cAMP-dependent protein kinase regulatory subunit

Overview


Name	cAMP-dependent protein kinase regulatory subunit
Smed ID	SMED30027644
Length (bp)	1858

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of cAMP-dependent protein kinase regulatory subunit (SMED30027644) t-SNE clustered cells

Violin plots show distribution of expression levels for cAMP-dependent protein kinase regulatory subunit (SMED30027644) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of cAMP-dependent protein kinase regulatory subunit (SMED30027644) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027644

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
parapharyngeal region	SMED30027644	SMESG000003135.1	SmedASXL_013305	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
pharynx	SMED30027644	SMESG000003135.1	dd_Smed_v4_14355_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30027644	SMESG000003135.1	dd_Smed_v4_14355_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30027644	SMESG000003135.1	dd_Smed_v4_14355_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30027644	SMESG000003135.1	dd_Smed_v4_14355_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30027644	SMESG000003135.1	dd_Smed_v4_14355_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30027644	SMESG000003135.1	dd_Smed_v6_14355_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 57.7658 bits (138), Expect = 4.640e-8
Identity = 55/194 (28.35%), Postives = 87/194 (44.85%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVAPVLEEEFKMKLE 619
            A + AI+ +    ++ E    I+ + ++ R E        +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV     EE +  LE
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE----QYRNFLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTF--EELQKYLE 402

HSP 2 Score: 53.1434 bits (126), Expect = 1.418e-6
Identity = 43/210 (20.48%), Postives = 88/210 (41.90%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   + +     +I +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +    +   +    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

[Close]

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVAPVLEEEFKMKLE 619
            A + AI+ +    ++ E    I+ + ++ R E        +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV     EE +  LE
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE----QYRNFLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTF--EELQKYLE 402

HSP 2 Score: 53.1434 bits (126), Expect = 1.418e-6
Identity = 43/210 (20.48%), Postives = 88/210 (41.90%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   + +     +I +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +    +   +    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 57.7658 bits (138), Expect = 4.847e-8
Identity = 55/194 (28.35%), Postives = 87/194 (44.85%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVAPVLEEEFKMKLE 619
            A + AI+ +    ++ E    I+ + ++ R E        +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV     EE +  LE
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE----QYRNFLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTF--EELQKYLE 402

HSP 2 Score: 53.1434 bits (126), Expect = 1.434e-6
Identity = 43/210 (20.48%), Postives = 88/210 (41.90%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   + +     +I +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +    +   +    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG1 (protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414])

HSP 1 Score: 51.9878 bits (123), Expect = 3.109e-6
Identity = 38/190 (20.00%), Postives = 78/190 (41.05%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +++C    ++  +  +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F    +    +L   +E    E    I++QG R    + +  G + ++ E
Sbjct:  130 IVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 286

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Match: PRKG1 (protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414])

HSP 1 Score: 51.2174 bits (121), Expect = 4.819e-6
Identity = 41/206 (19.90%), Postives = 84/206 (40.78%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            L +D ++ L       +++C    ++  +  +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F    +    +L   +E    E    I++QG R    + +  G + ++ E
Sbjct:   99 LDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 271

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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: egl-4 (cGMP-dependent protein kinase egl-4 [Source:UniProtKB/Swiss-Prot;Acc:O76360])

HSP 1 Score: 61.2326 bits (147), Expect = 1.795e-9
Identity = 45/205 (21.95%), Postives = 89/205 (43.41%), Query Frame = 2

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS F   S+    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  197 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVT 367

[Close]

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS F   S+    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  197 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVT 367

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: egl-4 (cGMP-dependent protein kinase egl-4 [Source:UniProtKB/Swiss-Prot;Acc:O76360])

HSP 1 Score: 60.8474 bits (146), Expect = 2.043e-9
Identity = 45/205 (21.95%), Postives = 89/205 (43.41%), Query Frame = 2

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS F   S+    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  154 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVT 324

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: egl-4 (cGMP-dependent protein kinase egl-4 [Source:UniProtKB/Swiss-Prot;Acc:O76360])

HSP 1 Score: 60.8474 bits (146), Expect = 2.043e-9
Identity = 45/205 (21.95%), Postives = 89/205 (43.41%), Query Frame = 2

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS F   S+    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  154 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVT 324

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Match: egl-4 (cGMP-dependent protein kinase egl-4 [Source:UniProtKB/Swiss-Prot;Acc:O76360])

HSP 1 Score: 60.8474 bits (146), Expect = 2.076e-9
Identity = 45/205 (21.95%), Postives = 89/205 (43.41%), Query Frame = 2

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS F   S+    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  166 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVT 336

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0446099)

HSP 1 Score: 63.5438 bits (153), Expect = 3.524e-10
Identity = 43/211 (20.38%), Postives = 92/211 (43.60%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQ 796
            L +D ++ L       +++C    K+P+  ++I EG++G  +Y++  GR+ V R                                  G+ L+TL    + GE+A++  C RTA++    EC +  I R+ +   +     + + E+    +F++SV  F   ++    ++   +E    +    I++QG R    + +  G++R++ + Q
Sbjct:  170 LDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSRE---------------------------------GKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYS---DFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ 344

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0473363)

HSP 1 Score: 63.5438 bits (153), Expect = 3.767e-10
Identity = 40/195 (20.51%), Postives = 86/195 (44.10%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQ 796
            +++C    K+P+  ++I EG++G  +Y++  GR+ V R                                  G+ L+TL    + GE+A++  C RTA++    EC +  I R+ +   +     + + E+    +F++SV  F   ++    ++   +E    +    I++QG R    + +  G++R++ + Q
Sbjct:   12 IVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSRE---------------------------------GKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYS---DFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ 170

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0473364)

HSP 1 Score: 63.5438 bits (153), Expect = 3.767e-10
Identity = 40/195 (20.51%), Postives = 86/195 (44.10%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQ 796
            +++C    K+P+  ++I EG++G  +Y++  GR+ V R                                  G+ L+TL    + GE+A++  C RTA++    EC +  I R+ +   +     + + E+    +F++SV  F   ++    ++   +E    +    I++QG R    + +  G++R++ + Q
Sbjct:   12 IVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSRE---------------------------------GKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYS---DFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ 170

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089310)

HSP 1 Score: 63.5438 bits (153), Expect = 5.023e-10
Identity = 43/211 (20.38%), Postives = 92/211 (43.60%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQ 796
            L +D ++ L       +++C    K+P+  ++I EG++G  +Y++  GR+ V R                                  G+ L+TL    + GE+A++  C RTA++    EC +  I R+ +   +     + + E+    +F++SV  F   ++    ++   +E    +    I++QG R    + +  G++R++ + Q
Sbjct:  516 LDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSRE---------------------------------GKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYS---DFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ 690

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089312)

HSP 1 Score: 63.5438 bits (153), Expect = 5.023e-10
Identity = 43/211 (20.38%), Postives = 92/211 (43.60%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQ 796
            L +D ++ L       +++C    K+P+  ++I EG++G  +Y++  GR+ V R                                  G+ L+TL    + GE+A++  C RTA++    EC +  I R+ +   +     + + E+    +F++SV  F   ++    ++   +E    +    I++QG R    + +  G++R++ + Q
Sbjct:  516 LDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSRE---------------------------------GKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYS---DFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ 690

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BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:ZDB-GENE-060531-80])

HSP 1 Score: 62.3882 bits (150), Expect = 1.120e-9
Identity = 46/210 (21.90%), Postives = 91/210 (43.33%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G+L V++ N                                 + L ++     FGE+A++  C RTASV      +   + RE+++N +    E   +    F+ SVS  A        +++  +E         I+++GE  +  Y + +G+I+++   Q H
Sbjct:  167 KNQYLRRLEVQQVKDMV-ECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHN---------------------------------KLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQDH 342

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:ZDB-GENE-060531-80])

