E3 ubiquitin-protein ligase RBBP6

Overview
NameE3 ubiquitin-protein ligase RBBP6
Smed IDSMED30027713
Length (bp)2017
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of E3 ubiquitin-protein ligase RBBP6 (SMED30027713) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase RBBP6 (SMED30027713) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase RBBP6 (SMED30027713) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase RBBP6 (SMED30027713) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027713

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30027713h1SMcG0022340 SmedASXL_004521SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30027713h1SMcG0022340 SmedASXL_004521SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30027713h1SMcG0022340 dd_Smed_v4_12318_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30027713h1SMcG0022340 dd_Smed_v4_12318_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Human
Match: RBBP6 (RB binding protein 6, ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:9889])

HSP 1 Score: 143.28 bits (360), Expect = 1.658e-37
Identity = 97/306 (31.70%), Postives = 161/306 (52.61%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPE-NFSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNC 939
            V+YKF S+LN   + F+G +IS+ +L   I  R+K   + C+L +   +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E   +      +++   SL  + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN +     ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQI--TNAQTKEEYT-DDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFE--SGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTC 299
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Human
Match: RBBP6 (RB binding protein 6, ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:9889])

HSP 1 Score: 145.976 bits (367), Expect = 1.357e-35
Identity = 102/330 (30.91%), Postives = 169/330 (51.21%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPE-NFSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  R+K   + C+L +   +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E   +      +++   SL  + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQIT--NAQTKEEYT-DDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 323
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Human
Match: RBBP6 (RB binding protein 6, ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:9889])

HSP 1 Score: 144.821 bits (364), Expect = 4.848e-35
Identity = 102/330 (30.91%), Postives = 169/330 (51.21%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPE-NFSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  R+K   + C+L +   +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E   +      +++   SL  + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQIT--NAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 323
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Human
Match: RBBP6 (RB binding protein 6, ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:9889])

HSP 1 Score: 144.821 bits (364), Expect = 5.018e-35
Identity = 102/330 (30.91%), Postives = 169/330 (51.21%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPE-NFSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  R+K   + C+L +   +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E   +      +++   SL  + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQIT--NAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 323
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Human
Match: RBBP6 (RB binding protein 6, ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:9889])

HSP 1 Score: 128.642 bits (322), Expect = 6.816e-30
Identity = 103/368 (27.99%), Postives = 170/368 (46.20%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPE-NFSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKN--------------------------------------RDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  R+K   + C+L +   +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E   +      +++   SL  + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   +                                      R+A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQIT--NAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAGRLLFHKLGTMGHKQIDTYFWNRGDVYGATATQITHLREAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 361
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Celegans
Match: rbpl-1 (Retinoblastoma Binding Protein Like [Source:UniProtKB/TrEMBL;Acc:O62235])

HSP 1 Score: 134.806 bits (338), Expect = 2.132e-32
Identity = 91/342 (26.61%), Postives = 163/342 (47.66%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDP---------------YKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNP---YGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNC-LGKIDKLDELIDDSELENLIHIW 1008
            ++YKF++EL+ + + F+G +I  ++L   I  K +       + +++  +K  +  S++ELIP  S++I++R P  D +K  K++   N    +++D                ++N +E E LN  +    + S+   +Q          +N+R   +R P    G PP TYTCN+C+ PGHW  NCP +             KR +GIP   L+E   + P++ + P G+YV+ I +     K +++      E+      Q   ++P  ++C +C +L      T+CC N+YC +CI   + DP+N     +CP    GK   +  +I +  L +    W
Sbjct:    4 IHYKFRAELDYKTLQFDGLHIRGEQLVREICAKENLKLELFELQLQNAHTK--KTYSDDELIPRNSSIIVQRFPRKDAAKVQKVQAGVNSGMVNQLDATSSFLDPSSHISSAEFENMDEAERLNHIR----DQSTRAYDQ----------SNFR---RRQPGIMTGPPPPTYTCNRCSQPGHWYKNCPML-----------NTKRTTGIPSQELMETTVDDPDAMMHPSGKYVIPIMH----WKARQETLARKNEDGSSSPAQTSRKVPPELLCPICQSLFKEAIVTSCCGNSYCADCIEARILDPDN----QKCPGADCGKDISITSIIPNKTLRDAAAAW 307
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Celegans
Match: rbpl-1 (Retinoblastoma Binding Protein Like [Source:UniProtKB/TrEMBL;Acc:O62235])

HSP 1 Score: 76.2554 bits (186), Expect = 1.348e-14
Identity = 53/188 (28.19%), Postives = 95/188 (50.53%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDP---------------YKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNP---YGTPPSTYTCNKCNIPGHWINNCP 549
            ++YKF++EL+ + + F+G +I  ++L   I  K +       + +++  +K  +  S++ELIP  S++I++R P  D +K  K++   N    +++D                ++N +E E LN  +    + S+   +Q          +N+R   +R P    G PP TYTCN+C+ PGHW  NCP
Sbjct:    4 IHYKFRAELDYKTLQFDGLHIRGEQLVREICAKENLKLELFELQLQNAHTK--KTYSDDELIPRNSSIIVQRFPRKDAAKVQKVQAGVNSGMVNQLDATSSFLDPSSHISSAEFENMDEAERLNHIR----DQSTRAYDQ----------SNFR---RRQPGIMTGPPPPTYTCNRCSQPGHWYKNCP 172
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Fly
Match: snama (gene:FBgn0086129 transcript:FBtr0307174)

HSP 1 Score: 112.464 bits (280), Expect = 6.099e-26
Identity = 93/333 (27.93%), Postives = 150/333 (45.05%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELT-DAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSM--TEEQKVDTVIESAATNY------RIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKFKS LN   I F+G +ISV +L  + +++K      +  + + +  SKEE    +  LIP  + +II R+P+   +K       A  EN     P K  N           N++ S M  TEE K+  ++  +  +Y      RI G+    G  P++Y CNKC   GHWI NCP +  K     D ++VKR +GIP         + P++       +V+                        P V+    EIPE+++C +C ++        CC +++C +C+   L + E+S    +CP+C  K      LI +  L N ++ +K
Sbjct:    3 VHYKFKSTLNFDTITFDGLHISVGDLKREIVQQKRLGKIIDFDLQITNAQSKEEYK-DDGFLIPKNTTLIISRIPIAHPTKKGWEPPAA--ENAFSAAPAKQDN----------FNMDLSKMQGTEEDKIQAMMMQSTVDYDPKTYHRIKGQSQ-VGEVPASYRCNKCKKSGHWIKNCPFVGGK-----DQQEVKRNTGIP-----RSFRDKPDAAENESADFVL------------------------PAVQN--QEIPEDLICGICRDIFVDAVMIPCCGSSFCDDCVRTSLLESEDS----ECPDCKEKNCSPGSLIPNRFLRNSVNAFK 281
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Fly
Match: snama (gene:FBgn0086129 transcript:FBtr0072249)

HSP 1 Score: 112.079 bits (279), Expect = 4.039e-25
Identity = 93/333 (27.93%), Postives = 150/333 (45.05%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELT-DAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSM--TEEQKVDTVIESAATNY------RIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKFKS LN   I F+G +ISV +L  + +++K      +  + + +  SKEE    +  LIP  + +II R+P+   +K       A  EN     P K  N           N++ S M  TEE K+  ++  +  +Y      RI G+    G  P++Y CNKC   GHWI NCP +  K     D ++VKR +GIP         + P++       +V+                        P V+    EIPE+++C +C ++        CC +++C +C+   L + E+S    +CP+C  K      LI +  L N ++ +K
Sbjct:    3 VHYKFKSTLNFDTITFDGLHISVGDLKREIVQQKRLGKIIDFDLQITNAQSKEEYK-DDGFLIPKNTTLIISRIPIAHPTKKGWEPPAA--ENAFSAAPAKQDN----------FNMDLSKMQGTEEDKIQAMMMQSTVDYDPKTYHRIKGQSQ-VGEVPASYRCNKCKKSGHWIKNCPFVGGK-----DQQEVKRNTGIPRSF-----RDKPDAAENESADFVL------------------------PAVQN--QEIPEDLICGICRDIFVDAVMIPCCGSSFCDDCVRTSLLESEDS----ECPDCKEKNCSPGSLIPNRFLRNSVNAFK 281
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Zebrafish
Match: rbbp6 (retinoblastoma binding protein 6 [Source:ZFIN;Acc:ZDB-GENE-040930-5])

