TRAF-5

Overview
NameTRAF-5
Smed IDSMED30027690
Length (bp)743
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TRAF-5 (SMED30027690) t-SNE clustered cells

Violin plots show distribution of expression levels for TRAF-5 (SMED30027690) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TRAF-5 (SMED30027690) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TRAF-5 (SMED30027690) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027690

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30027690 SmedASXL_073653SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30027690 SmedASXL_073653SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
epidermisSMED30027690 dd_Smed_v4_10906_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30027690 dd_Smed_v4_10906_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30027690 dd_Smed_v4_10906_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TRAF-5 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 36.1946 bits (82), Expect = 8.623e-6
Identity = 39/134 (29.10%), Postives = 59/134 (44.03%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIR-KFREINC--QDCNELTLFSESDIHSENICKNQLIKCDDC--DVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNCFFK-IGC 726
            IY +  ++ C++ ++L +L  HLK    F E+ C   DC E  L  +   H E  CK +   C  C   V M          L+ H  +  C  +   C ++CS +      + +HL EC   P+ C FK  GC
Sbjct:  115 IYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMI--------ALQKHE-DTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGC 239

HSP 2 Score: 32.3426 bits (72), Expect = 8.623e-6
Identity = 17/52 (32.69%), Postives = 24/52 (46.15%), Query Frame = 2 
Query:  128 EKFIHFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLC 283
            EKF+   E     ++ CE C  +L    QTECG R+C +C+          C
Sbjct:   41 EKFVKTVE----DKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKC 88
[Close]
BLAST of TRAF-5 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 36.1946 bits (82), Expect = 8.623e-6
Identity = 39/134 (29.10%), Postives = 59/134 (44.03%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIR-KFREINC--QDCNELTLFSESDIHSENICKNQLIKCDDC--DVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNCFFK-IGC 726
            IY +  ++ C++ ++L +L  HLK    F E+ C   DC E  L  +   H E  CK +   C  C   V M          L+ H  +  C  +   C ++CS +      + +HL EC   P+ C FK  GC
Sbjct:  115 IYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMI--------ALQKHE-DTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGC 239

HSP 2 Score: 32.3426 bits (72), Expect = 8.623e-6
Identity = 17/52 (32.69%), Postives = 24/52 (46.15%), Query Frame = 2 
Query:  128 EKFIHFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLC 283
            EKF+   E     ++ CE C  +L    QTECG R+C +C+          C
Sbjct:   41 EKFVKTVE----DKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKC 88
[Close]
BLAST of TRAF-5 vs. Ensembl Zebrafish
Match: traf3 (TNF receptor-associated factor 3 [Source:ZFIN;Acc:ZDB-GENE-040801-257])

HSP 1 Score: 40.0466 bits (92), Expect = 2.254e-8
Identity = 15/43 (34.88%), Postives = 25/43 (58.14%), Query Frame = 2 
Query:  176 CEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCPRNVICI 304
            CE C+ +L    QTECG R+C +CI     +   +CP +++ +
Sbjct:   56 CETCRLVLCNPRQTECGHRFCESCINELLSKPNPVCPADLLPL 98

HSP 2 Score: 36.5798 bits (83), Expect = 2.254e-8
Identity = 30/134 (22.39%), Postives = 55/134 (41.04%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQ--DCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNC-FFKIGCNQR 735
            +Y +     C + + L+ + +HL I  + E+ C    C E  +  +   H    CK++ + C+ C + M  +       L+ H    +C      C   CS        + SH  +CP+    C F + GC+ +
Sbjct:  118 VYCRSEKNGCKEQMCLQQVMEHLVICPYFEVPCPLGKCKEKMMRKDMPEHLSRKCKHREVTCEFCSLKMALT------ELQKHK-ETVCPAFPVACPNHCSFSSILRSELSSHQHDCPKAQVTCSFIRYGCSYK 244
[Close]
BLAST of TRAF-5 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 41.9726 bits (97), Expect = 1.436e-6
Identity = 38/132 (28.79%), Postives = 55/132 (41.67%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF-DNIKSHL-LECPRRPTNCFFK-IGCNQR 735
            + VKC N  CS+ + L+ L +HL   +F    C  C E    S  D H    C  +++ C DC        G+    +K  N  Q C    + C Y C  E   D +  H   +C + P  C F   GC ++
Sbjct:  131 LTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDC-------AGSFVYAVK-QNHEQFCPFANTVCEY-CEMELIRDQLALHCDTDCLKAPVACTFSTFGCREK 253

