COMM domain-containing protein 4

Overview


Name	COMM domain-containing protein 4
Smed ID	SMED30027897
Length (bp)	1068

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of COMM domain-containing protein 4 (SMED30027897) t-SNE clustered cells

Violin plots show distribution of expression levels for COMM domain-containing protein 4 (SMED30027897) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of COMM domain-containing protein 4 (SMED30027897) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for COMM domain-containing protein 4 (SMED30027897) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027897

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30027897	h1SMcG0005990	Contig2611	GPL15192	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30027897	h1SMcG0005990	dd_Smed_v4_2501_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30027897	h1SMcG0005990	dd_Smed_v4_2501_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of COMM domain-containing protein 4 vs. Ensembl Human
Match: COMMD4 (COMM domain containing 4 [Source:HGNC Symbol;Acc:HGNC:26027])

HSP 1 Score: 105.916 bits (263), Expect = 1.764e-26
Identity = 66/211 (31.28%), Postives = 115/211 (54.50%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+   V W +            LS S +  + +P++ + +    A  +    + +++S   F +  +E+ +    M+SL 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAG-VGWRV---------DYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG 199

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Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+   V W +            LS S +  + +P++ + +    A  +    + +++S   F +  +E+ +    M+SL 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAG-VGWRV---------DYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG 199

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BLAST of COMM domain-containing protein 4 vs. Ensembl Human
Match: COMMD4 (COMM domain containing 4 [Source:HGNC Symbol;Acc:HGNC:26027])

HSP 1 Score: 102.064 bits (253), Expect = 5.079e-25
Identity = 63/189 (33.33%), Postives = 104/189 (55.03%), Query Frame = 2

Query:   77 KMKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMS 634
            + +F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+   V W +   + +     +L  S   P+     + +R   A A    + P+ MS
Sbjct:   27 RARFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAG-VGWRVDYTLSS-----SLLQSVEEPM-----VHLRLEVAAAPGTPAQPVAMS 202

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Human
Match: COMMD4 (COMM domain containing 4 [Source:HGNC Symbol;Acc:HGNC:26027])

HSP 1 Score: 98.5969 bits (244), Expect = 1.571e-24
Identity = 51/115 (44.35%), Postives = 76/115 (66.09%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADN 415
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY + 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEK 113

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Human
Match: COMMD4 (COMM domain containing 4 [Source:HGNC Symbol;Acc:HGNC:26027])

HSP 1 Score: 92.4337 bits (228), Expect = 9.289e-22
Identity = 58/208 (27.88%), Postives = 102/208 (49.04%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  L+K+   K+L L+++                       +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+   V W +            LS S +  + +P++ + +    A  +    + +++S   F +  +E+ +    M+SL 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKMYE-KILKLTAD--------------------AKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAG-VGWRV---------DYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG 177

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BLAST of COMM domain-containing protein 4 vs. Ensembl Celegans
Match: T28F2.2 (pep chromosome:WBcel235:I:3637353:3638819:1 gene:WBGene00020901.1 transcript:T28F2.2b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T28F2.2)

HSP 1 Score: 66.2402 bits (160), Expect = 8.990e-13
Identity = 40/119 (33.61%), Postives = 68/119 (57.14%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEI-VNLSKLSNIKVLSL---SSNLIKCILEK----DTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYAD 412
            MK+ F GD++CP WLL EI  N S L+ +K   L   +S+L+ C  +K    DT + I        + +N++  ++   ++++++ A YD   + L +E+ QLGLP EH +Q+ K Y +
Sbjct:    1 MKYHFLGDMECPSWLLEEICTNFSNLTVLKFKELCNRASHLVLCGHDKPILSDTSEGI--------NSVNNHTNLVLIGNWLLLKPAGYDCPSTDLEKEVVQLGLPPEHGIQLRKVYEN 111

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BLAST of COMM domain-containing protein 4 vs. Ensembl Celegans
Match: T28F2.2 (pep chromosome:WBcel235:I:3637575:3638768:1 gene:WBGene00020901.1 transcript:T28F2.2a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T28F2.2)

HSP 1 Score: 53.9138 bits (128), Expect = 1.426e-8
Identity = 35/111 (31.53%), Postives = 62/111 (55.86%), Query Frame = 2

Query:  104 LDCPDWLLLEI-VNLSKLSNIKVLSL---SSNLIKCILEK----DTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYAD 412
            ++CP WLL EI  N S L+ +K   L   +S+L+ C  +K    DT + I        + +N++  ++   ++++++ A YD   + L +E+ QLGLP EH +Q+ K Y +
Sbjct:    1 MECPSWLLEEICTNFSNLTVLKFKELCNRASHLVLCGHDKPILSDTSEGI--------NSVNNHTNLVLIGNWLLLKPAGYDCPSTDLEKEVVQLGLPPEHGIQLRKVYEN 103