HSP 1 Score: 131.724 bits (330), Expect = 4.469e-31
Identity = 101/333 (30.33%), Postives = 167/333 (50.15%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKI--ANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYR-IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGK---LIDSRQVKRPSGIPVCGLVEVDE-NTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +I++ +L   I  R+K   + C+L +   +  +KEE    E  LIP  S+VII+R+P+      +K   I  + P   SK     +++      + K  NL  ++ +EE K+  ++  +  +Y  I   +   G PP  YTC +C   GH+I NCP     NG+       +++K+ +GIP   +VEVD+ N     LT  G Y +   + +A   GKK+K PF + +N     + ++ +P+ ++C +C +L+T      CC N+YC +CI   L + E     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHITLSDLKRQIMGREKLKAADCDLQIT--NAQTKEEYTDDEA-LIPKNSSVIIRRIPIGGLKSTSKTYVIDRSEPSGSSKA---IDSSSISLALLSKTANLAETNASEEDKIKAMMSQSNHDYDPIHYAKKLVGPPPPNYTCFRCGKTGHYIRNCP----TNGQDRSFEAPQRIKKSTGIPRSFMVEVDDPNRKGVMLTNSGIYAIPTIDAEAYAIGKKEKPPF-LPQNQSSSSEEEDPVPDELLCLICKDLMTDAVVIPCCGNSYCDDCIRTCLLESEE----HVCPTCKQSDVSPDALIANKFLRQAVNNFK 321
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Zebrafish
Match: rbbp6 (retinoblastoma binding protein 6 [Source:ZFIN;Acc:ZDB-GENE-040930-5])

HSP 1 Score: 131.724 bits (330), Expect = 4.686e-31
Identity = 101/333 (30.33%), Postives = 167/333 (50.15%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKI--ANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYR-IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGK---LIDSRQVKRPSGIPVCGLVEVDE-NTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +I++ +L   I  R+K   + C+L +   +  +KEE    E  LIP  S+VII+R+P+      +K   I  + P   SK     +++      + K  NL  ++ +EE K+  ++  +  +Y  I   +   G PP  YTC +C   GH+I NCP     NG+       +++K+ +GIP   +VEVD+ N     LT  G Y +   + +A   GKK+K PF + +N     + ++ +P+ ++C +C +L+T      CC N+YC +CI   L + E     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHITLSDLKRQIMGREKLKAADCDLQIT--NAQTKEEYTDDEA-LIPKNSSVIIRRIPIGGLKSTSKTYVIDRSEPSGSSKA---IDSSSISLALLSKTANLAETNASEEDKIKAMMSQSNHDYDPIHYAKKLVGPPPPNYTCFRCGKTGHYIRNCP----TNGQDRSFEAPQRIKKSTGIPRSFMVEVDDPNRKGVMLTNSGIYAIPTIDAEAYAIGKKEKPPF-LPQNQSSSSEEEDPVPDELLCLICKDLMTDAVVIPCCGNSYCDDCIRTCLLESEE----HVCPTCKQSDVSPDALIANKFLRQAVNNFK 321
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Zebrafish
Match: zgc:174353 (zgc:174353 [Source:ZFIN;Acc:ZDB-GENE-071004-121])

HSP 1 Score: 94.7449 bits (234), Expect = 5.058e-21
Identity = 72/245 (29.39%), Postives = 115/245 (46.94%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNK--IKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVI-ESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDS-RQVKRPSGIPVCGLVEVDE-NTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENP 759
            V+Y+F+S L    + FEG NI+V EL   I ++     C L +        +E    ++ LIP  ++VII+R+P       N+  +   A P   +K     +++      + K  NL  +  +EE K+  V+ +S+   Y         G  P  Y C  C IPGH I +C   P K G    S ++++R +GIP   L+EVD+ N     +   G+YV+ I + +A    KK +  FS +  P
Sbjct:    4 VHYRFQSRLTYDSLQFEGLNITVGELKRQIMRRERLKFCQLKISKAQT---DEEYTDDDALIPKNTSVIIRRVPAAGLKSSNRRFVGHQAGPS--AKSSQTGDSSLLSLEQLLKTENLAEAKASEEDKLKAVMYQSSLCYYSSSEAMTLLGLLPPNYVCFHCGIPGHHIRHC---PSKGGSSSASQKRIRRSTGIPRSFLLEVDDPNRKGVMMDGSGKYVIPIIDAEAYAAEKKKRPSFSCQTKP 240
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Zebrafish
Match: zgc:174353 (zgc:174353 [Source:ZFIN;Acc:ZDB-GENE-071004-121])

HSP 1 Score: 94.7449 bits (234), Expect = 5.058e-21
Identity = 72/245 (29.39%), Postives = 115/245 (46.94%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNK--IKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVI-ESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDS-RQVKRPSGIPVCGLVEVDE-NTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENP 759
            V+Y+F+S L    + FEG NI+V EL   I ++     C L +        +E    ++ LIP  ++VII+R+P       N+  +   A P   +K     +++      + K  NL  +  +EE K+  V+ +S+   Y         G  P  Y C  C IPGH I +C   P K G    S ++++R +GIP   L+EVD+ N     +   G+YV+ I + +A    KK +  FS +  P
Sbjct:    4 VHYRFQSRLTYDSLQFEGLNITVGELKRQIMRRERLKFCQLKISKAQT---DEEYTDDDALIPKNTSVIIRRVPAAGLKSSNRRFVGHQAGPS--AKSSQTGDSSLLSLEQLLKTENLAEAKASEEDKLKAVMYQSSLCYYSSSEAMTLLGLLPPNYVCFHCGIPGHHIRHC---PSKGGSSSASQKRIRRSTGIPRSFLLEVDDPNRKGVMMDGSGKYVIPIIDAEAYAAEKKKRPSFSCQTKP 240
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Zebrafish
Match: zgc:174353 (zgc:174353 [Source:ZFIN;Acc:ZDB-GENE-071004-121])

HSP 1 Score: 94.7449 bits (234), Expect = 5.058e-21
Identity = 72/245 (29.39%), Postives = 115/245 (46.94%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNK--IKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVI-ESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDS-RQVKRPSGIPVCGLVEVDE-NTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENP 759
            V+Y+F+S L    + FEG NI+V EL   I ++     C L +        +E    ++ LIP  ++VII+R+P       N+  +   A P   +K     +++      + K  NL  +  +EE K+  V+ +S+   Y         G  P  Y C  C IPGH I +C   P K G    S ++++R +GIP   L+EVD+ N     +   G+YV+ I + +A    KK +  FS +  P
Sbjct:    4 VHYRFQSRLTYDSLQFEGLNITVGELKRQIMRRERLKFCQLKISKAQT---DEEYTDDDALIPKNTSVIIRRVPAAGLKSSNRRFVGHQAGPS--AKSSQTGDSSLLSLEQLLKTENLAEAKASEEDKLKAVMYQSSLCYYSSSEAMTLLGLLPPNYVCFHCGIPGHHIRHC---PSKGGSSSASQKRIRRSTGIPRSFLLEVDDPNRKGVMMDGSGKYVIPIIDAEAYAAEKKKRPSFSCQTKP 240
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Xenopus
Match: rbbp6 (pep primary_assembly:Xenopus_tropicalis_v9.1:9:14211598:14224196:1 gene:ENSXETG00000006787.1 transcript:ENSXETT00000020271.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rbbp6)

