Guanylate cyclase

Overview
NameGuanylate cyclase
Smed IDSMED30027833
Length (bp)1204
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Guanylate cyclase (SMED30027833) t-SNE clustered cells

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30027833) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Guanylate cyclase (SMED30027833) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30027833) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027833

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30027833h1SMcG0005345 Contig8789uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30027833h1SMcG0005345 Contig8789newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30027833h1SMcG0005345 dd_Smed_v4_18878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30027833h1SMcG0005345 dd_Smed_v4_18878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30027833h1SMcG0005345 dd_Smed_v4_18878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30027833h1SMcG0005345 Contig11454newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30027833h1SMcG0005345 Contig11454uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30027833h1SMcG0005345 dd_Smed_v4_15400_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30027833h1SMcG0005345 dd_Smed_v4_15400_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30027833h1SMcG0005345 dd_Smed_v4_15400_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 3 cellSMED30027833h1SMcG0005345 dd_Smed_v4_15400_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944])

HSP 1 Score: 90.5077 bits (223), Expect = 6.807e-19
Identity = 54/99 (54.55%), Postives = 70/99 (70.71%), Query Frame = 2 
Query:  548 LDIISN--TLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            LD +S+    ++ ++   L  G+HTG V AGVVG+KMPRYCLFGDTVNTASRMES G+  KI +SS+T+  L     +Q+  RG VE+KGKG + TYWL
Sbjct:  938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
[Close]
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 88.9669 bits (219), Expect = 2.667e-18
Identity = 53/81 (65.43%), Postives = 60/81 (74.07%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  KI +SS T+  L     +++  RG VE+KGKG V TYWL
Sbjct:  971 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWL 1051
[Close]
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688])

HSP 1 Score: 80.1073 bits (196), Expect = 1.675e-15
Identity = 35/51 (68.63%), Postives = 41/51 (80.39%), Query Frame = 2 
Query:  593 YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSST 745
            ++  G+H+G   AGVVGIKMPRYCLFGDTVNTASRMESTG   +I +S ST
Sbjct:  918 WIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGST 968
[Close]
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691])

HSP 1 Score: 79.337 bits (194), Expect = 3.469e-15
Identity = 47/79 (59.49%), Postives = 57/79 (72.15%), Query Frame = 2 
Query:  605 GIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLM-MHNVYQIXXXXXXXXXXXXXXSTYWL 838
            G+H+G VVAGVVG+ MPRYCLFGDTVNTASRMESTG   +I +S ST   L  +   Y++  RG  E+KGKG   T+WL
Sbjct:  982 GLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
[Close]
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689])

HSP 1 Score: 78.9518 bits (193), Expect = 4.614e-15
Identity = 46/79 (58.23%), Postives = 57/79 (72.15%), Query Frame = 2 
Query:  605 GIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKL-MMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            G+H+G  VAGVVG+ MPRYCLFGDTVNTASRMESTG   +I ++ ST   L  + + YQ+  RG  E+KGKG   T+WL
Sbjct:  978 GLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056
[Close]
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 84.7297 bits (208), Expect = 2.675e-17
Identity = 50/86 (58.14%), Postives = 61/86 (70.93%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLD 853
            L  G+H+G+VVAGVVG KMPRYCLFGDTVNT+SRMES G   KI +S  T   LM    +++  RG VE+KGKG  +TYWL  + D
Sbjct: 1121 LRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1206
[Close]
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 84.3445 bits (207), Expect = 2.835e-17
Identity = 50/86 (58.14%), Postives = 61/86 (70.93%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLD 853
            L  G+H+G+VVAGVVG KMPRYCLFGDTVNT+SRMES G   KI +S  T   LM    +++  RG VE+KGKG  +TYWL  + D
Sbjct: 1180 LRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1265
[Close]
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 84.3445 bits (207), Expect = 3.049e-17
Identity = 50/86 (58.14%), Postives = 61/86 (70.93%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLD 853
            L  G+H+G+VVAGVVG KMPRYCLFGDTVNT+SRMES G   KI +S  T   LM    +++  RG VE+KGKG  +TYWL  + D
Sbjct: 1142 LRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRGYKD 1227
[Close]
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-23 (Receptor-type guanylate cyclase gcy-23 [Source:UniProtKB/Swiss-Prot;Acc:G5EEE9])

HSP 1 Score: 82.8037 bits (203), Expect = 1.039e-16
Identity = 53/87 (60.92%), Postives = 63/87 (72.41%), Query Frame = 2 
Query:  605 GIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMM-HNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQS 862
            GIHTGTV AGVVG+  PRYCLFGDTVN ASRMEST E +KIQ+S   +   +  ++ +QI  RG VE KGKG V++YWL   L KQS
Sbjct:  976 GIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSEFQITLRGTVEAKGKGPVTSYWL---LGKQS 1059
[Close]
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-27 (Receptor-type guanylate cyclase gcy-27 [Source:UniProtKB/Swiss-Prot;Acc:Q9XU42])

HSP 1 Score: 80.8777 bits (198), Expect = 3.041e-16
Identity = 54/114 (47.37%), Postives = 73/114 (64.04%), Query Frame = 2 
Query:  518 KIGPILLEIALDIISNTLNKDNNSSYLLA-GIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDK 856
            ++  + LEI    +S TL  D N    +  G H G + AGV+GIK PRYCLFGDTVN ASRM+S     +IQ S  T + L+  + Y++V+RG+V VKGKG V+ YWL +H+ K
Sbjct:  470 EVAEMSLEIRAISLSYTLENDKNYKLRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTSEITARMLLATHEYKLVKRGIVHVKGKGEVNCYWLNEHIHK 583
[Close]
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: Gyc88E (gene:FBgn0038295 transcript:FBtr0110961)

