Uroporphyrinogen-III synthase

Overview
NameUroporphyrinogen-III synthase
Smed IDSMED30027802
Length (bp)1495
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Uroporphyrinogen-III synthase (SMED30027802) t-SNE clustered cells

Violin plots show distribution of expression levels for Uroporphyrinogen-III synthase (SMED30027802) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Uroporphyrinogen-III synthase (SMED30027802) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Uroporphyrinogen-III synthase (SMED30027802) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027802

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30027802SMESG000035357.1 dd_Smed_v4_4258_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30027802SMESG000035357.1 dd_Smed_v4_4258_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30027802SMESG000035357.1 dd_Smed_v4_4258_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Human
Match: UROS (uroporphyrinogen III synthase [Source:HGNC Symbol;Acc:HGNC:12592])

HSP 1 Score: 133.265 bits (334), Expect = 5.276e-35
Identity = 91/278 (32.73%), Postives = 137/278 (49.28%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQ--GDPYVKILQDNDFNVSLIETLDFVF-----------HPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMS------------GLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            M ++LLK  KE+    DPY++ L       +LI  L F F           HPE+              +  +IFTSPRAV+A ++              L  K N    +VVGNAT ++   +G +T G   GNA+ L + I + + +AL  PLLFPCG + R +LP  L++ GI ++S+ VY T     +   L   ++  Q +P  + FFSPSG+ +S K ++E      S     +IKF ++GP T+  L + G  V   + SP P+AL   I+
Sbjct:    1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPED--------------YGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYS-QQGVPASITFFSPSGLTYSLKHIQE-----LSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIR 256
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Human
Match: UROS (uroporphyrinogen III synthase [Source:HGNC Symbol;Acc:HGNC:12592])

HSP 1 Score: 133.265 bits (334), Expect = 5.276e-35
Identity = 91/278 (32.73%), Postives = 137/278 (49.28%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQ--GDPYVKILQDNDFNVSLIETLDFVF-----------HPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMS------------GLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            M ++LLK  KE+    DPY++ L       +LI  L F F           HPE+              +  +IFTSPRAV+A ++              L  K N    +VVGNAT ++   +G +T G   GNA+ L + I + + +AL  PLLFPCG + R +LP  L++ GI ++S+ VY T     +   L   ++  Q +P  + FFSPSG+ +S K ++E      S     +IKF ++GP T+  L + G  V   + SP P+AL   I+
Sbjct:    1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPED--------------YGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYS-QQGVPASITFFSPSGLTYSLKHIQE-----LSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIR 256
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Human
Match: UROS (uroporphyrinogen III synthase [Source:HGNC Symbol;Acc:HGNC:12592])

HSP 1 Score: 127.102 bits (318), Expect = 2.012e-32
Identity = 90/289 (31.14%), Postives = 143/289 (49.48%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQ--GDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMS------------GLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKE-------EIIS---KHSHLKCFRIK------------FGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            M ++LLK  KE+    DPY++ L       +LI  L F F    L +   + +   E +  +IFTSPRAV+A ++              L  K N    +VVGNAT ++   +G +T G   GNA+ L + I + + +AL  PLLFPCG + R +LP  L++ GI ++S+ VY T     +   L   ++  Q +P  + FFSPSG+ +S K ++E       +I +   +H    C +++            F ++GP T+  L + G  V   + SP P+AL   I+
Sbjct:    1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFL--SLPSF-SEKLSHPEDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYS-QQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKTQGPQHPKKNCLQLEPLRKDCTDTAVMFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIR 283
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Human
Match: UROS (uroporphyrinogen III synthase [Source:HGNC Symbol;Acc:HGNC:12592])

HSP 1 Score: 103.605 bits (257), Expect = 3.624e-25
Identity = 69/216 (31.94%), Postives = 107/216 (49.54%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQ--GDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM------------SGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKE 1025
            M ++LLK  KE+    DPY+++                  HPE+              +  +IFTSPRAV+A ++              L  K N    +VVGNAT ++   +G +T G   GNA+ L + I + + +AL  PLLFPCG + R +LP  L++ GI ++S+ VY T     +   L   ++  Q +P  + FFSPSG+ +S K ++E
Sbjct:    1 MKVLLLKDAKEDDCGQDPYIRL-----------------SHPED--------------YGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYS-QQGVPASITFFSPSGLTYSLKHIQE 182
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Human
Match: UROS (uroporphyrinogen III synthase [Source:HGNC Symbol;Acc:HGNC:12592])

HSP 1 Score: 89.7373 bits (221), Expect = 1.352e-20
Identity = 45/117 (38.46%), Postives = 71/117 (60.68%), Query Frame = 3 
Query:  675 FVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKE 1025
            +VVGNAT ++   +G +T G   GNA+ L + I + + +AL  PLLFPCG + R +LP  L++ GI ++S+ VY T     +   L   ++  Q +P  + FFSPSG+ +S K ++E
Sbjct:   25 YVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYS-QQGVPASITFFSPSGLTYSLKHIQE 138
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Fly
Match: Uros1 (gene:FBgn0030066 transcript:FBtr0333606)

HSP 1 Score: 98.9821 bits (245), Expect = 7.141e-23
Identity = 79/263 (30.04%), Postives = 125/263 (47.53%), Query Frame = 3 
Query:  411 TASNMHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVF-HPEELKAICGDTMRWDEYFSAIIFTSPRAVQA----FQMSGLPAKKNVIC-FVVGNATKAVAESL--GFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            T+    +++ K   E+  D Y + L+ +DFN   + TL F F + +EL+A     ++  + ++ IIFTSPR V+A      +  LP    ++  + VG  T  +A S      T G ++GNA  L D IV+    +   PLL PCG +    L +KL ENG  V +  VY T+   EL   ++          + L FFSPSG+  +++      +S        + K  ++GP+T   L S G  V   +  P  E L+K +
Sbjct:    2 TSRQRTVIIFKSESESS-DVYAETLEKHDFNPVFVPTLSFGFKNLDELRA----KLQNPDKYAGIIFTSPRCVEAVAESLNLGELPGGWKMLHNYAVGEVTHNLALSTLDQLFTHGKQTGNARALGDYIVDTFDGSRALPLLLPCGNLATDTLLSKLAENGFSVDACEVYETRCHPELGANVERALEIYGESIEFLAFFSPSGVNCAQQYFTSRQLSMD------KWKLVAIGPSTRRALESLGQKVYCTAERPTVEHLVKVL 253
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Fly
Match: Uros1 (gene:FBgn0030066 transcript:FBtr0071268)