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BLAST of COMM domain-containing protein 4 vs. Ensembl Fly
Match: CG34039 (gene:FBgn0054039 transcript:FBtr0301014)

HSP 1 Score: 88.5817 bits (218), Expect = 1.921e-20
Identity = 46/109 (42.20%), Postives = 70/109 (64.22%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLS--SNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVK 400
            MKF+FCG+ DCPDW+L EI+  S LSN+ + +L   S+L+   +  +T +   + KSL S   N+ K  +A ++FM+  AA+Y  + S   EEIQQLGLPK+H+  + +
Sbjct:    1 MKFRFCGEGDCPDWVLAEII--STLSNLSIENLEQLSDLVAQRICGETFEEAKI-KSLTSTLTNEGKTAVACINFMLTSAARYSCSESIFGEEIQQLGLPKDHAAAMCR 106

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BLAST of COMM domain-containing protein 4 vs. Ensembl Zebrafish
Match: commd4 (COMM domain containing 4 [Source:ZFIN;Acc:ZDB-GENE-060929-600])

HSP 1 Score: 102.834 bits (255), Expect = 1.404e-25
Identity = 56/141 (39.72%), Postives = 85/141 (60.28%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNI 493
            M+F+FCGDLDCPDW+L EI  L+++S++K+  L   ++K +L+ + ID   + K L SD   D  D KA +  L F++  AAK+D    +LS E+QQLGLPKEH+  + K Y D    +   L+  ++   R +  V W +
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLARISSVKMKLLCVQVVKDLLD-EGIDYDKVSK-LTSDAKFDSGDIKACIGVLSFILSSAAKHDVDSESLSSELQQLGLPKEHTTGLCKSYEDKHSALQEKLRESSLRLGR-LQTVNWRV 138

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BLAST of COMM domain-containing protein 4 vs. Ensembl Xenopus
Match: commd4 (COMM domain containing 4 [Source:NCBI gene;Acc:496531])

HSP 1 Score: 102.449 bits (254), Expect = 2.594e-25
Identity = 63/209 (30.14%), Postives = 119/209 (56.94%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSL 697
            M+F+FCGDLDCPDW+L EI  LS++S++K+  + + ++K +L  + ID   + K L SD   +  D KA +A L F++  AAK++ +  +LS E+QQLGLP+EH+  + + Y +    +   L+  ++  +R I+ + W +   + +   K           +PL+ + +    AG +   ++ ++ S +  L+  +E+ + ++ MN+L
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLSRISSVKLKLICAQVLKKLL-GEQIDYEKIIK-LTSDARFESGDIKATVAVLCFILSSAAKHNVSSDSLSSELQQLGLPREHAASLCRSYEEKQNALQETLRESSLRLTR-ISSLNWRVDQILSSSIVKQV--------NEPLVHLNLNVTDAGCNQPLTMTVSASKLRVLI--TELKQALEMMNAL 196

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Xenopus
Match: commd4 (COMM domain containing 4 [Source:NCBI gene;Acc:496531])

HSP 1 Score: 100.138 bits (248), Expect = 1.709e-24
Identity = 62/208 (29.81%), Postives = 118/208 (56.73%), Query Frame = 2

Query:   83 KFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSL 697
            +F+FCGDLDCPDW+L EI  LS++S++K+  + + ++K +L  + ID   + K L SD   +  D KA +A L F++  AAK++ +  +LS E+QQLGLP+EH+  + + Y +    +   L+  ++  +R I+ + W +   + +   K           +PL+ + +    AG +   ++ ++ S +  L+  +E+ + ++ MN+L
Sbjct:    3 RFRFCGDLDCPDWVLAEISTLSRISSVKLKLICAQVLKKLL-GEQIDYEKIIK-LTSDARFESGDIKATVAVLCFILSSAAKHNVSSDSLSSELQQLGLPREHAASLCRSYEEKQNALQETLRESSLRLTR-ISSLNWRVDQILSSSIVKQV--------NEPLVHLNLNVTDAGCNQPLTMTVSASKLRVLI--TELKQALEMMNAL 197

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Xenopus
Match: commd4 (COMM domain containing 4 [Source:NCBI gene;Acc:496531])

