CYLD lysine 63 deubiquitinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30027594 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Human
Match: CYLD (CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584]) HSP 1 Score: 169.859 bits (429), Expect = 3.472e-43 Identity = 118/390 (30.26%), Postives = 197/390 (50.51%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRET----DIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D I + ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 383 SEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 770
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Human
Match: CYLD (CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584]) HSP 1 Score: 169.474 bits (428), Expect = 1.181e-42 Identity = 135/472 (28.60%), Postives = 225/472 (47.67%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Human
Match: CYLD (CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584]) HSP 1 Score: 169.474 bits (428), Expect = 1.181e-42 Identity = 135/472 (28.60%), Postives = 225/472 (47.67%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Human
Match: CYLD (CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584]) HSP 1 Score: 169.474 bits (428), Expect = 1.181e-42 Identity = 135/472 (28.60%), Postives = 225/472 (47.67%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Human
Match: CYLD (CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584]) HSP 1 Score: 169.474 bits (428), Expect = 1.212e-42 Identity = 135/472 (28.60%), Postives = 225/472 (47.67%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 486 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 955
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Celegans
Match: cyld-1 (CYLinDromatosis (Human disease gene) homolog [Source:UniProtKB/TrEMBL;Acc:H2L265]) HSP 1 Score: 124.79 bits (312), Expect = 5.319e-29 Identity = 111/375 (29.60%), Postives = 168/375 (44.80%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEI----RNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFL-HSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLF---YMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFAYY--------CSNHLSNCK----HKKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK-----PEIRETDIGKYFMS--------------------NKEDDLDSEHVTRIKKFAFVCFYKNPT 2421
G ++GIQG NSCY+D + +AMF FD L K SE + I+ IV+PLRK YV + V + RK L L P L + EKDPEE+L +F + +P +K N K S ++ + ++ +TS+ +L++ K P LI+QLPR+G K F ++L IDI+ + CS+C S C C + +Y C +H HK L K ++ L A+LCIE +HYVAYV+T +W+++DSMA D+ L P +RE ++S K+ LD V R+ +++CFY++ +
Sbjct: 452 GRQKGIQGYCNSCYLDATLYAMFVQTTCFDFLLEKSIKGSETAQQFQKILAHEIVFPLRKVHYVRADHVMKLRKLLAELMPHVTGLTNEEKDPEEILGFIFSKVFHAEPFIKLIG-QNHAKDSQYLVPIVVDDWLGGAATSQ-----HLLERHMRSAQVTFAKAPPVLIMQLPRYGQQ-KVFDKILPLETIDITPFVAGAVPACSKCQACSEVYCPTCFLTRRVFYSEVIFCRKCFHHTHLLPEIEDHKSRDLYPPGKPQKKPHSHKMVLSAVLCIETSHYVAYVRTSS--NQWVFFDSMA--DREGLSDGFNVPVVRECGNMSDWLSLQGWNRLKDADECGQIKAMFGKQSSLDPL-VGRLLSDSYICFYEDAS 814
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Celegans
Match: cyld-1 (CYLinDromatosis (Human disease gene) homolog [Source:UniProtKB/TrEMBL;Acc:H2L265]) HSP 1 Score: 124.405 bits (311), Expect = 7.981e-29 Identity = 97/301 (32.23%), Postives = 142/301 (47.18%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEI----RNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFL-HSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLF---YMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFAYY--------CSNHLSNCK----HKKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMA 2274
