Bestrophin homolog

Overview
NameBestrophin homolog
Smed IDSMED30027686
Length (bp)1460
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bestrophin homolog (SMED30027686) t-SNE clustered cells

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30027686) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bestrophin homolog (SMED30027686) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30027686) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027686

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30027686h1SMcG0006823 Contig44489uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30027686h1SMcG0006823 Contig44489newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
pharynxSMED30027686h1SMcG0006823 dd_Smed_v4_8314_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30027686h1SMcG0006823 dd_Smed_v4_8314_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30027686h1SMcG0006823 dd_Smed_v4_8314_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30027686h1SMcG0006823 dd_Smed_v4_8314_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 315.849 bits (808), Expect = 2.632e-103
Identity = 149/341 (43.70%), Postives = 231/341 (67.74%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + ++ F RLLL+W+GSIYK+++ E IVFA LYT +S +YR  L G+ K+ FE+   +  + A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD +   +S+ + G+D+   + RRT+MRY+NL+  + F S+S+   + FP +  ++E G +T DE K+ N  ++ + KY+VP +W  NL  +A +E        +++L+ E+ ++R    +++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   K      +D+Y+P+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S L +DEMH S P++ KD++W+ +
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 316.62 bits (810), Expect = 2.655e-100
Identity = 149/341 (43.70%), Postives = 231/341 (67.74%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + ++ F RLLL+W+GSIYK+++ E IVFA LYT +S +YR  L G+ K+ FE+   +  + A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD +   +S+ + G+D+   + RRT+MRY+NL+  + F S+S+   + FP +  ++E G +T DE K+ N  ++ + KY+VP +W  NL  +A +E        +++L+ E+ ++R    +++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   K      +D+Y+P+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S L +DEMH S P++ KD++W+ +
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 301.212 bits (770), Expect = 3.158e-96
Identity = 148/340 (43.53%), Postives = 221/340 (65.00%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F   Y  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV+RWW+Q++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W SNL  QA  E        ++ L+EE+  FRG  GM++ +DWI+ PLVYTQ+ TI++++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 301.212 bits (770), Expect = 3.158e-96
Identity = 148/340 (43.53%), Postives = 221/340 (65.00%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F   Y  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV+RWW+Q++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W SNL  QA  E        ++ L+EE+  FRG  GM++ +DWI+ PLVYTQ+ TI++++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 301.212 bits (770), Expect = 3.158e-96
Identity = 148/340 (43.53%), Postives = 221/340 (65.00%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F   Y  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV+RWW+Q++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W SNL  QA  E        ++ L+EE+  FRG  GM++ +DWI+ PLVYTQ+ TI++++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-24 (Bestrophin homolog 24 [Source:UniProtKB/Swiss-Prot;Acc:P34672])

HSP 1 Score: 253.447 bits (646), Expect = 5.931e-77
Identity = 133/371 (35.85%), Postives = 224/371 (60.38%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFI------SKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPK--NDMFAGSLLNLNTDE 1241
            MTI Y   V+TSK WT  +LLL+W+GSI+K +  E+ V+  LY  LS +YR  L    ++ FE    +       IP+ F+LGF+VT VV+RW   +  I + D++ +  + ++ G  +++ MYRR I+RY  L+  + F  IS + +R FP L T++  G +   E+   +E +   +KY+VP  WA +L Y+A  + +   +     + +EI KFR  L  I  +DW+  P++Y Q+  ++VH YF++ + A Q++      +K ++D+Y P+   LQF+FYMGW+KVAE+++NPFG+DDDDFE + +I RNI M  +++D+ +D  P+L +D FW+   +++ ++  ++ K  N+   GS+ ++   E
Sbjct:    1 MTINYNLAVSTSKPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYVVSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAPDLKRDDFWDE--EVEPLYSEETAKIPNNPLKGSVSDVKLPE 369
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-7 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q18303])

HSP 1 Score: 248.44 bits (633), Expect = 6.821e-76
Identity = 125/339 (36.87%), Postives = 207/339 (61.06%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQF------ISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MT  Y   +ATS+    L+L+ +WKGS++K I+ ++IV+   Y  +S +YR+ L    +  FE F  F  +  D IP+ F+LGF+VT V++RW  QF  +   D++A++ S ++ GND++  + RR+I+R   +S  M F  I    ++ FP L+T++  G++T  E K  NE E+  AKY++   W  NL+ +A  E           + EEI  FR  L +I+ +DW+  PL+Y Q+  +++H Y+++ + + QF      ++  ++D+ VP    ++F+FYMGWLKVA  L+NPFG+D+DDF+ + +I RN+ ++  I+D+ HD  P L+KD+FWN
Sbjct:    1 MTYNYHYDLATSQRKVILKLIFKWKGSLWKAIYLDLIVWCFCYAFISVIYRYALDRSQQDTFERFMQFCNRRLDYIPINFMLGFFVTTVINRWMTQFANLGMIDNIALFTSMYLSGNDERGRILRRSIVRMCVMSQTMVFRDIHIGVRKRFPTLETMVAAGIMTSSELKKYNEVESRYAKYWLGFNWTFNLLNEARREGRIESAYTQNAIAEEIRTFRSGLSLIWTYDWVPIPLMYPQLVFMAIHCYYLVCLVSRQFVINSDAVNTTEIDLGVPFMTIIEFIFYMGWLKVAMDLLNPFGEDEDDFDCNFLIDRNLTVAMGIVDDSHDDGPILEKDMFWN 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-18 (Bestrophin homolog 18 [Source:UniProtKB/Swiss-Prot;Acc:P34577])

HSP 1 Score: 244.588 bits (623), Expect = 1.965e-75
Identity = 127/338 (37.57%), Postives = 199/338 (58.88%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQF-----ISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MT++Y  +VATS+ WTFL L+ RW+GS++  IW +  V+  LY  +S +YRF L    ++ F     +       +P+ ++LGF++  V+ R+W  +  I + D++A   +T+I G+ +++  YRR I+RY  L+  + F  +S KA++ FP L T+   G +   E+   +  + N  KYF+P  WA  LVY A  E +  G+  V  + E+I KFR  L  +  +DW+  P++Y  I  ++VH YF + + A Q+     I  D +D+  P    +QFVFYMGWLKV E L+NP+G+D DDFE + +I RN+ M   I+DE +D  P L+KD FW+
Sbjct:    1 MTVSYNQSVATSRPWTFLALIFRWRGSVWSAIWIQYSVWLGLYFLVSAIYRFILSAYQQQIFVRLVDYVNSRMSYVPLDWMLGFFIAGVLRRFWYLYDIIGFIDNIACSTATYIRGDSERAKQYRRNIIRYCELTQVLIFRDLSMKARKRFPTLDTVAAAGFMMPHEKANFDLIQYNYNKYFLPFNWAWALVYNARKEGLIEGDYYVTVISEDIKKFRTGLAWVCNYDWVPLPIIYPTIVCLAVHMYFFVGILARQYVKGSEIDPDMIDLVFPFMTSIQFVFYMGWLKVGEGLLNPWGEDPDDFETNMLIDRNLAMGLKIVDEGYDKTPRLEKDAFWD 338
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-3 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17206])

HSP 1 Score: 245.358 bits (625), Expect = 4.199e-74
Identity = 123/341 (36.07%), Postives = 206/341 (60.41%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFIS---------KDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFW 1148
            MT+TY   VA+S ++   +LL RWKGSI+K +W E++V+  LY  LS +YR  L    +  FE+ C F    ++ IP+ F+LGFYV+ V +RWW  F  I W D+  ++++ +I G  +++   RR  +RY  L+  M +  +++  ++ FP    L+  GL+T+ E        + +AKY+ P  W  +++  A  E M   +     L+E++ +FR ++  +  FDW+  PLVYTQ+  ++V +YF+I +F  Q++          K  +D+YVP+   LQF+F++GW+KVAE L+NP G+DDDDFE + ++ RN+++  +++D  ++ YP L+KD FW
Sbjct:    1 MTVTYSLDVASSSFFCLYKLLFRWKGSIWKSVWAELVVWLCLYAVLSVIYRCLLTMKQRATFEDLCIFFDTYSNFIPITFMLGFYVSAVFTRWWQIFDNIGWIDTPCLWITQYIKGETERAKCVRRNCIRYSILTQAMVYRDVAASVRKRFPTFNHLVTAGLMTEKEMAEFESIPSPHAKYWQPMHWLFSMITLARDEGMISSDIIYVDLMEKMRQFRVNILSLTLFDWVPVPLVYTQVVHLAVRSYFLIALFGRQYLHPESNRLNDFKQTIDLYVPIMSLLQFIFFIGWMKVAEVLLNPLGEDDDDFECNWILDRNLQVGLMVVDTAYNRYPTLEKDQFW 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-2 (Bestrophin homolog 2 [Source:UniProtKB/Swiss-Prot;Acc:Q17529])