HSP 1 Score: 62.003 bits (149), Expect = 1.510e-9
Identity = 46/210 (21.90%), Postives = 91/210 (43.33%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G+L V++ N                                 + L ++     FGE+A++  C RTASV      +   + RE+++N +    E   +    F+ SVS  A        +++  +E         I+++GE  +  Y + +G+I+++   Q H
Sbjct:  172 KNQYLRRLEVQQVKDMV-ECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHN---------------------------------KLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQDH 347

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:ZDB-GENE-060531-80])

HSP 1 Score: 62.003 bits (149), Expect = 1.585e-9
Identity = 46/210 (21.90%), Postives = 91/210 (43.33%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G+L V++ N                                 + L ++     FGE+A++  C RTASV      +   + RE+++N +    E   +    F+ SVS  A        +++  +E         I+++GE  +  Y + +G+I+++   Q H
Sbjct:  167 KNQYLRRLEVQQVKDMV-ECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHN---------------------------------KLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQDH 342

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:ZDB-GENE-060531-80])

HSP 1 Score: 59.6918 bits (143), Expect = 7.808e-9
Identity = 46/210 (21.90%), Postives = 93/210 (44.29%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G+L V++ N                                 + L ++     FGE+A++  C RTASV      +   + RE+++N +    E   +    F+ SVS  A        +++  +E +  +    I+++GE  +  Y + +G+I+++   Q H
Sbjct:  172 KNQYLRRLEVQQVKDMV-ECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHN---------------------------------KLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEEYYNK-GDYIIREGEEGNTFYIIANGKIKVTQSTQDH 346

HSP 2 Score: 51.6026 bits (122), Expect = 2.738e-6
Identity = 59/224 (26.34%), Postives = 99/224 (44.20%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEE-CEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYP 712
            A + A S +    ++ E    I+   ++ R E + R+   +LR  V     L  D L T +++C  E +     +I EGE G+  YI+ +G++ V +  +       ++EP                     Q + TL  G  FGE ALI   +R+A+++  E+  E +VI RE ++ TV     +E K  L+     S+    ++  KK+   A  S SC  P
Sbjct:  251 ASVKAASNVKTWALDREVFHNIMRMTAEARHE-QYRN---FLRS-VSLLASLPGDKL-TKIVDCLEEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQD------HEEP---------------------QIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVGTF--DELKKYLQ-----SYVDSLARDDKKR--NAKRSGSCTPP 432

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Match: prkg1a (protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:ZDB-GENE-040426-1308])

HSP 1 Score: 51.9878 bits (123), Expect = 2.059e-6
Identity = 38/190 (20.00%), Postives = 77/190 (40.53%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +++C     +  N  +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +E ++SV  F    +    +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:  111 IVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GLKLCTMGPGKVFGELAILYNCTRTATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTRE 267

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Match: bmp4 (bone morphogenetic protein 4 [Source:Xenbase;Acc:XB-GENE-483058])

HSP 1 Score: 63.1586 bits (152), Expect = 5.274e-10
Identity = 54/227 (23.79%), Postives = 97/227 (42.73%), Query Frame = 2

Query:   92 ETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPR-ELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSG 769
            E   E+  +  + R E +IR +   +   +  F++ S  +   L       ++   +V++ +G  GD  Y + SG + V        +DV  D    L  P    EP++            L  G  FGEVAL++   R A+VV  EE E +V+ R E + N +   L++E K + +   S+  F+  S +  + L    ++  C +   ++K       + F+  G
Sbjct:    7 EKAIEVALRRPEQRSEQDIRFIRSMMM-GILSFRRYSSQMQLMLARVVYYRRFGRGRVIVRKGHRGDSFYFVFSGVIAV-------TQDV--DGSSALLDP----EPIL------------LHKGASFGEVALLKDLRRNATVVCMEETEFLVVDRMEFFENKLDQELQKELKYRFQHFRSLDLFSSWSDKSLETLADHCKAEECHHSQVMVKDTHETKNIIFVTKG 207

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 53.5286 bits (127), Expect = 8.595e-7
Identity = 40/190 (21.05%), Postives = 80/190 (42.11%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +++C    ++  +  +I EG++G  +Y++  G++ V       KE V                            L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F    +    +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:  129 IVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVT------KESVK---------------------------LCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE 285

[Close]

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +++C    ++  +  +I EG++G  +Y++  G++ V       KE V                            L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F    +    +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:  129 IVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVT------KESVK---------------------------LCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE 285

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 53.5286 bits (127), Expect = 1.049e-6
Identity = 43/206 (20.87%), Postives = 86/206 (41.75%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            L +D ++ L       +++C    ++  +  +I EG++G  +Y++  G++ V       KE V                            L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F    +    +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:  101 LDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVT------KESVK---------------------------LCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTRE 273

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 58.5362 bits (140), Expect = 1.902e-8
Identity = 53/182 (29.12%), Postives = 85/182 (46.70%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVA 583
            A + AI+ +    ++ E    I+ + ++ R E E R+   +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV 
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE-EYRN---FLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG 392

HSP 2 Score: 53.9138 bits (128), Expect = 5.259e-7
Identity = 47/213 (22.07%), Postives = 92/213 (43.19%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   + +     VI +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +   A   +EE++    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYR---NFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 58.5362 bits (140), Expect = 1.934e-8
Identity = 53/182 (29.12%), Postives = 85/182 (46.70%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVA 583
            A + AI+ +    ++ E    I+ + ++ R E E R+   +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV 
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE-EYRN---FLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG 392

HSP 2 Score: 53.9138 bits (128), Expect = 5.291e-7
Identity = 47/213 (22.07%), Postives = 92/213 (43.19%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   + +     VI +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +   A   +EE++    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYR---NFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 52.373 bits (124), Expect = 1.767e-6
Identity = 38/190 (20.00%), Postives = 78/190 (41.05%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +++C    ++  +  +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F         +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:  130 IVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTRE 286

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 51.6026 bits (122), Expect = 2.578e-6
Identity = 41/206 (19.90%), Postives = 84/206 (40.78%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            L +D ++ L       +++C    ++  +  +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F         +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:   99 LDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTRE 271

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|Q03043|KGP24_DROME (cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster OX=7227 GN=for PE=1 SV=3)

HSP 1 Score: 63.5438 bits (153), Expect = 5.036e-9
Identity = 43/211 (20.38%), Postives = 92/211 (43.60%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQ 796
            L +D ++ L       +++C    K+P+  ++I EG++G  +Y++  GR+ V R                                  G+ L+TL    + GE+A++  C RTA++    EC +  I R+ +   +     + + E+    +F++SV  F   ++    ++   +E    +    I++QG R    + +  G++R++ + Q
Sbjct:  516 LDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSRE---------------------------------GKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYS---DFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQ 690

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|A8X6H1|EGL4_CAEBR (cGMP-dependent protein kinase egl-4 OS=Caenorhabditis briggsae OX=6238 GN=egl-4 PE=3 SV=2)

HSP 1 Score: 62.7734 bits (151), Expect = 6.268e-9
Identity = 45/205 (21.95%), Postives = 90/205 (43.90%), Query Frame = 2

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS FA  ++    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  166 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GATLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQIINFLSKVSIFANLTEDRISKIADVMDQDYYDGGHYILRQGEKGDAFFVINSGQVKVT 336

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|O76360|EGL4_CAEEL (cGMP-dependent protein kinase egl-4 OS=Caenorhabditis elegans OX=6239 GN=egl-4 PE=1 SV=2)

HSP 1 Score: 61.2326 bits (147), Expect = 2.284e-8
Identity = 45/205 (21.95%), Postives = 89/205 (43.41%), Query Frame = 2

Query:  173 EKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +K  + K+L+ + +  LV  C  E +  + + VI EGE GD ++++  G L V R                                  G  L  + +G + GE+A++  C RTASV    + ++ V+ R ++      +  E     + F+  VS F   S+    ++   ++    +    I++QGE+  A + + SG+++++
Sbjct:  197 QKNDFLKQLAKEQIIELV-NCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSRE---------------------------------GALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVT 367

