Niemann-Pick disease, type C1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30027726 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Human
Match: NPC1 (NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897]) HSP 1 Score: 929.472 bits (2401), Expect = 0.000e+0 Identity = 544/1277 (42.60%), Postives = 775/1277 (60.69%), Query Frame = 1
Query: 103 NDKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGY--------GGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDA-TSNAPFQINYL------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY------DKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARR--CLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFT----WINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKF-KEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRL-YPDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLG-NSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKK 3834
+ C+WYG+C + +K NC Y+GPPKPL G+ + +LCP + N SLCC+ QL TL L CP+C N + L+C LTC P Q F VT Y +++ + Y + ++F ++N+C +V S+N A+ +CG + C+ + + + + APF I + + ++ MN C+ + E CSCQDC C P P P +TILG+D I+ I + AF ++ + ++ + +Y D + + S D A E L F RWG F R C+I S+ I A S G++ +VTT+PV+LWS+PSS AR K+YFD++FGPF+RTEQ+II R P T + Y S ++ +GP +I +L +V L I N+ + N L+DIC PLSP C ++SV+ YFQN+ + LD D+F A Y + C++ P ++ T + C G FGGPVFP+L GG+ D +NY ++TALVITF VNN + ++++++ A WEK F+N V+N+ N +L IS+TAERS++DE++R+S++D+FT+ +SY IMF Y+++ LG + +++ VDSKV+LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FILVQ YQR DE + L +Q++ RV+ +V PSM LSS SE++AFF G ++ MPAV FSL+A AV DFLLQIT +++L LD KR E R+D+ CCVR T V A L F Y+P+L K +R +V+ FVG F+++ ++ + + L+Q LSMP DSYM++YF +++ YL GPPVYF++++G++Y S QNM+CG GCN SL+ Q+F A+Q N T I + +SW+DD+F W K + CCR+ FC ASVV+ C C P K RP F +L FL++NP+ +C KGGHAAY AVNI H +GATYFMTYHT+L+T +D+ +ALK + IA++VTE T+G N + + V PYSVFYVFYEQYLT+ LGV LG + LVT VLLG + + +I+ I +++ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HI RA+ V +R+ERA E L MGSSV SGITLTK GGI+VLAF+KSQ+FQIFYFRMYL +V+ GA H +IFLPV LS+ GP++N+ K
Sbjct: 22 SQSCVWYGECGIAYGDKRYNCEYSGPPKPLPK-DGYDLVQELCPGF--FFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTA-PCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITA--CSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLII----RAPLTDKHIYQPYP-SGADVPFGPPLDIQILHQVLDLQIAIENIT--ASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDF-FVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY-DDQNYNNATALVITFPVNNYYN-DTEKLQRAQAWEKEFINFVKNYK--NPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQR-DERLQGETL--DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQAS-------ESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSS--CCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL----LGHG-TRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTE----TMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 1259
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Human
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7898]) HSP 1 Score: 726.857 bits (1875), Expect = 0.000e+0 Identity = 482/1318 (36.57%), Postives = 730/1318 (55.39%), Query Frame = 1
Query: 112 CIWYGQCDKSNPN--------KILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV----DTGYGGSIQAVTYNLNENFYQGLF-----NSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYL---------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEK---CAVMSVMQYFQNNITQLDRIVTDEFNLPIAT----YMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDL-HISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPASVVNSTC-NNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKM--------PENNSWGN*NSDNIYI 3915
C +Y +C K NP ++C P + + L K+CP+ N CC+ QL++L+ LS + CP C NF+ L+C TC PNQ F+ V G G V Y E FYQ F +SC V + +A + A+ T+CG C+ + GD + AP I + + ++ +N+ + CN + G DD CSCQDC ASCPA PQ TF + + G + ++ I+ F ++ I + F + +D + P S DK L +F WG +VA L +L + +I + L+ G++ ++TTDPVELWS+P+S AR K + D++FGPF+RT Q+I+ +R+ + + + + +N + + ++DLL + L + +++V+S L+DIC+ PL+PD C + S++QYFQNN T L ++T L T + D + C P K T C D+G PVFP+LA GG+ K+Y+++ AL++TF +NN + + +A L WE+AFL ++ F + +++ AERS++DEI+R + DL A SYI++F Y+++ LG Y++ ++ VDSK TLGL V +VL +V ++GF+SYL + +L+IL+VVPFLVL+VG DN+FI V YQR E I R + +V PSMLL SLSE++ FF G +T MPAV+ F+L + AV+ DFLLQ++ +A+L LD+KR EA R+DV CCV+ + P G+L F K YAP L R +V++ F+ +L + I V L+Q+L++PKDSY+++YF L Y VG PVYF+ GYN+ SE N IC ++GCN S ++ A++ P +Y++ +SW+DDF W S CCRLY G FCP++V + C NC + RP + F YL +FL + P+++CPKGG AAY +VN+ + ++ A+ FM YH LK DYTEAL+ + E+AA++T L+ G FEV PY++ VFYEQYLT+ + L +CL V+ +LLGLD ++ L+ I++I+ GFM LWGI NA+S++NLV A+G+SVEF++HI R++ + T +ERA+E + MGS+V +G+ +T L GI+VL +K+QL QIF+FR+ L I + G H ++FLPV LS+ GP +N +EQK+ E + P + S + +DNIY+
Sbjct: 33 CAFYDECGK-NPELSGSLMTLSNVSCLSNTPARKIT-GDHLILLQKICPRLYT-GPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAY---EAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQG-DDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGF----RVAPARDKSKMVDPK----KGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKN--FSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLL--LLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGY-KGKDYSEAEALIMTFSLNNYPAGDPRLAQAKL-WEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR---EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG--------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSS---CCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDG-------QVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVS-TADNIYV 1307
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Human
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7898]) HSP 1 Score: 718.383 bits (1853), Expect = 0.000e+0 Identity = 484/1339 (36.15%), Postives = 731/1339 (54.59%), Query Frame = 1
Query: 112 CIWYGQCDKSNPN--------KILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV----DTGYGGSIQAVTYNLNENFYQGLF-----NSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYL---------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEK---CAVMSVMQYFQNNITQLDRIVTDEFNLPIAT----YMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDL-HISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPASVVNSTC-NNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEI---------------------GATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKM--------PENNSWGN*NSDNIYI 3915
C +Y +C K NP ++C P + + L K+CP+ N CC+ QL++L+ LS + CP C NF+ L+C TC PNQ F+ V G G V Y E FYQ F +SC V + +A + A+ T+CG C+ + GD + AP I + + ++ +N+ + CN + G DD CSCQDC ASCPA PQ TF + + G + ++ I+ F ++ I + F + +D + P S DK L +F WG +VA L +L + +I + L+ G++ ++TTDPVELWS+P+S AR K + D++FGPF+RT Q+I+ +R+ + + + + +N + + ++DLL + L + +++V+S L+DIC+ PL+PD C + S++QYFQNN T L ++T L T + D + C P K T C D+G PVFP+LA GG+ K+Y+++ AL++TF +NN + + +A L WE+AFL ++ F + +++ AERS++DEI+R + DL A SYI++F Y+++ LG Y++ ++ VDSK TLGL V +VL +V ++GF+SYL + +L+IL+VVPFLVL+VG DN+FI V YQR E I R + +V PSMLL SLSE++ FF G +T MPAV+ F+L + AV+ DFLLQ++ +A+L LD+KR EA R+DV CCV+ + P G+L F K YAP L R +V++ F+ +L + I V L+Q+L++PKDSY+++YF L Y VG PVYF+ GYN+ SE N IC ++GCN S ++ A++ P +Y++ +SW+DDF W S CCRLY G FCP++V + C NC + RP + F YL +FL + P+++CPKGG AAY +VN+ + D + V I + FM YH LK DYTEAL+ + E+AA++T L+ G FEV PY++ VFYEQYLT+ + L +CL V+ +LLGLD ++ L+ I++I+ GFM LWGI NA+S++NLV A+G+SVEF++HI R++ + T +ERA+E + MGS+V +G+ +T L GI+VL +K+QL QIF+FR+ L I + G H ++FLPV LS+ GP +N +EQK+ E + P + S + +DNIY+
Sbjct: 33 CAFYDECGK-NPELSGSLMTLSNVSCLSNTPARKIT-GDHLILLQKICPRLYT-GPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAY---EAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQG-DDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGF----RVAPARDKSKMVDPK----KGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKN--FSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLL--LLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGY-KGKDYSEAEALIMTFSLNNYPAGDPRLAQAKL-WEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR---EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG--------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSS---CCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTS-DGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVS-TADNIYV 1334
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Human
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7898]) HSP 1 Score: 683.33 bits (1762), Expect = 0.000e+0 Identity = 466/1318 (35.36%), Postives = 702/1318 (53.26%), Query Frame = 1
Query: 112 CIWYGQCDKSNPN--------KILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV----DTGYGGSIQAVTYNLNENFYQGLF-----NSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYL---------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEK---CAVMSVMQYFQNNITQLDRIVTDEFNLPIAT----YMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDL-HISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPASVVNSTC-NNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKM--------PENNSWGN*NSDNIYI 3915
C +Y +C K NP ++C P + + L K+CP+ N CC+ QL++L+ LS + CP C NF+ L+C TC PNQ F+ V G G V Y E FYQ F +SC V + +A + A+ T+CG C+ + GD + AP I + + ++ +N+ + CN + G DD CSCQDC ASCPA PQ TF + + G + ++ I+ F ++ I + F + +D + P S DK L +F WG +VA L +L + +I + L+ G++ ++TTDPVELWS+P+S AR K + D++FGPF+RT Q+I+ +R+ + + + + +N + + ++DLL + L + +++V+S L+DIC+ PL+PD C + S++QYFQNN T L ++T L T + D + C P K T C D+G PVFP+LA GG+ K+Y+++ AL++TF +NN + + +A L WE+AFL ++ F + +++ AERS++DEI+R + DL A SYI++F Y+++ LG Y++ ++ VDSK TLGL V +VL +V ++GF+SYL + +L+IL+VVPFLVL+VG DN+FI V YQR E I R + +V PSMLL SLSE++ FF G +T MPAV+ F+L + AV+ DFLLQ++ +A+L LD+KR EA R+DV CCV+ + P G+L F K YAP L R +V VG PVYF+ GYN+ SE N IC ++GCN S ++ A++ P +Y++ +SW+DDF W S CCRLY G FCP++V + C NC + RP + F YL +FL + P+++CPKGG AAY +VN+ + ++ A+ FM YH LK DYTEAL+ + E+AA++T L+ G FEV PY++ VFYEQYLT+ + L +CL V+ +LLGLD ++ L+ I++I+ GFM LWGI NA+S++NLV A+G+SVEF++HI R++ + T +ERA+E + MGS+V +G+ +T L GI+VL +K+QL QIF+FR+ L I + G H ++FLPV LS+ GP +N +EQK+ E + P + S + +DNIY+
Sbjct: 33 CAFYDECGK-NPELSGSLMTLSNVSCLSNTPARKIT-GDHLILLQKICPRLYT-GPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAY---EAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQG-DDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGF----RVAPARDKSKMVDPK----KGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKN--FSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLL--LLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGY-KGKDYSEAEALIMTFSLNNYPAGDPRLAQAKL-WEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR---EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG--------EGLLLGFFQKAYAPFLLHWITRGVV----------------------------------------------VGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSS---CCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDG-------QVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVS-TADNIYV 1261
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Human
Match: NPC1 (NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897]) HSP 1 Score: 632.098 bits (1629), Expect = 0.000e+0 Identity = 347/696 (49.86%), Postives = 478/696 (68.68%), Query Frame = 1
Query: 1756 FLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRL-YPDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLG-NSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKK 3834
F+N V+N+ N +L IS+TAERS++DE++R+S++D+FT+ +SY IMF Y+++ LG + +++ VDSKV+LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FILVQ YQR DE + L +Q++ RV+ +V PSM LSS SE++AFF G ++ MPAV FSL+A AV DFLLQIT +++L LD KR E R+D+ CCVR T V A L F Y+P+L K +R +V+ FVG F+++ ++ + + L+Q LSMP DSYM++YF +++ YL GPPVYF++++G++Y S QNM+CG GCN SL+ Q+F A+Q N T I + +SW+DD+F W K + CCR+ FC ASVV+ C C P K RP F +L FL++NP+ +C KGGHAAY AVNI +GATYFMTYHT+L+T +D+ +ALK + IA++VTE T+G N + + V PYSVFYVFYEQYLT+ LGV LG + LVT VLLG + + +I+ I +++ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HI RA+ V +R+ERA E L MGSSV SGITLTK GGI+VLAF+KSQ+FQIFYFRMYL +V+ GA H +IFLPV LS+ GP++N+ K
Sbjct: 280 FINFVKNYK--NPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQR-DERLQGETL--DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQAS-------ESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSS--CCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHG-----TRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTE----TMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 952 HSP 2 Score: 139.043 bits (349), Expect = 1.641e-32 Identity = 95/286 (33.22%), Postives = 143/286 (50.00%), Query Frame = 1
Query: 778 FTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY-----------------DKDYGNGIV-----PATPEV-DDISTFDKCGAKVEAYLTLWFYRWGMFVARR--CLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFT----WINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIK 1548
+TILG+D I+ I + AF ++ + ++ + +Y D G + P++P + + S D A E L F RWG F R C+I S+ I A S G++ +VTT+PV+LWS+PSS AR K+YFD++FGPF+RTEQ+II R P T + Y S ++ +GP +I +L +V L I N+ + N L+DIC PLSP C ++SV+ YFQN+ + LD D+F A Y + C++
Sbjct: 4 WTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGTAWLLTSTFPSSPVLPGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITA--CSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLII----RAPLTDKHIYQPYP-SGADVPFGPPLDIQILHQVLDLQIAIENIT--ASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDF-FVYADYHTHFLYCVR 279
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Celegans
Match: ncr-1 (NPC intracellular cholesterol transporter 1 homolog 1 [Source:UniProtKB/Swiss-Prot;Acc:Q19127]) HSP 1 Score: 449.129 bits (1154), Expect = 7.564e-135 Identity = 357/1324 (26.96%), Postives = 612/1324 (46.22%), Query Frame = 1
Query: 94 HCKNDKCIWYGQCDKSNPNK----ILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDT--------GYGGSIQ-------AVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALG--DATSNAPFQINYL--NEVK---GMNQTMLPCNMNGGEDDGE----ACSCQDCR----ASCXXXXXXXXXSKTFTILGIDGW-VFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGN-GIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDE------------FNLPIAT--YMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQY----NNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTY--QRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFY-APMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIW-SKQSGNPPCCRLY--PDGSFCP-----ASVVNSTCNNC----------PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILK--TPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILG-------FHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCG 3813
H + CI G C K N + N P ++ + + CP D LCC Q L Q++ A I G CP+C NF +L+C TC PNQ +FV++ G+ Q V Y L+ +F +G+F+SC +V A+ +C +T C + + +G + N P +L + +K T + N G + ACS +C A+ + +T + GI +F++ G+ +++ ++F YD+DY N + E + + GA + ++ GM R +G + + G+I K +T+ V++WSSP S AR+ + F+ NFG R +QI+++ + D + YGPVF+ D+ + ++N I N+ T L+D+C++P+ P Y+ C +MS YFQ N LD E F+ T +M+ + CI P + K TK C G +GGP P + FG + N+ + ++++T +V + +I+ A WEK FL + + E + + S+ AERS+ DEI+ ++ ++ T+ ++ + YVT +LG+Y N + I V S++ LG+ +V+I L+S CS G +S + L V F+V +GV F++V+ Y QR Y S + E + V++ P+M SSL + +FF G T++PA++ F LYA AVL D +L T+ +A+ + D +R + + ++ +++ A + + + + F F AP L R + I F+ + + I V +Q ++ + SY+ +F L + VGPPV+F V ++ + QN C GC++ S + A + TY+S +W+D++ W S++S PCC++Y +FC +++ + C C P + HRP +VF +L FL + P+ +C GG A++ A++ ++ I A+ FMT+H L SD+ +A+ + A V+ +L+ ++ ++ V YS + FYEQY T+ L QL + + V + V LG+D K FHI+ FMY++ IP+NALS NLVM+ GI +EF ++++ Y +RA + +G +LSG +T G + L+ + Q+ +++F+++L ++ A HA+I LP+ L+F G
Sbjct: 16 HHGDAGCIMRGLCQKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNK--LCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTF--GGQPALRVMCTST--PCTLTNWLEFIGTQNLDLNIPIHTKFLLYDPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAFIGSLAVLLCVGFVF-----TSYDEDYTNLRQTQSGEESPKRNRIKRTGAWIHNFMENNARDIGMMAGRNPKSHFFIGCAVLIFCLPGMIYHKESTNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLS---------HRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSDGRTIT-LDDVCYRPMGPGYD-CLIMSPTNYFQGNKEHLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQK-TKSGLSCMGTYGGPSAPNMVFGK--NSTNHQAANSIMMTILVTQ---RTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERSITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIINLLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQCPE-IVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFLALFVWDTQRELNGKPEFFFPYQIKDLL---GAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTRIITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKS---PCCKVYVHDPNTFCSTNRNKSALDDKACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFTSRG-------RIQASQFMTFHKKLSISNSSDFIKAM----DTARMVSRRLERSIDDTAH--VFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGIDVKGAACAVICQVSNYFHIV-------AFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYACSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSSAVHALIILPILLAFGG 1284
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Celegans
Match: ncr-1 (NPC intracellular cholesterol transporter 1 homolog 1 [Source:UniProtKB/Swiss-Prot;Acc:Q19127]) HSP 1 Score: 449.129 bits (1154), Expect = 7.564e-135 Identity = 357/1324 (26.96%), Postives = 612/1324 (46.22%), Query Frame = 1
Query: 94 HCKNDKCIWYGQCDKSNPNK----ILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDT--------GYGGSIQ-------AVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALG--DATSNAPFQINYL--NEVK---GMNQTMLPCNMNGGEDDGE----ACSCQDCR----ASCXXXXXXXXXSKTFTILGIDGW-VFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGN-GIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDE------------FNLPIAT--YMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQY----NNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTY--QRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFY-APMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIW-SKQSGNPPCCRLY--PDGSFCP-----ASVVNSTCNNC----------PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILK--TPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILG-------FHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCG 3813
H + CI G C K N + N P ++ + + CP D LCC Q L Q++ A I G CP+C NF +L+C TC PNQ +FV++ G+ Q V Y L+ +F +G+F+SC +V A+ +C +T C + + +G + N P +L + +K T + N G + ACS +C A+ + +T + GI +F++ G+ +++ ++F YD+DY N + E + + GA + ++ GM R +G + + G+I K +T+ V++WSSP S AR+ + F+ NFG R +QI+++ + D + YGPVF+ D+ + ++N I N+ T L+D+C++P+ P Y+ C +MS YFQ N LD E F+ T +M+ + CI P + K TK C G +GGP P + FG + N+ + ++++T +V + +I+ A WEK FL + + E + + S+ AERS+ DEI+ ++ ++ T+ ++ + YVT +LG+Y N + I V S++ LG+ +V+I L+S CS G +S + L V F+V +GV F++V+ Y QR Y S + E + V++ P+M SSL + +FF G T++PA++ F LYA AVL D +L T+ +A+ + D +R + + ++ +++ A + + + + F F AP L R + I F+ + + I V +Q ++ + SY+ +F L + VGPPV+F V ++ + QN C GC++ S + A + TY+S +W+D++ W S++S PCC++Y +FC +++ + C C P + HRP +VF +L FL + P+ +C GG A++ A++ ++ I A+ FMT+H L SD+ +A+ + A V+ +L+ ++ ++ V YS + FYEQY T+ L QL + + V + V LG+D K FHI+ FMY++ IP+NALS NLVM+ GI +EF ++++ Y +RA + +G +LSG +T G + L+ + Q+ +++F+++L ++ A HA+I LP+ L+F G
Sbjct: 16 HHGDAGCIMRGLCQKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNK--LCCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKEGFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTF--GGQPALRVMCTST--PCTLTNWLEFIGTQNLDLNIPIHTKFLLYDPIKTPPSDRSTYMNVNFTGCDKSARVGWPACSTSECNKEEYANLIDLDDGKTSGQTCNVHGIACLNIFVMLAFIGSLAVLLCVGFVF-----TSYDEDYTNLRQTQSGEESPKRNRIKRTGAWIHNFMENNARDIGMMAGRNPKSHFFIGCAVLIFCLPGMIYHKESTNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLS---------HRDFQSSGKLYGPVFHKDIFEELFDILNAIKNISTQDSDGRTIT-LDDVCYRPMGPGYD-CLIMSPTNYFQGNKEHLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQK-TKSGLSCMGTYGGPSAPNMVFGK--NSTNHQAANSIMMTILVTQ---RTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERSITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIINLLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQCPE-IVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFLALFVWDTQRELNGKPEFFFPYQIKDLL---GAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTRIITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKS---PCCKVYVHDPNTFCSTNRNKSALDDKACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFTSRG-------RIQASQFMTFHKKLSISNSSDFIKAM----DTARMVSRRLERSIDDTAH--VFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGIDVKGAACAVICQVSNYFHIV-------AFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYACSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSSAVHALIILPILLAFGG 1284
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Celegans
Match: ncr-2 (NPC intracellular cholesterol transporter 1 homolog 2 [Source:UniProtKB/Swiss-Prot;Acc:P34389]) HSP 1 Score: 355.14 bits (910), Expect = 4.412e-102 Identity = 312/1250 (24.96%), Postives = 563/1250 (45.04%), Query Frame = 1
Query: 196 NATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV--DTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGD---ATS---NAPFQINYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTIL---GIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQL---------DRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEI-CNGDFGGPVFPYLAFGGFGDK----KNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLG----QYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQ---KIARVVSKVGPXXXXXXXXXXXAFFCG------VMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKF---YAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQL--FMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG-SFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCG 3813
N T K C + + +CC QL + ++S A+ I G CP+C NF +L+C TC P+Q F+ V TG + + + +N +F +GL+ SC + ++ + + ++ G K FY +G A S N FQ + + MN PC+ + G AC DC + K T + + +++ I G + V+ ++I Y + + P +D D +E R+ V + LI +S+G+I+A G T V+ S+ RRN+ F +FGP +R EQI +IN + +++ FN+ L + L+ +I N+ N+ KL+DIC+KP+ ++ CA+MS YFQN T D I D+ + + + CI++P + + + E+ C G+F GP+ P L FGG + + Y + ++IT ++ DQ A+ WE AFLN++ + + + ++ E SV +EI ETD ++ + +V LG ++I V K+ + + AV+I +ISV CS+G +S V T + V+ F++ +G++ +F++++T+Q Y N++ + +I+ V+ + P +L +SL S F V MPAV++F+ +A A+L D + V++ + DA+R + + ++ ++N + + G L D F AP+L K R + FF + A + NQ ++ + SY+ +F + L++GPP++F+V+ + QN C +GC++ S+ ++ ++N Y+ WLD + + G+ CC++ DG FC S + ++ + + + + + L FL PS+QC GG A A+N+ +I + YF T+ L SD + L ++ A + + ++ L +V YS F+ +YEQYLT+ ++ + + L V + + L ++ +L+ F ++ + +MYL GI +N +S++N+ M++GI+VEF ++ + + R ERA LV GS+ LSGI + L+F+ S++ ++ +GI + A H ++++P L+ G
Sbjct: 62 NPTYMARFEKYCSYLVQEEDKAQVCCTELQLKGMTDRISNAATILGSCPSCFDNFAKLWCQFTCSPDQSKFMKVMETTGPKNVVVKMEFKVNRDFVEGLYESCRHTWFANGLALRLMSLGG----KVSFENFYGFMGTKNLAQSIPINTEFQFSRMK--NAMNIPTTPCHKSAGPKV-PACGAIDCPTNAHQLVDISKVEHLGTKVFHPHFPDFEWLLKIC-GCLALTVLLVFILKYSCHRR-----------SAPNGEDGCYVDLGKGNLEVQFEGLCARYANAVIKHPLIFVSLGLIVAAACCSGNFKFHSLTHSVDQVSAADGETRRNEKKFIHSFGPNHRIEQI-----------FINLPPTTKSM-----FNMPLFEEMFQLVGNIQNLTACYG--NSSVKLDDICYKPIGKNH-GCAIMSPTNYFQNKWTNFENAGPPTIDDEIFDDQ-------HWEHLKYCIRNPLTV--STYSEMSCFGEFSGPIDPILVFGGSNESIKGAEMYYTARTIMITVLIRGPEDQ-------AIAWETAFLNMMSRYEMKHANF--TFMTETSVAEEIHTAVETDKIVSVIACAAVLIWVITMLGINHWPESSILSALVHHKLLISISAVMISVISVWCSIGMFSLFGVHATDNAIVVLFFVITCLGINRIFVIIRTFQANGHCYGLPNISYREMNHRISNVMRRSIPIVLTNSLICSTCLFLAGGVLPYVSVSMPAVEVFARHAGLAILMDTAFYLLVMLPLFQYDARREMSGKCEIWPWYELSNE----SKINLCMEAVDGNLRSPVDWFKLAIAPLLLKKICRIWIATFFFVSLIIACYCTLCLEFGFNQVMAFSETSYLTKHFQNMNENLNIGPPLWFVVEGDVKWHDPKMQNKFCTLAGCDDNSMGNKIRSLAYAENYKGNYLHGDVNIWLDSYLQFMHPRGS--CCKM--DGKQFCDPSNATHCSSCSSSSVASLTTTEYEFYRN-LHHFLETPPSIQCAHGGMALAKPAINLTRNG-------KIQSAYFSTFFKKLNL-SDSIQ-LYDAWRFAKYLADDIEREL-EIPGVKVYVYSTFFPYYEQYLTLSTTVYTLVVLVLFVAFVTISLFLRVNLAGSLVTVFVLLSSYLHLMEWMYLLGITVNVVSVINMAMSLGIAVEFFGQMLHGFYNSKKPKREERAFAALVSNGSTTLSGIFPAIMITAGCLSFADSRVLITYFCNQLVGIGLVCAVHGVVYMPTLLAIFG 1236
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Celegans
Match: ptr-2 (PaTched Related family [Source:UniProtKB/TrEMBL;Acc:P91129]) HSP 1 Score: 104.375 bits (259), Expect = 2.751e-22 Identity = 116/475 (24.42%), Postives = 217/475 (45.68%), Query Frame = 1
Query: 1453 FQNNITQLDRIVTDEFN-LPIATYMDQIMECIKD-----PTNIKPTKFKEICNGDFGGPVFPYLAFGGFG-------------DKKNYTDSTALVITFIVNNALDQNSKQIK-AALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDL--FTIALSYIIMFTYVTITLGQYNNIK-KIPVD---SKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMR-----VDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEI--------FDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYL-SVGPPVYFIVKDGYNYKSENSQNMI 2757
F N + QLD+ + L Y C++ P+N ++ N F +PY FG G +N TD A + + L + +++ + +WE ++ + E + + I+Y +++ DE+ R ++T + F I+++ +I+F+ TL + I +D SK L + V+ I++ VGF S + +P I+ V+PFLVLAVGVDN+F++V +R +S+ T +++ ++ S+L++S ++ L+F G +T +PAV+IF +Y A+ F F+ QIT A L L K + R ++ + + ++ T + V H++ F ++YAP+L VR + +++FV + L A I L + +DSY I ++ L Y G V ++ + + ++ S++ +
Sbjct: 110 FANAVYQLDKYIQTRVRVLHNGHYYSYKNLCLQYKNGGCPSNKHVHILSDLHNHGFN-ITYPYFRFGSEGGYIGSSLGGVTVMKGENETDILASAKAWFMIYHLKFHPEEMSYISGEWELELGRMLTQYPE-DPYISITYFHSQTLADELKRNADTLIPRFIISITLLIVFS----TLCSLSFIDGSFSIDWVLSKPILSILGVVSAGIAILTGVGFLSLMGMPYNDIV-GVMPFLVLAVGVDNMFLMVAAVRR-----TSRTHTVHERMGECLADAAVSILITSSTDVLSFGVGAITTIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEASGRNSLFLIEAVSAEKKTSLSTFQRLFNLGSVPDHSASHDVKQPLTSRFFGEWYAPVLMHPVVRGIAMVWFVIYLLGASYGCSRIKEGLEPVNLLVEDSYAIPHYRLLEKYFWKYGQQVQIVINNAPDLRNHTSRDRV 572 HSP 2 Score: 62.3882 bits (150), Expect = 2.226e-9 Identity = 41/110 (37.27%), Postives = 66/110 (60.00%), Query Frame = 1
Query: 3475 GFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLS 3804
G+M LWG+ ++A+SM+ ++M+IG SV++ AHI YVV R DT R +E L +G + G ++ + + VLA + + F+ + L I + G H ++FLPV LS
Sbjct: 747 GYMTLWGVNLDAISMITIIMSIGFSVDYSAHIAYGYVVSREDTAAGRVKEALSALGWPLSQG-AMSTIIAVSVLADIPAYMIVTFFKTVVLSISL-GLLHGLVFLPVLLS 854
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Celegans
Match: ptc-3 (pep chromosome:WBcel235:II:2845384:2852128:-1 gene:WBGene00004210.1 transcript:Y110A2AL.8c.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ptc-3) HSP 1 Score: 98.9821 bits (245), Expect = 1.887e-20 Identity = 113/486 (23.25%), Postives = 198/486 (40.74%), Query Frame = 1
Query: 1438 SVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPY---LAFGGFG-DKKNYTDSTALVITFIVNNALD-----QNSK-QIKAALD---------------WEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVP------VAKVKYSGI--------LHE-------IFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMI 2757
S++++ Q N +L +T E Y D + C G FG + + L GG D + AL F+V+ A D +N K LD W++ F + + A S+ D ++ S+ + I + YI+M Y T G++ + V S V L +C V++V IS C +GF ++L + +VVPFL L +G+D++F+L+ YDE N+ + +I ++ + G S++L+S++ LAF G + +PA++ F A + F+ + + + A++ +D +R + D+ C R N + +VP ++ + +G HE +K Y P L V+ V+I +F L ++ + L +P+ + + A Y S P F V G N Q +I
Sbjct: 477 SLLKWMQENPERLGEFLTKEEMPDYPNYGDVMTGG---------------CKG-FGKKIMEWPEDLIIGGIQRDNGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHFQPWMAGEIISTWQRNFTKRLYSHELNRERRQFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQGWW-LAVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHN---YDEII---NICNKNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRGNPQMATSQSVPSNVSNMSSRAELAGYEKQADEYKRHEPWYTVGGFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYFSFYP--MFAVLRGDKLDIPNQQQLI 937 HSP 2 Score: 75.485 bits (184), Expect = 2.398e-13 Identity = 63/197 (31.98%), Postives = 96/197 (48.73%), Query Frame = 1
Query: 3226 EIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGP 3816
EI A+ E + L N P + + F+EQYLT+ L+ + + V V +L+ W ATLI+ +I + + GFM L GI +N +S V L+ A+GI VEF AH+ A++ T +R L M V G T L G+++L FS+ ++F +V G + + LPV L+ GP
Sbjct: 1109 EIRATCEEYSERGLSNH------PSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTI-ELGGFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTALG-TIDQRLESCLQHMFVPVYHGAISTFL-GVVMLVFSEFDFVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGP 1296
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0303907) HSP 1 Score: 868.611 bits (2243), Expect = 0.000e+0 Identity = 498/1285 (38.75%), Postives = 761/1285 (59.22%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS-----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGT-THEKCDPVAFYKALGDATSN-APFQINYL--------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI---FIYLKKNKYDKDY---GNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD-----YEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGF---GDK----KNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD--LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL-------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI 3837
C+WYG C+ ++ + NC Y G K + G + L K C + N CC+ +Q+ L+ + A I CP+CM N +R C TC P Q F+ V I +V +++ + + SC V + A D +CG + +C+P ++ +GDAT+ PFQI Y+ N +N T +PCN ACSC DC SCP PP + F I+G+D + ++ A F++ + +++ F++ + + D ++ GN + P ++ S F+K GA E +L +F +WG + A + L G + ++L GI ++TTDPV+LW+SP+S +R +++FD F PFYR EQIII + I ++ S T+GPVF+ + L +V L I + N T+L+DIC+ PLS D +C V S+ YF ++ +LD DE N TY+D + +CI +P +C +GGPV P +A GGF GD+ + + A+++TF+V N N ++ AL WEK F+ + N+++ N + I++T+ERS++DE++R+S++D+ TI +SY+IMF Y+ I+LG K++ +DSK+TLG+ V+IVL SV SVG + Y+ +P TLII+EV+PFLVLAVGVDN+FILVQT+QR N T EQ++ R++ KVGPSMLL+SLSES FF G +++MPAV+ F+LYA A++ DFLLQIT +++ LD KR E R+D+ C ++ P + G+L++ F Y P L K VR V++ F W F+++ I + L+Q+L+MP+DS++++YF +L L++GPPVYF++K Y + + QN++C CN+ S+L Q+++AS++ N TYI+ +SW+DD+F W+ + + CC+ D G FCP +++C C + RP+ K F YL FFL +NP C K GHAAYG AV N SH+ + I A+YFM YHTILK+ +DY AL+++ +I+A++T+ L+ L ++ EV PYSVFYVFYEQYLT++ +G+ + + +VTFVL+G D + L++ I +I+ ++ G MY W I +NA+S+VNLVMA+GISVEF +H+V ++ +S ++I+RA + L +MGSS+ SGITLTK GI+VLAF+KSQ+FQ+FYFRMYLGIV+ GAAH +IFLPV LS+ G ++ ++
Sbjct: 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMA-TDGLELLKKRCGFLLENSEN-KFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCN-QAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYF----VIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVN---LPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA------NGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD--HDEDNGFNVTYLDALYDCISNPY---------LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKN--HHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQR---KPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKK--------PDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASS--CCKYRKDSGDFCPHQ--DTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSN----SHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARL 1269
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0303906) HSP 1 Score: 868.611 bits (2243), Expect = 0.000e+0 Identity = 498/1285 (38.75%), Postives = 761/1285 (59.22%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS-----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGT-THEKCDPVAFYKALGDATSN-APFQINYL--------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI---FIYLKKNKYDKDY---GNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD-----YEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGF---GDK----KNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD--LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL-------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI 3837
C+WYG C+ ++ + NC Y G K + G + L K C + N CC+ +Q+ L+ + A I CP+CM N +R C TC P Q F+ V I +V +++ + + SC V + A D +CG + +C+P ++ +GDAT+ PFQI Y+ N +N T +PCN ACSC DC SCP PP + F I+G+D + ++ A F++ + +++ F++ + + D ++ GN + P ++ S F+K GA E +L +F +WG + A + L G + ++L GI ++TTDPV+LW+SP+S +R +++FD F PFYR EQIII + I ++ S T+GPVF+ + L +V L I + N T+L+DIC+ PLS D +C V S+ YF ++ +LD DE N TY+D + +CI +P +C +GGPV P +A GGF GD+ + + A+++TF+V N N ++ AL WEK F+ + N+++ N + I++T+ERS++DE++R+S++D+ TI +SY+IMF Y+ I+LG K++ +DSK+TLG+ V+IVL SV SVG + Y+ +P TLII+EV+PFLVLAVGVDN+FILVQT+QR N T EQ++ R++ KVGPSMLL+SLSES FF G +++MPAV+ F+LYA A++ DFLLQIT +++ LD KR E R+D+ C ++ P + G+L++ F Y P L K VR V++ F W F+++ I + L+Q+L+MP+DS++++YF +L L++GPPVYF++K Y + + QN++C CN+ S+L Q+++AS++ N TYI+ +SW+DD+F W+ + + CC+ D G FCP +++C C + RP+ K F YL FFL +NP C K GHAAYG AV N SH+ + I A+YFM YHTILK+ +DY AL+++ +I+A++T+ L+ L ++ EV PYSVFYVFYEQYLT++ +G+ + + +VTFVL+G D + L++ I +I+ ++ G MY W I +NA+S+VNLVMA+GISVEF +H+V ++ +S ++I+RA + L +MGSS+ SGITLTK GI+VLAF+KSQ+FQ+FYFRMYLGIV+ GAAH +IFLPV LS+ G ++ ++
Sbjct: 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMA-TDGLELLKKRCGFLLENSEN-KFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCN-QAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYF----VIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVN---LPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA------NGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD--HDEDNGFNVTYLDALYDCISNPY---------LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKN--HHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQR---KPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKK--------PDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASS--CCKYRKDSGDFCPHQ--DTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSN----SHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARL 1269
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0079957) HSP 1 Score: 868.611 bits (2243), Expect = 0.000e+0 Identity = 498/1285 (38.75%), Postives = 761/1285 (59.22%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS-----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGT-THEKCDPVAFYKALGDATSN-APFQINYL--------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI---FIYLKKNKYDKDY---GNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD-----YEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGF---GDK----KNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD--LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL-------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI 3837
C+WYG C+ ++ + NC Y G K + G + L K C + N CC+ +Q+ L+ + A I CP+CM N +R C TC P Q F+ V I +V +++ + + SC V + A D +CG + +C+P ++ +GDAT+ PFQI Y+ N +N T +PCN ACSC DC SCP PP + F I+G+D + ++ A F++ + +++ F++ + + D ++ GN + P ++ S F+K GA E +L +F +WG + A + L G + ++L GI ++TTDPV+LW+SP+S +R +++FD F PFYR EQIII + I ++ S T+GPVF+ + L +V L I + N T+L+DIC+ PLS D +C V S+ YF ++ +LD DE N TY+D + +CI +P +C +GGPV P +A GGF GD+ + + A+++TF+V N N ++ AL WEK F+ + N+++ N + I++T+ERS++DE++R+S++D+ TI +SY+IMF Y+ I+LG K++ +DSK+TLG+ V+IVL SV SVG + Y+ +P TLII+EV+PFLVLAVGVDN+FILVQT+QR N T EQ++ R++ KVGPSMLL+SLSES FF G +++MPAV+ F+LYA A++ DFLLQIT +++ LD KR E R+D+ C ++ P + G+L++ F Y P L K VR V++ F W F+++ I + L+Q+L+MP+DS++++YF +L L++GPPVYF++K Y + + QN++C CN+ S+L Q+++AS++ N TYI+ +SW+DD+F W+ + + CC+ D G FCP +++C C + RP+ K F YL FFL +NP C K GHAAYG AV N SH+ + I A+YFM YHTILK+ +DY AL+++ +I+A++T+ L+ L ++ EV PYSVFYVFYEQYLT++ +G+ + + +VTFVL+G D + L++ I +I+ ++ G MY W I +NA+S+VNLVMA+GISVEF +H+V ++ +S ++I+RA + L +MGSS+ SGITLTK GI+VLAF+KSQ+FQ+FYFRMYLGIV+ GAAH +IFLPV LS+ G ++ ++
Sbjct: 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMA-TDGLELLKKRCGFLLENSEN-KFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCN-QAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYF----VIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVN---LPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA------NGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD--HDEDNGFNVTYLDALYDCISNPY---------LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKN--HHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQR---KPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKK--------PDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASS--CCKYRKDSGDFCPHQ--DTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSN----SHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARL 1269
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0303905) HSP 1 Score: 868.611 bits (2243), Expect = 0.000e+0 Identity = 498/1285 (38.75%), Postives = 761/1285 (59.22%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS-----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGT-THEKCDPVAFYKALGDATSN-APFQINYL--------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI---FIYLKKNKYDKDY---GNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD-----YEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGF---GDK----KNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD--LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL-------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI 3837
C+WYG C+ ++ + NC Y G K + G + L K C + N CC+ +Q+ L+ + A I CP+CM N +R C TC P Q F+ V I +V +++ + + SC V + A D +CG + +C+P ++ +GDAT+ PFQI Y+ N +N T +PCN ACSC DC SCP PP + F I+G+D + ++ A F++ + +++ F++ + + D ++ GN + P ++ S F+K GA E +L +F +WG + A + L G + ++L GI ++TTDPV+LW+SP+S +R +++FD F PFYR EQIII + I ++ S T+GPVF+ + L +V L I + N T+L+DIC+ PLS D +C V S+ YF ++ +LD DE N TY+D + +CI +P +C +GGPV P +A GGF GD+ + + A+++TF+V N N ++ AL WEK F+ + N+++ N + I++T+ERS++DE++R+S++D+ TI +SY+IMF Y+ I+LG K++ +DSK+TLG+ V+IVL SV SVG + Y+ +P TLII+EV+PFLVLAVGVDN+FILVQT+QR N T EQ++ R++ KVGPSMLL+SLSES FF G +++MPAV+ F+LYA A++ DFLLQIT +++ LD KR E R+D+ C ++ P + G+L++ F Y P L K VR V++ F W F+++ I + L+Q+L+MP+DS++++YF +L L++GPPVYF++K Y + + QN++C CN+ S+L Q+++AS++ N TYI+ +SW+DD+F W+ + + CC+ D G FCP +++C C + RP+ K F YL FFL +NP C K GHAAYG AV N SH+ + I A+YFM YHTILK+ +DY AL+++ +I+A++T+ L+ L ++ EV PYSVFYVFYEQYLT++ +G+ + + +VTFVL+G D + L++ I +I+ ++ G MY W I +NA+S+VNLVMA+GISVEF +H+V ++ +S ++I+RA + L +MGSS+ SGITLTK GI+VLAF+KSQ+FQ+FYFRMYLGIV+ GAAH +IFLPV LS+ G ++ ++
Sbjct: 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMA-TDGLELLKKRCGFLLENSEN-KFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCN-QAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYF----VIMAAVFLVGVLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVN---LPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA------NGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD--HDEDNGFNVTYLDALYDCISNPY---------LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKN--HHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQR---KPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKK--------PDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASS--CCKYRKDSGDFCPHQ--DTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSN----SHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARL 1269
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0343610) HSP 1 Score: 867.84 bits (2241), Expect = 0.000e+0 Identity = 498/1282 (38.85%), Postives = 759/1282 (59.20%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS-----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGT-THEKCDPVAFYKALGDATSN-APFQINYL--------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI---FIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD-----YEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGF---GDK----KNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD--LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL-------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI 3837
C+WYG C+ ++ + NC Y G K + G + L K C + N CC+ +Q+ L+ + A I CP+CM N +R C TC P Q F+ V I +V +++ + + SC V + A D +CG + +C+P ++ +GDAT+ PFQI Y+ N +N T +PCN ACSC DC SCP PP + F I+G+D + ++ A F++ + +++ F++ + + + D GN + P ++ S F+K GA E +L +F +WG + A + L G + ++L GI ++TTDPV+LW+SP+S +R +++FD F PFYR EQIII I ++ S T+GPVF+ + L +V L I + N T+L+DIC+ PLS D +C V S+ YF ++ +LD DE N TY+D + +CI +P +C +GGPV P +A GGF GD+ + + A+++TF+V N N ++ AL WEK F+ + N+++ N + I++T+ERS++DE++R+S++D+ TI +SY+IMF Y+ I+LG K++ +DSK+TLG+ V+IVL SV SVG + Y+ +P TLII+EV+PFLVLAVGVDN+FILVQT+QR N T EQ++ R++ KVGPSMLL+SLSES FF G +++MPAV+ F+LYA A++ DFLLQIT +++ LD KR E R+D+ C ++ P + G+L++ F Y P L K VR V++ F W F+++ I + L+Q+L+MP+DS++++YF +L L++GPPVYF++K Y + + QN++C CN+ S+L Q+++AS++ N TYI+ +SW+DD+F W+ + + CC+ D G FCP +++C C + RP+ K F YL FFL +NP C K GHAAYG AV N SH+ + I A+YFM YHTILK+ +DY AL+++ +I+A++T+ L+ L ++ EV PYSVFYVFYEQYLT++ +G+ + + +VTFVL+G D + L++ I +I+ ++ G MY W I +NA+S+VNLVMA+GISVEF +H+V ++ +S ++I+RA + L +MGSS+ SGITLTK GI+VLAF+KSQ+FQ+FYFRMYLGIV+ GAAH +IFLPV LS+ G ++ ++