HSP 1 Score: 98.9821 bits (245), Expect = 7.141e-23
Identity = 79/263 (30.04%), Postives = 125/263 (47.53%), Query Frame = 3 
Query:  411 TASNMHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVF-HPEELKAICGDTMRWDEYFSAIIFTSPRAVQA----FQMSGLPAKKNVIC-FVVGNATKAVAESL--GFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            T+    +++ K   E+  D Y + L+ +DFN   + TL F F + +EL+A     ++  + ++ IIFTSPR V+A      +  LP    ++  + VG  T  +A S      T G ++GNA  L D IV+    +   PLL PCG +    L +KL ENG  V +  VY T+   EL   ++          + L FFSPSG+  +++      +S        + K  ++GP+T   L S G  V   +  P  E L+K +
Sbjct:    2 TSRQRTVIIFKSESESS-DVYAETLEKHDFNPVFVPTLSFGFKNLDELRA----KLQNPDKYAGIIFTSPRCVEAVAESLNLGELPGGWKMLHNYAVGEVTHNLALSTLDQLFTHGKQTGNARALGDYIVDTFDGSRALPLLLPCGNLATDTLLSKLAENGFSVDACEVYETRCHPELGANVERALEIYGESIEFLAFFSPSGVNCAQQYFTSRQLSMD------KWKLVAIGPSTRRALESLGQKVYCTAERPTVEHLVKVL 253
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Fly
Match: Uros2 (gene:FBgn0038361 transcript:FBtr0083173)

HSP 1 Score: 48.521 bits (114), Expect = 5.908e-6
Identity = 56/203 (27.59%), Postives = 91/203 (44.83%), Query Frame = 3 
Query:  429 IVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQA----FQMSGLPA-KKNVICFVVGNATKAVAESLGFE---TAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLK--LLFTNNQNIPDLLIFFSPSGIAFS 1007
            ++LLK    +  D Y   L+ ++ +   I    FVF  + LK +        +Y + IIF SPR VQA       + LP+  + +  + +G  T + A  + F+   T G  + NA+ L D IV         PLL PCG      L  +L   G +V +  VY ++   +  ++++  L F   + I    +FF PS +  S
Sbjct:    9 VILLKVPSSD--DFYGSALRSHNLDPIFITPSHFVF--KNLKQLQAKLHEPHKY-AGIIFASPRCVQAVNEALGKTPLPSCWRALHNYSLGKNTHSAAW-ITFQNLPTLGDHAVNANNLCDLIVETFGPKRDLPLLMPCGNGVGQTLRLRLVAQGFRVDACEVYESRSHPDFVNQMRHALKFKRMETI----VFFGPSSVRSS 201
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Zebrafish
Match: uros (uroporphyrinogen III synthase [Source:ZFIN;Acc:ZDB-GENE-040323-2])

HSP 1 Score: 121.324 bits (303), Expect = 6.092e-31
Identity = 90/266 (33.83%), Postives = 131/266 (49.25%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQ--GDPYVKILQDNDFNVSLIETLDFVF-HPEELKAICGDTMRWDEYFSAIIFTSPRAVQAF-----------QMSGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            M ++LLK  +E++   DPY+K L       +LI  L F F    EL     + +   E F  +IFTSPRAV+A            Q   +  K N    +VVG AT ++   LG    G +SG AD L   I+  + N   +PL FPCG + R VLP  L  + I ++++ VY T E  +L   +   FT  Q +P  ++FFSPSG++F   +LK+      S  +  +IKF S+G  T+  L + G  V   +  P  + L  AI
Sbjct:    1 MKVLLLKEPRESESEADPYIKELASCGHTATLIPALSFRFVSLNEL----SERLFQPERFGGLIFTSPRAVEAVKTSLELQKLRHQWDAVKDKWNAKSVYVVGKATASLVVDLGLRPLGEDSGTADALALLILQRE-NPDIQPLFFPCGSIKREVLPTALRNSHIPLETLTVYQTSEHPDLQKNISDYFT-QQGVPACVVFFSPSGVSFCLDLLKD-----LSGCQLEQIKFASIGRTTADALQARGLTVSCCAEKPTAKHLAIAI 255
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Xenopus
Match: dync1i2 (dynein, cytoplasmic 1, intermediate chain 2 [Source:Xenbase;Acc:XB-GENE-960812])

HSP 1 Score: 127.872 bits (320), Expect = 3.888e-33
Identity = 89/267 (33.33%), Postives = 137/267 (51.31%), Query Frame = 3 
Query:  423 MHIVLLK--CVKENQGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMS-GLPAKKNV----IC--------FVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            M ++LLK    K+   DPYVK L       +LI  L F F    L     D +   E ++ +IFTSPRAV+A ++    P  K      +C        +VVG AT ++ E +G  + G  SGNA+ L + I +   +  + P+LFPCG + R VLP KL+E  + ++++ VY T     + D L   FT  + +P  ++FFSPSG+ +  K LK+       + +  +IKFG++GP T+  +   G  V   + +P P+ L   IK
Sbjct:    1 MKVLLLKDPKTKDLASDPYVKELSSYGLQATLIPVLSFKF--VSLDHFF-DKLSHPESYAGLIFTSPRAVEAVKLCLQTPDHKEAWNDRLCAKWNSKPVYVVGKATASLVEEIGLSSEGEGSGNAEKLAECICSKGLS-YSAPILFPCGSLKREVLPKKLQEKKVPLETITVYQTAPHPAVQDSLMNYFT-KEGVPASVVFFSPSGVKYCLKFLKD-----LPNDQLNQIKFGAIGPTTAEAMAEEGIPVSCTALNPTPQDLAIGIK 257
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Xenopus
Match: dync1i2 (dynein, cytoplasmic 1, intermediate chain 2 [Source:Xenbase;Acc:XB-GENE-960812])