HSP 1 Score: 115.546 bits (288), Expect = 8.575e-26
Identity = 68/212 (32.08%), Postives = 111/212 (52.36%), Query Frame = 1 
Query:  382 NLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN + +   ++K+ +GIP   +VEV D N   + LT  G+Y +   +  A   GKK+K PF + E P    + ++ IP+ ++C +C ++++      CC N+YC  CI   L + E+    H CP C       D LI +  L   ++ +K
Sbjct:   27 NLVEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCLKPGHYIKNCPTNGDKNFESVP--RIKKSTGIPRSFMVEVEDPNMKGAMLTNTGKYAIPTIDAVAYAIGKKEKPPF-LPEEPASSSEDEDPIPDELLCLICKDMMSDAVVIPCCGNSYCDECIRTALLESED----HICPTCHQPDVSPDALIANKFLRQAVNNFK 231
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Xenopus
Match: rbbp6 (pep primary_assembly:Xenopus_tropicalis_v9.1:9:14199245:14224801:1 gene:ENSXETG00000006787.1 transcript:ENSXETT00000020324.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rbbp6)

HSP 1 Score: 115.161 bits (287), Expect = 1.157e-25
Identity = 69/217 (31.80%), Postives = 113/217 (52.07%), Query Frame = 1 
Query:  367 IFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN + +   ++K+ +GIP   +VEV D N   + LT  G+Y +   +  A   GKK+K PF + E P    + ++ IP+ ++C +C ++++      CC N+YC  CI   L + E+    H CP C       D LI +  L   ++ +K
Sbjct:   51 LTKTANLVEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCLKPGHYIKNCPTNGDKNFESVP--RIKKSTGIPRSFMVEVEDPNMKGAMLTNTGKYAIPTIDAVAYAIGKKEKPPF-LPEEPASSSEDEDPIPDELLCLICKDMMSDAVVIPCCGNSYCDECIRTALLESED----HICPTCHQPDVSPDALIANKFLRQAVNNFK 260
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Xenopus
Match: rbbp6 (pep primary_assembly:Xenopus_tropicalis_v9.1:9:14199245:14224801:1 gene:ENSXETG00000006787.1 transcript:ENSXETT00000020309.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rbbp6)

HSP 1 Score: 114.005 bits (284), Expect = 2.855e-25
Identity = 68/213 (31.92%), Postives = 111/213 (52.11%), Query Frame = 1 
Query:  379 INLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
             NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN + +   ++K+ +GIP   +VEV D N   + LT  G+Y +   +  A   GKK+K PF + E P    + ++ IP+ ++C +C ++++      CC N+YC  CI   L + E+    H CP C       D LI +  L   ++ +K
Sbjct:   41 ANLVEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCLKPGHYIKNCPTNGDKNFESVP--RIKKSTGIPRSFMVEVEDPNMKGAMLTNTGKYAIPTIDAVAYAIGKKEKPPF-LPEEPASSSEDEDPIPDELLCLICKDMMSDAVVIPCCGNSYCDECIRTALLESED----HICPTCHQPDVSPDALIANKFLRQAVNNFK 246
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Xenopus
Match: rbbp6 (pep primary_assembly:Xenopus_tropicalis_v9.1:9:14199607:14224801:1 gene:ENSXETG00000006787.1 transcript:ENSXETT00000020295.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rbbp6)

HSP 1 Score: 107.842 bits (268), Expect = 1.880e-23
Identity = 62/182 (34.07%), Postives = 97/182 (53.30%), Query Frame = 1 
Query:  469 RNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            + P G PP +YTC +C  PGH+I NCP   DKN + +   ++K+ +GIP   +VEV D N   + LT  G+Y +   +  A   GKK+K PF + E P    + ++ IP+ ++C +C ++++      CC N+YC  CI   L + E+    H CP C       D LI +  L   ++ +K
Sbjct:   17 KKPLGPPPPSYTCFRCLKPGHYIKNCPTNGDKNFESVP--RIKKSTGIPRSFMVEVEDPNMKGAMLTNTGKYAIPTIDAVAYAIGKKEKPPF-LPEEPASSSEDEDPIPDELLCLICKDMMSDAVVIPCCGNSYCDECIRTALLESED----HICPTCHQPDVSPDALIANKFLRQAVNNFK 191
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Mouse
Match: Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase [Source:MGI Symbol;Acc:MGI:894835])

HSP 1 Score: 141.354 bits (355), Expect = 4.359e-34
Identity = 99/329 (30.09%), Postives = 164/329 (49.85%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPEN-FSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG--KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  +      +  + + +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E          +A+   SL  + K  NL  ++ +EE K+  ++  +   Y  +   K+   G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 324
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Mouse
Match: Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase [Source:MGI Symbol;Acc:MGI:894835])

HSP 1 Score: 140.969 bits (354), Expect = 5.342e-34
Identity = 99/329 (30.09%), Postives = 164/329 (49.85%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPEN-FSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG--KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  +      +  + + +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E          +A+   SL  + K  NL  ++ +EE K+  ++  +   Y  +   K+   G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 324
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Mouse
Match: Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase [Source:MGI Symbol;Acc:MGI:894835])

HSP 1 Score: 125.176 bits (313), Expect = 5.583e-29
Identity = 100/367 (27.25%), Postives = 165/367 (44.96%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPEN-FSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG--KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKN--------------------------------------RDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  +      +  + + +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E          +A+   SL  + K  NL  ++ +EE K+  ++  +   Y  +   K+   G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   +                                      R+A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAGRLLFHKLGTMGHKQIDTYLWNRGDVYGAAATQITHLREAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 362
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. UniProt/SwissProt
Match: sp|Q7Z6E9|RBBP6_HUMAN (E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 2.410e-34
Identity = 102/330 (30.91%), Postives = 169/330 (51.21%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI--RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPE-NFSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  R+K   + C+L +   +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E   +      +++   SL  + K  NL  ++ +EE K+  ++  +   Y  +   + P G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQIT--NAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 323
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. UniProt/SwissProt
Match: sp|P97868|RBBP6_MOUSE (E3 ubiquitin-protein ligase RBBP6 OS=Mus musculus OX=10090 GN=Rbbp6 PE=1 SV=5)

HSP 1 Score: 140.969 bits (354), Expect = 3.737e-33
Identity = 99/329 (30.09%), Postives = 164/329 (49.85%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPEN-FSKVDPYKNANEKESL-NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVG--KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            V+YKF S+LN   + F+G +IS+ +L   I  +      +  + + +  +KEE    +N LIP  S+VI++R+P+      +K   I+  E          +A+   SL  + K  NL  ++ +EE K+  ++  +   Y  +   K+   G PP +YTC +C  PGH+I NCP   DKN       ++K+ +GIP   ++EV D N   + LT  G+Y +   + +A   GKK+K PF + E P    +  + IP+ ++C +C +++T      CC N+YC  CI   L + +     H CP C       D LI +  L   ++ +K
Sbjct:    4 VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEE-YTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKN--FESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPF-LPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDE----HTCPTCHQNDVSPDALIANKFLRQAVNNFK 324
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. UniProt/SwissProt
Match: sp|B9DFV2|PQT3L_ARATH (E3 ubiquitin ligase PQT3-like OS=Arabidopsis thaliana OX=3702 GN=At5g47430 PE=1 SV=1)