Sbjct: 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMA-TDGLELLKKRCGFLLENSEN-KFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCN-QAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYF----VIMAAVFLVGVLVFLMGSFLFTQDDNFQVD-GNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIII---KAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA------NGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD--HDEDNGFNVTYLDALYDCISNPY---------LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKN--HHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQR---KPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKK--------PDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASS--CCKYRKDSGDFCPHQ--DTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSN----SHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARL 1265
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Zebrafish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161]) HSP 1 Score: 972.615 bits (2513), Expect = 0.000e+0 Identity = 554/1272 (43.55%), Postives = 788/1272 (61.95%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN--PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVD----TGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQINYLNE---VKGM----NQTMLPCNMNGGEDDG-EACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYL-KKNKYDKDYGNGIVPATPEV----DDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVP--KDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPT-KFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIV 3840
CIWYG+C S P K LNCNYTGP PL N G + L +LCP+ D +CC+T QL TL + CP C NF+ L+C LTC P Q F++V S+ VTY + + F +FN+C +V S+N A+ +CG C P + + + + PF I + V+GM N+T N + DDG E CSCQDC C P P + ILG+D FI+ + AF +I + + + +++ +YG + P D+ S + G + E L L F RWG R+ L ++ +++ + S G+ ++TT+PVELWS+PSS AR+ K+YFD++FGPF+RTEQ+II + F+ I DI + + P+ N+ LL +V L I N+ K N L+DIC PLSP + C ++SV+ YFQN+ LD DEF L Y ++ C PT++ T + + C G FGGPVFP+L GG+ D Y ++TALVITF V N L+ +++++ AL WEK F+ ++N+ N +L +S+++ERS++DEIDR+S +D+ TI +SYIIMF Y+++ LG+ N+ + + VDSK++LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FI+VQTYQR DE + L Q+I R++ V PSM LSS SE++AFF G ++ MPAV+ FSL+A A+ DFLLQI+ +++L LD KR EA R+D+LCCV++++ + K G L F K YAP + K VR LVV FVG F+++ ++ + + L Q LSMP DSY++NYF L+ YL GPPVYF+V+DG++YK+ QN +CG GCN SL+ Q++ AS N T IS +SWLDD+F W K CCR Y G+FC ASVV+ +C +C P + K RP+ F +L FL++NP+++C KGGHAAYG AV++K+ + ++GATYFM+YHTILK SD+ A+K + E+ ++T+ L T + ++V PYSVFYVFYEQYLT+ + LGV L + +VT VLLG + + +++ F I +I+ +MFG M+LW I +NA+S+VNLVM+ GISVEF +HIVRA+ + +R+ERA E L MGSSV SGITLTK GGI++LA SKSQ+FQIFYFRMYL IV+ GAAH +IFLPV LS+ GP++N+ K++
Sbjct: 24 HGQHCIWYGECGNSPNVPEKKLNCNYTGPAVPLPNE-GQELLQELCPRLVYADNR--VCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTPQIWIQYMFSISNGQVPFGIEPIFTDVPVQGMTPMNNRTF---NCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHSLNSDDEASCCETVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGGFSTITGDI----IPFSPILNLSLLHQVLDLQLEIENLIAEYKGEN--VTLKDICVSPLSPYNDNCTILSVLNYFQNSHEVLDHEFQDEFFL-YNDYHTHLLYCASSPTSLDDTSRLHDPCMGTFGGPVFPWLVLGGYEDSA-YNNATALVITFPVTNYLN-DTEKLGKALAWEKEFIRFMKNYE--NPNLTVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQR-DERMPEEEL--HQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDG---------QEEKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLHTGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTASLMSNYTRISNVPSSWLDDYFDWVKPQST--CCRYYNSTGAFCNASVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNN------TDVGATYFMSYHTILKNSSDFINAMKMARELTDNITQTLST---HDKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAGPSVNKAKVL 1255
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Zebrafish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161]) HSP 1 Score: 972.23 bits (2512), Expect = 0.000e+0 Identity = 554/1277 (43.38%), Postives = 789/1277 (61.79%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN--PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVD----TGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQINYLNE---VKGM----NQTMLPCNMNGGEDDG-EACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYL-KKNKYDKDYGNGIVPATPE---------VDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVP--KDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPT-KFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIV 3840
CIWYG+C S P K LNCNYTGP PL N G + L +LCP+ D +CC+T QL TL + CP C NF+ L+C LTC P Q F++V S+ VTY + + F +FN+C +V S+N A+ +CG C P + + + + PF I + V+GM N+T N + DDG E CSCQDC C P P + ILG+D FI+ + AF +I + + + +++ +YG + P +D+ S + G + E L L F RWG R+ L ++ +++ + S G+ ++TT+PVELWS+PSS AR+ K+YFD++FGPF+RTEQ+II + F+ I DI + + P+ N+ LL +V L I N+ K N L+DIC PLSP + C ++SV+ YFQN+ LD DEF L Y ++ C PT++ T + + C G FGGPVFP+L GG+ D Y ++TALVITF V N L+ +++++ AL WEK F+ ++N+ N +L +S+++ERS++DEIDR+S +D+ TI +SYIIMF Y+++ LG+ N+ + + VDSK++LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FI+VQTYQR DE + L Q+I R++ V PSM LSS SE++AFF G ++ MPAV+ FSL+A A+ DFLLQI+ +++L LD KR EA R+D+LCCV++++ + K G L F K YAP + K VR LVV FVG F+++ ++ + + L Q LSMP DSY++NYF L+ YL GPPVYF+V+DG++YK+ QN +CG GCN SL+ Q++ AS N T IS +SWLDD+F W K CCR Y G+FC ASVV+ +C +C P + K RP+ F +L FL++NP+++C KGGHAAYG AV++K+ + ++GATYFM+YHTILK SD+ A+K + E+ ++T+ L T + ++V PYSVFYVFYEQYLT+ + LGV L + +VT VLLG + + +++ F I +I+ +MFG M+LW I +NA+S+VNLVM+ GISVEF +HIVRA+ + +R+ERA E L MGSSV SGITLTK GGI++LA SKSQ+FQIFYFRMYL IV+ GAAH +IFLPV LS+ GP++N+ K++
Sbjct: 24 HGQHCIWYGECGNSPNVPEKKLNCNYTGPAVPLPNE-GQELLQELCPRLVYADNR--VCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTPQIWIQYMFSISNGQVPFGIEPIFTDVPVQGMTPMNNRTF---NCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHSLNSDGTDLIDEASCCETVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGGFSTITGDI----IPFSPILNLSLLHQVLDLQLEIENLIAEYKGEN--VTLKDICVSPLSPYNDNCTILSVLNYFQNSHEVLDHEFQDEFFL-YNDYHTHLLYCASSPTSLDDTSRLHDPCMGTFGGPVFPWLVLGGYEDSA-YNNATALVITFPVTNYLN-DTEKLGKALAWEKEFIRFMKNYE--NPNLTVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQR-DERMPEEEL--HQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDG---------QEEKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLHTGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTASLMSNYTRISNVPSSWLDDYFDWVKPQST--CCRYYNSTGAFCNASVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNN------TDVGATYFMSYHTILKNSSDFINAMKMARELTDNITQTLST---HDKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAGPSVNKAKVL 1260
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Zebrafish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161]) HSP 1 Score: 964.911 bits (2493), Expect = 0.000e+0 Identity = 552/1274 (43.33%), Postives = 785/1274 (61.62%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN--PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVD----TGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQINYLNE---VKGM----NQTMLPCNMNGGEDDG-EACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYL-KKNKYDKDYGNGIVPATPE---------VDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVP--KDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPT-KFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRK 3831
CIWYG+C S P K LNCNYTGP PL N G + L +LCP+ D +CC+T QL TL + CP C NF+ L+C LTC P Q F++V S+ VTY + + F +FN+C +V S+N A+ +CG C P + + + + PF I + V+GM N+T N + DDG E CSCQDC C P P + ILG+D FI+ + AF +I + + + +++ +YG + P +D+ S + G + E L L F RWG R+ L ++ +++ + S G+ ++TT+PVELWS+PSS AR+ K+YFD++FGPF+RTEQ+II + F+ I DI + + P+ N+ LL +V L I N+ K N L+DIC PLSP + C ++SV+ YFQN+ LD DEF L Y ++ C PT++ T + + C G FGGPVFP+L GG+ D Y ++TALVITF V N L+ +++++ AL WEK F+ ++N+ N +L +S+++ERS++DEIDR+S +D+ TI +SYIIMF Y+++ LG+ N+ + + VDSK++LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FI+VQTYQR DE + L Q+I R++ V PSM LSS SE++AFF G ++ MPAV+ FSL+A A+ DFLLQI+ +++L LD KR EA R+D+LCCV++++ + K G L F K YAP + K VR LVV FVG F+++ ++ + + L Q LSMP DSY++NYF L+ YL GPPVYF+V+DG++YK+ QN +CG GCN SL+ Q++ AS N T IS +SWLDD+F W K CCR Y G+FC ASVV+ +C +C P + K RP+ F +L FL++NP+++C KGGHAAYG AV++K+ + ++GATYFM+YHTILK SD+ A+K + E+ ++T+ L T + ++V PYSVFYVFYEQYLT+ + LGV L + +VT VLLG + + +++ F I +I+ +MFG M+LW I +NA+S+VNLVM+ GISVEF +HIVRA+ + +R+ERA E L MGSSV SGITLTK GGI++LA SKSQ+FQIFYFRMYL IV+ GAAH +IFLPV LS+ G +L+ +
Sbjct: 24 HGQHCIWYGECGNSPNVPEKKLNCNYTGPAVPLPNE-GQELLQELCPRLVYADNR--VCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGRDASVCTPQIWIQYMFSISNGQVPFGIEPIFTDVPVQGMTPMNNRTF---NCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIILGLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHSLNSDGTDLIDEASCCETVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGGFSTITGDI----IPFSPILNLSLLHQVLDLQLEIENLIAEYKGEN--VTLKDICVSPLSPYNDNCTILSVLNYFQNSHEVLDHEFQDEFFL-YNDYHTHLLYCASSPTSLDDTSRLHDPCMGTFGGPVFPWLVLGGYEDSA-YNNATALVITFPVTNYLN-DTEKLGKALAWEKEFIRFMKNYE--NPNLTVSFSSERSIEDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQR-DERMPEEEL--HQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDG---------QEEKSEGWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLHTGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTASLMSNYTRISNVPSSWLDDYFDWVKPQST--CCRYYNSTGAFCNASVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNN------TDVGATYFMSYHTILKNSSDFINAMKMARELTDNITQTLST---HDKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSVFSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAGKSLSPR 1257
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Zebrafish
Match: NPC1L1 (NPC1-like 1 [Source:NCBI gene;Acc:100616532]) HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0 Identity = 372/1020 (36.47%), Postives = 546/1020 (53.53%), Query Frame = 1
Query: 196 NATG--FQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--------VTVDTG-YGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINY-------LNEVKGMNQTMLPCNMNGGE---DDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMI----VISIYIFIYLK-----KNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSP---DYEKCAVMSVMQYFQNNITQLDRIV--TDEFNLPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSE-TNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPAS---VVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNK 3117
N TG ++ L +CP A D CC+ QL L LS + + CP+C NF L+CA TC P+Q +T TG ++ ++ NF F+SC NV + S +AI T+CG C P +Y GD+++ AP I++ +EV + E GEACSCQDC SCP P P K F I ++G + I VF F + VI+ Y+K K K KD + D+S DK + +L F WG +AR IVL V ++I +V ++GI ++TTDPV+LWS+P S A R K + D +F PFYRT Q+I+ R + + +N + + + DL+ + L I +E +S LN+ L+D+C+ PL+P CAV S+ QYFQN+I L+ V T+ + D + C+ P + K T C D+GGPVFP+LA GG+ D + YT + AL++TF +NN + K K +WE FL +VQ + + + T+ +Y AERS++DEI+R + D+ +SY ++F Y+ + LG+Y++ K+I VDSK +GL +L+V SV S+GF++++ V +L+IL+VVPFLVLAVG DN+FI V YQR + E++I RV+ V PSMLL SLSES+ FF G ++ MPAVK F+LYAA AVL DF+LQ+T +A+L LDA+R ++ R ++ CCV ++ P + GIL + K+YAP L + R +V++ F+ ++ + + V LNQ+L+MP DSYM++YF L Y VG P YFI G+N+ SE N +C + GC++ S+ ++ A++ P +Y++ +SW+DD+ W CCRLY G FCPA+ V C P N RPD F+ +L FL+N P +QCPKGG AY +AV N+
Sbjct: 64 NVTGDHYELLKSVCPMLANGDGQTLACCSIRQLTALQNSLSLSKAVLIRCPSCAENFAYLHCATTCSPDQSQILKITKTANITQPTGIVKEAVVGYAAYISTNFSDASFDSCKNVRIPSTGGFAIATMCGRYGAALCTPQRWYDFQGDSSNGLAPLDIDFKLLQDSETSEVPAGAFAFAGQALKCNEVTPSGGEACSCQDCLQSCPVVPEPPPLPKPFMIGNLNGVLVICLTVFSCFLFLFLCYVITECTTYYMKSRKGRKGKSTKDQNANEIKFKISPKDVSCSDKASLATQEFLGSLFQSWGTLMARYPYIVLPVCLVIVLVFAVGIKDIELTTDPVQLWSAPESRAMREKAFHDAHFDPFYRTNQLILTAPGRPSHFYDSLLFGKQN--FSGIISKDLIIELLKLQQSIQAIEFWSDELNSTASLKDVCYAPLNPGNPSLTDCAVNSLPQYFQNSIDNLNAKVNMTELGVTKEVDWRDHFIYCVNSPLSFKDITALGMSCMSDYGGPVFPFLAVGGY-DNEQYTTAEALILTFSLNNYARTDVK-FKVVEEWENRFLKIVQEYQKNSTTNFTFAYMAERSLEDEINRTTAEDIPIFMISYAVIFLYIAVALGEYSSCKRILVDSKFLVGLGGILVVGCSVIASMGFYAWIGVASSLVILQVVPFLVLAVGADNIFIFVLEYQRDLRRPGEQR---EEQIGRVLGNVAPSMLLCSLSESVCFFLGALSTMPAVKSFALYAALAVLMDFVLQMTAFVALLSLDARRQDSNRCEIACCVTVD--------TPRPQKPNEGILLPLMRKYYAPFLLNSFSRVVVMVLFLVMFFSSVFLMFHVKVGLNQELAMPTDSYMLDYFAYLFKYFEVGVPTYFITTKGFNFNSEEGINAVCSSVGCDQFSMTQKIRYATEYPERSYLAIPASSWVDDYIDWLNPGSR--CCRLYTFGPNKDEFCPANETGVCLKKCMGKPEN--GVLRPDVSEFNRFLPDFLSNRPDLQCPKGGLGAYDKAVIRDNE 1064
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Zebrafish
Match: ptch1 (patched 1 [Source:ZFIN;Acc:ZDB-GENE-980526-196]) HSP 1 Score: 112.849 bits (281), Expect = 1.940e-24 Identity = 68/237 (28.69%), Postives = 122/237 (51.48%), Query Frame = 1
Query: 1705 LDQNSKQIKAALD-WEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCC 2412
++ N + A L+ W++ + VQ N+ + +++D + S+ + IA Y++M Y +T+ +++ K S+ +GL VL+V +SV +G S L + +V+PFL L VGVD++F+L + E +K + E + + + G S+ L+S+S AFF + +PA++ FSL AA V+F+F + + + A+L +D R E R D+ CC
Sbjct: 374 INWNEDKAAAILEAWQRKYSEAVQQSVPVNSSQKVLTFTTTTLEDILKSFSDVSVIRIASGYLLMLAYACLTMLRWDCAK-----SQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAF---SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCC 602 HSP 2 Score: 59.6918 bits (143), Expect = 2.621e-8 Identity = 54/169 (31.95%), Postives = 92/169 (54.44%), Query Frame = 1
Query: 3310 YVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGP 3816
++F+EQY+ + L + + V L LV V L W A +I+ + L+ +FG M L GI ++A+ +V L+ ++GI VEF H+ A++ D R +RA L M + VL G + L G+++LA S+ ++F + + + G + ++ LPV LS+ GP
Sbjct: 1029 FLFWEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIV-LVLSLMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGD-RNKRAVLALEHMFAPVLDG-AFSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGP 1194
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Xenopus
Match: fosl1 (FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-6257957]) HSP 1 Score: 915.99 bits (2366), Expect = 0.000e+0 Identity = 515/1275 (40.39%), Postives = 770/1275 (60.39%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN-PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGYGG--------SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI--FIYLKKN------KYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTK-FKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPA-NFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI 3837
+ C+WYG+C S +K LNC Y+GPP L G L +LCP N ++CC+ QL TL+ L CP+C NF+ ++C LTC P Q F VT + G SI A+ Y + E F ++N+C +V S+N A+ +CG + C+ + + + PF I + + + MN C+ E+ G +CSCQDC SC P P + I G+D I+ IV+ F ++ ++ I + Y KKN D V +TP + S D+ G ++E +L + F +WG F R+ IV+ +++ ++ G+ ++TTDPVELWS P S AR+ K+YFD +FGPF+RTEQ+II + + + Y S ++ +GP + ++L +V L N I N++ + N L+DIC PL+P C + SV+ YFQN+ + L+ + D+F + A Y + C++ P ++ T + C G FGGP+FP+L GG+ D +NY ++TALVITF VNN +++++ A WE F+ V+N+S N +L IS++AERS++DEI+R+S++D+ T+ +SY +MF Y+++ LGQ + I VDSK++LG+ +LIVL SV CS+G +SY V +TLI++EV+PFLVLAVGVDN++I+VQ YQR + + T +Q+I R++ V PS+ LS+ +E++AFF G ++ MPAV+ FSL+A AV DFLLQIT I++L LD +R E R+D+LCCV D K L F K YAP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSYM++YF +L+TYL GPPVYF+V++G+NY ++ Q+ +CG +GCN SL+ +++ A+ N T I + +SW+DD+F W K CCR+Y + FC ASVVN++C +C + K +P + F +L FL++NP+ +C KGGHAAYG AV++ + + +GATYFMTYHTILK +D+ +A++ + IA ++T+ + +++V PYS+FYVFYEQYLT+ L V L V VT +LLG + + +++ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +H+ RA+ V R++RA + L MGSSV SGITLTK GI VL SKSQ+F+IFYFRMYL +V+ GAAH +IFLPV LS+ GP +N+ K+
Sbjct: 25 SSQHCVWYGECGNSTLEDKRLNCRYSGPPISLPEE-GHTLLQQLCPSLYY--GNNTVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPYQSEFLNVTQTEPFVGPSPQRANESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGKDVKDCNATNWIQYMFSKDNGQVPFTITPIFSDDPVTSMLPMNNATKGCD-EPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIFGLDAMAVIMWIVYVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDSTLAYS-VNSTPIAGEPSCCDRLGERLENFLRIGFTKWGSFCVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELWSDPHSQARQEKEYFDSHFGPFFRTEQLIITAPNSSVHNYSPYP-SGSDVPFGPPLDFNILAQVLELQNGIENLKAYYN--NETVMLKDICLAPLAPYNNNCTIFSVLNYFQNSFSVLNHSIQDDFYV-YADYHTHFLYCVRSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY-DDENYNNATALVITFPVNN-FRNDTEKLNRAKAWELEFIKFVENYS--NPNLSISFSAERSIEDEINRESKSDVTTVVISYALMFVYISLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVLAVGVDNIYIIVQRYQRDERLHDE---TLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAGMAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCVPGCKRNRGTD-------KPKSWLFLFFKKLYAPVLMKDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTYLHTGPPVYFVVEEGHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISNYTRIGYAPSSWIDDYFDWVKPQST--CCRIYNNTDQFCNASVVNASCLSCRSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKCGKGGHAAYGSAVDLLDSN------TNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNITDNMDIP---GKKYKVFPYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSVFSGITLTKFVGIGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLGPQVNKAKV 1265
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Xenopus
Match: fosl1 (FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-6257957]) HSP 1 Score: 909.057 bits (2348), Expect = 0.000e+0 Identity = 514/1271 (40.44%), Postives = 766/1271 (60.27%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN-PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGYGG--------SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI--FIYLKKN------KYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTK-FKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPA-NFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALN 3825
+ C+WYG+C S +K LNC Y+GPP L G L +LCP N ++CC+ QL TL+ L CP+C NF+ ++C LTC P Q F VT + G SI A+ Y + E F ++N+C +V S+N A+ +CG + C+ + + + PF I + + + MN C+ E+ G +CSCQDC SC P P + I G+D I+ IV+ F ++ ++ I + Y KKN D V +TP + S D+ G ++E +L + F +WG F R+ IV+ +++ ++ G+ ++TTDPVELWS P S AR+ K+YFD +FGPF+RTEQ+II + + + Y S ++ +GP + ++L +V L N I N++ + N L+DIC PL+P C + SV+ YFQN+ + L+ + D+F + A Y + C++ P ++ T + C G FGGP+FP+L GG+ D +NY ++TALVITF VNN +++++ A WE F+ V+N+S N +L IS++AERS++DEI+R+S++D+ T+ +SY +MF Y+++ LGQ + I VDSK++LG+ +LIVL SV CS+G +SY V +TLI++EV+PFLVLAVGVDN++I+VQ YQR + + T +Q+I R++ V PS+ LS+ +E++AFF G ++ MPAV+ FSL+A AV DFLLQIT I++L LD +R E R+D+LCCV P K L F K YAP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSYM++YF +L+TYL GPPVYF+V++G+NY ++ Q+ +CG +GCN SL+ +++ A+ N T I + +SW+DD+F W K CCR+Y + FC ASVVN++C +C + K +P + F +L FL++NP+ +C KGGHAAYG AV++ + + +GATYFMTYHTILK +D+ +A++ + IA ++T+ + +++V PYS+FYVFYEQYLT+ L V L V VT +LLG + + +++ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +H+ RA+ V R++RA + L MGSSV SGITLTK GI VL SKSQ+F+IFYFRMYL +V+ GAAH +IFLPV LS+ G LN
Sbjct: 28 SSQHCVWYGECGNSTLEDKRLNCRYSGPPISLPEE-GHTLLQQLCPSLYY--GNNTVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPYQSEFLNVTQTEPFVGPSPQRANESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGKDVKDCNATNWIQYMFSKDNGQVPFTITPIFSDDPVTSMLPMNNATKGCD-EPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIFGLDAMAVIMWIVYVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDSTLAYS-VNSTPIAGEPSCCDRLGERLENFLRIGFTKWGSFCVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELWSDPHSQARQEKEYFDSHFGPFFRTEQLIITAPNSSVHNYSPYP-SGSDVPFGPPLDFNILAQVLELQNGIENLKAYYN--NETVMLKDICLAPLAPYNNNCTIFSVLNYFQNSFSVLNHSIQDDFYV-YADYHTHFLYCVRSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY-DDENYNNATALVITFPVNN-FRNDTEKLNRAKAWELEFIKFVENYS--NPNLSISFSAERSIEDEINRESKSDVTTVVISYALMFVYISLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVLAVGVDNIYIIVQRYQRDERLHDE---TLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAGMAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCV-------PGCKRNRGTDKPKSWLFLFFKKLYAPVLMKDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTYLHTGPPVYFVVEEGHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISNYTRIGYAPSSWIDDYFDWVKPQST--CCRIYNNTDQFCNASVVNASCLSCRSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKCGKGGHAAYGSAVDLLDSN------TNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNITDNMDIP---GKKYKVFPYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSVFSGITLTKFVGIGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLGENLN 1264
