TNF receptor-associated factor

Overview
NameTNF receptor-associated factor
Smed IDSMED30027623
Length (bp)1992
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TNF receptor-associated factor (SMED30027623) t-SNE clustered cells

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30027623) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor-associated factor (SMED30027623) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30027623) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027623

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30027623h1SMcG0019266 Contig52GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30027623h1SMcG0019266 dd_Smed_v4_3706_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30027623h1SMcG0019266 dd_Smed_v4_3706_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30027623h1SMcG0019266 dd_Smed_v4_3706_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 98.5969 bits (244), Expect = 6.435e-21
Identity = 93/350 (26.57%), Postives = 154/350 (44.00%), Query Frame = 1 
Query:  430 IIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  200 VVVSCPH-KCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 542
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 98.5969 bits (244), Expect = 6.435e-21
Identity = 93/350 (26.57%), Postives = 154/350 (44.00%), Query Frame = 1 
Query:  430 IIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  200 VVVSCPH-KCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 542
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 90.5077 bits (223), Expect = 1.584e-18
Identity = 108/431 (25.06%), Postives = 179/431 (41.53%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKC--PRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCN----KFEVLRNEISDHL------HTDSYSHNKLLIDFI----NNLRNE-------IESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            C  C+ ++    Q +CG R+C  C+ + L   S  C      CQ  ++  K  +  D     +I  + + C      C  Q  L  +  H++        C + E  C     K +VLR ++ DH+         + SH K  +  I    + L+NE       I+S+ N++  F+ E       I+   +    N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:   53 CEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQESIV--KDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKN------DCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQVSLLQNESVEKNKSIQSLHNQICSFEIE-------IERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 459
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 85.5001 bits (210), Expect = 9.226e-17
Identity = 91/347 (26.22%), Postives = 153/347 (44.09%), Query Frame = 1 
Query:  454 NCEFQEQLSTIENHMRT-CNENPISCPYFEFGCNKFEVLRNE-----ISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            +C+ Q  +  ++ H  T C    +SCP+    C+   +LR+E     I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  179 HCKSQVPMIALQKHEDTDCPCVVVSCPH---KCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 517
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 85.5001 bits (210), Expect = 9.226e-17
Identity = 91/347 (26.22%), Postives = 153/347 (44.09%), Query Frame = 1 
Query:  454 NCEFQEQLSTIENHMRT-CNENPISCPYFEFGCNKFEVLRNE-----ISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            +C+ Q  +  ++ H  T C    +SCP+    C+   +LR+E     I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  179 HCKSQVPMIALQKHEDTDCPCVVVSCPH---KCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 517
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-1 (TNF Receptor Associated Factor (TRAF) homolog; TRF-1 [Source:UniProtKB/TrEMBL;Acc:G5EG80])

HSP 1 Score: 61.2326 bits (147), Expect = 1.154e-9
Identity = 43/139 (30.94%), Postives = 72/139 (51.80%), Query Frame = 1 
Query: 1021 ELDWKIDKLSQRP------VNSWKYSRPFYSQEFGYKM--CLSLNFGENA-----VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ---PKGQICSSRTINYDFCPSNAAWV-KPTTERNSEIWCFTFLWVTLANDRLR 1386
            +L WKIDKL QR        ++  +S PF S  FGYKM  C  L FG+ +     +++Y  LL+GE D  L WPF   + I+ +DQ   P+ ++  +  I+     +N  ++ +P  ERN+     +F  + +  + ++
Sbjct:  264 QLIWKIDKLQQRTNEAKSGADTTIFSVPFMSHRFGYKMMACACL-FGDGSSAGKSISLYVLLLKGEFDPTLEWPFHRAIKISLLDQNPRPEDRVNITYVIDPRKLKANEKFLARPRGERNAAFGSQSFCSLAILQNYVK 401
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-2 (TNF Receptor Associated Factor (TRAF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N586])

HSP 1 Score: 53.9138 bits (128), Expect = 2.076e-7
Identity = 33/101 (32.67%), Postives = 54/101 (53.47%), Query Frame = 1 
Query: 1075 YSRPFYSQEFGYKM-CLSLNFGENAV-----NVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWV-KPTTERNSEIWCFTFL 1356
            YS+PFYS  +GYKM  ++  +G+        +V+  L++GE DD L WPF+C VT + +   K ++  ++TI  +  P    ++ +P   RN       FL
Sbjct:  184 YSQPFYSHGYGYKMMAVAAPYGDGLAFREYFSVFVCLMKGEWDDILEWPFRCDVTFSILSDDKKELL-TKTIYVNEMPEIQEFLERPEGLRNGTFGFQNFL 283
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf3 (TNF receptor-associated factor 3 [Source:ZFIN;Acc:ZDB-GENE-040801-257])

HSP 1 Score: 90.1225 bits (222), Expect = 2.382e-18
Identity = 79/353 (22.38%), Postives = 158/353 (44.76%), Query Frame = 1 
Query:  436 VKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE------------FKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRIS------KSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKI----------DNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            V CP  +C F   L S + +H   C +  ++C +  +GC+ ++ L  E+ +H  + +  H +++      L  ++E +K+E++E             + E ++  +R     KN  L + ++ ++ + + S + + L +++E+  +       + +  ++ S++     +S +D S  N       +          D+L +  ++   + D +          G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  PS++++ +PT E N    C  F+  T+
Sbjct:  204 VACPN-HCSFSSILRSELSSHQHDCPKAQVTCSFIRYGCS-YKGLNQEMREHESSFASEHLRMMAVRNTTLEAKVEDVKSELMERYKVLPSLSSRLAEVERQYEEMR----EKNRQLEQ-KLVSMQMLMSSHSEKLLEVEMELRELRPLRAMREEVETLRGSVESMRSMVSSLDSSCVNSASGSHTLASLEQQLTRHDDLMSVHDVRLAEMDLKLQVLETASFNGTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLQWPFKQKVTLMLMDQGPARKHLGDAFKPD--PSSSSFRRPTGEMNIASGCPLFVAQTV 547
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 83.5741 bits (205), Expect = 2.583e-16
Identity = 94/449 (20.94%), Postives = 175/449 (38.98%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCN-----------ENPIS-----------------------------------CPYFEFGCN--KFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVR-IDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEI-TSLDSDEE--FDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDR 1380
            C IC   +  A Q  CG R+C  CI   +    + CP  ++      +  ++ +  D     +I  + VKC    C  + +L  +E H+  C              PIS                                   CP+    C   + E++R++++ H  TD               R ++   +NE+ +   E    H+R + E  ++++LN   + +    + S      +   +  +  + +++++E++ +    +   D   +   I  D   N    TE+   L S EE   +   ++  G   W+++  S    N         +S PFY+   GYK+CL L+          N ++++ H ++GE D QLSWP +  + +A +DQ +GQ         +  P   A+ +PT  RN + + + TFL +     R
Sbjct:   71 CPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKM--TRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKN--QVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQ---HHIEVMETKPDLQAFQRPTVMRNPKGFGYVTFLHLQALRQR 506
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 83.5741 bits (205), Expect = 2.583e-16
Identity = 94/449 (20.94%), Postives = 175/449 (38.98%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCN-----------ENPIS-----------------------------------CPYFEFGCN--KFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVR-IDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEI-TSLDSDEE--FDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDR 1380
            C IC   +  A Q  CG R+C  CI   +    + CP  ++      +  ++ +  D     +I  + VKC    C  + +L  +E H+  C              PIS                                   CP+    C   + E++R++++ H  TD               R ++   +NE+ +   E    H+R + E  ++++LN   + +    + S      +   +  +  + +++++E++ +    +   D   +   I  D   N    TE+   L S EE   +   ++  G   W+++  S    N         +S PFY+   GYK+CL L+          N ++++ H ++GE D QLSWP +  + +A +DQ +GQ         +  P   A+ +PT  RN + + + TFL +     R
Sbjct:   71 CPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKM--TRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKN--QVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQ---HHIEVMETKPDLQAFQRPTVMRNPKGFGYVTFLHLQALRQR 506
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 83.5741 bits (205), Expect = 2.583e-16
Identity = 94/449 (20.94%), Postives = 175/449 (38.98%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCN-----------ENPIS-----------------------------------CPYFEFGCN--KFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVR-IDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEI-TSLDSDEE--FDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDR 1380
            C IC   +  A Q  CG R+C  CI   +    + CP  ++      +  ++ +  D     +I  + VKC    C  + +L  +E H+  C              PIS                                   CP+    C   + E++R++++ H  TD               R ++   +NE+ +   E    H+R + E  ++++LN   + +    + S      +   +  +  + +++++E++ +    +   D   +   I  D   N    TE+   L S EE   +   ++  G   W+++  S    N         +S PFY+   GYK+CL L+          N ++++ H ++GE D QLSWP +  + +A +DQ +GQ         +  P   A+ +PT  RN + + + TFL +     R
Sbjct:   71 CPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKM--TRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKN--QVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQ---HHIEVMETKPDLQAFQRPTVMRNPKGFGYVTFLHLQALRQR 506
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf1 (TNF receptor-associated factor 1 [Source:ZFIN;Acc:ZDB-GENE-071120-4])

HSP 1 Score: 64.3142 bits (155), Expect = 2.929e-10
Identity = 98/465 (21.08%), Postives = 169/465 (36.34%), Query Frame = 1 
Query:  211 EIPND-LMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIII--------DYAVNVKISEIIVKCPR---------------------------INCEFQEQLSTIENHMRT-CNENPISCP----------------------------------------------YFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEM-------IEFKTENRFSHVRIDE-----------SNKNESLNKSEIE--------NLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEIT-SLDSDEEFDFGNEKCLGELDWKIDKLSQR---PVNSWK---YSRPFYSQEFGYKMCLSLNF-GENA-----VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ 1239
            E+P D  +C+ CN ++ KA Q  CG RYC  C+   +         K   C+ +  N + D  +        D A+N +I ++ V C                             I C    Q  T+  H+ + C  N  +CP                                              + + GC  F+   +++ +H       H +LL+D    L+  + S    +       +E          + D            S+K  SL+  ++E         L  K+  + N   +L  E+++   S+V +      S   I  ++ +      R  + D L ++ + + S   D  +D       G   W++  +SQ+     NS K   YS  FY+  +G+K+CL L   G+ A     ++++F +++GE D  LSWPFK  VT   +DQ
Sbjct:   34 EVPKDKYLCSNCNNVLNKARQTVCGHRYCLACVNWLVRNNKDLVCTK---CKGEDSNVESDTSVLTPNQFFNDVAINKEILDLKVHCANQGCPWRSTLKNFEDHQSQCEYALIPCNIGCGIMVQRKTLATHLESGCPNNKTACPSCTSVLTPRELQKHVCPSSGDKKTAKTDKKQKNNQPANSKKKEPCIFSDVGC-PFKGNPDKVKEHESCSHAGHLQLLLDVTRALQRTLNSATERVYQDSPVFLEPGPNGSSLAPQADGDIETDGGDPGVSDKAFSLHDDQVELAAGQQLDALQQKVQVIENIISALNREVEKTQISVVAMNRDHCNSQQIIQHLEATVAELQQRLVRKDILISSLQQSISAQQDVSYD-------GTFYWRVCDVSQKQREAANSQKISQYSPAFYTARYGFKVCLRLYLNGDGAGKGSHISLFFVIMKGEYDPILSWPFKHKVTFFLLDQ 487
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 92.0485 bits (227), Expect = 8.280e-19
Identity = 90/374 (24.06%), Postives = 159/374 (42.51%), Query Frame = 1 
Query:  352 KFC--QVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSH-------VRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSI----SEIDDSTKNCP--------IRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENAVN------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            KFC  QV L+  +K   +D         +++ CP + C  +  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  L+ ++ N L  ++  ++NE  E     +  H       + I+   +    N++ I  L   I+   ++   L  EI R  +   D  + +  +Y S+    S+++   KN           + ++ D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +    + +       ++F ++RGE D  L WPFK  V++  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  173 KFCRNQVPLVEMQKHEDVD------CPSVVISCPHM-CSVKSLLRSELNAHLLECVNAPSTCSFKRYGCT-FKGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEI-RNLRQTGDEADGMKSNYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 535
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: egf (epidermal growth factor [Source:Xenbase;Acc:XB-GENE-951823])

