Estrella
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30027919 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Estrella vs. TrEMBL
Match: A0A1Z1R2Q3 (Estrella OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 718.383 bits (1853), Expect = 0.000e+0 Identity = 353/355 (99.44%), Postives = 353/355 (99.44%), Query Frame = 2 Query: 215 MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNLIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQE-VIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNRCENRYYYGSYRYECLNYGENVVTKLLLNDAYSEVSQFSIPITKL 1276 MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNN IRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQE VIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNRCENRYYYGSYRYECLNYGENVVTKLLLNDAYSEVSQFSIPITKL Sbjct: 1 MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNPIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQEVVIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNRCENRYYYGSYRYECLNYGENVVTKLLLNDAYSEVSQFSIPITKL 355
BLAST of Estrella vs. TrEMBL
Match: A0A1P8CUY3 (Estrella/neura-1 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 468.389 bits (1204), Expect = 4.945e-163 Identity = 230/232 (99.14%), Postives = 230/232 (99.14%), Query Frame = 2 Query: 452 MMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNLIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQE-VIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNR 1144 MMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNN IRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQE VIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNR Sbjct: 1 MMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNPIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQEVVIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNR 232
BLAST of Estrella vs. Planmine SMEST
Match: SMESG000026791.1 (SMESG000026791.1) HSP 1 Score: 714.146 bits (1842), Expect = 0.000e+0 Identity = 351/355 (98.87%), Postives = 351/355 (98.87%), Query Frame = 2 Query: 215 MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNLIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQE-VIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNRCENRYYYGSYRYECLNYGENVVTKLLLNDAYSEVSQFSIPITKL 1276 MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNN IRIDSSWYPANIDYVLPKWQNFLIE VSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQE VIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKN SSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNRCENRYYYGSYRYECLNYGENVVTKLLLNDAYSEVSQFSIPITKL Sbjct: 1 MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNPIRIDSSWYPANIDYVLPKWQNFLIELVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQEVVIKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNFSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDKDELACQIPQNMTQTNRCENRYYYGSYRYECLNYGENVVTKLLLNDAYSEVSQFSIPITKL 355
BLAST of Estrella vs. Planmine SMEST
Match: SMESG000041686.1 (SMESG000041686.1) HSP 1 Score: 302.753 bits (774), Expect = 9.812e-96 Identity = 159/370 (42.97%), Postives = 242/370 (65.41%), Query Frame = 2 Query: 200 ILFEQMLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRD-LNDVFNNLIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQEV-IKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDK---DELACQIPQNM--TQTNRCENRY-YYGSYR---YECLNYGENVVTKLLLNDAYSEVSQFSIPITKL 1276 +L +M+ + +F + L AV N+LNLV+VNIS+ +YK+LM +KDN+L+ASPLA+LDV LLKK+ CYKNIR++ W+ +P+IFW D YM + S++K + L+NF +K ILPPSG ++R+ WRR+ + + N I +D+SW DYVLP +FL+EF + + LCV+TKN+LLN+S Q E I+F + + NI ++ IKI +I++VKM+NES C +C VS ++AEKW+YDVS +M+NV L+LQ DI++ V +YLCK+++ I + +K ++++ K +E+AC+IP + + C +Y YG R +E L+YG V++KL +Y+E SQFSI + KL Sbjct: 301 LLLSKMIPGIKCLFLIFLYFMNSEAVKDFNKLNLVRVNISDFVYKKLMISKDNILSASPLALLDVKLLKKYHCYKNIRSSLWALPIPVIFWTDLYMERIMASVKKGNLLRNFTGDKVSILPPSGVIAFRITWRRNYIENSENTNISLDTSWQDTQTDYVLPMRHSFLMEFSDNGDGKKLCVDTKNKLLNDSMQISEMTIDFQKTAGRKRNIPDIQIKINNIRSVKMYNESNCKTQSEDKCFVSKEFAEKWSYDVSTRMMENVEIIHLNLQKDIFDAVFEYLCKNRMSIFEIELKTVRRLSKGIDNEMACKIPNKLYVIKPKPCLPKYDRYGYLRVCPHELLDYGNEVISKLNPYQSYNENSQFSITVVKL 670