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Xenopus
Match: fosl1 (FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-6257957]) HSP 1 Score: 906.746 bits (2342), Expect = 0.000e+0 Identity = 513/1280 (40.08%), Postives = 768/1280 (60.00%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN-PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGYGG--------SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI--FIYLKKN------KYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTK-FKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPA-NFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK 3852
+ C+WYG+C S +K LNC Y+GPP L G L +LCP N ++CC+ QL TL+ L CP+C NF+ ++C LTC P Q F VT + G SI A+ Y + E F ++N+C +V S+N A+ +CG + C+ + + + PF I + + + MN C+ E+ G +CSCQDC SC P P + I G+D I+ IV+ F ++ ++ I + Y KKN D V +TP + S D+ G ++E +L + F +WG F R+ IV+ +++ ++ G+ ++TTDPVELWS P S AR+ K+YFD +FGPF+RTEQ+II + + + Y S ++ +GP + ++L +V L N I N++ + N L+DIC PL+P C + SV+ YFQN+ + L+ + D+F + A Y + C++ P ++ T + C G FGGP+FP+L GG+ D +NY ++TALVITF VNN +++++ A WE F+ V+N+S N +L IS++AERS++DEI+R+S++D+ T+ +SY +MF Y+++ LGQ + I VDSK++LG+ +LIVL SV CS+G +SY V +TLI++EV+PFLVLAVGVDN++I+VQ YQR + + T +Q+I R++ V PS+ LS+ +E++AFF G ++ MPAV+ FSL+A AV DFLLQIT I++L LD +R E R+D+LCCV D K L F K YAP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSYM++YF +L+TYL GPPVYF+V++G+NY ++ Q+ +CG +GCN SL+ +++ A+ N T I + +SW+DD+F W K CCR+Y + FC ASVVN++C +C + K +P + F +L FL++NP+ +C KGGHAAYG AV++ + + +GATYFMTYHTILK +D+ +A++ + IA ++T+ + +++V PYS+FYVFYEQYLT+ L V L V VT +LLG + + +++ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +H+ RA+ V R++RA + L MGSSV SGITLTK GI VL SKSQ+F+IFYFRMYL +V+ GAAH +IFLPV LS+ G L + ++
Sbjct: 19 SSQHCVWYGECGNSTLEDKRLNCRYSGPPISLPEE-GHTLLQQLCPSLYY--GNNTVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPYQSEFLNVTQTEPFVGPSPQRANESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGKDVKDCNATNWIQYMFSKDNGQVPFTITPIFSDDPVTSMLPMNNATKGCD-EPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIFGLDAMAVIMWIVYVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDSTLAYS-VNSTPIAGEPSCCDRLGERLENFLRIGFTKWGSFCVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELWSDPHSQARQEKEYFDSHFGPFFRTEQLIITAPNSSVHNYSPYP-SGSDVPFGPPLDFNILAQVLELQNGIENLKAYYN--NETVMLKDICLAPLAPYNNNCTIFSVLNYFQNSFSVLNHSIQDDFYV-YADYHTHFLYCVRSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY-DDENYNNATALVITFPVNN-FRNDTEKLNRAKAWELEFIKFVENYS--NPNLSISFSAERSIEDEINRESKSDVTTVVISYALMFVYISLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVLAVGVDNIYIIVQRYQRDERLHDE---TLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAGMAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCVPGCKRNRGTD-------KPKSWLFLFFKKLYAPVLMKDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTYLHTGPPVYFVVEEGHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISNYTRIGYAPSSWIDDYFDWVKPQST--CCRIYNNTDQFCNASVVNASCLSCRSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKCGKGGHAAYGSAVDLLDSN------TNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNITDNMDIP---GKKYKVFPYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSVFSGITLTKFVGIGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLGEFLGTAAFIGDER 1264
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Xenopus
Match: fosl1 (FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-6257957]) HSP 1 Score: 900.197 bits (2325), Expect = 0.000e+0 Identity = 512/1274 (40.19%), Postives = 766/1274 (60.13%), Query Frame = 1
Query: 100 KNDKCIWYGQCDKSN-PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGYGG--------SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI--FIYLKKN------KYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTK-FKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVT---YISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPA-NFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALN 3825
+ C+WYG+C S +K LNC Y+GPP L G L +LCP N ++CC+ QL TL+ L CP+C NF+ ++C LTC P Q F VT + G SI A+ Y + E F ++N+C +V S+N A+ +CG + C+ + + + PF I + + + MN C+ E+ G +CSCQDC SC P P + I G+D I+ IV+ F ++ ++ I + Y KKN D V +TP + S D+ G ++E +L + F +WG F R+ IV+ +++ ++ G+ ++TTDPVELWS P S AR+ K+YFD +FGPF+RTEQ+II + + + Y S ++ +GP + ++L +V L N I N++ + N L+DIC PL+P C + SV+ YFQN+ + L+ + D+F + A Y + C++ P ++ T + C G FGGP+FP+L GG+ D +NY ++TALVITF VNN +++++ A WE F+ V+N+S N +L IS++AERS++DEI+R+S++D+ T+ +SY +MF Y+++ LGQ + I VDSK++LG+ +LIVL SV CS+G +SY V +TLI++EV+PFLVLAVGVDN++I+VQ YQR + + T +Q+I R++ V PS+ LS+ +E++AFF G ++ MPAV+ FSL+A AV DFLLQIT I++L LD +R E R+D+LCCV D K L F K YAP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSYM++YF +L+TYL GPPVYF+V++G+NY ++ Q+ +CG +GCN SL+ +++ A+ ++ I + +SW+DD+F W K CCR+Y + FC ASVVN++C +C + K +P + F +L FL++NP+ +C KGGHAAYG AV++ + + +GATYFMTYHTILK +D+ +A++ + IA ++T+ + +++V PYS+FYVFYEQYLT+ L V L V VT +LLG + + +++ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +H+ RA+ V R++RA + L MGSSV SGITLTK GI VL SKSQ+F+IFYFRMYL +V+ GAAH +IFLPV LS+ G LN
Sbjct: 19 SSQHCVWYGECGNSTLEDKRLNCRYSGPPISLPEE-GHTLLQQLCPSLYY--GNNTVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPYQSEFLNVTQTEPFVGPSPQRANESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGKDVKDCNATNWIQYMFSKDNGQVPFTITPIFSDDPVTSMLPMNNATKGCD-EPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIFGLDAMAVIMWIVYVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDSTLAYS-VNSTPIAGEPSCCDRLGERLENFLRIGFTKWGSFCVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELWSDPHSQARQEKEYFDSHFGPFFRTEQLIITAPNSSVHNYSPYP-SGSDVPFGPPLDFNILAQVLELQNGIENLKAYYN--NETVMLKDICLAPLAPYNNNCTIFSVLNYFQNSFSVLNHSIQDDFYV-YADYHTHFLYCVRSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY-DDENYNNATALVITFPVNN-FRNDTEKLNRAKAWELEFIKFVENYS--NPNLSISFSAERSIEDEINRESKSDVTTVVISYALMFVYISLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVLAVGVDNIYIIVQRYQRDERLHDE---TLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAGMAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCVPGCKRNRGTD-------KPKSWLFLFFKKLYAPVLMKDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTYLHTGPPVYFVVEEGHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISTMSDRFAIGYAPSSWIDDYFDWVKPQST--CCRIYNNTDQFCNASVVNASCLSCRSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKCGKGGHAAYGSAVDLLDSN------TNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNITDNMDIP---GKKYKVFPYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSVFSGITLTKFVGIGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLGENLN 1258
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Xenopus
Match: fosl1 (FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-6257957]) HSP 1 Score: 897.501 bits (2318), Expect = 0.000e+0 Identity = 510/1272 (40.09%), Postives = 765/1272 (60.14%), Query Frame = 1
Query: 94 HCKNDKCIWYGQCDKSN-PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGYGG--------SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYI--FIYLKKN------KYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTK-FKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVT---YISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPA-NFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCG 3813
+ + C+WYG+C S +K LNC Y+GPP L G L +LCP N ++CC+ QL TL+ L CP+C NF+ ++C LTC P Q F VT + G SI A+ Y + E F ++N+C +V S+N A+ +CG + C+ + + + PF I + + + MN C+ E+ G +CSCQDC SC P P + I G+D I+ IV+ F ++ ++ I + Y KKN D V +TP + S D+ G ++E +L + F +WG F R+ IV+ +++ ++ G+ ++TTDPVELWS P S AR+ K+YFD +FGPF+RTEQ+II + + + Y S ++ +GP + ++L +V L N I N++ + N L+DIC PL+P C + SV+ YFQN+ + L+ + D+F + A Y + C++ P ++ T + C G FGGP+FP+L GG+ D +NY ++TALVITF VNN +++++ A WE F+ V+N+S N +L IS++AERS++DEI+R+S++D+ T+ +SY +MF Y+++ LGQ + I VDSK++LG+ +LIVL SV CS+G +SY V +TLI++EV+PFLVLAVGVDN++I+VQ YQR + + T +Q+I R++ V PS+ LS+ +E++AFF G ++ MPAV+ FSL+A AV DFLLQIT I++L LD +R E R+D+LCCV D K L F K YAP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSYM++YF +L+TYL GPPVYF+V++G+NY ++ Q+ +CG +GCN SL+ +++ A+ ++ I + +SW+DD+F W K CCR+Y + FC ASVVN++C +C + K +P + F +L FL++NP+ +C KGGHAAYG AV++ + + +GATYFMTYHTILK +D+ +A++ + IA ++T+ + +++V PYS+FYVFYEQYLT+ L V L V VT +LLG + + +++ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +H+ RA+ V R++RA + L MGSSV SGITLTK GI VL SKSQ+F+IFYFRMYL +V+ GAAH +IFLPV LS+ G
Sbjct: 6 YVSSQHCVWYGECGNSTLEDKRLNCRYSGPPISLPEE-GHTLLQQLCPSLYY--GNNTVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPYQSEFLNVTQTEPFVGPSPQRANESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGKDVKDCNATNWIQYMFSKDNGQVPFTITPIFSDDPVTSMLPMNNATKGCD-EPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIFGLDAMAVIMWIVYVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDSTLAYS-VNSTPIAGEPSCCDRLGERLENFLRIGFTKWGSFCVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELWSDPHSQARQEKEYFDSHFGPFFRTEQLIITAPNSSVHNYSPYP-SGSDVPFGPPLDFNILAQVLELQNGIENLKAYYN--NETVMLKDICLAPLAPYNNNCTIFSVLNYFQNSFSVLNHSIQDDFYV-YADYHTHFLYCVRSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY-DDENYNNATALVITFPVNN-FRNDTEKLNRAKAWELEFIKFVENYS--NPNLSISFSAERSIEDEINRESKSDVTTVVISYALMFVYISLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVLAVGVDNIYIIVQRYQRDERLHDE---TLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAGMAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCVPGCKRNRGTD-------KPKSWLFLFFKKLYAPVLMKDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTYLHTGPPVYFVVEEGHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISTMSDRFAIGYAPSSWIDDYFDWVKPQST--CCRIYNNTDQFCNASVVNASCLSCRSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKCGKGGHAAYGSAVDLLDSN------TNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNITDNMDIP---GKKYKVFPYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSVFSGITLTKFVGIGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLG 1243
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Mouse
Match: Npc1 (NPC intracellular cholesterol transporter 1 [Source:MGI Symbol;Acc:MGI:1097712]) HSP 1 Score: 936.406 bits (2419), Expect = 0.000e+0 Identity = 537/1273 (42.18%), Postives = 773/1273 (60.72%), Query Frame = 1
Query: 103 NDKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGY--------GGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDA-TSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY------DKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARR--CLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKF-KEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIW-SKQSGNPPCCRLYP-DGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKK 3834
+ C+WYG+C + +K NC Y+GPPKPL G+ + +LCP N SLCC+ QL TL L CP+C N + L+C LTC P+Q F VT Y +++ + Y + ++F ++N+C +V S+N A+ +CG C+ + + + + APF I + ++ M CN + E G CSCQDC C P P P + I G+D I+ + + AF + + ++ + +Y D + + + S D GA + L F +WG F R C+I S+ I V S G++ +VTT+PVELWS+P S AR K+YFD++FGPF+RTEQ+II + + + Y A ++ +GP N ++L +V L I+ + + N L+DIC PLSP + C +MSV+ YFQN+ LD V D+F + A Y + C++ P ++ T C G FGGPVFP+L GG+ D +NY ++TALVITF VNN + ++++++ A WEK F++ V+N+ N +L IS+TAERS++DE++R+S +D+FT+ +SY++MF Y+++ LG + ++ VDSK++LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FILVQTYQR DE + L +Q++ R++ +V P+M LSS SE+ AFF G ++ MPAV FSL+A AVL DFLLQIT +++L LD KR E +D+LCCVR + A L F ++AP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSY+I+YF +LA YL GPPVYF++++GYNY S QNM+CG GC+ SL+ Q+F A++ T + + +SW+DD+F W S QS CCRLY FC ASV++ TC C P K RP K F +L FL++NP+ +C KGGHAAYG AVNI D IGATYFMTYHTILKT +DYT+A+K + IA+++TE +++ + + V PYSVFYVFYEQYLT+ L V LG + LVT V+LG + + +I+ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HI RA+ + +R+ RA E L MGSSV SGITLTK GGI+VLAF+KSQ+F+IFYFRMYL +V+ GA H +IFLPV LS+ GP++N+ K
Sbjct: 22 SQSCVWYGECGIATGDKRYNCKYSGPPKPLPK-DGYDLVQELCP--GLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTG-PCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFIT--VCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGA-DVPFGPPLNKEILHQVLDL--QIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYI-YADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGY-DDQNYNNATALVITFPVNNYYN-DTERLQRAWAWEKEFISFVKNYK--NPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQR-DERLQEETL--DQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHAS-------ESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSS---CCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDD------TYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRS---KGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 1258
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Mouse
Match: Npc1l1 (NPC1 like intracellular cholesterol transporter 1 [Source:MGI Symbol;Acc:MGI:2685089]) HSP 1 Score: 741.88 bits (1914), Expect = 0.000e+0 Identity = 473/1260 (37.54%), Postives = 718/1260 (56.98%), Query Frame = 1
Query: 187 PLNNATG--FQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV------DTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINY---------LNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNK-YDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSP---DYEKCAVMSVMQYFQNNITQLDRIVTDEFN--LPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD-LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPML---FKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPASVVNSTC-NNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLE 3861
P + TG L ++CP+ + CC+T QL++LD LS + CP C NF+ ++C TC P+Q F+ V D G ++ A +F + + SC V + +A S A+ ++CG C+ + GD + AP I + + +K ++ + PCN + GED ACSCQDC ASCP PPP +F + + GW+ ++ I+F A F+++ + +++ + N+ +K G+ P P S L +F WG VA L VL++ I+ + LS+G+ ++TTDPVELWS+P S AR+ K + DE+FGPF+RT QI + K+R+ + + + + +N + + ++DLL+ + L + +++V+S L+DIC+ PL P C V S++QYFQNN T L N + + D + C P K T C D+G PVFP+LA GG+ +Y+++ AL+ITF +NN + + A L WE+AFL +Q+F + D I+++AERS++DEI+R + DL A+SY+I+F Y+++ LG Y+ ++ VDSK TLGL V +VL +V ++GF+SYL VP +L+I++VVPFLVLAVG DN+FI V YQR + E I R + V PSMLL SLSE++ FF G +T MPAV+ F+L + A++FDFLLQ+T +A+L LD+KR EA R DV+CC N+ P + G+L F K Y P L F PV L+ + G NL+ + I V L+Q L++PKDSY+I+YF L YL VGPPVYF GYN+ +E N IC ++GC SL ++ AS+ PN +Y++ + +SW+DDF W S + CCR+Y G FCP++ + C NC RP + F YL +FL + P+++CPKGG AAY +VN+ + +I A+ FM YH L+ D+TEAL+ S +AA++T +L+ G FEV PY++ VFY+QYLTV + L +C +V ++LLGLD ++ ++ II+I+ G M +WGI NA+S++NLV A+G+SVEF++HI R++ V TR+ERA++ + MGS+V +G+ +T GI++L F+++QL QIF+FR+ L I + G H ++FLPV LS+ GP +N+ ++E+K E
Sbjct: 61 PARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSENFVSIHCHNTCSPDQSLFINVTRVVQRDPGQLPAVVAYEAFYQRSFAEKAYESCSRVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGKITPCNESQGEDSA-ACSCQDCAASCPVIPPPPALRPSFYMGRMPGWLALI-IIFTAVFVLLSVVLVYLRVASNRNKNKTAGSQEAPNLPRKRRFSP--------HTVLGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKNRSSYKYDSLLLGPKN--FSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAPLKPHNTSLTDCCVNSLLQYFQNNHTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALALSCIADYGAPVFPFLAVGGY-QGTDYSEAEALIITFSINNYPADDPRMAHAKL-WEEAFLKEMQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQR---EAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSSRNLPPPK--------QKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNIS---VGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSS--CCRIYTRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSDG-------QIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATE 1283
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373]) HSP 1 Score: 109.383 bits (272), Expect = 7.228e-24 Identity = 66/237 (27.85%), Postives = 123/237 (51.90%), Query Frame = 1
Query: 1705 LDQNSKQIKAALD-WEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCC 2412
++ N + A L+ W++ ++ VV N+ + ++ D + S+ + +A Y++M Y +T+ +++ K S+ +GL VL+V +SV +G S + + +V+PFL L VGVD++F+L + E +K + E + + + G S+ L+S+S AFF + +PA++ FSL AA V+F+F + + + A+L +D R E R+D+ CC
Sbjct: 319 INWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF---SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373]) HSP 1 Score: 110.538 bits (275), Expect = 1.059e-23 Identity = 66/237 (27.85%), Postives = 123/237 (51.90%), Query Frame = 1
Query: 1705 LDQNSKQIKAALD-WEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCC 2412
++ N + A L+ W++ ++ VV N+ + ++ D + S+ + +A Y++M Y +T+ +++ K S+ +GL VL+V +SV +G S + + +V+PFL L VGVD++F+L + E +K + E + + + G S+ L+S+S AFF + +PA++ FSL AA V+F+F + + + A+L +D R E R+D+ CC
Sbjct: 371 INWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF---SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 599 HSP 2 Score: 65.855 bits (159), Expect = 4.520e-10 Identity = 70/228 (30.70%), Postives = 116/228 (50.88%), Query Frame = 1
Query: 3133 KPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGP 3816
+P+E F Y L+ SD+ EA++ I + T +LG S+ P ++F+EQY+++ L + + V L LV V L W A +I+ + L+ +FG M L GI ++A+ +V L+ ++GI VEF H+ A++ D + RA L M + VL G T L G+++LA S+ ++F + + + G + ++ LPV LSF GP
Sbjct: 953 EPIEYAQ--FPFYLNGLRDTSDFVEAIEKVRVICNNYT-----SLGLSS----YPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIV-MVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGD-KNHRAMLALEHMFAPVLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGP 1166
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Mouse
Match: Ptchd3 (patched domain containing 3 [Source:MGI Symbol;Acc:MGI:1921925]) HSP 1 Score: 109.768 bits (273), Expect = 1.235e-23 Identity = 98/410 (23.90%), Postives = 193/410 (47.07%), Query Frame = 1
Query: 1552 PTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNT--DLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEA------------MRVDVLCCVRMNNVVTP--VDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLS-VGPPVYFIVKDGYNY 2730
P + PT+ + G FGG V + G + +S A+ + + + ++S++ +A W FL+ + + T ++ + Y + S Q E + S+T + L+YI++ + ++ + + I+ +K+ + + V V +SV G +L VP +I+ PFL+L VGVD++FI++ +Q+ +S + + ++++ SKV S+ +++++ LAF+ G+ + +V+ F +Y T +LF + IT AV+ LD KR A + CCV +++ D P ++ F ++ P L + +F+VV+ ++ + + ++ + L+ + DSY+ YF+ Y S GP V IV + NY
Sbjct: 242 PIHNTPTQLIYLA-GFFGGNVLGQMT----GKSQRLVESRAMRLLYYLKTEDPEDSERSQA---WLTHFLDHFNDMKSSLTLEEIEVVYFSSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLDCIR-----NKMCVAVFGVFSVAMSVVSGFGLMLHLGVPFVIIVANS-PFLILGVGVDDMFIMISAWQK-----TSLSESIRERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKREVAWSRWLEKPDQKYSSLKKSCCVPFGSLIDKHGEDNHP---------MNLFFRDYFGPFLTTSKAKFIVVLLYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTESVNY 623 HSP 2 Score: 83.9593 bits (206), Expect = 9.197e-16 Identity = 46/127 (36.22%), Postives = 81/127 (63.78%), Query Frame = 1
Query: 3427 TLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSF 3807
+L + F I ++ + GFM W + ++++SM+NLV+ IG S +F AHI A+V + +++ E L +G VL ++ + G+ VL+ +K+ +F+ F+ M+L ++ FGAAH +IF+PVFL+F
Sbjct: 781 SLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSTEPSVNKKSIEALYLLGYPVLQS-AISTIIGVCVLSAAKAYIFRTFFKIMFL-VMFFGAAHGLIFIPVFLTF 905
BLAST of Niemann-Pick disease, type C1 vs. UniProt/SwissProt
Match: sp|O35604|NPC1_MOUSE (NPC intracellular cholesterol transporter 1 OS=Mus musculus OX=10090 GN=Npc1 PE=1 SV=2) HSP 1 Score: 936.406 bits (2419), Expect = 0.000e+0 Identity = 537/1273 (42.18%), Postives = 773/1273 (60.72%), Query Frame = 1