HSP 1 Score: 239.195 bits (609), Expect = 9.793e-74
Identity = 128/343 (37.32%), Postives = 201/343 (58.60%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNN-----AKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISK-----DKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MTI Y   + TS  W F  LL RWKGSI+K I+ E I+F   Y  +S +YR  +    ++ FE    +  K    IP+ FVLGF+VT+VV RW   +  + + D + +  + ++ G  +K+++YRR I RY  L+  + F  +S + +R FP ++T++  G ++KDE  + N Y T N      KY++PA WA  + Y+A  +     +     +  EI  +R ++  +  +DW+  PL+Y Q+  ++V+ YF++ + A Q + +     D+VDVY P+  FLQF+FYMGWLKV E ++NPFG+DDDDFE + +I RNI M   ++D    + PEL KD F++
Sbjct:    1 MTINYHKEIKTSHTWKFFVLLFRWKGSIWKAIYMETIIFLICYGIISVVYRTAMSEPSQRTFESVIRYCDKRLSFIPLEFVLGFFVTIVVDRWTKLWRTVGFIDDVCLLANLYVRGTSEKAIIYRRNIARYCALTQLLVFRDVSMRTRRRFPTMETVVAAGFMSKDELDLYNSYTTKNNSRLGKKYWIPANWALCMTYKARKDGYIESDYFKAQMEGEIRTWRTNIEWVCNYDWVPLPLMYPQLVCLAVNLYFLVSIIARQLVIEKHKMVDEVDVYFPVMTFLQFIFYMGWLKVIEVMLNPFGEDDDDFETNALIDRNITMGLKMVDNTMKT-PELLKDQFFD 342
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183)

HSP 1 Score: 330.487 bits (846), Expect = 2.281e-105
Identity = 158/346 (45.66%), Postives = 239/346 (69.08%), Query Frame = 3 
Query:  153 MTITYINTVATSK-YWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKI---LNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISK---------DKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MTITY   VAT + +  FL+LLLRW+GSIYK++W +++ F T+Y  ++ +YRFGL    K+ FE    +     ++IP+ FVLGFYV++V++RWWNQ+  IPWPD +A++VS+ + G D++  M RRTIMRY+ L   M  A++S + K+ FP L  L+E GLL  +E+ I   +N+     +K+++P +WA++++ +A  E     +  V+T+I+E+ KFRG  G++  +D I+ PLVYTQ+ T++V++YF+     +Q+            +KVD+Y P+F  LQF FYMGWLKVAESLINPFG+DDDDFE++ M+ RN+++SYLI+DEMH  +PEL KD +W+
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020)

HSP 1 Score: 330.487 bits (846), Expect = 3.099e-105
Identity = 158/346 (45.66%), Postives = 239/346 (69.08%), Query Frame = 3 
Query:  153 MTITYINTVATSK-YWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKI---LNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISK---------DKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MTITY   VAT + +  FL+LLLRW+GSIYK++W +++ F T+Y  ++ +YRFGL    K+ FE    +     ++IP+ FVLGFYV++V++RWWNQ+  IPWPD +A++VS+ + G D++  M RRTIMRY+ L   M  A++S + K+ FP L  L+E GLL  +E+ I   +N+     +K+++P +WA++++ +A  E     +  V+T+I+E+ KFRG  G++  +D I+ PLVYTQ+ T++V++YF+     +Q+            +KVD+Y P+F  LQF FYMGWLKVAESLINPFG+DDDDFE++ M+ RN+++SYLI+DEMH  +PEL KD +W+
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590)

HSP 1 Score: 330.487 bits (846), Expect = 7.455e-105
Identity = 158/346 (45.66%), Postives = 239/346 (69.08%), Query Frame = 3 
Query:  153 MTITYINTVATSK-YWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKI---LNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISK---------DKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MTITY   VAT + +  FL+LLLRW+GSIYK++W +++ F T+Y  ++ +YRFGL    K+ FE    +     ++IP+ FVLGFYV++V++RWWNQ+  IPWPD +A++VS+ + G D++  M RRTIMRY+ L   M  A++S + K+ FP L  L+E GLL  +E+ I   +N+     +K+++P +WA++++ +A  E     +  V+T+I+E+ KFRG  G++  +D I+ PLVYTQ+ T++V++YF+     +Q+            +KVD+Y P+F  LQF FYMGWLKVAESLINPFG+DDDDFE++ M+ RN+++SYLI+DEMH  +PEL KD +W+
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0306023)

HSP 1 Score: 330.487 bits (846), Expect = 9.844e-105
Identity = 158/346 (45.66%), Postives = 239/346 (69.08%), Query Frame = 3 
Query:  153 MTITYINTVATSK-YWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKI---LNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISK---------DKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MTITY   VAT + +  FL+LLLRW+GSIYK++W +++ F T+Y  ++ +YRFGL    K+ FE    +     ++IP+ FVLGFYV++V++RWWNQ+  IPWPD +A++VS+ + G D++  M RRTIMRY+ L   M  A++S + K+ FP L  L+E GLL  +E+ I   +N+     +K+++P +WA++++ +A  E     +  V+T+I+E+ KFRG  G++  +D I+ PLVYTQ+ T++V++YF+     +Q+            +KVD+Y P+F  LQF FYMGWLKVAESLINPFG+DDDDFE++ M+ RN+++SYLI+DEMH  +PEL KD +W+
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKDQYWD 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best4 (gene:FBgn0036491 transcript:FBtr0113172)