G ++GIQG NSCY+D + +AMF FD L K SE + I+ IV+PLRK YV + V + RK L L P L + EKDPEE+L +F + +P +K N K S ++ + ++ +TS+ +L++ K P LI+QLPR+G K F ++L IDI+ + CS+C S C C + +Y C +H HK L K ++ L A+LCIE +HYVAYV+T +W+++DSMA
Sbjct: 510 GRQKGIQGYCNSCYLDATLYAMFVQTTCFDFLLEKSIKGSETAQQFQKILAHEIVFPLRKVHYVRADHVMKLRKLLAELMPHVTGLTNEEKDPEEILGFIFSKVFHAEPFIKLIG-QNHAKDSQYLVPIVVDDWLGGAATSQ-----HLLERHMRSAQVTFAKAPPVLIMQLPRYGQQ-KVFDKILPLETIDITPFVAGAVPACSKCQACSEVYCPTCFLTRRVFYSEVIFCRKCFHHTHLLPEIEDHKSRDLYPPGKPQKKPHSHKMVLSAVLCIETSHYVAYVRTSS--NQWVFFDSMA 801
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Celegans
Match: cyld-1 (CYLinDromatosis (Human disease gene) homolog [Source:UniProtKB/TrEMBL;Acc:H2L265]) HSP 1 Score: 124.02 bits (310), Expect = 1.096e-28 Identity = 97/301 (32.23%), Postives = 142/301 (47.18%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEI----RNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFL-HSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLF---YMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFAYY--------CSNHLSNCK----HKKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMA 2274
G ++GIQG NSCY+D + +AMF FD L K SE + I+ IV+PLRK YV + V + RK L L P L + EKDPEE+L +F + +P +K N K S ++ + ++ +TS+ +L++ K P LI+QLPR+G K F ++L IDI+ + CS+C S C C + +Y C +H HK L K ++ L A+LCIE +HYVAYV+T +W+++DSMA
Sbjct: 762 GRQKGIQGYCNSCYLDATLYAMFVQTTCFDFLLEKSIKGSETAQQFQKILAHEIVFPLRKVHYVRADHVMKLRKLLAELMPHVTGLTNEEKDPEEILGFIFSKVFHAEPFIKLIG-QNHAKDSQYLVPIVVDDWLGGAATSQ-----HLLERHMRSAQVTFAKAPPVLIMQLPRYGQQ-KVFDKILPLETIDITPFVAGAVPACSKCQACSEVYCPTCFLTRRVFYSEVIFCRKCFHHTHLLPEIEDHKSRDLYPPGKPQKKPHSHKMVLSAVLCIETSHYVAYVRTSS--NQWVFFDSMA 1053
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Fly
Match: CYLD (gene:FBgn0032210 transcript:FBtr0080072) HSP 1 Score: 148.288 bits (373), Expect = 2.868e-37 Identity = 110/375 (29.33%), Postives = 180/375 (48.00%), Query Frame = 1
Query: 1429 CGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRN------IMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFA---YYCSNHLSNCKHKKFSLKVKR-----------------KENIFEGKVELELFAILCIEKTHYVAYVKTGEVL-GKWIYYDSMA--KTDQSVLK-PEIRETDIGKYFMS----------NKEDDLDSEHVTRIKKFAFVCFYKNPTLEYY 2433
CG +GIQG NSCY+D + F+MF F +FDS+ + +IRN ++R IV PLRK +V +RV + R+ L L EKDPEE L +L + +P LK + +G Q + QLF + + + + ++ +++F + + P C I+Q+PR G +YK + +L +D++ +I +CS C ++ + C C + A C+ C K F +KR E++ ++ +ELFA++CIE +HYVA+VK+G W ++DSMA K +Q+ PEI ++S + D + EH RI A++C Y++ + Y
Sbjct: 183 CGKFKGIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQIMRVEPFLK---LSSG--QDSYFYQLFVEKDEKLT-LPSVQQLFEQSFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRDCFGSLQAGSGLECTAFCPKCL-KTFHSHIKRTNHVSKKIYSPKEFKIMAEHMVVPRLYMELFAVVCIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINETSTNDKVLPEHAKRIFCDAYMCLYQSTDIMMY 550
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Fly
Match: CYLD (gene:FBgn0032210 transcript:FBtr0080070) HSP 1 Score: 147.902 bits (372), Expect = 9.902e-37 Identity = 110/375 (29.33%), Postives = 179/375 (47.73%), Query Frame = 1
Query: 1429 CGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRN------IMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFA---YYCSNHLSNCKHKKFSLKVKR-----------------KENIFEGKVELELFAILCIEKTHYVAYVKTGEVL-GKWIYYDSMA--KTDQSVLK-PEI----------RETDIGKYFMSNKEDDLDSEHVTRIKKFAFVCFYKNPTLEYY 2433
CG +GIQG NSCY+D + F+MF F +FDS+ + +IRN ++R IV PLRK +V +RV + R+ L L EKDPEE L +L + +P LK + +G Q + QLF + + + + ++ +++F + + P C I+Q+PR G +YK + +L +D++ +I +CS C ++ + C C + A C+ C K F +KR E++ ++ +ELFA++CIE +HYVA+VK+G W ++DSMA K +Q+ PEI E ++ D + EH RI A++C Y++ + Y