Query: 103 NDKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGY--------GGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDA-TSNAPFQI------NYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY------DKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARR--CLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKF-KEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIW-SKQSGNPPCCRLYP-DGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKK 3834
+ C+WYG+C + +K NC Y+GPPKPL G+ + +LCP N SLCC+ QL TL L CP+C N + L+C LTC P+Q F VT Y +++ + Y + ++F ++N+C +V S+N A+ +CG C+ + + + + APF I + ++ M CN + E G CSCQDC C P P P + I G+D I+ + + AF + + ++ + +Y D + + + S D GA + L F +WG F R C+I S+ I V S G++ +VTT+PVELWS+P S AR K+YFD++FGPF+RTEQ+II + + + Y A ++ +GP N ++L +V L I+ + + N L+DIC PLSP + C +MSV+ YFQN+ LD V D+F + A Y + C++ P ++ T C G FGGPVFP+L GG+ D +NY ++TALVITF VNN + ++++++ A WEK F++ V+N+ N +L IS+TAERS++DE++R+S +D+FT+ +SY++MF Y+++ LG + ++ VDSK++LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FILVQTYQR DE + L +Q++ R++ +V P+M LSS SE+ AFF G ++ MPAV FSL+A AVL DFLLQIT +++L LD KR E +D+LCCVR + A L F ++AP+L K +R +VV FVG F+++ ++ + + L+Q LSMP DSY+I+YF +LA YL GPPVYF++++GYNY S QNM+CG GC+ SL+ Q+F A++ T + + +SW+DD+F W S QS CCRLY FC ASV++ TC C P K RP K F +L FL++NP+ +C KGGHAAYG AVNI D IGATYFMTYHTILKT +DYT+A+K + IA+++TE +++ + + V PYSVFYVFYEQYLT+ L V LG + LVT V+LG + + +I+ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HI RA+ + +R+ RA E L MGSSV SGITLTK GGI+VLAF+KSQ+F+IFYFRMYL +V+ GA H +IFLPV LS+ GP++N+ K
Sbjct: 22 SQSCVWYGECGIATGDKRYNCKYSGPPKPLPK-DGYDLVQELCP--GLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSILGMEPMRNATKGCNESVDEVTG-PCSCQDCSIVCGPKPQPPPPPMPWRIWGLDAMYVIMWVTYVAFLFVFFGALLAVWCHRRRYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMFTKWGAFCVRNPTCIIFFSLAFIT--VCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGA-DVPFGPPLNKEILHQVLDL--QIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYI-YADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGY-DDQNYNNATALVITFPVNNYYN-DTERLQRAWAWEKEFISFVKNYK--NPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQR-DERLQEETL--DQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQGSHAS-------ESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSS---CCRLYNVTHQFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDD------TYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMRS---KGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 1258
BLAST of Niemann-Pick disease, type C1 vs. UniProt/SwissProt
Match: sp|P56941|NPC1_PIG (NPC intracellular cholesterol transporter 1 OS=Sus scrofa OX=9823 GN=NPC1 PE=2 SV=1) HSP 1 Score: 935.636 bits (2417), Expect = 0.000e+0 Identity = 547/1281 (42.70%), Postives = 781/1281 (60.97%), Query Frame = 1
Query: 103 NDKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGY--------GGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDA-TSNAPFQINYL------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY-DKDY----GNGIVPATPEVDDISTF--DKCGAKVEAYLTLWFYRWGMFVARR--CLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKF-KEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYS-GILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLG-NSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK 3852
+ C+WYG+C ++ +K NC Y+GPPKPL G+ + +LCP + N SLCC+ QL TL L CP+C N + L+C LTC P Q F VT Y +++ + Y + E F ++N+C +V S+N A+ +CG + C+ + + + + APF I + + ++ MN C+ + E G CSCQDC C P P P + ILG+D I+ + AF ++ + ++ + +Y +Y GN I + D F D GA E L F +WG F R C++ S+ I+A S G++ +VTTDPV+LWS+P S ARR K+YFD +FGPF+R EQ+II + + Y A ++ +GP + D+L +V L I N+ + N L+DIC PLSP + C ++SV+ YFQN+ + LD V D F A Y + C++ P ++ + C G FGGPVFP+L GG+ D +NY ++TALVITF VNN + ++++++ A WE F+N V+N+ N +L IS+ AERS++DE++R+S +DLFTI +SY IMF Y++I LG + ++ VDSK++LG+ +LIVL SV CS+G +SY+ VP+TLI++EV+PFLVLAVGVDN+FILVQTYQR DE + L +Q++ RV+ +V PSM LSS SE++AFF G ++ +PAV FSL+A AVL DFLLQIT +++L LD KR E R+DV+CCV+ A A V+ S L F YAP+L K +R +V+ FVG F+++ ++ + + L+Q LSMP DSY+++YF +L+ YL GPPVYF+V++G+NY S QNM+CG GCN SL+ Q+F A+Q N T I + +SW+DD+F W K + CCR+Y FC ASVV+ TC C P K RP + F +L FL++NP+ +C KGGHAAY AVNI +GATYFMTYHT+L+ +D+ +A++ + IA+++T T+G ++ + V PYSVFYVFYEQYLTV LGV LG + LVT VL+G + AT+I+ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HI RA+ + +R++RA E L MGSSV SGITLTK GGI+VLAF+KSQ+FQIFYFRMYL IV+ GA H +IFLPV LS+ GP++N+ K + ++
Sbjct: 22 SQSCVWYGECGIASGDKRYNCRYSGPPKPLPE-DGYDLVQELCPGF--FFGNVSLCCDVQQLRTLKDNLQLPLQFLSRCPSCFYNLMNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELEYYVGETFANAMYNACRDVEAPSSNEKALGLLCGREAQACNATNWIEYMFNKDNGQAPFTITPIFSDLPTHGMEPMNNATKGCDESVDEVTG-PCSCQDCSIVCGPKPQPPPPPVPWRILGLDAMYVIMWSSYMAFLIVFFGAFFAVWCYRKRYFVSEYTPIDGN-IAFSVNSSDKGQAFCCDPLGAAFERGLRRLFAQWGAFCVRHPGCVVFFSLAFIVA--CSSGLVFIRVTTDPVDLWSAPGSQARREKEYFDTHFGPFFRMEQLIIRATNNQSHIYHPYPAGA-DVPFGPPLSRDILHQVLDLQTAIENIT--ASYNNETVTLQDICLAPLSPYNKNCTILSVLNYFQNSHSVLDHQVGD-FFFVYADYHTHFLYCVRAPASLNDASLLHDPCLGTFGGPVFPWLVLGGY-DDQNYNNATALVITFPVNNYYN-DTEKLQRAQAWESEFINFVKNYK--NPNLTISFMAERSIEDELNRESNSDLFTILISYAIMFLYISIALGHIKSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYIGVPLTLIVIEVIPFLVLAVGVDNIFILVQTYQR-DERLQGETL--DQQLGRVLGEVAPSMFLSSFSETVAFFLGGLSVVPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNRLDVVCCVQ--------GAEDGAGVQASESCLFRFFKNSYAPLLLKDWMRPIVIAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVMDYFQSLSRYLHAGPPVYFVVEEGHNYTSLKGQNMVCGGLGCNNDSLVQQIFTAAQLDNYTRIGFAPSSWIDDYFDWIKPQSS--CCRVYNSTDQFCNASVVDPTCIRCRPLTSEGKQRPQGEDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILGNGSG------VGATYFMTYHTVLQASADFIDAMQKARLIASNITR----TMGLEASSYRVFPYSVFYVFYEQYLTVIDDTIFNLGVSLGAIFLVTVVLMGCELWATVIMCVTIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTLSTKGSRVDRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAIVLLGATHGLIFLPVLLSYIGPSINKAKSLATQE 1264
BLAST of Niemann-Pick disease, type C1 vs. UniProt/SwissProt
Match: sp|O15118|NPC1_HUMAN (NPC intracellular cholesterol transporter 1 OS=Homo sapiens OX=9606 GN=NPC1 PE=1 SV=2) HSP 1 Score: 929.472 bits (2401), Expect = 0.000e+0 Identity = 544/1277 (42.60%), Postives = 775/1277 (60.69%), Query Frame = 1
Query: 103 NDKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNF--VTVDTGY--------GGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDA-TSNAPFQINYL------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY------DKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARR--CLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFT----WINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKF-KEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRL-YPDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLG-NSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKK 3834
+ C+WYG+C + +K NC Y+GPPKPL G+ + +LCP + N SLCC+ QL TL L CP+C N + L+C LTC P Q F VT Y +++ + Y + ++F ++N+C +V S+N A+ +CG + C+ + + + + APF I + + ++ MN C+ + E CSCQDC C P P P +TILG+D I+ I + AF ++ + ++ + +Y D + + S D A E L F RWG F R C+I S+ I A S G++ +VTT+PV+LWS+PSS AR K+YFD++FGPF+RTEQ+II R P T + Y S ++ +GP +I +L +V L I N+ + N L+DIC PLSP C ++SV+ YFQN+ + LD D+F A Y + C++ P ++ T + C G FGGPVFP+L GG+ D +NY ++TALVITF VNN + ++++++ A WEK F+N V+N+ N +L IS+TAERS++DE++R+S++D+FT+ +SY IMF Y+++ LG + +++ VDSKV+LG+ +LIVL SV CS+G +SY+ +P+TLI++EV+PFLVLAVGVDN+FILVQ YQR DE + L +Q++ RV+ +V PSM LSS SE++AFF G ++ MPAV FSL+A AV DFLLQIT +++L LD KR E R+D+ CCVR T V A L F Y+P+L K +R +V+ FVG F+++ ++ + + L+Q LSMP DSYM++YF +++ YL GPPVYF++++G++Y S QNM+CG GCN SL+ Q+F A+Q N T I + +SW+DD+F W K + CCR+ FC ASVV+ C C P K RP F +L FL++NP+ +C KGGHAAY AVNI H +GATYFMTYHT+L+T +D+ +ALK + IA++VTE T+G N + + V PYSVFYVFYEQYLT+ LGV LG + LVT VLLG + + +I+ I +++ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HI RA+ V +R+ERA E L MGSSV SGITLTK GGI+VLAF+KSQ+FQIFYFRMYL +V+ GA H +IFLPV LS+ GP++N+ K
Sbjct: 22 SQSCVWYGECGIAYGDKRYNCEYSGPPKPLPK-DGYDLVQELCPGF--FFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTA-PCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITA--CSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLII----RAPLTDKHIYQPYP-SGADVPFGPPLDIQILHQVLDLQIAIENIT--ASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDF-FVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY-DDQNYNNATALVITFPVNNYYN-DTEKLQRAQAWEKEFINFVKNYK--NPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQR-DERLQGETL--DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQAS-------ESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSS--CCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL----LGHG-TRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTE----TMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 1259
BLAST of Niemann-Pick disease, type C1 vs. UniProt/SwissProt
Match: sp|Q6T3U3|NPCL1_RAT (NPC1-like intracellular cholesterol transporter 1 OS=Rattus norvegicus OX=10116 GN=Npc1l1 PE=1 SV=1) HSP 1 Score: 770 bits (1987), Expect = 0.000e+0 Identity = 477/1291 (36.95%), Postives = 729/1291 (56.47%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTG-------PPKPLNNATG--FQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFV----TVDTGYGGSIQAVTYNLNENFYQGLF-----NSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYL---------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNK-YDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSP---DYEKCAVMSVMQYFQNNITQLDRIVTDEFN--LPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTD-LHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFV---GWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPASVVNSTC-NNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQK 3849
C +Y +C K N L+ T P + TG L ++CP+ CC+T QLL+L+ +S + CP C NF+ L+C TC P+Q F+ V+ G G V Y E FYQ F SC V + +A S A+ ++CG C+ + GD + AP I + + ++ +N + PCN + G DD CSCQDC ASCP PPP+ +F + + GW+ ++ I+F A F+++ ++ + + + N+ +K G P P +S L +F WG VA L VL++ I+ + L+ G+ ++TTDPVELWS+P S AR+ K + DE+FGPF+RT QI + ++R+ + + + + ++N + + ++D L + L + +++V+S L+DIC+ PL+P C V S++QYFQNN T L N + + D + C P K T C D+G PVFP+LA GG+ +Y+++ AL+ITF +NN + + +A L WE+AFL +++F +D ++++AERS++DEI+R + DL A+SYII+F Y+++ LG Y+ ++ V+SK TLGL V++VL +V ++GF+SYL VP +L+I++VVPFLVLAVG DN+FI V YQR + E I R + V PSMLL SLSE++ FF G +T MPAV+ F+L + A++ DFLLQ+T +A+L LD+KR EA R DVLCC + P + G+L F K YAP L +R +V++ F+ G NL+ + I+ V L+Q+L++PKDSY+I+YF L YL VGPPVYF+ G+N+ SE N C ++GC SL ++ AS+ P+ +Y++ + +SW+DDF W S + CCRLY G FCP++ + C NC RP A+ F YL +FL + P+++CPKGG AAY +VN+ + ++ A+ FM YH L+ D+TEAL+ S +AA++T L+ G FEV PY++ VFY+QYLTV + L +C +V ++LLGLD + ++ II+I+ G M +WGI NA+S++NLV A+G+SVEF++HI R++ V TR+ERA++ V MGS+V +G+ +T GI++L F+++QL QIF+FR+ L I + G H ++FLPV LS+ GP +N+ + E+K
Sbjct: 32 CTFYEECGK---NPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAY---EAFYQRSFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKIAPCNESQG-DDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALI-IIFTAVFVLLSAVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSP--------HTILGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKN--FSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMADYGAPVFPFLAVGGY-QGTDYSEAEALIITFSLNNYPADDPRMAQAKL-WEEAFLKEMESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQR---EAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEK--------EGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLMCNIN---VGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSS--CCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSDG-------QVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEK 1279
BLAST of Niemann-Pick disease, type C1 vs. UniProt/SwissProt
Match: sp|Q9VRC9|NPC1B_DROME (NPC intracellular cholesterol transporter 1 homolog 1b OS=Drosophila melanogaster OX=7227 GN=Npc1b PE=2 SV=2) HSP 1 Score: 748.814 bits (1932), Expect = 0.000e+0 Identity = 464/1254 (37.00%), Postives = 692/1254 (55.18%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPS------LCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV--DTGYGGS--IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYL---NEVKGMNQTML---PCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPL-----SPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGF-----GDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNN-VVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRL-YPDGSFCPASVVNSTCNNCPANFTAKH-RPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSD-TRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHA 3777
CIWYGQ + + N T P +PLN+ T K CP K + S LCC+ Q+ T++ LS A +F CP C RN CA+TC N F+T DT G ++ + Y L ++ ++NSC + + A+D CG+ + K C+ +Y+ +GD + + PFQINY + +G N+ L P +D AC+C DC SCP P P + + I G+ G FI+ ++ +S +IF +G + P V + F + + F WG F A+ +IVL++ LS GI +TTDPVELW+ S R KDYFD++FGPFYRT Q+ + ++T FT ++ S L +GP F + L+ V L + I + + + L+ IC+ P+ +P ++CA+ SV YFQ+++ + + D N I Y++Q+ +C++ P E C G FGGP+ P +A GG G+ +Y +T LV+TF+ N D++ +++ + WEK F++ ++++ D I+Y AERS+QD I SE ++ T+ +SY++MF YV I LG + + +S++ L + ++IVL SV CS+GFW YL+V T++ +EV+PFLVLAVGVDN+FI+V TYQR D SK TT + I + +VGPS+L ++ SE F G +++MPAVK F++YAA A+L DFLLQIT +A++ +D KR R+D+LCCV+ + D V + K G+L +F FY+P L PV+ V++ F +L I L+Q++SMPK+S+++ YF + L++G PVY+++K G NY QN+ICG CN SL QL+ +Q P +T ++ +SWLDD+ W S CC+ G FC ++ + C C FT RPDA+ F+ Y+ +FL + P +C K G A+Y AV I DD V+ +YFM Y T T ++ L+ I+ + K N+ E+ Y VFY++YEQYLT++ LG+ L + LVT ++ GLD +T I+ F +I I+ +M G M+ W I +NA+S+VNLV+ +GI VEF+AHIVR++ +R++ T ERAR L GSSVLSGITLTK GI+VL FS SQ+FQ+FYFRMYLGIV+ GAAH
Sbjct: 24 CIWYGQSHMIGAHWV-NKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSYACACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIAC----ALSFFIF-----------WGAFGKTSAPSVCMPTLFGE-------FFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFT---HETSNGVLNFGPAFEYNFLKEVFELQDSIMKLG-----MADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTI-NYLNQLEDCLRVP-------MMEDCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDES--KLEPNMKWEKLFVDFLRDYKSDRLD--IAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDH---SKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLAIS---DCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAV-IYTIDDVGMSTVQ--DSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKE---NNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSF--KRAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHG 1220
BLAST of Niemann-Pick disease, type C1 vs. TrEMBL
Match: A0A1S3IJ92 (Niemann-Pick C1 protein isoform X1 OS=Lingula unguis OX=7574 GN=LOC106164556 PE=4 SV=1) HSP 1 Score: 1045.42 bits (2702), Expect = 0.000e+0 Identity = 590/1315 (44.87%), Postives = 818/1315 (62.21%), Query Frame = 1
Query: 106 DKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYG--GSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNAPFQINYLNE-----VKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIY--------------LKKNKY--DKDYGNGIVPATPEV--------DDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYD-ISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNL-PIATYMDQIMECIKDPTNIKPTKFKEI-CNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIK--KIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGS----FCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL--------------------------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK 3852
D C+WYG+ + KILN Y G KPL N + L +LCP N S CC+ DQ+ TL + S + G CP+C NF +LYC TC +F+ VD + VTY ++E F +FNSC +VV+ S N A+ +CG + C+ + +G+ N+PFQI+Y+ + N + PC +DD ACSCQDC +C P P+ P ILGID FI+ +F FF++ I IF Y L++N + + D + + P +I+ +K G ++ +L F +WG FVARR L+VL +G+++ + L G++ V DPV+LWS+P S AR KDYFD++FGPFYRTEQ+II PK+++ + N D S GPVF + L + L I+++ N LEDIC+KPLSPD C +MSV+ YFQNN+T+L+ D ++L + Y D ++ C + PTN T ++ C +FGGPV P++A GGF + NY D+TALV+TFIVNN + ++S Q A L WE+ +L+ ++ + + D ++Y+AERS+QDEI+R+S +D+ TI +SY+IMF Y+TI+LG+ N+ ++ +DSK+TLG VLIV +SV S+GF+SY+ VPMTLII+EV+PFLVLAVGVDN+FILVQ YQR + N + E+++ R+V KVGPSMLL+S SE+LAFF G + +MPAV+IFSLYAA AVLF+FLLQI+V +A+L LD KR E R+DV CCV++ + P K L F +YAP L VR V++ FVGW +L+ + + L+QKLSMP+DSY++ YFDA+A YLSVGPPVYF+VKDGY+Y + QN ICG GC++ SL+GQ+ +AS+ NV+ I+ +SWLDD+F W K G+PPCCR D CP+ V NS+C C + T H PD F YL +FL +NP ++C KGGHAAYGQAV+ + +IG +YFM+YHTILKT DY EAL+ + ++A ++T+ + + N +FEV PYSVFYVFYEQYL + K W L +C +L+VTFVLLG D + +++ I +I SMFG M+LWGI +NA+S+VNL+M +GISVEF +HIVRA+ V ++R+ERA++ L MGSSVLSGITLTKLGGIIVLAFSKSQLFQ+FYFRMYLG+V+FGA H +IFLPV LS+ GP +N+ + E+++
Sbjct: 24 DHCVWYGE-KTLDSGKILNPFYNGTAKPLLNESAKAILKELCPHMVT-GENISTCCSPDQIYTLQKNMGVPSQLIGRCPSCYSNFRKLYCDFTCSATHSSFLRVDQVIPVLNLVNQVTYFIDEGFADRMFNSCKDVVMPSNNEKAMSVLCGNAN--CNAKKWLNFMGNPI-NSPFQIHYIMSGLPPGYETFNISTTPC-YEAVDDDSLACSCQDCPKACGPEPTPKPPPPKCYILGIDCAFFIMGCIFIGFFLVFIIGNIFYYIICKNTLGVNRQDDLEENDWAINSDSSDTVPVLKPGAAQRRVIGKHEINCLEKIGFHLDRWLQKIFTKWGTFVARRPLVVLIIGLLLCVALGCGLLKLSVIVDPVQLWSAPKSVARTQKDYFDQHFGPFYRTEQLIITPKNQSKWWRTNLDPYSPGETLIGPVFKKEFLLEILDLQTKITSLVAHDPDTNVTISLEDICYKPLSPDNNHCTIMSVLNYFQNNVTRLEYTAWDGYHLQELGDYFDHLLSCARGPTNPTDTALTKLPCLAEFGGPVLPWVALGGF-EGDNYEDATALVVTFIVNNHV-KDSDQKNATL-WEQVYLDFMKEYVKKERDFTVAYSAERSIQDEINRESNSDVLTILISYLIMFAYITISLGEANSCDTVRLLIDSKITLGFAGVLIVFLSVISSLGFYSYIGVPMTLIIIEVIPFLVLAVGVDNIFILVQAYQRSQRRH---NESREEQLGRIVGKVGPSMLLTSSSETLAFFLGALIDMPAVRIFSLYAAQAVLFNFLLQISVFVALLSLDVKRQENNRIDVACCVKVGKSIPP---------KQDSYLLACFKNYYAPFLMSDWVRPSVIVIFVGWCCASLAMVPKLSTGLDQKLSMPRDSYVLTYFDAMAKYLSVGPPVYFVVKDGYDYSTLEGQNWICGLPGCHQDSLIGQISLASKFSNVSRIAQPASSWLDDYFAWLKPGGSPPCCRAIKDDHGKEVLCPSLVDNSSCYKCNTSITRDH-PDKDTFVRYLPWFLEDNPGIKCAKGGHAAYGQAVHFNDA-----AKTQIGGSYFMSYHTILKTSQDYIEALRYARQVANNITKAMNDAMTGTEEEVAYKYSAQGNTERNITLEKHKNKKKFEVYPYSVFYVFYEQYLLIVKDTWFNLTLCGVAILVVTFVLLGFDLYSAILVILTISMIEISMFGMMHLWGIDLNAVSLVNLIMCVGISVEFCSHIVRAFAVSIRNSRVERAKDALAHMGSSVLSGITLTKLGGIIVLAFSKSQLFQVFYFRMYLGMVLFGATHGLIFLPVLLSYIGPPINKAILFEKQQ 1311
BLAST of Niemann-Pick disease, type C1 vs. TrEMBL
Match: A0A1S3IIC0 (Niemann-Pick C1 protein isoform X2 OS=Lingula unguis OX=7574 GN=LOC106164556 PE=4 SV=1) HSP 1 Score: 1045.03 bits (2701), Expect = 0.000e+0 Identity = 591/1315 (44.94%), Postives = 816/1315 (62.05%), Query Frame = 1
Query: 106 DKCIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYG--GSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNAPFQINYLNE-----VKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIY--------------LKKNKY--DKDYGNGIVPATPEV--------DDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYD-ISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNL-PIATYMDQIMECIKDPTNIKPTKFKEI-CNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIK--KIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGS----FCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTL--------------------------GNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK 3852
D C+WYG+ + KILN Y G KPL N + L +LCP N S CC+ DQ+ TL + S + G CP+C NF +LYC TC +F+ VD + VTY ++E F +FNSC +VV+ S N A+ +CG + C+ + +G+ N+PFQI+Y+ + N + PC +DD ACSCQDC +C P P+ P ILGID FI+ +F FF++ I IF Y L++N + + D + + P +I+ +K G ++ +L F +WG FVARR L+VL +G+++ + L G++ V DPV+LWS+P S AR KDYFD++FGPFYRTEQ+II PK+++ + N D S GPVF + L + L I+++ N LEDIC+KPLSPD C +MSV+ YFQNN+T+L+ D ++L + Y D ++ C + PTN T ++ C +FGGPV P++A GGF + NY D+TALV+TFIVNN + ++S Q A L WE+ +L+ ++ + + D ++Y+AERS+QDEI+R+S +D+ TI +SY+IMF Y+TI+LG+ N+ ++ +DSK+TLG VLIV +SV S+GF+SY+ VPMTLII+EV+PFLVLAVGVDN+FILVQ YQR + N + E+++ R+V KVGPSMLL+S SE+LAFF G + +MPAV+IFSLYAA AVLF+FLLQI+V +A+L LD KR E R+DV CCV++ + P K L F +YAP L VR V++ FVGW +L+ + + L+QKLSMP+DSY++ YFDA+A YLSVGPPVYF+VKDGY+Y + QN ICG GC++ SL+GQ+ +AS+ NV+ I+ +SWLDD+F W K G+PPCCR D CP+ V NS+C C + T H PD F YL +FL +NP ++C KGGHAAYGQAV+ + +IG +YFM+YHTILKT DY EAL+ + ++A ++T+ + + N +FEV PYSVFYVFYEQYL + K W L +C +L+VTFVLLG D + +++ I +I SMFG M+LWGI +NA+S+VNL+M +GISVEF +HIVRA+ V ++R+ERA++ L MGSSVLSGITLTKLGGIIVLAFSKSQLFQ+FYFRMYLG+V+FGA H +IFLPV LS+ GP LN+ + +K