HSP 1 Score: 87.4261 bits (215), Expect = 2.018e-17
Identity = 87/405 (21.48%), Postives = 173/405 (42.72%), Query Frame = 1 
Query:  283 CRYCSDCIESYLDGKSKF--CPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEM-IEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNAT-----EITSLDSDEEFDFGNEKCLGELDWKIDKLS--------QRPVNSWKYSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVT-------LANDRLRFKCKVN 1404
            C  C      Y   K KF  CP +  FC+   +    +  +++     ++ +  +  + N   +EQ+    ++   C   PI C Y+EFGC + ++ RN+++ HL   + +H +++   + +  + +    +   I F   ++F       +  + S   S+        +  T E  +L+  I+++   +V       +  H I E+            K++  C         I SLD +   +  +++C G   W+I+  +        +RPV    +S+ FY+ + GYK+CL L+          N ++++ H ++GE D  L WP +  + ++ +DQ +G     +    D  P   A+ +PT  RN + + + TF+ +        + ND L  +C V 
Sbjct:  164 CSQCQSSFPKYSLQKHKFEECPRRQIFCENCALAMALEDKLNHDQTCPLAYVTCEYCQTNL-IREQMPA--HYSMDCTMAPIPCMYYEFGCTE-KMQRNDLARHLQEFTQAHMRMMAQTLRSFSSSVTPTSHMPDISFCDPSQFEPAPPSVATVHSSHTPSQ--------NDCTQETRNLRETIEQLEGRLV-------RQDHQIRELIA----------KMETQCTYVNELKHTIRSLD-NRLGEMESQQCSGIFIWRINNFNSLLKNQEEERPV--VIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVHTMQGEYDSLLPWPLQGTIRLSILDQSEGVAMQDQEEVMDTKPELLAFQRPTVARNPKGFGYVTFMHLQALKQRQYVKNDTLLVRCSVT 536
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 83.1889 bits (204), Expect = 5.046e-16
Identity = 104/473 (21.99%), Postives = 186/473 (39.32%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSK-----------------------------FCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHM-RTC--NENP-------------------------ISCPYFEFGCNKFEVLRNE-----ISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSH-------VRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSI----SEIDDSTKNCP--------IRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENAVN------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            C  C  ++    Q +CG R+C  C+ + L   S                              FC  +++ C+ +LI    +++I    + +  E+   CPR +C+ +     + +H+ +TC   E P                         ISCP+    C+   +LR+E     I  H  + +  H  L+ ++ N L  ++  ++NE  E     +  H       + I+   +    N++ I  L   I+   ++   L  EI R  +   D  + +  +Y S+    S+++   KN           + ++ D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +    + +       ++F ++RGE D  L WPFK  V++  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:   48 CEKCRLVLCNPRQTECGHRFCETCMNAILSSTSPQCMACEDNITKDKVFKDNCCRREVLALQMFCRNETRGCK-ELITLG-NLLIHLKSDCQFEEL--SCPRADCKEKVIRKDLSDHIEKTCKYRETPCKFCRNQVPLVEMQKHEDVDCPSVVISCPHM---CSVKSLLRSEGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEI-RNLRQTGDEADGMKSNYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 510
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 67.781 bits (164), Expect = 2.778e-11
Identity = 89/448 (19.87%), Postives = 184/448 (41.07%), Query Frame = 1 
Query:  229 MCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCP----------------------RINCEFQE---QLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLL-----------IDFINN---LRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLK-IDSLTNENLS-------LKIEIDR-------ISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNS------WKYSRPFYSQEFGYKMCLSLNF-----GENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYD-FCP--SNAAWVKPTTERNSEIWCFTFLWVT 1365
            +C+ C  L+ +  QAQCG RYCS C+   +   ++   G  +   V   +     +I      K   ++  CP                      ++NC + +       I+ H   C + P++C     GC + ++ R ++   L   S+S N  L            + + N   L +E +S+   +   K  +   H R ++++ +  +    ++       D+L  +N +       L  E++R       +++ +   +E ++     + +++ +     +   +++     +E+++ D             G   WKI +  ++  ++        +S PFY+ ++GYKMCL +       G N  ++++F +++G ND  L WPF   VT+  +DQ      ++R    D F P  S++++ +P +E N    C  F  V+
Sbjct:   36 LCSDCKNLLRRPLQAQCGHRYCSHCLNKIIRWVARNWGGVPECPAVCERSDWTGALISVGHEGKCPYLLAPCPACKTIIRAANRDLHSERECPERKLNCRYCKLSFYFPDIKAHDEICPKFPMTCE----GCGRKKIPREKV--RLFVCSFSRNITLSLPCRYAAVGCTEMVENDKCLEHENKSLAEHLA--KVWDYIQHGRKEQNDLSVRMGSLSVQGSPAPPFDTLDKKNTTFENIVSVLNREVERSSHAAEELARQLRAAQEKVEALTTKVRQLERTLGQKELIVAELETRMQESELSTYD-------------GVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ------NNREHVIDAFRPDVSSSSFQRPISEMNIASGCPLFCQVS 456
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 67.3958 bits (163), Expect = 3.953e-11
Identity = 96/428 (22.43%), Postives = 172/428 (40.19%), Query Frame = 1 
Query:  229 MCNICNKLMTKASQAQCGCRYCSDCIESYLD------GKSKFCP---------------GKSKFCQVKLINFKKDIIIDYAVNVKI-SEIIVKCP--RINCEFQE---QLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINN---LRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDI-KESIDKSYHSISEIDDSTKNCPIRGDKI---DNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNS------WKYSRPFYSQEFGYKMCLSLNF-----GENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYD-FCP--SNAAWVKPTTERNSEIWCFTFLWVT 1365
            +C+ C  L+ +  QAQCG RYCS C+   +       G    CP               G    C   L        I  A N  + SE   +CP  ++NC + +       I+ H   C + P++C     GC + ++ R ++   +            + + N   L +E +S+   + +       +    + +   E L         LK D+L  +N + +        +IV +    +++S H+  E+    +    R ++      L  A   T +   E   +      G   WKI +  ++  ++        +S PFY+ ++GYKMCL +       G N  ++++F +++G ND  L WPF   VT+  +DQ      ++R    D F P  S++++ +P +E N    C  F  V+
Sbjct:   36 LCSDCKNLLRRPLQAQCGHRYCSHCLNKIIRWVARNWGGVPECPAVCERSDWTGALISVGHEGKCPYLLAPCPACKTIIRAANRDLHSE--RECPERKLNCRYCKLSFYFPDIKAHDEICPKFPMTCE----GCGRKKIPREKVRLFVCMPCRYAAVGCTEMVENDKCLEHENKSLAEHLAKGSPAPPANAPPNNSAKVAEML---------LKFDTLDKKNTTFE--------NIVSVLNREVERSSHAAEELARQLRAADTRLERTLGQKELIVAELETRMQESELSTYD-----GVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ------NNREHVIDAFRPDVSSSSFQRPISEMNIASGCPLFCQVS 429
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 97.8265 bits (242), Expect = 8.032e-21
Identity = 106/405 (26.17%), Postives = 170/405 (41.98%), Query Frame = 1 
Query:  295 SDCIESYL-----DGKSKFCPGKSKFC-----QVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            +DC E  L     D   K C  +   C     QV +I  +K    D         ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     +   +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  150 ADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPC------VVVSCPH-KCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 541
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 83.5741 bits (205), Expect = 2.812e-16
Identity = 91/347 (26.22%), Postives = 152/347 (43.80%), Query Frame = 1 
Query:  454 NCEFQEQLSTIENHMRT-CNENPISCPYFEFGCNKFEVLRNE-----ISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            +C+ Q  +  ++ H  T C    +SCP+    C+   +LR+E     I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     +   +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  178 HCKSQVPMIKLQKHEDTDCPCVVVSCPH---KCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 516
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 83.5741 bits (205), Expect = 2.812e-16
Identity = 91/347 (26.22%), Postives = 152/347 (43.80%), Query Frame = 1 
Query:  454 NCEFQEQLSTIENHMRT-CNENPISCPYFEFGCNKFEVLRNE-----ISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            +C+ Q  +  ++ H  T C    +SCP+    C+   +LR+E     I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     +   +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  178 HCKSQVPMIKLQKHEDTDCPCVVVSCPH---KCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 516
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf6 (TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072])

HSP 1 Score: 79.337 bits (194), Expect = 5.316e-15
Identity = 95/474 (20.04%), Postives = 185/474 (39.03%), Query Frame = 1 
Query:  178 LMKEI---DFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISD--------------------HLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTEN---RFS----HVRIDESNKNESLNKSEIENLNLKIDSLTNENLSL------------KIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLS--------QRPVNSWKYSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVT-------LANDRLRFKCKVN 1404
             M+EI   D  +   + +   C IC   + +A Q  CG R+C  CI   +      CP  ++      I  +  +  D     +I  + VKCP   C  + +L  +E+H   C    ++CP  +    K +V  + I D                     +H  S     ++ ++   +    +   +  ++  T      FS    H ++  ++    L ++   ++ L   ++ N NL+L            + E     ++I  ++  + +  H I E+    +   +   ++       E      D+  +   ++C G   WKI            +RPV    +S  FY+   GYK+C+ L+          N ++++ H ++GE D  L WPF+  + +  +DQ +  I  +     D  P   A+ +PT  RN + + + TF+ +        + +D L  +C+V+
Sbjct:   49 FMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLE------DKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPV--VIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVS 508
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf5 (TNF receptor-associated factor 5 [Source:MGI Symbol;Acc:MGI:107548])