Sbjct: 271 CGKFKGIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQIMRVEPFLK---LSSG--QDSYFYQLFVEKDEKLT-LPSVQQLFEQSFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRDCFGSLQAGSGLECTAFCPKCL-KTFHSHIKRTNHVSKKIYSPKEFKIMAEHMVVPRLYMELFAVVCIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINETSTNDKVLPEHAKRIFCDAYMCLYQSTDIMMY 638
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Fly
Match: CYLD (gene:FBgn0032210 transcript:FBtr0080071) HSP 1 Score: 147.902 bits (372), Expect = 9.902e-37 Identity = 110/375 (29.33%), Postives = 179/375 (47.73%), Query Frame = 1
Query: 1429 CGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRN------IMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFA---YYCSNHLSNCKHKKFSLKVKR-----------------KENIFEGKVELELFAILCIEKTHYVAYVKTGEVL-GKWIYYDSMA--KTDQSVLK-PEI----------RETDIGKYFMSNKEDDLDSEHVTRIKKFAFVCFYKNPTLEYY 2433
CG +GIQG NSCY+D + F+MF F +FDS+ + +IRN ++R IV PLRK +V +RV + R+ L L EKDPEE L +L + +P LK + +G Q + QLF + + + + ++ +++F + + P C I+Q+PR G +YK + +L +D++ +I +CS C ++ + C C + A C+ C K F +KR E++ ++ +ELFA++CIE +HYVA+VK+G W ++DSMA K +Q+ PEI E ++ D + EH RI A++C Y++ + Y
Sbjct: 271 CGKFKGIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVFVRSDRVMKLRELLDQLSSVSGLTCEEKDPEEFLNSLLSQIMRVEPFLK---LSSG--QDSYFYQLFVEKDEKLT-LPSVQQLFEQSFHSSDIKLKEVPSCFIIQMPRFGKNYKMYPRILPSQVLDVTDIIENSPRQCSLCGKLAEYECRDCFGSLQAGSGLECTAFCPKCL-KTFHSHIKRTNHVSKKIYSPKEFKIMAEHMVVPRLYMELFAVVCIETSHYVAFVKSGSGPDAPWCFFDSMADRKGEQNGYNIPEITCVPELTQWLSEEGARSINETSTNDKVLPEHAKRIFCDAYMCLYQSTDIMMY 638
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Zebrafish
Match: cylda (cylindromatosis (turban tumor syndrome), a [Source:ZFIN;Acc:ZDB-GENE-061108-2]) HSP 1 Score: 166.392 bits (420), Expect = 6.549e-42 Identity = 114/390 (29.23%), Postives = 202/390 (51.79%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRK--ENIFEGKV----ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEI-RETDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ ++ E + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLL+ + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ L V ++ E+++ ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ R ++G+Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 524 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYKETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLRLRSAGQKV-QDCYFYQIF-MDKKDKVMVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLDDTPRECRICGGLALYECRECYEDYDITPGKIKQFCEKCNTQVHLHPRRKIHRYVKLSVPKELHESVWRQGSYPHQQMELFAVLCIETSHYVAFVKYGSADSAWLFFDSMADRDGGQNGFNIPQVSRCPEVGEYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 911
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Zebrafish
Match: cylda (cylindromatosis (turban tumor syndrome), a [Source:ZFIN;Acc:ZDB-GENE-061108-2]) HSP 1 Score: 166.007 bits (419), Expect = 8.931e-42 Identity = 114/390 (29.23%), Postives = 202/390 (51.79%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRK--ENIFEGKV----ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEI-RETDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ ++ E + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLL+ + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ L V ++ E+++ ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ R ++G+Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 563 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYKETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLRLRSAGQKV-QDCYFYQIF-MDKKDKVMVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLDDTPRECRICGGLALYECRECYEDYDITPGKIKQFCEKCNTQVHLHPRRKIHRYVKLSVPKELHESVWRQGSYPHQQMELFAVLCIETSHYVAFVKYGSADSAWLFFDSMADRDGGQNGFNIPQVSRCPEVGEYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 950