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|Q64595|KGP2_RAT (cGMP-dependent protein kinase 2 OS=Rattus norvegicus OX=10116 GN=Prkg2 PE=1 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 1.139e-7
Identity = 53/182 (29.12%), Postives = 85/182 (46.70%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVA 583
            A + AI+ +    ++ E    I+ + ++ R E E R+   +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV 
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE-EYRN---FLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG 392

HSP 2 Score: 52.7582 bits (125), Expect = 8.156e-6
Identity = 45/213 (21.13%), Postives = 92/213 (43.19%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   + +     ++ +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +   A   +EE++    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGRNYQQGSYIVKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYR---NFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Match: sp|Q61410|KGP2_MOUSE (cGMP-dependent protein kinase 2 OS=Mus musculus OX=10090 GN=Prkg2 PE=1 SV=1)

HSP 1 Score: 58.5362 bits (140), Expect = 1.377e-7
Identity = 53/182 (29.12%), Postives = 85/182 (46.70%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIEC-TVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTE-ECEMVVIPRELYNNTVA 583
            A + AI+ +    ++ E    I+ + ++ R E E R+   +LR  V   K L +D L T +I+C  VE +     +I EGE G   +IL  G++ V +  E       +D+P                     Q + TL+ G  FGE ALI   +R+A+++  E +   +VI RE +N TV 
Sbjct:  244 ASVKAITNVKTWALDREVFQNIMRRTAQARDE-EYRN---FLRS-VSLLKNLPEDKL-TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE------GHDQP---------------------QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG 392

HSP 2 Score: 56.6102 bits (135), Expect = 5.355e-7
Identity = 49/213 (23.00%), Postives = 93/213 (43.66%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTV-EKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTV---APVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K ++ K+L    ++ +V EC   EK  +   VI +GE G+ +++L  GRL V                        + E L          L+++     FGE+A++  C RTASV      +   + RE++ N +   A   +EE++    F+ SVS      +    +++  +E    +    I+++GE  S  + L  G+++++   + H
Sbjct:  165 KNQFLKRLDPQQIKDMV-ECMYGEKLSTGSYVIKQGEPGNHIFVLAEGRLEV-----------------------FQGEKL----------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYR---NFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

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BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A1S3JNU3 (uncharacterized protein LOC106174696 OS=Lingula unguis OX=7574 GN=LOC106174696 PE=4 SV=1)

HSP 1 Score: 231.876 bits (590), Expect = 3.238e-64
Identity = 149/470 (31.70%), Postives = 253/470 (53.83%), Query Frame = 2

Query:   98 LAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALI-EKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHF----------QKTYNSWNQESYG-----KMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLGNV----LPLLGLIKDRTLYCMKNLKGYKGPLTLEQLLKRNQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLRE--QNKKYNRNKLFHQESFKPL 1441
            + E++SKP+ +R +FEI  +  W ++K + FK L  DIL  ++  C+  K   N+++I +G+ G+C +ILLSGR+ ++     +  D + +E  E        E ++ D   LG  + TL  G  FGEVAL+ E C+RTAS++  + C+M+VI R+LY  +V  VL +EF+ K +F+ +  FF     ++KKQL MA+E H+  Y + + KQG+ V+A+YF++ GE++LS +PQ H+  F          +K  ++   ++ G     K+++ +L ++   +KK+    K  D+C L       G    IGD+E+LL     + TA  T    +L L  RH++R+ +KR P +I  M +    RI+  C R+ +V    +P +  +  ++      ++  +   TL ++    +D+     PP  G LID + PGTVF  I+ + + R+  Q +  +R  L H  S   L
Sbjct:   10 VVEVISKPTSERKDFEIAPLLPWFKKKSELFKDLKSDILHDVIKHCSFVKNRQNQLIIRQGDKGECFFILLSGRVSIYIFYAKNM-DSSENESTEHESDVTDDEYIVRDRRKLGTYVTTLNPGATFGEVALVSEDCVRTASIICDDPCDMIVIDRDLYTRSVKSVLAQEFEDKAKFVSTNQFFGGWPPKYKKQLAMALEKHTLTYDSVLAKQGQPVNALYFILRGEVKLSMDPQLHSSMFPSSPTKVRAERKKEDANGTQTKGAPISRKLSRAVLQKKANPHKKKVEPRKLIDVCCL-------GPNECIGDIEVLLEYETFLQTAKCTQKTEILTLDMRHWDRLFVKRQPKTIEKMRQGLELRIQ--C-RITDVVEKHIPFMKQLLSKSKQYNIIIENTENSKTLSKMNPTKKDDAVDIVPP-WGPLIDQYAPGTVFHRIRAREHRRKLRQLRDEHRKSLEHPTSADEL 467

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A210QU71 (cAMP-dependent protein kinase regulatory subunit OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT04116 PE=4 SV=1)

HSP 1 Score: 219.164 bits (557), Expect = 3.145e-59
Identity = 149/459 (32.46%), Postives = 248/459 (54.03%), Query Frame = 2

Query:   74 MTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALI-EKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKTYNSWNQES------YGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLGNV--LPLLGLIKDRTLYCMKNLKGYKGPLTLEQLLKR---NQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNK-KYNRNK 1411
            M +   E +  ++SK  + R +FEI+ +  WLR+K + F +L  D L+ +V  C +  +   +++I +GE GDC YI+L G++ +  LN+    D  +   +E+     R      D S LG  +  L SG  FGEVAL+ + C+RTAS+++ E+ +++V+ R LYN  V  VL +EF+ K+EFI++   FA  + R++KQL MA+   +  Y + +++QG  V+ +YF++SG++ +  +P HH   + + +     ES      + ++     +Q     KK+ S  K   +C+L       G   SIG+VE+LL++P    TA  T    VLVL  +H+ER+ ++R+P +I  M  +   ++E     L N   LP L L+KDR       +  Y  P       K+   +     + F  +KG LIDI+GPG+VF+ I+    +RE++K KY  +K
Sbjct:    1 MGSTQYEKVVAVISKRPELRQDFEIQGLLLWLRKKSQLFSQLKTDYLKDIVRNCGMVSYDKEEMIIKQGERGDCFYIILDGKISIFILNKDKDADDDDRAMEEIGS---RTPEGKLDKSKLGNFVTHLGSGVPFGEVALMSDDCIRTASIISEEKTDLLVVDRALYNRAVKIVLAKEFEEKVEFIKTNPLFANWAPRYRKQLTMAMYKETLPYDSVLVRQGGPVTNIYFVISGQVEIQIDPSHHQVQYPRIFMEAQDESDRLIRKHERIRPPTEAQYSTFVKKKDST-KYSKLCIL-------GINESIGEVEVLLDLPTYTQTAVCTEKTDVLVLERKHYERLFVRRHPRTIEAMRGMFKVKLETRMNLLTNKEELPFLNLLKDR-------IDSYNNPKPSADKKKKELTSASAAEKEFLNHKGPLIDIYGPGSVFYMIR----VREKHKQKYKAHK 437

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: K1Q5I1 (cAMP-dependent protein kinase regulatory subunit OS=Crassostrea gigas OX=29159 GN=CGI_10006713 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 4.694e-50
Identity = 134/445 (30.11%), Postives = 236/445 (53.03%), Query Frame = 2