HSP 1 Score: 115.931 bits (289), Expect = 1.025e-28
Identity = 71/211 (33.65%), Postives = 114/211 (54.03%), Query Frame = 3 
Query:  585 EYFSAIIFTSPRAVQAFQMS-GLPAKKNV----IC--------FVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            E ++ +IFTSPRAV+A ++    P  K      +C        +VVG AT ++ E +G  + G  SGNA+ L + I +    + + P+LFPCG + R VLP KL+E  + ++++ VY T     + D L   FT  + +P  ++FFSPSG+ +  K LK+       + +  +IKFG++GP T+  +   G  V   + +P P+ L   IK
Sbjct:   56 ESYAGLIFTSPRAVEAVKLCLQTPDHKEAWNDRLCAKWNSKPVYVVGKATASLVEEIGLSSEGEGSGNAEKLAECICSKGL-SYSAPILFPCGSLKREVLPKKLQEKKVPLETITVYQTAPHPAVQDSLMNYFT-KEGVPASVVFFSPSGVKYCLKFLKD-----LPNDQLNQIKFGAIGPTTAEAMAEEGIPVSCTALNPTPQDLAIGIK 259
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Mouse
Match: Uros (uroporphyrinogen III synthase [Source:MGI Symbol;Acc:MGI:98917])

HSP 1 Score: 124.405 bits (311), Expect = 6.392e-32
Identity = 89/270 (32.96%), Postives = 139/270 (51.48%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM------------SGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLI 1187
            M ++LLK  KE+    DPY++ L+      +LI  L F F    L ++  + +   E F  +IFTSPRAV+A ++              L  + N    +VVG+AT ++   +G +  GA SGNA+ L + I +   + L  PLLFPCG +    LP  L++ GI ++S+ VY T     +   LK  +  +Q IP  + FFSPSG+ +S      E I   S     +IKF ++GP+T+  + + G  V   + SP P+AL   I+ ++
Sbjct:    1 MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFM--SLPSL-SEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSEL--PLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYY-EDQGIPASITFFSPSGLKYS-----LEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVL 259
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Mouse
Match: Uros (uroporphyrinogen III synthase [Source:MGI Symbol;Acc:MGI:98917])

HSP 1 Score: 124.405 bits (311), Expect = 6.392e-32
Identity = 89/270 (32.96%), Postives = 139/270 (51.48%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM------------SGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLI 1187
            M ++LLK  KE+    DPY++ L+      +LI  L F F    L ++  + +   E F  +IFTSPRAV+A ++              L  + N    +VVG+AT ++   +G +  GA SGNA+ L + I +   + L  PLLFPCG +    LP  L++ GI ++S+ VY T     +   LK  +  +Q IP  + FFSPSG+ +S      E I   S     +IKF ++GP+T+  + + G  V   + SP P+AL   I+ ++
Sbjct:    1 MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFM--SLPSL-SEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSEL--PLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYY-EDQGIPASITFFSPSGLKYS-----LEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVL 259
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Mouse
Match: Uros (uroporphyrinogen III synthase [Source:MGI Symbol;Acc:MGI:98917])

HSP 1 Score: 124.405 bits (311), Expect = 6.392e-32
Identity = 89/270 (32.96%), Postives = 139/270 (51.48%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM------------SGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLI 1187
            M ++LLK  KE+    DPY++ L+      +LI  L F F    L ++  + +   E F  +IFTSPRAV+A ++              L  + N    +VVG+AT ++   +G +  GA SGNA+ L + I +   + L  PLLFPCG +    LP  L++ GI ++S+ VY T     +   LK  +  +Q IP  + FFSPSG+ +S      E I   S     +IKF ++GP+T+  + + G  V   + SP P+AL   I+ ++
Sbjct:    1 MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFM--SLPSL-SEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSEL--PLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYY-EDQGIPASITFFSPSGLKYS-----LEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVL 259
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Mouse
Match: Uros (uroporphyrinogen III synthase [Source:MGI Symbol;Acc:MGI:98917])

HSP 1 Score: 57.3806 bits (137), Expect = 3.874e-9
Identity = 43/134 (32.09%), Postives = 68/134 (50.75%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM------------SGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVN 779
            M ++LLK  KE+    DPY++ L+      +LI  L F F    L ++  + +   E F  +IFTSPRAV+A ++              L  + N    +VVG+AT ++   +G +  GA SGNA+ L + I +
Sbjct:    1 MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFM--SLPSL-SEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICS 131
[Close]
BLAST of Uroporphyrinogen-III synthase vs. UniProt/SwissProt
Match: sp|P10746|HEM4_HUMAN (Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1)