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Zebrafish
Match: cylda (cylindromatosis (turban tumor syndrome), a [Source:ZFIN;Acc:ZDB-GENE-061108-2]) HSP 1 Score: 166.007 bits (419), Expect = 8.931e-42 Identity = 114/390 (29.23%), Postives = 202/390 (51.79%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRK--ENIFEGKV----ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEI-RETDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ ++ E + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLL+ + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ L V ++ E+++ ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ R ++G+Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 563 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYKETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLRLRSAGQKV-QDCYFYQIF-MDKKDKVMVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLDDTPRECRICGGLALYECRECYEDYDITPGKIKQFCEKCNTQVHLHPRRKIHRYVKLSVPKELHESVWRQGSYPHQQMELFAVLCIETSHYVAFVKYGSADSAWLFFDSMADRDGGQNGFNIPQVSRCPEVGEYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 950
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Zebrafish
Match: cyldl (cylindromatosis (turban tumor syndrome), like [Source:ZFIN;Acc:ZDB-GENE-131127-190]) HSP 1 Score: 152.91 bits (385), Expect = 7.142e-38 Identity = 102/325 (31.38%), Postives = 163/325 (50.15%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG--DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVK-QSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNK------FAYYCS-------NHLSNCKHKKFSLKVKR----KENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKT---DQSVLKPEIRE-TDIGKYF 2334
G +GIQG NSCYMD++ F++F+ + DSL K + I++I+ IV PLRK +VS V RK+L + EKDPEE L + + DPLL + K QSC+ Q+F M+ + + ++L+ +F + + P CLIL +PR G +K F +++ ++DI+ L+ +C C ++N C C ++ F Y+C+ +H H SL + + +++ +LELFA+LCIE +HYV++VK G WI++DSMA PE+R ++G+Y
Sbjct: 398 GQNKGIQGHCNSCYMDSALFSVFSCSSVLDSLLFKSINPEDKTIQDILLKNIVNPLRKQGFVSARCVMNLRKQLQKREHCPTYTTDEKDPEEFLSLIMQEILFLDPLLSLCQSGSRHKVQSCYYYQIF-MDYNHHLVLPTVQQLLEHSFYSNSLKLAEVPACLILTMPRSGKSFKMFPKIIPSTELDITGLLADSPQQCVSCGLLANEECAECFRDALFSDTGFKYFCTKCSTQVHSHQQRRHHTPSSLHLPQGFSYSDSLTPPPEKLELFAVLCIETSHYVSFVKHGPRDTDWIFFDSMADRVGESNGYNIPEVRACPEVGQYL 721
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Zebrafish
Match: cyldl (cylindromatosis (turban tumor syndrome), like [Source:ZFIN;Acc:ZDB-GENE-131127-190]) HSP 1 Score: 152.91 bits (385), Expect = 7.142e-38 Identity = 102/325 (31.38%), Postives = 163/325 (50.15%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG--DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVK-QSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNK------FAYYCS-------NHLSNCKHKKFSLKVKR----KENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKT---DQSVLKPEIRE-TDIGKYF 2334
G +GIQG NSCYMD++ F++F+ + DSL K + I++I+ IV PLRK +VS V RK+L + EKDPEE L + + DPLL + K QSC+ Q+F M+ + + ++L+ +F + + P CLIL +PR G +K F +++ ++DI+ L+ +C C ++N C C ++ F Y+C+ +H H SL + + +++ +LELFA+LCIE +HYV++VK G WI++DSMA PE+R ++G+Y
Sbjct: 398 GQNKGIQGHCNSCYMDSALFSVFSCSSVLDSLLFKSINPEDKTIQDILLKNIVNPLRKQGFVSARCVMNLRKQLQKREHCPTYTTDEKDPEEFLSLIMQEILFLDPLLSLCQSGSRHKVQSCYYYQIF-MDYNHHLVLPTVQQLLEHSFYSNSLKLAEVPACLILTMPRSGKSFKMFPKIIPSTELDITGLLADSPQQCVSCGLLANEECAECFRDALFSDTGFKYFCTKCSTQVHSHQQRRHHTPSSLHLPQGFSYSDSLTPPPEKLELFAVLCIETSHYVSFVKHGPRDTDWIFFDSMADRVGESNGYNIPEVRACPEVGQYL 721
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Xenopus