HSP 1 Score: 63.929 bits (154), Expect = 4.178e-10
Identity = 88/382 (23.04%), Postives = 154/382 (40.31%), Query Frame = 1 
Query:  352 KFCQVKLINFKKDIII----DYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGC-------NKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIK-------------NEMIEFKTENRFSHVRIDESNKNESL-NKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKID--KLSQRPVNSWK----YSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL-WVTLANDR 1380
            +F + K +  K+DI++    D+  N       V CP   C      + +  H+  C E    CP+  +GC       N  E  R  + DH+       N  L   +N L + +E  K             N M  F+    F + +   S+ ++S   ++++  L L+I +     L L+        S+VD  +S+ +    +   D           K D   N  +     ++E F      C  G+L WK+   ++ +R          +S+PFY+   GY++C       +       +++YF ++RGE D  L WPF+  VT+  +DQ   +     T   D  P+++++ +P  E N    C  F+   TL N +
Sbjct:  162 RFREEKCLYCKRDIVVTNLQDHEEN-SCPAYPVSCPN-RCVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTVKGKRGNLLEHERAALQDHMLL-VLEKNYQLEQRVNALLSSLERKKKMAAADSAIQHATNPMSRFQDIFSFLYRKALTSHTDKSAWLEAQVRQL-LQIVNQQPSRLDLR--------SLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKAD--PNSSSFKRPDGEMNIASGCPRFVSHSTLENSK 529
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q13114|TRAF3_HUMAN (TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2)

HSP 1 Score: 98.5969 bits (244), Expect = 3.090e-20
Identity = 93/350 (26.57%), Postives = 154/350 (44.00%), Query Frame = 1 
Query:  430 IIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  200 VVVSCPH-KCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 542
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q60803|TRAF3_MOUSE (TNF receptor-associated factor 3 OS=Mus musculus OX=10090 GN=Traf3 PE=1 SV=2)

HSP 1 Score: 97.8265 bits (242), Expect = 5.618e-20
Identity = 106/405 (26.17%), Postives = 170/405 (41.98%), Query Frame = 1 
Query:  295 SDCIESYL-----DGKSKFCPGKSKFC-----QVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            +DC E  L     D   K C  +   C     QV +I  +K    D         ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     +   +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:  150 ADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPC------VVVSCPH-KCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 541
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q6DJN2|TRF6B_XENLA (TNF receptor-associated factor 6-B OS=Xenopus laevis OX=8355 GN=traf6-b PE=2 SV=1)

HSP 1 Score: 93.5893 bits (231), Expect = 1.098e-18
Identity = 87/360 (24.17%), Postives = 157/360 (43.61%), Query Frame = 1 
Query:  427 EIIVKCPRINCEF------QEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNAT-----EITSLDSDEEFDFGNEKCLGELDWKIDKLS--------QRPVNSWKYSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVT-------LANDRLRFKCKVN 1404
            E+I     + CE+      +EQ+ +  ++   C   PI C Y+EFGC + ++ RN+++ HL   + +H +++   + +      S  ++ I F   N+F  V +  +  + S   S            + E  +L+  I+++   +V       +  H I E+            K++  C         I SL+ D+  D     C G   WKI   S        ++PV    +S  FY+ + GYK+CL L+          N ++++ H ++GE D  L WP    + ++ +DQ +G I   +    D  P   A+ +PTT+RN + + + TF+ +        + ND L  +C VN
Sbjct:  207 ELICPLAYVTCEYCQTNLIREQMPS--HYSMDCTMAPIPCMYYEFGCTE-KMQRNDLARHLQDFTQAHMRMMFQTLRSFSTTPTSHISD-ISFCDPNQFEPVPLSVAPAHPSHMPSH--------QDCSQETRNLRETIEQLEGRLV-------RQDHQIRELIA----------KMETQCTYVNELKHTIRSLE-DKLLDVDGHHCNGVFIWKIKGFSGLQKTQEEEKPV--VIHSPGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVHTMQGEYDSLLPWPLHGTIRLSILDQSEGAIIQDQEEVMDTKPDLLAFQRPTTQRNPKGFGYVTFMHLNTLKQRQYVKNDTLFVRCAVN 534
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q28DL4|TRAF6_XENTR (TNF receptor-associated factor 6 OS=Xenopus tropicalis OX=8364 GN=traf6 PE=2 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 1.674e-16
Identity = 86/405 (21.23%), Postives = 173/405 (42.72%), Query Frame = 1 
Query:  283 CRYCSDCIESYLDGKSKF--CPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEM-IEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNAT-----EITSLDSDEEFDFGNEKCLGELDWKIDKLS--------QRPVNSWKYSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVT-------LANDRLRFKCKVN 1404
            C  C      Y   K KF  CP +  FC+   +    +  +++     ++ +  +  + N   +EQ+    ++   C   PI C Y+EFGC + ++ RN+++ HL   + +H +++   + +  + +    +   I F   ++F       +  + +   S+        +  T E  +L+  I+++   +V       +  H I E+            K++  C         I SLD +   +  +++C G   W+I+  +        +RPV    +S+ FY+ + GYK+CL L+          N ++++ H ++GE D  L WP +  + ++ +DQ +G     +    D  P   A+ +PT  RN + + + TF+ +        + ND L  +C V 
Sbjct:  164 CSQCQSSFPKYSLQKHKFEECPRRQIFCENCAVAMALEDKLNHDQTCPLAYVTCEYCQTNL-IREQMPA--HYSMDCTMAPIPCMYYEFGCTE-KMQRNDLARHLQEFTQAHMRMMAQTLRSFSSSVTPTSHMPDISFCDPSQFEPAPPSVATVHSTHTPSQ--------NDCTQETRNLRETIEQLEGRLV-------RQDHQIRELIA----------KMETQCTYVNELKHTIRSLD-NRLGEMESQQCSGIFIWRINNFNSLLKNQEEERPV--VIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVHTMQGEYDSLLPWPLQGTIRLSILDQSEGVAMQDQEEVMDTKPELLAFQRPTVARNPKGFGYVTFMHLQALKQRQYVKNDTLLVRCSVT 536
[Close]
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q9Y4K3|TRAF6_HUMAN (TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 1.481e-15
Identity = 99/466 (21.24%), Postives = 181/466 (38.84%), Query Frame = 1 
Query:  178 LMKEI---DFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEV--------LRNEIS-DHLHTDSYSHNKLLIDFINNLRNEI-ESIKNEMIEFKTENR-------------FSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKI--------EIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLS--------QRPVNSWKYSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVT-------LANDRLRFKCKVN 1404
             M+EI   D  +   + +   C IC   + +A Q  CG R+C  CI   +      CP  ++      I  +  +  D     +I  ++VKCP   C  + +L  +E+H   C    + CP  +    KF +         R ++S D+        +K + D    L N I E     +I  +  N              FS     E  +   L +   EN    +  L     SL +        E+    ++I  ++  + +  H I E+    +   +   ++       E      D+  +   ++C G   WKI            ++PV    +S  FY+ + GYK+C+ L+          N ++++ H ++GE D  L WPF+  + +  +DQ +  +  +     D  P   A+ +PT  RN + + + TF+ +        + +D L  +C+V+
Sbjct:   49 FMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLE------DKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPV--VIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVS 500
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 154.836 bits (390), Expect = 4.148e-37
Identity = 112/421 (26.60%), Postives = 196/421 (46.56%), Query Frame = 1 
Query:  145 MINEIFEDVWQLMKEIDFVYKSE-IPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEI----ESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIEN-------LNLKIDSLTNENLSL----KIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGEL--------DWKIDKLS-QRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSN-AAWVKPTTERN 1329
            MI    ++V +L+ + +     E + NDL+C +CNKLM  A ++ CGC YC  CI  YL     +CPG    C+   +N + D+  +  ++ +IS I+VKCP I C +  +L  ++ H+  C    + CP    GC +  +L++E++ HL      H +L++ F N L++EI    E+ K ++   K   R      DE          E+ N       L+  I  + NE ++L    + E+ ++   I   ++ I+   + +  +  +     ++  K +       I S + + E    N   L +L         W+I++ S +R   +  YS  F  Q   YK CL+L    + + ++  +++GE DD L WP +  VT++ I+Q   +   +    YD    N  A+ +P  ERN
Sbjct:    1 MIPSKLDNVQELLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYLNLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLDKCTPESVECPCVTIGCEEEPLLKDEMAKHLTDQVLRHTQLIMSFCNELKSEINHNNETTKEDISHLKEVLRVQKALNDEKTAQMEFLIEELRNKDNMILVLSQDIQEVKNEMITLLTSKESELKKLKSDIQIFRQEIEFMKNDLEVVGSTDIKNQVKDLKKEIFGIKMNIDSNNEERERKMNNLIRLNKLCPNVDMDFMWRIEEYSKKRRTVTDVYSDSF--QSHNYKFCLNLYIYGDNLGLWCVIMKGEKDDFLEWPMRRTVTLSIIEQDSLKTHKTTVFQYDTYQRNKKAFDRPKDERN 419
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: I1ZID8 (TNF receptor associated factor-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 134.42 bits (337), Expect = 2.977e-32
Identity = 65/201 (32.34%), Postives = 116/201 (57.71%), Query Frame = 1 
Query:  163 EDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIE 765
            E + +L+   +F  +  +P++L C++C  L+  A Q++CGCR+CS CI  Y+   + +CPG +  C+ + +    +I  DY VN KI+++ VKCP   C+   +L  IE H+R C     +CP+F  GCN+ +++  ++++HL   ++ H+KL+ID I+N+RN+   +  + +E + +           N+   L  SEIE
Sbjct:    4 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLINSEIE 204
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A2K6N2X0 (TNF receptor-associated factor OS=Rhinopithecus bieti OX=61621 GN=TRAF3 PE=3 SV=1)

HSP 1 Score: 116.316 bits (290), Expect = 8.968e-24
Identity = 109/416 (26.20%), Postives = 178/416 (42.79%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEI----------DRISKSIVDIK------ESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            C  C  ++    Q +CG R+C  C+ + L   S  C      CQ  ++  KK    D         ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  N+S+I +L   IDS   +   L  EI          D +  S+  ++      ES+DKS     ++  +T     +  + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:   53 CEKCRLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQESIVKDKKHEDTDCPC------VVVSCPH-KCSVQALLRSELSAHLSECVNAPSTCSFKRYGC-VFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS---AGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 451
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A2U4CQ84 (TNF receptor-associated factor OS=Tursiops truncatus OX=9739 GN=TRAF3 PE=3 SV=1)