HSP 1 Score: 112.079 bits (279), Expect = 3.479e-24
Identity = 106/375 (28.27%), Postives = 163/375 (43.47%), Query Frame = 1 
Query:   40 VYYKFKSELNQQQIPFEGSNISVKELTDAI-RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLP-------LTDQSK--HNKIKKI-ANPENFSKVDP-----------------YKNANEKESLNIFKRINLNSSS--MTEEQKVDTVIESAATNYR------IVGKRNPYG-----------------TPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLIT-APTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKL-DELIDDSELENLI 999
            +YYKFKS  +   I  +G  ISV  L D I   KH  +  +L + + +  + EE    E  LIP  ++V+I+R+P       +T Q     NK++ + A   NF   DP                 Y   + +++ +I  R +L ++   + EE K+  +I++ A +++        G    YG                 TPP  Y C++CNIPGH+I +CP   D N    D ++VK P+GIP   L+   +    SY  P G   V   N DA  K           E  P   +   E+P  + C LC  ++  A   + CC  ++C  CI DH+     S  M  C    G+ D L D+L+ +  L + I
Sbjct:    3 IYYKFKSARDYDTIAMDGPFISVGILKDKIFETKHLGTGKDLDIVVSNAQTNEE-YLDEAMLIPKNTSVLIRRVPGRPRITVITTQEPRIQNKVEDVQAETTNFPVADPSAAEFPEDEYDEFGTDLYSIPDTQDAQHIIPRPHLATADDKVDEESKIQALIDTPALDWQQRQGQDTFGAGRGYGRGMPGRMNGRGFGMERKTPPPGYVCHRCNIPGHFIQHCPTNGDPN---YDVKRVKPPTGIPKSMLMATPD---GSYSLPSGAVAVLKPNEDAFEKEM---------EGLPSTTRSVGELPPELKCPLCKEVMKDAALTSKCCYKSFCDKCIRDHII----SKSMCVC----GRSDVLADDLLPNKTLRDTI 353
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. UniProt/SwissProt
Match: sp|P35728|MPE1_YEAST (Protein MPE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MPE1 PE=1 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 3.903e-21
Identity = 87/364 (23.90%), Postives = 160/364 (43.96%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAI---RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLP-LTDQSKHNKIKKIANPENFSKVDPYKNANEK--ESLNIFKRINLNSSSMTEEQKVDTVIE-------------SAATNYRIVGKRNP------YGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGL--VEVDENTPNS--------YLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPK-NEIPENMVCRLCSNLITAPTKTA-CCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIW 1008
            MS  ++Y+FKS+ N  +I F+G+ ++V +L   I    K    +   L +Y  D    EE    +  +IP  ++VI+KR P +   S H+++K             Y     +  +          N S  TEE+++ ++               SAAT      + N        G PP  Y C +C    HWI NCP   D N    + ++++R +GIP   L  +E+D  T            +T +G++VV ++++ +    ++ +    I+ +  + ++    ++P+++ C L   L+  P KT+ CCN  + +  + + L + +       CPNC  +   LD L+ D + E  +  +
Sbjct:    1 MSSTIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDT---EEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTNSDPN---FEGKRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVESD-----FVCPNCETRDILLDSLVPDQDKEKEVETF 353
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. UniProt/SwissProt
Match: sp|O94264|YORF_SCHPO (Uncharacterized RING finger protein P8B7.15c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBP8B7.15c PE=4 SV=1)

HSP 1 Score: 92.4337 bits (228), Expect = 2.137e-18
Identity = 91/357 (25.49%), Postives = 148/357 (41.46%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGS-NISVKELT-DAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIAN-----------------------PENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQ-KVDTVIESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCP--GIPDKNGKLIDSRQVKRPSGIPVCGLVEVDE----NTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIH 1002
            MS ++YYKFKS+ +  +I F+G+  +SV ++  + I +K   +  +  + + +  S EE    +  +IP  ++VI++R+P     K    + ++                        P    + +  K+ +  E   I +   ++S    E Q K+ +       N R +    P   PP  Y C +C   GHWI  CP    P+ +GK     +VKR +GIP   L  V+     +  N  +  +G YVV     D         R  ++  N     QP N    ++ C LC  L     +T CC+  +C  CI   L D +      +CPNC  K   LD L  D + +  I 
Sbjct:    1 MSGVIYYKFKSQKDPSRITFDGTIGMSVFDVKREIIMQKKLGNGLDFDLLLYNANSNEEYD-DDTFIIPRSTSVIVRRVPAQKSGKGTAARYVSGAPKTTGARSDSVKRPVPMLQKKAPITSGESNINKSPSSSEDAAIQQMFQVSSDQWRETQDKMASATPIYKPNQRRIAASVPDKPPPPGYICYRCGQKGHWIQACPTNADPNYDGKP----RVKRTTGIPRSFLKNVERPAEGDAANIMINAEGDYVV--VQPDVASWETYQSRKAALTANDVYKMQPPN---ISLACTLCKKLARNACRTPCCDKLFCEECIQTALLDSD-----FECPNCHRKDVLLDTLNPDYQKQREIE 342
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. TrEMBL
Match: A0A0F7GWV9 (Retinoblastoma binding protein 6 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 278.87 bits (712), Expect = 2.132e-78
Identity = 163/388 (42.01%), Postives = 227/388 (58.51%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFK-RINLNSSSMTEEQKVDTVIESAATNYR---IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKN-EIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWKISKIPK------ITELT-----KTPINSVKL---EAKLPSAMTDDDLLNEIFTTE 1134
            MS  VY+KFK+ + Q  IPF+GS ISVK+L  AIR        +  + + D   KE     E++LIP FS++I++RLP  +       KKIANPE+ ++ DPYK  N    +N +   INL  S++ +++K+D + +  +  Y     + K  PYG PP++Y CNKC+  GHWI+ CPG+ DK+G+L+D + VKRP+GIP   L+EV   TP +YLT +G+Y+V IK+ +A   GKK+KRPFSIEENPP V  PK+ E P  + C LC  L+  PT   CC++ YC  CITD+L+DPE      +CPNC   I+    LI+   L  LI  WK + + K      +T L      KT +N V     + K  SA TD D L+    TE
Sbjct:    8 MSSAVYFKFKASIKQYTIPFDGSAISVKDLRSAIRLSCGLKSTDFELQILDKQGKE--YSKEDDLIPKFSDLIVRRLPKANDMPR---KKIANPEDMTRRDPYKAINSLPKINPYSNSINLAKSNIPDDEKIDIMAKRCSEEYSEKNFLVKSKPYGIPPASYVCNKCHQGGHWIHECPGLRDKDGRLLDFKSVKRPTGIPQDFLLEVSPGTPGAYLTKEGKYMVPIKDAEAYAMGKKEKRPFSIEENPPYV--PKDQEFPSKIKCSLCCKLLENPTCAPCCSSVYCEKCITDYLYDPE-VNGSRKCPNCQSLIEHHTSLIEHELLRQLIQCWKANLLTKEIVDSCVTTLNHSSNKKTELNEVNCASPDMKYESANTDVDSLSNKAETE 387
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. TrEMBL
Match: C7TZR6 (Retinoblastoma-binding protein 6 (Fragment) OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 251.136 bits (640), Expect = 2.791e-72
Identity = 130/333 (39.04%), Postives = 202/333 (60.66%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLP-LTDQSKHNKIKKIANPENFSKVDPYKNAN-EKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYR---IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKI-DKLDELIDDSELENLIHIW 1008
            MS +VY+KFK+ +    + F+GS+ISVK+L +AIR K      +  + ++D   K      ++ELIP +S+++++R+P L  +S+    KK   P+  +  +  +      E+ +  K INL  S ++EE+K+  ++E ++  Y       +  PYG PP+ Y C+KCN PGHWI+NCPG+ DK GK++D++ VKRP+GIP   L+EV   TP +YL   G+Y+V IK+ +A  +GKKDKRPFS+EENPP V Q +N  P+ ++C LCS L +     +CC  TYC  CI  H+FD +     H+CPNC   + D    + +++ + +LI  W
Sbjct:    1 MSSIVYFKFKANVKTDSVSFDGSSISVKDLKNAIRTKCCLYSTDFDLKLEDTTGKTYS--KDDELIPKYSSIVVRRVPRLVAESQK---KKQLGPDELTWRELQRGQTVTSEASHGSKPINLADSDLSEEEKIKLMMERSSETYSETNFTVRAKPYGVPPAAYICHKCNQPGHWIHNCPGVRDKTGKVMDAKLVKRPTGIPQDFLLEVAAGTPGAYLGKSGKYMVPIKDAEAYAQGKKDKRPFSVEENPPYVPQERNP-PKQLICPLCSKLFSDAVLVSCCGTTYCNECIMGHVFDSQ-VLGSHKCPNCDAVLTDHESSVFENALVRSLIRDW 326
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. TrEMBL
Match: A0A448WKZ9 (Uncharacterized protein (Fragment) OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS7804 PE=4 SV=1)