HSP 1 Score: 92.0485 bits (227), Expect = 1.046e-19
Identity = 57/117 (48.72%), Postives = 82/117 (70.09%), Query Frame = 2 
Query:  533 LLEIALDIISNTLNKDNNSS----YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGL 871
            + ++ALD++    +  + S+     +  G+H+G VVAG+VG+KMPRYCLFGDTVNTASRMEST    K+ IS ST  K+++   Y+I+ERG ++VKGKG + TYWLE+  ++  L L
Sbjct:  489 VCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST--KVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQL 603
[Close]
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: Gyc88E (gene:FBgn0038295 transcript:FBtr0306245)

HSP 1 Score: 92.0485 bits (227), Expect = 1.046e-19
Identity = 57/117 (48.72%), Postives = 82/117 (70.09%), Query Frame = 2 
Query:  533 LLEIALDIISNTLNKDNNSS----YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGL 871
            + ++ALD++    +  + S+     +  G+H+G VVAG+VG+KMPRYCLFGDTVNTASRMEST    K+ IS ST  K+++   Y+I+ERG ++VKGKG + TYWLE+  ++  L L
Sbjct:  489 VCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST--KVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQL 603
[Close]
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: Gyc88E (gene:FBgn0038295 transcript:FBtr0334926)

HSP 1 Score: 92.0485 bits (227), Expect = 1.102e-19
Identity = 57/117 (48.72%), Postives = 82/117 (70.09%), Query Frame = 2 
Query:  533 LLEIALDIISNTLNKDNNSS----YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGL 871
            + ++ALD++    +  + S+     +  G+H+G VVAG+VG+KMPRYCLFGDTVNTASRMEST    K+ IS ST  K+++   Y+I+ERG ++VKGKG + TYWLE+  ++  L L
Sbjct:  489 VCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST--KVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQL 603
[Close]
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG33958 (gene:FBgn0053958 transcript:FBtr0099994)

HSP 1 Score: 88.9669 bits (219), Expect = 9.793e-19
Identity = 50/79 (63.29%), Postives = 59/79 (74.68%), Query Frame = 2 
Query:  602 AGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
             G+HTG VVAG+VG KMPRYCLFGDTVNTASRMESTGE QKI I+      L     ++   RG+++VKGKG +STYWL
Sbjct:  591 CGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
[Close]
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151)

HSP 1 Score: 88.9669 bits (219), Expect = 1.204e-18
Identity = 58/117 (49.57%), Postives = 73/117 (62.39%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSH 946
            L  G+HTG  VAGVVG+KMPRYCLFGDTVNTASRMES GE  KI IS +T++ L     +    RG V +KGKG + TYWLE  + + +  L++  + +   R  L     S  QSH
Sbjct: 1048 LRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPN-SLISPSKLMLTRRSSLKQPQRS--QSH 1161
[Close]
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:ch211-215j19.12 (si:ch211-215j19.12 [Source:ZFIN;Acc:ZDB-GENE-141212-103])

HSP 1 Score: 94.3597 bits (233), Expect = 1.900e-22
Identity = 57/81 (70.37%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L AGIHTG  VAGVVG KMPRYCLFGDTVNTASRMEST   QKI  SS+T   LM  N Y++  RG VEVKGKG + TYWL
Sbjct:   97 LRAGIHTGPCVAGVVGYKMPRYCLFGDTVNTASRMESTSLPQKIHASSATYLALMKDNAYELQLRGEVEVKGKGKMDTYWL 177
[Close]
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: CABZ01078606.1 (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:100333871])

HSP 1 Score: 89.7373 bits (221), Expect = 3.783e-20
Identity = 62/128 (48.44%), Postives = 77/128 (60.16%), Query Frame = 2 
Query:  542 IALDIIS-----NTLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERER 910
            +ALD++S        ++      + AGIH+G VVAGVVG KMPRYCLFGDTVNTASRMEST E  KIQ SSS    L     Y +  RG+++VKGKG++ TYWLE    K         E+   E E+
Sbjct:   97 MALDLVSVCKTFRIPHRPQTQLQIRAGIHSGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSEALKIQCSSSAFYLLEEIGGYLLTCRGLLQVKGKGDMVTYWLEGKCSKDMKKPATQQESEKPEAEK 224
[Close]
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 93.2041 bits (230), Expect = 6.468e-20
Identity = 52/81 (64.20%), Postives = 62/81 (76.54%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES GE  KI +SS+T+  L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  729 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWL 809
[Close]
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 92.8189 bits (229), Expect = 9.043e-20
Identity = 52/81 (64.20%), Postives = 62/81 (76.54%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES GE  KI +SS+T+  L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  977 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWL 1057
[Close]
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 92.8189 bits (229), Expect = 9.215e-20
Identity = 52/81 (64.20%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNTASRMES GE  KI +S +T+  L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  978 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWL 1058
[Close]
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 90.1225 bits (222), Expect = 5.981e-19
Identity = 42/70 (60.00%), Postives = 52/70 (74.29%), Query Frame = 2 
Query:  572 NKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQI 781
            ++ N    L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  +I ISS+T++ L   + +Q+
Sbjct:  467 HRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQL 536
[Close]
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 90.1225 bits (222), Expect = 7.669e-19
Identity = 42/70 (60.00%), Postives = 52/70 (74.29%), Query Frame = 2 
Query:  572 NKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQI 781
            ++ N    L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  +I ISS+T++ L   + +Q+
Sbjct:  520 HRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQL 589
[Close]
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 90.1225 bits (222), Expect = 7.897e-19
Identity = 42/70 (60.00%), Postives = 52/70 (74.29%), Query Frame = 2 
Query:  572 NKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQI 781
            ++ N    L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  +I ISS+T++ L   + +Q+
Sbjct:  552 HRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQL 621
[Close]
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 90.1225 bits (222), Expect = 8.732e-19
Identity = 42/70 (60.00%), Postives = 52/70 (74.29%), Query Frame = 2 
Query:  572 NKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQI 781
            ++ N    L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  +I ISS+T++ L   + +Q+
Sbjct:  625 HRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQL 694
[Close]
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 89.7373 bits (221), Expect = 8.982e-19
Identity = 42/70 (60.00%), Postives = 52/70 (74.29%), Query Frame = 2 
Query:  572 NKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQI 781
            ++ N    L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  +I ISS+T++ L   + +Q+
Sbjct:  572 HRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQL 641
[Close]
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2d (guanylate cyclase 2d [Source:MGI Symbol;Acc:MGI:106030])