HSP 1 Score: 107.071 bits (266), Expect = 9.839e-21
Identity = 104/416 (25.00%), Postives = 176/416 (42.31%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQL-STIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESLNKSEIENLNLK-----IDSLTNENLSLKIEIDRISKS---IVDIKESIDKSYHSISEID--DSTKNCPIRGDKI--------DNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            C  C  ++    Q +CG R+C  C+ + L   S  C      C+  +   KK        + +   ++V CP   C  Q  L S +  H+  C   P +C +  +GC  F+    +I  H  + +  H  LL ++ N+L  ++  ++NE +E         N+     I+   + E L  +E + L+L+     IDS   +   L  EI    +S      +K S++     ++E++  D +     R   +        D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +       G+   ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:   57 CEKCRLVLCNPKQTECGHRFCETCMGALLSSSSPKCTA----CREGISKDKKH------EDTECPCVVVSCPH-KCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQMWKRVIDSQAEKLKELDKEIRPFRQSWEEAGSMKSSVESLQSRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 458
[Close]
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: V8NPB7 (TNF receptor-associated factor 3 (Fragment) OS=Ophiophagus hannah OX=8665 GN=Traf3 PE=4 SV=1)

HSP 1 Score: 105.916 bits (263), Expect = 3.412e-20
Identity = 107/453 (23.62%), Postives = 183/453 (40.40%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSK-----------------------------FCPGKSKFCQVKL------INFKKDIIID-YAVNVKISEIIVKCPRINCEFQEQLSTI-----ENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIE-----FKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVD---IKESIDKSYHSISEIDDSTKNCPIRG----------DKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENAVN------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            C  C+ ++    Q +CG RYC  C+ S L   S                              FC  ++K C+ +L      +NF + +     A  +K  +    C  + C  Q  +S +       H+  C   P +C +  +GC  F+    ++  H  T +  H  LL ++ N L N++  ++NE +E         N+     I+   + E L  N+++I +L   IDS   +   L  EI    ++  +   +K S++   + ++E++   KN                + D + +  +I   D D  F         G L WKI    +R   +        YS+PFY+  FGYKMC  +    + +       ++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ KPT E N    C  F+  T+
Sbjct:   52 CEKCHLILCNPRQTECGHRYCETCMSSLLSSTSPKCTACQETIVKDKIFKDNCCRRELLALQIFCRNENKGCRDQLTLGQLLVNFGRKLYSSPMAKMLKHEDADCPCVMVTCPHQCSVSALLRKELNAHLSECINAPSTCSFKRYGCT-FQGTNQQVKAHEATSAVQHVDLLKEWSNCLENKVAMLQNESLEKNKSIQTLHNQICSFEIEIERQKEMLRSNETKIHHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESIDKNTGQGARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGPSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTV 501
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 83.5741 bits (205), Expect = 2.117e-16
Identity = 102/469 (21.75%), Postives = 188/469 (40.09%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFC---QVKLINFKKDIIIDYAV---NVKISE----------------IIVKCPR-------------INCEFQEQLST--------------IENHMRT-CNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLR-NEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEIT----SLDSDEE--FDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDR-------LRFKCKVN 1404
            C IC   +  A Q  CG R+C+ CI   +    + CP  ++     Q+   NF K  I+   V   NV   E                  V CP+             IN E   +L T              + +H  T C + P++C +  FGC + ++LRN+++ H+   +  H + + D + N   N + S  +      T++R +  R + + +                            E+ ++ +++++++  + +  H + E+             I N   +T++T     L S EE   +   ++  G   W+++  S    N         +S PFY+   GYK+CL L+          N ++++ H ++GE D QLSWP +  + +A +DQ +GQ         +  P   A+ +PT +RN + + + TF+ +   + R       L  +C+V 
Sbjct:   70 CPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNEVLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQLASHCDTDCLKAPVACTFSIFGCRE-KMLRNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQ-------------------------ELQQMRETVLELESRLVRQDHKLRELS------------IRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNAPRCSNYISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQ---HHVEVMETKPDLQAFQRPTVQRNPKGFGYVTFMQLQALHQRGFVRDDVLMVRCEVT 497
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 80.8777 bits (198), Expect = 1.468e-15
Identity = 105/472 (22.25%), Postives = 192/472 (40.68%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFC---QVKLINFKKDIIIDYAV---NVKISE----------------IIVKCPRINCEFQEQLSTIENHM-RTCNENPISCP-------YFE---------FG------CNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVR-IDESNKNESLNKSEIENLNLKIDSLTNENLSLKIE--------IDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEIT----SLDSDEE--FDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDR-------LRFKCKVN 1404
            C IC   +  A Q  CG R+C+ CI   +    + CP  ++     Q+   NF K  I+   V   NV   E                  V CP+  C+     S +E H+ + C+   I+CP       Y E         F       CN  E++RN+++ H  TD           I   R ++  ++N++     E    H+R + +  +N+++N     +         +   S + E        + ++ +++++++  + +  H + E+             I N   +T++T     L S EE   +   ++  G   W+++  S    N         +S PFY+   GYK+CL L+          N ++++ H ++GE D QLSWP +  + +A +DQ +GQ         +  P   A+ +PT +RN + + + TF+ +   + R       L  +C+V 
Sbjct:   70 CPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNEVLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQ--CQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQFHEQLCLFANTVCEYCN-MELIRNQLASHCDTDCLKAPVACTFSIFGCREKM--LRNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELS------------IRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNAPRCSNYISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQ---HHVEVMETKPDLQAFQRPTVQRNPKGFGYVTFMQLQALHQRGFVRDDVLMVRCEVT 521
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 80.8777 bits (198), Expect = 1.468e-15
Identity = 105/472 (22.25%), Postives = 192/472 (40.68%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFC---QVKLINFKKDIIIDYAV---NVKISE----------------IIVKCPRINCEFQEQLSTIENHM-RTCNENPISCP-------YFE---------FG------CNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVR-IDESNKNESLNKSEIENLNLKIDSLTNENLSLKIE--------IDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEIT----SLDSDEE--FDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDR-------LRFKCKVN 1404
            C IC   +  A Q  CG R+C+ CI   +    + CP  ++     Q+   NF K  I+   V   NV   E                  V CP+  C+     S +E H+ + C+   I+CP       Y E         F       CN  E++RN+++ H  TD           I   R ++  ++N++     E    H+R + +  +N+++N     +         +   S + E        + ++ +++++++  + +  H + E+             I N   +T++T     L S EE   +   ++  G   W+++  S    N         +S PFY+   GYK+CL L+          N ++++ H ++GE D QLSWP +  + +A +DQ +GQ         +  P   A+ +PT +RN + + + TF+ +   + R       L  +C+V 
Sbjct:   70 CPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNEVLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQ--CQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQFHEQLCLFANTVCEYCN-MELIRNQLASHCDTDCLKAPVACTFSIFGCREKM--LRNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELS------------IRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNAPRCSNYISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQ---HHVEVMETKPDLQAFQRPTVQRNPKGFGYVTFMQLQALHQRGFVRDDVLMVRCEVT 521
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf5 (TNF receptor-associated factor 5 [Source:NCBI gene;Acc:103031120])