HSP 1 Score: 258.455 bits (659), Expect = 1.596e-71
Identity = 133/360 (36.94%), Postives = 219/360 (60.83%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKD----IISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANE-KESLNIFKRINLNSSSMTEEQKVDTVIESAATNY-----RIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKI-DKLDELIDDSELENLIHIWKISKIPKITELTKTPINSVKLE 1074
            M+ LVY+KFK+ + Q  IPF+GS ISVK+L  AIR K      +L + ++D    I SK++      ELIP +++++++R+P        +  K+A   + +K + +K++    ++++I K ++L  S +TEE+K+  +IE ++  Y       + K  P+G PP  Y C+KCN PGHWI+NCPG+ DK+GKL+D R +KRP+GIP   L+EVD +TP +YL   G+Y+V IK+ +A  +GKKDKRPFS+EENPP +       P+++ C LC+++        CC  TYC +CI  + FD +    + +CPNC   + D    + +++ + ++I  W  S + +  EL ++P + +K++
Sbjct:    6 MASLVYFKFKANVKQDSIPFDGSAISVKDLKTAIRTKCCLHSADLDLKLEDKNGKIYSKDD------ELIPKYTSILVRRVPRMGNDPQRR--KLALSGDAAKKELHKSSGGPSDAVHIPKNVSLADSDLTEEEKIRVMIERSSDAYEKWYAHSLTKAKPFGIPPPAYICHKCNQPGHWIHNCPGVKDKSGKLMDPRNIKRPTGIPQDFLLEVDADTPGAYLGKTGKYMVPIKDAEAFAQGKKDKRPFSVEENPPYIPPTNRRPPKHLTCPLCTDVFKNAVLVGCCGTTYCNDCIMGYAFDSQIKG-LQKCPNCSAPLTDHESSVFENATVRSMIIEWHNSTLAENNELARSPSHLLKVD 356
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. TrEMBL
Match: Q5C0C6 (SJCHGC03553 protein (Fragment) OS=Schistosoma japonicum OX=6182 PE=2 SV=2)

HSP 1 Score: 243.817 bits (621), Expect = 1.777e-70
Identity = 127/328 (38.72%), Postives = 198/328 (60.37%), Query Frame = 1 
Query:   43 YYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLP-LTDQSKHNKIKKIANPENFSKVDPYKNAN-EKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYR---IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKI-DKLDELIDDSELENLIHIW 1008
            Y+KFK+ +    + F+GS+ISVK+L +AIR K      +  + ++D   K      ++ELIP +S+++++R+P L  +S+    KK   P+  +  +  +      E+ +  K INL  S ++EE+K+  ++E ++  Y       +  PYG PP+ Y C+KCN PGHWI+NCPG+ DK GK++D++ VKRP+GIP   L+EV   TP +YL   G+Y+V IK+ +A  +GKKDKRPFS+EENPP V Q +N  P+ ++C LCS L +     +CC  TYC  CI  H+FD +     H+CPNC   + D    + +++ + +LI  W
Sbjct:    3 YWKFKANVKTDSVSFDGSSISVKDLKNAIRTKCCLYSTDFDLKLEDTTGKTYS--KDDELIPKYSSIVVRRVPRLVAESQK---KKQLGPDELTWRELQRGQTVTSEASHGSKPINLADSDLSEEEKIKLMMERSSETYSETNFTVRAKPYGVPPAAYICHKCNQPGHWIHNCPGVRDKTGKVMDAKLVKRPTGIPQDFLLEVAAGTPGAYLGKSGKYMVPIKDAEAYAQGKKDKRPFSVEENPPYVPQERNP-PKQLICPLCSKLFSDAVLVSCCGTTYCNECIMGHVFDSQ-VLGSHKCPNCDAVLTDHESSVFENALVRSLIRDW 323
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. TrEMBL
Match: A0A5J4N706 (E3 ubiquitin-protein ligase RBBP6 OS=Paragonimus westermani OX=34504 GN=DEA37_0013786 PE=4 SV=1)

HSP 1 Score: 243.047 bits (619), Expect = 1.965e-70
Identity = 129/338 (38.17%), Postives = 201/338 (59.47%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLP-LTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNI----F-KRINLNSSSMTEEQKVDTVIESAATNYR---IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEI-PENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKI-DKLDELIDDSELENLIHIW 1008
            MS +VY+KFK+ +    + F+GS ISVK+L  AIR K      +  + ++D   K      ++ELIP +++++++R+P LT +++    +KI   E+     P+K  N++  +N+    F K +NL  S + EE+K+  ++E ++  Y       K  PYG PP+ Y C+KC +PGHWI+NCPG+ DK+GK++D + VKRP+GIP   L+EV+  TP +YL   G+Y+V IK+ +A  +GKKDKRPFS+EENPP    P   I P+  +C LC  L       +CC  TYC  CI  H+FD +     H+CPNC   + D    + +++ + ++I  W
Sbjct:    1 MSSIVYFKFKANVKTDTVQFDGSAISVKDLKSAIRTKCCLYSTDFDLKLEDTNGKAYT--KDDELIPKYTSIVVRRVPKLTSETQK---RKITTSEDL----PWKE-NQRAQINMNDAGFQKHVNLADSDLPEEEKIKIMMERSSETYSEKNFTVKAKPYGVPPAAYICHKCGLPGHWIHNCPGVRDKSGKMMDIKSVKRPTGIPQDFLLEVEAGTPGAYLGKSGKYMVPIKDAEAYAQGKKDKRPFSVEENPPYF--PSERIPPKQFICPLCGGLFREAVLVSCCGTTYCNECIMGHVFDAQ-ILGSHKCPNCEAILNDHESSVFENALVRSMIRDW 325
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Cavefish
Match: rbbp6 (retinoblastoma binding protein 6 [Source:ZFIN;Acc:ZDB-GENE-040930-5])

HSP 1 Score: 95.5153 bits (236), Expect = 8.778e-20
Identity = 60/195 (30.77%), Postives = 100/195 (51.28%), Query Frame = 1 
Query:  364 NIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGK---LIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNC 939
             + K  NL  ++ +EE K+  ++  +   Y  +  +   G PP  YTC +C   GH+I NCP     NG+       ++VKR +GIP   ++EVD++   + LT  G Y +   + +A   GKK+K PF  +E      + ++ +P+ ++C +C +L+T      CC N+YC + I  +L + E     H CP C
Sbjct:   23 QLSKTANLAEANASEEDKIRAMMSQSNHEYDPIFTKK-LGPPPPNYTCFRCGKNGHYIRNCP----TNGQDKSFEAPQRVKRSTGIPRSFMMEVDQSMKGAMLTNTGTYAIPTID-EAYALGKKEKPPFLPKEQ-SSSSEDEDPVPDELLCLICKDLMTDAVVIPCCGNSYC-DEIRSNLLESEE----HTCPTC 205
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010453.1 (pep scaffold:Pmarinus_7.0:GL483937:7299:12919:1 gene:ENSPMAG00000009464.1 transcript:ENSPMAT00000010453.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 112.849 bits (281), Expect = 2.146e-28
Identity = 64/193 (33.16%), Postives = 104/193 (53.89%), Query Frame = 1 
Query:  367 IFKRINLNSSSMTEEQKVDTVIESAATNYRIVGK-RNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEV-DENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNC 939
            + K  N+  ++ +EE K+  V+  +  +Y  V   +   G PPS+YTC +C  PGH+I NCP   DK+ + +   ++K+ +GIP+  + EV D +   + LT  G+Y V   +  A   GKK+K PF  E++     +  + IP+ ++C LC +L+       CC N+YC +C+   L D E+    H CP C
Sbjct:   19 LIKTANIAEANASEEDKIKAVMNQSGQDYDPVNYVKKSQGPPPSSYTCYRCLKPGHYIKNCPLNADKSYEAL--PRLKKSTGIPLSFMTEVNDPSIKGAMLTNTGKYAVPTIDAQAYAVGKKEKPPFVTEQSSSSSDE--DPIPDELLCLLCKDLMVDAVVIPCCGNSYCDDCVRTVLLDSED----HTCPTC 203
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Yeast
Match: MPE1 (Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; both the zinc knuckle and RING finger are required for pre-mRNA binding; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000001542])