HSP 2 Score: 28.4906 bits (62), Expect = 1.436e-6
Identity = 14/41 (34.15%), Postives = 20/41 (48.78%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L    QT CG R+C +CI+       + CP
Sbjct:   67 SKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCP 107
[Close]
BLAST of TRAF-5 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 41.9726 bits (97), Expect = 1.436e-6
Identity = 38/132 (28.79%), Postives = 55/132 (41.67%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF-DNIKSHL-LECPRRPTNCFFK-IGCNQR 735
            + VKC N  CS+ + L+ L +HL   +F    C  C E    S  D H    C  +++ C DC        G+    +K  N  Q C    + C Y C  E   D +  H   +C + P  C F   GC ++
Sbjct:  131 LTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDC-------AGSFVYAVK-QNHEQFCPFANTVCEY-CEMELIRDQLALHCDTDCLKAPVACTFSTFGCREK 253

HSP 2 Score: 28.4906 bits (62), Expect = 1.436e-6
Identity = 14/41 (34.15%), Postives = 20/41 (48.78%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L    QT CG R+C +CI+       + CP
Sbjct:   67 SKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCP 107
[Close]
BLAST of TRAF-5 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 41.9726 bits (97), Expect = 1.436e-6
Identity = 38/132 (28.79%), Postives = 55/132 (41.67%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF-DNIKSHL-LECPRRPTNCFFK-IGCNQR 735
            + VKC N  CS+ + L+ L +HL   +F    C  C E    S  D H    C  +++ C DC        G+    +K  N  Q C    + C Y C  E   D +  H   +C + P  C F   GC ++
Sbjct:  131 LTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDC-------AGSFVYAVK-QNHEQFCPFANTVCEY-CEMELIRDQLALHCDTDCLKAPVACTFSTFGCREK 253

HSP 2 Score: 28.4906 bits (62), Expect = 1.436e-6
Identity = 14/41 (34.15%), Postives = 20/41 (48.78%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L    QT CG R+C +CI+       + CP
Sbjct:   67 SKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCP 107
[Close]
BLAST of TRAF-5 vs. Ensembl Zebrafish
Match: traf2b (Tnf receptor-associated factor 2b [Source:ZFIN;Acc:ZDB-GENE-030131-5345])

HSP 1 Score: 48.521 bits (114), Expect = 3.787e-6
Identity = 38/135 (28.15%), Postives = 62/135 (45.93%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLT-QHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNCFFK-IGCNQRCD 741
            +  KC N+ CS +  LK+   QH     F  + C+ C  L L SE D H+E  C+ + + C  C V          + +K+H  ++IC+K   +C  +C  +    +  + H   C +  + C F+ IGC    D
Sbjct:  114 LPAKCPNEGCSWSGTLKDFENQHEGRCAFERVKCEACQVLILLSEKDRHNERECEARTLNCKYCKVTFN------FKEIKAH--DEICQKFPMQC-KDCGKKKIPREKFQEHTKSCAKSKSACQFREIGCRAVVD 239
[Close]
BLAST of TRAF-5 vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 37.7354 bits (86), Expect = 7.620e-7
Identity = 38/134 (28.36%), Postives = 59/134 (44.03%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIR-KFREINC--QDCNELTLFSESDIHSENICKNQLIKCDDC--DVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNCFFK-IGC 726
            +Y +   + C++ + L +L  HLK   +F E+ C   DC E  L  +   H E  CK +   C  C   V M +        L+ H  +  C  +   C ++CS +      + +HL EC   P+ C FK  GC
Sbjct:  114 VYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIK--------LQKHE-DTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGC 238

HSP 2 Score: 33.8834 bits (76), Expect = 7.620e-7
Identity = 17/52 (32.69%), Postives = 25/52 (48.08%), Query Frame = 2 
Query:  128 EKFIHFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLC 283
            EKF+   E     ++ CE C+ +L    QTECG R+C +C+          C
Sbjct:   40 EKFVKTVE----DKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKC 87
[Close]
BLAST of TRAF-5 vs. UniProt/SwissProt
Match: sp|Q6DJN2|TRF6B_XENLA (TNF receptor-associated factor 6-B OS=Xenopus laevis OX=8355 GN=traf6-b PE=2 SV=1)