Sbjct: 24 DHCVWYGE-KTLDSGKILNPFYNGTAKPLLNESAKAILKELCPHMVT-GENISTCCSPDQIYTLQKNMGVPSQLIGRCPSCYSNFRKLYCDFTCSATHSSFLRVDQVIPVLNLVNQVTYFIDEGFADRMFNSCKDVVMPSNNEKAMSVLCGNAN--CNAKKWLNFMGNPI-NSPFQIHYIMSGLPPGYETFNISTTPC-YEAVDDDSLACSCQDCPKACGPEPTPKPPPPKCYILGIDCAFFIMGCIFIGFFLVFIIGNIFYYIICKNTLGVNRQDDLEENDWAINSDSSDTVPVLKPGAAQRRVIGKHEINCLEKIGFHLDRWLQKIFTKWGTFVARRPLVVLIIGLLLCVALGCGLLKLSVIVDPVQLWSAPKSVARTQKDYFDQHFGPFYRTEQLIITPKNQSKWWRTNLDPYSPGETLIGPVFKKEFLLEILDLQTKITSLVAHDPDTNVTISLEDICYKPLSPDNNHCTIMSVLNYFQNNVTRLEYTAWDGYHLQELGDYFDHLLSCARGPTNPTDTALTKLPCLAEFGGPVLPWVALGGF-EGDNYEDATALVVTFIVNNHV-KDSDQKNATL-WEQVYLDFMKEYVKKERDFTVAYSAERSIQDEINRESNSDVLTILISYLIMFAYITISLGEANSCDTVRLLIDSKITLGFAGVLIVFLSVISSLGFYSYIGVPMTLIIIEVIPFLVLAVGVDNIFILVQAYQRSQRRH---NESREEQLGRIVGKVGPSMLLTSSSETLAFFLGALIDMPAVRIFSLYAAQAVLFNFLLQISVFVALLSLDVKRQENNRIDVACCVKVGKSIPP---------KQDSYLLACFKNYYAPFLMSDWVRPSVIVIFVGWCCASLAMVPKLSTGLDQKLSMPRDSYVLTYFDAMAKYLSVGPPVYFVVKDGYDYSTLEGQNWICGLPGCHQDSLIGQISLASKFSNVSRIAQPASSWLDDYFAWLKPGGSPPCCRAIKDDHGKEVLCPSLVDNSSCYKCNTSITRDH-PDKDTFVRYLPWFLEDNPGIKCAKGGHAAYGQAVHFNDA-----AKTQIGGSYFMSYHTILKTSQDYIEALRYARQVANNITKAMNDAMTGTEEEVAYKYSAQGNTERNITLEKHKNKKKFEVYPYSVFYVFYEQYLLIVKDTWFNLTLCGVAILVVTFVLLGFDLYSAILVILTISMIEISMFGMMHLWGIDLNAVSLVNLIMCVGISVEFCSHIVRAFAVSIRNSRVERAKDALAHMGSSVLSGITLTKLGGIIVLAFSKSQLFQVFYFRMYLGMVLFGATHGLIFLPVLLSYIGPPLNKATLYASQK 1311
BLAST of Niemann-Pick disease, type C1 vs. TrEMBL
Match: A0A267FSF3 (SSD domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig027873g1 PE=4 SV=1) HSP 1 Score: 1030.39 bits (2663), Expect = 0.000e+0 Identity = 577/1315 (43.88%), Postives = 821/1315 (62.43%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQ-YAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV----DTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTH-EKCDPVAFYKALGDATSN--APFQINYL----------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIV--ISIYIFIYLKKNKYDKDYGN---------------GIVPATPEVD-DISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEI-CNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNT-DLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNN--------VVTP---VDAVP--VAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGS--FCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK--LLEKMPENNSWGN 3891
CI Y QC K K NC Y GPPK LN++ +L +CP + CC Q+ TL QL PA ++F CP C +NF L+C TC PNQ +++ T +G I + YN+ F GLFNSC +V+ NS AI +CG+ EKC Y +GD +N APF YL + MN +++ C + CSC DC+A+C PPP P K + ILG+DGW I+ +V+ F ++ +I+ +Y + K + N P D DI D+ A+ E+ L F WG VA R +IVL G+++ + LS G+ +VTTDPVELWS+P S+AR+ K++FDENFGPFYR+EQII++P+++T F+ Y + PV L+++ L H++NMEV+S L L DICFKPL+PDY CAV S + YFQ+N T L+ ++F+L A ++ ++ C ++P ++ ++ C ++GGP++P++ FGGF + Y +S+A+V+TFIVNN ++ SKQ++AA +WE AFL V + F E N+ + + Y++ERS++DE++R+S +D+ TI +SY++MF YVTITLGQY + ++ +D+KVTLGL V+IVLI+V CS+GFWSYL P TLII+EVVPFLVLAVGVDN+FILVQ YQR D Y+ + +IAR V VGPSMLLSSLSES+AFF G +T MPAV++F+LYA AVL DFLLQI+ +A+L LDA+R A R DVLCC+ + P +D+ P SG+L ++F ++ + +LF++ VR V++ F GW L+ +H + V L+Q+LSMP+DSY+I+YFD + YLSVGPPVYF+V+ +Y + QN++C +GC +KS++GQL S+ P +YI + +SW DD+ W SG+PPCCR + GS FCPA+ + C +C NFT+ RP F YL +FL +NP C KGGHAAY A+ +S+ + A+Y+MTYH++L+T D+ A K +I++ + + + S + V PYSVFYVFYEQYLT+ + L +C+ + +VTF+LLG D +T I+ I LI+NSM GFMY W I +NA+S+VNLVM +GISVEF +H+VRA+ V + +R+ RAR+ V MGSSV SGITLTKLGGI++L F+KSQLF+IFYFRMYLGIV+FGA H ++FLPV LS+ GPA + ++ ++++ LLE+ E++S G
Sbjct: 22 CIMYDQCGKGPTGKSTNCVYNGPPKLLNDSAAVASLKSICPDLFDPGSDTIYTCCAPSQVQTLSQQLDPAGLLFKRCPGCWKNFRELFCQFTCSPNQTHYMRPTQVNQTSHG--ILNIDYNITSTFSYGLFNSCKDVM--QGNSKAIGGLCGSVSVEKCTIQDIYSFIGDTKANSLAPFNTKYLIQDQCYTNGSESMCPMNSSLVKCELGDKAGGIAPCSCTDCQAACVKPPPIPAPPKPWRILGVDGWYLILFLVYAVFILLFGGANIFFHVYANNSMGFKLFQNEPPSASTAASNATAASSSEGRPLSDKDIGCGDRINAEFESRLEAAFTSWGRLVADRPVIVLVAGLLLCVGLSCGVFFFQVTTDPVELWSAPDSTARQQKNFFDENFGPFYRSEQIIVIPRNQTLFSHDPYFEPLPYKVFSPVVRKQFLQKLLDLQTHVTNMEVWSDTLGRNMSLTDICFKPLAPDYSTCAVQSPLGYFQSNGTNLNLTHLNDFDLVDADWITHLVACTQNPISMNDNSPNQMSCFAEWGGPIYPWVVFGGF-NGTAYLNSSAIVLTFIVNNDVNSESKQVRAAKEWESAFLKVARQFKEDNSAEFDVRYSSERSIEDELERESNSDVLTILISYLVMFAYVTITLGQYKSCNRLFIDAKVTLGLAGVVIVLIAVACSLGFWSYLGFPATLIIIEVVPFLVLAVGVDNIFILVQHYQR-DAAYAD---CVQARIARSVGSVGPSMLLSSLSESVAFFFGALTSMPAVRVFALYAGMAVLVDFLLQISCFVALLSLDARRQAAGRPDVLCCLLASKDEQAAQQQQQLPREILDSNPDSAQSNNNSGLLFQLFKRYISAVLFQSWVRPFVILLFTGWACLCLASVHNVRVGLDQELSMPEDSYVIDYFDGIKRYLSVGPPVYFVVRGPLDYSDPSQQNLVCSRAGCPQKSMVGQLSQMSEIPTYSYIVSPPSSWFDDYVDWLDPSGHPPCCRYHTAGSGGFCPATSSATDCVSCNVNFTSDGRPVQSEFYRYLDYFLMDNPGPACAKGGHAAYATAIA------RSNATGAVTASYYMTYHSVLRTGDDFINAYKMAIKMTDDINTYFEN-VTQSKEINVFPYSVFYVFYEQYLTIVHDTVVNLSICVAAIGVVTFILLGFDLFSTCIILLTIGLILNSMLGFMYFWDITLNAVSLVNLVMTVGISVEFCSHLVRAFAVSKETSRLARARDSFVHMGSSVFSGITLTKLGGIVILGFAKSQLFKIFYFRMYLGIVLFGALHGLVFLPVLLSYVGPAGSVGRLRKRRRYGLLEEA-EDSSGGE 1319
BLAST of Niemann-Pick disease, type C1 vs. TrEMBL
Match: A0A210Q408 (Niemann-Pick C1 protein OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT23882 PE=4 SV=1) HSP 1 Score: 1014.99 bits (2623), Expect = 0.000e+0 Identity = 588/1318 (44.61%), Postives = 820/1318 (62.22%), Query Frame = 1
Query: 112 CIWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVD--TGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATS-NAPFQIN-YLNEVKG-----------MNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIV-ISIYIFIYLKKNKY-------------DKDYG-NG-------IVPATP----EVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIV-PKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTD---EFNLPIATYMDQIMECIKDP-TNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNN-------IKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVN--STCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQ---KKLLEKMPENNSWG 3888
CIWY +C K+ + NC Y GP K L ++ + + CP K CC+ Q+ T++ + + CP C NF+ +YC LTC P Q + ++V T +++V Y ++++F G++NSC NV + SAN A++ CG T +KC P + + +G+ ++ + PF+I+ Y+ +V MN T+ PCN + ACSCQDC ASC PP P+ TILGID W FI + FF++ IS+ + +N + D Y NG + A P + DIS ++ G KVE++L F RWG F AR IVL++G+I+ L +GI KVTT+PVELWSSPSS+ R KDYFD +FGPFYRTEQ+II P ++T + S ++ Y +F+ + L + L I N+ + N +LEDICF+PLSPD + C + S ++Y+Q + ++D +V + +FN+ A Y+D CI P T T + C G PVFP++ GGF D K+Y +TA VITF+VNN LD+ A WEK F++ ++N+S N + I+Y++ERS++DEI+R+S +D+ TI +SY+IMF Y+++TLGQ N+ I ++ VDSK+ LGL V IVL+SV S+GF+S+L +P TLII EVVPFL LAVGVDN+FILVQ+YQR D S++L E +I R+V +VGPSMLLSSL+E++AFF G +T+MPAVK+FSLYA AV DFLLQIT + ++ LDA+R E+ R D+ CCV+++ + K G L + +Y+ L K VR +VVI F GW + + IH + V L+QKLSMP DSY+++YF L+ YL VGPPVYF+V++G++Y + QN ICG +GC + SL GQ++ AS PN + ++ +SWLDD+F W G+P CCR + +GSFCP++V + S C C + P + F +L +FL++NP C KGGHAAYG AV D H +GATYFMTYHTILK +DY EALK++ IA ++T + N Q++V PYS+FYVFYEQYLT++K L +C+ + +V FVLLG D+ + L++ I +I+ MFGFMYLW I +NALS+VNLVMAIGISVEF AHI RA+ V TR+ERAR+ L MGSSVLSGITLTKLGGIIV+AFSKSQLFQ+FYFRMY+G+VIFGA+H +IFLPV LS+ GP LN+ K+ +Q K L+ + EN++ G
Sbjct: 28 CIWYDEC-KTTSTGVQNCAYNGPAKLLTDSAALKRIQHYCPGLYKGPNATETCCSPSQMYTIETNMGLPEQLLRRCPACYYNFLEIYCYLTCSPEQSDSISVKKYTDNNTVVESVNYVMSKDFAFGMYNSCKNVEMPSANELALNMFCGRTADKCTPYNWLQYMGETSNGHTPFEIDFYIQDVPWVSPSTNKSTVPMNSTITPCNKK--YQNQSACSCQDCEASCAPIPPIPAPAVEPTILGIDAWYFITGCCYLVFFIVFGISVMWHNIMTRNAFGIYTAEEQVKSVEDDHYQINGRRKKKKMMKKADPVPLIQQGDISCLERLGEKVESFLQRSFQRWGTFCARHPFIVLAIGVILGGGLCVGIPFLKVTTNPVELWSSPSSTVRTQKDYFDSHFGPFYRTEQLIITRPHNKTYVSHKLPPPSVQSTNYSNLFDKEFLHMLLDLQLQIQNINATYE--NRTIRLEDICFQPLSPDNKGCTIQSPLEYWQESHEKIDAVVWETIYKFNIK-ANYLDHAEYCISAPATTWDTTGLNQSCLSVSGQPVFPWIVMGGF-DGKDYQSATAFVITFVVNNHLDEALNGPAEA--WEKEFISFMKNYSSPN--MTIAYSSERSIEDEINRESNSDILTILISYLIMFLYISLTLGQLNHCYCLGERIDRLLVDSKILLGLAGVTIVLLSVGASIGFFSFLGIPATLIIAEVVPFLALAVGVDNIFILVQSYQR-DVRPPSESL--EDQIGRIVGRVGPSMLLSSLTETVAFFLGALTDMPAVKVFSLYAGMAVFIDFLLQITCFVGLMTLDARRQESHRYDMCCCVQLHEEKSE---------KSEGWLFRVVKDYYSHFLLKEWVRPIVVIVFTGWLSISFALIHKVDVGLDQKLSMPDDSYVLDYFTNLSEYLHVGPPVYFVVEEGHDYITMQGQNDICGGNGCPQDSLAGQVYTASLRPNYSRVAQPVSSWLDDYFSWLNSGGHPQCCRSFINNGSFCPSTVPDNVSLCEPCQLHGAINGHPVKEDFMKFLPWFLSDNPGTICAKGGHAAYGSAV------DLLHNKTGVGATYFMTYHTILKNSTDYIEALKHANSIAENITSLIGQ---NGKQYKVFPYSIFYVFYEQYLTMWKTTITNLSLCVIAIFIVAFVLLGFDFFSALMIVITITMIIIDMFGFMYLWDISLNALSLVNLVMAIGISVEFCAHITRAFAVSLLPTRVERARDALANMGSSVLSGITLTKLGGIIVMAFSKSQLFQVFYFRMYMGMVIFGASHGLIFLPVLLSYIGPPLNKAKLYKQQHAKNTLDHIQENDTAG 1313
BLAST of Niemann-Pick disease, type C1 vs. TrEMBL
Match: K1PF48 (Niemann-Pick C1 protein OS=Crassostrea gigas OX=29159 GN=CGI_10006575 PE=4 SV=1) HSP 1 Score: 1010.75 bits (2612), Expect = 0.000e+0 Identity = 571/1298 (43.99%), Postives = 822/1298 (63.33%), Query Frame = 1
Query: 121 YGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGG---------SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNA--PFQINY------LNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVIS-IYIFIYLKKNK---------YDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKD-----RTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFN--LPIATYMDQIMECIKDPTNIKPTKFKEI-CNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI-----VEQKKLLEKMPENNSWGN 3891
YG+C + P LNC Y GPPKP+N + G + L CP D+ P CC+ QL + + + CP+C NF+ L+C TCDP Q +F+ V + +V Y+++E + G++NSC +V + S N+ A+D +CG C + +G +TSN PF INY ++ MN ++ PC+ G + ACSCQDC+A+C PPP P + T+LG+D W F + I F AF ++ +S I + ++ +N+ DK Y + + + + G +E L + F RWG F A+ + ++ G+++ V S+GI++ +VTT PV+LWS+ +S AR+ K+YFD +FGPFYRT+Q+II + R INY I RN Y +F+ L +V L I N+E K + LEDICF+PL+PD C + S+++Y+QNN T+LD+I D+++ Y+D +C + P ++ ++ C G G P+FP+++ GGF +K Y +STALVITF+VNN +D+ KQ + A WE FL ++NFS+ D+ I+Y+AERS++DEI R+S +D++TI +SYI+MF Y++ITLGQ+ + V SK +LGLC V IVL+SV+ S+G +SY + TLII+EVVPFLVLAVGVDN+FILVQ +QR DE + + L E +I R++ KVGPSMLL+S SESLAFF G +T+MPAV++FSLY+A AVL DFL Q+TV +AV+ LDAKR E+ R+D+ CCV++ GIL +IF FY+ L VR +V++ FVG+ F+ SQIH I + L+QKLSMP DSY++NYF L+ YL VG PVYF+V+DG +Y ++ Q+++CG +GC E S++GQ+ A++ N TYI+ ++W+DD+F W + G+PPCCR+Y G+FC A+VVN++C CP + TA RP ++ F +L ++L +NP ++C KGGHAAYG AVN+KN + +GATYFMTYH+I+K DY LK + ++AA++T L+ G N +V PYSVFYVFYEQYLT+ + L +C+ + +VTFVLLG D + ++ I +I+ + G M LW I INA+++VNLVMA+GISVEF AHI RA+ V TR++RA++ + MGSSVLSGITLTKLGGIIVLAF+KSQLFQ+FYFRMYL IV++GA H +IFLPV LS+ GP +N+ K+ E+ + E+ P +N N
Sbjct: 2 YGEC-QEGPTGNLNCVYDGPPKPMNESEGLEILRTYCPNIVTSDQ-PLTCCDLAQLRSFKKNMGVPQQLLLRCPSCYYNFLYLFCYFTCDPMQADFLKVSMKMPNIANPSDPREVVYSVDYHVSETYAYGMYNSCKDVQMPSTNAKALDIICGKPAADCSAQDWLNYMG-STSNGQTPFAINYHIDNTSTVDIHPMNHSVTPCDQKYG--NLSACSCQDCQATCAPLPPPPSPREPCTVLGMDCWFFAMLITFIAFCVVFLSFIIVSMFFNRNRPAKTENKWSQDKKYKDS--SSLEGKHRGTVLQRGGLWIETSLEMVFRRWGTFCAKNPVKIIVAGLVLGAVFSVGIVMFEVTTSPVKLWSAENSRARQEKNYFDSHFGPFYRTQQLIITRPENASGVRHEVPGINYGI-YRN--YTSIFDKSFLHKVLDLQLTIQNLEADHK--GSKVALEDICFQPLAPDNTDCTIQSILEYWQNNHTRLDKIKYDDYSGFYVEGDYLDHFSDCARAPASVSDQHHMDLSCLGASGQPIFPWISLGGFTGEK-YNESTALVITFVVNNHVDE--KQNEKARAWELEFLRFMKNFSDP--DMIIAYSAERSIEDEIQRESASDVWTIVISYIVMFGYISITLGQFGRCSRCVVSSKTSLGLCGVCIVLLSVSSSLGLFSYCGIAATLIIIEVVPFLVLAVGVDNIFILVQAFQR-DEGHPDEEL--EDRIGRLLGKVGPSMLLASCSESLAFFLGALTDMPAVRVFSLYSAMAVLLDFLFQVTVFVAVMTLDAKREESNRLDICCCVKLEK--------SKKNEASEGILFKIFKNFYSEALLSKFVRPVVMVLFVGYLCFSASQIHKIEIGLDQKLSMPDDSYVLNYFGNLSEYLHVGAPVYFVVEDGLDYTTKVGQDVVCGGTGCPEDSVVGQISTAAKQANYTYIAHPTSAWIDDYFDWLRPGGDPPCCRVYNQAGNFCTATVVNASCATCPVHKTADSRPVSQDFMKFLPWYLKDNPGIKCAKGGHAAYGSAVNLKNNNKA------VGATYFMTYHSIMKDNKDYITGLKEARKVAANMTNMLRLKTGG-NSTKVFPYSVFYVFYEQYLTIVEDTIKNLSICIAAIFVVTFVLLGFDIISAFLVVLTITMIVIDILGLMALWDISINAVTLVNLVMAVGISVEFCAHITRAFAVSHQTTRVKRAKDAVAHMGSSVLSGITLTKLGGIIVLAFAKSQLFQVFYFRMYLAIVVYGATHGLIFLPVLLSYIGPPVNKVKLDFIESSEEGNVHEQRPHSNGHTN 1264
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Cavefish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161]) HSP 1 Score: 865.914 bits (2236), Expect = 0.000e+0 Identity = 516/1253 (41.18%), Postives = 752/1253 (60.02%), Query Frame = 1
Query: 145 PNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGG-----SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATS-NAPFQINYLNEVKGMNQTMLPCNMNG---GEDDGEA-CSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAF-FMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFT-WINYDI-SARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNCPA-NFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVV-PYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK 3852
P K NCNYTGPP PL G L +LCP A N S+CC+T QL TL + CP C NF+ L+C LTC P+Q F+ T + ++ ++Y +N+ F ++N+C +V S+N A+ +CGT + C P + + + + PF IN + T++ + G DDG CSCQDC +C P P +TILG+D I+ + + +F F+ ++++ +K +YG + + + + G + E L + F WG F R L+V+ ++ S G+ +VTTDPVELWS+P S AR+ KDYFD++FGPF+RTEQ+II TP+T W ++ S N+ + P+FNI LL ++ L I N+ + L+DIC PL+P C ++SV+ YFQN+ L+ +D F + Y M C +P + + F + C G FGGPVFP+L GG+ + Y ++TALV+T V N L+ K+ KA L WEK F++ ++N+S N +L I++++ERS++DEIDR+S +D+ TI +SY+IMF YV++ LG ++ + + VDSK++LG+ +LIVL SV S+G +SY VP+TLI++EV+PFLVLAVGVDN+FI+VQT+QR DE + L Q+I R++ V PSMLLSS SE+LAFF G ++ MPAVK FS +A A++ DF+LQI+ +++L LD KR E R+D+LCCV++ V + K GIL F K YAP + VR LVV FVG F+++ I + + L+Q+LSMP DSY+++YF L GCN SL+ Q++ AS + + IST+ +SWLDD+F W K + CCR Y + G+FC ASVV+ +C +C A + K RP+ F +L FL++NP+++C KGGHAAY AV +K+ D +GATYFM+YHTIL S +++K + E+A +++ ++G++N+ ++V PYSVFYVFYEQYLT+ + LGV L +L V+ VLLG + + +++ I +I+ +MFG M+LWGI +NA+S+VNLVM+ GISVEF +HIVRA+ V TR+ERA+E L MGSSV SGITLTK GGI++LA SKSQ+FQ+FYFRMYL IV+ GA H +IFLPV LS+ GP++N+ K + ++
Sbjct: 4 PEKKYNCNYTGPPIPLPE-DGQVLLKELCPGLAY--GNQSVCCDTKQLSTLKGNVQLPLQFLSRCPACFYNFMTLFCELTCSPHQSLFLNA-TSFSQDHNMTNVVELSYYINQTFADAMYNACKDVQAPSSNMPALSLLCGTDPKDCTPTKWISYMFNINNKQVPFAINPIFAGPPAGMTLMNNDTFGCTESLDDGSGPCSCQDCSKACGPKPIPPPVRPPWTILGLDAMTVIMWVSYVSFLFVFIVALLGAWCYRKRTITSEYG------PIQGNQATCCESVGERFENSLRVCFSLWGSFCVRHPLLVILFSLVFVGGCSSGLARMRVTTDPVELWSAPHSQARQEKDYFDQHFGPFFRTEQLIIT----TPWTDWFIFETTSGPNIPFAPIFNISLLHQILDLQTDIENL--VADYNGENVTLQDICISPLAPYNNNCTILSVLNYFQNDPDVLNHTNSDPFYIYF-DYHTHFMYCASNPVALDDMSTFHDPCMGTFGGPVFPWLVLGGY---EAYNNATALVLTLPVANYLNNTEKRGKA-LAWEKEFISFMKNYS--NPNLTIAFSSERSIEDEIDRESNSDISTILVSYVIMFIYVSLALGHIHSFQTLLVDSKISLGIAGILIVLSSVISSLGIFSYAGVPLTLIVIEVIPFLVLAVGVDNIFIIVQTFQR-DERLQHEEL--HQQIGRILGDVAPSMLLSSFSEALAFFLGSLSHMPAVKTFSFFAGLAIIIDFILQISCFVSLLGLDIKRQERNRLDILCCVKLPE---------VQQEKTEGILFRFFKKIYAPFILNEWVRPLVVAVFVGMVSFSIAVIDKVEIGLDQRLSMPDDSYVLDYFGNLM--------------------------------GCNNDSLVQQIYTASLMSDYSKISTTPSSWLDDYFDWVKPQSS--CCRYYNNTGAFCNASVVDPSCVHCRAMTPSGKQRPNGTDFMKFLPMFLSDNPNIKCGKGGHAAYSTAVVLKDND------TNVGATYFMSYHTILTNSSVSIDSMKMARELAHNIS----VSMGSTNKTDIVFPYSVFYVFYEQYLTIVHDTALNLGVSLVAILTVSTVLLGFELWSAMLVTLTIAMILINMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHIVRAFSVSTKGTRVERAQEALAHMGSSVFSGITLTKFGGILILALSKSQIFQVFYFRMYLAIVLLGATHGLIFLPVLLSYIGPSVNKAKAMAARR 1177
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Cavefish
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:NCBI gene;Acc:103040688]) HSP 1 Score: 760.37 bits (1962), Expect = 0.000e+0 Identity = 489/1309 (37.36%), Postives = 726/1309 (55.46%), Query Frame = 1
Query: 112 CIWYGQCDKSNP-------NKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFV----TVDTGYGGS----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINY--------LNEVKGM---NQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMI--VISIYIFIYLKKNKYDKDYGNGIVPATPEV----DDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSP---DYEKCAVMSVMQYFQNNITQLDRI-------VTDEFNLPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNF-SETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDG----SFCPASVVNSTC-NNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVE-QKKLLEKMPENN 3879
C Y +C +NP N + C G + + ++ L ++CP + + CC+ QL++L L+ + + CP+C NF ++C TC PNQ + T+ G+ + A ++ +F F SC NV + + +AI T+CG K C + GD+++ AP I++ + GM +L CN G+ CSCQDC SCP PPP P F I +DG + I I+F ++ V I I KK+K KD V T + +I+ DK + +L F WG +AR L V+ + + S G++ ++TTDPV+LWS+P+S ARR KD+ D NF PF+RT Q+I+ R + + + N + + + DL+ ++ L I +E +S+ LN L+D+C+ PL+P CAV S+ QYFQN++ L+ VT E + + D + C+ P + + T C D+GGPVFP+LA GG+ D+ ++T++ A ++TF +NN + K K WE FL +V+++ ++ NT+ +Y AERS++DEI+R + D +SY ++F Y+ I LG+Y + K+I VDSK+ +GL +LIV SV S+GF+ ++ +P +LII++VVPFLVLAVG DN+FI V YQR DE S + T E++I RV+ V PSMLL SLSES+ FF G ++ MPAVK F+LYAA +VL DFLLQ+T +A+L LDA+R +A R DV CCVR+ N P G L + K+YAP L R +V++ F+ ++ + + V L+Q+LSMP DSYM+ YF+ L Y VG P YF+ G+N+ S N +C + GC++ SL ++ A++ P +Y++ +SW+DDF W CCR+Y G FCPAS C C P RP+ F+ +L FL N P +QCPKGG AY AV N EI A+ FM YHT LK +YT ALK + E+A ++T ++ G FEV PY+V YVFYEQYL++ + + + +CL +V +LLG+D + L+ I++I G M LWGI NA+S++NLV A+GISVEF++H+ R++ + TR+ERA++ +MGS+V +G+ +T L GIIVLAF+K+QL QIF+FR+ L I + G AH +IFLPVFLS+ GP LN+ ++E QKK ++M N
Sbjct: 33 CSMYDECG-TNPTVSGSLLNSSVPCKNYGAARQVV-GEHYKLLKQVCPMLDRGEGQTFACCSVQQLMSLQSSLTLSKAVLLRCPSCAYNFAHVHCVTTCSPNQSQTINITRTIPVNISGTEKEAVVAYQTYISTDFSDASFRSCKNVRIPATGGFAIATMCGRYGAKLCTAQRWLDFQGDSSNGLAPLDIDFRLIPPEQSADVPAGMVAYAGMVLGCN-ETTPTGGKECSCQDCEDSCPPVPPPGPPPGPFMIRDVDGVLVICSILFFFILLMFLVYLIAICCDGKKSKRRKDKNANEVDHTLNLTVHPSEITCTDKASLATQEFLGSMFQSWGTVMARHPLKVIFASVFVVAAFSTGMMNMELTTDPVQLWSAPNSRARREKDFHDANFAPFFRTNQLILTAPGRPSYIYDSILFGRTN--FSGLISKDLILQLLELQQKIQAIEFWSEELNKTASLKDVCYAPLNPTNPSLTDCAVNSLPQYFQNSVENLNAKANMTELGVTKEVD-----WRDHFIYCVNSPLSFQDITALDMSCMSDYGGPVFPFLAVGGYEDE-DFTNAEAFILTFSLNNYARDDPK-FKVVEKWESMFLEIVKDYQNDPNTNFTFAYMAERSLEDEINRTTVEDFPIFMISYGVIFLYIAIALGEYTSFKRILVDSKIVVGLGGILIVGCSVLTSMGFYGWVGIPSSLIIVQVVPFLVLAVGADNIFIFVLEYQR-DERRSGE--TREEQIGRVLGSVAPSMLLCSLSESVCFFLGALSTMPAVKTFALYAALSVLIDFLLQMTAFVALLSLDARRQDANRYDVACCVRVKN--------PPPSKPNQGFLFPLMKKYYAPALLCGFSRIVVMVVFLFMFCASIFLMCHVKVGLDQELSMPTDSYMLRYFEYLNKYFEVGVPTYFVTTKGFNFSSLAGMNAVCSSVGCDQFSLTQKIQYATEYPERSYMAIPASSWVDDFIDWLNPGSR--CCRIYTSGPNTGKFCPASESAFLCLRRCMPLTEDGVVRPNETEFNTFLPSFLGNRPDLQCPKGGLGAYDTAVVADNVTG------EIVASRFMAYHTPLKNSQEYTTALKIARELAHNITMAMRDMNGTDPDFEVFPYTVTYVFYEQYLSIVYEGLVNIALCLLPTFIVCCILLGMDLLSGLLNLLTIVMITVDTVGVMTLWGIDYNAVSLINLVTAVGISVEFVSHMTRSFALSTLPTRVERAKDATAKMGSAVFAGVAMTNLPGIIVLAFAKAQLIQIFFFRLNLVITLLGMAHGLIFLPVFLSYFGPPLNKAVLLEAQKKKAQEMESRN 1310
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Cavefish
Match: ENSAMXT00000012643.2 (patched domain-containing protein 3 [Source:NCBI gene;Acc:103027938]) HSP 1 Score: 162.54 bits (410), Expect = 2.981e-40 Identity = 179/707 (25.32%), Postives = 320/707 (45.26%), Query Frame = 1
Query: 1741 DWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKY-----------------SGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYL-SVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSF 3807
W F+ ++ N + + T +SY S Q E ++ +++ A++Y I + ++ +++N++ +KV L V+ ++V S G LNVP + + PFL+L +G+D++FI++ +Q+ + + S E ++A + S+ +++L++ LAF+ + +V+ F LYA TA+LF +L IT A L L+ KR R L C+++ P D P A Y ++ F K+Y P L + V++ ++G+ ++ I ++ K SY++ Y++A Y + GP V V + Y E ++++ C E+ F A +T+IS SWL F ++KQ N T + F ++L FL +P+++ V++ N+ I A+ F LKT +E + + + L+ T + +V Y +++Y+QY TV IQ VV+L ++L + L + F I ++ + GFM L GI ++++SM+NLV++IG SV+F AHI +V + E+ + L +G +L G L+ + G++VL+ S S +F+ F+ M+L ++ FG H I F+PVFLSF
Sbjct: 225 SWLNKFVELMTNVTTSIT--QVSYFTSISRQQEFEKSTKSVTHLFAITYFIAILFSVLSCVRFDNVR-----NKVWLACLGVISAGLAVLSSFGLLLLLNVPFAITVASS-PFLILGIGIDDMFIMISCWQQTNVHDS-----VEDRLAATYKEAAISITITTLTDVLAFYLSFSSPFGSVQSFCLYAGTAILFCYLYNITFFGACLALNGKREGGNR-HWLTCMKV-----PEDCPPEASRGYIACCVGGSYDHKTGAEEEHLMQGFFRKYYGPFLTTVWAKAAVIVLYIGYISVSVYGCTTIKEGIDLKNLAIDQSYLVQYYEAEKEYFHNYGPIVMLAVNGSFPYWDEAKRDLL---ESCIEE------FKA-----LTFISDLSVSWLHSFERYAKQEN---------------------------LNITTEAE-----FKNHLQTFLQRHPTLRLD----------VSLANES--------IQASRFF-----LKTSKPPSEKI---------MLQSLRETAQSCEVQPLVVYHPAFIYYDQY-TVIASNTIQTVSVATVVMLAISLILIPNPVCALWVAFAIASVIVGVAGFMALLGINLDSISMINLVISIGFSVDFSAHISYTFVSSTKASVDEKVVDALSNLGYPILQG-ALSTILGVVVLSVSVSYIFRTFFTIMFL-VISFGLLHGIAFIPVFLSF 831
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Cavefish
