTDVSN----EQNLAFTWEMEIKPQKRDICLDYPR--KGEELTMFSCHGMGGNQKWIYNQNSHQIVHVVSKKCIDYRYNPESLEINIQKCSRK-SSQKWILENMN 581          

Query:  364 DGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRR-PTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE-GGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWI 1788
            + +  +K+S+ R++ +++   CK L++ K+LPSVS+II F+   W  L++T   ++ R+P  LIKE++++DD +    ++  +  ++ +H+   +V+    R+GLI+ R+LGAK A G VL+F+DSH    V WLPPLLEPI +NYKTVTCPFID+ + DT  Y SQDEGARG FDWNF+Y R+PR  ++++ P DPF++P+M G +FAI+R WFWELGGYDEGL+IWGGEQ+E+SFK+W CGG+M+++PCSRI  +++    F        I +N+KR+AE+WMD +K+++Y R      + D  +++ Q  +++KL+CK+F WFM+ VA+D++  YP I  +   +  I L + +  S+C+D K+R  G  VG+  C  +   E   EQ F  +   EI+P  R++C D  +     +++L +C     NQ ++Y   S QI  + S  C++ +  S  + +  C+ + T QKWI
Sbjct:   70 NSFEEEKVSLYRTINELKITKCKWLRHNKTLPSVSIIITFYDSDWETLMQTTRMLLLRSPRRLIKEILIIDDNADNNDMRSKMNAYVSKHFTNVRVVHKTKREGLIKARLLGAKLAKGKVLVFMDSHCTVGVKWLPPLLEPIKENYKTVTCPFIDINDTDTSLY-SQDEGARGAFDWNFNYTRLPRLHNNKTDPEDPFDNPIMQGRIFAITRNWFWELGGYDEGLEIWGGEQFELSFKIWMCGGRMVNVPCSRIRCIFKDIYSFDFIHDDIKIRKNYKRIAEIWMDNWKKFIYQRHLEEYSSFDCGDISKQKKLQQKLNCKSFDWFMENVAYDILYLYPPITVSEKLNCSITLESDD--SICVDSKYRKQGDRVGIDQCNQIGRSEKNKEQRFSFTSDFEIRPGQRNLCFDYRN--SSETLMLSQCDLMNPNQKWEYNSTSHQITNIPSQKCIKVNSKSLLLLVNNCSLSSTMQKWI 541          

Query:  364 DGYASDKISIQRSLRDIRHPACKTLKYLKSLPSVSVIIPFHQEHWSPLIRTVDSVIRRAPLGLIKEVILVDDASRKPFLQKTLEIFLKEHYPIAKVLRTNGRQGLIRTRVLGAKEAIGDVLIFLDSHSEANVNWLPPLLEPIAKNYKTVTCPFIDVINYDTFEYLSQDEGARGIFDWNFDYKRIPRFKSDESHPADPFESPVMAGGLFAISRKWFWELGGYDEGLDIWGGEQYEISFKLWQCGGKMLDIPCSRIGHVYRKYSPFPNNAKGNFISRNFKRVAEVWMDEFKEYLYLRR-PTIRNEDPLNLTNQFAIREKLHCKNFSWFMKEVAFDLVNNYPLIEPNPVCSGEIKLSNPNNVSVCIDFKFRDSGYVVGLSPCLSVNHKE-GGEQNFILSWKGEIKPKDRDMCMDSSDHIPGGSVLLFKCHGGRGNQFFKYKLESQQILFVNSGFCLEGDPASKHIALQTCNETITDQKWI 1788
            + +  +K+S+ R++ +++   CK L++ K+LPSVS+II F+   W  L++T   ++ R+P  LIKE++++DD +    ++  +  ++ +H+   +V+    R+GLI+ R+LGAK A G VL+F+DSH    V WLPPLLEPI +NYKT                   DEGARG FDWNF+Y R+PR  ++++ P DPF++P+M G +FAI+R WFWELGGYDEGL+IWGGEQ+E+SFK+W CGG+M+++PCSRI  +++    F        I +N+KR+AE+WMD +K+++Y R      + D  +++ Q  +++KL+CK+F WFM+ VA+D++  YP I  +   +  I L + +  S+C+D K+R  G  VG+  C  +   E   EQ F  +   EI+P  R++C D  +     +++L +C     NQ ++Y   S QI  + S  C++ +  S  + +  C+ + T QKWI
Sbjct:   70 NSFEEEKVSLYRTINELKITKCKWLRHNKTLPSVSIIITFYDSDWETLMQTTRMLLLRSPRRLIKEILIIDDNADNNDMRSKMNAYVSKHFTNVRVVHKTKREGLIKARLLGAKLAKGKVLVFMDSHCTVGVKWLPPLLEPIKENYKT-------------------DEGARGAFDWNFNYTRLPRLHNNKTDPEDPFDNPIMQGRIFAITRNWFWELGGYDEGLEIWGGEQFELSFKIWMCGGRMVNVPCSRIRCIFKDIYSFDFIHDDIKIRKNYKRIAEIWMDNWKKFIYQRHLEEYSSFDCGDISKQKKLQQKLNCKSFDWFMENVAYDILYLYPPITVSEKLNCSITLESDD--SICVDSKYRKQGDRVGIDQCNQIGRSEKNKEQRFSFTSDFEIRPGQRNLCFDYRN--SSETLMLSQCDLMNPNQKWEYNSTSHQITNIPSQKCIKVNSKSLLLLVNNCSLSSTMQKWI 523