HSP 1 Score: 100.138 bits (248), Expect = 3.175e-24
Identity = 64/220 (29.09%), Postives = 123/220 (55.91%), Query Frame = 2

Query:   47 SYLFNYFYFRKMKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSL 697
            S + ++F     +F+FCGDLDCPDW+L EI  LS++S++K+  + + ++K +L  + ID   + K L SD   +  D KA +A L F++  AAK++ +  +LS E+QQLGLP+EH+  + + Y +    +   L+  ++  +R I+ + W +   + +   K           +PL+ + +    AG +   ++ ++ S +  L+  +E+ + ++ MN+L
Sbjct:   18 SLMLSFF----QRFRFCGDLDCPDWVLAEISTLSRISSVKLKLICAQVLKKLL-GEQIDYEKIIK-LTSDARFESGDIKATVAVLCFILSSAAKHNVSSDSLSSELQQLGLPREHAASLCRSYEEKQNALQETLRESSLRLTR-ISSLNWRVDQILSSSIVKQV--------NEPLVHLNLNVTDAGCNQPLTMTVSASKLRVLI--TELKQALEMMNAL 220

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BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
Match: Commd4 (COMM domain containing 4 [Source:MGI Symbol;Acc:MGI:1913449])

HSP 1 Score: 106.686 bits (265), Expect = 6.252e-27
Identity = 65/211 (30.81%), Postives = 117/211 (55.45%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+ + V W +            LS S +  + +P++ ++++   A  +    + +++S   F +  +E+ +    M +L 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPKEHATSLCRCYEEKQSPLQEHLRACSLRVNRLAS-VGWRV---------DYTLSSSLLHSVEEPMVHLQLQVVPAPGTQAQPVSMSLSADKFQVLLAELKQAQTMMTALG 199

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
Match: Commd4 (COMM domain containing 4 [Source:MGI Symbol;Acc:MGI:1913449])

HSP 1 Score: 89.7373 bits (221), Expect = 7.552e-21
Identity = 56/209 (26.79%), Postives = 103/209 (49.28%), Query Frame = 2

Query:   83 KFKFCGDLDCPDWLLLEIVNLSKLS--NIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            +F+FCGDLDCPDW+L EI  L+K+     K+L L+++                       +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+ + V W +            LS S +  + +P++ ++++   A  +    + +++S   F +  +E+ +    M +L 
Sbjct:    2 RFRFCGDLDCPDWVLAEISTLAKIGIDYEKILKLTAD--------------------AKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPKEHATSLCRCYEEKQSPLQEHLRACSLRVNRLAS-VGWRV---------DYTLSSSLLHSVEEPMVHLQLQVVPAPGTQAQPVSMSLSADKFQVLLAELKQAQTMMTALG 180

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
Match: Commd4 (COMM domain containing 4 [Source:MGI Symbol;Acc:MGI:1913449])

HSP 1 Score: 88.9669 bits (219), Expect = 8.866e-21
Identity = 54/157 (34.39%), Postives = 87/157 (55.41%), Query Frame = 2

Query:   83 KFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPK-----------------EHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNI 493
            +F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPK                 EH+  + +CY +    +   L+  ++  +R+ + V W +
Sbjct:    2 RFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPKVSTRHLSRAPSELRLPAEHATSLCRCYEEKQSPLQEHLRACSLRVNRLAS-VGWRV 155

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
Match: Commd4 (COMM domain containing 4 [Source:MGI Symbol;Acc:MGI:1913449])

HSP 1 Score: 71.2478 bits (173), Expect = 2.482e-15
Identity = 39/103 (37.86%), Postives = 56/103 (54.37%), Query Frame = 2

Query:   98 GDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCY 406
            GDLDCPDW+L EI  L+K+   K+L L+++                       +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY
Sbjct:    1 GDLDCPDWVLAEISTLAKIYE-KILKLTAD--------------------AKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPKEHATSLCRCY 82

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
Match: Commd4 (COMM domain containing 4 [Source:MGI Symbol;Acc:MGI:1913449])

HSP 1 Score: 70.0922 bits (170), Expect = 1.013e-14
Identity = 43/96 (44.79%), Postives = 62/96 (64.58%), Query Frame = 2

Query:   98 GDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPK 376
            GDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPK
Sbjct:    2 GDLDCPDWVLAEISTLAKISSVKLRLLCSQVLKELLGQ-GIDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPK 95

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BLAST of COMM domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q9CQ02|COMD4_MOUSE (COMM domain-containing protein 4 OS=Mus musculus OX=10090 GN=Commd4 PE=1 SV=1)