HSP 1 Score: 86.2705 bits (212), Expect = 1.690e-19
Identity = 55/105 (52.38%), Postives = 69/105 (65.71%), Query Frame = 2 
Query:  542 IALDIISNTLN-----KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLM-MHNVYQIXXXXXXXXXXXXXXSTYWL 838
            +ALDI+S   N       +    + AG+H+G  VAGVVG+ MPRYCLFGDTVNTASRMESTG   +I +S ST + L+ +   Y+I  RG  E+KGKG   TYWL
Sbjct:   55 LALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWL 159
[Close]
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 90.1225 bits (222), Expect = 4.664e-19
Identity = 54/99 (54.55%), Postives = 70/99 (70.71%), Query Frame = 2 
Query:  548 LDIISN--TLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            LD +S+    ++ ++   L  G+HTG V AGVVG+KMPRYCLFGDTVNTASRMES G+  KI +SS+T+  L     +Q+  RG VE+KGKG + TYWL
Sbjct:  504 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 602
[Close]
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 90.5077 bits (223), Expect = 4.846e-19
Identity = 54/99 (54.55%), Postives = 70/99 (70.71%), Query Frame = 2 
Query:  548 LDIISN--TLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            LD +S+    ++ ++   L  G+HTG V AGVVG+KMPRYCLFGDTVNTASRMES G+  KI +SS+T+  L     +Q+  RG VE+KGKG + TYWL
Sbjct:  938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
[Close]
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371])

HSP 1 Score: 88.9669 bits (219), Expect = 1.779e-18
Identity = 52/81 (64.20%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  +I +SS T+  L   + +++  RG VE+KGKG V TYWL
Sbjct:  967 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWL 1047
[Close]
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2d (guanylate cyclase 2d [Source:MGI Symbol;Acc:MGI:106030])

HSP 1 Score: 86.6557 bits (213), Expect = 9.327e-18
Identity = 55/105 (52.38%), Postives = 69/105 (65.71%), Query Frame = 2 
Query:  542 IALDIISNTLN-----KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLM-MHNVYQIXXXXXXXXXXXXXXSTYWL 838
            +ALDI+S   N       +    + AG+H+G  VAGVVG+ MPRYCLFGDTVNTASRMESTG   +I +S ST + L+ +   Y+I  RG  E+KGKG   TYWL
Sbjct:  958 LALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWL 1062
[Close]
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q8INF0|GCY8E_DROME (Soluble guanylate cyclase 88E OS=Drosophila melanogaster OX=7227 GN=Gyc88E PE=1 SV=4)

HSP 1 Score: 92.0485 bits (227), Expect = 1.048e-18
Identity = 57/117 (48.72%), Postives = 82/117 (70.09%), Query Frame = 2 
Query:  533 LLEIALDIISNTLNKDNNSS----YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGL 871
            + ++ALD++    +  + S+     +  G+H+G VVAG+VG+KMPRYCLFGDTVNTASRMEST    K+ IS ST  K+++   Y+I+ERG ++VKGKG + TYWLE+  ++  L L
Sbjct:  489 VCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST--KVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQL 603
[Close]
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P55202|ANPRB_ANGJA (Atrial natriuretic peptide receptor 2 OS=Anguilla japonica OX=7937 GN=npr2 PE=2 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 2.608e-18
Identity = 53/88 (60.23%), Postives = 64/88 (72.73%), Query Frame = 2 
Query:  575 KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            + N+   L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  KI +SS+T++ L     + +  RG VE+KGKG + TYWL
Sbjct:  953 RPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSATKEVLDEFGYFDLQLRGDVEMKGKGKMRTYWL 1040
[Close]
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P20594|ANPRB_HUMAN (Atrial natriuretic peptide receptor 2 OS=Homo sapiens OX=9606 GN=NPR2 PE=1 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 3.269e-18
Identity = 54/99 (54.55%), Postives = 70/99 (70.71%), Query Frame = 2 
Query:  548 LDIISN--TLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            LD +S+    ++ ++   L  G+HTG V AGVVG+KMPRYCLFGDTVNTASRMES G+  KI +SS+T+  L     +Q+  RG VE+KGKG + TYWL
Sbjct:  938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
[Close]
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q6VVW5|ANPRB_MOUSE (Atrial natriuretic peptide receptor 2 OS=Mus musculus OX=10090 GN=Npr2 PE=1 SV=2)

HSP 1 Score: 90.5077 bits (223), Expect = 3.390e-18
Identity = 54/99 (54.55%), Postives = 70/99 (70.71%), Query Frame = 2 
Query:  548 LDIISN--TLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            LD +S+    ++ ++   L  G+HTG V AGVVG+KMPRYCLFGDTVNTASRMES G+  KI +SS+T+  L     +Q+  RG VE+KGKG + TYWL
Sbjct:  938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
[Close]
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P46197|ANPRB_BOVIN (Atrial natriuretic peptide receptor 2 OS=Bos taurus OX=9913 GN=NPR2 PE=2 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 3.390e-18
Identity = 54/99 (54.55%), Postives = 70/99 (70.71%), Query Frame = 2 
Query:  548 LDIISN--TLNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            LD +S+    ++ ++   L  G+HTG V AGVVG+KMPRYCLFGDTVNTASRMES G+  KI +SS+T+  L     +Q+  RG VE+KGKG + TYWL
Sbjct:  938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
[Close]
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A504YPV2 (Putative Soluble guanylyl cyclase beta subunit OS=Fasciola gigantica OX=46835 GN=FGIG_07314 PE=4 SV=1)