HSP 1 Score: 133.265 bits (334), Expect = 2.534e-34
Identity = 91/278 (32.73%), Postives = 137/278 (49.28%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQ--GDPYVKILQDNDFNVSLIETLDFVF-----------HPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMS------------GLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            M ++LLK  KE+    DPY++ L       +LI  L F F           HPE+              +  +IFTSPRAV+A ++              L  K N    +VVGNAT ++   +G +T G   GNA+ L + I + + +AL  PLLFPCG + R +LP  L++ GI ++S+ VY T     +   L   ++  Q +P  + FFSPSG+ +S K ++E      S     +IKF ++GP T+  L + G  V   + SP P+AL   I+
Sbjct:    1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPED--------------YGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYS-QQGVPASITFFSPSGLTYSLKHIQE-----LSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIR 256
[Close]
BLAST of Uroporphyrinogen-III synthase vs. UniProt/SwissProt
Match: sp|P51163|HEM4_MOUSE (Uroporphyrinogen-III synthase OS=Mus musculus OX=10090 GN=Uros PE=1 SV=1)

HSP 1 Score: 124.405 bits (311), Expect = 4.471e-31
Identity = 89/270 (32.96%), Postives = 139/270 (51.48%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM------------SGLPAKKNV-ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLI 1187
            M ++LLK  KE+    DPY++ L+      +LI  L F F    L ++  + +   E F  +IFTSPRAV+A ++              L  + N    +VVG+AT ++   +G +  GA SGNA+ L + I +   + L  PLLFPCG +    LP  L++ GI ++S+ VY T     +   LK  +  +Q IP  + FFSPSG+ +S      E I   S     +IKF ++GP+T+  + + G  V   + SP P+AL   I+ ++
Sbjct:    1 MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFM--SLPSL-SEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSEL--PLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYY-EDQGIPASITFFSPSGLKYS-----LEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVL 259
[Close]
BLAST of Uroporphyrinogen-III synthase vs. UniProt/SwissProt
Match: sp|P87214|HEM4_SCHPO (Uroporphyrinogen-III synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ups1 PE=3 SV=1)

HSP 1 Score: 80.8777 bits (198), Expect = 8.221e-16
Identity = 73/262 (27.86%), Postives = 114/262 (43.51%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDF-VFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQ----AFQMSGLPAKKNVI----CFVVGNATKAVAESLGFE-TAGAESGNADVLLDTIVN-YDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            M   LL   K    DPYV+  +    + + I  L     H E+L+    +  +    +  +I TS R  +    A +      ++ ++     F VG AT      LGF+ T G + G  +VL D I   Y      KPLLF  G+ HR ++  KL ++  +V S+IVY+T+E      ++K     +  I D ++ FSP+ I               S L  F +K  ++GP T   L   G    + S +P PE+L  +I
Sbjct:    1 MKTALLLKTKSQPFDPYVEAFEKYGRDTAFIPVLRHKRVHEEQLRDKLKNVRK---TYCGLIVTSQRVSETLDEALKQEDETERQKILMETPIFTVGPATDDSIRRLGFQQTHGKDCGRGEVLADLIEEWYTTTKQHKPLLFLVGEKHRDIIQRKLGDD--RVDSLIVYATQELENTETQIKDTIRKHPTI-DWIVAFSPTSIC--------------SLLNTFELKIATIGPTTGDYLKKLGTQPNVVSPAPNPESLASSI 242
[Close]
BLAST of Uroporphyrinogen-III synthase vs. UniProt/SwissProt
Match: sp|P06174|HEM4_YEAST (Uroporphyrinogen-III synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HEM4 PE=1 SV=2)

HSP 1 Score: 71.633 bits (174), Expect = 1.462e-12
Identity = 62/214 (28.97%), Postives = 95/214 (44.39%), Query Frame = 3 
Query:  600 IIFTSPRAVQAFQMSGLP--------AKKNVICFVVGNATKAVAESLGF--ETAGAESGNADVLLDTIVNYDRNALTKP-----LLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLF------TNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            II TS R V++   + +P        A  +   + VG AT       GF     G ++GN  +L D I++ D +   K      LLF  G++ R ++P KL   GI+V+ V+ Y T+   ELSD  K           ++   D ++ FSP G     + L +      SHL+       S+GP T   L       ++ S  P P++LL AI+
Sbjct:   65 IIITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNGSILADIIID-DLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTE---ELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNRLPGSHLRV-----ASIGPTTKKYLDDNDVTSDVVSPKPDPKSLLDAIE 269
[Close]
BLAST of Uroporphyrinogen-III synthase vs. TrEMBL
Match: A0A3R7GSH6 (Uroporphyrinogen-III synthase OS=Clonorchis sinensis OX=79923 GN=Uros PE=4 SV=1)

HSP 1 Score: 200.675 bits (509), Expect = 2.070e-57
Identity = 107/258 (41.47%), Postives = 155/258 (60.08%), Query Frame = 3 
Query:  423 MHIVLLKCVKEN----QGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGL 1184
            MHI+LLK + E       DPYV++L    F   L ETLDF +H  EL A C     W +  SAI+FTSPRAV A+  +GL  +++ +CFVVG +T   A+  GF   GA++G+A+ L   IV+   N LTKP+ FP  ++HR  LP  LE+NGI+V  +I YS+ E+  L D+++L       IPD ++FFSPSG+  +E +LK E+          ++K  +MG AT+++L     NV   + SP+PE+LL+ I+ L
Sbjct:    1 MHILLLKALNEQASGPHDDPYVQVLVKAGFTADLAETLDFTYHTAEL-ARC---QSWRDNHSAIVFTSPRAVTAYTKAGLKGQQSDLCFVVGPSTDVQAKKAGFSPKGAQAGDAETLSKVIVDNYANQLTKPVFFPASQIHRADLPQYLEKNGIKVDILIAYSSHENVALKDKVRLNLCEGNPIPDCIVFFSPSGVTLTESILKTELKPHRP-----KVKLVAMGRATASKLQEYDMNVAGVAASPRPESLLQVIQRL 249
[Close]
BLAST of Uroporphyrinogen-III synthase vs. TrEMBL
Match: G7YJZ8 (Uroporphyrinogen-III synthase OS=Clonorchis sinensis OX=79923 GN=CLF_109934 PE=4 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 6.160e-57
Identity = 107/258 (41.47%), Postives = 155/258 (60.08%), Query Frame = 3 
Query:  423 MHIVLLKCVKEN----QGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGL 1184
            MHI+LLK + E       DPYV++L    F   L ETLDF +H  EL A C     W +  SAI+FTSPRAV A+  +GL  +++ +CFVVG +T   A+  GF   GA++G+A+ L   IV+   N LTKP+ FP  ++HR  LP  LE+NGI+V  +I YS+ E+  L D+++L       IPD ++FFSPSG+  +E +LK E+          ++K  +MG AT+++L     NV   + SP+PE+LL+ I+ L
Sbjct:    1 MHILLLKALNEQASGPHDDPYVQVLVKAGFTADLAETLDFTYHTAEL-ARC---QSWRDNHSAIVFTSPRAVTAYTKAGLKGQQSDLCFVVGPSTDVQAKKAGFSPKGAQAGDAETLSKVIVDNYANQLTKPVFFPASQIHRADLPQYLEKNGIKVDILIAYSSHENVALKDKVRLNLCEGNPIPDCIVFFSPSGVTLTESILKTELKPHRP-----KVKLVAMGRATASKLQEYDMNVAGVAASPRPESLLQVIQRL 249
[Close]
BLAST of Uroporphyrinogen-III synthase vs. TrEMBL
Match: A0A4S2LP59 (HEM4 domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_005828 PE=4 SV=1)