HSP 1 Score: 106.686 bits (265), Expect = 4.373e-26
Identity = 65/211 (30.81%), Postives = 117/211 (55.45%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+ + V W +            LS S +  + +P++ ++++   A  +    + +++S   F +  +E+ +    M +L 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDSDSLSSELQQLGLPKEHATSLCRCYEEKQSPLQEHLRACSLRVNRLAS-VGWRV---------DYTLSSSLLHSVEEPMVHLQLQVVPAPGTQAQPVSMSLSADKFQVLLAELKQAQTMMTALG 199

[Close]

BLAST of COMM domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q9H0A8|COMD4_HUMAN (COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1)

HSP 1 Score: 105.916 bits (263), Expect = 8.473e-26
Identity = 66/211 (31.28%), Postives = 115/211 (54.50%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L S ++K +L +  ID   + K L +D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R+   V W +            LS S +  + +P++ + +    A  +    + +++S   F +  +E+ +    M+SL 
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQG-IDYEKILK-LTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAG-VGWRV---------DYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG 199

[Close]

BLAST of COMM domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q5E9V6|COMD4_BOVIN (COMM domain-containing protein 4 OS=Bos taurus OX=9913 GN=COMMD4 PE=2 SV=2)

HSP 1 Score: 102.064 bits (253), Expect = 1.886e-24
Identity = 61/188 (32.45%), Postives = 101/188 (53.72%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMS 634
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L   ++K +L    ID   + K L  D   +  D KA +A L F++  AAK+     +LS E+QQLGLPKEH+  + +CY +    +   L+  ++  +R++  V W +   + +   +           +PL  + +R   A +    + P+ MS
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLAKISSVKLRLLCGQVLKDLL-GGGIDYEKILK-LTMDARFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSSLQARLRACSLRVNRLVG-VGWRVDYTLSSSLLRTV--------EEPL--VHLRLEVAASPGAPAQPVAMS 175

[Close]

BLAST of COMM domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q550I8|COMD4_DICDI (COMM domain-containing protein 4 OS=Dictyostelium discoideum OX=44689 GN=commd4 PE=4 SV=1)

HSP 1 Score: 63.1586 bits (152), Expect = 1.321e-10
Identity = 34/94 (36.17%), Postives = 57/94 (60.64%), Query Frame = 2

Query:  152 LSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDD--LNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKI 427
            ++NI++  L+  +I  +   + ID   ++K +      + D KA++AA+HF+I  + K D   STLS E+QQLGLPKEH   I + + ++ EK+
Sbjct:    1 MTNIRIKLLTVQVITSLASGENIDFEKVEKLVKDAGFVIGDIKALIAAIHFIIFNSVKNDVDESTLSTELQQLGLPKEHCDSISRAFREHKEKL 94

[Close]

BLAST of COMM domain-containing protein 4 vs. TrEMBL
Match: T1IZI0 (COMM domain-containing protein OS=Strigamia maritima OX=126957 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 2.318e-28
Identity = 74/173 (42.77%), Postives = 105/173 (60.69%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYR 589
            MKFKFCGDLDCPDW+L EI  LSKL+++KV  L S ++  +L   +ID   +QK L SD   D+   KA +AA+ ++I  A KY T   TLS E+QQLGLPKEHS  I K YADN+ K+   L   ++  S  ++ ++W +   I +      LSD      +PL+ ++++ R
Sbjct:    1 MKFKFCGDLDCPDWILAEITTLSKLTSVKVKLLCSQVLNDVL-GGSIDYEKVQK-LTSDAKLDIGGIKASIAAISYIITSAVKYSTEEHTLSNELQQLGLPKEHSTAICKVYADNYAKLQKELNNNSLRLS-YLDDLQWRLDYIISSSH----LSDVS----EPLLHLKMKVR 162

[Close]

BLAST of COMM domain-containing protein 4 vs. TrEMBL
Match: A0A0L8ID29 (COMM domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22021663mg PE=4 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 5.562e-28
Identity = 79/211 (37.44%), Postives = 117/211 (55.45%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISK---LMDKMNS 694
            MKF+FCGDLDCPDW+L EI  LSKL+++K+  L + +I  IL  + ID   + K + +D   D+ D KA +AAL+F+I  AAK D    TLS E+QQLGLPKEHS  + K Y DN  K    L+ +++  S  +N ++W +   I ++  K            P + I ++       N   +   MS   F +F +E+ +   +MD +NS
Sbjct:    1 MKFRFCGDLDCPDWVLAEINILSKLTSVKMRLLCAQVISSILTAN-IDYEKVAK-ITADAKFDIGDIKASIAALYFIIRSAAKCDVDSDTLSNELQQLGLPKEHSTPLCKLYGDNVTKFQEQLRKQSLRISH-MNSIQWRVDYVISSKSLKTVNK--------PNVQICLKVVNPDTGNSKPVVFNMSAEKFRVFLNELKQVDTIMDNLNS 200