HSP 1 Score: 108.227 bits (269), Expect = 1.998e-22
Identity = 66/154 (42.86%), Postives = 92/154 (59.74%), Query Frame = 2 
Query:  524 GPILLEIALDIISNTLN-KDNN-----SSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLD-KQSLGLLNYMETVTKERERLGDANMSTYQSH-GEYWH 961
             P + E+ALD++S+    KDN+     S  +  G+HTG+ VAGVVG+KMPRYCLFG+TV+TA  ME+T   Q+IQ+S ST  KL  + VY + E+G+V+ K    + TYWL    +             + KERE L D+N ++ QS  GE W 
Sbjct:  163 APFIAEMALDMVSSVQEVKDNSKDPPESLRIRVGLHTGSAVAGVVGVKMPRYCLFGNTVSTAEVMEATSSPQRIQVSQSTYDKLSEYGVYDLTEKGMVQCKDGATIQTYWLNGRPEVADCPKTAKLFAQLNKERELLADSNSTSNQSQTGEGWE 316
[Close]
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A419PV35 (Soluble guanylate cyclase 88E (Fragment) OS=Clonorchis sinensis OX=79923 GN=Gyc88E PE=4 SV=1)

HSP 1 Score: 106.686 bits (265), Expect = 1.995e-21
Identity = 63/153 (41.18%), Postives = 91/153 (59.48%), Query Frame = 2 
Query:  524 GPILLEIALDII--SNTLNKDNNSS----YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSH-GEYWH 961
             PI+ E+ +D+I  +N++  ++        +  G+HTGT VAGVVG+KMPRYCLFG +V T   ME T    + QIS +T+ KL+ +NVY I  +G V+ K    + TYWL   L+      LN +  +  ERERL D+N+S+ Q+  GE W 
Sbjct:  311 APIMAEMGIDMIQSANSIKDESKDPPEGIKIRVGLHTGTAVAGVVGVKMPRYCLFGSSVATVELMEQTSSPLRAQISEATRNKLIEYNVYDIEPKGSVKTKDGTIIETYWLNGKLEGVDSTELNKL--MESERERLADSNLSSNQTKVGEGWE 461
[Close]
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A183P6X6 (Guanylate cyclase domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS10112 PE=4 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 3.801e-21
Identity = 64/157 (40.76%), Postives = 93/157 (59.24%), Query Frame = 2 
Query:  524 GPILLEIALDIISNTLN-KDNN-----SSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHL----DKQSLGLLNYMETVTKERERLGDANM-STYQSHGEYWH 961
             P + E+ALD++ +    KD +     S  +  G+H+G  VAGVVG+KMPRYCLFG TV T+  ME T   Q+IQ+S    + L+ + VY + E+G VE+K  G + TYWL        D+++   L+ + T   ERER+ D+NM S++Q  GE W 
Sbjct:   14 APFIAEMALDMVESVQTVKDESKEPPESLRIRVGVHSGPAVAGVVGVKMPRYCLFGSTVTTSELMEQTSSPQRIQVSVKAYENLLKYGVYDLTEKGRVELKDGGTILTYWLNGRSNSSDDEKTAKFLDELNT---ERERIADSNMASSHQHSGESWE 167
[Close]
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A4S2LAU4 (Guanylate cyclase domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_008646 PE=4 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 5.810e-21
Identity = 65/154 (42.21%), Postives = 90/154 (58.44%), Query Frame = 2 
Query:  524 GPILLEIALDIISNTLNKDNNSS------YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDK-QSLGLLNYMETVTKERERLGDANMSTYQS-HGEYWH 961
             PI+ E+ +D+I +  +  + S        +  G+HTGT VAGVVG+KMPRYCLFG +V T   ME T    + QIS +T+ KL+ +NVY I  +G V+ K    + TYWL   L+   S  L   ME+   ERERL D+N+S+ Q+  GE W 
Sbjct:  474 APIMAEMGIDMIQSASSIKDESKNPPEGIKIRVGLHTGTAVAGVVGVKMPRYCLFGSSVATVELMEQTSSPLRAQISEATRNKLIEYNVYDIEPKGSVKTKDGTTIETYWLNGKLEGVDSTELTKLMES---ERERLADSNLSSNQTKFGEGWE 624
[Close]
BLAST of Guanylate cyclase vs. TrEMBL
Match: G7YQF8 (Guanylate cyclase soluble subunit beta OS=Clonorchis sinensis OX=79923 GN=CLF_107107 PE=4 SV=1)