HSP 1 Score: 199.134 bits (505), Expect = 9.654e-57
Identity = 106/258 (41.09%), Postives = 155/258 (60.08%), Query Frame = 3 
Query:  423 MHIVLLKCVKEN----QGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGL 1184
            MHI+LLK + E       DPYV++L    F+  L ETLDF +H  EL A C     W +  SAI+FTSPRAV A+  +GL  ++  +CFVVG +T   A+  GF   GA++G+A+ L   IV+   N LTKP+ FP  ++HR  LP  LE+NGI+V  +I YS+ E+  L D+++L       IPD ++FFSPSG+  +E +LK E+          ++K  +MG AT+++L     +V   + SP+PE+LL+ I+ L
Sbjct:    1 MHILLLKALNEQASGPHDDPYVQVLAKAGFSADLAETLDFTYHTAEL-ARC---QSWRDNHSAIVFTSPRAVTAYTKAGLKGQQADLCFVVGPSTDVQAKKAGFSPKGAQAGDAETLSKVIVDNYANQLTKPVFFPASQIHRADLPQYLEKNGIRVDIMIAYSSHENVALKDKVRLNLCEGNPIPDCIVFFSPSGVTLTESILKTELKPHRP-----KVKLVAMGRATASKLQEYDMSVAGVAASPRPESLLQVIQRL 249
[Close]
BLAST of Uroporphyrinogen-III synthase vs. TrEMBL
Match: A0A075ACM3 (HEM4 domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_12574 PE=4 SV=1)

HSP 1 Score: 195.667 bits (496), Expect = 1.767e-55
Identity = 105/258 (40.70%), Postives = 155/258 (60.08%), Query Frame = 3 
Query:  423 MHIVLLKCVKEN----QGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGL 1184
            MHI+LLK + E       DPYV++L    F+  L ETLDF +H  EL A C     W +  SAI+FTSPRAV A+  +GL  +++ +CFVVG +T   A+  GF   GA++G+A+ L   IV+     LTKP+ FP  ++HR  LP  LE+NGI+V  +I YS+ E+  L D+++L       IPD ++FFSPSG+  +E +LK E+          ++K  +MG AT+++L     +V   + SP+PE+LL+ I+ L
Sbjct:    1 MHILLLKALNEQASGPHDDPYVQVLVKAGFSADLAETLDFTYHTAEL-ARC---QSWRDNHSAIVFTSPRAVTAYTKAGLKGQQSDLCFVVGPSTDLQAKKAGFSPKGAQAGDAETLSKVIVDNYATQLTKPVFFPASQIHRADLPQYLEKNGIKVDILIAYSSHENVALKDKVRLNLCEGNPIPDCIVFFSPSGVTLTEGILKTELKPHRP-----KVKLVAMGRATASKLQEYDMSVAGVAASPRPESLLQVIQRL 249
[Close]
BLAST of Uroporphyrinogen-III synthase vs. TrEMBL
Match: A0A4E0RZD2 (Uroporphyrinogen-III synthase OS=Fasciola hepatica OX=6192 GN=D915_004517 PE=4 SV=1)

HSP 1 Score: 191.43 bits (485), Expect = 1.324e-53
Identity = 103/270 (38.15%), Postives = 152/270 (56.30%), Query Frame = 3 
Query:  423 MHIVLLKCVKEN----QGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEEN------------GIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGL 1184
            M+++LLK + E     + DPYV++L    F   LIETLDF++H + L A       W E   AI+FTSPR V AF  +GL  +   ICFVVG +T A+A+  GF   G+E G+ + L   I+    +A+TKP+ FP G+ HR  LP  LE              G++V +VIVYS +E  ++ ++L+L       IPD ++FFSPSG++ +E +LK E+          +I+  +MG +T A+L      V   ++SPKP++LL  IK L
Sbjct:    1 MYVLLLKSLSETASGPKDDPYVQVLNKAGFEADLIETLDFIYHTDRLAAY----QSWRESHGAIVFTSPRGVNAFTKAGLSGRSTDICFVVGPSTDALAKKAGFSPKGSECGDGETLAKFILTKHASAVTKPIFFPTGEQHRDELPRYLEAKGMCMFLPVINRPGMRVNTVIVYSAQEKEDMKEKLRLNLCEGHPIPDCVVFFSPSGVSLTETILKSEVKPHRP-----KIRLVAMGRSTEARLKEMELTVSGVAKSPKPDSLLAVIKTL 261
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Cavefish
Match: uros (uroporphyrinogen III synthase [Source:NCBI gene;Acc:103042014])