Match: tril (TLR4 interactor with leucine-rich repeats [Source:Xenbase;Acc:XB-GENE-6050227]) HSP 1 Score: 170.244 bits (430), Expect = 5.550e-43 Identity = 136/472 (28.81%), Postives = 230/472 (48.73%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSNHL---SNCKHKKFSLKVKRKE----NIFEGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VE PR++ + G ++GIQG NSCY+D++ F +F+F + DS+ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++I+ L+ +C C ++ + C C+ + +F C+ + +H KF+ KE + G + +++LFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G+Y + E+ LDS ++ R+ A++C Y++PT+ Y
Sbjct: 423 GVIRWIGQPAGVNEMLAGLELEDECAGCTDGTFKGTRYFTCAPKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEGNTPPRTEKEGLEVMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDSVLLRPKEKTDVEYYSETQALLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKIRSAGQKV-QDCYFYQIF-MDKNENVGVPTIQQLLEWSFINSSLKFAEAPSCLIVQMPRFGKDFKMFNKIFPSLDLNITDLLEDTPRQCRICGGLAMYECRECYDDPDITAGKIKQFCKICNTQVHLHPKRQHHKFNPVSLPKELPDWDWRHGCIPYQKMDLFAVLCIETSHYVAFVKYGRDDSSWVFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEELHALDSRNIQGCARRLLCDAYMCMYQSPTMSLY 892
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Xenopus
Match: tril (TLR4 interactor with leucine-rich repeats [Source:Xenbase;Acc:XB-GENE-6050227]) HSP 1 Score: 169.088 bits (427), Expect = 6.503e-43 Identity = 119/390 (30.51%), Postives = 202/390 (51.79%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSNHL---SNCKHKKFSLKVKRKE----NIFEGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRET----DIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+VE PR++ + G ++GIQG NSCY+D++ F +F+F + DS+ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++I+ L+ +C C ++ + C C+ + +F C+ + +H KF+ KE + G + +++LFA+LCIE +HYVA+VK G W+++DSMA D I + ++G+Y + E+ LDS ++ R+ A++C Y++PT+ Y
Sbjct: 384 SEVVEGNTPPRTEKEGLEVMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDSVLLRPKEKTDVEYYSETQALLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKIRSAGQKV-QDCYFYQIF-MDKNENVGVPTIQQLLEWSFINSSLKFAEAPSCLIVQMPRFGKDFKMFNKIFPSLDLNITDLLEDTPRQCRICGGLAMYECRECYDDPDITAGKIKQFCKICNTQVHLHPKRQHHKFNPVSLPKELPDWDWRHGCIPYQKMDLFAVLCIETSHYVAFVKYGRDDSSWVFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEELHALDSRNIQGCARRLLCDAYMCMYQSPTMSLY 771
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Xenopus
Match: tril (TLR4 interactor with leucine-rich repeats [Source:Xenbase;Acc:XB-GENE-6050227]) HSP 1 Score: 169.474 bits (428), Expect = 9.975e-43 Identity = 136/472 (28.81%), Postives = 230/472 (48.73%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSNHL---SNCKHKKFSLKVKRKE----NIFEGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VE PR++ + G ++GIQG NSCY+D++ F +F+F + DS+ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++I+ L+ +C C ++ + C C+ + +F C+ + +H KF+ KE + G + +++LFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G+Y + E+ LDS ++ R+ A++C Y++PT+ Y
Sbjct: 505 GVIRWIGQPAGVNEMLAGLELEDECAGCTDGTFKGTRYFTCAPKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEGNTPPRTEKEGLEVMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDSVLLRPKEKTDVEYYSETQALLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKIRSAGQKV-QDCYFYQIF-MDKNENVGVPTIQQLLEWSFINSSLKFAEAPSCLIVQMPRFGKDFKMFNKIFPSLDLNITDLLEDTPRQCRICGGLAMYECRECYDDPDITAGKIKQFCKICNTQVHLHPKRQHHKFNPVSLPKELPDWDWRHGCIPYQKMDLFAVLCIETSHYVAFVKYGRDDSSWVFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEELHALDSRNIQGCARRLLCDAYMCMYQSPTMSLY 974
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Xenopus