BLAST of Estrella vs. Planmine SMEST
Match: SMESG000041686.1 (SMESG000041686.1) HSP 1 Score: 302.753 bits (774), Expect = 1.237e-95 Identity = 159/370 (42.97%), Postives = 242/370 (65.41%), Query Frame = 2 Query: 200 ILFEQMLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRD-LNDVFNNLIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQEV-IKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRLKKIDK---DELACQIPQNM--TQTNRCENRY-YYGSYR---YECLNYGENVVTKLLLNDAYSEVSQFSIPITKL 1276 +L +M+ + +F + L AV N+LNLV+VNIS+ +YK+LM +KDN+L+ASPLA+LDV LLKK+ CYKNIR++ W+ +P+IFW D YM + S++K + L+NF +K ILPPSG ++R+ WRR+ + + N I +D+SW DYVLP +FL+EF + + LCV+TKN+LLN+S Q E I+F + + NI ++ IKI +I++VKM+NES C +C VS ++AEKW+YDVS +M+NV L+LQ DI++ V +YLCK+++ I + +K ++++ K +E+AC+IP + + C +Y YG R +E L+YG V++KL +Y+E SQFSI + KL Sbjct: 309 LLLSKMIPGIKCLFLIFLYFMNSEAVKDFNKLNLVRVNISDFVYKKLMISKDNILSASPLALLDVKLLKKYHCYKNIRSSLWALPIPVIFWTDLYMERIMASVKKGNLLRNFTGDKVSILPPSGVIAFRITWRRNYIENSENTNISLDTSWQDTQTDYVLPMRHSFLMEFSDNGDGKKLCVDTKNKLLNDSMQISEMTIDFQKTAGRKRNIPDIQIKINNIRSVKMYNESNCKTQSEDKCFVSKEFAEKWSYDVSTRMMENVEIIHLNLQKDIFDAVFEYLCKNRMSIFEIELKTVRRLSKGIDNEMACKIPNKLYVIKPKPCLPKYDRYGYLRVCPHELLDYGNEVISKLNPYQSYNENSQFSITVVKL 678
BLAST of Estrella vs. Planmine SMEST
Match: SMESG000013666.1 (SMESG000013666.1) HSP 1 Score: 140.198 bits (352), Expect = 1.568e-37 Identity = 88/305 (28.85%), Postives = 154/305 (50.49%), Query Frame = 2 Query: 236 IFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLAASPLAILDVNLLKKHKCYKNIRTNSWSFMMPIIFWDDSYMTNVANSIQKMSKLKNFVSEKPFILPPSGFRSYRLNWRRDLNDVFNNLIRIDSSWYPANIDYVLPKWQNFLIEFVSDQNYTGLCVETKNRLLNESFQSFEFVIEFARNVRKTNNIQEV-IKIKDIQTVKMFNESGCDMGQSSRCTVSSDYAEKWAYDVSVEIMKNVSSNSLSLQSDIYEKVLQYLCKDKVPIESVGVKRL----KKIDKDELACQIPQNMTQ 1135 + L +I+ T ++ +QVN+SN+ Y +L + +A PL ILDV L+ C++N T ++ +PIIFW+ SY+ + N M+ N ++ ILPP+G S+++NWRR + + +D+S+ + ++Y LP F++EF LC E KN L+ E Q E V+ F I + IK+ D + + C G S C + + A+ ++Y +++ ++K +S +++LQ IY + L LC KV S+ +R+ + ++ L C IP++ Q Sbjct: 5 LLVLVIIIYTLTGKTQSKFPPTIQVNLSNVAYVKLEQISSKIFSAPPLVILDVVKLRNFTCFRNFYTMKYTLGIPIIFWNYSYLQKINNLKYLMTTDTNITTK---ILPPTGVSSFQINWRRPGKS--SEHMELDTSFQRSYLNYFLPMSHTFIVEFNEGNTSKQLCNEIKNSLITEPIQRQELVVNFKGIKTIEEKIPSINIKLSDFEIEPIL---SCRNGYDSNCYIYLNSAKTFSYLLAINVLKRMSKYNINLQMQIYSRALDELCGIKVIYSSISNQRVVGTAEVVNSQILVCSIPKHFIQ 301 The following BLAST results are available for this feature:
BLAST of Estrella vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Estrella vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Estrella vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 2
BLAST of Estrella vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Estrella vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Estrella vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Estrella vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Estrella vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30027919 ID=SMED30027919|Name=Estrella|organism=Schmidtea mediterranea sexual|type=transcript|length=1374bpback to top protein sequence of SMED30027919-orf-1 >SMED30027919-orf-1 ID=SMED30027919-orf-1|Name=SMED30027919-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=355bp MLRILAKIFTLGLILATCGAVSKLNRLNLVQVNISNIIYKQLMTTKDNVLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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