HSP 1 Score: 73.9442 bits (180), Expect = 2.035e-13
Identity = 84/399 (21.05%), Postives = 171/399 (42.86%), Query Frame = 1 
Query:  229 MCNICNKLMTKASQA-QCGCRYCSDCI--ESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMI----EFKTENRF-SHVR--IDESNKNESLNKSEIENLNLKIDSLTNENLSLK--IEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLD---SDEEFD-FGNEKCLGELDWKI-DKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL 1356
            +CN+ + L +   +A QC    C+D +  ++  D +   C  +++ C+     +    + D+       E  V+CP   C    +   +++H   C E    C Y ++GC      R ++  H  T+   H  LL++  + L  +++ ++ +      E K  N   S+++  + + +   S  +  +E     + S+  E   L+  +E D   + +V ++ S+D     ++      ++    G    +     +I       S++ F    +    G+L WK+ D   ++   +   S PFY+   GYK+   +  G         +++Y  L+RG+ D  L WPF+  VT+A +DQ   +   S +   D   +N  + +PT+E N+ +    F+
Sbjct:  124 LCNLQDHLKSCQYEALQCPNSSCTDILLRKNLPDHQRSHCSYRTELCRYCQKPYPVSQLTDHE-KTSCPEAEVQCPN-KCIHLVKRHKLKDHADECPEQETDCIYKKYGCT-VRNKRGQVKVHEQTEFNHHVLLLLESNSKLIKQVDQLQQDFAAQQGELKERNLLVSNLKREVSKCDTTVSAMQRSVEEQRELVSSVKRELKDLRDVLEADLTKEELVSLRASLDSLREQVAMTQSLREHLGALGQTCQSHTRLLDIHVQQLQCSEQRFQQLESTSYDGKLIWKVHDYHRKKEAGTALNSPPFYTSHSGYKLSARVYLGGEGTARGTHLSLYVMLMRGDFDSLLPWPFRQNVTLAVLDQSGNRNHVSLSFTPDLASNN--FRRPTSETNAALGFPRFI 517
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: ENSAMXT00000035169.1 (pep primary_assembly:Astyanax_mexicanus-2.0:9:3354744:3362219:1 gene:ENSAMXG00000029095.1 transcript:ENSAMXT00000035169.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.7734 bits (151), Expect = 3.003e-11
Identity = 40/129 (31.01%), Postives = 63/129 (48.84%), Query Frame = 1 
Query: 1018 GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTL 1368
            G L WKI    +R   +        YS+PFY+  FGYKMC  +    +       ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  P+++++ +PT E N    C  F+  T+
Sbjct:    4 GTLIWKIRDYKRRKAEAVASKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQGPARKHLGDAFKPD--PNSSSFRRPTGEMNIASGCPLFVAQTV 130
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000074.1 (pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-1 gene:ENSPMAG00000000066.1 transcript:ENSPMAT00000000074.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 86.2705 bits (212), Expect = 4.813e-18
Identity = 77/357 (21.57%), Postives = 150/357 (42.02%), Query Frame = 1 
Query:  436 VKCPRI------NCEFQE-QLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIE-IDRISKSIVD---------IKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDS-----DEEFDFGNEKCLGELD----------------WKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENAVN------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL 1356
             +CPR        CE Q      + +H+  C      C + +FGC K++     + +H    +  H  L+     NL  ++  +++++ E          R+ E  K E ++  +  + N  +  +    L+++ E + R+ +S+           ++  +D +  ++ E+          G  + +    T + +LDS     D +  F ++  L E+D                WKI   ++R  ++        YS+PFY+  FGY+MC       + V       ++F ++RGE D  L WPF+  VT+  +DQ   +   S T   D  P+++++ +PT++ N    C  F+
Sbjct:   96 TRCPRYPIPCPNKCEEQSIAREELVSHLGICPYKQAECFFSQFGC-KYKGTLQGLKEHESGATQQHLSLVTARSANLELKVSMLQSQLAERANSADLLGTRVRELEK-ELISVGQTASKNESVLCVVQRMLAVQTERLLRLQESMQGTTRRADHDALRGDLDGTAATLHELGTRVAAIEESGGSVTHSSTPTRLAALDSALSRHDTQL-FAHDTRLAEMDLRFQVLETASYNGKLVWKIRDYARRKQDAVSGRTLSLYSQPFYTSPFGYRMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLPWPFRQRVTLTLLDQGAARRQLSDTFKPD--PASSSFRRPTSDMNIASGCPLFV 447
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002130.1 (pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 gene:ENSPMAG00000001936.1 transcript:ENSPMAT00000002130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 72.7886 bits (177), Expect = 6.581e-14
Identity = 76/345 (22.03%), Postives = 139/345 (40.29%), Query Frame = 1 
Query:  424 SEIIVKCPRINCEFQE-QLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIK------NEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLK------------IEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKI---DNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENAVN------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL 1356
            ++  + CP  NCE      + +  HM  C  +   C +   GC   +     + +H  +   SH  L+I   + L  +   ++        M E  T+ R + +  D S+ + +L  S    L   ++ LT  N  L+             +   + + +  ++E +     ++       + C +   ++   D L +  E   L   E   +      G+L WKI   ++R   +        YS+PFY+  FGYKMC       + V       ++F ++RGE D  L WPF+  VT++ +DQ   +   S T   D  P++ ++ +P  + N    C  F+
Sbjct:   57 AQYPLPCPN-NCEEHGIPRAELSQHMSACAMSTKLCGFHMLGCTFKQGTSESVREHEESAVRSHFTLVISRNSELELQCARLQCSIEDHTNMSEMLTQ-RVAQLEQDLSHWS-TLTGSNNTRLGSTLEMLTQHNEQLQSLHVAQRAPQRDADTAALRRDMATLRERLRALEAALGNPGPCEERCHMHEQRLTMHDGLLDTAE-RRLQVLETAGYS-----GKLVWKIRDYARRKQEAASGRTLSLYSQPFYTSPFGYKMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLEWPFRRRVTLSLLDQGAARRHLSDTFTPD--PASGSFRRPDGDMNVASGCPLFV 390
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 66.6254 bits (161), Expect = 9.648e-12
Identity = 76/371 (20.49%), Postives = 144/371 (38.81%), Query Frame = 1 
Query:  430 IIVKCPRINCEF-QEQLSTIENHMRT-CNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEI---ESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQ---------------RP-VNSWKYSRPFYSQEFGYKMCLSLNF--------GENAVNV-----------YFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTIN----YDFCPSNAAWVKPTTERNSEIWCFT-FLWVTLANDR--LRFKCKV 1401
            ++V C     E  +EQL     H+   C +  + C +   GC   +++R+ ++ H+H  +  H +LL + +  LR ++       +        N  S +        ++   S  +       S          E+DR+ +    ++E +    H I E+   T N      +   L  AT +         +  +  C G   W++++ S+                P   +  +S  FY+   GY++CL L          G  + +V           + HLL+G+ D +L WPFK  + I+ +DQ     C   +++     D  P  +A+ +P+  RN + + +  F+ +   + R  LR  C V
Sbjct:  208 VVVNCKHCQQELIREQLGP---HLEVDCQQAQVPCTFSPLGCEA-QMVRSLLAAHMHEHTQVHMRLLANGLKILRIQVGQGAQPSSAAGSSAPPNSLSWLSSTSGGDVQTAGASRSQG------SRDRAACDCAQELDRLREITRTLEERVVLQLHQIRELSAKTDN------QQGLLAEATRLVRSLEARVAESESRLCAGIFTWRVERFSRLLPGGLASGFASDGMHPDAPAVMHSSGFYTGVPGYRLCLRLQVLSGREVPAGAASPSVLLAGRQPHLALFVHLLQGDYDHRLPWPFKGRIRISVVDQ-----CERDSVHVTEMMDADPQLSAFQRPSVHRNPKGFGYMNFMDINTLHHRSYLRDDCLV 557
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO35237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM27])

HSP 1 Score: 80.4925 bits (197), Expect = 7.554e-16
Identity = 113/506 (22.33%), Postives = 183/506 (36.17%), Query Frame = 1 
Query:  229 MCNICNKLMTKASQAQCGCRYCSDCIESYL---------DGKSK--------------------FCPGKSKFCQ----VKLINFKKDIIIDYAVNV-----KISEIIVK----------CPR-----INCEFQEQLSTIENHMRTCNENPISCP----------------------------YFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINN-------LRNEIESIKNEMIEFKTE------------NRF--SHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDI----KESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDS-DEEFDFGNEKCL---GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL------NFGENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTLANDR 1380
            +CN C   +    QAQCG R+C  CI+  L         DG++                     +C G+   CQ    V +I   +++     V+         EI+++          CP      + C+      T+  H++ C   PI CP                            +   GC  ++V +  + +H +     H  LL             L N++E    E   FKTE             RF   + R+    K  +  K +I  + ++ D    ENL  ++ +    K         KE +      +   DDS  N      ++  L ++  I       E+     ++ +   G   WKIDK ++R   +        YS PFY+  FGYK+C  L      +  +N ++++  L+RGE D  L WPF+  +TI  IDQ  G   S     +D  P + ++ +PT   N    C  F   T+   R
Sbjct:   11 ICNACRMPLNHPMQAQCGHRFCKHCIDVILISPFPACPRDGQTIQALSVFHDRCALVEMQALPCYCHGRCDGCQWTGPVAMITVHEEVCAFIKVSCIHASDGCGEIMLRFQLAKHVEKECPFRLITCVYCQNDVPERTLIEHLKKCPAFPIECPNECGVKRIERKKLSAHTRECPNALTDCRFSPLGCT-YKVKKIALREHQNKHVIKHMILLGRTTGEPQPNLLELENQLERFDGENTSFKTELERHKYEFAQMKERFNDQNARLGIVEKTVANQKGDIAEIWMRFD---QENLVGEVRMRDKLKKFKVKTKANKECLLSLMKRLEVQDDSQTNPNKLNRRLSQLESSITIHKTKLFQEDLRIQIQQAISYDGTFLWKIDKFTERYAEAKSGNATSIYSSPFYTHRFGYKLCARLFPNGDGSARDNYLSIFIALMRGEYDSILPWPFQETITITLIDQDNGMNISE---TFDPDPCSISFQRPTRNINVASGCPRFCSQTVLRTR 509
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48773 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI91])

HSP 1 Score: 75.0998 bits (183), Expect = 2.892e-14
Identity = 100/457 (21.88%), Postives = 187/457 (40.92%), Query Frame = 1 
Query:  139 LKMINEIFEDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCP-GKSKFCQVKLI--NFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTC--------NENPI-------------SCPYFEFGCN--KFEVLRNEISDHLH------TDSYSHNKLLIDFINNLRNEIESIKNEMI-----------EFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDN-LCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNF-------GENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFC--PSNAAWVKPTTERNSEIWCFT 1350
            L  IN+ +    +L +  D  +   + +   C IC   +    Q  CG R+C +CI   +      CP   +   + +L   NF K  ++ + V  ++ +         C ++  L  +E H++ C        NE                +CP     C+  K +V  ++I +HL       T+  +    ++      ++  E+  N  +           E  +     H   +   + E+L +S   N+  ++D L +     +  +  + + + D+K S D+    I+E+         R  +++  +CN T I  LD+   F    E  +  L   I            +S PFY+  +GYKMCL +N        GE+ V+++ H+++G+ D  L WPF   +T++ +DQ   QI S R I+      P+  A+ +PT+ RN + + + 
Sbjct:   28 LPFINQ-YGGPQRLEEGYDEFFDPPLESKYECPICLLGLRDPVQTPCGHRFCFNCIRRSIRDAGPKCPVDNTPLSERELYRDNFAKREMMSFIVWCRLKK------ERGCTWKGALKELEEHLKGCPCMDTNCPNECGAVMQRKEVDKHCAEACPNRSVPCDHCKMKVTISKIEEHLKGCPCMDTNCPNECGAVMQRKEVDKHCAEACPNRSVPCDHCKMKSSKEQASHGPQEHTPHEAELRREALFQSA--NMQREVDMLGSRGDEYRQFLAYLERKVEDVKTSSDRR---IAELTHKLMRLETREIELEGRVCNGTFIWKLDN---FRQCREGSIAGLTAAI------------HSPPFYTSMYGYKMCLRMNLNGVDGGLGEH-VSLFIHMMQGDWDGILEWPFIGRITLSILDQ-SDQIDSRRPISETLVAKPNLLAFQRPTSPRNHKGYGYV 455
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO49464 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG36])

HSP 1 Score: 72.0182 bits (175), Expect = 3.612e-13
Identity = 89/486 (18.31%), Postives = 177/486 (36.42%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSK----------------------------FCPGKSKFCQ-VKLINF----------KKDIIIDYAVNVKISEIIVKCPRINCEFQEQ----------LSTIENHMRTCNENPISCP----------------------------YFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIV--DIKESIDKSYHSISEIDD----------------STKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSL-----NFGENA-VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVT 1365
            C +C   +    Q  CG R+C  C+E  L G SK                            +CP +   C+ +K + +          K     +     K+++  ++     CEF+             +++E+H++TC ++P+ CP                            + + GC+ F+  R  +  H    +  H  LL+    N       +  ++ + + E      ++ E  +  ++    +     K++ +       + E+  + + I   +++ +I +    +  I++                 T     R D+ ++     +I   + D +          G   WKID+ ++R            YS PFY   +GYK C  +       G+ + ++++F L+RGE D  L WPF+  VT   +DQ +       T   D  P+++++ +PT+  N    C  F+  T
Sbjct:   21 CPVCGNALKHPVQTPCGHRFCEGCLEPILRGPSKCPVDGEELKIDGVFKDVCCRREILCLACYCPNRQLGCEWMKDLQYLEEHRANCEYKGVQCHNPGCQEKVAKRDLEAHLERCEFKPSDCQYCLQRIPAASMEDHLQTCEKHPVVCPHCGAEGICRDELLHHQTNICEQAELPCSFAKHGCH-FKGTREALETHFRDQASVHVNLLLTATQNEEKARSEMAAKLSQMEKERAKQQEQMYEQREALAVANQNLRTYQGKLNVIERSVAEQRRELAELKERIQLQEVEAAIREQDRRLGMIENEASRGAAPSSGPGSMGGTMALERRQDRNEHQLALHDIQLAEHDLKLQMLEATSYDGTYIWKIDEYTRRYQEGVSGKTPSIYSPPFYVGRYGYKACARVYPNGDGMGKGSHLSLFFVLMRGEFDALLPWPFRQKVTFKLLDQDRVHDIGD-TFRPD--PTSSSFKRPTSNMNIASGCPLFISHT 502
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJK8])