HSP 1 Score: 49.6766 bits (117), Expect = 1.248e-7
Identity = 34/129 (26.36%), Postives = 62/129 (48.06%), Query Frame = 1 
Query:  355 VKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHL-LECPRRPTNC-FFKIGCNQR 735
            VKC ++ C++ + L++L +HL   +F  + C  C      S  + H E+ C  + I CD+C + M       + ++  H L  IC      C Y  +N   + + SH  ++C   P  C +++ GC ++
Sbjct:  134 VKCPSQGCTETMELRHLERHLGQCQFASVECSQCQGSFPKSRLEKHMEHECGRRKIFCDNCGLAM------AYEDMSGHEL--ICPLAYVTCEYCQTNLIREQMPSHYSMDCTMAPIPCMYYEFGCTEK 254

HSP 2 Score: 26.9498 bits (58), Expect = 1.248e-7
Identity = 14/41 (34.15%), Postives = 18/41 (43.90%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L +  QT CG R+C  CI          CP
Sbjct:   68 SKYECPICLMALREAVQTPCGHRFCKACIVKSLRDAGHKCP 108
[Close]
BLAST of TRAF-5 vs. UniProt/SwissProt
Match: sp|Q3MV19|TRF6A_XENLA (TNF receptor-associated factor 6-A OS=Xenopus laevis OX=8355 GN=traf6-a PE=1 SV=1)

HSP 1 Score: 45.4394 bits (106), Expect = 1.556e-6
Identity = 35/131 (26.72%), Postives = 58/131 (44.27%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHL-LECPRRPTNCFF-KIGCNQR 735
            + VKC N  C+D + L++L  HL   +F  + C  C    L    D H E+ C  +   CD+C + M       + +   H L  IC      C Y  +N   + + +H  ++C   P  C + + GC ++
Sbjct:  132 LRVKCPNLGCTDTMELRHLEHHLVQCQFASVECSQCQGSFLKLLLDKHMEHECGRRRTFCDNCGLAM------AYEDKSGHEL--ICPMAYVTCDYCQTNLIREQMPAHYSMDCTMAPIPCMYCEFGCREK 254

HSP 2 Score: 27.7202 bits (60), Expect = 1.556e-6
Identity = 18/62 (29.03%), Postives = 25/62 (40.32%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP-RNVICIRQHYARQSNIKRNF 346
            S++ C  C   L +  QT CG R+C  CI          CP  N I + +     +  KR  
Sbjct:   68 SKYECPICLMALREAVQTPCGHRFCKACILKSLRNAGHKCPVDNEILMEKQLFPDNFAKREI 129
[Close]
BLAST of TRAF-5 vs. UniProt/SwissProt
Match: sp|Q60803|TRAF3_MOUSE (TNF receptor-associated factor 3 OS=Mus musculus OX=10090 GN=Traf3 PE=1 SV=2)

HSP 1 Score: 37.7354 bits (86), Expect = 4.368e-6
Identity = 38/134 (28.36%), Postives = 59/134 (44.03%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIR-KFREINC--QDCNELTLFSESDIHSENICKNQLIKCDDC--DVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNCFFK-IGC 726
            +Y +   + C++ + L +L  HLK   +F E+ C   DC E  L  +   H E  CK +   C  C   V M +        L+ H  +  C  +   C ++CS +      + +HL EC   P+ C FK  GC
Sbjct:  114 VYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIK--------LQKHE-DTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGC 238

HSP 2 Score: 33.8834 bits (76), Expect = 4.368e-6
Identity = 17/52 (32.69%), Postives = 25/52 (48.08%), Query Frame = 2 
Query:  128 EKFIHFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLC 283
            EKF+   E     ++ CE C+ +L    QTECG R+C +C+          C
Sbjct:   40 EKFVKTVE----DKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKC 87
[Close]
BLAST of TRAF-5 vs. UniProt/SwissProt
Match: sp|Q6IWL4|TRAF6_DANRE (TNF receptor-associated factor 6 OS=Danio rerio OX=7955 GN=traf6 PE=1 SV=2)

HSP 1 Score: 41.9726 bits (97), Expect = 8.409e-6
Identity = 38/132 (28.79%), Postives = 55/132 (41.67%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF-DNIKSHL-LECPRRPTNCFFK-IGCNQR 735
            + VKC N  CS+ + L+ L +HL   +F    C  C E    S  D H    C  +++ C DC        G+    +K  N  Q C    + C Y C  E   D +  H   +C + P  C F   GC ++
Sbjct:  131 LTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDC-------AGSFVYAVK-QNHEQFCPFANTVCEY-CEMELIRDQLALHCDTDCLKAPVACTFSTFGCREK 253