HSP 1 Score: 100.523 bits (249), Expect = 5.620e-23
Identity = 87/364 (23.90%), Postives = 160/364 (43.96%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAI---RKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLP-LTDQSKHNKIKKIANPENFSKVDPYKNANEK--ESLNIFKRINLNSSSMTEEQKVDTVIE-------------SAATNYRIVGKRNP------YGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGL--VEVDENTPNS--------YLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPK-NEIPENMVCRLCSNLITAPTKTA-CCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIW 1008
            MS  ++Y+FKS+ N  +I F+G+ ++V +L   I    K    +   L +Y  D    EE    +  +IP  ++VI+KR P +   S H+++K             Y     +  +          N S  TEE+++ ++               SAAT      + N        G PP  Y C +C    HWI NCP   D N    + ++++R +GIP   L  +E+D  T            +T +G++VV ++++ +    ++ +    I+ +  + ++    ++P+++ C L   L+  P KT+ CCN  + +  + + L + +       CPNC  +   LD L+ D + E  +  +
Sbjct:    1 MSSTIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDT---EEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTNSDPN---FEGKRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVESD-----FVCPNCETRDILLDSLVPDQDKEKEVETF 353
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Medaka
Match: ENSORLT00000010826.2 (E3 ubiquitin-protein ligase RBBP6 [Source:NCBI gene;Acc:101160962])

HSP 1 Score: 106.301 bits (264), Expect = 4.374e-23
Identity = 77/268 (28.73%), Postives = 126/268 (47.01%), Query Frame = 1 
Query:  223 IPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIF---KRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDS-RQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            IP  ++VI++R PL       +   I +  + S V   +  +   SL++    K  NL  ++ +EE K+  ++  +  +Y      +   G PP+ YTC +C   GH+I  CP +P    K  D  + VK   GIP   +V+ D  T  + LT  G Y +   + +A  +GKK++ PF   E     +   + IP+ ++C +C++L+T      CC N+YC  CI   L D E     H C +C       D LI +  L   ++ +K
Sbjct:   27 IPKHASVIVRRTPLGGVKPAGRTF-IVDRSDTSVVGSSRPTDSSPSLSLAQLAKTANLVDANASEEDKIKAMMTQSNHDYDPANYSKKAIGPPPAHYTCFRCGKAGHYIRQCP-LPVVQDKSADGPKPVKISKGIPQSFMVKADPGTKGAMLTSTGEYAIPAIDAEAYAQGKKERPPFVPHEQS-SSEDDTDPIPDELLCPICNDLMTDAVVIPCCGNSYCDECIRTALLDSEE----HICSSCNQSDVSPDNLIANKFLRQAVNNFK 287
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Medaka
Match: ENSORLT00000042274.1 (E3 ubiquitin-protein ligase RBBP6 [Source:NCBI gene;Acc:101160962])

HSP 1 Score: 105.916 bits (263), Expect = 4.788e-23
Identity = 77/268 (28.73%), Postives = 126/268 (47.01%), Query Frame = 1 
Query:  223 IPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIF---KRINLNSSSMTEEQKVDTVIESAATNYRIVG-KRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDS-RQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWK 1011
            IP  ++VI++R PL       +   I +  + S V   +  +   SL++    K  NL  ++ +EE K+  ++  +  +Y      +   G PP+ YTC +C   GH+I  CP +P    K  D  + VK   GIP   +V+ D  T  + LT  G Y +   + +A  +GKK++ PF   E     +   + IP+ ++C +C++L+T      CC N+YC  CI   L D E     H C +C       D LI +  L   ++ +K
Sbjct:   27 IPKHASVIVRRTPLGGVKPAGRTF-IVDRSDTSVVGSSRPTDSSPSLSLAQLAKTANLVDANASEEDKIKAMMTQSNHDYDPANYSKKAIGPPPAHYTCFRCGKAGHYIRQCP-LPVVQDKSADGPKPVKISKGIPQSFMVKADPGTKGAMLTSTGEYAIPAIDAEAYAQGKKERPPFVPHEQS-SSEDDTDPIPDELLCPICNDLMTDAVVIPCCGNSYCDECIRTALLDSEE----HICSSCNQSDVSPDNLIANKFLRQAVNNFK 287
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Medaka
Match: ENSORLT00000046531.1 (RB binding protein 6, ubiquitin ligase [Source:NCBI gene;Acc:101161731])

HSP 1 Score: 53.9138 bits (128), Expect = 5.602e-7
Identity = 32/112 (28.57%), Postives = 54/112 (48.21%), Query Frame = 1 
Query:  703 DALLKGKKDKRPFSIEENPPLVKQPKNE-----IPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWKISKI 1023
            +A   GKK++ PF  +      KQPK+E     +P+ ++C +C +L+       CC N+YC +CI   L D ++    H CP C       D L  +  L   ++ +K  ++
Sbjct:   57 EAYAIGKKERPPFLPQ------KQPKSESEDDPVPDELLCLICRDLLDDAVVIHCCRNSYCDDCIRTTLLDSDD----HVCPTCGQSSVSPDSLTANKFLRQAVNNFKKERV 158
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Planmine SMEST
Match: SMESG000023195.1 (SMESG000023195.1)

HSP 1 Score: 1147.5 bits (2967), Expect = 0.000e+0
Identity = 608/609 (99.84%), Postives = 608/609 (99.84%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWKISKIPKITELTKTPINSVKLEAKLPSAMTDDDLLNEIFTTENKENDHPTAADWEFASQPVSKSEHLSQDPNIRSTNPTGDQLLSDRATAEMIRKLASADCAEGIVELMKSNPKAIQLIQGLVNSLVPENTNNNHYKXXXXXXXXXXXXXXXNETEFRHQPIKHRDESRNSYRKSQKPTENRQFQNRYPTANRNVHPSREEQQRQNGXXXXXXXXXXXCQRRHDNHRQIDNQYRKRRASRSQSPIKINSQSLXXXXXXXXXXXXXXXXXXXTEKKSEYFPSD 1854
            MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWKISKIPKITELTKTPINSVKLEAKLPSAMTDDDLLNEIFTTENKENDHPTAADWEFASQPVSKSEHLSQDPNIRSTNPTGDQLLSDRATAEMIRKLASADCAEGIVELMKSNPKAIQLIQGLVNSLVPENTNNNHYKHRSRSRPSEPRHHRRNETEFRHQ IKHRDESRNSYRKSQKPTENRQFQNRYPTANRNVHPSREEQQRQNGSNSSPLSLSSSCQRRHDNHRQIDNQYRKRRASRSQSPIKINSQSLERNSNRRIKKSKKYKHERRTEKKSEYFPSD
Sbjct:    1 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWKISKIPKITELTKTPINSVKLEAKLPSAMTDDDLLNEIFTTENKENDHPTAADWEFASQPVSKSEHLSQDPNIRSTNPTGDQLLSDRATAEMIRKLASADCAEGIVELMKSNPKAIQLIQGLVNSLVPENTNNNHYKHRSRSRPSEPRHHRRNETEFRHQSIKHRDESRNSYRKSQKPTENRQFQNRYPTANRNVHPSREEQQRQNGSNSSPLSLSSSCQRRHDNHRQIDNQYRKRRASRSQSPIKINSQSLERNSNRRIKKSKKYKHERRTEKKSEYFPSD 609
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Planmine SMEST
Match: SMESG000068426.1 (SMESG000068426.1)