Query:   92 ETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALI-EKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKTYNSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDN--------GNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLGNV--LPLLGLIKDRTLYCMKNLKGYKGPLTLEQLLKRNQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNK 1393
            E +  ++SKP   R +FEI+++  WLR++ + F +L  + L+ ++  C    +  + ++I +G+ GDC Y++L G++ ++ LN+  +E    DE   L       E    D S LG  +  L +G  FG+VAL+ E C+RTA+++  E  +++V+ R LYN  V  VL +E++ K+ FI +   F+  + R+KKQL MA+      Y T ++KQG+ V  +YFL+ G + L  +P  H   + K Y     E      ++LL    +R+K +      ++     +K +++        G   S+G++E+LL M   + TA  T    VLVL  +H+ER+ +KR+  +I  M ++   ++E     L N   +P L  +K + L  M N +    P+  ++    ++    + F  +KG LID++GPG+VF+ I+    +RE+ K
Sbjct:    6 EKVLNVISKPPAFRQDFEIQTLMPWLRKQSQLFSQLRTEYLKDIIRNCGQVTFNKDDIIIKQGDQGDCFYMILGGKISIYVLNKKSEE---GDETVPLEQIGTLNEKGQLDRSKLGIFVTHLGTGVPFGDVALMSEDCVRTATIIAEEVTDLLVVDRALYNRAVKEVLAKEYEDKVAFINNNPLFSAWTPRYKKQLTMAMYKEEFTYNTTLVKQGDPVEVIYFLIRGHVELRTDPAMHPVQYPKIYLDTMNEG-----ERLL----RRDKVRPPTEPHYNNSTQLRKKENHKHVKMFLLGRNESVGELEILLGMDTYMQTAVCTEKVDVLVLEMKHYERLFVKRHQRTIEDMRKILEVKLETRMDLLANKSEIPFLPRVKTK-LNMMNNPQ----PVAKKEKELPSKKMAEREFLNHKGPLIDMYGPGSVFYMIR----VREKTK 429

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: V4BGQ9 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_227784 PE=4 SV=1)

HSP 1 Score: 177.948 bits (450), Expect = 6.817e-44
Identity = 130/518 (25.10%), Postives = 251/518 (48.46%), Query Frame = 2

Query:   41 LAFLCAI-STISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKI--RAEPLIE--DTSILGQCLATLESGHIFGEVALIEK-CMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHA----HHF-----------------------QKTYNSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLG-NVLPLLGLIKDRTLYCMKNLKGY----KGPLTLEQL---LKRNQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNKKYNRNKLFHQESFKPLQKSFYRSVGR 1471
            +  +C + ST        +T+  ++++P++ R + EI  +  W R+K   FK L  ++L+ ++  C       + V+I +GE GDC +I+L+G + +H       E+  N   ++L    +  R  P +   D S  G  L  +E+G  FGE+ALI   C+R AS+++TE  +++++ ++LYN ++     + F+ K +F+ S+  F     R+K  + M+++    ++   ++KQG  V  + F+VSG++++  +P  H     HHF                       +K      +E+Y K ++ +   + Q N       K  ++CL+       G    IGD+E++L +     T   T    + VL   +++R+L KR+P S+ +M ++ + ++     RL    LPL        LY +   +      K P+  ++    ++ + D I       KG LI+++GPG+VF+ I+ + N R +++K  R+K   +  F  +Q++  ++ GR
Sbjct:    8 IVLVCGVRSTWGAMAHLYDTVISLITQPAEKRSDAEIEQILPWFRKKSDMFKHLHSEVLKDIIKNCEFTSCQRDSVIIRQGEKGDCFFIILTGTVSIHINTSLTDEEFANTRKRQLDEEALVLREGPDLHPLDRSKYGNYLGKIEAGKSFGELALISNDCVRNASIISTEVTDLLIVRKDLYNRSLRFHQAQAFEEKQKFVNSLPLFHSWQSRYKNMMAMSLKKEILKFEDVVVKQGAPVDGLIFIVSGQVKVVMDPSQHKTQYPHHFPKGAIADLEKEKARDLLRKEMNLEKKRGFDRKETYQKRSEVVHETKKQAN-------KHLELCLM-------GAVDIIGDLEMVLGLQTYAETIICTEEARLFVLDQNNYDRLLEKRHPQSLNIMKDIVHNKLTLHFSRLSEQTLPLFRFF----LYTLDEKEKKEKLRKAPIVQQERPPQIELSPDGI------QKGPLINMYGPGSVFYLIRMRENKR-RHRKIERSKYTDKLDFNKVQEN-QKASGR 499

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Match: A0A094ZI31 (Uncharacterized protein OS=Schistosoma haematobium OX=6185 GN=MS3_00666 PE=4 SV=1)

HSP 1 Score: 172.17 bits (435), Expect = 1.241e-42
Identity = 124/414 (29.95%), Postives = 197/414 (47.58%), Query Frame = 2

Query:   89 TETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKEL--------FPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTT------------------------------EECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKTYNSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPS---IGDVELLLNMPYSIFTATA-TSHCVVLVLHARHFERIL----LKRNPASILVMLELSYQRIEHWCG-RLGNVLPLL 1186
            +  L E+L KP+  R   EIR +  W +E +   K +S +IL  LV EC  E K+P + ++I EG+IGDCMYILLSGR+ VH     D+  V N+E  EL         P K     +I     LG  +  LE+G +FGEVALIE C+RTAS++                                +   +V I R LYNNTV   +E EF  +++F++++ +F   S + +KQ+ M++E    EY   ++KQG   + +YF+  GE+R++                     + K +Q   + R+     ++ +P      L+   N +   K     IGD+E LL  P  +FT  + TS+ ++  ++ ++ ER      +K N   +L M+ L+  +   +   RL N +  L
Sbjct:    6 SNNLVEVLIKPNNMRTAIEIRHIALWFKENILALKDVSIEILMKLVAECKAEFKYPHD-IIIREGDIGDCMYILLSGRVSVHY--RGDQSAVKNEEMHELMNVKSNSFIPVKQNVSDIINQE--LGPQVGQLEAGSVFGEVALIEDCLRTASILALPNTIEVNRHESSLNQQQQSSSSSLTKQSEKQSVCLVNISRTLYNNTVRVAMENEFHERMKFVKNIIYFQHLSDKIQKQIAMSLEKQKYEYNQVVLKQGSSFNGLYFVYRGELRVTL--------------------HVKQSQTSTTYRNNYRSIKYDLP------LITGSNPNTPEKTGSLCIGDIEFLLKYPNYLFTIISNTSYTILYYMNIKNAERYFYGLHIKFNYYELL-MIHLTMNKFSQFIQLRLQNFIDFL 387

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 62.3882 bits (150), Expect = 1.095e-9
Identity = 43/210 (20.48%), Postives = 91/210 (43.33%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G + V++ N                                 + L ++     FGE+A++  C RTASV         V+ RE+++N +    E   +    F+ SVS  A   +    +++  +E    +    ++++GE  +  Y +  G+++++   + H
Sbjct:  172 KNRYLRRLEGQQIKDMV-ECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNN---------------------------------KLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDH 347

HSP 2 Score: 51.6026 bits (122), Expect = 2.505e-6
Identity = 55/200 (27.50%), Postives = 89/200 (44.50%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEE-CEMVVIPRELYNNTVAPVLEEEFKMKLE-FIESVS 637
            A + A S +    ++ E    I+   ++ R E + RS   +LR  V     L +D L  +V    VE +     VI EGE G+  YI+  G++ V +                    K   EP         Q + TL+ G  FGE ALI   +R+A+++  E+  E +VI RE +  TV     +E K  L+ ++E+++
Sbjct:  251 ASVKAASGVRTWVLDREVFHNIMRMTAEARHE-QHRS---FLRS-VSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQ------------------STKDHEEP---------QVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTF--DELKKYLQGYVETLA 416

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 62.003 bits (149), Expect = 1.494e-9
Identity = 43/210 (20.48%), Postives = 91/210 (43.33%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHH 802
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G + V++ N                                 + L ++     FGE+A++  C RTASV         V+ RE+++N +    E   +    F+ SVS  A   +    +++  +E    +    ++++GE  +  Y +  G+++++   + H
Sbjct:  172 KNRYLRRLEGQQIKDMV-ECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNN---------------------------------KLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDH 347