HSP 1 Score: 71.633 bits (174), Expect = 3.664e-13
Identity = 91/414 (21.98%), Postives = 168/414 (40.58%), Query Frame = 1 
Query:  217 PND-LMCNICNKLMTKASQAQCGCRYCSDCIESYLDGK--------------SKFCPGK-------------------------SKFCQVKLINFKKDIIIDYAVNVKISEIIVK------------CPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCN--KFEVLRNE-----ISDHLHT--DSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESL--NKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATE----ITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSL---NFGENA---VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ 1239
            PND L+C IC+ ++ +     CG  YC  CIE + +GK              S+  P K                          K   +K+ + K    I    NVK+  I+++            C   N  + ++      H   C    + C + E GC     E  R+E     +  HLH   ++   NK   + I++L  E++ ++ E+ + K+ +    V       +E++  NK +IE L+ +    +N     K ++D + K +    E+I K+   I+++  + K     G  +  +CN  +      +  +++E   GN     ++    D +          S PFY+  +GYKM L      +G+     +++   +++GE D  L WPF+  +T++ I+Q
Sbjct:   24 PNDELICAICHMVVNEPVLTSCGHSYCKYCIEKWCNGKEVVTCPVDNEQLKPSQIFPDKKTDRIVLSLEVKCTNNPCRWKGELRQKQKHLKICSHKAVKCILEGCNVKVPRILMEKHTNTCGWRLLHCKPCNLSYPKKDEETVQHKDDCPLAFLPCRFSEIGCTFKGRESARDEHCESAVQTHLHIACETIRDNK---EQISDLHKELDKVRQEL-QTKSCDHMKEVNAIREKHDEAIRDNKGQIEALSKEHGIASNTIHENKEQLDTLKKELGIASETIRKNRDQIAKLSTACKTQYTDGTFVWRICNYKDKYKKAVAFATNQEVKGGNSDSDDDISMAGDIM---------VSLPFYTSRYGYKMRLKAYPNGYGDGKGTHLSLSIRIMKGEYDAILEWPFRRKITLSLINQ 424
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO43806 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXN6])

HSP 1 Score: 66.6254 bits (161), Expect = 3.745e-13
Identity = 41/148 (27.70%), Postives = 79/148 (53.38%), Query Frame = 1 
Query:  169 VWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLD---GKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRI--NCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHT 597
            V Q ++++D       PN L+C IC +++ +A    CG  +C  C+E++++   G+++ CP     C+  L  ++ D I   A+   +  +IV CP     C+   +L  +E H+++C+  P+ C     GC+ F + R E+++H +T
Sbjct:    5 VQQFIEKVD-------PN-LLCGICAEVLERAVLTPCGHSFCGVCLETWMNAKLGENEKCPASCPSCRADL--YQGDTIPVLALRGIVDGLIVHCPNADNGCKLVLKLEGVEGHLKSCSHAPVQC----CGCSAF-LKRGELAEHHNT 137
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf3 (TNF receptor associated factor 3 [Source:NCBI gene;Acc:101161601])

HSP 1 Score: 94.7449 bits (234), Expect = 2.908e-20
Identity = 96/404 (23.76%), Postives = 161/404 (39.85%), Query Frame = 1 
Query:  232 CNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRI--NCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHL--------HTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNL------KIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCL-GELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL 1356
            C  C  ++ +  Q +CG R+C  CI   L   +  CP   +        FK  I  D   + +I  + V C      C+ Q  L  I +H+  C    + CP    G  K  ++R EI +HL         T  +  NK+ +        E++  K  +      +  +H       ++E L  S  E L         +  L +E  SL+  +D +   +  +++    S  +             + ++ D++ +  EI   D D  F         G L WKI    +R  ++        YS+PFY+  FGYKMC  +    +       ++++F ++RGE D  L WPFK  VT+  +DQ   +         D  PS++++ +P  E N    C  F+
Sbjct:   48 CEACRLVLCQPRQTECGHRFCYSCINDILSCPNPVCPADME------PLFKDKIFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIPDHVNVCPFFEVPCP---LGKCKERMMRKEIPEHLAWKCKYRESTCEFCKNKMPL-------TELQKHKETVCPAFPVSCPNHCTSSSLPRSEKLMSSHTEKLLELELELRSLRQLRDEMESLRGTLDTVRTRLSALEQGGRASLET-------------QLNRHDDMLSVHEIRLADMDLRFQVLETASYNGTLIWKIRDYKRRKQDAVAGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQGPSRKHLGDAFKPD--PSSSSFRRPVAEMNIASGCPLFV 420
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 71.633 bits (174), Expect = 1.160e-12
Identity = 60/270 (22.22%), Postives = 123/270 (45.56%), Query Frame = 1 
Query:  490 NHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNL-RNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDI-------KESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ 1239
            +H ++C ++  +CP+ E GC K  V   +IS+H H+ +  H +LL+  + ++ R  +++  +   E++ ++     R  +     + +   + +L+ K+ +L N    L  E++R S ++          +E I+   + I +++ S     ++  + + +    +  + D             G   WKI   S R   +        +S  FYS ++GYKMCL L    +       ++++F ++R + D  L WPF   VT+  +DQ
Sbjct:  207 DHAKSCAKSKSACPFSEVGC-KSVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDTSPSG--EWQEDSGLGLYRAPDDGCGAAASVPSV-DLDKKVSALENIVCVLNREVERSSLTLEAFSHQHRLDQEKIENLSNKIRQLERSLTVKDLQLSEAEQMVRELQYCTYD-------------GIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ 459
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 71.633 bits (174), Expect = 1.224e-12
Identity = 60/270 (22.22%), Postives = 123/270 (45.56%), Query Frame = 1 
Query:  490 NHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNL-RNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDI-------KESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ 1239
            +H ++C ++  +CP+ E GC K  V   +IS+H H+ +  H +LL+  + ++ R  +++  +   E++ ++     R  +     + +   + +L+ K+ +L N    L  E++R S ++          +E I+   + I +++ S     ++  + + +    +  + D             G   WKI   S R   +        +S  FYS ++GYKMCL L    +       ++++F ++R + D  L WPF   VT+  +DQ
Sbjct:  200 DHAKSCAKSKSACPFSEVGC-KSVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDTSPSG--EWQEDSGLGLYRAPDDGCGAAASVPSV-DLDKKVSALENIVCVLNREVERSSLTLEAFSHQHRLDQEKIENLSNKIRQLERSLTVKDLQLSEAEQMVRELQYCTYD-------------GIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ 452
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:101161132])

HSP 1 Score: 71.633 bits (174), Expect = 1.229e-12
Identity = 68/328 (20.73%), Postives = 138/328 (42.07%), Query Frame = 1 
Query:  457 CEFQEQLSTIENHMRT-CNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLS------QRPVNSWKYSRPFYSQEFGYKMCLSLNFG-------ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ-PKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCF-TFLWVTLANDRLRFK 1392
            CE       +E+H  T C + PI+C +  FGC K  + R+ ++ H+   +  H + + +F+  L               T  +  H++    +  +    +   N ++   +L+  N S   +     + I ++   + K  H + E+        ++  +   L       S+  +   +   ++  G   W++   S      +  +   ++S  FY+   GYK+CL L+          N ++++ H ++G  D QL+WPF+  + +A +DQ P+GQ         +  P   A+ KP  +RN + + + TF+  +L + R   K
Sbjct:  226 CEMDLIRDQMESHCDTDCPKAPIACTFSIFGC-KERMQRHNLAQHMQEFTQMHMRYMAEFLRGLALN-----------GTAPKPLHLQGGPVSCRDQGAAAPASNCSVAPGALSCSNSSASCQPSEEMQRIREMDARLVKQDHQLRELII------LKDTQAGQLAELRRRVSVLEETVKELEAQQYHGIFIWRLKAFSTHLRSQEAGIPVVEHSPGFYTGRPGYKLCLRLHLQTPTAPRCSNFISLFVHTMQGVFDSQLTWPFQGTIRLAILDQGPEGQ---HHMEVMETKPDLQAFQKPINQRNPKGFGYVTFMHRSLLSQRAYVK 532
[Close]
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: ENSORLT00000020861.2 (TNF receptor-associated factor 2 [Source:NCBI gene;Acc:101167626])

HSP 1 Score: 62.3882 bits (150), Expect = 8.892e-10
Identity = 60/306 (19.61%), Postives = 128/306 (41.83%), Query Frame = 1 
Query:  490 NHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTEN--------RFSHVRIDESNKNES-----------------LNKSEIENLNLKIDS-------LTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATE------------ITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWK------YSRPFYSQEFGYKMCLSLNFGENA------VNVYFHLLRGENDDQLSWPFKCVVTIAAIDQ 1239
            +H++ C++    C +   GC+   V + +I DH    SY H  LL+ FI  ++  +ES++ + +E  ++         R   +R+ +  ++ +                 L+ +    L L++ S       L+     L++++      +  +   +++S  ++   +   +   +  DKI+ L N               I  ++   + D       G   WKI   +++  ++        +S  FY+ ++GYKMCL +    +       ++++F ++RG +D  L WPF   VT+  +DQ
Sbjct:  205 DHIKFCSKFKAPCRFHVVGCDT-SVEKEKIHDHERQCSYEHLNLLLHFIMGIKVSLESLQPQRLEVASQKLHELHQSLRDLELRMSQLGRSGTAPLQGVCAATLATSFTPLHSAMGAALELQLQSEKTKVAELSRRCQELELKVSTFENIVCILNRELERSCATMEAYNRQHR---LDQDKIEILSNKVRQLERTVSLRDLSIVEMEGKMK-DMSAATYDGIFIWKISDFTKKRQDAMAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 505
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000026595.1 (SMESG000026595.1)

HSP 1 Score: 843.573 bits (2178), Expect = 0.000e+0
Identity = 414/421 (98.34%), Postives = 417/421 (99.05%), Query Frame = 1 
Query:  145 MINEIFEDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTLANDRLRFKCKVNC 1407
            MINEIFEDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENP SCPYFEFGCNKFEVLRNEISDHL+TDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVR+ ESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGD+IDNLCNATEI SLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQP GQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTLANDRLRFKCKVNC
Sbjct:    1 MINEIFEDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPTSCPYFEFGCNKFEVLRNEISDHLYTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRMVESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDQIDNLCNATEIISLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPNGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFLWVTLANDRLRFKCKVNC 421
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070143.1 (SMESG000070143.1)