HSP 2 Score: 28.4906 bits (62), Expect = 8.409e-6
Identity = 14/41 (34.15%), Postives = 20/41 (48.78%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L    QT CG R+C +CI+       + CP
Sbjct:   67 SKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCP 107
[Close]
BLAST of TRAF-5 vs. TrEMBL
Match: T1DF65 (TRAF-2 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 65.0846 bits (157), Expect = 1.871e-12
Identity = 42/126 (33.33%), Postives = 65/126 (51.59%), Query Frame = 1 
Query:  361 CVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRS-LGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLECPRRPTNCFF-KIGCNQ 732
            C NK C     +K+L  HL+  ++ E  C  CNE     E   H E  CK  +  C+DC + +++  L   H+N+ +  ++ +C K    C ++CS +   NIK HLL C RRP  C   ++GC +
Sbjct:   98 CTNKGCEYTCKVKDLDNHLETCEYIEKRCTACNESYPRKELKKHEEFTCKMIITTCEDCGLELSKGDLEKKHKNV-NELIDNVCSKWRDICPFKCSEDTLVNIKDHLLTCERRPVECSLNEMGCRK 222

HSP 2 Score: 35.8094 bits (81), Expect = 1.871e-12
Identity = 17/52 (32.69%), Postives = 28/52 (53.85%), Query Frame = 2 
Query:  131 KFIHFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            K  +F+  +   R  C  C ++L++ +QT+CG R CS C++      E  CP
Sbjct:   17 KLFYFECEQQKQRISCVKCHQVLIEPYQTQCGCRLCSNCLEECSKDEESHCP 68
[Close]
BLAST of TRAF-5 vs. TrEMBL
Match: D5JG60 (TNF receptor-associated factor-2-like protein B OS=Dugesia japonica OX=6161 GN=TRAF-2B PE=2 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 3.616e-11
Identity = 45/130 (34.62%), Postives = 65/130 (50.00%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRS-LGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLECPRRPTNCFF-KIGCNQ 732
            + VKC+   C  + +LK++  HL     + INC+ CNE     E   H+E  C  +L+ C  C   M  S L  +H N+ +  L   C KL  KC Y+C N    N+  H   C ++P  C F +IGCN+
Sbjct:   89 LTVKCLFPGCEHSELLKDIGDHLDSCIHQTINCKSCNEELTKIELKEHTEKKCPMRLVSCTHCGEEMEYSNLTELHLNVHTEKL---CAKLVGKCPYKCDNGKEVNLLDHRKSCSKKPVTCLFSEIGCNR 215

HSP 2 Score: 31.5722 bits (70), Expect = 3.616e-11
Identity = 12/28 (42.86%), Postives = 19/28 (67.86%), Query Frame = 2 
Query:  176 CEACKEILVQHHQTECGLRYCSTCIKNW 259
            C  C ++L++  QT+CG RYC  C+K +
Sbjct:   30 CIICSQLLLEALQTDCGCRYCKECLKEY 57
[Close]
BLAST of TRAF-5 vs. TrEMBL
Match: T1D122 (TRAF-5 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 69.3218 bits (168), Expect = 7.673e-10
Identity = 45/146 (30.82%), Postives = 71/146 (48.63%), Query Frame = 1 
Query:  298 LYKTTLCKTKQYKKK-F*IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRS-LGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLECPRRPTNCFFK-IGC 726
            + K +L + K  +K+   + V+C  + C +N++ +    H +   +    C+ C E  + S  + H    C   ++KCDDC   M R  L  VH+N    +   +CEK   KC Y+C+ E + N+K H   C  R T C  K IGC
Sbjct:   65 IEKVSLIRDKAIEKEIMRMRVQCPQEGCGENIMYREWGGHERACVYGVNECEKCGEEYVRSRKEDHEREECGESVVKCDDCGKEMRREDLKNVHKNYDG-DEESLCEKWMCKCPYQCTEEQYVNMKEHASSCRERCTPCPLKDIGC 209
[Close]
BLAST of TRAF-5 vs. TrEMBL
Match: A0A2U9CI95 (Putative TNF receptor-associated factor 3 OS=Scophthalmus maximus OX=52904 GN=SMAX5B_021798 PE=4 SV=1)

HSP 1 Score: 48.1358 bits (113), Expect = 1.534e-9
Identity = 20/52 (38.46%), Postives = 31/52 (59.62%), Query Frame = 2 
Query:  140 HFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCPRNV 295
            HF E    +++ CE C+ +L Q  QTECG R+C +CI N   +   +CP ++
Sbjct:  458 HFVE-TPEAKYCCEVCRLVLCQPRQTECGHRFCQSCIHNILSQPNPVCPADM 508