HSP 1 Score: 277.33 bits (708), Expect = 2.363e-81
Identity = 163/388 (42.01%), Postives = 227/388 (58.51%), Query Frame = 1 
Query:   28 MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMKDIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKVDPYKNANEKESLNIFK-RINLNSSSMTEEQKVDTVIESAATNYR---IVGKRNPYGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGLVEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQPKN-EIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDELIDDSELENLIHIWKISKIPK------ITELT-----KTPIN---SVKLEAKLPSAMTDDDLLNEIFTTE 1134
            MS  VY+KFK+ + Q  IPF+GS ISVK+L  AIR        +  + + D   KE     E++LIP FS++I++RLP  +       KKIANPE+ ++ DPYK  N    +N +   INL  S++ +++K+D + +  +  Y     + K  PYG PP++Y CNKC+  GHWI+ CPG+ DK+G+L+D + VKRP+GIP   L+EV   TP +YLT +G+Y+V IK+ +A   GKK+KRPFSIEENPP V  PK+ E P  + C LC  L+  PT   CC++ YC  CITD+L+DPE      +CPNC   I+    LI+   L  LI  WK + + K      +T L      KT +N   S   + K  SA TD D L+    TE
Sbjct:    1 MSSAVYFKFKASIKQYTIPFDGSAISVKDLRSAIRLSCGLKSTDFELQILDKQGKE--YSKEDDLIPKFSDLIVRRLPKANDMPR---KKIANPEDMTRRDPYKAINSLPKINPYSNSINLAKSNIPDDEKIDIMAKRCSEEYSEKNFLVKSKPYGIPPASYVCNKCHQGGHWIHECPGLRDKDGRLLDFKSVKRPTGIPQDFLLEVSPGTPGAYLTKEGKYMVPIKDAEAYAMGKKEKRPFSIEENPPYV--PKDQEFPSKIKCSLCCKLLENPTCAPCCSSVYCEKCITDYLYDPE-VNGSRKCPNCQSLIEHHTSLIEHELLRQLIQCWKANLLTKEIVDSCVTTLNHSSNKKTELNEDSSKSPDMKYESANTDVDSLSNKAETE 380
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Planmine SMEST
Match: SMESG000064788.1 (SMESG000064788.1)

HSP 1 Score: 59.3066 bits (142), Expect = 6.586e-9
Identity = 34/127 (26.77%), Postives = 67/127 (52.76%), Query Frame = 1 
Query:  763 LVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDE-LIDDSELEN-------LIHIWKISKIPKITELTKTPINSVKLEA--KLPSAMTDDDLL 1113
            +V++ +  IP+ + C LC+ L+    +  CC  +YC  CIT +LFDP+ S  + +CP+C   +   D  L+D+ ++ N       L+H+  + +I   T+++      + +++   +  +  DD LL
Sbjct:  124 IVEKIEQSIPDILKCCLCNQLMKDSMQIKCCKKSYCHECITGYLFDPDISGSL-ECPDCKSIVSIKDANLVDNMKIRNNPSTEEFLMHLENVQEIEITTDISSVQEEEIHVKSYENVECSQIDDLLL 249
[Close]
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Planmine SMEST
Match: SMESG000064788.1 (SMESG000064788.1)

HSP 1 Score: 55.8398 bits (133), Expect = 8.688e-8
Identity = 34/134 (25.37%), Postives = 67/134 (50.00%), Query Frame = 1 
Query:  763 LVKQPKNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQCPNCLGKIDKLDE-LIDDSEL--------------ENLIHIWKISKIPKITELTKTPINSVKLEA--KLPSAMTDDDLL 1113
            +V++ +  IP+ + C LC+ L+    +  CC  +YC  CIT +LFDP+ S  + +CP+C   +   D  L+D+ ++              E L+H+  + +I   T+++      + +++   +  +  DD LL
Sbjct:  125 IVEKIEQSIPDILKCCLCNQLMKDSMQIKCCKKSYCHECITGYLFDPDISGSL-ECPDCKSIVSIKDANLVDNMKIRRNVDTVEDNPSTEEFLMHLENVQEIEITTDISSVQEEEIHVKSYENVECSQIDDLLL 257
The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RBBP61.658e-3731.70RB binding protein 6, ubiquitin ligase [Source:HGN... [more]
RBBP61.357e-3530.91RB binding protein 6, ubiquitin ligase [Source:HGN... [more]
RBBP64.848e-3530.91RB binding protein 6, ubiquitin ligase [Source:HGN... [more]
RBBP65.018e-3530.91RB binding protein 6, ubiquitin ligase [Source:HGN... [more]
RBBP66.816e-3027.99RB binding protein 6, ubiquitin ligase [Source:HGN... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
rbpl-12.132e-3226.61Retinoblastoma Binding Protein Like [Source:UniPr... [more]
rbpl-11.348e-1428.19Retinoblastoma Binding Protein Like [Source:UniPr... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
snama6.099e-2627.93gene:FBgn0086129 transcript:FBtr0307174[more]
snama4.039e-2527.93gene:FBgn0086129 transcript:FBtr0072249[more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rbbp64.469e-3130.33retinoblastoma binding protein 6 [Source:ZFIN;Acc:... [more]
rbbp64.686e-3130.33retinoblastoma binding protein 6 [Source:ZFIN;Acc:... [more]
zgc:1743535.058e-2129.39zgc:174353 [Source:ZFIN;Acc:ZDB-GENE-071004-121][more]
zgc:1743535.058e-2129.39zgc:174353 [Source:ZFIN;Acc:ZDB-GENE-071004-121][more]
zgc:1743535.058e-2129.39zgc:174353 [Source:ZFIN;Acc:ZDB-GENE-071004-121][more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
rbbp68.575e-2632.08pep primary_assembly:Xenopus_tropicalis_v9.1:9:142... [more]
rbbp61.157e-2531.80pep primary_assembly:Xenopus_tropicalis_v9.1:9:141... [more]
rbbp62.855e-2531.92pep primary_assembly:Xenopus_tropicalis_v9.1:9:141... [more]
rbbp61.880e-2334.07pep primary_assembly:Xenopus_tropicalis_v9.1:9:141... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Rbbp64.359e-3430.09retinoblastoma binding protein 6, ubiquitin ligase... [more]
Rbbp65.342e-3430.09retinoblastoma binding protein 6, ubiquitin ligase... [more]
Rbbp65.583e-2927.25retinoblastoma binding protein 6, ubiquitin ligase... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q7Z6E9|RBBP6_HUMAN2.410e-3430.91E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens ... [more]
sp|P97868|RBBP6_MOUSE3.737e-3330.09E3 ubiquitin-protein ligase RBBP6 OS=Mus musculus ... [more]
sp|B9DFV2|PQT3L_ARATH3.479e-2428.27E3 ubiquitin ligase PQT3-like OS=Arabidopsis thali... [more]
sp|P35728|MPE1_YEAST3.903e-2123.90Protein MPE1 OS=Saccharomyces cerevisiae (strain A... [more]
sp|O94264|YORF_SCHPO2.137e-1825.49Uncharacterized RING finger protein P8B7.15c OS=Sc... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0F7GWV92.132e-7842.01Retinoblastoma binding protein 6 OS=Schmidtea medi... [more]
C7TZR62.791e-7239.04Retinoblastoma-binding protein 6 (Fragment) OS=Sch... [more]
A0A448WKZ91.596e-7136.94Uncharacterized protein (Fragment) OS=Protopolysto... [more]
Q5C0C61.777e-7038.72SJCHGC03553 protein (Fragment) OS=Schistosoma japo... [more]
A0A5J4N7061.965e-7038.17E3 ubiquitin-protein ligase RBBP6 OS=Paragonimus w... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
rbbp68.778e-2030.77retinoblastoma binding protein 6 [Source:ZFIN;Acc:... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000010453.12.146e-2833.16pep scaffold:Pmarinus_7.0:GL483937:7299:12919:1 ge... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
MPE15.620e-2323.90Essential conserved subunit of CPF cleavage and po... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSORLT00000010826.24.374e-2328.73E3 ubiquitin-protein ligase RBBP6 [Source:NCBI gen... [more]
ENSORLT00000042274.14.788e-2328.73E3 ubiquitin-protein ligase RBBP6 [Source:NCBI gen... [more]
ENSORLT00000046531.15.602e-728.57RB binding protein 6, ubiquitin ligase [Source:NCB... [more]
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BLAST of E3 ubiquitin-protein ligase RBBP6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000023195.10.000e+099.84SMESG000023195.1[more]
SMESG000068426.12.363e-8142.01SMESG000068426.1[more]
SMESG000064788.16.586e-926.77SMESG000064788.1[more]
SMESG000064788.18.688e-825.37SMESG000064788.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027713 ID=SMED30027713|Name=E3 ubiquitin-protein ligase RBBP6|organism=Schmidtea mediterranea sexual|type=transcript|length=2017bp
TCTTTTTAATATAGATTTCAAATAAATATGAGCAAATTAGTATATTATAA
ATTCAAGTCTGAACTAAATCAACAACAAATTCCATTTGAAGGTTCAAATA
TTTCTGTGAAAGAATTAACTGATGCTATTCGAAAAAAGCATTCCAATTCT
CACTGCAATTTAGTTGTATATATGAAGGATATTATATCTAAAGAAGAGCG
AGCTTGTTCTGAAAATGAATTAATACCAGCTTTTTCTAACGTAATAATCA
AACGATTGCCTTTAACTGATCAATCTAAACATAATAAAATTAAAAAGATC
GCAAATCCTGAAAATTTTTCTAAAGTGGATCCATATAAAAATGCAAATGA
AAAAGAGTCTTTAAATATATTTAAAAGAATAAATTTAAATTCATCATCAA
TGACAGAAGAACAAAAAGTTGACACTGTAATTGAATCTGCTGCTACAAAC
TATAGAATTGTTGGTAAAAGAAATCCCTATGGAACGCCTCCATCAACATA
TACTTGCAATAAATGCAATATTCCTGGTCATTGGATAAATAATTGTCCCG
GAATTCCAGACAAAAACGGGAAACTCATTGATTCTCGACAAGTCAAACGT
CCAAGTGGAATTCCGGTTTGTGGATTGGTGGAAGTCGATGAAAACACTCC
AAACAGTTATTTAACTCCAGATGGTCGATATGTAGTTAATATAAAAAACC
GTGATGCTCTTTTGAAAGGAAAAAAGGATAAACGTCCGTTTTCAATTGAA
GAAAATCCTCCGTTAGTCAAGCAACCGAAAAATGAAATTCCCGAAAATAT
GGTTTGCAGGTTGTGCTCGAATCTAATAACAGCACCGACGAAAACCGCCT
GCTGCAACAATACATATTGTCGAAACTGTATTACTGACCACTTATTCGAT
CCGGAAAACTCCACCATGATGCATCAATGCCCGAATTGCTTGGGAAAAAT
CGATAAATTGGATGAATTAATCGACGATTCCGAACTGGAAAATCTTATTC
ACATATGGAAAATCAGTAAAATTCCCAAAATAACGGAATTGACAAAAACT
CCGATAAATTCCGTGAAATTGGAAGCAAAACTCCCGAGCGCAATGACAGA
TGACGATTTGCTGAATGAGATATTCACCACGGAAAACAAGGAAAACGACC
ACCCGACAGCAGCCGATTGGGAATTCGCCAGTCAGCCGGTGAGCAAATCC
GAGCATTTATCACAGGATCCGAATATCCGATCGACAAATCCCACTGGCGA
TCAATTATTGTCGGATAGAGCCACAGCGGAAATGATCCGGAAACTGGCGA
GTGCCGACTGTGCCGAGGGGATTGTTGAGCTGATGAAGTCGAATCCCAAG
GCAATTCAACTGATTCAAGGACTCGTAAACAGCCTCGTGCCGGAAAACAC
CAACAATAACCATTACAAACATCGGAGTCGATCGAGACCGAGTGAGCCTC
GCCACCACCGACGGAACGAAACCGAATTCCGCCATCAGCCAATTAAACAT
CGAGATGAGTCGAGAAATTCCTACCGAAAATCCCAGAAACCAACTGAGAA
TCGGCAATTCCAAAATCGATATCCAACCGCTAATAGAAATGTCCATCCTA
GCCGGGAGGAACAACAGCGCCAGAACGGCTCCAATTCATCACCATTATCA
TTGTCATCATCGTGTCAGCGGCGGCATGACAACCACCGACAGATCGATAA
TCAATATCGGAAACGCCGAGCCAGTCGCAGCCAATCACCAATCAAAATCA
ACAGCCAATCCCTTGAGAGGAATTCGAACAGGCGAATTAAAAAATCGAAA
AAATATAAACATGAAAGAAGGACAGAGAAAAAATCCGAATATTTTCCGTC
AGATTAATTGATACTTTATTTATATGACAATAAAATTGTTTTTATTTTAT
TTTTGTATTTTTAACGGGACGATTTTTTTGGGGGAATTCGTGGTTTTATT
AGGGTATATCGATGTTTATGTGAGATTTTTGTGGTAAATAATATATTCTA
TATGTGATTTATTGAGA
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protein sequence of SMED30027713-orf-1