HSP 1 Score: 105.916 bits (263), Expect = 7.882e-21
Identity = 63/153 (41.18%), Postives = 91/153 (59.48%), Query Frame = 2 
Query:  524 GPILLEIALDII--SNTLNKDNNSS----YLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSH-GEYWH 961
             PI+ E+ +D+I  +N++  ++        +  G+HTGT VAGVVG+KMPRYCLFG +V T   ME T    + QIS +T+ KL+ +NVY I  +G V+ K    + TYWL   L+      LN +  +  ERERL D+N+S+ Q+  GE W 
Sbjct:  474 APIMAEMGIDMIQSANSIKDESKDPPEGIKIRVGLHTGTAVAGVVGVKMPRYCLFGSSVATVELMEQTSSPLRAQISEATRNKLIEYNVYDIEPKGSVKTKDGTIIETYWLNGKLEGVDSTELNKL--MENERERLADSNLSSNQTKVGEGWE 624
[Close]
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 93.5893 bits (231), Expect = 4.036e-20
Identity = 52/81 (64.20%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  KI +S +T+  L   N +Q+  RG +E+KGKG + TYWL
Sbjct:  964 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWL 1044
[Close]
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 90.8929 bits (224), Expect = 3.569e-19
Identity = 51/81 (62.96%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES GE  KI +SS++   L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  984 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWL 1064
[Close]
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 90.8929 bits (224), Expect = 3.569e-19
Identity = 51/81 (62.96%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES GE  KI +SS++   L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  984 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWL 1064
[Close]
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 90.5077 bits (223), Expect = 3.887e-19
Identity = 51/81 (62.96%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES GE  KI +SS++   L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  942 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWL 1022
[Close]
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 90.5077 bits (223), Expect = 3.975e-19
Identity = 51/81 (62.96%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES GE  KI +SS++   L   N +Q+  RG VE+KGKG + TYWL
Sbjct:  980 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWL 1060
[Close]
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002650.1 (pep scaffold:Pmarinus_7.0:GL478983:4063:28109:1 gene:ENSPMAG00000002416.1 transcript:ENSPMAT00000002650.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 90.5077 bits (223), Expect = 4.816e-20
Identity = 55/80 (68.75%), Postives = 58/80 (72.50%), Query Frame = 2 
Query:  602 AGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLE 841
            AGIHTG VVAGVVG KMPRYCLFGDTVNTASRMEST E  KIQ S ST   L     Y +  RG V VKGKG + T+WLE
Sbjct:  416 AGIHTGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSEALKIQCSPSTSSILQQIGSYLLSCRGTVTVKGKGEMITWWLE 495
[Close]
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.1965 bits (217), Expect = 3.981e-19
Identity = 50/81 (61.73%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIHTG V AGVVG+KMPR+CLFGDTVNTASRMES GE  KI +S +T++ L     +++  RG VE+KGKG + TYWL
Sbjct:  737 LRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWL 817
[Close]
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 86.6557 bits (213), Expect = 9.651e-19
Identity = 48/81 (59.26%), Postives = 60/81 (74.07%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRME+ GE  +I +SS+T+  L  +  + +   G V++KGKG + TYWL
Sbjct:  420 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWL 500
[Close]
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: gucy1b2 (guanylate cyclase 1, soluble, beta 2 [Source:ZFIN;Acc:ZDB-GENE-130530-664])

HSP 1 Score: 78.9518 bits (193), Expect = 1.884e-16
Identity = 36/52 (69.23%), Postives = 42/52 (80.77%), Query Frame = 2 
Query:  602 AGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKL 757
             GIH+G V+AGVVG KMPRYCLFGDTVNTASRMES G   +I +S ST++ L
Sbjct:  281 VGIHSGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGLPGRIHLSPSTREAL 332
[Close]
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: gucy1b1 (guanylate cyclase 1 soluble subunit beta 1 [Source:ZFIN;Acc:ZDB-GENE-090313-160])

HSP 1 Score: 76.2554 bits (186), Expect = 2.121e-16
Identity = 36/78 (46.15%), Postives = 51/78 (65.38%), Query Frame = 2 
Query:  533 LLEIALDIISNT--LNKDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLM 760
            +  +ALD+I +   +  D  +  +  G+H+G VVAGV+G +MPRYCLFG+TVN  SR E+TG   KI +S  T + LM
Sbjct:  105 VCRLALDMIDSAGRVTVDGKAVQITIGVHSGEVVAGVIGQRMPRYCLFGNTVNLTSRTETTGRPGKINVSEDTYRCLM 182
[Close]
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO43095 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZH8])

HSP 1 Score: 91.2781 bits (225), Expect = 6.475e-20
Identity = 54/86 (62.79%), Postives = 64/86 (74.42%), Query Frame = 2 
Query:  581 NNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            N+   +  GIHTGTVVAGVVG+KMPRYCLFGDTVNTASRMESTG    I +S  TQK L   N Y + +RG +++KGKG + TYWL
Sbjct:  536 NDHLRIRIGIHTGTVVAGVVGLKMPRYCLFGDTVNTASRMESTGLAMAIHVSEDTQKFLAKAN-YALKQRGSMDIKGKGGMKTYWL 620
[Close]
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO45306 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSZ0])

HSP 1 Score: 86.2705 bits (212), Expect = 1.145e-19
Identity = 55/110 (50.00%), Postives = 72/110 (65.45%), Query Frame = 2 
Query:  515 NKIGPILLEIALDIISNTLNKDNNSSYLLA--GIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            ++IG + L++     + TL+       L+   GIHTG  V+GVVG KMPRYCLFGDTVNTASRM++TG  QK+ IS +T   L   N + +  RG +EVKGKG + TYWL
Sbjct:  100 DEIGRMSLDLVRLTETTTLDSVPKGKKLMVRVGIHTGPCVSGVVGYKMPRYCLFGDTVNTASRMQTTGIPQKVHISETTYDLLTKFNTFHMEYRGTLEVKGKGLMRTYWL 209
[Close]
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9])

HSP 1 Score: 88.9669 bits (219), Expect = 3.219e-19
Identity = 54/88 (61.36%), Postives = 62/88 (70.45%), Query Frame = 2 
Query:  575 KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            + N+   L  GIH+G+ VAGVVG KMPRYCLFGDTVNTASRMES GE  KI IS ST++ L     Y I +RG V +KGKG   TYWL
Sbjct:  427 RPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWL 514
[Close]
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34267 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPS8])

HSP 1 Score: 82.0333 bits (201), Expect = 1.895e-17
Identity = 38/54 (70.37%), Postives = 42/54 (77.78%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKL 757
            L  GIH+G VVAGVVG  MPRYCLFGDTVNTASRMES GE  +I IS  T++ L
Sbjct:  239 LRVGIHSGPVVAGVVGNTMPRYCLFGDTVNTASRMESNGEALRIHISEDTKRIL 292
[Close]
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80])