HSP 2 Score: 42.743 bits (99), Expect = 1.534e-9
Identity = 31/132 (23.48%), Postives = 52/132 (39.39%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQ--DCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNCFF-KIGCN 729
            +Y +     C + + L  +  HL +  F E+ C    C E  +  E   H    CK++   C+ C   M  +      +L+ H    +C      C   CS        + SH  +CP+   +C F + GC+
Sbjct:  531 VYCRSEANGCQEQMSLHQIPDHLNVCPFFEVPCPLGKCKERMMRKEIPDHLSWKCKHRETTCEFCITKMPLT------DLQKHK-ETVCPAFPVSCPNHCSFSSLPRSELSSHQHDCPKAQVSCLFHRYGCS 655
[Close]
BLAST of TRAF-5 vs. TrEMBL
Match: A0A1I8G6V3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 62.7734 bits (151), Expect = 1.744e-9
Identity = 40/133 (30.08%), Postives = 67/133 (50.38%), Query Frame = 1 
Query:  355 VKCVN--KNCSDNVVLKNLTQHLKIR-KFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRS-LGTVHRNLKSHNLNQICEKLTSKCVYECSNE----DFDNIKSHLLECPRRPTNC-FFKIGC 726
            V+C N    CS  +    + QH++    +  + C+ C EL L  +   H+ + C+++   CD C  ++T S + T HRNL+S   +  C + +++C + CS      D     +HL ECP RP  C +  +GC
Sbjct: 1729 VRCPNCDAGCSVQLEWARMDQHVQQSCDWHSLRCEQCKELILKKDMQRHTSSECRHRKETCDLCSQLVTHSEMETSHRNLQS---DVCCPRFSARCPH-CSERSTPMDRRGYVAHLSECPERPVECKYSHLGC 1857

HSP 2 Score: 27.7202 bits (60), Expect = 1.744e-9
Identity = 13/38 (34.21%), Postives = 16/38 (42.11%), Query Frame = 2 
Query:  176 CEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKL-CP 286
            C +C + L    QT  G R C  C+       EK  CP
Sbjct: 1652 CSSCSKPLFNARQTPHGCRLCQACVTGLLHEVEKRPCP 1689
[Close]
BLAST of TRAF-5 vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 41.5874 bits (96), Expect = 5.966e-6
Identity = 38/132 (28.79%), Postives = 59/132 (44.70%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDN-IKSHL-LECPRRPTNCFFKI-GCNQR 735
            + V+C N  C + + L++L  H+   KF  + C  C E    SE + H    C ++LI C DC   +  +    H         Q+C    + C Y C+ E   N + SH   +C + P  C F I GC ++
Sbjct:  130 LTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQFH--------EQLCLFANTVCEY-CNMELIRNQLASHCDTDCLKAPVACTFSIFGCREK 252

HSP 2 Score: 26.5646 bits (57), Expect = 5.966e-6
Identity = 14/41 (34.15%), Postives = 20/41 (48.78%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L    QT CG R+C+ CI+       + CP
Sbjct:   66 SKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCP 106
[Close]
BLAST of TRAF-5 vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 41.5874 bits (96), Expect = 5.966e-6
Identity = 38/132 (28.79%), Postives = 59/132 (44.70%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDN-IKSHL-LECPRRPTNCFFKI-GCNQR 735
            + V+C N  C + + L++L  H+   KF  + C  C E    SE + H    C ++LI C DC   +  +    H         Q+C    + C Y C+ E   N + SH   +C + P  C F I GC ++
Sbjct:  130 LTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQFH--------EQLCLFANTVCEY-CNMELIRNQLASHCDTDCLKAPVACTFSIFGCREK 252

HSP 2 Score: 26.5646 bits (57), Expect = 5.966e-6
Identity = 14/41 (34.15%), Postives = 20/41 (48.78%), Query Frame = 2 
Query:  164 SRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            S++ C  C   L    QT CG R+C+ CI+       + CP
Sbjct:   66 SKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCP 106
[Close]
BLAST of TRAF-5 vs. Ensembl Cavefish
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:103028261])

HSP 1 Score: 46.9802 bits (110), Expect = 9.062e-6
Identity = 37/135 (27.41%), Postives = 62/135 (45.93%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNL-TQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDF--DNIKSHLLECPRRPTNC-FFKIGCNQRCD 741
            +  KC N  CS N  LK    QH    +F  + C+ C  + L S+ D H+E  C+ + + C  C V  +       +++K+H  ++IC+K   +C  +C  +    +    H   C +  + C F +IGC    D
Sbjct:  111 LPAKCPNDGCSWNGTLKEYEVQHEGRCEFERVKCEACQMMILLSDKDRHNERECEARTLNCKYCKVTFS------FKDIKAH--DEICQKFPMQC-KDCGKKKIPREKFAEHSKSCAKSKSACQFSEIGCRAVVD 236
[Close]
BLAST of TRAF-5 vs. Ensembl Medaka
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:101161132])