Match: tril (TLR4 interactor with leucine-rich repeats [Source:Xenbase;Acc:XB-GENE-6050227]) HSP 1 Score: 169.474 bits (428), Expect = 1.162e-42 Identity = 136/472 (28.81%), Postives = 230/472 (48.73%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSNHL---SNCKHKKFSLKVKRKE----NIFEGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VE PR++ + G ++GIQG NSCY+D++ F +F+F + DS+ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++I+ L+ +C C ++ + C C+ + +F C+ + +H KF+ KE + G + +++LFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G+Y + E+ LDS ++ R+ A++C Y++PT+ Y
Sbjct: 487 GVIRWIGQPAGVNEMLAGLELEDECAGCTDGTFKGTRYFTCAPKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEGNTPPRTEKEGLEVMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDSVLLRPKEKTDVEYYSETQALLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKIRSAGQKV-QDCYFYQIF-MDKNENVGVPTIQQLLEWSFINSSLKFAEAPSCLIVQMPRFGKDFKMFNKIFPSLDLNITDLLEDTPRQCRICGGLAMYECRECYDDPDITAGKIKQFCKICNTQVHLHPKRQHHKFNPVSLPKELPDWDWRHGCIPYQKMDLFAVLCIETSHYVAFVKYGRDDSSWVFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEELHALDSRNIQGCARRLLCDAYMCMYQSPTMSLY 956
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Xenopus
Match: tril (TLR4 interactor with leucine-rich repeats [Source:Xenbase;Acc:XB-GENE-6050227]) HSP 1 Score: 140.584 bits (353), Expect = 1.414e-33 Identity = 126/480 (26.25%), Postives = 213/480 (44.38%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFL--------INKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSNHL---SNCKHKKFSLKVKRKE----NIFEGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VE PR++ + G ++GIQG NSCY+D++ F +F+F + DS+ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE F+ LF+ + I L T + G L + + P CLI+Q+PR G +K F+++ ++I+ L+ +C C ++ + C C+ + +F C+ + +H KF+ KE + G + +++LFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G+Y + E+ LDS ++ R+ A++C Y++PT+ Y
Sbjct: 504 GVIRWIGQPAGVNEMLAGLELEDECAGCTDGTFKGTRYFTCAPKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEGNTPPRTEKEGLEVMIGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDSVLLRPKEKTDVEYYSETQALLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEE-----------------------------FLNILFH------HILRNIESKLSVTDICAGLLWVTLNIELVCEAPSCLIVQMPRFGKDFKMFNKIFPSLDLNITDLLEDTPRQCRICGGLAMYECRECYDDPDITAGKIKQFCKICNTQVHLHPKRQHHKFNPVSLPKELPDWDWRHGCIPYQKMDLFAVLCIETSHYVAFVKYGRDDSSWVFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEELHALDSRNIQGCARRLLCDAYMCMYQSPTMSLY 948
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Mouse
Match: Cyld (CYLD lysine 63 deubiquitinase [Source:MGI Symbol;Acc:MGI:1921506]) HSP 1 Score: 166.777 bits (421), Expect = 2.780e-42 Identity = 118/390 (30.26%), Postives = 197/390 (50.51%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 382 SEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 769
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Mouse
Match: Cyld (CYLD lysine 63 deubiquitinase [Source:MGI Symbol;Acc:MGI:1921506]) HSP 1 Score: 167.933 bits (424), Expect = 2.782e-42 Identity = 136/472 (28.81%), Postives = 224/472 (47.46%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 485 GVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 954
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Mouse
Match: Cyld (CYLD lysine 63 deubiquitinase [Source:MGI Symbol;Acc:MGI:1921506]) HSP 1 Score: 167.933 bits (424), Expect = 2.811e-42 Identity = 136/472 (28.81%), Postives = 224/472 (47.46%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 482 GVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 951
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Mouse