HSP 2 Score: 52.373 bits (124), Expect = 1.185e-6
Identity = 59/217 (27.19%), Postives = 97/217 (44.70%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEE-CEMVVIPRELYNNTVAPVLEEEFKMKLE-FIESVSFFACCSQRHKKQLLMAI 688
            A + A S +    ++ E    I+   ++ R E + RS   +LR  V     L +D L  +V    VE +     VI EGE G+  YI+  G++ V +                    K   EP         Q + TL+ G  FGE ALI   +R+A+++  E+  E +VI RE +  TV     +E K  L+ ++E+++      +R+ K  L+A+
Sbjct:  251 ASVKAASGVRTWVLDREVFHNIMRMTAEARHE-QHRS---FLRS-VSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQ------------------STKDHEEP---------QVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTF--DELKKYLQGYVETLA--RDDKKRNAKWFLIAV 431

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: ENSAMXT00000002114.2 (cGMP-dependent protein kinase 2-like [Source:NCBI gene;Acc:103041230])

HSP 1 Score: 57.7658 bits (138), Expect = 2.645e-8
Identity = 43/204 (21.08%), Postives = 90/204 (44.12%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            +++D L+ L       +++C  EK + +N++VI EGE G+ +Y+L  G L V                             I++  +LGQ    +  G  FGE+A++  C RTA+V    +  +  + R+ + + +    +   +    F+ SVS      +    +++  +E    +    I+++GE  +  + +  GE+ ++
Sbjct:  173 MNNDFLKKLEPQHTREMVDCMYEKVYTANQLVIQEGEPGNYLYVLAEGLLEV-----------------------------IQNGKLLGQ----MRPGTAFGELAILYNCKRTATVKAVTQSHIWALDRQTFQSIMMRSTQARHEEYFSFLRSVSLLKDLPEEKLAKIVDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVT 343

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 51.9878 bits (123), Expect = 1.861e-6
Identity = 36/175 (20.57%), Postives = 73/175 (41.71%), Query Frame = 2

Query:  266 VIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F   ++    +L   +E    +    I++QG R    + +  G++ ++ E
Sbjct:  119 IIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLAEEILSKLADVLEETHYDDGEYIIRQGARGDTFFIISKGKVNVTRE 260

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Match: prkg1a (protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:ZDB-GENE-040426-1308])

HSP 1 Score: 51.2174 bits (121), Expect = 2.764e-6
Identity = 38/190 (20.00%), Postives = 79/190 (41.58%), Query Frame = 2

Query:  224 VIECTVE-KWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            +++C    ++  +  +I EG++G  +Y++  G++ V +                                  G  L T+  G +FGE+A++  C RTA+V T    ++  I R+ +   +      +    +EF++SV  F    +    +L   +E    E    I++QG R    + +  G++ ++ E
Sbjct:  128 IVDCMYPVEYSKDSCIIKEGDVGSLVYVMEDGKVEVTKE---------------------------------GLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFHGLPEEILSKLGDVLEETHYEDGDYIIRQGARGDTFFIISKGKVTVTRE 284

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Match: si:ch211-272n13.7 (protein kinase cAMP-dependent type II regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9392])

HSP 1 Score: 52.373 bits (124), Expect = 1.614e-7
Identity = 30/120 (25.00%), Postives = 59/120 (49.17%), Query Frame = 2

Query:  425 TSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLS 784
            T+ + +C+    +   FGE+AL+    R A+++ T E  +  + R  +   +     ++ KM   FIE+V          + +++  I S S +   +I+ QGE+    Y + SGE+R++
Sbjct:  202 TNDVSRCVGAYNNRGSFGELALMYNTSRAATIIATSEGALWGLDRLTFRRIIVKNAAKKRKMYECFIETVPLLKSLDFSERLKVVDVIASKSFQDSERIIAQGEKADCFYLVESGEVRIA 321

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001198.1 (pep scaffold:Pmarinus_7.0:GL480445:10050:25657:1 gene:ENSPMAG00000001068.1 transcript:ENSPMAT00000001198.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.0618 bits (118), Expect = 8.626e-7
Identity = 31/132 (23.48%), Postives = 65/132 (49.24%), Query Frame = 2

Query:  395 KIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCE 790
            K+  E L+ D S  G+ L TL+ G +FGE+A++  C RTA+V    +  ++ + R  + + +    +   K+ ++F+++             ++   +E  +      I+ +GE     Y ++ G++R+S E
Sbjct:   50 KVDVEGLL-DVSKQGESLCTLQPGALFGELAILYDCTRTATVKALTDVRLLYLSRHAFRSVLMRESQLRRKLIIKFLKTAKTLKNLPDEQLSKMFDCMEESAFADGEAIVNEGEVGHIFYVILRGQVRVSQE 180

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Match: EDO49032 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHT2])

HSP 1 Score: 80.8777 bits (198), Expect = 7.857e-18
Identity = 48/163 (29.45%), Postives = 88/163 (53.99%), Query Frame = 2

Query:   98 LAE-ILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALI-EKCMRTASVVTTEECEMVVIPRELYNNTV 580
            LAE ILSKPS+ R + ++  +  W R++   FK L DD L  ++   T+ ++  + +++ +GE G+C YI+L G + V+   + D E  T+ E        +R+    E   + G  L++L +G  FGE+ ++ E+  R  +V+  E   ++ I  +LY  ++
Sbjct:   12 LAESILSKPSEQRDDADLEHIICWFRQRSPLFKLLEDDALLDIIKNVTLTRYRKDNIIMRQGEKGNCFYIILKGSVSVYAKQDGDGEAATHHE------QSVRSHK--ERLLLFGAELSSLRAGRSFGEMVMVDERKERNTTVIADEATMLISIDEKLYERSL 166

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Match: EDO38407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCZ7])

HSP 1 Score: 52.373 bits (124), Expect = 4.422e-7
Identity = 47/211 (22.27%), Postives = 83/211 (39.34%), Query Frame = 2

Query:  197 LSDDILQTL-------VIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHA 805
            L +D L+ L       V+EC  E+ +  ++ +I E E G  +Y+L  G+  V                KE                  G  L  +  G  FGE+A++  C RTASV      ++  I R+ +   +           +EF+ SV+     ++ +  ++   IE    E    I++QG R    + + SG + ++     H+
Sbjct:   84 LDNDFLKNLEASQVREVVECMCERMFKRDEYIIKEKEPGSHLYVLEEGKCQV---------------TKE------------------GTVLGHMGPGKAFGELAILYNCTRTASVRAQTSGKLWAIDRQTFQTIMMKTGLMRTAEHMEFLRSVNLLKDLAESYLLKIADVIEETFYEEGEYIIRQGARGDTFFIIKSGNVDITQRTNVHS 261

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Match: EDO32932 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STN2])

HSP 1 Score: 46.2098 bits (108), Expect = 5.228e-6
Identity = 30/114 (26.32%), Postives = 53/114 (46.49%), Query Frame = 2

Query:  248 WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPV 589
            +  ++V+I +G IG   Y ++SG + V R+    +ED T  E                      Q ++ +  G  FGE+AL+    RTA+++  E  E + + ++ +N  V PV
Sbjct:   51 YEQDRVIIKQGHIGVSFYFIVSGSVVVQRV----EEDRTTGEKH-------------------NQIISEMTGGDSFGELALMHDIRRTATIICKERSEFLRVDKDDFNE-VYPV 140

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:101158535])

HSP 1 Score: 57.7658 bits (138), Expect = 2.673e-8
Identity = 52/241 (21.58%), Postives = 100/241 (41.49%), Query Frame = 2