HSP 1 Score: 323.939 bits (829), Expect = 6.781e-104
Identity = 179/446 (40.13%), Postives = 265/446 (59.42%), Query Frame = 1 
Query:  163 EDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFK----TENRFSHVRIDESNKN---ESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYH-SISEIDDST------------------KNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGEN-AVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL------WVTLANDRLRFKCKV 1401
            E ++++MKE  F  ++EI  +  CNICN+LM KA  A CGC +CSDCIE YLDG  KFCPG S++CQ K++N+  DI+ D   NVKISEIIVKCPR NCEF+++L  I NHMRTC++ PISCP+   GC   EV+ +E+  HL+ D+Y H+KLLID INNL +E+ES+KNE+IE +     + +  ++ +  +++    E  ++ EIE LN ++  L ++N  L+ EI   ++SI  +++ I  +   S+ +ID+                    +        ID   N  E+  +D  + F   N +  GE +WKI+ LS++    W YS+ FYS   GY+MCLS+N  +N  + V FHL+RG++D +L WPFK  VT+  ID   G+I ++ TI Y     +  W KP  +RN  I+ + +        V  +N+RL  KC+V
Sbjct:    3 ESIYKIMKENKFEIENEIIREFRCNICNELMIKACSAPCGCSFCSDCIEQYLDGADKFCPGTSRYCQKKMVNYANDIVTDNRANVKISEIIVKCPRQNCEFEDELEMIGNHMRTCDKRPISCPFNAIGCKVNEVMNDEMKTHLNVDNYWHSKLLIDMINNLLSEMESMKNEIIEIRENSQLKQKIDNIELQSASQPKICEMESRREIEQLNEEMAVLKDDNRRLRSEIGTNAQSITTMRQQIGMTETISLLQIDELKQNQQQQQEQLNNEVEMLRRETETLKRIIDGKINDLELGIVDMKKRFI--NAEICGEFEWKINNLSEQWKRKWIYSKSFYSGTEGYRMCLSVNIDDNLGIYVGFHLMRGDSDGKLEWPFKYAVTVDVIDTANGEIWNTETIKYSDWLDDVGWRKPAKDRNQIIYVYEYPNYIPLNAVPTSNNRLLMKCRV 446
[Close]
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070162.1 (SMESG000070162.1)

HSP 1 Score: 324.324 bits (830), Expect = 2.850e-103
Identity = 195/502 (38.84%), Postives = 273/502 (54.38%), Query Frame = 1 
Query:  136 LLKMINEIFEDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRID--------------ESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESID-------------KSYH----------------SISEIDDSTKNCPIRGDK---------IDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVN----------------------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL------WVTLANDRLRFKCKV 1401
            ++ +++++ E ++++MKE +F   +EI  +L C ICN+LM KA  A CGC +CSDCIE YLDG  KFCPG S+ CQ+K+IN+  DI+ID   NVKISEIIVKCPR NCEF+++L  IENH+RTC++ PIS P+   GC   E + +E+  HL+ D+Y H+KLL D INNL  E+ES+KNE IE K EN     +ID              E   NE  N+ EIE LN ++  L NEN  L+ EI+  ++SI  I++ I              K  H                 I+++++   N   R D          ID   N  E+  ++   E  F N +  GE +WKI+ LSQ+  + W +S+PFYS   GYKMCLS+N     +                       V F+++RG++DD+L+WPFK  VTI  ID   G I  S TI Y   P  A W+KP T+RN  I  + +          + N+RL  KC++
Sbjct:    1 MISILDKMSESIYKIMKENNFEIVNEISKELKCYICNELMIKACSAPCGCCFCSDCIEQYLDGDDKFCPGTSRRCQMKMINYANDIVIDIRANVKISEIIVKCPRKNCEFEDELEMIENHVRTCDKRPISYPFNAIGCKVNEAMNDEMKAHLNEDNYWHSKLLTDLINNLLGEMESMKNENIELKRENSQFKQKIDNIELQSANQQQKICEMESNEMENRGEIEQLNEEMVVLKNENRRLRSEIETNAQSINAIRQQIGIIETKSQLQIDELKQNHQQQQQELNDEAEMPRREINKLNEQNANGASRVDNNNGETFKQVIDGEINNLELRMIEM--ETRFINAQIRGEFEWKIENLSQQVKDKWIHSKPFYSGPNGYKMCLSVNINHLEIENLSQRVRGRRMCLNVIIDWRICVGFYMMRGDSDDKLAWPFKYAVTIDVIDTANGDIWRSETIKYSDRPDAAGWMKPVTDRNERIPVYKWPDHIPLNSPPIRNNRLLIKCRL 500
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BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070162.1 (SMESG000070162.1)

HSP 1 Score: 322.013 bits (824), Expect = 1.723e-102
Identity = 195/493 (39.55%), Postives = 266/493 (53.96%), Query Frame = 1 
Query:  163 EDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRID--------------ESNKNESLNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESID-------------KSYH----------------SISEIDDSTKNCPIRGDK---------IDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVN----------------------VYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWCFTFL------WVTLANDRLRFKCKV 1401
            E ++++MKE +F   +EI  +L C ICN+LM KA  A CGC +CSDCIE YLDG  KFCPG S+ CQ+K+IN+  DI+ID   NVKISEIIVKCPR NCEF+++L  IENH+RTC++ PIS P+   GC   E + +E+  HL+ D+Y H+KLL D INNL  E+ES+KNE IE K EN     +ID              E   NE  N+ EIE LN ++  L NEN  L+ EI+  ++SI  I++ I              K  H                 I+++++   N   R D          ID   N  E+  ++   E  F N +  GE +WKI+ LSQ+  + W +S+PFYS   GYKMCLS+N     +                       V F+++RG++DD+L+WPFK  VTI  ID   G I  S TI Y   P  A W+KP T+RN  I  + +          + N+RL  KC++
Sbjct:    3 ESIYKIMKENNFEIVNEISKELKCYICNELMIKACSAPCGCCFCSDCIEQYLDGDDKFCPGTSRRCQMKMINYANDIVIDIRANVKISEIIVKCPRKNCEFEDELEMIENHVRTCDKRPISYPFNAIGCKVNEAMNDEMKAHLNEDNYWHSKLLTDLINNLLGEMESMKNENIELKRENSQFKQKIDNIELQSANQQQKICEMESNEMENRGEIEQLNEEMVVLKNENRRLRSEIETNAQSINAIRQQIGIIETKSQLQIDELKQNHQQQQQELNDEAEMPRREINKLNEQNANGASRVDNNNGETFKQVIDGEINNLELRMIEM--ETRFINAQIRGEFEWKIENLSQQVKDKWIHSKPFYSGPNGYKMCLSVNINHLEIENLSQRVRGRRMCLNVIIDWRICVGFYMMRGDSDDKLAWPFKYAVTIDVIDTANGDIWRSETIKYSDRPDAAGWMKPVTDRNERIPVYKWPDHIPLNSPPIRNNRLLIKCRL 493
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BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000065606.1 (SMESG000065606.1)