HSP 1 Score: 79.337 bits (194), Expect = 4.653e-16
Identity = 50/87 (57.47%), Postives = 57/87 (65.52%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDK 856
            L  G HTG VVAGVVG  M RYCLFGDTVNTASRMES GE  +I IS  T+  L     + +  RG V +KGKG V T+WL   +DK
Sbjct:  413 LRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWLVSTVDK 499
[Close]
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 94.7449 bits (234), Expect = 1.919e-20
Identity = 52/82 (63.41%), Postives = 65/82 (79.27%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLE 841
            L  G+H+G V AGVVG+KMPRYCLFGDTVNTASRMESTGE  KI +S +T++ L   N +Q+  RG +EVKGKG++ TYWL+
Sbjct:  967 LRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQ 1048
[Close]
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 94.3597 bits (233), Expect = 2.293e-20
Identity = 52/82 (63.41%), Postives = 65/82 (79.27%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLE 841
            L  G+H+G V AGVVG+KMPRYCLFGDTVNTASRMESTGE  KI +S +T++ L   N +Q+  RG +EVKGKG++ TYWL+
Sbjct:  908 LRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQ 989
[Close]
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799])

HSP 1 Score: 94.3597 bits (233), Expect = 2.529e-20
Identity = 51/88 (57.95%), Postives = 67/88 (76.14%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQ 859
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES+GE  KI +S++T+  L+  N +Q+  RG +++KGKG ++TYWL    D Q
Sbjct:  976 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESDSQ 1063
[Close]
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 90.8929 bits (224), Expect = 3.368e-19
Identity = 53/88 (60.23%), Postives = 64/88 (72.73%), Query Frame = 2 
Query:  575 KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            + N+   L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  KI +SS+T++ L     + +  RG VE+KGKG + TYWL
Sbjct:  906 RPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWL 993
[Close]
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 90.8929 bits (224), Expect = 3.527e-19
Identity = 53/88 (60.23%), Postives = 64/88 (72.73%), Query Frame = 2 
Query:  575 KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            + N+   L  GIHTG V AGVVG+KMPRYCLFGDTVNTASRMES GE  KI +SS+T++ L     + +  RG VE+KGKG + TYWL
Sbjct:  958 RPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWL 1045
[Close]
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000079311.1 (SMESG000079311.1)

HSP 1 Score: 265.388 bits (677), Expect = 1.925e-82
Identity = 168/194 (86.60%), Postives = 174/194 (89.69%), Query Frame = 2 
Query:  524 GPILLEIALDIISNTLNKDN-----NSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSHGEYWHEXXXXXXXXXXXXXXXXXXXKGNHSKDDTSSAKTFNLPNGCRI 1090
             P++ E+AL++I       N      S  +  GIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIVERGVVEVKGKGNVSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSHGEYWHELSLSRCSSVSVSHSRTGSHKGNHSKDDTSSAKTFNL NGCRI
Sbjct:  448 APLIAEMALEMIDKICTIKNPANEIESLKIRVGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIVERGVVEVKGKGNVSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSHGEYWHELSLSRCSSVSVSHSRTGSHKGNHSKDDTSSAKTFNLSNGCRI 641
[Close]
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000035922.1 (SMESG000035922.1)

HSP 1 Score: 112.849 bits (281), Expect = 9.234e-27
Identity = 69/150 (46.00%), Postives = 100/150 (66.67%), Query Frame = 2 
Query:  524 GPILLEIALDIISNT---LNKDNNSSYL--LAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSHGEYW 958
             P ++E++LD+I +    ++  ++S  L    GIHTG VVAGVVG+KMPRYCLFGDTVNTASRMES  E QKI IS +T+ K+     Y+I ERG +++KGKGN+ TYWL+ H  +    + + +  + +ER  + D+N++  Q  G+ W
Sbjct:  485 APFIIEMSLDMIKSIGFLMDPSDHSRSLQIRVGIHTGMVVAGVVGLKMPRYCLFGDTVNTASRMESNSEPQKIHISEATKAKVTDLQSYKISERGHIDIKGKGNIKTYWLDGHNLENPKAVASLITQLERERITISDSNLAGSQIKGDGW 634
[Close]
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000035922.1 (SMESG000035922.1)

HSP 1 Score: 112.849 bits (281), Expect = 1.016e-26
Identity = 69/150 (46.00%), Postives = 100/150 (66.67%), Query Frame = 2 
Query:  524 GPILLEIALDIISNT---LNKDNNSSYL--LAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSHGEYW 958
             P ++E++LD+I +    ++  ++S  L    GIHTG VVAGVVG+KMPRYCLFGDTVNTASRMES  E QKI IS +T+ K+     Y+I ERG +++KGKGN+ TYWL+ H  +    + + +  + +ER  + D+N++  Q  G+ W
Sbjct:  481 APFIIEMSLDMIKSIGFLMDPSDHSRSLQIRVGIHTGMVVAGVVGLKMPRYCLFGDTVNTASRMESNSEPQKIHISEATKAKVTDLQSYKISERGHIDIKGKGNIKTYWLDGHNLENPKAVASLITQLERERITISDSNLAGSQIKGDGW 630
[Close]
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000054505.1 (SMESG000054505.1)

HSP 1 Score: 83.5741 bits (205), Expect = 5.450e-19
Identity = 55/108 (50.93%), Postives = 70/108 (64.81%), Query Frame = 2 
Query:  533 LLEIALDIISNTLN-----KDNNSSYLLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWLE 841
            + E +L I+ +  N      ++    +  GIHTG+VVAGVVG KMPR+CLFGDTVNTASRMESTG   KIQ S      +  +N Y    RG +EVKGKG+ +TY+LE
Sbjct:   48 ICEFSLGIVESVRNIYRIPHNDKQIAVRIGIHTGSVVAGVVGNKMPRFCLFGDTVNTASRMESTGVAMKIQASEKAYILINEYNKYTFTCRGQIEVKGKGSQTTYFLE 155
[Close]
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000007014.1 (SMESG000007014.1)