[Close]

BLAST of COMM domain-containing protein 4 vs. TrEMBL
Match: Q6WRH8 (COMM domain-containing protein OS=Branchiostoma belcheri tsingtauense OX=155462 PE=2 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 6.471e-28
Identity = 76/211 (36.02%), Postives = 115/211 (54.50%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  LSKL+++K+  L   ++K +L + +ID   + K L +D   +  D KA +AAL F++  AAKY     +LS E+QQLGLPKEHS  + K YADN   +      +++  S+ +   +W +            LS S +  + +P++ + +R R     N T     M+   F LF SE+ +    M  LA
Sbjct:    1 MRFRFCGDLDCPDWVLAEISILSKLTSVKMKLLCVQVVKDLLGQ-SIDYDKVHK-LTADAKYEAGDVKASIAALSFILSSAAKYQVDGDSLSNELQQLGLPKEHSSSLCKTYADNLGNLQAQFMRQSLKLSQ-LESAEWRV---------DYILSSSELQEVQEPMVQLRLRVRNPDTGNVTPHSFNMTADKFRLFVSELKQAHQVMEGLA 199

[Close]

BLAST of COMM domain-containing protein 4 vs. TrEMBL
Match: S4TAL9 (COMM domain-containing protein 4 OS=Branchiostoma lanceolatum OX=7740 PE=2 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 7.413e-28
Identity = 76/211 (36.02%), Postives = 115/211 (54.50%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLA 700
            M+F+FCGDLDCPDW+L EI  LSKL+++K+  L   ++K +L + +ID   + K L +D   +  D KA +AAL F++  AAKY     +LS E+QQLGLPKEHS  + K YADN   +      +++  S+ +   +W +            LS S +  + +P++ + +R R     N      TM+   F LF SE+ +    M  LA
Sbjct:    1 MRFRFCGDLDCPDWVLAEISILSKLTSVKMKLLCVQVVKDLLGQ-SIDYDKVHK-LTADAKYEAGDVKASIAALSFILSSAAKYQVDGDSLSNELQQLGLPKEHSSSLCKTYADNLGNLQAQFMRQSLKLSQ-LESAEWRV---------DYILSSSELQEVQEPMVQLRLRVRNPDTGNVAPHSFTMTADKFRLFLSELKQAHQVMEGLA 199

[Close]

BLAST of COMM domain-containing protein 4 vs. TrEMBL
Match: A0A369SGH6 (COMM domain-containing protein 4 OS=Trichoplax sp. H2 OX=287889 GN=TrispH2_002932 PE=4 SV=1)

HSP 1 Score: 117.857 bits (294), Expect = 8.854e-28
Identity = 60/139 (43.17%), Postives = 86/139 (61.87%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKD-TIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNI 493
            MKFKFCGDLDCPDW+L EI NLSK+S++K+  L + +IKC+LE +   D +    +    DL+D K  +A  HF++  AAKY+     L  E+QQLGLPKEH+  + + Y DN EK+   L+  ++  S+      W +
Sbjct:    1 MKFKFCGDLDCPDWVLAEITNLSKMSSVKMKLLITQVIKCMLEGELNYDKVYKLTADAKFDLSDIKGSIATSHFILCNAAKYNMESDALCNELQQLGLPKEHATGLCRAYHDNVEKLRQVLQDTSLRLSK-FKSCDWRV 138

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Cavefish
Match: commd4 (COMM domain-containing protein 4 [Source:NCBI gene;Acc:103023069])

HSP 1 Score: 109.383 bits (272), Expect = 4.444e-28
Identity = 73/211 (34.60%), Postives = 119/211 (56.40%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRK-AGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSL 697
            M+F+FCGDLDCPDW+L EI  L+++S++K+  L   +IK +L++D ID   + K L SD   +  D KA +A L F++  AAK+D    +LS E+QQLGLPKEH+  + K Y D    +   LK  ++   R +  V W +            LS S +  + +P++ + ++ +     S+ETS+ +T+    F +  +E+ +    MN+L
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLARISSVKMKLLCVQVIKDLLDED-IDYEKVSK-LTSDAKFESGDIKASVAVLSFILSSAAKHDVDGESLSSELQQLGLPKEHTTGLCKSYEDKHAALQQKLKESSLRLGR-LEVVNWRV---------DYTLSSSELKEVNEPVVQLRLQSQNPESGSSETSV-VTVGAEKFRVLLTELKQAQAMMNAL 198