Match: ENSAMXT00000001333.2 (patched domain-containing protein 3-like [Source:NCBI gene;Acc:103042169]) HSP 1 Score: 146.362 bits (368), Expect = 4.773e-35 Identity = 180/741 (24.29%), Postives = 324/741 (43.72%), Query Frame = 1
Query: 1744 WEKAFLNVV-QNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLC------CVRMNNVVTPVDAVPVAKVKYSGI-----LHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGSFCPASVVNSTCNNCP-------ANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVF---YVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSF---CGPALNRKKIVEQKKLLEKMPENNSWGN 3891
W FL V N S + S + R V+ E + + LF+I +Y+I + ++ +++ ++ +KV + VL ++V S G ++ VP + + PFL+L +GVD++FIL+ +Q+ ++ + E ++A + S+ +++L++ LAF+ G+MT +V+ F LY +T++LF ++ IT A L+L+ +R + + C C + + V A ++G ++ F K+Y P L K+ + V++ YM+ YL+V F +K+G + ++ + + +EK+ + + PN+ I S S+ D+ S C + + SF + S + N +A+H VF D L FL ++ + Q VN N I A+ F + T D L L ++ Q VP V+ +++++QY + IQ V+L+ +LL + +L + F I ++ + GFM LW + ++ +SM+ LV+ IG SV+F AHI ++V + + E+A + L +G +L G T L G++VL+ SK+ +F+ F+ M+L ++ FG H I F+PVFL+F C + K+ + K+ LE NS GN
Sbjct: 218 WLNEFLKVFPSNLSTKFIKVTYSTSLSRQVEFEANTKDVIPLFSI--TYVIAIAFSILSCLRFDCVR-----NKVWVATFGVLSAGLAVLSSFGMMLHIGVPFVMTVANS-PFLILGIGVDDMFILISCWQQ-----TNVHDQVEDRLANTYKEAAISITITTLTDVLAFYIGLMTPFRSVQSFCLYTSTSILFCYIYSITFFGAFLVLNGRRENRNQHWLTCKEVPEECPTDQSKWHELCCVGGAYDLHTGSEEVQPMNHFFKKYYGPFLTKSWTKVFVILL-----------------------------YML--------YLTVSIYGCFQIKEGIDLRNLAADDSYVVRYYDDEKA-----YFSEYGPNIMVIVRSEFSYWDE----KNMSDLESCVEDFKNLSFIEKDIFTSWIKSYKYYGYHKNLNLSAEH-----VFKDNLGTFLR----------FYSDFRQDVNFTNN--------SIYASRFFIQTVNISTALDEMNMLNK---------------LRDTAQRCPVPLLVYHPAFIYHDQYAVIVSNT-IQNIAVTTAVMLLISLLLIPNPLCSLWVTFSIASVIVGVTGFMALWDVNLDTISMIILVVCIGFSVDFSAHISYSFVSSKKLSANEKAVDALFSLGYPILQGAVSTIL-GVVVLSASKNYIFRTFFKIMFL-VIFFGLFHGITFIPVFLTFFDMCSGMYD--KVNKDKQGLEDQATGNSHGN 856
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Cavefish
Match: ENSAMXT00000043761.1 (patched domain-containing protein 3-like [Source:NCBI gene;Acc:103042169]) HSP 1 Score: 146.362 bits (368), Expect = 5.242e-35 Identity = 180/741 (24.29%), Postives = 324/741 (43.72%), Query Frame = 1
Query: 1744 WEKAFLNVV-QNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLC------CVRMNNVVTPVDAVPVAKVKYSGI-----LHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGSFCPASVVNSTCNNCP-------ANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVF---YVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSF---CGPALNRKKIVEQKKLLEKMPENNSWGN 3891
W FL V N S + S + R V+ E + + LF+I +Y+I + ++ +++ ++ +KV + VL ++V S G ++ VP + + PFL+L +GVD++FIL+ +Q+ ++ + E ++A + S+ +++L++ LAF+ G+MT +V+ F LY +T++LF ++ IT A L+L+ +R + + C C + + V A ++G ++ F K+Y P L K+ + V++ YM+ YL+V F +K+G + ++ + + +EK+ + + PN+ I S S+ D+ S C + + SF + S + N +A+H VF D L FL ++ + Q VN N I A+ F + T D L L ++ Q VP V+ +++++QY + IQ V+L+ +LL + +L + F I ++ + GFM LW + ++ +SM+ LV+ IG SV+F AHI ++V + + E+A + L +G +L G T L G++VL+ SK+ +F+ F+ M+L ++ FG H I F+PVFL+F C + K+ + K+ LE NS GN
Sbjct: 222 WLNEFLKVFPSNLSTKFIKVTYSTSLSRQVEFEANTKDVIPLFSI--TYVIAIAFSILSCLRFDCVR-----NKVWVATFGVLSAGLAVLSSFGMMLHIGVPFVMTVANS-PFLILGIGVDDMFILISCWQQ-----TNVHDQVEDRLANTYKEAAISITITTLTDVLAFYIGLMTPFRSVQSFCLYTSTSILFCYIYSITFFGAFLVLNGRRENRNQHWLTCKEVPEECPTDQSKWHELCCVGGAYDLHTGSEEVQPMNHFFKKYYGPFLTKSWTKVFVILL-----------------------------YML--------YLTVSIYGCFQIKEGIDLRNLAADDSYVVRYYDDEKA-----YFSEYGPNIMVIVRSEFSYWDE----KNMSDLESCVEDFKNLSFIEKDIFTSWIKSYKYYGYHKNLNLSAEH-----VFKDNLGTFLR----------FYSDFRQDVNFTNN--------SIYASRFFIQTVNISTALDEMNMLNK---------------LRDTAQRCPVPLLVYHPAFIYHDQYAVIVSNT-IQNIAVTTAVMLLISLLLIPNPLCSLWVTFSIASVIVGVTGFMALWDVNLDTISMIILVVCIGFSVDFSAHISYSFVSSKKLSANEKAVDALFSLGYPILQGAVSTIL-GVVVLSASKNYIFRTFFKIMFL-VIFFGLFHGITFIPVFLTFFDMCSGMYD--KVNKDKQGLEDQATGNSHGN 860
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Sea Lamprey
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161]) HSP 1 Score: 946.421 bits (2445), Expect = 0.000e+0 Identity = 552/1285 (42.96%), Postives = 782/1285 (60.86%), Query Frame = 1
Query: 112 CIWYGQCDKSNPN--KILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV-DTGY----GGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNA--PFQINYL------NEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPA---------TPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTK--LEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIK-PTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMA--IGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKI---VEQKKLLEK 3864
C+WYG+C NP K NC Y G KPL + G++ L +LCP + + N S CCN QL TL ++ CP+C N + YC LTC NQ F+ V T Y G SI + Y +++ F G+FNSC +V S+N A+ +CG + C+ + + + +TSN PFQI+ + + + MN L CN + +D G CSCQDC C P P +TI G+D V I+ + + +F I +SI + ++ K+ + PA + +S F++ G + E+ L F RWG L VL +++ V S G+ L +TTDPVELWS+PSS ARR KDYFD FGPF+RTEQ+II D T+ Y S + +GP +D+L +V L + MEV +N TK L+DIC PL+P C ++SV+ YFQN+ QL+R V D+F + A Y + C++ PT++ T + C G FGGPVFP+LA GG+ D NY ++TALVITF V N NS+++ A L WE+ F+++V+N++ N +L I Y+AERS++DEI+R+S D+ T+ +SY +MF Y+++ LG +I + VDSK++L + + IVL SV+ S+G +SY +P+TLI++EV+PFLVLAVGVDN+FILVQ YQR + K ++I R++ + PSMLL+S SE+LAFF G +++MPAV+ FSL+A AVL DFLLQ+T ++++ LDA+R E D++CC++ +VP G+L F +AP+L VR +V+ FV F+++ ++ I + L+Q+LSMP DSY++ YF AL +L GPPVYF+V+DG++Y + QN+ICG GCN SL+ QL++A+Q PN T I + +SW+DD+F W K + CCR++ G FC AS+ C C P K RP F +L FL++NPSM C KGGHAAYG AV++ + SH +GATYFM+YHTIL D+ AL+N+ IA ++T L TL +++ V YSVFYVFYEQYLT+ L + LG V LV+ +LLGL+ + L L I +I+ M G M+LWGI +NA+S+VNLVM +GISVEF +HIVRA+ V TR RA+E L MGSSV SGIT+TK GGI+VLAFSKSQ+F+IFYFRMYL +V+ GAAH +IFLPV LS+ G +N+ K+ +E++K E+
Sbjct: 26 CVWYGECGL-NPQTQKAYNCFYNGTAKPLPHE-GYELLKELCP--SMVQENVSTCCNVKQLRTLKENMALPLQFLSRCPSCFYNLMTFYCELTCSVNQSTFLNVTQTEYSNTTGTSITRLQYYISKTFANGMFNSCKDVTSPSSNDKALGLLCGRDAKDCNATNWIEYMC-STSNGQTPFQIDPVFTDAPEDPMVPMNVATLGCNKSVDDDTGP-CSCQDCALMCGPKPQPPPTPPPWTIFGLDAMVVIMVLSYMSFLWIFLSIVVCMFCYYRKFFT-----VTPAHMVYSFSNNAGDTQSVSLFERLGERFESSLREGFARWGATCVLHPLPVLLCSLVLVAVCSAGLALMTITTDPVELWSAPSSQARREKDYFDSKFGPFFRTEQLIIQAIDMNSSTYSPYP-SGNAVPFGPPLGLDILFQVLDLQTAVEMMEV----PHNGTKVTLKDICLAPLAPTNNNCTIISVLNYFQNSYKQLNRTVGDDFFV-WADYHSHFLYCVRAPTSVNDTTPLHDPCLGTFGGPVFPWLALGGY-DGDNYNNATALVITFPVVN-YHNNSEKMAAILAWEQGFIDLVKNYN--NPNLSIVYSAERSIEDEINRESTGDVRTVLISYAVMFVYISLALGHIRSIFTLAVDSKISLAMAGIAIVLCSVSSSLGIFSYAGIPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERRAEEK---AHEQIGRILGDIAPSMLLTSTSETLAFFLGALSDMPAVRTFSLFAGMAVLIDFLLQVTCFVSLMGLDARRQEEGHFDIVCCLK--------TSVPPPDESQHGLLFRFFKNLFAPVLLSECVRPVVMSVFVAALAFSVAVVNKIEIGLDQRLSMPDDSYVLTYFTALNRFLHSGPPVYFVVEDGHDYLTLEGQNVICGGVGCNNNSLVEQLYLAAQLPNYTRIGYAPSSWIDDYFDWVKPQSS--CCRVFNSTGDFCNASLPGPDCVPCRPLTREGKQRPLGDNFTHFLPMFLSDNPSMYCAKGGHAAYGSAVSV----NGSH----VGATYFMSYHTILTESGDFIAALRNARTIATNITAALGPTL---SKYRVFAYSVFYVFYEQYLTIVNDTVFNLSLSLGAVFLVSILLLGLEVWSALTLTLTIAMILTDMLGVMWLWGISLNAVSLVNLVMTCCVGISVEFCSHIVRAFSVSTQPTRALRAKEALAHMGSSVFSGITVTKFGGIVVLAFSKSQIFKIFYFRMYLSMVLLGAAHGLIFLPVLLSYVGAPVNKAKVLAALERRKGTER 1265
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Sea Lamprey
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7898]) HSP 1 Score: 330.102 bits (845), Expect = 2.443e-98 Identity = 226/678 (33.33%), Postives = 349/678 (51.47%), Query Frame = 1
Query: 202 TGF--QTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGSIQAV------TYNL--NENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINY---------LNEVKGMNQ---TMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEK---CAVMSVMQYFQNNITQLDRIVT---DEFNLPIATYMDQIMEC-IKDPTNIKPTKFKEI-CNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNT-DLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQR 2136
+GF + L LCP K + N + CC DQL++L + + I CP+C+ NF L+C C P+Q +V V + + V +N + F SC +V + + +AID +CG C + GD ++ AP I + E +GM Q T C E DG ACSCQDC +CP+ PPP P + +D + I +VF ++ +L + + T + + L F RWG+ VA + V+ +++ LS+G++ ++TTDPVELWSSPSS AR+ K++ D NFGPF+RT Q+I+ K + + +N + ++LL + L + ++EV + L+DICF PLSP+ K CAV S++QYFQNN T+L D + A + D M C + P + K E+ C D+G PVFP+LA GG+ D++ +T+S AL++TF NN ++ + + L WE F+ V + + T + + + AERS++DEI+R + DL A+SY ++F Y+ + LG+Y++ K++ +DSKVTLGL + +VL SV ++G ++Y VP +L+ILEVVPFL+LAVG DN+FI V +R
Sbjct: 39 SGFALELLRDLCPMLYKGEGNTTACCGNDQLVSLKNSMDLSVPILARCPSCLYNFRLLHCTNICSPDQSLYVNVTRTFETVVDGVNKTGVLAFNCLYTRRLAEEAFESCQSVAIPATGGFAIDAMCGVFGSTLCTAQRWLDFQGDISNGLAPIDIVFDLIPDGETAPQESQGMRQFNDTTFKCT-EAVEVDGPACSCQDCVKACPSVPPPPDPPGPWMFGRLDAPLAIGLVVFAGLTLLFTVFAALSHL------------LGRGRSKGGGGGTSESWARTRQGLLAAAFRRWGVLVAHNPIPVIIASVVVVAALSVGLVFIELTTDPVELWSSPSSRARQEKEFHDANFGPFFRTNQLILRSKGGKGSLYKSVLFGTQN--FSSTLQLNLLLELLELQTQLQDIEV--DVNGTAVSLKDICFAPLSPEQPKDTDCAVNSLLQYFQNNRTRLLATAEQKGDGGQMGTADWHDHFMYCSFRSPLSFKDVTALELSCMADYGAPVFPFLAVGGYHDER-FTESEALILTFSTNN-FARDHPKFEFVLAWEAEFIRRVHKYKDDPTSNFTVVFMAERSLEDEINRTTAEDLPIFAISYAVIFAYIALALGEYSSWKRVLIDSKVTLGLGGIFVVLASVAAAMGVFAYAGVPSSLVILEVVPFLILAVGADNIFIFVLELRR 697
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Sea Lamprey
Match: scap (SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-41]) HSP 1 Score: 68.9366 bits (167), Expect = 8.662e-12 Identity = 58/204 (28.43%), Postives = 100/204 (49.02%), Query Frame = 1
Query: 1777 FSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIP-VDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSE 2385
+ TN L Q+E+ +L + +YII+F Y+ Y + +KI V SK L L AV V+ S+ SVG + + TL E+ P+LVL +G++N+ +L ++ + + + +IA+ +S G S++ + +E G T +PA++ F L+A ++ DF LQ+ VL +D +R E
Sbjct: 263 YPATNASLREDSMVHVHFQEEV---GVAELVPLVTTYIILFAYI------YFSTRKIDLVKSKWGLALAAVATVISSLLISVGLCTLFGLTPTLNGGEIFPYLVLVIGLENILVLTKSV-----VSTPVDQDVKFRIAQGLSNEGWSIVKNMATELFIVLIGYFTMVPAIQEFCLFALVGIVSDFFLQMFFFTTVLAIDIRRME 452
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Yeast
Match: NCR1 (Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p [Source:SGD;Acc:S000005927]) HSP 1 Score: 431.795 bits (1109), Expect = 6.847e-131 Identity = 359/1247 (28.79%), Postives = 586/1247 (46.99%), Query Frame = 1
Query: 112 CIWYGQCDKSNP-NKILNCN--YTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS-----IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDAT---SNAPFQINYLNEVKGMNQTMLPCN--MNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDY--GNGIVPATPEVDDIST-----FDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVT--TDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGT-SGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPD-GSFCPASVVNSTCNNC----PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEM---GSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVI 3759
C YG C K + L C + P L++ T + L ++C + K R CC DQ++ L L A + CP C++NF L+C TC +Q FV + + + +N ++ ++SC N+ S+ N YA+D + G F K LGDA +PFQINY ++ + N + +D C+C DC+ SCP P + L ++ A F +++ YL K K + + IVP + +D+ T F+ L F + G F +L + V S II + T TDP+ LW S +S + K+YFD+NFGPFYRTEQI +V + GPV + + L + N I+ E+ S Y +D+CF+P + C + S QYFQ + D ++ ++ EC K P N PT F P+ L F + ++ A V+T ++ N ++A WE+ + + + L IS+ E S++ E++ + D+ T+A+SY++MF Y T L + + +++ LG+ +LIVL S+ C+ GF + + TLII EV+PFL+LA+G+DN+F++ Y R E + +QKI + ++ PS+L+S L ++ F MPAV F++Y+ +V+F+ +LQ+T +++L L KRS ++ N T FY ML + + L++I F W +L + I L+Q L++P+DSY+++YF + ++L+VGPPVY +VK+ K +N Q ICG + C SL L Q + + I+ A+WLDD+F++ N CCRL CP S + C C N+ P+ K F +YL+ ++ N PS CP GG A Y A+ + + A+ F T H L++ D+ +A + + I++S E ++ YS FY+F+ QY T+ L ++L +++ + + +++ +L + +I+ + M L GI +NA+S+VNL++ +G+ VEF HIVR++ V S+T+ + VL + G SV+ GITLTK G+ VLAF++S++F +FYFRM+ ++I
Sbjct: 23 CAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETS-KLLVEVCGEEWKEVRYA--CCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQ---FLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFA-----FMWYYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSF-IIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNET------------------GPVLSYETLHWWFDVENFITE-ELQSSENIGY---QDLCFRP--TEDSTCVIESFTQYFQGALPNKD------------SWKRELQECGKFPVNCLPT---------FQQPLKTNLLFS----DDDILNAHAFVVTLLLTN-------HTQSANRWEERLEEYLLDL-KVPEGLRISFNTEISLEKELNNNN--DISTVAISYLMMFLYATWALRRKDG------KTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCE--QKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQI-------TGNEETK---------------ESFLKTFYFKMLTQ---KRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQK-ICGKFTTCERDSLANVL---EQERHRSTITEPLANWLDDYFMFLNPQ-NDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWI-NAPSDPCPLGGRAPYSTAL--------VYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPE-----------LDMFAYSPFYIFFVQYQTL-GPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLII 1139
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Nematostella
Match: EDO42868 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0G1]) HSP 1 Score: 884.789 bits (2285), Expect = 0.000e+0 Identity = 535/1288 (41.54%), Postives = 755/1288 (58.62%), Query Frame = 1
Query: 115 IWYGQCDKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGS------IQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSN--APFQINYLNEVKG----MNQTMLPCN---MNGGEDDGEA-CSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKY----DKDYGNGIV--PATPEVDDIST--------FDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDI--SARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTK---LEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRI-VTDEFNLPIATYMDQIMECIKDPTNIKPTKFKE-ICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSE--TNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-------------PDGS--FCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGP 3816
+WYGQC K LNC Y P K LN+ L LCP+ A+ + CC+ QL LD L+ CP C +N + +YC TC P+Q F+ + G I + Y + LF SC +V+ N ++ +CG + E C P + +G +TSN APF I+Y ++ MNQT C+ +N + A CSCQDC+ SCP PP K TI+G+ F++ +VF FF++ + I + K Y D G+V P + I+ F+ G +E L F WG++ + V++ I+ +L+ G+ + DPV+LWS+P S AR+ KD FD F PFYRTEQ+II P Y + + +GP+F++DLL + L N++++M V N T LED+CFKPL+P KC + SV QYFQN+ L++ TD F+ + D I+ C PT+++ K+ C G+ G PV P +A GGF + +Y +++AL+ITF+V N D+ K+ A WEKAF++ ++++ + N++L IS+++ERS+QDE+DR+SETD+ TI +SY IMF Y+TI LGQ N+ ++I +DSK TLG C ++IVL SV CS+GFWSY+ VP TLII+EV+PFLVLAVGVDN FI+VQ YQR + Y N +KI+ + +V PSMLLSSLSES+AF G M++MPAVK+FSLYA+ AV DF+LQIT +A++ LDAKR E R D++CCV+ + G +++I FYAP L VR V++ F G +++ I V L+Q +++PKDS+++++F + YL VGPPVYF++ Y+++ +QN ICG++GC+ SL+ Q+F AS N + I+ +SWLDD+F W S CCR+ P+G FC A+V N C C RP FD YL F+L +NP + C KG Y + N N + A+YFM+YHTILKT D+ ALKN+ EIA ++T T LG+ + +V PYSVFYVFYEQYLT W L C+ V +VTF+ +G + LI+ F + +I+ ++ G MYLW I +NA+S+VNLVMA+GISVEF +HI RA+ V +T+ ERA E L+EMGSSVLSGITLTK GGIIVLAF+KS++F+IFYFRMY+GIV+FGA H ++FLPV LS+ GP
Sbjct: 2 VWYGQCTKPGQTPALNCLYNEPAKELNDTKAMNILKNLCPKIAQGGKT---CCDLRQLEALDSNLNTLRQFTSRCPACWQNMLDMYCESTCSPDQSLFMDPTSVVGFPPYTPYMINTINYYIAPEHKDQLFKSCKDVIFPGNNEKILNLLCGQSAETCSPQKLLEYMG-STSNGQAPFDIHYPEIIRPNMTWMNQTSYKCSESFINPLTNRTSAKCSCQDCQGSCPVLPPEPPTPKQKTIIGLSILSFVLLVVFIGFFILFMGISCYKIFNKPAYMRLPDNVVARGVVYTEERPPSNVINVEIARKPGCFEVMGVAMEQKLRKIFSLWGLWCSNHPYTVIAGCIVFVGILAGGVGYYSIIKDPVKLWSAPQSRARQEKDLFDSKFSPFYRTEQLIITVNQNYPQNHTGYKQYPDDKFIPFGPIFHLDLLNQALDLQNYLTDM-VVPHTENGKTTNITLEDVCFKPLAPLNTKCTIQSVFQYFQNSKELLNKCRTTDYFH---DDFHDHILYCTSAPTSLEDFKWGGGPCLGENGVPVNPNIALGGF-EGTDYNNASALIITFVVENHRDE--KKNAKAESWEKAFIDHMKSYVKHPENSNLTISFSSERSIQDELDRESETDIATILVSYTIMFVYITIALGQINSCERIMIDSKFTLGFCGIIIVLCSVICSIGFWSYVGVPATLIIIEVIPFLVLAVGVDNFFIMVQAYQRINRY---SNEPVSKKISCALGEVAPSMLLSSLSESVAFGFGAMSDMPAVKVFSLYASFAVAVDFILQITWFVALMSLDAKRQETNRWDIMCCVKQKKT---------EHREQDGFIYQIMKHFYAPALLSDFVRPCVIVLFTGMLFTSIALTPHISVGLDQDIALPKDSFLLDWFKDMRQYLHVGPPVYFVLDGKYDFEHSKTQNRICGSAGCDPDSLIQQVFTASLRSNRSKIAMPASSWLDDYFNWIDPSTT--CCRILYENTTSGVVPAKGPNGGLVFCNATVKNDLCMPCMNKSQQGERPTPSEFDMYLPFYLKDNPELVCAKG----YVMSPN-GNIFLLISLMLSPSASYFMSYHTILKTSDDFISALKNAREIADNMT----TALGDPD-IKVFPYSVFYVFYEQYLTAATNAWKNLLYCIAAVFVVTFLWMGFNLSIALIVTFTVAMIITNLLGLMYLWSISLNAISIVNLVMAVGISVEFCSHIARAFAVNTRNTKRERAEEALIEMGSSVLSGITLTKFGGIIVLAFAKSRIFEIFYFRMYVGIVLFGALHGLVFLPVLLSYVGP 1254
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Nematostella
Match: EDO36972 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH24]) HSP 1 Score: 119.398 bits (298), Expect = 3.272e-27 Identity = 91/374 (24.33%), Postives = 178/374 (47.59%), Query Frame = 1
Query: 1639 FGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVL-CCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMI 2757
+ + T ++A+ +T+++ D + + ++E F+N ++ + + + YTAERS+ D I + +D+ I++++ +M T+ LG++ N P+ L V V + V G + +P + ++ V+PFL+L +G+D++FILV R D L+ I V+ G ++ ++++++ +AF T P+++ F +YAA +V +L+ IT +A+ D +R +A R D L CC P + P +++ K YA +L KTPVR LVV+ +G ++ I +++L +SY + +A + + V ++ +Y Q+ I
Sbjct: 184 YNSNGHLTSASAIQVTYLIQAPTDTDVED--KVFEFETDFINKMKGLQKDLSCAKMFYTAERSLDDAISESAGSDITLISITFAVMITFACTMLGKFCN----PLTGHSLLANAGVFAVALGVLAGFGLSLAVGIPF-ISLVGVLPFLILGIGIDDMFILVDELDRQD-----NKLSVIDTIKMVMRHSGMTVTMTTVTDLVAFAVSTSTAFPSIRYFCIYAALSVTLSYLMIITYFVAIATFDVRRIKANRRDCLPCCF----APIPKEGEPKWDEPRLQGANKVM-KQYARLLMKTPVRILVVLLSMGLLGISIWGAMNISESFDRRLLAKDNSYFKEFINAQERHYELSLEVSIVMDAKLDYGMARIQDDI 540 HSP 2 Score: 83.9593 bits (206), Expect = 2.770e-16 Identity = 67/180 (37.22%), Postives = 105/180 (58.33%), Query Frame = 1
Query: 3271 NSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLI--LGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLS 3804
N + P S F++F+EQY ++ + I+ +L+ L + TL+ LGF +++ +F M +W + +NA+SM+NLVMAIG SV++ AHI A+V T R L +G+SVL G T LG I+ + S S++F+IF F+M+LGIV+ G H ++FLPV++S
Sbjct: 642 NDKSLKAYPISRFFIFFEQY-SLIQSETIRNLAIAAAAVLLITWPFLLSIRVTLLVFLGFSALIV--ELFALMSVWDVSLNAISMINLVMAIGFSVDYSAHIAHAFVTSSEPTAELRVEHALSTLGTSVLLGGISTFLGMIVTVG-SSSKIFRIF-FKMFLGIVLLGLLHGLVFLPVYMS 816
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Nematostella
Match: EDO39186 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAU6]) HSP 1 Score: 118.242 bits (295), Expect = 3.722e-27 Identity = 91/374 (24.33%), Postives = 178/374 (47.59%), Query Frame = 1
Query: 1639 FGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVL-CCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMI 2757
+ + T ++A+ +T+++ D + + ++E F+N ++ + + + YTAERS+ D I + +D+ I++++ +M T+ LG++ N P+ L V V + V G + +P + ++ V+PFL+L +G+D++FILV R D L+ I V+ G ++ ++++++ +AF T P+++ F +YAA +V +L+ IT +A+ D +R +A R D L CC P + P +++ K YA +L KTPVR LVV+ +G ++ I +++L +SY + +A + + V ++ +Y Q+ I
Sbjct: 3 YNSNGHLTSASAIQVTYLIQAPTDTDVED--KVFEFETDFINKMKGLQKDLSCAKMFYTAERSLDDAISESAGSDITLISITFAVMITFACTMLGKFCN----PLTGHSLLANAGVFAVALGVLAGFGLSLAVGIPF-ISLVGVLPFLILGIGIDDMFILVDELDRQD-----NKLSVIDTIKMVMRHSGMTVTMTTVTDLVAFAVSTSTAFPSIRYFCIYAALSVTLSYLMIITYFVAIATFDVRRIKANRRDCLPCCF----APIPKEGEPKWDEPRLQGANKVM-KQYARLLMKTPVRILVVLLSMGLLGISIWGAMNISESFDRRLLAKDNSYFKEFINAQERHYELSLEVSIVMDAKLDYGMARIQDDI 359 HSP 2 Score: 72.4034 bits (176), Expect = 8.589e-13 Identity = 45/132 (34.09%), Postives = 71/132 (53.79%), Query Frame = 1
Query: 3271 NSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLI--LGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSG 3660
N + P S F++F+EQY ++ + I+ +L+ L + TL+ LGF +++ +F M +W + +NA+SM+NLVMAIG SV++ AHI A+V T R L +G+SVL G
Sbjct: 461 NDKSLKAYPISRFFIFFEQY-SLIQSETIRNLAIAAAAVLLITWPFLLSIRVTLLVFLGFSALIV--ELFALMSVWDVSLNAISMINLVMAIGFSVDYSAHIAHAFVTSSEPTAELRVEHALSTLGTSVLLG 589
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Nematostella
Match: EDO46942 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNK5]) HSP 1 Score: 115.546 bits (288), Expect = 8.147e-26 Identity = 105/390 (26.92%), Postives = 178/390 (45.64%), Query Frame = 1
Query: 1741 DWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNV---PMTLIILEVVPFLVLAVGVDNLFILVQTYQRYD-EYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPV--YFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQS 2892