HSP 1 Score: 88.1965 bits (217), Expect = 1.847e-18
Identity = 53/81 (65.43%), Postives = 61/81 (75.31%), Query Frame = 2 
Query:  596 LLAGIHTGTVVAGVVGIKMPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIXXXXXXXXXXXXXXSTYWL 838
            L  GIH+G V AGVVG+KMPRYCLFGDTVNT+SRMES+G   KI ISSST+  L   N + + ERG VE+KGKG   TYWL
Sbjct: 1038 LRIGIHSGAVCAGVVGLKMPRYCLFGDTVNTSSRMESSGLPLKIHISSSTKNLLCTFNTFIMTERGYVEMKGKGLQLTYWL 1118
The following BLAST results are available for this feature:
BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NPR26.807e-1954.55natriuretic peptide receptor 2 [Source:HGNC Symbol... [more]
NPR12.667e-1865.43natriuretic peptide receptor 1 [Source:HGNC Symbol... [more]
GUCY2C1.675e-1568.63guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:... [more]
GUCY2F3.469e-1559.49guanylate cyclase 2F, retinal [Source:HGNC Symbol;... [more]
GUCY2D4.614e-1558.23guanylate cyclase 2D, retinal [Source:HGNC Symbol;... [more]
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BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gcy-282.675e-1758.14Receptor-type guanylate cyclase gcy-28 [Source:Un... [more]
gcy-282.835e-1758.14Receptor-type guanylate cyclase gcy-28 [Source:Un... [more]
gcy-283.049e-1758.14Receptor-type guanylate cyclase gcy-28 [Source:Un... [more]
gcy-231.039e-1660.92Receptor-type guanylate cyclase gcy-23 [Source:Un... [more]
gcy-273.041e-1647.37Receptor-type guanylate cyclase gcy-27 [Source:Un... [more]
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BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Gyc88E1.046e-1948.72gene:FBgn0038295 transcript:FBtr0110961[more]
Gyc88E1.046e-1948.72gene:FBgn0038295 transcript:FBtr0306245[more]
Gyc88E1.102e-1948.72gene:FBgn0038295 transcript:FBtr0334926[more]
CG339589.793e-1963.29gene:FBgn0053958 transcript:FBtr0099994[more]
CG311831.204e-1849.57gene:FBgn0051183 transcript:FBtr0346151[more]
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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:ch211-215j19.121.900e-2270.37si:ch211-215j19.12 [Source:ZFIN;Acc:ZDB-GENE-14121... [more]
CABZ01078606.13.783e-2048.44atrial natriuretic peptide receptor 1-like [Source... [more]
npr1b6.468e-2064.20natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z... [more]
npr1b9.043e-2064.20natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z... [more]
npr1a9.215e-2064.20natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z... [more]
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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NPR25.981e-1960.00natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
NPR27.669e-1960.00natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
NPR27.897e-1960.00natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
NPR28.732e-1960.00natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
NPR28.982e-1960.00natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
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BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Gucy2d1.690e-1952.38guanylate cyclase 2d [Source:MGI Symbol;Acc:MGI:10... [more]
Npr24.664e-1954.55natriuretic peptide receptor 2 [Source:MGI Symbol;... [more]
Npr24.846e-1954.55natriuretic peptide receptor 2 [Source:MGI Symbol;... [more]
Npr11.779e-1864.20natriuretic peptide receptor 1 [Source:MGI Symbol;... [more]
Gucy2d9.327e-1852.38guanylate cyclase 2d [Source:MGI Symbol;Acc:MGI:10... [more]
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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8INF0|GCY8E_DROME1.048e-1848.72Soluble guanylate cyclase 88E OS=Drosophila melano... [more]
sp|P55202|ANPRB_ANGJA2.608e-1860.23Atrial natriuretic peptide receptor 2 OS=Anguilla ... [more]
sp|P20594|ANPRB_HUMAN3.269e-1854.55Atrial natriuretic peptide receptor 2 OS=Homo sapi... [more]
sp|Q6VVW5|ANPRB_MOUSE3.390e-1854.55Atrial natriuretic peptide receptor 2 OS=Mus muscu... [more]
sp|P46197|ANPRB_BOVIN3.390e-1854.55Atrial natriuretic peptide receptor 2 OS=Bos tauru... [more]
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BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A504YPV21.998e-2242.86Putative Soluble guanylyl cyclase beta subunit OS=... [more]
A0A419PV351.995e-2141.18Soluble guanylate cyclase 88E (Fragment) OS=Clonor... [more]
A0A183P6X63.801e-2140.76Guanylate cyclase domain-containing protein OS=Sch... [more]
A0A4S2LAU45.810e-2142.21Guanylate cyclase domain-containing protein OS=Opi... [more]
G7YQF87.882e-2141.18Guanylate cyclase soluble subunit beta OS=Clonorch... [more]
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BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
npr1a4.036e-2064.20natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z... [more]
npr1b3.569e-1962.96atrial natriuretic peptide receptor 1-like [Source... [more]
npr1b3.569e-1962.96atrial natriuretic peptide receptor 1-like [Source... [more]
npr1b3.887e-1962.96atrial natriuretic peptide receptor 1-like [Source... [more]
npr1b3.975e-1962.96atrial natriuretic peptide receptor 1-like [Source... [more]
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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000002650.14.816e-2068.75pep scaffold:Pmarinus_7.0:GL478983:4063:28109:1 ge... [more]
ENSPMAT00000006352.13.981e-1961.73pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 ... [more]
NPR19.651e-1959.26natriuretic peptide receptor 1 [Source:HGNC Symbol... [more]
gucy1b21.884e-1669.23guanylate cyclase 1, soluble, beta 2 [Source:ZFIN;... [more]
gucy1b12.121e-1646.15guanylate cyclase 1 soluble subunit beta 1 [Source... [more]
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BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO430956.475e-2062.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO453061.145e-1950.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO342753.219e-1961.36Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO342671.895e-1770.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO309854.653e-1657.47Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
olgc71.919e-2063.41membrane guanylyl cyclase [Source:NCBI gene;Acc:10... [more]
olgc72.293e-2063.41membrane guanylyl cyclase [Source:NCBI gene;Acc:10... [more]
olgc22.529e-2057.95membrane guanylyl cyclase [Source:NCBI gene;Acc:10... [more]
npr23.368e-1960.23natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
npr23.527e-1960.23natriuretic peptide receptor 2 [Source:NCBI gene;A... [more]
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BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000079311.11.925e-8286.60SMESG000079311.1[more]
SMESG000035922.19.234e-2746.00SMESG000035922.1[more]
SMESG000035922.11.016e-2646.00SMESG000035922.1[more]
SMESG000054505.15.450e-1950.93SMESG000054505.1[more]
SMESG000007014.11.847e-1865.43SMESG000007014.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027833 ID=SMED30027833|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=1204bp
TATATGTAAGAATGGATTTAGAGAAAATGGTTTCAAGTGACAAATATTGA
CGTTTTTGGAATTATTTCTAAAATCAACAACAAAAAAAAAGAAAAAAATC
GATTCTACCAGAAATATAAGTTAAATTTTGTATTTGAGTGAACAGGAACA
ATTTCAGGTGGAAAATGTTTCAATTAATAAAAACGACGGAAAAGAAATTT
ATTTATGTGTTTAAAAATGTAACAGATGAGCATTTTTACATTTTATGAAA
TATGTTTGGATAATTTTTGGTAGGGTCGGTCGTCTTTTTTTAAATTGAAA
TGATGATGGATTCTGATGGTTTCTAATTATGTCTTGACTCATTTGGTGAC
ACATAAATGATATGAGTTGATCATACGCTTAGTTCTTCAAGGTTTAAATA
CACAAAATACATTTATATTCAGCTGACATGAGTAACTCAATAATGTAGCT
TGTTGGCGGCGTAGTCAATCACAAAGTCACTGTATTTGACTACGGTGTAT
AGTGATGAAAGCTAAACAAAATTGGACCTATTCTACTAGAAATTGCATTG
GATATCATATCAAATACTTTAAATAAAGATAATAATTCAAGTTATTTACT
TGCAGGTATACATACTGGAACAGTTGTAGCAGGAGTCGTTGGAATCAAGA
TGCCTCGATATTGTTTATTTGGTGACACCGTTAATACAGCATCAAGAATG
GAGTCTACTGGCGAGACCCAGAAAATTCAGATTAGTTCCAGTACCCAAAA
GAAACTAATGATGCACAATGTTTATCAAATAGTTGAAAGAGGAGTGGTAG
AAGTGAAAGGTAAAGGTAATGTATCCACTTATTGGCTCGAAAAACACTTG
GACAAACAATCTCTAGGATTACTGAATTATATGGAAACTGTCACTAAGGA
AAGAGAGCGGTTAGGTGATGCAAATATGTCAACATATCAGAGTCATGGAG
AATATTGGCATGAATTATCCTTAAGTCGTTGTAGTTCAGTGTCTGTCAGT
CATTCTCGTACAGGATCTCACAAAGGAAACCATTCGAAAGATGATACCTC
TTCAGCAAAAACCTTCAATCTTCCAAATGGATGTCGTATTTGAATTGAAG
AAATTTATTAATTAAATCCGATTTCAATCTACTTGTGAATAATTTTGAAT
ATTTTTAACATTATTTAAAAATTATGATTTTTTAAAAATAAATGTGTCTC
TCAG
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protein sequence of SMED30027833-orf-1