Query:  176 KVKYFKKLSDDILQTLVIECTVEK-WPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKTYNSWNQESYGKMTQKLLSQRDQRN 895
            K +Y ++L    ++ +V EC  E+ +   + VI +GE G+ +++L  G+L V + N                                 + L  +     FGE+A++  C RTASV    + +   + RE + N +    E   +    F+ SVS  A        +++  +E    +    I+++GE  S  Y +  G+++++   +  AH   +  N+  +  Y    +K L   D R+
Sbjct:  173 KNQYLRRLELQQIKDMV-ECMYERNYQQGECVIKQGEPGNHLFVLAEGKLEVFQHN---------------------------------KLLTWITVWTTFGELAILYNCTRTASVRAVNKVKTWALDREAFQNIMRRTAETRHEQYRNFLRSVSLLANLPDDKLSKIVDCLEVEYYDKGEYIIREGEEGSTFYIIAQGKVKVTQTTE--AHKLPQIINALQKGDY--FGEKALVSDDVRS 375

HSP 2 Score: 53.1434 bits (126), Expect = 7.117e-7
Identity = 46/181 (25.41%), Postives = 79/181 (43.65%), Query Frame = 2

Query:   44 AFLCAISTISMTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEE-CEMVVIPRELYNNTVA 583
            A + A++ +    ++ E    I+ + ++ R E + R+   +LR  V     L DD L  +V    VE +   + +I EGE G   YI+  G++ V +  E  K                           L Q +  L+ G  FGE AL+   +R+A+++  +   E +VI RE ++ TV 
Sbjct:  252 ASVRAVNKVKTWALDREAFQNIMRRTAETRHE-QYRN---FLRS-VSLLANLPDDKLSKIVDCLEVEYYDKGEYIIREGEEGSTFYIIAQGKVKVTQTTEAHK---------------------------LPQIINALQKGDYFGEKALVSDDVRSANIIADDNGVECLVIDRETFDQTVG 400

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Match: prkar2aa (cAMP-dependent protein kinase type II-alpha regulatory subunit [Source:NCBI gene;Acc:101159349])

HSP 1 Score: 51.9878 bits (123), Expect = 1.326e-6
Identity = 30/132 (22.73%), Postives = 61/132 (46.21%), Query Frame = 2

Query:  416 IEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHH 811
            I D  + G+C+    +   FGE+AL+    R A+++ T+E  +  + R  +   +     ++ +M   FIESV          + +++  +         +I+ QGE+    Y + SGE+++  + +  A H
Sbjct:  178 IYDIVVSGKCVGQYNNKGSFGELALMYNTPRAATIIATQEGALWGLDRATFRRLIVKNNAKKRRMYETFIESVPLLKTLEPNERMKIVDVLGMKQFLDGERIIAQGEKAECFYIVESGEVKIMMKSKTKADH 309

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000003135.1 (SMESG000003135.1)

HSP 1 Score: 1178.7 bits (3048), Expect = 0.000e+0
Identity = 568/572 (99.30%), Postives = 568/572 (99.30%), Query Frame = 2

Query:   74 MTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKTYNSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLGNVLPLLGLIKDRTLYCMKNLKGYKGPLTLEQLLKRNQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNKKYNRNKLFHQESFKPLQKSFYRSVGRLHRPNDEMKMRTSLFTKEIGYGTHYDNHTKELEGRIGNFLTILDESKSATVEPLSDVLEKIPKIKYPKRGNLVILRPVNKQLRYLRDFNLSSEESVRMYFESKSGK 1789
            MTTINTETLAEILSKPSKDRLEFEIRSVCGW REKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKT NSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLGNVLPLL LIKDRTLYCMKNLKGYKGPLTLEQLLKRNQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNKKYNRNKLFHQESFKPLQKSFYRSVGRLHRPNDEMKMRTSLFTKEIGYGTHYDNHTKELEGRIGNFLTILDESKSATVEPLSDVLEKIPKIKYPKRGNLVILRPVNKQLRYLRDFNLS EESVRMYFESKSGK
Sbjct:    1 MTTINTETLAEILSKPSKDRLEFEIRSVCGWFREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKTCNSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVMLELSYQRIEHWCGRLGNVLPLLELIKDRTLYCMKNLKGYKGPLTLEQLLKRNQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNKKYNRNKLFHQESFKPLQKSFYRSVGRLHRPNDEMKMRTSLFTKEIGYGTHYDNHTKELEGRIGNFLTILDESKSATVEPLSDVLEKIPKIKYPKRGNLVILRPVNKQLRYLRDFNLSPEESVRMYFESKSGK 572

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 162.54 bits (410), Expect = 2.335e-42
Identity = 117/451 (25.94%), Postives = 222/451 (49.22%), Query Frame = 2

Query:   92 ETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIE---DTSILGQCLATLESGHIFGEVALIE-KCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHF---QKTYNSWNQESYGKMTQKLLSQRDQRNKK----------------QFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNM---PYSIFTATATSHCVVLVLHARHFERILL-KRNPASILVMLELSYQRIEHWCGRLGNVLPLLGLIK-DRTLYCMKNLKGYKGPLTLEQL--LKRNQDNIYQYFPPNKGALIDIFGPGTVFF 1354
            E +   ++KPSKDR   EI S+  WLR+K   F  L +++L  ++  C+  +   + ++I +G+ GDC Y++L+GR+ +  +N     D   D    +   K + E + +   D S  G  +A L+SG  FGE+ALI   C+R AS++  E   ++V+ RELYN ++  +  +EF  +L F+++ + F     ++K+Q+  ++      +   ++ QGE  + + F+++G  ++      H   +     T N  N+E        L    D   KK                Q    ++ ++C++            IGD+E  L +     S+ T  AT    V +L A++FER+   K+NP ++ ++ + +  +I+H   RL    P+   I+ +  +   ++ +  +  L  +++  LK N+   + +F  ++G LID++GPG+VF+
Sbjct:    3 EMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIF-INTEAVPDNPEDANVVVTEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATIN--NEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVK-------GGEIIGDIEQGLELTTYASSVITIEATE---VYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRL-EFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNFF-QHRGPLIDLYGPGSVFY 438

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 162.54 bits (410), Expect = 2.361e-42
Identity = 117/451 (25.94%), Postives = 222/451 (49.22%), Query Frame = 2

Query:   92 ETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIE---DTSILGQCLATLESGHIFGEVALIE-KCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHF---QKTYNSWNQESYGKMTQKLLSQRDQRNKK----------------QFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNM---PYSIFTATATSHCVVLVLHARHFERILL-KRNPASILVMLELSYQRIEHWCGRLGNVLPLLGLIK-DRTLYCMKNLKGYKGPLTLEQL--LKRNQDNIYQYFPPNKGALIDIFGPGTVFF 1354
            E +   ++KPSKDR   EI S+  WLR+K   F  L +++L  ++  C+  +   + ++I +G+ GDC Y++L+GR+ +  +N     D   D    +   K + E + +   D S  G  +A L+SG  FGE+ALI   C+R AS++  E   ++V+ RELYN ++  +  +EF  +L F+++ + F     ++K+Q+  ++      +   ++ QGE  + + F+++G  ++      H   +     T N  N+E        L    D   KK                Q    ++ ++C++            IGD+E  L +     S+ T  AT    V +L A++FER+   K+NP ++ ++ + +  +I+H   RL    P+   I+ +  +   ++ +  +  L  +++  LK N+   + +F  ++G LID++GPG+VF+
Sbjct:    6 EMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIF-INTEAVPDNPEDANVVVTEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATIN--NEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVK-------GGEIIGDIEQGLELTTYASSVITIEATE---VYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRL-EFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNFF-QHRGPLIDLYGPGSVFY 441

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 162.54 bits (410), Expect = 4.258e-42
Identity = 117/451 (25.94%), Postives = 222/451 (49.22%), Query Frame = 2