HSP 1 Score: 296.975 bits (759), Expect = 1.294e-94
Identity = 149/342 (43.57%), Postives = 230/342 (67.25%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWT-FLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYET---NNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKD------KVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFW 1148
            MT+TY + V+TS   + FL LL+RW+GSIYK+IW ++IVF  LY  L+  YR  +    K+ FE   ++ +KN  +IP+ FVLGF+V +V++RWW+Q+  IPWPD +AI +ST I G+DD++ + RRTI+RY+ L   + F  IS + KR FP    +IE G L ++E+KI+   +    +  K+++P +WA+++V +A  E     +  V+T+I+E+ + RG+ G +  +DWI+ PLVYTQ+ T++ +++F+  V  +Q+          ++  + P+   LQF FYMGWLKVAE+LINPFG+DDDDFE++ +I RN+ +SY I+DEMH  +PEL KD +W
Sbjct:    1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQWNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHPELVKDQYW 342
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 285.034 bits (728), Expect = 4.621e-92
Identity = 140/336 (41.67%), Postives = 215/336 (63.99%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFI----SKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFW 1148
            MT++Y   VA +K+  F +LL RWKGSIYK+++ E +VF  LYT +S LYR  L    ++ F        K A +IP+ FVLGFYVT    RWW Q+   P PD++ + VS  + G D++  + RRT+MRY NLS  +   SIS++ ++ F  L+ ++E G +T DE + LN   ++  KY++P  W +NL  QA  E     +  +  L++E+  +R    M++ +DWI+ PLVYTQ+ T++V+++F   +   QF+    S++ +D+Y+P+F  L+F FY GWLKV E +INPFG+DDDDFE +++I RNI++S L +D+MH + P L+KD +W
Sbjct:    1 MTVSYTLKVANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLPPLEKDKYW 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 291.967 bits (746), Expect = 5.623e-91
Identity = 141/339 (41.59%), Postives = 221/339 (65.19%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MT+TY   VA ++  TF RLLLRWKGSIYK+++ E+++F  +Y  +S  YR  L    ++ FE+   +  + A +IPV FVLGFYVTLVVSRWW QF  +PWPD ++  VS  + G D+ + + RR++MRY NLS  + + S+S+   + FP +  L++ GL+T +E + L E  + + K++VP +W  +L  +A SE     +  +  ++ E+   R     +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF+   +      +D Y+P+F  LQF FY+GWLKVAE LINPFG+DDDDFE + ++ RN+++S L +DEM+D  P +++D +W+
Sbjct:    1 MTVTYSRRVADARLGTFYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADEGARLIRRSLMRYANLSGILIYRSVSTAVYKRFPTMSHLVQAGLMTAEELRQLQELPSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERDKYWD 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 279.641 bits (714), Expect = 7.039e-89
Identity = 139/343 (40.52%), Postives = 217/343 (63.27%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLG--FYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY   VA +++  F +LLL WKGSIYK+++ E + F  +YT +S  YRF L    K+ FE+   +    A +IP+ FVLG  FYVTLVV+RWW+Q+  IP PD +   +S  + G+D++  + RRT+MRY +LS  +   S+S+   + FP +  ++E G +T++E K      +   KY++P +W +NL   A  E     +   + L+EE+  FRG   M++ +D I+ PLVYTQ+ T++V+++F++ +   QF+   +      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S + +DEM+   P +++D +WN +
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPGQGYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPMMERDRYWNDS 343
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 261.922 bits (668), Expect = 1.945e-83
Identity = 131/318 (41.19%), Postives = 201/318 (63.21%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFI----SKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYL 1094
            MT++Y   VA +K+  F +LL RWKGSIYK+++ E +VF  LYT +S LYR  L    ++ F        K A +IP+ FVLGFYVT    RWW Q+   P PD++ + VS  + G D++  + RRT+MRY NLS  +   SIS++ ++ F  L+ ++E G +T DE + LN   ++  KY++P  W +NL  QA  E     +  +  L++E+  +R    M++ +DWI+ PLVYTQ+ T++V+++F   +   QF+    S++ +D+Y+P+F  L+F FY GWLKV E +INPFG+DDDDFE +++I RNI++  L
Sbjct:    1 MTVSYTLKVANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVCRL 318
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 166.392 bits (420), Expect = 5.553e-48
Identity = 81/212 (38.21%), Postives = 127/212 (59.91%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIE 788
            MT+TY   VA +++  F +LLL WKGSIYK+++ E + F  +YT +S  YRF L    K+ FE+   +    A +IP+ FVLGFYVTLVV+RWW+Q+  IP PD +   +S  + G+D++  + RRT+MRY +LS  +   S+S+   + FP +  ++E G +T++E K      +   KY++P +W +NL   A  E     +   + L+E
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLE 212
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: ifitm3 (interferon induced transmembrane protein 3 [Source:Xenbase;Acc:XB-GENE-5852510])

HSP 1 Score: 310.457 bits (794), Expect = 4.515e-98
Identity = 146/341 (42.82%), Postives = 229/341 (67.16%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + ++ F RLLL+W+GSIYK+++ E ++F +LYT LS +YRF L    K+ FE+   +  K A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD +   +S+ + G D+   + RRT+MRY+NL+  + F S+S+   + FP +  ++E G +T DE K+ +  ++ + KY+VP +W  NL  +A SE        ++ ++ E+ KFR    +++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   +      +D+Y+P+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S + +DEMH + P++++D++WN +
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFLLFTSLYTTLSVIYRFFLTDSQKRYFEKVSMYCDKYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSNVHGRDEYGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTSDERKLFDSLKSPHLKYWVPVIWFGNLASKARSEGRIRDSIDLQMMMNEMNKFRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPKQAYPGHDLDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLMAVDEMHMNLPKMNRDIYWNDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 300.827 bits (769), Expect = 1.165e-97
Identity = 154/368 (41.85%), Postives = 230/368 (62.50%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKS--PKNDMFAGSLLNLN 1232
            MT+TY N VA ++  TF RLLLRW+GSIYK+++ E ++F + Y  +S  YRF L    +  FE+   +    A++IPV FVLGFYVTLVVSRWW Q+  +PWPD +   VS+ + G D++  M RRT+MRY NL+  +   S+S+     FP L+ ++  G +T  E    +   +++ K++VP +W +NL   A SE        ++ +++E+   R   G +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF+   K      +D+YVP+F  LQF FY GWLKVAE LINPFG DDDDFE + +I RN+++S L +DEMH   P L+KD++WN + D Q  +   +   +   + GSLL+ N
Sbjct:    1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWN-DSDPQPPYTASTVETRRPSYQGSLLSGN 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 298.516 bits (763), Expect = 1.039e-96
Identity = 147/341 (43.11%), Postives = 218/341 (63.93%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY N VA ++  TF RLLLRW+GSIYK+++ E ++F + Y  +S  YRF L    +  FE+   +    A++IPV FVLGFYVTLVVSRWW Q+  +PWPD +   VS+ + G D++  M RRT+MRY NL+  +   S+S+     FP L+ ++  G +T  E    +   +++ K++VP +W +NL   A SE        ++ +++E+   R   G +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF+   K      +D+YVP+F  LQF FY GWLKVAE LINPFG DDDDFE + +I RN+++S L +DEMH   P L+KD++WN +
Sbjct:    1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWNDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 299.671 bits (766), Expect = 2.208e-96
Identity = 147/341 (43.11%), Postives = 218/341 (63.93%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY N VA ++  TF RLLLRW+GSIYK+++ E ++F + Y  +S  YRF L    +  FE+   +    A++IPV FVLGFYVTLVVSRWW Q+  +PWPD +   VS+ + G D++  M RRT+MRY NL+  +   S+S+     FP L+ ++  G +T  E    +   +++ K++VP +W +NL   A SE        ++ +++E+   R   G +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF+   K      +D+YVP+F  LQF FY GWLKVAE LINPFG DDDDFE + +I RN+++S L +DEMH   P L+KD++WN +
Sbjct:    1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWNDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 298.516 bits (763), Expect = 2.608e-96
Identity = 147/341 (43.11%), Postives = 218/341 (63.93%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY N VA ++  TF RLLLRW+GSIYK+++ E ++F + Y  +S  YRF L    +  FE+   +    A++IPV FVLGFYVTLVVSRWW Q+  +PWPD +   VS+ + G D++  M RRT+MRY NL+  +   S+S+     FP L+ ++  G +T  E    +   +++ K++VP +W +NL   A SE        ++ +++E+   R   G +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF+   K      +D+YVP+F  LQF FY GWLKVAE LINPFG DDDDFE + +I RN+++S L +DEMH   P L+KD++WN +
Sbjct:    1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDIYWNDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best3 (bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298])

HSP 1 Score: 314.309 bits (804), Expect = 1.312e-99
Identity = 149/341 (43.70%), Postives = 230/341 (67.45%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + ++ F RLLL+W+GSIYK+++ E IVFA LYT +S +YR  L G  K+ FE+   +  + A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD + + +S+ + G+D    + RRT+MRY+NL+  + F S+S+   + FP +  ++E G +T DE K+ +  ++ + KY+VP +W  NL  +A +E        +++L+ E+ ++R    +++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   K      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S L +DEMH S P++ KD++W+ +
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 300.827 bits (769), Expect = 3.003e-96
Identity = 149/340 (43.82%), Postives = 220/340 (64.71%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F  LY  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV RWWNQ++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W S+L  QA  E        ++ L+EE+  FR   GM++ +DWI+ PLVYTQ+ TI+V++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 300.827 bits (769), Expect = 3.003e-96
Identity = 149/340 (43.82%), Postives = 220/340 (64.71%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F  LY  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV RWWNQ++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W S+L  QA  E        ++ L+EE+  FR   GM++ +DWI+ PLVYTQ+ TI+V++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 300.827 bits (769), Expect = 3.003e-96
Identity = 149/340 (43.82%), Postives = 220/340 (64.71%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F  LY  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV RWWNQ++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W S+L  QA  E        ++ L+EE+  FR   GM++ +DWI+ PLVYTQ+ TI+V++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 278.485 bits (711), Expect = 1.331e-88
Identity = 142/339 (41.89%), Postives = 215/339 (63.42%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MTITY N VA ++  +F  LLL W+GSIYK+++ E +VF  LY  +  LYR  L    +  FE+   +      +IP+ FVLGFYVTLVVSRWW+Q+  +PWPD + I VS+F+ G D++  + RRT++RY  L   +   SIS+   + FP L  L+  G +T  E K L +    +  ++VP +W +NL  +A           +++L+ E+   R   G +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF++ +K      +D+ VP+F  LQF+FYMGWLKVAE LINPFG+DDDDFE + +I RN+++S L +D MH + P +++D++WN
Sbjct:    1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPPMERDMYWN 339
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8N1M1|BEST3_HUMAN (Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1 SV=1)