>SMED30027713-orf-1 ID=SMED30027713-orf-1|Name=SMED30027713-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=610bp
MSKLVYYKFKSELNQQQIPFEGSNISVKELTDAIRKKHSNSHCNLVVYMK
DIISKEERACSENELIPAFSNVIIKRLPLTDQSKHNKIKKIANPENFSKV
DPYKNANEKESLNIFKRINLNSSSMTEEQKVDTVIESAATNYRIVGKRNP
YGTPPSTYTCNKCNIPGHWINNCPGIPDKNGKLIDSRQVKRPSGIPVCGL
VEVDENTPNSYLTPDGRYVVNIKNRDALLKGKKDKRPFSIEENPPLVKQP
KNEIPENMVCRLCSNLITAPTKTACCNNTYCRNCITDHLFDPENSTMMHQ
CPNCLGKIDKLDELIDDSELENLIHIWKISKIPKITELTKTPINSVKLEA
KLPSAMTDDDLLNEIFTTENKENDHPTAADWEFASQPVSKSEHLSQDPNI
RSTNPTGDQLLSDRATAEMIRKLASADCAEGIVELMKSNPKAIQLIQGLV
NSLVPENTNNNHYKHRSRSRPSEPRHHRRNETEFRHQPIKHRDESRNSYR
KSQKPTENRQFQNRYPTANRNVHPSREEQQRQNGSNSSPLSLSSSCQRRH
DNHRQIDNQYRKRRASRSQSPIKINSQSLERNSNRRIKKSKKYKHERRTE
KKSEYFPSD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006397mRNA processing
GO:0016567protein ubiquitination
Vocabulary: molecular function
TermDefinition
GO:0061630ubiquitin protein ligase activity
GO:0008270zinc ion binding
GO:0003676nucleic acid binding
GO:0005515protein binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR033489RBBP6
IPR036875Znf_CCHC_sf
IPR014891DWNN_domain
IPR025829Zn_knuckle_CX2CX3GHX4C
IPR013083Znf_RING/FYVE/PHD
IPR001878Znf_CCHC
IPR001841Znf_RING
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR014891DWNN domainSMARTSM01180DWNN_2coord: 5..78
e-value: 1.0E-9
score: 48.3
IPR014891DWNN domainPFAMPF08783DWNNcoord: 5..78
e-value: 4.1E-13
score: 49.4
IPR014891DWNN domainPROSITEPS51282DWNNcoord: 5..78
score: 13.473
NoneNo IPR availableGENE3DG3DSA:3.10.20.90coord: 1..82
e-value: 2.6E-13
score: 51.5
NoneNo IPR availableGENE3DG3DSA:4.10.60.10coord: 153..206
e-value: 4.1E-12
score: 48.1
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 504..546
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 388..410
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 547..564
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 456..609
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 386..410
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 474..503
NoneNo IPR availablePANTHERPTHR15439:SF0E3 UBIQUITIN-PROTEIN LIGASE RBBP6coord: 1..324
NoneNo IPR availableCDDcd16620vRING-HC-C4C4_RBBP6coord: 255..304
e-value: 1.47013E-11
score: 57.2537
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 251..329
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 246..334
e-value: 2.0E-11
score: 45.4
IPR025829Zinc knuckle CX2CX3GHX4CPFAMPF13696zf-CCHC_2coord: 155..174
e-value: 1.4E-6
score: 28.0
IPR033489E3 ubiquitin-protein ligase RBBP6 familyPANTHERPTHR15439RETINOBLASTOMA-BINDING PROTEIN 6coord: 1..324
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 260..304
score: 9.317
IPR036875Zinc finger, CCHC-type superfamilySUPERFAMILYSSF57756Retrovirus zinc finger-like domainscoord: 149..181