Match: Cyld (CYLD lysine 63 deubiquitinase [Source:MGI Symbol;Acc:MGI:1921506]) HSP 1 Score: 167.933 bits (424), Expect = 2.811e-42 Identity = 136/472 (28.81%), Postives = 224/472 (47.46%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 482 GVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 951
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Mouse
Match: Cyld (CYLD lysine 63 deubiquitinase [Source:MGI Symbol;Acc:MGI:1921506]) HSP 1 Score: 167.933 bits (424), Expect = 2.811e-42 Identity = 136/472 (28.81%), Postives = 224/472 (47.46%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 482 GVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 951
BLAST of CYLD lysine 63 deubiquitinase vs. UniProt/SwissProt
Match: sp|Q5RED8|CYLD_PONAB (Ubiquitin carboxyl-terminal hydrolase CYLD OS=Pongo abelii OX=9601 GN=CYLD PE=2 SV=1) HSP 1 Score: 169.474 bits (428), Expect = 5.002e-42 Identity = 135/472 (28.60%), Postives = 225/472 (47.67%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 486 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 955
BLAST of CYLD lysine 63 deubiquitinase vs. UniProt/SwissProt
Match: sp|Q9NQC7|CYLD_HUMAN (Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens OX=9606 GN=CYLD PE=1 SV=1) HSP 1 Score: 169.474 bits (428), Expect = 5.819e-42 Identity = 135/472 (28.60%), Postives = 225/472 (47.67%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + +ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 486 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 955
BLAST of CYLD lysine 63 deubiquitinase vs. UniProt/SwissProt
Match: sp|Q1RMU2|CYLD_BOVIN (Ubiquitin carboxyl-terminal hydrolase CYLD OS=Bos taurus OX=9913 GN=CYLD PE=2 SV=1) HSP 1 Score: 167.933 bits (424), Expect = 1.710e-41 Identity = 134/472 (28.39%), Postives = 226/472 (47.88%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G + + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + +D LDS + R+ A++C Y++PT+ Y
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGFEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLECSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNAQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLDDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. UniProt/SwissProt
Match: sp|Q66H62|CYLD_RAT (Ubiquitin carboxyl-terminal hydrolase CYLD OS=Rattus norvegicus OX=10116 GN=Cyld PE=1 SV=1) HSP 1 Score: 167.933 bits (424), Expect = 1.953e-41 Identity = 136/472 (28.81%), Postives = 224/472 (47.46%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 483 GVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHTYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. UniProt/SwissProt
Match: sp|Q80TQ2|CYLD_MOUSE (Ubiquitin carboxyl-terminal hydrolase CYLD OS=Mus musculus OX=10090 GN=Cyld PE=1 SV=2) HSP 1 Score: 167.933 bits (424), Expect = 1.966e-41 Identity = 136/472 (28.81%), Postives = 224/472 (47.46%), Query Frame = 1
Query: 1180 GVLCWMGFDKD-SSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN---------KFAYYCSN----HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S + L L + +G G + A K L V+ K P L+ NQ + SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + +F CS H H + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 482 GVIRWIGQPPGLSDVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHDILRVEPLLKIRSAGQKV-QDCNFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 951
BLAST of CYLD lysine 63 deubiquitinase vs. TrEMBL