>SMED30027833-orf-1 ID=SMED30027833-orf-1|Name=SMED30027833-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=148bp
MPRYCLFGDTVNTASRMESTGETQKIQISSSTQKKLMMHNVYQIVERGVV
EVKGKGNVSTYWLEKHLDKQSLGLLNYMETVTKERERLGDANMSTYQSHG
EYWHELSLSRCSSVSVSHSRTGSHKGNHSKDDTSSAKTFNLPNGCRI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000035Category 3 cell
Vocabulary: INTERPRO
TermDefinition
IPR001054A/G_cyclase
IPR018297A/G_cyclase_CS
IPR029787Nucleotide_cyclase
Vocabulary: biological process
TermDefinition
GO:0009190cyclic nucleotide biosynthetic process
GO:0035556intracellular signal transduction
GO:0006182cGMP biosynthetic process
GO:0006468protein phosphorylation
GO:0007165signal transduction
Vocabulary: molecular function
TermDefinition
GO:0016849phosphorus-oxygen lyase activity
GO:0000166nucleotide binding
GO:0004383guanylate cyclase activity
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0016829lyase activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0008074guanylate cyclase complex, soluble
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 147..147
NoneNo IPR availablePANTHERPTHR11920:SF335GUANYLATE CYCLASEcoord: 1..71
NoneNo IPR availablePANTHERPTHR11920ADENYLATE AND GUANYLATE CYCLASEScoord: 1..71
NoneNo IPR availableCDDcd07302CHDcoord: 1..63
e-value: 3.92913E-19
score: 76.849
IPR001054Adenylyl cyclase class-3/4/guanylyl cyclasePFAMPF00211Guanylate_cyccoord: 1..64
e-value: 4.5E-20
score: 72.0
IPR001054Adenylyl cyclase class-3/4/guanylyl cyclasePROSITEPS50125GUANYLATE_CYCLASE_2coord: 1..18
score: 11.482
IPR029787Nucleotide cyclaseGENE3DG3DSA:3.30.70.1230coord: 1..68
e-value: 1.3E-23
score: 85.5
IPR029787Nucleotide cyclaseSUPERFAMILYSSF55073Nucleotide cyclasecoord: 1..70