HSP 1 Score: 316.62 bits (810), Expect = 1.275e-99
Identity = 149/341 (43.70%), Postives = 231/341 (67.74%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + ++ F RLLL+W+GSIYK+++ E IVFA LYT +S +YR  L G+ K+ FE+   +  + A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD +   +S+ + G+D+   + RRT+MRY+NL+  + F S+S+   + FP +  ++E G +T DE K+ N  ++ + KY+VP +W  NL  +A +E        +++L+ E+ ++R    +++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   K      +D+Y+P+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S L +DEMH S P++ KD++W+ +
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS 341
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q6H1V1|BEST3_MOUSE (Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=2 SV=1)

HSP 1 Score: 314.309 bits (804), Expect = 9.177e-99
Identity = 149/341 (43.70%), Postives = 230/341 (67.45%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + ++ F RLLL+W+GSIYK+++ E IVFA LYT +S +YR  L G  K+ FE+   +  + A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD + + +S+ + G+D    + RRT+MRY+NL+  + F S+S+   + FP +  ++E G +T DE K+ +  ++ + KY+VP +W  NL  +A +E        +++L+ E+ ++R    +++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   K      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S L +DEMH S P++ KD++W+ +
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYVGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDS 341
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU1|BEST2_HUMAN (Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1 SV=1)

HSP 1 Score: 301.212 bits (770), Expect = 1.516e-95
Identity = 148/340 (43.53%), Postives = 221/340 (65.00%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F   Y  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV+RWW+Q++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W SNL  QA  E        ++ L+EE+  FRG  GM++ +DWI+ PLVYTQ+ TI++++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8BGM5|BEST2_MOUSE (Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=2 SV=1)

HSP 1 Score: 301.212 bits (770), Expect = 1.539e-95
Identity = 149/340 (43.82%), Postives = 220/340 (64.71%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNS 1154
            MT+TY   VA +++  F +LLL W+GSIYK++W E++ F  LY  LS  YRF L    K+ FE+   +  + A +IPV FVLGFYVTLVV RWWNQ++ +P PD++   V+  + G DD+  +YRRT+MRY  LS  +   S+S+   + FP +  ++E G +T++E K      ++  KY+VP +W S+L  QA  E        ++ L+EE+  FR   GM++ +DWI+ PLVYTQ+ TI+V++YF+  +   QF+   +      +D+ VP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S L +DEM+D    L+KD++W++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDA 340
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU0|BEST4_HUMAN (Bestrophin-4 OS=Homo sapiens OX=9606 GN=BEST4 PE=2 SV=1)

HSP 1 Score: 277.715 bits (709), Expect = 8.831e-87
Identity = 134/357 (37.54%), Postives = 221/357 (61.90%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK---------------------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNR 1160
            MT++Y   VA +++  F  LLLRW+GSIYK+++ E ++F  LY  LS  YR  L    +  + +   +  ++AD+IP+ FVLGFYVTLVV+RWW+Q+  IP PD +   +S  + G D +  + RRT++RY NL+  +   S+S++  + FP ++ +++ G ++++E K     +++  KY+VP +W +NL  QA  +     +  +  L+EE+ K+R    M++ +DWI+ PLVYTQ+ TI+V+++F + +   QF+  +                       D+YVP+   LQF FY GWLKVAE +INPFG+DDDDFE +++I RN+++S L +DEM+ + P  +KD +W+ ++
Sbjct:    1 MTVSYTLKVAEARFGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQRGRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDFNKYWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPAPALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVSLLSVDEMYQNLPPAEKDQYWDEDQ 357
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A504Z0E6 (Bestrophin homolog OS=Fasciola gigantica OX=46835 GN=FGIG_05512 PE=3 SV=1)

HSP 1 Score: 379.407 bits (973), Expect = 9.117e-125
Identity = 188/381 (49.34%), Postives = 260/381 (68.24%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYE-TNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN-SNRDIQIIHDYKS----------PKNDMFAGSLLNLNTDE 1241
            MT++Y + VAT+ Y TFLRLL  WKGS+Y++IWFE+++F  +Y+ LS  YRF L G+ K  FE  C +  ++ +MIPVPFVLGFYV+LVV+RWW QF+ +PWPD +A+ ++ +  GND++    RRT+MRY NL++C+   +ISS+A+  FP  + L+  GL+T++E  +L + E T    YFVP +WA N+V QA  E     +R VE L EEI  FRG LG I+ +DWINPPLVYTQ+ATI V++YF+  +FA Q++   K      +D+YVP+FG L+F FY+GWLKVAESLINPFG+D DDFEI+ +I RN+ +SYLI+DEMH  +PEL +D FW  ++  +   +D+               D F GSL NLN  E
Sbjct:    1 MTVSYASIVATTTYSTFLRLLFLWKGSVYRLIWFELLIFTGIYSILSLTYRFLLTGMMKTYFEWLCLYCNQHNEMIPVPFVLGFYVSLVVTRWWEQFLSLPWPDQLALQMTAYCHGNDERPTRIRRTVMRYTNLAYCIALRAISSRARLRFPTAEHLVSAGLMTEEELDVLVKTEPTEYQLYFVPLVWALNIVSQARQEGHIRFDRAVEILTEEITSFRGKLGTIFAYDWINPPLVYTQMATIVVYSYFLACLFAWQYLDLSKGYPGYDIDIYVPVFGLLRFFFYIGWLKVAESLINPFGEDADDFEIEYLIERNLNVSYLIVDEMHHEHPELVRDAFWGTADFTLSKSNDFAEGDADTTTGGVGDGDKFTGSLANLNLTE 381
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4E0RID6 (Bestrophin homolog OS=Fasciola hepatica OX=6192 GN=D915_008570 PE=3 SV=1)