HSP 1 Score: 46.595 bits (109), Expect = 7.977e-8
Identity = 34/131 (25.95%), Postives = 58/131 (44.27%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHL-LECPRRPTNCFFKI-GCNQR 735
            + V+C N +C + + L++L +HL   +F  + C  C +    S  + H+   C  + + C DC  +       +H         Q C   +  C Y   +   D ++SH   +CP+ P  C F I GC +R
Sbjct:  138 LTVRCPNSDCGEKMELRHLEKHLAQCQFATVPCSQCQQPVRKSYLEEHATVECPRRPMSCPDCVAVFVYEEREMH--------EQQCPFASVMCQYCEMDLIRDQMESHCDTDCPKAPIACTFSIFGCKER 260

HSP 2 Score: 28.1054 bits (61), Expect = 7.977e-8
Identity = 14/42 (33.33%), Postives = 20/42 (47.62%), Query Frame = 2 
Query:  161 NSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
             S++ C  C   L    QT CG R+C +CI+       + CP
Sbjct:   73 ESKYECPICLMALRNAIQTRCGHRFCKSCIEKSIRDTGQRCP 114
[Close]
BLAST of TRAF-5 vs. Planmine SMEST
Match: SMESG000018435.1 (SMESG000018435.1)

HSP 1 Score: 76.6406 bits (187), Expect = 4.079e-21
Identity = 44/126 (34.92%), Postives = 71/126 (56.35%), Query Frame = 1 
Query:  355 VKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTR-SLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLECPRRPTNCF-FKIGC 726
            ++C+   C      K L  HL++ K+R  NC  C +       +IH +  C N + KC  C + MTR    T H N+    ++++CE L+ KC YEC++E  +NI++HL +CP + T CF +++GC
Sbjct:   95 IRCLLNGCDHIGQFKYLDDHLRMCKWRLENCDKCPQTYPKQMKEIHLQEECVNGICKCSKCGLEMTRHEYQTFHVNINVECIDKLCENLSGKCPYECNSEIHNNIRNHLYDCPNKVTKCFLYELGC 220

HSP 2 Score: 42.743 bits (99), Expect = 4.079e-21
Identity = 19/40 (47.50%), Postives = 24/40 (60.00%), Query Frame = 2 
Query:  167 RFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            RF C  C EIL+   QT+CG R+C +CI   F   E +CP
Sbjct:   31 RFVCSKCHEILIDPSQTQCGCRFCYSCINKHFASCENICP 70
[Close]
BLAST of TRAF-5 vs. Planmine SMEST
Match: SMESG000018409.1 (SMESG000018409.1)

HSP 1 Score: 77.7962 bits (190), Expect = 8.130e-21
Identity = 45/126 (35.71%), Postives = 72/126 (57.14%), Query Frame = 1 
Query:  355 VKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTR-SLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLECPRRPTNCF-FKIGC 726
            ++C+   C      K L  HLK+ K+R  NC  C++       +IH +  C N + KC  C + MTR    T H N+    ++++CE L+ KC YEC++E  +NI++HL +CP + T CF +++GC
Sbjct:   93 IRCLLNGCDHIGQFKYLDDHLKMCKWRLENCDKCHQTYPKQMKEIHLQEECVNGICKCSKCGLEMTRHEYQTFHVNINVECIDKLCENLSGKCPYECNSEIHNNIRNHLYDCPNKVTKCFLYELGC 218

HSP 2 Score: 40.4318 bits (93), Expect = 8.130e-21
Identity = 18/40 (45.00%), Postives = 23/40 (57.50%), Query Frame = 2 
Query:  167 RFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            RF C  C EIL+   QT+CG R+C +CI   F     +CP
Sbjct:   29 RFVCSKCHEILIDPSQTQCGCRFCYSCINKHFASCGNICP 68
[Close]
BLAST of TRAF-5 vs. Planmine SMEST
Match: SMESG000018404.1 (SMESG000018404.1)