Query:   92 ETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIE---DTSILGQCLATLESGHIFGEVALIE-KCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHF---QKTYNSWNQESYGKMTQKLLSQRDQRNKK----------------QFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNM---PYSIFTATATSHCVVLVLHARHFERILL-KRNPASILVMLELSYQRIEHWCGRLGNVLPLLGLIK-DRTLYCMKNLKGYKGPLTLEQL--LKRNQDNIYQYFPPNKGALIDIFGPGTVFF 1354
            E +   ++KPSKDR   EI S+  WLR+K   F  L +++L  ++  C+  +   + ++I +G+ GDC Y++L+GR+ +  +N     D   D    +   K + E + +   D S  G  +A L+SG  FGE+ALI   C+R AS++  E   ++V+ RELYN ++  +  +EF  +L F+++ + F     ++K+Q+  ++      +   ++ QGE  + + F+++G  ++      H   +     T N  N+E        L    D   KK                Q    ++ ++C++            IGD+E  L +     S+ T  AT    V +L A++FER+   K+NP ++ ++ + +  +I+H   RL    P+   I+ +  +   ++ +  +  L  +++  LK N+   + +F  ++G LID++GPG+VF+
Sbjct:    3 EMVVSCITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIF-INTEAVPDNPEDANVVVTEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATIN--NEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVK-------GGEIIGDIEQGLELTTYASSVITIEATE---VYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRL-EFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNFF-QHRGPLIDLYGPGSVFY 438

[Close]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Match: SMESG000078515.1 (SMESG000078515.1)

HSP 1 Score: 161.384 bits (407), Expect = 4.650e-42
Identity = 116/445 (26.07%), Postives = 220/445 (49.44%), Query Frame = 2

Query:  110 LSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTLVIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDEPKELFPPKIRAEPLIE---DTSILGQCLATLESGHIFGEVALIE-KCMRTASVVTTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQLLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHF---QKTYNSWNQESYGKMTQKLLSQRDQRNKK----------------QFSMPKSFDICLLNQKNQDNGNKPSIGDVELLLNM---PYSIFTATATSHCVVLVLHARHFERILL-KRNPASILVMLELSYQRIEHWCGRLGNVLPLLGLIK-DRTLYCMKNLKGYKGPLTLEQL--LKRNQDNIYQYFPPNKGALIDIFGPGTVFF 1354
            ++KPSKDR   EI S+  WLR+K   F  L +++L  ++  C+  +   + ++I +G+ GDC Y++L+GR+ +  +N     D   D    +   K + E + +   D S  G  +A L+SG  FGE+ALI   C+R AS++  E   ++V+ RELYN ++  +  +EF  +L F+++ + F     ++K+Q+  ++      +   ++ QGE  + + F+++G  ++      H   +     T N  N+E        L    D   KK                Q    ++ ++C++            IGD+E  L +     S+ T  AT    V +L A++FER+   K+NP ++ ++ + +  +I+H   RL    P+   I+ +  +   ++ +  +  L  +++  LK N+   + +F  ++G LID++GPG+VF+
Sbjct:    6 ITKPSKDRTPDEIISISPWLRKKAALFDSLKEEVLNEIIKSCSFSERRRDDIIIRQGDKGDCFYVMLAGRVSIF-INTEAVPDNPEDANVVVTEDKFKDEGMAKKELDRSRYGNFIAILDSGKAFGELALINTDCVRNASIIADELTHLLVVNRELYNRSIKEIQTQEFNERLSFVQNSALFTNWLSKYKRQVAFSLRKEKFGFNMNLITQGEPTNGLTFILNGHAKVVVNANQHVSQYPWLNATIN--NEELRLSDVNDLDKSVDFETKKPLHNSLSKRLPYIEAEQRQAQRNIEVCIVK-------GGEIIGDIEQGLELTTYASSVITIEATE---VYILDAKNFERLCNPKKNPKTLNLLKKKAIYKIKHRGNRL-EFRPIPFYIRLNEMIADEEDRETRESDLKNQKIEALKNNEKGDFNFF-QHRGPLIDLYGPGSVFY 435

The following BLAST results are available for this feature:

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Yeast
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PRKG2	4.640e-8	28.35	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG2	4.640e-8	28.35	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG2	4.847e-8	28.35	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG1	3.109e-6	20.00	protein kinase cGMP-dependent 1 [Source:HGNC Symbo...	[more]
PRKG1	4.819e-6	19.90	protein kinase cGMP-dependent 1 [Source:HGNC Symbo...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
egl-4	1.795e-9	21.95	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	1.795e-9	21.95	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	2.043e-9	21.95	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	2.043e-9	21.95	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	2.076e-9	21.95	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
for	3.524e-10	20.38	gene:FBgn0000721 transcript:FBtr0446099	[more]
for	3.767e-10	20.51	gene:FBgn0000721 transcript:FBtr0473363	[more]
for	3.767e-10	20.51	gene:FBgn0000721 transcript:FBtr0473364	[more]
for	5.023e-10	20.38	gene:FBgn0000721 transcript:FBtr0089310	[more]
for	5.023e-10	20.38	gene:FBgn0000721 transcript:FBtr0089312	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg2	1.120e-9	21.90	protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:Z...	[more]
prkg2	1.510e-9	21.90	protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:Z...	[more]
prkg2	1.585e-9	21.90	protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:Z...	[more]
prkg2	7.808e-9	21.90	protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:Z...	[more]
prkg1a	2.059e-6	20.00	protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
bmp4	5.274e-10	23.79	bone morphogenetic protein 4 [Source:Xenbase;Acc:X...	[more]
camk4	8.595e-7	21.05	calcium/calmodulin-dependent protein kinase IV [So...	[more]
camk4	8.595e-7	21.05	calcium/calmodulin-dependent protein kinase IV [So...	[more]
camk4	1.049e-6	20.87	calcium/calmodulin-dependent protein kinase IV [So...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Prkg2	1.902e-8	29.12	protein kinase, cGMP-dependent, type II [Source:MG...	[more]
Prkg2	1.934e-8	29.12	protein kinase, cGMP-dependent, type II [Source:MG...	[more]
Prkg1	1.767e-6	20.00	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]
Prkg1	2.578e-6	19.90	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q03043\|KGP24_DROME	5.036e-9	20.38	cGMP-dependent protein kinase, isozyme 2 forms cD4...	[more]
sp\|A8X6H1\|EGL4_CAEBR	6.268e-9	21.95	cGMP-dependent protein kinase egl-4 OS=Caenorhabdi...	[more]
sp\|O76360\|EGL4_CAEEL	2.284e-8	21.95	cGMP-dependent protein kinase egl-4 OS=Caenorhabdi...	[more]
sp\|Q64595\|KGP2_RAT	1.139e-7	29.12	cGMP-dependent protein kinase 2 OS=Rattus norvegic...	[more]
sp\|Q61410\|KGP2_MOUSE	1.377e-7	29.12	cGMP-dependent protein kinase 2 OS=Mus musculus OX...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3JNU3	3.238e-64	31.70	uncharacterized protein LOC106174696 OS=Lingula un...	[more]
A0A210QU71	3.145e-59	32.46	cAMP-dependent protein kinase regulatory subunit O...	[more]
K1Q5I1	4.694e-50	30.11	cAMP-dependent protein kinase regulatory subunit O...	[more]
V4BGQ9	6.817e-44	25.10	Uncharacterized protein OS=Lottia gigantea OX=2251...	[more]
A0A094ZI31	1.241e-42	29.95	Uncharacterized protein OS=Schistosoma haematobium...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg2	1.095e-9	20.48	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]
prkg2	1.494e-9	20.48	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]
ENSAMXT00000002114.2	2.645e-8	21.08	cGMP-dependent protein kinase 2-like [Source:NCBI ...	[more]
prkg1b	1.861e-6	20.57	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg1a	2.764e-6	20.00	protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
si:ch211-272n13.7	1.614e-7	25.00	protein kinase cAMP-dependent type II regulatory s...	[more]
ENSPMAT00000001198.1	8.626e-7	23.48	pep scaffold:Pmarinus_7.0:GL480445:10050:25657:1 g...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO49032	7.857e-18	29.45	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38407	4.422e-7	22.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32932	5.228e-6	26.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
prkg2	2.673e-8	21.58	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]
prkar2aa	1.326e-6	22.73	cAMP-dependent protein kinase type II-alpha regula...	[more]