HSP 1 Score: 379.407 bits (973), Expect = 9.626e-125
Identity = 188/381 (49.34%), Postives = 261/381 (68.50%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYE-TNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN-SNRDIQIIHDYK----------SPKNDMFAGSLLNLNTDE 1241
            MT++Y + VAT+ Y TFLRLL  WKGS+Y++IWFE+++F  +Y+ LS  YRF L G+ K  FE  C +  ++ +MIPVPFVLGFYV+LVV+RWW QF+ +PWPD +A+ ++ +  GND++    RRT+MRY NL++C+   +ISS+A+  FP  + L+  GL+T++E  +L + E T    YFVP +WA N+V QA  E     +R VE L EEI  FRG LG I+ +DWINPPLVYTQ+ATI V++YF+  +FA Q++   K      +D+YVP+FG L+F FY+GWLKVAESLINPFG+D DDFEI+ +I RN+ +SYLI+DEMH  +PEL +D FW  ++  +   +D+           +   D F GSL NLN  E
Sbjct:    1 MTVSYASIVATTTYSTFLRLLFLWKGSVYRLIWFELLIFTGIYSILSLTYRFLLTGMMKTYFEWLCLYCNQHNEMIPVPFVLGFYVSLVVTRWWEQFLSLPWPDQLALQMTAYCHGNDERPTRIRRTVMRYTNLAYCIALRAISSRARLRFPTAEHLVSAGLMTEEELDVLVKTEPTEYQLYFVPLVWALNIVSQARQEGHIRFDRAVEILTEEITTFRGKLGTIFAYDWINPPLVYTQMATIVVYSYFLACLFAWQYLDLSKGYPGYDIDIYVPVFGLLRFFFYIGWLKVAESLINPFGEDADDFEIEYLIERNLNVSYLIVDEMHHEHPELVRDAFWGTADFTLSKSNDFAEGDAETTTGGAGDGDKFTGSLANLNVME 381
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: C1L441 (Bestrophin homolog OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 359.377 bits (921), Expect = 6.885e-117
Identity = 176/380 (46.32%), Postives = 253/380 (66.58%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNN-AKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDES-----FLGS 1256
            MT+TY + VAT+KYWTF+RLL  WKGS+Y+++WFE +VF  +Y+ LS  YRF L    K+ FE+ C +  +  + +PV FVLGFYV+L+V RWW QF+ +PWPD +A++++ F  GN ++    RR I+RY+NLS+C+   +ISS+A+  FP  + L+  GL+T++E  I    + +    YFVP +WA ++V +A  E     +R VE L +EI  FR  LG I+ +DW+NPPLVYTQ  TI+V+ YF   + A Q++   K      +D+YVP+FG L+F FY+GWLKVAESLINPFG+D DDFEI+ +I RN+++SYLI+D MH  +P+L +D FWN+  DI ++ D+     D   G  +  N D S     F+GS
Sbjct:    1 MTVTYSSIVATAKYWTFIRLLFMWKGSVYRLVWFEFLVFVGIYSVLSVTYRFILSATLKRYFEQLCIYCGRYNETVPVAFVLGFYVSLIVQRWWEQFLSLPWPDRLALFITAFCHGNAERPTRIRRNIVRYINLSYCIALRAISSRARLRFPTEEHLVSAGLMTQEELDIYRSTQPSQYTLYFVPLVWALDMVTKAREEGYIHFDRAVEILTDEITSFRSKLGTIFAYDWVNPPLVYTQTVTIAVYGYFGTCLLAWQYLDPSKKYEGHEIDIYVPIFGLLRFFFYIGWLKVAESLINPFGEDVDDFEIEYLIERNLQVSYLIVDGMHHEHPDLVRDAFWNTT-DI-VLPDWTKMATD---GGSVEANVDASDTADKFIGS 375
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A3Q0KLS6 (Bestrophin homolog OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 359.377 bits (921), Expect = 7.190e-117
Identity = 178/385 (46.23%), Postives = 252/385 (65.45%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNN-AKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDY---------------KSPKNDMFAGSLLNLNTDE 1241
            MT+TY + VAT+KYWTF+RLL  WKGS+Y+++WFE +VF  +Y+ LS  YRF L    K+ FE  C +  +  + +PV FVLGFYV+L+V RWW QF+ +PWPD +A++++ F  GN ++    RR I+RY+NLS+C+   +ISS+A+  FP  + L+  GL+T++E  I    + +    YFVP +WA ++V +A  E     +R VE L  EI  FRG LG I+ +DW+NPPLVYTQ  TI+V+ YF   + A Q++   K      VD+YVP+FG L+F FY+GWLKVAESLINPFG+D DDFEI+ +I RN+++SYLI+D MH  +P+L +D +WN+  DI I+ D+                S   D F GSL N++  E
Sbjct:    1 MTVTYSSVVATAKYWTFIRLLFMWKGSVYRLVWFEFLVFVGIYSVLSVTYRFILSATLKRYFELLCIYCGRYNETVPVAFVLGFYVSLIVQRWWEQFLALPWPDRLALFITAFCHGNAERPTRIRRNIVRYINLSYCIALRAISSRARLRFPTEEHLVSAGLMTQEELDIYRSTQPSEYTLYFVPLVWALDMVTKAREEGYIRFDRAVEILTNEITSFRGKLGTIFAYDWVNPPLVYTQTVTIAVYGYFGTCLLAWQYLDPSKKYEGHDVDIYVPIFGLLRFFFYIGWLKVAESLINPFGEDVDDFEIEYLIERNLQVSYLIVDGMHHEHPDLVRDAYWNTT-DI-ILPDWTKMTTEGGAAEANLDASEGADKFVGSLANIDITE 383
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A2R2ML91 (Bestrophin homolog OS=Lingula unguis OX=7574 GN=LOC112041682 PE=3 SV=1)

HSP 1 Score: 348.977 bits (894), Expect = 6.332e-112
Identity = 165/339 (48.67%), Postives = 241/339 (71.09%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKD------KVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MT+TY   VATS + TF RLLLRWKGS+YK++W E+++F   Y  +S +YRF L   +K+ FE    + +   ++IP+ FVLGFYV++VV+RWW +FM IPWPD MA+YV+  I G+DD+  + RRTIMRY+ LSF MT  +IS+  K+ FP    L E GL T++E+KI+   +TNN+KYFVP +W ++++ +A  E     +  ++TL+EE+   RG LG +  +DWIN PL+YTQ+ T++V+ +F+  +   QF+         ++D Y+P+F  LQF+FYMGWLKVAESL+NPFG+DDDDFE++ +I RN++++YLI+DEMH  +P+L KD FW+
Sbjct:    1 MTVTYTAEVATSHFGTFWRLLLRWKGSVYKLLWVELLIFVVAYFTISFIYRFALPENHKRTFERISIYCELYNNLIPMAFVLGFYVSIVVTRWWEEFMSIPWPDKMALYVTANIHGHDDRGRLIRRTIMRYICLSFVMTARAISTAVKKRFPTDDHLTEAGLQTENEQKIIEGVKTNNSKYFVPLVWTTSIISRARKEGRIRDDFAMKTLVEELNFVRGQLGGLLNYDWINVPLIYTQVVTMAVYTFFLSCLMGRQFLDPQQGYDNHQIDFYIPIFTILQFIFYMGWLKVAESLLNPFGEDDDDFEMNWLIDRNLQVAYLIVDEMHSEHPDLIKDQFWD 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 300.056 bits (767), Expect = 9.584e-94
Identity = 144/341 (42.23%), Postives = 225/341 (65.98%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFI------SKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY   VA ++  TF  LLLRWKGSIYK+++ E+++F  LY  +S LYRF L    ++ FE+   +  + A +IPV FVLGFYVTLVVSRWW QF  +PWPD +A  V  ++ G D+ + + RR+++RY NLS  + + SIS+   + FP ++ L++ GL+T +E + L++  + + K++VP +W  NL  +A +E     +  +  ++ E+   R     +Y +DWI+ PLVYTQ+ T++V+++F+  +   QF+      S   +D Y+P+F  LQF FY+GWLKVAE LINPFG+DDDDFE + ++ RN+++S L +DEM+D  P +++D +WN +
Sbjct:    1 MTVTYSRRVADARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERDKYWNES 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 285.034 bits (728), Expect = 1.138e-88
Identity = 139/341 (40.76%), Postives = 219/341 (64.22%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY   VA +++  F +LLL W+GSIYK+++ E++ F  LYT +S  YRF L    K+ FE+   +    A +IP+ FVLGFYVTL+V+RWW+Q+  IP PDS+   +S  + G D++  + RRT+MRY +L+  +   S+S+   + FP +  ++E G +T++E K      +   KY++P +W +NL   A SE     +   + L+EE+ KFRG   +++ +D I+ PLVYTQ+ T++V+++F++ +   QF+   +      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S + +DEM    P +++D +WN +
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWRGSIYKVLYKEVLAFFILYTAISITYRFFLLDEQKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQGGDERGRLLRRTLMRYASLASLLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQAYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMFGDLPMMERDRYWNDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 263.462 bits (672), Expect = 1.106e-83
Identity = 139/363 (38.29%), Postives = 222/363 (61.16%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQ-IATISVHAYFMIFVFAEQFISKDK-------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGS 1217
            MT++Y   VA +++  F +LL RWKGSIYK+++ E ++F  LY+  S +YR  L    ++ FE       K A +IP+ FVL FYVT    RWW Q+   P PD++ + VS  + G+D++  + RRT+MRY NLS  +   SIS++  + FP L+ +++   +T++E + L+   ++  KY++P  W +NL  +A  E     +  +  L++E+  +RG   M++ +DWI+ PLVYTQ + T++V+++F   +   QF+  ++       VD+YVP+F  L+F FY GWLKV E +INPFG+DDDDFE +++I RNI++S L +D+MH + P L+KD +W      +      SP   +F GS
Sbjct:    1 MTVSYTLEVANARFAGFTKLLFRWKGSIYKLLYKEFLLFCFLYSLFSLIYRCVLTDGQQELFERAARHCNKFAKLIPMSFVL-FYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGSDERGRLLRRTLMRYANLSSVLILRSISTRVHKRFPTLQHIVD-AFMTEEEMRTLDHLYSDFNKYWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFVKPERADELKVHVDLYVPVFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLPPLEKDKYWTDKSFSRPF----SPAKPIFMGS 357
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 261.151 bits (666), Expect = 2.976e-79
Identity = 133/341 (39.00%), Postives = 210/341 (61.58%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFI------SKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY   VA ++  TF  LLLRWKGSIYK+++ E+++F  LY  +S LYRF L    ++ FE+   +  + A +IPV FVLGFYVTLVVSRWW QF  +PWPD +A  V  ++ G D+ + + RR+++RY NLS  + + SIS+   + FP ++ L++ GL+T +E + L++  + + K++VP +W  NL  +A +E                G+    + +    +          + T++V+++F+  +   QF+      S   +D Y+P+F  LQF FY+GWLKVAE LINPFG+DDDDFE + ++ RN+++S L +DEM+D  P +++D +WN +
Sbjct:    1 MTVTYSRRVADARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTE----------------GRINNDVALSAILN----------VVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERDKYWNES 315
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 150.984 bits (380), Expect = 3.435e-40
Identity = 79/208 (37.98%), Postives = 123/208 (59.13%), Query Frame = 3 
Query:  633 GLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTD 1238
            G +T +E+KI    ++ + KY++P +W +NL  +A  +        ++T++ E+ +FR     ++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   +      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE +  I RN+++S + +DEMH + P + KDV+WN   D  +   Y     D    S L   TD
Sbjct:   83 GFMTPEEKKIFENLKSPHLKYWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFLDPAQGYPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWCIDRNLQVSLMAVDEMHMNIPRMTKDVYWN---DPDVRPPYTRAAADYCIPSFLGSTTD 287