HSP 1 Score: 68.1662 bits (165), Expect = 1.171e-15
Identity = 43/130 (33.08%), Postives = 67/130 (51.54%), Query Frame = 1 
Query:  355 VKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTRSLGTV-HRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLECPRRPTNCFFK-IGCNQRC 738
            +KC N+ C +  +LK L  H +  ++R   C  C +L  F   + H   +C+ +++ CD+C   MT +   + HRN++   ++ +C+K    C   CSN D   IK HL ECP    NC F  +GC  R 
Sbjct:   63 IKCPNERCDEIFLLKELKNHSETCQYRMKQCDLCQQLYQFKFKEQHMNELCERRIVTCDECQQQMTSNDHEINHRNIEM-GIDNLCDKWIDVCPQRCSNGDKVVIKMHLKECPNSQVNCPFSNVGCTTRA 191

HSP 2 Score: 32.7278 bits (73), Expect = 1.171e-15
Identity = 12/35 (34.29%), Postives = 20/35 (57.14%), Query Frame = 2 
Query:  182 ACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
              + + ++  QTECG R+C  CI+N+ +     CP
Sbjct:    3 TLQNVFIEPIQTECGCRFCYNCIENYINNSNSSCP 37
[Close]
BLAST of TRAF-5 vs. Planmine SMEST
Match: SMESG000047778.1 (SMESG000047778.1)

HSP 1 Score: 56.6102 bits (135), Expect = 3.477e-13
Identity = 38/113 (33.63%), Postives = 56/113 (49.56%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFREINCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIMTR-SLGTVHRNLKSHNLNQICEKLTSKCVYECSNEDFDNIKSHLLE 684
            I + C+N NC   + L NL +HL+      INC+ C    L      H    C N+ + C  C  +M       +H N++  N  ++CE  T  C Y+CS+E + NIK HL+E
Sbjct:  125 ISISCINDNCQVKMFLPNLHRHLQQCPESVINCKKCFVKILLKTQFDHETVNCINRSVTCAMCQKVMPAFQYENIHLNIE--NPLELCENFTRSCPYKCSDEKYHNIKRHLIE 235

HSP 2 Score: 36.1946 bits (82), Expect = 3.477e-13
Identity = 15/44 (34.09%), Postives = 22/44 (50.00%), Query Frame = 2 
Query:  155 KTNSRFYCEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            K  +RF+C+ C  ++    Q  CG R+C  C  N+F      CP
Sbjct:   57 KLKTRFFCKLCNSLMNVPVQMNCGCRFCDKCCDNYFQLRSTKCP 100
[Close]
BLAST of TRAF-5 vs. Planmine SMEST
Match: SMESG000019697.1 (SMESG000019697.1)

HSP 1 Score: 48.521 bits (114), Expect = 2.393e-12
Identity = 42/133 (31.58%), Postives = 68/133 (51.13%), Query Frame = 1 
Query:  349 IYVKCVNKNCSDNVVLKNLTQHLKIRKFRE---INCQDCNELTLFSESDIHSENICKNQLIKCDDCDVIM-TRSLGTVHRNLKSHNLNQICEKLTSKCVYECS-NEDFDNIKSHLLECPRRPTNC-FFKIGCN 729
            + VKC    C     +K+L  H+ I +F     +N ++ N+L  F E   HS        ++CD CD+I+    + + H N++S   +  CE+ T KC YEC+ ++D   +K H+  C  +P  C FF  GC+
Sbjct:   93 LVVKCPFNPCCHICSIKDLDNHINICQFNMPDIVNVEETNDLGEFEE---HS--------VRCDFCDLIVDVDEMKSRHHNIES---DDFCEQFTGKCPYECNFDDDSFPLKHHIRICINKPVPCPFFSQGCD 211