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Cavefish
Match: commd4 (COMM domain-containing protein 4 [Source:NCBI gene;Acc:103023069])

HSP 1 Score: 105.145 bits (261), Expect = 1.812e-26
Identity = 59/141 (41.84%), Postives = 87/141 (61.70%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNI 493
            M+F+FCGDLDCPDW+L EI  L+++S++K+  L   +IK +L++D ID   + K L SD   +  D KA +A L F++  AAK+D    +LS E+QQLGLPKEH+  + K Y D    +   LK  ++   R +  V W +
Sbjct:    1 MRFRFCGDLDCPDWVLAEISTLARISSVKMKLLCVQVIKDLLDED-IDYEKVSK-LTSDAKFESGDIKASVAVLSFILSSAAKHDVDGESLSSELQQLGLPKEHTTGLCKSYEDKHAALQQKLKESSLRLGR-LEVVNWRV 138

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Cavefish
Match: commd4 (COMM domain-containing protein 4 [Source:NCBI gene;Acc:103023069])

HSP 1 Score: 89.3521 bits (220), Expect = 6.406e-21
Identity = 64/206 (31.07%), Postives = 103/206 (50.00%), Query Frame = 2

Query:   86 FKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRK-AGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSL 697
            F+FCGDLDCPDW+L EI  L+++   KV  L+S+                     S D+   KA +A L F++  AAK+D    +LS E+QQLGLPKEH+  + K Y D    +   LK  ++   R +  V W +            LS S +  + +P++ + ++ +     S+ETS+ +T+    F +  +E+ +    MN+L
Sbjct:    2 FRFCGDLDCPDWVLAEISTLARIYE-KVSKLTSD-----------------AKFESGDI---KASVAVLSFILSSAAKHDVDGESLSSELQQLGLPKEHTTGLCKSYEDKHAALQQKLKESSLRLGR-LEVVNWRV---------DYTLSSSELKEVNEPVVQLRLQSQNPESGSSETSV-VTVGAEKFRVLLTELKQAQAMMNAL 175

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Nematostella
Match: EDO49332 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHE2])

HSP 1 Score: 110.923 bits (276), Expect = 4.415e-29
Identity = 61/141 (43.26%), Postives = 92/141 (65.25%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNI 493
            MKF+FCGDLDCPDW+L EI  LSK+S+IK+  L + ++K +L  +TID   +QK L SD   +++D KA++AAL F+++ AAKY     +L  E+QQLGLPKEH   + K YA++   +    +  ++    I N ++W +
Sbjct:    1 MKFRFCGDLDCPDWVLAEISTLSKMSSIKMKLLCAQVVKDLL-GETIDYAKVQK-LTSDAKFEVSDVKAVIAALCFILLSAAKYTVDSDSLGNELQQLGLPKEHCGALCKVYAESLSPLQDRFRETSLKFDGICN-LEWRV 138

[Close]

BLAST of COMM domain-containing protein 4 vs. Ensembl Medaka
Match: commd4 (COMM domain containing 4 [Source:NCBI gene;Acc:101165052])

HSP 1 Score: 108.997 bits (271), Expect = 6.969e-28
Identity = 70/210 (33.33%), Postives = 116/210 (55.24%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSD---DLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPL-DPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSL 697
            M+F+FCGDLDCPDW+L EI  L+K+S++K+  L   ++K +L  + ID   + K L +D   +  D KA +A L F++  AAK+D    +LS E+QQLGLPKEH+  + K Y D    +   L+  ++   R ++ V W +            LS S +  + +PLI ++++ + A +    +   ++S   F +  SE+ +    MN+L
Sbjct:    1 MRFRFCGDLDCPDWVLAEITTLAKMSSVKMKLLCGQVLKDLL-GEGIDYEKIVK-LTADAKFESGDIKASVAVLSFILSSAAKHDVDSESLSSELQQLGLPKEHASGLCKSYEDKHSALQDKLRETSLRLGR-LDSVSWRV---------DYTLSSSELSEVNEPLIHLKLQKQGAESGCSETAAFSISADKFRVLLSELKQAQALMNTL 198

[Close]

BLAST of COMM domain-containing protein 4 vs. Planmine SMEST
Match: SMESG000046681.1 (SMESG000046681.1)