HSP 2 Score: 80.4925 bits (197), Expect = 6.321e-16
Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGF 404
            MT+TY + VA + ++ F RLLLRW+GSIYK+++ E + FA LY+ LS +YR+ L    ++ FE+   +  + A+ IPV FVLGF
Sbjct:    1 MTVTYSSKVANATFFGFHRLLLRWRGSIYKLLYREFLFFALLYSILSLVYRWVLTDPQRRLFEKLSIYCDRYAEQIPVTFVLGF 84
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 293.893 bits (751), Expect = 3.861e-96
Identity = 140/338 (41.42%), Postives = 220/338 (65.09%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKD-----KVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWN 1151
            MT+TY N VA ++   F +LLLRWKGSIYK+++ E  +F  L+  LS +YR+ L    K+ FE+   +  K A++IPV FVLGFYVTLVVSRWW+Q+  +PWPD +   V+  + G D++  + RRT+MRY NLS  +   S+S+   + FP +  ++E G +T  E +  +   + + K++VP +W +NL  QA++E   +    ++ ++ ++  FR    M+Y +DW++ PLVYTQ+ T++V+++F+  +   QF+         +D+Y+P+F  LQF FY GWLKVAE LINPFG+DDDDFE +  + RN+++S + +DEM+   P L+ DV+W+
Sbjct:    1 MTVTYSNKVANARLGGFSQLLLRWKGSIYKLLYKEFCIFLVLFFTLSSVYRYMLQENQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDRLMHLVACNVHGADERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTPAERRKFDGLRSPHNKFWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQFLGPQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEANWCVDRNLQVSLMGVDEMYRDLPPLEHDVYWD 338
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 292.738 bits (748), Expect = 7.651e-94
Identity = 148/374 (39.57%), Postives = 233/374 (62.30%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGS 1256
            MT+TY N VA ++   F +LLL+W+GSIYK+++ E  ++  +Y  LS   RF L    K+ FE+   +    A++IPV    GFYV LVVSRWW+Q+  IP PD +   V+  + G D++  + RRT+MRY NLS  +   S+S+   + FP +  ++E G +T+DE K  +    +  KY+VP +W S+L  QA +E     +  ++ L++E+  +RG+ GM++ +DWI+ PLVYTQ+ T++V+++F+  +   QF+   +      +D+Y+P+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN+++S L +DEM+ + P L +D++WN++           P+    A ++  L+   SFLGS
Sbjct:    1 MTVTYTNRVANARLCGFSKLLLQWRGSIYKLLYREFSIYFMMYAALSLTSRFALSEDQKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIPTPDRLMCAVAGTVHGVDERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTRDERKRFDGLRCSYNKYWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPAQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNLQVSMLAVDEMYQNLPLLQRDMYWNAS----------DPRPPYTAATMSTLHK-PSFLGS 363
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121])

HSP 1 Score: 306.22 bits (783), Expect = 7.567e-97
Identity = 145/341 (42.52%), Postives = 224/341 (65.69%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+TY + VA + + +F RLLLRW+GSIYK+++ E ++FA LYT LS +YR  L    K+ FE+   +  + A+ IPV FVLGFYVTLVV+RWWNQF+ +PWPD +  ++S+ + G D+   + RRT++RY+NL+  + F S+S+   + FP +  ++E G +T +E K+     + + KY++P +W SNL  +A  E        ++ ++ E+  FR     ++ +DW+  PLVYTQ+ T++V+ +F   +   QF+   +      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN+++S L +DEMH + P + KD++WN +
Sbjct:    1 MTVTYSSKVANATFLSFHRLLLRWRGSIYKLLYREFLLFALLYTILSLIYRLALSEQQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISSCVQGKDEYGRLLRRTLVRYINLTSLLIFRSVSTAVCKRFPTIDHVVEAGFMTPEERKVFENIRSPHLKYWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPAQGHPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWIIDRNLQVSLLAVDEMHMNLPHMTKDIYWNDS 341
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962])

HSP 1 Score: 288.5 bits (737), Expect = 1.744e-90
Identity = 146/374 (39.04%), Postives = 229/374 (61.23%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGS 1256
            MT+TY   VA +++  F +LLL WKGSIYK+++ E + F  LY  +S  YRF LY   K+ FE+   +    A +IP+ FVLGFYVTL+V+RWWNQ+  IP PD +   +S  + GND++  + RR++MRY +LS  +   S+S+   + FP +  ++E G +T++E K      +   KY++P +W +NL   A  E     +  ++ L+EE+  FRG   +++ +D ++ PLVYTQ+ T++V+++F++ +   QF+   +      +D+YVP+F  LQF FY GWLKVAE LINPFG+DDDDFE + +I RN ++S + +DEM+   P +++D +WN +          +P+    A +L  L    SF GS
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFVLYAAISITYRFFLYEDQKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQGNDERGRLLRRSMMRYASLSALLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFEGLHSPYNKYWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQGYQGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPVMERDRYWNDS----------NPRPPYTAATLFGLR-KPSFQGS 363
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866])

HSP 1 Score: 282.722 bits (722), Expect = 2.696e-87
Identity = 154/371 (41.51%), Postives = 232/371 (62.53%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSP--KNDMFAGSLLNLNTDE 1241
            MT+TY   VA +   TF  LLLRWKGSIYK+++ E+I+F  LY  LS +Y + L    ++ FE    +  + A++IPV FVL FYVTLVVSRWW QF  IPWPD +A  V   + G D+ S + RR +MRY+NLS  + + S+S+   + FP  + L++  L+T +E +   E  + + K++VP +W  NL  +A +E     +  +  ++ E+   R     +Y +DWI+ PLVYTQ+AT++V+++F+  +   QF+   +      VD Y+P+F  LQF FY+GWLKVAE LINPFG+DDDDFE + ++ RN+++S L +DEM+DS P ++KDV+WN + + Q  +   S   +   F GS L++   E
Sbjct:    1 MTVTYSRRVADAGLGTFFHLLLRWKGSIYKLLYRELIIFTLLYYFLSLVY-YMLDNDQRRLFERLSIYCDRYAELIPVSFVL-FYVTLVVSRWWGQFENIPWPDRLAALVGGHVRGTDEASRLTRRALMRYVNLSGVLIYRSVSTAVYKRFPTTEHLVQ-ALMTSEELRHFEELPSPHNKFWVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFLDPAQGYPGHDVDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWVVDRNLQVSLLSVDEMYDSLPLVEKDVYWN-DSEPQPPYTAASAEHRKPSFMGSALDIVPKE 367
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: ENSORLT00000038739.1 (pep primary_assembly:ASM223467v1:17:3718460:3718690:1 gene:ENSORLG00000029279.1 transcript:ENSORLT00000038739.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.9878 bits (123), Expect = 1.746e-8
Identity = 23/60 (38.33%), Postives = 39/60 (65.00%), Query Frame = 3 
Query:  480 VSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEK 659
            VS  + G D++  + RRT+MRY NLS  +   SIS++ ++ FP L+ ++E G + ++ EK
Sbjct:    4 VSGNVHGADERGRLLRRTLMRYANLSSVLILRSISTRVRKRFPTLEHVVEAGKIHRETEK 63
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000054993.1 (SMESG000054993.1)