HSP 1 Score: 136.732 bits (343), Expect = 5.376e-36
Identity = 94/275 (34.18%), Postives = 138/275 (50.18%), Query Frame = 3 
Query:  393 SLSSLNTASNMHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM--------SGLPAKKNVI----CFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            S     T + M+++LLK  +E++   DPY+K L     + +LI  L F F       +  D +   E    +IFTSPRAV+A +M        S   A K+       +VVG AT ++ E LG  + G  SG ADVL   I+  +   + +PLLFPCG + R VLP  L +NGI ++++ VY T E  +L   +   F+  Q +P  + FFSPSG+ F    LK       +  K  +IK  ++GP T+  L + G  V   +  P P+ L K I
Sbjct:   44 SCCPYRTTAKMNVLLLKEPRESESGPDPYIKELALYGHSATLIPVLSFKFVSLN---VLSDKLFQPEKHGGLIFTSPRAVEAVKMCLESSSRRSEWDAVKDQWNRKSVYVVGKATASLVEDLGLTSCGENSGTADVLSRLIIEREGPEI-QPLLFPCGSLKREVLPTALRQNGIPLETLTVYQTSEHPDLEKNITHYFS-EQGVPASIAFFSPSGVKFCLNTLK-----GLAGTKLDKIKLAAVGPTTADALEAEGLRVGCTAEKPTPQHLAKGI 308
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Cavefish
Match: uros (uroporphyrinogen III synthase [Source:NCBI gene;Acc:103042014])

HSP 1 Score: 134.42 bits (337), Expect = 1.132e-35
Identity = 92/265 (34.72%), Postives = 135/265 (50.94%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQM--------SGLPAKKNVI----CFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            M+++LLK  +E++   DPY+K L     + +LI  L F F       +  D +   E    +IFTSPRAV+A +M        S   A K+       +VVG AT ++ E LG  + G  SG ADVL   I+  +   + +PLLFPCG + R VLP  L +NGI ++++ VY T E  +L   +   F+  Q +P  + FFSPSG+ F    LK       +  K  +IK  ++GP T+  L + G  V   +  P P+ L K I
Sbjct:    1 MNVLLLKEPRESESGPDPYIKELALYGHSATLIPVLSFKFVSLN---VLSDKLFQPEKHGGLIFTSPRAVEAVKMCLESSSRRSEWDAVKDQWNRKSVYVVGKATASLVEDLGLTSCGENSGTADVLSRLIIEREGPEI-QPLLFPCGSLKREVLPTALRQNGIPLETLTVYQTSEHPDLEKNITHYFS-EQGVPASIAFFSPSGVKFCLNTLK-----GLAGTKLDKIKLAAVGPTTADALEAEGLRVGCTAEKPTPQHLAKGI 255
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Yeast
Match: HEM4 (Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria [Source:SGD;Acc:S000005804])

HSP 1 Score: 71.633 bits (174), Expect = 2.105e-14
Identity = 62/214 (28.97%), Postives = 95/214 (44.39%), Query Frame = 3 
Query:  600 IIFTSPRAVQAFQMSGLP--------AKKNVICFVVGNATKAVAESLGF--ETAGAESGNADVLLDTIVNYDRNALTKP-----LLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLF------TNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIK 1178
            II TS R V++   + +P        A  +   + VG AT       GF     G ++GN  +L D I++ D +   K      LLF  G++ R ++P KL   GI+V+ V+ Y T+   ELSD  K           ++   D ++ FSP G     + L +      SHL+       S+GP T   L       ++ S  P P++LL AI+
Sbjct:   65 IIITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNGSILADIIID-DLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTE---ELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGDSNRLPGSHLRV-----ASIGPTTKKYLDDNDVTSDVVSPKPDPKSLLDAIE 269
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Nematostella
Match: EDO43184 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZ79])

HSP 1 Score: 95.1301 bits (235), Expect = 3.080e-22
Identity = 76/255 (29.80%), Postives = 121/255 (47.45%), Query Frame = 3 
Query:  429 IVLLKCVKEN-QGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMS-----GLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            ++LL+   ++ + D Y   L+ + F  + I  L F F  E L  +        EY   II TS R V+A +        L AKK                 LG E+ G ++G+A++L   I+    +  TKP LFPCG + +  +P +++  G+ +K + VY T + TEL+  L       + +P +++FFSPSG+ F   +L  EI    S LK   I     G  TSA +   G +V   ++ P P++L + I
Sbjct:    8 VLLLRSSSDDPKQDRYHMELRSHGFQCTSIPVLSFEF--ENLDKLEKMLSEPTEY-GGIILTSARGVEAMEKCIEEKISLSAKKK----------------LGLESVGHQAGSAEMLAPMILE-GAHPQTKPFLFPCGNLRKETIPTEMQNAGVPLKGLQVYKTCKHTELAQNLT-SHVEEKGVPSVIVFFSPSGVQFVLSLLT-EIFGDFSALKLVAI-----GATTSAAMIKHGLSVAAVAKQPSPKSLAECI 235
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Medaka
Match: uros (uroporphyrinogen III synthase [Source:NCBI gene;Acc:101165599])