HSP 2 Score: 41.2022 bits (95), Expect = 2.393e-12
Identity = 15/37 (40.54%), Postives = 25/37 (67.57%), Query Frame = 2 
Query:  176 CEACKEILVQHHQTECGLRYCSTCIKNWFDRHEKLCP 286
            C+ CK +LV   Q+ECG R+C  C++N+ +   ++CP
Sbjct:   28 CKICKGVLVDAKQSECGCRFCEKCLQNYINSGNEICP 64
The following BLAST results are available for this feature:
BLAST of TRAF-5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
TRAF38.623e-629.10TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF38.623e-629.10TNF receptor associated factor 3 [Source:HGNC Symb... [more]
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BLAST of TRAF-5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TRAF-5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TRAF-5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf32.254e-834.88TNF receptor-associated factor 3 [Source:ZFIN;Acc:... [more]
traf61.436e-628.79TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf61.436e-628.79TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf61.436e-628.79TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf2b3.787e-628.15Tnf receptor-associated factor 2b [Source:ZFIN;Acc... [more]
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BLAST of TRAF-5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TRAF-5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Traf37.620e-728.36TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
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BLAST of TRAF-5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4
Match NameE-valueIdentityDescription
sp|Q6DJN2|TRF6B_XENLA1.248e-726.36TNF receptor-associated factor 6-B OS=Xenopus laev... [more]
sp|Q3MV19|TRF6A_XENLA1.556e-626.72TNF receptor-associated factor 6-A OS=Xenopus laev... [more]
sp|Q60803|TRAF3_MOUSE4.368e-628.36TNF receptor-associated factor 3 OS=Mus musculus O... [more]
sp|Q6IWL4|TRAF6_DANRE8.409e-628.79TNF receptor-associated factor 6 OS=Danio rerio OX... [more]
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BLAST of TRAF-5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1DF651.871e-1233.33TRAF-2 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
D5JG603.616e-1134.62TNF receptor-associated factor-2-like protein B OS... [more]
T1D1227.673e-1030.82TRAF-5 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
A0A2U9CI951.534e-938.46Putative TNF receptor-associated factor 3 OS=Scoph... [more]
A0A1I8G6V31.744e-930.08Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of TRAF-5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
traf65.966e-628.79TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf65.966e-628.79TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf2b9.062e-627.41TNF receptor associated factor 2 [Source:NCBI gene... [more]
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BLAST of TRAF-5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TRAF-5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TRAF-5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TRAF-5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
traf67.977e-825.95TNF receptor associated factor 6 [Source:NCBI gene... [more]
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BLAST of TRAF-5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000018435.14.079e-2134.92SMESG000018435.1[more]
SMESG000018409.18.130e-2135.71SMESG000018409.1[more]
SMESG000018404.11.171e-1533.08SMESG000018404.1[more]
SMESG000047778.13.477e-1333.63SMESG000047778.1[more]
SMESG000019697.12.393e-1231.58SMESG000019697.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027690 ID=SMED30027690|Name=TRAF-5|organism=Schmidtea mediterranea sexual|type=transcript|length=743bp
TTTAAATGTAGGCAATTTGGAAAATCCAAGTTTTTGTTGCTATTTATAGA
ACAACCTGAATCATAAATAATTACCACCATAAATATATTTAATTTAAATG
GCTATCAAATTTGATTATCATAATTTGGAAAAATTTATCCATTTCCAAGA
GTGTAAAACCAATTCTAGATTCTATTGCGAAGCTTGCAAAGAAATTCTTG
TCCAACATCATCAAACGGAATGTGGTCTCAGGTATTGTTCAACGTGCATC
AAAAATTGGTTTGATAGGCACGAAAAGCTCTGTCCAAGAAATGTCATCTG
TATAAGACAACATTATGCAAGACAAAGCAATATAAAAAGAAATTTTAAAT
TTATGTCAAATGCGTTAATAAAAATTGTAGTGACAATGTCGTTTTGAAAA
ATTTAACTCAACATTTGAAGATTCGTAAATTCAGAGAAATAAATTGCCAA
GATTGTAATGAATTGACACTATTTTCTGAAAGTGATATACATTCTGAAAA
TATCTGTAAAAATCAGTTAATAAAGTGTGATGATTGTGATGTAATTATGA
CGAGAAGTTTAGGAACAGTGCATCGAAATTTAAAGTCTCATAATCTAAAT
CAAATATGTGAAAAATTGACGTCTAAATGTGTTTATGAGTGTAGTAATGA
GGATTTCGATAACATTAAATCACATTTACTCGAATGTCCCAGGCGACCGA
CTAATTGTTTTTTTAAAATTGGATGTAATCAAAGGTGCGATAA
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protein sequence of SMED30027690-orf-1

>SMED30027690-orf-1 ID=SMED30027690-orf-1|Name=SMED30027690-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=100bp
MAIKFDYHNLEKFIHFQECKTNSRFYCEACKEILVQHHQTECGLRYCSTC
IKNWFDRHEKLCPRNVICIRQHYARQSNIKRNFKFMSNALIKIVVTMSF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
GO:0042981regulation of apoptotic process
GO:0016567protein ubiquitination
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR013083Znf_RING/FYVE/PHD
IPR018957Znf_C3HC4_RING-type
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
GO:0004842ubiquitin-protein transferase activity
GO:0008270zinc ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR018957Zinc finger, C3HC4 RING-typePFAMPF00097zf-C3HC4coord: 27..63
e-value: 4.1E-5
score: 23.4
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 10..98
e-value: 3.7E-9
score: 38.6
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 23..73