HSP 1 Score: 790.03 bits (2039), Expect = 0.000e+0
Identity = 402/402 (100.00%), Postives = 402/402 (100.00%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGSKXXXXXXXXXXXXHRLSLSKHRDNILIENDLRNP 1358
            MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGDDDDDFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGSKINIFQNNIFSSIHRLSLSKHRDNILIENDLRNP
Sbjct:    1 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGDDDDDFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLNTDESFLGSKINIFQNNIFSSIHRLSLSKHRDNILIENDLRNP 402
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000069980.1 (SMESG000069980.1)

HSP 1 Score: 324.709 bits (831), Expect = 1.280e-107
Identity = 163/338 (48.22%), Postives = 236/338 (69.82%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFI------SKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFW 1148
            MT++Y++ +ATS  +   +LLL WKGSIYK I  E+ ++  L   +S L+ F L G Y+  FE FC+F  K    IPV  VLGFYVTLVV RW +QF+ +PWPDS+A+YV+TFILG  D   + RR+IMRY+ +S  + ++SISSKAKR+F   +TL+E GLLT +E   L ++ET + K+FVP  WA  LV +A+ EK  +  + V  L  E+ +FR  L +++ +DWINPPL+YTQIA I++++YF+  +F +QFI      S   +++YVP+FG L+F+ YMGWLKVA+ LINPFGDD+DDFE+D++I RN + S++ +D+ H   P L +D+++
Sbjct:    1 MTVSYVSKIATSNSFRVFKLLLTWKGSIYKTIRIELFIYIVLNALISLLHYF-LTGYYRLIFESFCSFCAKGTGFIPVGLVLGFYVTLVVQRWTDQFVTLPWPDSLAVYVNTFILGAGDTPRLIRRSIMRYVIVSQILCYSSISSKAKRVFSTNQTLVEQGLLTTEELSRLEKFETTSNKHFVPIAWAQELVVKAQKEKYLMDNKRVWLLANELNEFRDRLRILFAYDWINPPLIYTQIAIITMYSYFIFSIFGKQFIIHGTSQSAHGMNLYVPVFGALEFINYMGWLKVAQCLINPFGDDEDDFEMDQIILRNFEYSFITVDQWHQQCPPLQQDMYY 337
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000045575.1 (SMESG000045575.1)

HSP 1 Score: 298.516 bits (763), Expect = 1.714e-97
Identity = 154/346 (44.51%), Postives = 222/346 (64.16%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQI 1172
            MT+ Y   +A+SK + F+++L  WKGSIYKI WFE+I F +LY  +S +YRF LYG YK+ FE FC F     + IPV F++GFYVT++  RWW QF  IPWPD++A+ V+ +I G+D ++VM RR I+RY+NLS  +   SIS + K++  + + LI   L   +E K+ ++  ++  +YF+P LW+ NLV +   E     E     LI EI  +R  L  ++C+DW+NPPLVYTQ ATISV+ YF+  +F++QF+   K       D YVP+F   Q  FY GWLKVAE+LINPFG+DDDDF+   +I+RN+   +  I      +P++ KD  WN +  ++I
Sbjct:    1 MTVDYNRRMASSKCFKFMQILFLWKGSIYKIAWFELIFFGSLYAIISLIYRFVLYGKYKENFEIFCIFCDSIDNYIPVAFIMGFYVTMIARRWWKQFYNIPWPDNVALLVNAYISGSDRRTVMIRRNIIRYINLSLILFLRSISPQTKKIIKEEEDLISYELFNSEEFKLFDKVSSSFNRYFIPILWSVNLVKKMFLEGRIKTEIRARNLIIEIIHYREKLNKLFCYDWVNPPLVYTQTATISVYIYFLTSLFSKQFLDPIKRYPNRHFDYYVPVFSIAQLFFYFGWLKVAEALINPFGEDDDDFDSIGLINRNLTSFFFFIRSKESLFPKIIKDKKWNESLPLKI 346
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000057100.1 (SMESG000057100.1)

HSP 1 Score: 295.434 bits (755), Expect = 1.440e-96
Identity = 144/338 (42.60%), Postives = 221/338 (65.38%), Query Frame = 3 
Query:  153 MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKR---FEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSN 1157
            MT+ Y  ++    +WT   +LLRWKGS++K++ FE ++F ++Y  LS +YRF L   + K    F   C +  +  + IPV FVLGFYV++V++ W  QF  +PWPD +A+ +S F+ G  D+ V+ RRTI+RY+N+   + F  IS    ++F  L+++ + GL+   E K L   + +  KY+VP +WA+NL+  A  + +   +R ++ L+E +  FRG L  ++   WI+PPLVYTQ+ATI+V+ YF+  + A QFIS  K D   P FG LQF+FY+GWLKVAE+L++PFG+ DDDF++  +I RN++M+YLI+D+MH   PE+ KDV+W   
Sbjct:    1 MTVIYSGSLGKVHFWTVFAILLRWKGSVFKLVRFEALIFFSIYGSLSLIYRFVLVPYHTKSEFVFSFMCQYCIEIMNRIPVAFVLGFYVSIVINWWSEQFKSLPWPDDIALQLSAFLQGETDEIVLLRRTIVRYVNMGMIIAFRGISKSTLKLFSTLESMKKAGLMNMSELKALQSIDRSYNKYYVPLVWAANLIRDARRKNLIKDDRQLDVLVETLTSFRGILCDLFVHQWISPPLVYTQVATITVYCYFLAALMAWQFIS-GKDDYIFPFFGMLQFLFYVGWLKVAENLLDPFGEKDDDFDMTFLIERNVQMAYLIVDDMHRDIPEIKKDVYWKDE 337
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000040095.1 (SMESG000040095.1)