HSP 1 Score: 103.99 bits (258), Expect = 4.797e-25
Identity = 86/267 (32.21%), Postives = 119/267 (44.57%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQG--DPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNV--------------ICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAI 1175
            MH++LLK  +E     DPY+K L  +    +LI  L F F    L  +  D +   E    +IFTSPRAV+A +M  L A+K                  +VVG AT A+ E                  DT +         P LFPCG + R VLP  L E G+ ++++ VY T E  +L   L   FT  Q  P  + FFSPSG+ F       E+I + S  +  +IKF ++GP T   + + G  V   +  P  E L   I
Sbjct:    1 MHVLLLKEPREEASGPDPYLKELASHGHKATLIPVLSFKF--VSLNTL-ADKLFQPEKHGGLIFTSPRAVEAVKMC-LDAEKRKEEWNKSLRDQWNTKPIYVVGKATAALGE------------------DTNI--------PPFLFPCGSIKREVLPTALREKGVPLETLTVYQTSEHPDLERNLNNFFT-EQGTPACVAFFSPSGVKFC-----LELILRLSGDQRTQIKFAAIGPTTRDAMAAEGLCVSCTAEKPTAEHLAAEI 231
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BLAST of Uroporphyrinogen-III synthase vs. Planmine SMEST
Match: SMESG000035357.1 (SMESG000035357.1)

HSP 1 Score: 526.939 bits (1356), Expect = 0.000e+0
Identity = 265/284 (93.31%), Postives = 265/284 (93.31%), Query Frame = 3 
Query:  387 MKSLSSLNTASNMHIVLLKCVKENQGDPYVK--------------ILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG 1196
            MKSLSSLNTASNMHIVLLKCVKENQGDPYVK              ILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHL     KFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG
Sbjct:    1 MKSLSSLNTASNMHIVLLKCVKENQGDPYVKVILIKLLFDEHLLQILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHL-----KFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG 279
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BLAST of Uroporphyrinogen-III synthase vs. Planmine SMEST
Match: SMESG000035357.1 (SMESG000035357.1)

HSP 1 Score: 513.072 bits (1320), Expect = 0.000e+0
Identity = 253/258 (98.06%), Postives = 253/258 (98.06%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG 1196
            MHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHL     KFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG
Sbjct:    1 MHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHL-----KFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG 253
[Close]
BLAST of Uroporphyrinogen-III synthase vs. Planmine SMEST
Match: SMESG000035357.1 (SMESG000035357.1)

HSP 1 Score: 503.827 bits (1296), Expect = 2.204e-179
Identity = 253/272 (93.01%), Postives = 253/272 (93.01%), Query Frame = 3 
Query:  423 MHIVLLKCVKENQGDPYVK--------------ILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG 1196
            MHIVLLKCVKENQGDPYVK              ILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHL     KFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG
Sbjct:    1 MHIVLLKCVKENQGDPYVKVILIKLLFDEHLLQILQDNDFNVSLIETLDFVFHPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVGNATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHRPVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFSPSGIAFSEKVLKEEIISKHSHL-----KFGSMGPATSAQLTSAGFNVELESRSPKPEALLKAIKGLIAVG 267
The following BLAST results are available for this feature:
BLAST of Uroporphyrinogen-III synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
UROS5.276e-3532.73uroporphyrinogen III synthase [Source:HGNC Symbol;... [more]
UROS5.276e-3532.73uroporphyrinogen III synthase [Source:HGNC Symbol;... [more]
UROS2.012e-3231.14uroporphyrinogen III synthase [Source:HGNC Symbol;... [more]
UROS3.624e-2531.94uroporphyrinogen III synthase [Source:HGNC Symbol;... [more]
UROS1.352e-2038.46uroporphyrinogen III synthase [Source:HGNC Symbol;... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Uros17.141e-2330.04gene:FBgn0030066 transcript:FBtr0333606[more]
Uros17.141e-2330.04gene:FBgn0030066 transcript:FBtr0071268[more]
Uros25.908e-627.59gene:FBgn0038361 transcript:FBtr0083173[more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
uros6.092e-3133.83uroporphyrinogen III synthase [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dync1i23.888e-3333.33dynein, cytoplasmic 1, intermediate chain 2 [Sourc... [more]
dync1i21.025e-2833.65dynein, cytoplasmic 1, intermediate chain 2 [Sourc... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Uros6.392e-3232.96uroporphyrinogen III synthase [Source:MGI Symbol;A... [more]
Uros6.392e-3232.96uroporphyrinogen III synthase [Source:MGI Symbol;A... [more]
Uros6.392e-3232.96uroporphyrinogen III synthase [Source:MGI Symbol;A... [more]
Uros3.874e-932.09uroporphyrinogen III synthase [Source:MGI Symbol;A... [more]
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BLAST of Uroporphyrinogen-III synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4
Match NameE-valueIdentityDescription
sp|P10746|HEM4_HUMAN2.534e-3432.73Uroporphyrinogen-III synthase OS=Homo sapiens OX=9... [more]
sp|P51163|HEM4_MOUSE4.471e-3132.96Uroporphyrinogen-III synthase OS=Mus musculus OX=1... [more]
sp|P87214|HEM4_SCHPO8.221e-1627.86Uroporphyrinogen-III synthase OS=Schizosaccharomyc... [more]
sp|P06174|HEM4_YEAST1.462e-1228.97Uroporphyrinogen-III synthase OS=Saccharomyces cer... [more]
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BLAST of Uroporphyrinogen-III synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3R7GSH62.070e-5741.47Uroporphyrinogen-III synthase OS=Clonorchis sinens... [more]
G7YJZ86.160e-5741.47Uroporphyrinogen-III synthase OS=Clonorchis sinens... [more]
A0A4S2LP599.654e-5741.09HEM4 domain-containing protein OS=Opisthorchis fel... [more]
A0A075ACM31.767e-5540.70HEM4 domain-containing protein OS=Opisthorchis viv... [more]
A0A4E0RZD21.324e-5338.15Uroporphyrinogen-III synthase OS=Fasciola hepatica... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
uros5.376e-3634.18uroporphyrinogen III synthase [Source:NCBI gene;Ac... [more]
uros1.132e-3534.72uroporphyrinogen III synthase [Source:NCBI gene;Ac... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HEM42.105e-1428.97Uroporphyrinogen III synthase; catalyzes the conve... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO431843.080e-2229.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
uros4.797e-2532.21uroporphyrinogen III synthase [Source:NCBI gene;Ac... [more]
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BLAST of Uroporphyrinogen-III synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000035357.10.000e+093.31SMESG000035357.1[more]
SMESG000035357.10.000e+098.06SMESG000035357.1[more]
SMESG000035357.12.204e-17993.01SMESG000035357.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027802 ID=SMED30027802|Name=Uroporphyrinogen-III synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=1495bp
TTAGATTTTGTAGACATTGTTATTCATCAATCAATTTCGTTAAATTTAAA
TCAATTCCTGAATTACAACCAAATTTTGTACTTAGTAAGTGTGTAATTTT
GAACGCACAAAAAATGACAAAGAAATCATTTTTTGTGCGTAATGACATTT
GTGTGCAATGAGTCATTCAATGCGTAAATCAGATCTAGATCTGTGTGTAT
ATTTAGTTACTACAAAGATACAGCATACAATGGTAATGACATTGTGTTGT
TCATCGACAAGTTTAATCATTTGTCACATTTAACTTAAAATTTGAAAATG
AATTGGTAAAAATTTAGCAGACTTTAAAAACCGGTTTTCGTTGAGATCTT
AGATATATTCATCTGAGATCACTGCGAAAGCTGATTATGAAGTCGCTTTC
TTCATTAAATACAGCGAGTAATATGCATATTGTTTTGTTGAAATGTGTAA
AAGAAAATCAGGGCGATCCTTACGTCAAAATTTTGCAAGATAATGATTTT
AATGTTTCTCTGATTGAAACATTAGATTTTGTATTTCATCCTGAAGAGTT
GAAAGCAATTTGTGGTGATACTATGAGATGGGATGAATATTTTAGTGCAA
TTATTTTTACTAGTCCTAGAGCAGTTCAAGCATTTCAGATGTCTGGTTTA
CCTGCTAAGAAAAACGTAATTTGTTTTGTGGTTGGTAATGCGACTAAAGC
TGTTGCAGAATCGCTTGGGTTTGAAACTGCTGGTGCAGAAAGTGGGAATG
CTGATGTTTTACTTGACACTATTGTTAATTATGACAGAAATGCTTTAACT
AAACCATTATTATTTCCATGTGGAAAAATGCATAGACCCGTTTTGCCAAA
CAAATTAGAGGAAAATGGAATCCAAGTCAAGTCTGTAATTGTTTATTCCA
CAAAAGAATCTACCGAATTATCAGATCGATTGAAACTTTTGTTTACGAAT
AATCAGAACATACCAGATTTGTTGATATTCTTCAGTCCGTCAGGAATCGC
ATTTTCTGAAAAAGTTTTGAAAGAGGAAATAATTTCGAAACATTCTCATT
TAAAATGCTTTCGAATTAAGTTTGGATCTATGGGCCCTGCGACAAGTGCC
CAGTTGACATCAGCTGGGTTTAATGTGGAACTGGAATCACGATCTCCAAA
GCCGGAGGCTTTATTAAAAGCAATCAAAGGTCTTATAGCTGTTGGATGAA
CCCGATTTGATTGTTAAGAACTGTATGTTATGCATGAGTGAGAGTCGCTG
TTCCTACCAGGCTATCGATTAGAGATTTTGGATGATAGATTTACAAGTTC
AAAATAATTTTGCTCATATCTTTGCTTATTAACCTAAACTGTGTTTTTAT
TGCTTTAAATTTCAAAATTGTGCCAATGCTTTGAAAATAGATTTTGCCCT
TTTATTTATTGATTTAGCATATCCGTTATTCGATCAAATAAGTATTCAGT
TTTCCGTTGTTTCTATTAATTTAAAGAAAAATGTTTGTTAAAAAA
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protein sequence of SMED30027802-orf-1