HSP 1 Score: 315.464 bits (807), Expect = 6.380e-101
Identity = 176/433 (40.65%), Postives = 256/433 (59.12%), Query Frame = 1 
Query:  163 EDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYCSDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKCPRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLHTDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTE-----NRFSHVRIDESNKNESLNKSEIE------NLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISEIDDSTKNCPIRGDKIDNLCNATEITSLDSD-EEFDFGNEKCLGELDWKIDKLSQRPVNSWKYSRPFYSQEFGYKMCLSLNFG---ENAVNVYFHLLRGENDDQLSWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAA--WVKPTTERNSEIWCFTFLWVTLA---NDRLRFKCKV 1401
            E +W+ M+E +     E+  +L C ICNK+M KA  A CGCR+CSDCI+ +LDG  KFCPG S++CQ ++IN+  DI ID+ +N++ISEI+V CPR NCEF ++L  IENHMRTCN+  ISCP+   GC   E+   E+  HL  D Y H+KLLI+ INNLRNEIES+K+E I+ K E      +  ++ +  +N+ + +   E++       +N +I ++ N N +L+ E+  + + I   K+ ID ++  ISE     +N      K      A EI  + +  E  +F N    G LDW+IDKLSQ     W YS PFYS   GYKMC+++N       A+ V F+L+RG+ D  L WPFK  V + AI+   G + SS+++     P+ AA  W +P ++RN  I  FT  +  L+   ND+L  KC++
Sbjct:    3 ESIWKFMRENEIKISCEVSKELQCKICNKMMIKACHAPCGCRFCSDCIQHHLDGNDKFCPGTSRYCQNRMINYATDIAIDWPINIRISEIVVNCPRQNCEFNDELQMIENHMRTCNKRLISCPFNAIGCEMNEIRNEEMKSHLDEDIYCHSKLLIELINNLRNEIESMKSENIQLKKEISQSRQQNQNIELQLTNQKQKMCVMEVKEQENRGEINEEIAAVNNANRALQNEMIELRRKISQFKQQID-AFKQISEQQQLQQNIKNEMKKC-----ANEIPQIQTKFENAEFIN---FGILDWQIDKLSQLERGKWIYSEPFYSGPDGYKMCVAVNITSIWSGAIRVRFYLMRGDCDAGLEWPFKYAVKVDAINPADGNVYSSQSVKCPDSPAAAAAKWGRPASDRNDRI-SFTDYFTNLSAIKNDKLLLKCRI 425
The following BLAST results are available for this feature:
BLAST of TNF receptor-associated factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRAF36.435e-2126.57TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF36.435e-2126.57TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF31.584e-1825.06TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF39.226e-1726.22TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF39.226e-1726.22TNF receptor associated factor 3 [Source:HGNC Symb... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
trf-11.154e-930.94TNF Receptor Associated Factor (TRAF) homolog; TRF... [more]
trf-22.076e-732.67TNF Receptor Associated Factor (TRAF) homolog [So... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf32.382e-1822.38TNF receptor-associated factor 3 [Source:ZFIN;Acc:... [more]
traf62.583e-1620.94TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf62.583e-1620.94TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf62.583e-1620.94TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf12.929e-1021.08TNF receptor-associated factor 1 [Source:ZFIN;Acc:... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ssh28.280e-1924.06slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
egf2.018e-1721.48epidermal growth factor [Source:Xenbase;Acc:XB-GEN... [more]
ssh25.046e-1621.99slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
TRAF22.778e-1119.87TNF receptor associated factor 2 [Source:NCBI gene... [more]
TRAF23.953e-1122.43TNF receptor associated factor 2 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Traf38.032e-2126.17TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf32.812e-1626.22TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf32.812e-1626.22TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf65.316e-1520.04TNF receptor-associated factor 6 [Source:MGI Symbo... [more]
Traf54.178e-1023.04TNF receptor-associated factor 5 [Source:MGI Symbo... [more]
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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q13114|TRAF3_HUMAN3.090e-2026.57TNF receptor-associated factor 3 OS=Homo sapiens O... [more]
sp|Q60803|TRAF3_MOUSE5.618e-2026.17TNF receptor-associated factor 3 OS=Mus musculus O... [more]
sp|Q6DJN2|TRF6B_XENLA1.098e-1824.17TNF receptor-associated factor 6-B OS=Xenopus laev... [more]
sp|Q28DL4|TRAF6_XENTR1.674e-1621.23TNF receptor-associated factor 6 OS=Xenopus tropic... [more]
sp|Q9Y4K3|TRAF6_HUMAN1.481e-1521.24TNF receptor-associated factor 6 OS=Homo sapiens O... [more]
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BLAST of TNF receptor-associated factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1E1014.148e-3726.60TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
I1ZID82.977e-3232.34TNF receptor associated factor-2 (Fragment) OS=Sch... [more]
A0A2K6N2X08.968e-2426.20TNF receptor-associated factor OS=Rhinopithecus bi... [more]
A0A2U4CQ849.839e-2125.00TNF receptor-associated factor OS=Tursiops truncat... [more]
V8NPB73.412e-2023.62TNF receptor-associated factor 3 (Fragment) OS=Oph... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf62.117e-1621.75TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf61.468e-1522.25TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf61.468e-1522.25TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf52.035e-1321.05TNF receptor-associated factor 5 [Source:NCBI gene... [more]
ENSAMXT00000035169.13.003e-1131.01pep primary_assembly:Astyanax_mexicanus-2.0:9:3354... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000000074.14.813e-1821.57pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-... [more]
ENSPMAT00000002130.16.581e-1422.03pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 g... [more]
traf69.648e-1220.49TNF receptor-associated factor 6 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO352377.554e-1622.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO487732.892e-1421.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO494643.612e-1318.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483943.664e-1321.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO438063.745e-1327.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf32.908e-2023.76TNF receptor associated factor 3 [Source:NCBI gene... [more]
traf2b1.160e-1222.22TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf2b1.224e-1222.22TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf61.229e-1220.73TNF receptor associated factor 6 [Source:NCBI gene... [more]
ENSORLT00000020861.28.892e-1019.61TNF receptor-associated factor 2 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000026595.10.000e+098.34SMESG000026595.1[more]
SMESG000070143.16.781e-10440.13SMESG000070143.1[more]
SMESG000070162.12.850e-10338.84SMESG000070162.1[more]
SMESG000070162.11.723e-10239.55SMESG000070162.1[more]
SMESG000065606.16.380e-10140.65SMESG000065606.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027623 ID=SMED30027623|Name=TNF receptor-associated factor|organism=Schmidtea mediterranea sexual|type=transcript|length=1992bp
TTTTATTGCAAATTTTAAATCTTTCCATTTTCTATTTAAAAATTTTTTTA
TTAAAATTGAGATTCATTGTTATTTATTGAATATGGTTCTATTATTATCT
TATAATGACATTTTAACTCAGAATTAATATAATTTTTATTGAAAATGATT
AATGAAATTTTTGAAGACGTATGGCAATTAATGAAAGAAATCGATTTTGT
TTACAAATCTGAAATTCCAAATGATTTGATGTGCAATATTTGTAATAAAT
TAATGACAAAAGCTTCTCAAGCACAGTGTGGATGTAGGTATTGTTCAGAC
TGTATTGAATCTTATTTGGATGGTAAAAGCAAATTTTGTCCTGGAAAATC
AAAATTTTGTCAAGTTAAACTTATAAATTTCAAAAAGGATATTATTATTG
ACTATGCTGTCAATGTGAAAATATCAGAAATAATTGTAAAATGTCCAAGA
ATAAACTGTGAATTTCAGGAGCAATTGAGTACAATAGAAAACCACATGAG
AACTTGTAATGAAAATCCCATCAGTTGTCCATATTTTGAATTCGGGTGTA
ATAAATTTGAAGTTTTACGCAATGAAATTAGTGATCATCTTCATACGGAT
AGTTATTCCCACAATAAACTGTTGATAGATTTTATCAATAATTTACGCAA
CGAAATAGAATCAATTAAGAATGAAATGATTGAATTCAAAACAGAGAATC
GATTTTCTCATGTGAGAATAGATGAATCGAACAAAAATGAATCTTTAAAT
AAATCGGAAATAGAAAATCTAAATCTGAAAATAGACTCATTGACAAATGA
AAATTTATCTTTGAAAATTGAAATTGATAGAATTTCAAAATCAATAGTTG
ATATTAAAGAATCGATCGATAAATCATATCATTCAATTTCAGAAATCGAT
GACTCAACAAAAAATTGTCCAATCAGAGGCGACAAAATCGATAATCTGTG
CAACGCTACTGAAATAACAAGTTTGGATAGCGATGAGGAATTTGATTTCG
GGAATGAGAAATGTTTAGGAGAACTTGATTGGAAAATCGATAAACTAAGC
CAGCGGCCAGTAAATTCATGGAAATACAGTCGGCCATTTTATTCTCAAGA
ATTCGGGTATAAAATGTGCTTGAGTTTGAATTTTGGGGAAAATGCGGTAA
ATGTTTATTTTCATTTACTGCGTGGAGAGAACGATGACCAACTGAGTTGG
CCATTCAAATGCGTTGTGACGATTGCGGCGATCGATCAACCCAAGGGGCA
AATATGCTCGAGTCGGACGATTAATTACGATTTCTGTCCCAGCAATGCGG
CTTGGGTCAAGCCGACAACCGAGAGGAATTCGGAAATTTGGTGCTTCACG
TTTTTGTGGGTCACTCTGGCAAATGATAGGCTGAGATTTAAGTGTAAAGT
CAATTGTTAGTAGGCTATTTTCTGTTGATTTTGGTAATTTTTCACATTCC
CGTTAATAACACGCATTATTGGCTATCGAAAGCAAATGTTGGAAAATATG
ATTATTGTTAATTGTAACAAAAATATTAAATAATAACAATGCAACTGTTT
ATGATAAATTTATTTTTAGGTTATCTGGTTGTCGTTGTAAAGTGTATTAT
ATAAAGGCTTGTCGTGGCATGCTTTAGAAAAGAGAAATATGGGAATTCGA
TAAACTTAATGTTCTTCGGGGGAAAGTGGTAACCGGTGACAAATGAGATT
TAGAAAACGAATAACATAATTGTAAATTGATAAGAGGTTAATAGAAGGGT
TAGGGGCCTTAAACAAATTATTGTTCATTATGTTAAATCATGAAAACCGA
TTGAGCTGAGTGTACTCTGATTTCTGAGCTTGATAATTATAAATTGATTG
CCAGATTTAGAAAGTTTAAGGGAAACTATATAAAAACGCAGACATACTAA
ACAAAACACCAGTTGATAAGTCTACAAGAAGTTAATATAAAAAATTGAAA
ATTAAACCAAATTCGTATATAAAATGGTGGCGTCGCTGCTTG
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protein sequence of SMED30027623-orf-1

>SMED30027623-orf-1 ID=SMED30027623-orf-1|Name=SMED30027623-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=422bp
MINEIFEDVWQLMKEIDFVYKSEIPNDLMCNICNKLMTKASQAQCGCRYC
SDCIESYLDGKSKFCPGKSKFCQVKLINFKKDIIIDYAVNVKISEIIVKC
PRINCEFQEQLSTIENHMRTCNENPISCPYFEFGCNKFEVLRNEISDHLH
TDSYSHNKLLIDFINNLRNEIESIKNEMIEFKTENRFSHVRIDESNKNES
LNKSEIENLNLKIDSLTNENLSLKIEIDRISKSIVDIKESIDKSYHSISE
IDDSTKNCPIRGDKIDNLCNATEITSLDSDEEFDFGNEKCLGELDWKIDK
LSQRPVNSWKYSRPFYSQEFGYKMCLSLNFGENAVNVYFHLLRGENDDQL
SWPFKCVVTIAAIDQPKGQICSSRTINYDFCPSNAAWVKPTTERNSEIWC
FTFLWVTLANDRLRFKCKVNC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0000209protein polyubiquitination
GO:0001503ossification
GO:0001843neural tube closure
GO:0002726positive regulation of T cell cytokine production
GO:0007249I-kappaB kinase/NF-kappaB signaling
GO:0007250activation of NF-kappaB-inducing kinase activity
GO:0009887animal organ morphogenesis
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030316osteoclast differentiation
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032147activation of protein kinase activity
GO:0032743positive regulation of interleukin-2 production
GO:0042088T-helper 1 type immune response
GO:0042102positive regulation of T cell proliferation
GO:0042475odontogenesis of dentin-containing tooth
GO:0042981regulation of apoptotic process
GO:0043011myeloid dendritic cell differentiation
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507positive regulation of JUN kinase activity
GO:0045084positive regulation of interleukin-12 biosynthetic process
GO:0045410positive regulation of interleukin-6 biosynthetic process
GO:0045453bone resorption
GO:0045672positive regulation of osteoclast differentiation
GO:0045892negative regulation of transcription, DNA-templated
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0046849bone remodeling
GO:0048468cell development
GO:0050852T cell receptor signaling pathway
GO:0051023regulation of immunoglobulin secretion
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092positive regulation of NF-kappaB transcription factor activity
GO:0051865protein autoubiquitination
GO:0070498interleukin-1-mediated signaling pathway
GO:0070534protein K63-linked ubiquitination
GO:0070555response to interleukin-1
GO:0071222cellular response to lipopolysaccharide
GO:0071345cellular response to cytokine stimulus
GO:1901224positive regulation of NIK/NF-kappaB signaling
GO:1904996positive regulation of leukocyte adhesion to vascular endothelial cell
GO:2000679positive regulation of transcription regulatory region DNA binding
GO:0006955immune response
GO:0007165signal transduction
GO:0016567protein ubiquitination
Vocabulary: molecular function
TermDefinition
GO:0005164tumor necrosis factor receptor binding
GO:0019901protein kinase binding
GO:0031435mitogen-activated protein kinase kinase kinase binding
GO:0031624ubiquitin conjugating enzyme binding
GO:0031625ubiquitin protein ligase binding
GO:0031996thioesterase binding
GO:0042802identical protein binding
GO:0042826histone deacetylase binding
GO:0043422protein kinase B binding
GO:0047485protein N-terminus binding
GO:0061630ubiquitin protein ligase activity
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0004842ubiquitin-protein transferase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
GO:0005811lipid particle
GO:0005829cytosol
GO:0005886plasma membrane
GO:0009898cytoplasmic side of plasma membrane
GO:0032991macromolecular complex
GO:0035631CD40 receptor complex
GO:0048471perinuclear region of cytoplasm
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
Vocabulary: INTERPRO
TermDefinition
IPR043211TNF_rcpt-assoc_TRAF
IPR008974TRAF-like
IPR013083Znf_RING/FYVE/PHD
IPR001841Znf_RING
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 157..184
NoneNo IPR availableCOILSCoilCoilcoord: 206..233
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 114..400
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 12..129
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 23..101
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 11..131
e-value: 1.6E-14
score: 55.8
IPR008974TRAF-likeGENE3DG3DSA:2.60.210.10coord: 263..421
e-value: 1.5E-26
score: 95.0
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 295..419
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 96..152
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 114..400
coord: 12..129
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 30..66
score: 8.904