HSP 1 Score: 281.182 bits (718), Expect = 4.106e-91
Identity = 140/336 (41.67%), Postives = 220/336 (65.48%), Query Frame = 3 
Query:  243 IIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQFISKDK------VDVYVPMFGFLQFVFYMGWLKVAESLINPFGXXXXXFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKNDMFAGSLLNLN 1232
            ++WFE+++F  LY+ +S +YR  L G+YK++FE FC +     + +P+ F+L FYVT++ +RWW QF  IPWPD +A++V+T+I GN  K VM +R ++RYLN+S  +   S+S + K+ FP   +L++  L  + E  + N+ +    +Y+VP +WASNL+ +A  +     E  +  +I EI +FR  L  ++ +DW+NPPLVYTQ ATI+V+ YF+  +F+ QF+  +K      +D YVP+F  +Q VFY GWLKVAE LINPFG+DDDDF+   +I RNI  +++ +  + + +P L KDVFW+    I+ +++YK   N  F GS++ L+
Sbjct:    1 MVWFELVLFGILYSSISIMYRNLLSGLYKEQFERFCIYCDSIGNFMPIAFILSFYVTMIANRWWEQFNIIPWPDHVALFVNTYIPGNSVKLVMLKRNVVRYLNISLLLYLRSVSPQTKKRFPTEASLMDARLFNETEFNLFNQIDPTYNRYYVPIIWASNLIKKAFIDGDIKTEGRLNNIILEISQFRERLIKLFSYDWVNPPLVYTQTATIAVYTYFVTSLFSRQFLDPNKGYRNHNIDFYVPVFFLIQLVFYFGWLKVAECLINPFGEDDDDFDCLGLIERNITANFIFVKPLIEPHPVLMKDVFWDVESPIK-LNNYKDDVN-FFVGSMVRLD 334
The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BEST32.632e-10343.70bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST32.655e-10043.70bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST23.158e-9643.53bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST23.158e-9643.53bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST23.158e-9643.53bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
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BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best-245.931e-7735.85Bestrophin homolog 24 [Source:UniProtKB/Swiss-Pro... [more]
best-76.821e-7636.87Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:Q... [more]
best-181.965e-7537.57Bestrophin homolog 18 [Source:UniProtKB/Swiss-Pro... [more]
best-34.199e-7436.07Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-29.793e-7437.32Bestrophin homolog 2 [Source:UniProtKB/Swiss-Prot... [more]
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BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best12.281e-10545.66gene:FBgn0040238 transcript:FBtr0082183[more]
Best13.099e-10545.66gene:FBgn0040238 transcript:FBtr0337020[more]
Best17.455e-10545.66gene:FBgn0040238 transcript:FBtr0114590[more]
Best19.844e-10545.66gene:FBgn0040238 transcript:FBtr0306023[more]
Best41.294e-9443.57gene:FBgn0036491 transcript:FBtr0113172[more]
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BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best44.621e-9241.67bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best15.623e-9141.59bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best27.039e-8940.52bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best41.945e-8341.19bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best25.553e-4838.21bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ifitm34.515e-9842.82interferon induced transmembrane protein 3 [Source... [more]
best11.165e-9741.85bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best11.039e-9643.11bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best12.208e-9643.11bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best12.608e-9643.11bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
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BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best31.312e-9943.70bestrophin 3 [Source:MGI Symbol;Acc:MGI:3580298][more]
Best23.003e-9643.82bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best23.003e-9643.82bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best23.003e-9643.82bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best11.331e-8841.89bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
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BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8N1M1|BEST3_HUMAN1.275e-9943.70Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1... [more]
sp|Q6H1V1|BEST3_MOUSE9.177e-9943.70Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=... [more]
sp|Q8NFU1|BEST2_HUMAN1.516e-9543.53Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1... [more]
sp|Q8BGM5|BEST2_MOUSE1.539e-9543.82Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=... [more]
sp|Q8NFU0|BEST4_HUMAN8.831e-8737.54Bestrophin-4 OS=Homo sapiens OX=9606 GN=BEST4 PE=2... [more]
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BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A504Z0E69.117e-12549.34Bestrophin homolog OS=Fasciola gigantica OX=46835 ... [more]
A0A4E0RID69.626e-12549.34Bestrophin homolog OS=Fasciola hepatica OX=6192 GN... [more]
C1L4416.885e-11746.32Bestrophin homolog OS=Schistosoma japonicum OX=618... [more]
A0A3Q0KLS67.190e-11746.23Bestrophin homolog OS=Schistosoma mansoni OX=6183 ... [more]
A0A2R2ML916.332e-11248.67Bestrophin homolog OS=Lingula unguis OX=7574 GN=LO... [more]
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BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best19.584e-9442.23bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
best21.138e-8840.76bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best41.106e-8338.29bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best12.976e-7939.00bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
BEST33.435e-4037.98bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
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BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best13.861e-9641.42bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best27.651e-9439.57bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
BEST37.567e-9742.52bestrophin 3 [Source:NCBI gene;Acc:101172121][more]
best21.744e-9039.04bestrophin 2 [Source:NCBI gene;Acc:110015962][more]
best12.696e-8741.51bestrophin-2 [Source:NCBI gene;Acc:101167866][more]
ENSORLT00000038739.11.746e-838.33pep primary_assembly:ASM223467v1:17:3718460:371869... [more]
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BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000054993.10.000e+0100.00SMESG000054993.1[more]
SMESG000069980.11.280e-10748.22SMESG000069980.1[more]
SMESG000045575.11.714e-9744.51SMESG000045575.1[more]
SMESG000057100.11.440e-9642.60SMESG000057100.1[more]
SMESG000040095.14.106e-9141.67SMESG000040095.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027686 ID=SMED30027686|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1460bp
CAAAATTTGTATTCTTCAAGTTACATTTACAATTATTATTATTCATTATT
ATATTATTATTTATTCACATTTTTAATTTCACTAAATAATATTTAATTTC
TTTAATTCTTTATTTGCAAAAATGAATTGTAGTTATTAAAATATATTTAA
TCATGACGATTACATATATTAATACTGTTGCAACATCAAAATATTGGACT
TTTCTAAGGTTATTGTTAAGGTGGAAAGGGAGTATTTATAAAATAATATG
GTTTGAGATGATTGTATTTGCAACTTTATATACTGGTTTGTCTTGCCTAT
ATCGATTTGGTTTATATGGAATTTATAAAAAGAGGTTCGAGGAGTTTTGT
GCTTTCAGTAAGAAAAATGCAGACATGATACCAGTGCCATTTGTTCTTGG
ATTTTATGTGACCCTAGTTGTCAGTCGGTGGTGGAATCAATTTATGGAGA
TTCCTTGGCCAGATAGTATGGCAATTTATGTCAGTACCTTTATACTTGGA
AACGATGATAAATCTGTCATGTATCGCCGTACAATTATGCGCTATTTGAA
TCTCAGCTTCTGTATGACGTTCGCTAGTATTTCCAGTAAAGCTAAGCGAA
TGTTTCCCGATCTTAAAACTCTCATTGAAAATGGACTATTAACGAAGGAT
GAAGAGAAGATTCTTAATGAATATGAGACTAATAATGCAAAATATTTCGT
TCCTGCTTTGTGGGCTTCTAATCTTGTGTACCAAGCAGAATCCGAGAAAA
TGACAATCGGAGAAAGGGGGGTCGAAACGCTAATTGAAGAAATTGGGAAA
TTCAGAGGTAGTCTAGGAATGATTTATTGTTTTGACTGGATAAATCCTCC
ATTGGTTTACACACAGATTGCAACTATATCAGTTCATGCTTATTTTATGA
TTTTTGTATTCGCTGAACAATTTATTTCTAAAGATAAGGTCGATGTTTAC
GTGCCGATGTTTGGATTTTTACAATTTGTATTTTATATGGGATGGTTAAA
GGTCGCAGAATCTCTCATAAATCCATTTGGAGATGATGATGATGATTTTG
AAATCGACGAAATGATCCATCGTAACATTAAGATGTCTTACTTGATCATA
GATGAGATGCATGATTCTTATCCCGAACTTGACAAAGACGTGTTCTGGAA
CTCAAATCGTGACATTCAAATCATTCACGATTATAAAAGCCCAAAAAATG
ATATGTTTGCAGGATCTTTATTGAATCTCAATACCGACGAATCATTCTTA
GGATCAAAGATTAATATTTTCCAAAATAATATATTCAGCTCAATTCATAG
ACTCAGTTTATCGAAACACAGAGATAATATCCTTATTGAAAACGATTTGA
GAAATCCTTGAAATTTTTGAATTTGAATATATTGTCTGATAAACCTCATT
TTTTTAGTCTGTTAGCATTTTTAGGTTTTATATTGTCATTTGGAAATATA
TTCTCTCTCG
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protein sequence of SMED30027686-orf-1

>SMED30027686-orf-1 ID=SMED30027686-orf-1|Name=SMED30027686-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=403bp
MTITYINTVATSKYWTFLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLY
RFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEI
PWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRM
FPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKM
TIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMI
FVFAEQFISKDKVDVYVPMFGFLQFVFYMGWLKVAESLINPFGDDDDDFE
IDEMIHRNIKMSYLIIDEMHDSYPELDKDVFWNSNRDIQIIHDYKSPKND
MFAGSLLNLNTDESFLGSKINIFQNNIFSSIHRLSLSKHRDNILIENDLR
NP*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000615Bestrophin
IPR021134Bestrophin/UPF0187
Vocabulary: molecular function
TermDefinition
GO:0005254chloride channel activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:1902476chloride transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021134Bestrophin/UPF0187PFAMPF01062Bestrophincoord: 9..310
e-value: 2.3E-92
score: 309.5
NoneNo IPR availablePANTHERPTHR10736:SF55BESTROPHIN 1, ISOFORM C-RELATEDcoord: 1..359
NoneNo IPR availableTMHMMTMhelixcoord: 265..282
NoneNo IPR availableTMHMMTMhelixcoord: 234..253
NoneNo IPR availableTMHMMTMhelixcoord: 75..94
NoneNo IPR availableTMHMMTMhelixcoord: 32..54
IPR000615BestrophinPANTHERPTHR10736BESTROPHINcoord: 1..359