BLAST of cAMP-dependent protein kinase regulatory subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000003135.1	0.000e+0	99.30	SMESG000003135.1	[more]
SMESG000078515.1	2.335e-42	25.94	SMESG000078515.1	[more]
SMESG000078515.1	2.361e-42	25.94	SMESG000078515.1	[more]
SMESG000078515.1	4.258e-42	25.94	SMESG000078515.1	[more]
SMESG000078515.1	4.650e-42	26.07	SMESG000078515.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027644 ID=SMED30027644|Name=cAMP-dependent protein kinase regulatory subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=1858bp
ATTATTGGCATCAGATCAGTAGTCTATTAAAAGTTGATAATTGGCATTTT
TATGTGCAATTTCTACAATATCAATGACAACAATAAATACTGAAACACTT
GCAGAAATTCTGTCAAAACCTTCGAAAGATCGATTGGAATTTGAGATCAG
ATCAGTTTGTGGTTGGCTCAGAGAAAAAGTGAAATATTTCAAAAAGCTTT
CAGATGATATCCTCCAAACTCTTGTCATAGAATGCACAGTAGAAAAGTGG
CCATCCAACAAAGTTGTCATTTGGGAAGGTGAAATAGGAGATTGCATGTA
CATTCTTCTGTCCGGGAGGTTGCATGTACATAGATTAAATGAGCCTGACA
AAGAAGATGTTACAAATGATGAACCAAAAGAGCTATTTCCACCTAAAATT
AGAGCTGAACCATTGATAGAAGATACTTCAATTCTTGGGCAATGCTTAGC
AACTTTAGAGTCCGGTCATATTTTTGGAGAAGTAGCTCTTATAGAAAAAT
GCATGCGAACAGCTAGTGTCGTAACAACGGAAGAATGTGAAATGGTCGTA
ATTCCAAGAGAACTCTATAACAATACTGTTGCTCCAGTTCTTGAGGAAGA
ATTTAAGATGAAGCTGGAATTCATTGAATCAGTATCATTTTTTGCCTGCT
GTTCACAACGCCATAAAAAGCAATTACTAATGGCAATAGAATCACACTCA
TGTGAATATCCTACTCAGATTATGAAACAAGGAGAAAGAGTTTCAGCAAT
GTATTTTCTTGTTAGCGGTGAAATTCGACTCTCTTGTGAACCGCAGCATC
ATGCTCATCATTTCCAGAAAACGTATAATTCGTGGAATCAGGAATCGTAT
GGCAAAATGACTCAGAAATTGCTTTCTCAGAGAGATCAAAGAAACAAAAA
ACAATTCAGCATGCCTAAGTCTTTTGATATTTGTCTATTGAATCAGAAAA
ACCAAGATAATGGAAATAAACCTTCCATTGGTGATGTTGAATTGCTTTTA
AACATGCCATACTCAATCTTTACGGCAACAGCTACAAGCCATTGCGTCGT
ACTCGTTCTTCACGCGAGACATTTCGAAAGAATTCTACTGAAACGAAATC
CTGCCAGTATTCTGGTTATGTTAGAACTATCCTATCAACGAATCGAACAT
TGGTGTGGAAGATTGGGAAATGTATTACCATTATTGGGATTAATTAAAGA
TAGGACACTTTATTGTATGAAAAATCTCAAAGGTTATAAAGGTCCTTTAA
CTTTGGAACAGCTATTAAAGAGGAATCAAGATAATATATATCAATATTTT
CCTCCTAATAAAGGTGCATTAATTGATATTTTTGGGCCAGGAACGGTTTT
CTTTTATATTAAAAATCAGTACAATTTAAGAGAACAAAACAAAAAATATA
ATCGCAACAAATTATTTCACCAGGAATCTTTTAAACCTCTTCAAAAATCA
TTTTACCGAAGCGTTGGACGTCTACATCGGCCGAATGATGAAATGAAAAT
GAGGACATCCCTATTTACAAAAGAGATTGGCTATGGAACGCATTATGACA
ATCACACAAAAGAGTTAGAAGGTCGAATTGGAAACTTTTTAACAATACTG
GACGAATCCAAATCAGCCACTGTTGAGCCGTTATCAGATGTGTTGGAAAA
AATACCAAAAATTAAATATCCCAAAAGAGGGAATCTCGTCATTTTGAGAC
CTGTTAACAAGCAACTAAGATATCTCAGAGATTTCAATTTATCTTCAGAG
GAATCCGTACGAATGTATTTTGAAAGTAAATCAGGAAAATAATTTAAACT
AAATACTTTTTCAATATTTTTTATCTATTTAGAAACAATAAAAATATTTT
TCCGAAAA

protein sequence of SMED30027644-orf-1

>SMED30027644-orf-1 ID=SMED30027644-orf-1|Name=SMED30027644-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=573bp
MTTINTETLAEILSKPSKDRLEFEIRSVCGWLREKVKYFKKLSDDILQTL
VIECTVEKWPSNKVVIWEGEIGDCMYILLSGRLHVHRLNEPDKEDVTNDE
PKELFPPKIRAEPLIEDTSILGQCLATLESGHIFGEVALIEKCMRTASVV
TTEECEMVVIPRELYNNTVAPVLEEEFKMKLEFIESVSFFACCSQRHKKQ
LLMAIESHSCEYPTQIMKQGERVSAMYFLVSGEIRLSCEPQHHAHHFQKT
YNSWNQESYGKMTQKLLSQRDQRNKKQFSMPKSFDICLLNQKNQDNGNKP
SIGDVELLLNMPYSIFTATATSHCVVLVLHARHFERILLKRNPASILVML
ELSYQRIEHWCGRLGNVLPLLGLIKDRTLYCMKNLKGYKGPLTLEQLLKR
NQDNIYQYFPPNKGALIDIFGPGTVFFYIKNQYNLREQNKKYNRNKLFHQ
ESFKPLQKSFYRSVGRLHRPNDEMKMRTSLFTKEIGYGTHYDNHTKELEG
RIGNFLTILDESKSATVEPLSDVLEKIPKIKYPKRGNLVILRPVNKQLRY
LRDFNLSSEESVRMYFESKSGK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000418	head
PLANA:0000420	parapharyngeal region

Vocabulary: **INTERPRO**
Term	Definition
IPR000595	cNMP-bd_dom
IPR014710	RmlC-like_jellyroll
IPR018488	cNMP-bd_CS
IPR018490	cNMP-bd-like

Vocabulary: **molecular function**
Term	Definition
GO:0016301	kinase activity

Vocabulary: **biological process**
Term	Definition
GO:0016310	phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000595	Cyclic nucleotide-binding domain	SMART	SM00100	cnmp_10	coord: 38..187 e-value: 1.6E-6 score: 37.7
IPR000595	Cyclic nucleotide-binding domain	PROSITE	PS50042	CNMP_BINDING_3	coord: 38..186 score: 19.856
IPR000595	Cyclic nucleotide-binding domain	PROSITE	PS50042	CNMP_BINDING_3	coord: 189..236 score: 7.828
IPR000595	Cyclic nucleotide-binding domain	CDD	cd00038	CAP_ED	coord: 189..338 e-value: 2.89909E-8 score: 50.017
IPR000595	Cyclic nucleotide-binding domain	CDD	cd00038	CAP_ED	coord: 39..179 e-value: 4.17053E-21 score: 86.6109
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 8..171 e-value: 4.7E-30 score: 106.1
None	No IPR available	PANTHER	PTHR11635	CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN	coord: 10..345
None	No IPR available	PANTHER	PTHR11635:SF152	CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT	coord: 10..345
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00888	CNMP_BINDING_1	coord: 65..81
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00889	CNMP_BINDING_2	coord: 134..151
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 175..340
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 7..170

Main menu

cAMP-dependent protein kinase regulatory subunit

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Owlery

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