HSP 1 Score: 413.69 bits (1062), Expect = 5.505e-147
Identity = 207/209 (99.04%), Postives = 208/209 (99.52%), Query Frame = 2

Query:   80 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLAKS 706
            MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKW+IKT IENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLAKS
Sbjct:    1 MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLISLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKEHSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWSIKTLIENRFAKIALSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLMDKMNSLAKS 209

The following BLAST results are available for this feature:

BLAST of COMM domain-containing protein 4 vs. Ensembl Human
BLAST of COMM domain-containing protein 4 vs. Ensembl Celegans
BLAST of COMM domain-containing protein 4 vs. Ensembl Fly
BLAST of COMM domain-containing protein 4 vs. Ensembl Zebrafish
BLAST of COMM domain-containing protein 4 vs. Ensembl Xenopus
BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
BLAST of COMM domain-containing protein 4 vs. UniProt/SwissProt
BLAST of COMM domain-containing protein 4 vs. TrEMBL
BLAST of COMM domain-containing protein 4 vs. Ensembl Cavefish
BLAST of COMM domain-containing protein 4 vs. Ensembl Sea Lamprey
BLAST of COMM domain-containing protein 4 vs. Ensembl Yeast
BLAST of COMM domain-containing protein 4 vs. Ensembl Nematostella
BLAST of COMM domain-containing protein 4 vs. Ensembl Medaka
BLAST of COMM domain-containing protein 4 vs. Planmine SMEST

BLAST of COMM domain-containing protein 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
COMMD4	1.764e-26	31.28	COMM domain containing 4 [Source:HGNC Symbol;Acc:H...	[more]
COMMD4	1.764e-26	31.28	COMM domain containing 4 [Source:HGNC Symbol;Acc:H...	[more]
COMMD4	5.079e-25	33.33	COMM domain containing 4 [Source:HGNC Symbol;Acc:H...	[more]
COMMD4	1.571e-24	44.35	COMM domain containing 4 [Source:HGNC Symbol;Acc:H...	[more]
COMMD4	9.289e-22	27.88	COMM domain containing 4 [Source:HGNC Symbol;Acc:H...	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
T28F2.2	8.990e-13	33.61	pep chromosome:WBcel235:I:3637353:3638819:1 gene:W...	[more]
T28F2.2	1.426e-8	31.53	pep chromosome:WBcel235:I:3637575:3638768:1 gene:W...	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CG34039	1.921e-20	42.20	gene:FBgn0054039 transcript:FBtr0301014	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
commd4	1.404e-25	39.72	COMM domain containing 4 [Source:ZFIN;Acc:ZDB-GENE...	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
commd4	2.594e-25	30.14	COMM domain containing 4 [Source:NCBI gene;Acc:496...	[more]
commd4	1.709e-24	29.81	COMM domain containing 4 [Source:NCBI gene;Acc:496...	[more]
commd4	3.175e-24	29.09	COMM domain containing 4 [Source:NCBI gene;Acc:496...	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Commd4	6.252e-27	30.81	COMM domain containing 4 [Source:MGI Symbol;Acc:MG...	[more]
Commd4	7.552e-21	26.79	COMM domain containing 4 [Source:MGI Symbol;Acc:MG...	[more]
Commd4	8.866e-21	34.39	COMM domain containing 4 [Source:MGI Symbol;Acc:MG...	[more]
Commd4	2.482e-15	37.86	COMM domain containing 4 [Source:MGI Symbol;Acc:MG...	[more]
Commd4	1.013e-14	44.79	COMM domain containing 4 [Source:MGI Symbol;Acc:MG...	[more]

BLAST of COMM domain-containing protein 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4


Match Name	E-value	Identity	Description
sp\|Q9CQ02\|COMD4_MOUSE	4.373e-26	30.81	COMM domain-containing protein 4 OS=Mus musculus O...	[more]
sp\|Q9H0A8\|COMD4_HUMAN	8.473e-26	31.28	COMM domain-containing protein 4 OS=Homo sapiens O...	[more]
sp\|Q5E9V6\|COMD4_BOVIN	1.886e-24	32.45	COMM domain-containing protein 4 OS=Bos taurus OX=...	[more]
sp\|Q550I8\|COMD4_DICDI	1.321e-10	36.17	COMM domain-containing protein 4 OS=Dictyostelium ...	[more]