>SMED30027802-orf-1 ID=SMED30027802-orf-1|Name=SMED30027802-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=271bp
MKSLSSLNTASNMHIVLLKCVKENQGDPYVKILQDNDFNVSLIETLDFVF
HPEELKAICGDTMRWDEYFSAIIFTSPRAVQAFQMSGLPAKKNVICFVVG
NATKAVAESLGFETAGAESGNADVLLDTIVNYDRNALTKPLLFPCGKMHR
PVLPNKLEENGIQVKSVIVYSTKESTELSDRLKLLFTNNQNIPDLLIFFS
PSGIAFSEKVLKEEIISKHSHLKCFRIKFGSMGPATSAQLTSAGFNVELE
SRSPKPEALLKAIKGLIAVG*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006780uroporphyrinogen III biosynthetic process
GO:0033014tetrapyrrole biosynthetic process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000101muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR0361084pyrrol_syn_uPrphyn_synt_sf
IPR039793UROS/Hem4
IPR0037544pyrrol_synth_uPrphyn_synth
Vocabulary: molecular function
TermDefinition
GO:0004852uroporphyrinogen-III synthase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003754Tetrapyrrole biosynthesis, uroporphyrinogen III synthasePFAMPF02602HEM4coord: 29..260
e-value: 1.7E-34
score: 119.2
IPR003754Tetrapyrrole biosynthesis, uroporphyrinogen III synthaseCDDcd06578HemDcoord: 15..263
e-value: 1.80015E-43
score: 145.913
IPR036108Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamilyGENE3DG3DSA:3.40.50.10090coord: 46..177
e-value: 2.2E-53
score: 182.6
IPR036108Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamilyGENE3DG3DSA:3.40.50.10090coord: 27..260
e-value: 2.2E-53
score: 182.6
IPR036108Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamilySUPERFAMILYSSF69618HemD-likecoord: 21..265
IPR039793Uroporphyrinogen-III synthasePANTHERPTHR12390UROPORPHYRINOGEN III SYNTHASEcoord: 13..264