DWEK F ++ N T + Y + + D + D+ ++ Y+++ YV I LGQ+ ++ K LG+ V+ V +S+ S G S V P + V+PFL+L +GVD++F++VQ + E + +K + ++IA + G S+ ++SL++ LAF G T +P ++ F +YA +L DF+LQIT+ A L LD +R + R CC +V PVD ++ ++ F+ +Y + P + +V+I + LF LS L L + +D FDA+ +L Y I D + S + G E L + + +S SW DD+ W+K++
Sbjct: 816 DWEKEFGKILDNLPSTAPGTYY-YFSRYTFSDAAGNSIQGDVTLLSAGYMLIIVYVVIMLGQFTRLRL-----KAWLGVAGVICVGLSIGVSFGMSSAFGVFYGP----VHSVLPFLLLGIGVDDMFVIVQAWNNLTPEEHKTKEV--HERIALTLQHAGCSITITSLTDFLAFLIGASTVLPGLQSFCIYAGLGILIDFILQITLFSAFLTLDGRREDRKRDGCCCCC----IVLPVDYTE-SQCGSRELMKVFFESYYCKAILSLPGKVIVMI--ITGVLFGLS--------LYGTLMLKQD------FDAIW-FLPTKSMAYKYTIENDKFFPSSGERAALYAGKINYFEDQLKLHKLREVTIADSGVVDSSVKSWFDDYMDWAKKT 1171 HSP 2 Score: 85.8853 bits (211), Expect = 8.884e-17 Identity = 51/152 (33.55%), Postives = 85/152 (55.92%), Query Frame = 1
Query: 3475 GFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPA-------------LNRKKIVEQKKLLEKMPENNSWGN 3891
GFMY WG+ I+ ++ + LV+A+G++V++ +HI +++ T +RAR + +MG +VL+G T L ++LA S S +F +F F+++ +V+FG H + +LPV LS GPA R V K ++PE N+ G
Sbjct: 1309 GFMYFWGLTIDTITTIQLVLAVGLAVDYSSHIGHMFMIT-PGTHEDRARITMRDMGPAVLNGGFSTFL-AFVLLAASDSYIFGVF-FKIFFLVVLFGMWHGMAYLPVLLSSIGPAPYLSAQVSDRHNKSGRASPVHPKSENVELPEKNTRGQ 1457
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Nematostella
Match: EDO32433 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SV27]) HSP 1 Score: 111.309 bits (277), Expect = 1.742e-25 Identity = 70/201 (34.83%), Postives = 120/201 (59.70%), Query Frame = 1
Query: 3247 EQLKTTLGNSNQFEVVP---YSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLS-FC--GPALNRK 3831
+ + T + ++F VP S ++++EQY + ++ V G+ +LV +D T+++ F + ++ +FG MY+WG+ +N +SM+NL+MAIG +V++ AHI AYV+ +R + L +G+SVL G T + G+++LAF+ SQ+F+IF F+M+ GIV G H + FLPV+L+ FC P +R+
Sbjct: 273 DAMVTLREDVDEFSTVPAYPISKPFLYFEQYAITLRAT-VRNLVIAGIAILVITCPFLVDLSVTILVFFGFVALVFELFGLMYVWGVSLNGVSMINLIMAIGFAVDYSAHIAHAYVMSSKALPEDRVVDALRTLGASVLMGGASTFI-GMVMLAFASSQIFRIF-FKMFFGIVFLGLLHGLCFLPVYLTIFCRSAPTSHRE 470
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Medaka
Match: npc1 (NPC intracellular cholesterol transporter 1 [Source:NCBI gene;Acc:101159535]) HSP 1 Score: 938.717 bits (2425), Expect = 0.000e+0 Identity = 540/1268 (42.59%), Postives = 770/1268 (60.73%), Query Frame = 1
Query: 109 KCIWYGQC-DKSNPNKILNCNYTGPPKPLNNATGFQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKAL-GDATSNAPFQINYL---NEVKG---MNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIY-LKKNKYDKDYG---NGIVPATPEVDDI-----STFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKF-KEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLY-PDGSFCPASVVNSTCNNC-PANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKK 3852
CIWYG+C D P K NCNYTGPP PL + LT+LCP Y +R SLCCN +QL TL L CP C N + L+C LTC P+Q F ++ V Y + + F ++N+C +V S+N A+ +CG ++C+ + + + + APF IN + EV G MN C G ED CSCQDC +C P P +TI G+D I+ + +F ++ + + + ++ +YG + P + DD+ S + G + E +L + F WG F R +V+ +++ + S G+ ++TTDPVELWSSP+S AR+ KDYFD +FGPF+RT Q+II + FT+ Y N+ + P+F+ +LL +V L ++ + + L+DIC PL+P C ++S++ YFQN+ + LD I DEF A + + C+ P ++ T + C G FGGPVFP+LA GG+ D NY ++TALVITF +NN L+ +S ++ L WEK F+ ++NFS N++L ++++AERSV+DEI+R+S +D+ TI +SYIIMF Y+++ LG ++ VDSK++LG+ +LIVL SV+ S+G +SY +P+TLI++EV+PFLVLAVGVDN+FI+VQT QR D N Q+I R++ V PSM LSSLSE++AFF G ++ MPAV+ FSL+A A+ DFLLQI+ +++L LDAKR E R+D+ CCV++ ++K GIL F K YAP++ + VR ++V FVG F+++ ++ + + L+QKLSMP DSY+++YF L+ YL G PVYF+V+DG NY S + QN++CG GCN SL+ Q++ AS N T I+ + +SWLDD+F W K CCR Y G FC ASV+N +C +C P K RP + F +L FL++NP+ +C KGGHAAY AV++K D +GATYFMTYHTILK D+ ALK +A ++++ + N F YSVFYVFYEQYLT+ + LGV L + +VT VLLG + + L++ I +I+ +MFG M+LW I +NA+S+VNLVM+ GISVEF +HIVRA+ + +R+ERA E L MGSSV SGITLTK GGI+VLAFSKSQ+FQ+FYFRMYL IV+ GAAH +IFLPV LS+ GP+ N+ K++ K
Sbjct: 31 HCIWYGECGDSPVPGKKFNCNYTGPPLPLE-PEAYDLLTELCPGYDYGNR--SLCCNANQLRTLKGSLQLPLQFLSRCPACFYNLMNLFCELTCSPHQSQFTKATKFNDSNVMEVQYYIGKTFASAMYNACSDVQAPSSNVKALSLLCGKVAQECNATNWIQYMFSTSNGQAPFPINPIFSDVEVSGFTPMNNKTYACT-EGLEDGSGPCSCQDCTNACGPKPIPPVVPPPWTIFGVDAMNVIMWFSYLSFLLVFLGAVLGAWCYRRRTVMSEYGPILDSNNPLSLNSDDLGQASPSCCETLGERFENFLRVLFSSWGSFCVRNPFVVILGSLLLVVAFSYGLRYMRITTDPVELWSSPASQARQEKDYFDSHFGPFFRTAQLIITTSTKNNFTYSPY-FGGSNVPFKPIFDKELLHQVLDL--QLAIQSLVATYEGQNVTLKDICVAPLAPYNNNCTILSILNYFQNSHSVLDHIAGDEF-FTYADFHSHFLYCVSAPASLNDTTLLHDPCLGTFGGPVFPWLALGGY-DDTNYNNATALVITFPLNNYLN-DSVRLGKVLAWEKEFIGFMKNFS--NSNLTVAFSAERSVEDEINRESNSDINTILISYIIMFVYISLALGHIHSFSMFLVDSKISLGIAGILIVLSSVSSSLGIFSYFGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTLQRDDRM---PNEELHQQIGRILGDVAPSMFLSSLSETVAFFLGALSIMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDAKRQERNRLDICCCVKLPES---------QQIKSDGILFRFFKKIYAPVILQEWVRPIIVAVFVGMLSFSIAAVNKVQIGLDQKLSMPDDSYVLDYFKNLSEYLHTGAPVYFVVEDGLNYTSLDGQNVVCGGVGCNNNSLVQQVYTASLISNYTTIAYTPSSWLDDYFDWIKPQST--CCRFYNSTGEFCNASVINPSCVSCRPMTPAGKERPVGEEFMRFLPMFLSDNPNPKCGKGGHAAYATAVDLKPNDGG------VGATYFMTYHTILKDSPDFINALKMGRVLAENISQSI-----NHKAFA---YSVFYVFYEQYLTIAYDTALNLGVSLAAIFVVTTVLLGFEVWSALMVSITIAMILVNMFGVMWLWDISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTKRSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFSKSQIFQVFYFRMYLAIVLLGAAHGLIFLPVLLSYIGPSPNKAKVLATNK 1258
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Medaka
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:NCBI gene;Acc:101160914]) HSP 1 Score: 756.518 bits (1952), Expect = 0.000e+0 Identity = 483/1297 (37.24%), Postives = 730/1297 (56.28%), Query Frame = 1
Query: 112 CIWYGQCDKSNPN-------KILNC-NYTGPPKPLNNATG--FQTLTKLCPQYAKLDRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV----DTGYGG----SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYLNEVKGMNQTMLPCNM---NGGE--------DDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDK---------DYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD---YEKCAVMSVMQYFQN---------NITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSET-NTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYP----DGSFCPASVVNSTCNN--CPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPAL 3822
C +Y +C + NP+ I+ C NY+ P + TG ++ ++CP + + N CC+ QL +L+ LS + + CP+C NF ++C TC PNQ V V + Y G ++ A + +N F + F SC NV L + +AI T+CG C P +Y GD+++ AP I++ + +KG + T LP + NG E CSCQDC+ SCP+ PPP P F + G+DG++ I I+ + +Y+F+ + + K D I +++ +K + +L+ F RWG +A L VL ++ VLS+G+ ++TTDPVELWS+P+S AR+ KD+ D++FGPF+RT Q+I+ D+ + + +N + + + DL+ ++ L I +E +S+ LN L+D+C+ PL+P CAV S+ QYFQN N+T+L VT E + + D ++ C+ P + K T C D+G PVF +LA GG+ D +YT++ AL++TF +NN ++ K K AL WEK FL +VQ++ + T+ +Y AERS++DEI+R + D+ +SY+++F Y+ + LG+Y++ K++ VDSK +GL +L+V SV S+GF+S++ +P +L+IL+VVPFLVLAVG DN+FI V YQR D + + T EQ I RV+ V PSMLL SLSES+ FF G ++ MPAV+ F+LYAA AVL DF LQ+T +A+L LDA+R R ++ CCV + + + G L + K+YAP L R V++ F+ ++ + + V L+Q+L+MP DSYM+ YF L Y VG PVYF+ K G+N+ SE N +C + GC++ SL ++ A+ P+++YI+ SW+DDF W CCRLY G FCPA++ + C A+ T+ RP ++F+ +L FL N P +QC KGG AY +V I EI A+ FM YHT L +YT AL+ E+A+S+TE ++ G S FEV Y++ VFYEQYLT+ + + +CL +V +LLGLD + L+ II+I+ G M LW I NA+S++NLV A+GISVEF++H+ R++ + TR+ERA E MGS+V +G+ +T L GI+VLAF+K+QL QIF+FR+ L I + G AH +IFLPV L++ G L
Sbjct: 20 CAFYDECGR-NPSLGDTLIPPIVPCLNYS----PARHLTGEHYRRFKEVCPMLDQGEENTYGCCSLGQLTSLERSLSLSKGVLNRCPSCAENFAHMHCMATCSPNQTVAVKVTKVMNVTYLGQPKDAVVAYSAYINNQFAETAFQSCKNVRLPATGGFAISTMCGRYGATLCTPQRWYDFQGDSSNGLAPLDIDF-HLIKGHDTTGLPEGVIPYNGQALKCNEVTPSGSEPCSCQDCKDSCPSLPPPPPPPAPFRLAGMDGFLLI-SIILSCVLICAFLLYVFVSFRMSSKKKKDQGGGKRKDKTKDIFQRKIHPSEVTCANKTSLVAQDFLSSLFQRWGTLMASYPLTVLLFSAVVVAVLSVGLKSIELTTDPVELWSAPNSQARQEKDFHDKHFGPFFRTNQLILTAPDKKGSIYDSLLFGKQN--FSGIVSKDLIIQLLELQQKIQQIEFWSEDLNRTASLKDVCYAPLNPSNPSLTDCAVNSLPQYFQNSLENINAKANMTELG--VTKEVD-----WRDHLIYCLNSPLSFKDITALGMSCMADYGAPVFTFLAVGGYEDD-DYTNAEALILTFSLNNFPREDPK-FKVALQWEKEFLKIVQDYQKNPATNFTFAYMAERSLEDEINRTTAEDIPIFMISYLVIFVYIAVALGEYSSCKRLLVDSKFLVGLGGILVVGCSVLASMGFYSWIGIPSSLVILQVVPFLVLAVGADNIFIFVLEYQR-DVRRAGE--TREQHIGRVLGHVAPSMLLCSLSESVCFFLGALSTMPAVRSFALYAALAVLMDFALQMTAFVALLSLDARRQVKNRCELFCCVSV--------SAKHSNKPNEGFLLPLMRKYYAPALLNRYTRIFVMVVFILMFCASIFLMLHVKVGLDQELAMPTDSYMLRYFSYLHKYFEVGVPVYFVTKRGFNFTSEEGMNAVCSSVGCDQFSLTQKIQYATNFPDLSYIAIPANSWVDDFIDWLNPGSR--CCRLYTLGPNQGEFCPANISSLLCGRKCMNASATSAIRPSVELFNRFLPDFLGNRPDLQCSKGGLGAYDTSVVIDGGG-------EIIASRFMAYHTTLTNSQEYTAALQKGRELASSITEAMRKVPGTSPDFEVFTYTLTNVFYEQYLTIVPEGLFNISMCLLPTFVVCCLLLGLDLLSGLLNLITIIMIVVDTVGVMTLWSIDYNAVSLINLVTAVGISVEFVSHMTRSFALSTKPTRVERAAEATANMGSAVFAGVAMTNLPGILVLAFAKAQLIQIFFFRLNLVITLLGLAHGLIFLPVLLTYFGTDL 1278
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Medaka
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:NCBI gene;Acc:101160914]) HSP 1 Score: 746.888 bits (1927), Expect = 0.000e+0 Identity = 469/1241 (37.79%), Postives = 704/1241 (56.73%), Query Frame = 1
Query: 250 DRNPSLCCNTDQLLTLDMQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTV----DTGYGG----SIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEK-CDPVAFYKALGDATSN-APFQINYLNEVKGMNQTMLPCNM---NGGE--------DDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDK---------DYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPD---YEKCAVMSVMQYFQN---------NITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKP-TKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSET-NTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYP----DGSFCPASVVNSTCNN--CPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPAL 3822
+ N CC+ QL +L+ LS + + CP+C NF ++C TC PNQ V V + Y G ++ A + +N F + F SC NV L + +AI T+CG C P +Y GD+++ AP I++ + +KG + T LP + NG E CSCQDC+ SCP+ PPP P F + G+DG++ I I+ + +Y+F+ + + K D I +++ +K + +L+ F RWG +A L VL ++ VLS+G+ ++TTDPVELWS+P+S AR+ KD+ D++FGPF+RT Q+I+ D+ + + +N + + + DL+ ++ L I +E +S+ LN L+D+C+ PL+P CAV S+ QYFQN N+T+L VT E + + D ++ C+ P + K T C D+G PVF +LA GG+ D +YT++ AL++TF +NN ++ K K AL WEK FL +VQ++ + T+ +Y AERS++DEI+R + D+ +SY+++F Y+ + LG+Y++ K++ VDSK +GL +L+V SV S+GF+S++ +P +L+IL+VVPFLVLAVG DN+FI V YQR D + + T EQ I RV+ V PSMLL SLSES+ FF G ++ MPAV+ F+LYAA AVL DF LQ+T +A+L LDA+R R ++ CCV + + + G L + K+YAP L R V++ F+ ++ + + V L+Q+L+MP DSYM+ YF L Y VG PVYF+ K G+N+ SE N +C + GC++ SL ++ A+ P+++YI+ SW+DDF W CCRLY G FCPA++ + C A+ T+ RP ++F+ +L FL N P +QC KGG AY +V I EI A+ FM YHT L +YT AL+ E+A+S+TE ++ G S FEV Y++ VFYEQYLT+ + + +CL +V +LLGLD + L+ II+I+ G M LW I NA+S++NLV A+GISVEF++H+ R++ + TR+ERA E MGS+V +G+ +T L GI+VLAF+K+QL QIF+FR+ L I + G AH +IFLPV L++ G L
Sbjct: 6 EENTYGCCSLGQLTSLERSLSLSKGVLNRCPSCAENFAHMHCMATCSPNQTVAVKVTKVMNVTYLGQPKDAVVAYSAYINNQFAETAFQSCKNVRLPATGGFAISTMCGRYGATLCTPQRWYDFQGDSSNGLAPLDIDF-HLIKGHDTTGLPEGVIPYNGQALKCNEVTPSGSEPCSCQDCKDSCPSLPPPPPPPAPFRLAGMDGFLLI-SIILSCVLICAFLLYVFVSFRMSSKKKKDQGGGKRKDKTKDIFQRKIHPSEVTCANKTSLVAQDFLSSLFQRWGTLMASYPLTVLLFSAVVVAVLSVGLKSIELTTDPVELWSAPNSQARQEKDFHDKHFGPFFRTNQLILTAPDKKGSIYDSLLFGKQN--FSGIVSKDLIIQLLELQQKIQQIEFWSEDLNRTASLKDVCYAPLNPSNPSLTDCAVNSLPQYFQNSLENINAKANMTELG--VTKEVD-----WRDHLIYCLNSPLSFKDITALGMSCMADYGAPVFTFLAVGGYEDD-DYTNAEALILTFSLNNFPREDPK-FKVALQWEKEFLKIVQDYQKNPATNFTFAYMAERSLEDEINRTTAEDIPIFMISYLVIFVYIAVALGEYSSCKRLLVDSKFLVGLGGILVVGCSVLASMGFYSWIGIPSSLVILQVVPFLVLAVGADNIFIFVLEYQR-DVRRAGE--TREQHIGRVLGHVAPSMLLCSLSESVCFFLGALSTMPAVRSFALYAALAVLMDFALQMTAFVALLSLDARRQVKNRCELFCCVSV--------SAKHSNKPNEGFLLPLMRKYYAPALLNRYTRIFVMVVFILMFCASIFLMLHVKVGLDQELAMPTDSYMLRYFSYLHKYFEVGVPVYFVTKRGFNFTSEEGMNAVCSSVGCDQFSLTQKIQYATNFPDLSYIAIPANSWVDDFIDWLNPGSR--CCRLYTLGPNQGEFCPANISSLLCGRKCMNASATSAIRPSVELFNRFLPDFLGNRPDLQCSKGGLGAYDTSVVIDGGG-------EIIASRFMAYHTTLTNSQEYTAALQKGRELASSITEAMRKVPGTSPDFEVFTYTLTNVFYEQYLTIVPEGLFNISMCLLPTFVVCCLLLGLDLLSGLLNLITIIMIVVDTVGVMTLWSIDYNAVSLINLVTAVGISVEFVSHMTRSFALSTKPTRVERAAEATANMGSAVFAGVAMTNLPGILVLAFAKAQLIQIFFFRLNLVITLLGLAHGLIFLPVLLTYFGTDL 1213
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Medaka
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:101166055]) HSP 1 Score: 112.464 bits (280), Expect = 1.950e-24 Identity = 69/238 (28.99%), Postives = 129/238 (54.20%), Query Frame = 1
Query: 1705 LDQNSKQIKAALD-WEKAFLN-VVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCC 2412
++ N ++ A L+ W++ + V+Q+ + ++ +S+T +++D + SE + +A Y++M Y +T+ +++ K S+ +GL VL+V +SV +G S L + +V+PFL L VGVD++F+L + E +K + E + + + G S+ L+S+S AFF + +PA++ FSL AA V+F+F + + + A+L +D R E R D+ CC
Sbjct: 372 INWNEEKAAAILEAWQRRYSEAVLQSVAANSSQRVLSFTTT-TLEDILKSFSEISVIRVASGYLLMLAYACLTMLRWDCAK-----SQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAF---SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRCDIFCC 600 HSP 2 Score: 63.5438 bits (153), Expect = 1.560e-9 Identity = 58/193 (30.05%), Postives = 100/193 (51.81%), Query Frame = 1
Query: 3295 PYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKMPE 3873
P ++F+EQY+++ L + + V L LV + L W A +I+ + L+ +FGFM L GI ++A+ +V L+ ++GI VEF H+ A++ D R +RA L M + VL G + L G+++LA S+ ++F + + + G + ++ LPV LS+ GP + +L PE
Sbjct: 1081 PNGYPFLFWEQYVSLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIV-LVLSLMTVELFGFMGLMGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGD-RHKRAVLALEHMFAPVLDG-AFSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGPYPEVSPADGRSRLPTPSPE 1270
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Medaka
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:101166055]) HSP 1 Score: 112.079 bits (279), Expect = 2.325e-24 Identity = 69/238 (28.99%), Postives = 129/238 (54.20%), Query Frame = 1
Query: 1705 LDQNSKQIKAALD-WEKAFLN-VVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCC 2412
++ N ++ A L+ W++ + V+Q+ + ++ +S+T +++D + SE + +A Y++M Y +T+ +++ K S+ +GL VL+V +SV +G S L + +V+PFL L VGVD++F+L + E +K + E + + + G S+ L+S+S AFF + +PA++ FSL AA V+F+F + + + A+L +D R E R D+ CC
Sbjct: 372 INWNEEKAAAILEAWQRRYSEAVLQSVAANSSQRVLSFTTT-TLEDILKSFSEISVIRVASGYLLMLAYACLTMLRWDCAK-----SQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAF---SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRCDIFCC 600 HSP 2 Score: 63.1586 bits (152), Expect = 1.989e-9 Identity = 55/174 (31.61%), Postives = 95/174 (54.60%), Query Frame = 1
Query: 3295 PYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGP 3816
P ++F+EQY+++ L + + V L LV + L W A +I+ + L+ +FGFM L GI ++A+ +V L+ ++GI VEF H+ A++ D R +RA L M + VL G + L G+++LA S+ ++F + + + G + ++ LPV LS+ GP
Sbjct: 977 PNGYPFLFWEQYVSLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIV-LVLSLMTVELFGFMGLMGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGD-RHKRAVLALEHMFAPVLDG-AFSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGP 1147
BLAST of Niemann-Pick disease, type C1 vs. Planmine SMEST
Match: SMESG000005000.1 (SMESG000005000.1) HSP 1 Score: 2373.2 bits (6149), Expect = 0.000e+0 Identity = 1196/1197 (99.92%), Postives = 1196/1197 (99.92%), Query Frame = 1
Query: 301 MQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNAPFQINYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCXXXXXXXXXSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISARNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPXXXXXXXXXXXAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQXXXXXXXXXXXXXXXXXXDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKMPENNSWGN 3891
MQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNAPFQINYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCPAPPPPQKPSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDIS RNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPSMLLSSLSESLAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQLGVCLGVVLLVTFVLLGLDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKMPENNSWGN
Sbjct: 1 MQLSPASIIFGGCPNCMRNFIRLYCALTCDPNQDNFVTVDTGYGGSIQAVTYNLNENFYQGLFNSCDNVVLSSANSYAIDTVCGTTHEKCDPVAFYKALGDATSNAPFQINYLNEVKGMNQTMLPCNMNGGEDDGEACSCQDCRASCPAPPPPQKPSKTFTILGIDGWVFIVDIVFGAFFMIVISIYIFIYLKKNKYDKDYGNGIVPATPEVDDISTFDKCGAKVEAYLTLWFYRWGMFVARRCLIVLSVGIIIAMVLSLGIILKKVTTDPVELWSSPSSSARRNKDYFDENFGPFYRTEQIIIVPKDRTPFTWINYDISPRNLTYGPVFNIDLLRRVGTLINHISNMEVFSKLLNNYTKLEDICFKPLSPDYEKCAVMSVMQYFQNNITQLDRIVTDEFNLPIATYMDQIMECIKDPTNIKPTKFKEICNGDFGGPVFPYLAFGGFGDKKNYTDSTALVITFIVNNALDQNSKQIKAALDWEKAFLNVVQNFSETNTDLHISYTAERSVQDEIDRQSETDLFTIALSYIIMFTYVTITLGQYNNIKKIPVDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPMTLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPSMLLSSLSESLAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSEAMRVDVLCCVRMNNVVTPVDAVPVAKVKYSGILHEIFDKFYAPMLFKTPVRFLVVIFFVGWNLFALSQIHLIPVELNQKLSMPKDSYMINYFDALATYLSVGPPVYFIVKDGYNYKSENSQNMICGTSGCNEKSLLGQLFMASQNPNVTYISTSGASWLDDFFIWSKQSGNPPCCRLYPDGSFCPASVVNSTCNNCPANFTAKHRPDAKVFDDYLAFFLTNNPSMQCPKGGHAAYGQAVNIKNKDDKSHKPVEIGATYFMTYHTILKTPSDYTEALKNSIEIAASVTEQLKTTLGNSNQFEVVPYSVFYVFYEQYLTVFKQLWIQLGVCLGVVLLVTFVLLGLDWKATLILGFHIILIMNSMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAAHAIIFLPVFLSFCGPALNRKKIVEQKKLLEKMPENNSWGN 1197
BLAST of Niemann-Pick disease, type C1 vs. Planmine SMEST
Match: SMESG000053118.1 (SMESG000053118.1) HSP 1 Score: 67.0106 bits (162), Expect = 1.051e-10 Identity = 47/144 (32.64%), Postives = 79/144 (54.86%), Query Frame = 1
Query: 3418 WKATL-ILGFHIILIMN-----SMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAA-HAIIFLPVFLSFCGPALNR 3828
W ATL + F IILI S+ +Y+ G + L +NL + +G++++++ H+ AY + R ER ++L EMG S+LSG++ T LG L F +++ +F F +++ IF A +++IFLP GP+ R
Sbjct: 726 WFATLNVHTFLIILIGTCLSTLSVTSLIYITGWNLGLLESINLTVVVGLTIDYLVHMGLAYNSSQKKHRDERTEDMLEEMGVSILSGMS-TTLGSSFFLFFCQTKF--LFQFGVFVFATIFSAGIYSMIFLPCMFLVFGPSQGR 866
BLAST of Niemann-Pick disease, type C1 vs. Planmine SMEST
Match: SMESG000053118.1 (SMESG000053118.1) HSP 1 Score: 66.2402 bits (160), Expect = 1.431e-10 Identity = 47/144 (32.64%), Postives = 79/144 (54.86%), Query Frame = 1
Query: 3418 WKATL-ILGFHIILIMN-----SMFGFMYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAA-HAIIFLPVFLSFCGPALNR 3828
W ATL + F IILI S+ +Y+ G + L +NL + +G++++++ H+ AY + R ER ++L EMG S+LSG++ T LG L F +++ +F F +++ IF A +++IFLP GP+ R
Sbjct: 768 WFATLNVHTFLIILIGTCLSTLSVTSLIYITGWNLGLLESINLTVVVGLTIDYLVHMGLAYNSSQKKHRDERTEDMLEEMGVSILSGMS-TTLGSSFFLFFCQTKF--LFQFGVFVFATIFSAGIYSMIFLPCMFLVFGPSQGR 908
BLAST of Niemann-Pick disease, type C1 vs. Planmine SMEST
Match: SMESG000053129.1 (SMESG000053129.1) HSP 1 Score: 62.3882 bits (150), Expect = 1.583e-10 Identity = 37/111 (33.33%), Postives = 70/111 (63.06%), Query Frame = 1
Query: 3481 MYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAA-HAIIFLP-VFLSF 3807
+Y+ G + L +NL + +G++++++ H+ AY +++ +R +E+L EMG S+LSG+ T LG L F +++ +F F +++ I IF A +++IFLP +FL+F
Sbjct: 49 IYIIGWNLGLLESINLTVVVGLTIDYLVHMGLAYKSSEKESKEDRVQEMLGEMGISILSGMA-TTLGSSFFLLFCQTKF--LFQFGIFVFITIFSAGVYSMIFLPCIFLTF 156
BLAST of Niemann-Pick disease, type C1 vs. Planmine SMEST
Match: SMESG000053129.1 (SMESG000053129.1) HSP 1 Score: 64.6994 bits (156), Expect = 4.915e-10 Identity = 37/111 (33.33%), Postives = 70/111 (63.06%), Query Frame = 1
Query: 3481 MYLWGIPINALSMVNLVMAIGISVEFIAHIVRAYVVERSDTRIERAREVLVEMGSSVLSGITLTKLGGIIVLAFSKSQLFQIFYFRMYLGIVIFGAA-HAIIFLP-VFLSF 3807
+Y+ G + L +NL + +G++++++ H+ AY +++ +R +E+L EMG S+LSG+ T LG L F +++ +F F +++ I IF A +++IFLP +FL+F
Sbjct: 742 IYIIGWNLGLLESINLTVVVGLTIDYLVHMGLAYKSSEKESKEDRVQEMLGEMGISILSGMA-TTLGSSFFLLFCQTKF--LFQFGIFVFITIFSAGVYSMIFLPCIFLTF 849 The following BLAST results are available for this feature:
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Niemann-Pick disease, type C1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30027726 ID=SMED30027726|Name=Niemann-Pick disease, type C1|organism=Schmidtea mediterranea sexual|type=transcript|length=4069bpback to top protein sequence of SMED30027726-orf-1 >SMED30027726-orf-1 ID=SMED30027726-orf-1|Name=SMED30027726-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1284bp MKNILIFSVLIILLSFIHCKNDKCIWYGQCDKSNPNKILNCNYTGPPKPLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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