BLAST of COMM domain-containing protein 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
T1IZI0	2.318e-28	42.77	COMM domain-containing protein OS=Strigamia mariti...	[more]
A0A0L8ID29	5.562e-28	37.44	COMM domain-containing protein OS=Octopus bimaculo...	[more]
Q6WRH8	6.471e-28	36.02	COMM domain-containing protein OS=Branchiostoma be...	[more]
S4TAL9	7.413e-28	36.02	COMM domain-containing protein 4 OS=Branchiostoma ...	[more]
A0A369SGH6	8.854e-28	43.17	COMM domain-containing protein 4 OS=Trichoplax sp....	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
commd4	4.444e-28	34.60	COMM domain-containing protein 4 [Source:NCBI gene...	[more]
commd4	1.812e-26	41.84	COMM domain-containing protein 4 [Source:NCBI gene...	[more]
commd4	6.406e-21	31.07	COMM domain-containing protein 4 [Source:NCBI gene...	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of COMM domain-containing protein 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of COMM domain-containing protein 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO49332	4.415e-29	43.26	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of COMM domain-containing protein 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
commd4	6.969e-28	33.33	COMM domain containing 4 [Source:NCBI gene;Acc:101...	[more]

BLAST of COMM domain-containing protein 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000046681.1	5.505e-147	99.04	SMESG000046681.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027897 ID=SMED30027897|Name=COMM domain-containing protein 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1068bp
ATTAACTCTTATTTATAGAATTTTGTATTCTATTCCTTAATAAATATCAT
ATTTATTTAATTATTTTTATTTCAGAAAAATGAAATTTAAATTTTGTGGT
GATTTAGACTGTCCTGATTGGCTTTTATTAGAAATAGTGAATCTTTCTAA
ATTGTCAAATATCAAAGTTTTAAGTCTATCTTCAAATTTAATAAAATGCA
TTTTGGAAAAAGATACTATCGATCTAATTAGTCTTCAAAAAAGTTTACCC
AGTGATGATTTAAATGACAATAAAGCTATTATGGCTGCTCTTCATTTTAT
GATAATACAAGCAGCAAAGTATGACACTGCACCTTCTACATTATCGGAAG
AAATTCAGCAATTGGGTTTGCCCAAAGAACATTCTGTACAAATTGTAAAG
TGTTACGCCGATAATTTTGAAAAGATTGTTCTATTTTTAAAAACCAAAAC
AATTATGAATAGTAGAATAATCAATCCTGTCAAATGGAACATCAAAACTC
CAATCGAAAATCGATTTGCCAAAATCGCATTATCTGATTCTCGAATATTC
CCTTTAGATCCCTTGATTTCAATTGAAATTAGATATCGAAAGGCTGGAGC
TAGCAATGAAACTAGTCTGCCTTTAACGATGAGTTACGTAGATTTCCTCT
TGTTTAAATCGGAAATCAGTAAGCTAATGGACAAAATGAATTCATTGGCA
AAGTCATAATAGTACTATAAGTTTTCATCACCTGAACTTTATAATTTTTG
AAAAAAAATCTAAAAAATATTTCACTTTAAATTTAAATGAAATTAATTGG
CTTTTAAATTATTGATTAATATACAAACCCTAGTAAAAAATTAAAAATTA
ATTTTATTAATGATTTATTGATTATATCTAACTCACTAGATTGTGAAAAT
TTATTACTCTGAACAAGTTAGAATCATATAATAAAATTTTTATCCAGCGT
GACAAGATACCCAACAAAAATAAGCAAATGTACTCAAGGTCATCTATGTT
CTTATGTAGGTGATACGACTCACACGAAACCAATTACTTGATTAATTCAA
AAAGTTTAGCGTGTAAGT

protein sequence of SMED30027897-orf-1

>SMED30027897-orf-1 ID=SMED30027897-orf-1|Name=SMED30027897-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=210bp
MKFKFCGDLDCPDWLLLEIVNLSKLSNIKVLSLSSNLIKCILEKDTIDLI
SLQKSLPSDDLNDNKAIMAALHFMIIQAAKYDTAPSTLSEEIQQLGLPKE
HSVQIVKCYADNFEKIVLFLKTKTIMNSRIINPVKWNIKTPIENRFAKIA
LSDSRIFPLDPLISIEIRYRKAGASNETSLPLTMSYVDFLLFKSEISKLM
DKMNSLAKS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR017920	COMM

Vocabulary: **molecular function**
Term	Definition
GO:0003674	molecular_function

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005737	cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PANTHER	PTHR16231	FAMILY NOT NAMED	coord: 1..204
None	No IPR available	PANTHER	PTHR16231:SF4	COMM DOMAIN-CONTAINING PROTEIN 4	coord: 1..204

Main menu

COMM domain-containing protein 4

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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