Match: A0A2H1X3R6 (SFRICE_004358 OS=Spodoptera frugiperda OX=7108 GN=SFRICE_004358 PE=4 SV=1) HSP 1 Score: 179.104 bits (453), Expect = 8.300e-44 Identity = 133/461 (28.85%), Postives = 212/461 (45.99%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVE-PKCVVPVELKNKENQTYKSSEIVEEYQMPRSKIS-------------CGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLK------GDHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKF--AYYCSN-----HLSNCKHKKFSLKVKRK-ENIFEG----KVELELFAILCIEKTHYVAYVKTGEVLG---KWIYYDSMAKTDQSVLKPEIRE----TDIGKYFMSNKE----DDLDSEHVTRIKKFAFVCFYKNPTLEYY 2433
GV+ W+G D++ + L + +G G ++ A L V P C ++ + + E + P + G RGIQG NSCY+D + FAMF F +FD+L + H SE++ ++R IV PLRK+ YV +RV + R L L EKDPEE L L L +P LK + +G + C+ QLF + S + + ++L+++F G +++ P I+Q+PR G YK + +V+ P +D++ LI +C+ C +++ C AC + C N H + HK L + + NI E +V +ELFA+LCIE +HYVA+VK G +G W ++DSMA I E +++G + + D H R+ A++CFY++P + Y
Sbjct: 169 GVVRWIGVIDDTATA-GVELEQSVCGLGDGSRGGARLFSCAAGRALFVPLPLCRRDARFRDTPPPDHSDAHDAEHFDQPDCPVVPGVVPPLNSLGELAGKNRGIQGHHNSCYLDATLFAMFTFTSVFDALLYRPPEPEDSPHYSEVQRVLREEIVNPLRKHGYVRADRVMKLRTLLERLSDVPGLTSEEKDPEEFLNGLVAQLLRAEPFLK---LSSGQEAYCY--QLFVEKDEHVS-VPTVQQLLEQSFTTSGVKLSEVPAAFIIQMPRFGKQYKLYQKVIPSPLLDVTDLIEGLPRQCTVCGSLARWECAACAGSALEAGALCDNCRRVAHATRPHHKAVPLTINEEYANILESCPVPRVYMELFAVLCIETSHYVAFVKAG--VGHDAPWCFFDSMADRKGERNGYNIPEIVCISELGAWLGEDSRGAPPDRPLPAHARRLLADAYMCFYRSPDVAMY 620
BLAST of CYLD lysine 63 deubiquitinase vs. TrEMBL
Match: A0A4C1ZIM1 (Ubiquitin carboxyl-terminal hydrolase CYLD OS=Eumeta variegata OX=151549 GN=CYLD PE=4 SV=1) HSP 1 Score: 177.563 bits (449), Expect = 2.049e-43 Identity = 138/476 (28.99%), Postives = 227/476 (47.69%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQ--------TYKSSEIVEEYQMPRSKISCGI-------------ERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLK------GDHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFA-----YYCSN-----HLSNCKHKKFSLKVKRK-----ENIFEGKVELELFAILCIEKTHYVAYVKTGEVL-GKWIYYDSMAKTDQSVLK-----PEIR-ETDIGKYFMSNKEDDLD---------SEHVTRIKKFAFVCFYKNPTLEYY 2433
GV+ W+G +DS + + L E +G+ GQ++ A L V P+ L ++++ T+ S+ ++++ P + G+ RGIQG NSCY+D + FAMF F +FD+L + H +E++ ++R IV PLR++ YV +RV + R L L EKDPEE L L L +P LK + +G + C+ QLF + S + + ++L+++F G +++ P LI+Q+PR G YK + +L P +D++ LI +C+ C ++ C AC A +C++ H S HK +L+V + E+ +V +ELFA+LCIE +HYVA+VK G+ W ++DSMA D+ K PEI ++G + L+ H R+ A++CFY++P + Y
Sbjct: 120 GVIRWIGLSEDSVMA-GVELEESVPGLGDGVRGGQQLFACAPGRALFV------PLALCRRDSRFRDTPPPDTHDLSD-QQQFEQPECPVVTGVVAPLNALGELAGKNRGIQGHHNSCYLDATLFAMFTFTSVFDALLYRPQEPEDSPHYTEVQRVLREEIVNPLRRHGYVRADRVMKLRTLLERLSDVPGLTCEEKDPEEFLNGLVAQLLRAEPFLK---LSSGQESFCY--QLFVEKDEHAS-LPSVQQLLEQSFATSGVKLSEVPAALIIQMPRFGKQYKLYPRLLPSPLLDVTDLIESLPRQCTVCGGLARWECAACAGRCGAGLESTAFCNSCLRVAHASRTHHKATALEVCEEFATVLESCPVPRVYMELFAVLCIETSHYVAFVKAGDGHDSPWCFFDSMA--DRKGEKNGYNIPEIVCLEELGAWLSEEGARALNDAAPSDRQLPPHAKRLLCDAYMCFYRSPDVAMY 579
BLAST of CYLD lysine 63 deubiquitinase vs. TrEMBL
Match: A0A3B3QIZ4 (Cylindromatosis (turban tumor syndrome), a OS=Paramormyrops kingsleyae OX=1676925 PE=3 SV=1) HSP 1 Score: 176.022 bits (445), Expect = 1.330e-41 Identity = 135/473 (28.54%), Postives = 225/473 (47.57%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYF-LRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVK-------RKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S L L E +G G + K L V+ +C P L N N + SE+V E PR++ I G ++GIQG NSCY+D++ F +F+F + D++ L+ ++ E + ++R+ IV PLR + YV +V + R+ L + F EKDPEE L LF+ + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ L V R++ IF + ++LFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G Y E+ +LD + + R+ A++C Y++PT+ Y
Sbjct: 455 GVIRWVGQPPGLSEPLAGLELEEECVGCTDGTFKGTRYFSCPPKKALFVKLRCCRPDSRFSSLHNPPNPIERCNSIAFGSYLSEVVHENTPPRTENEGLEIMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRAKTDVEYYKETQELLRTEIVNPLRIHGYVCATKVMKLRRILEKVEAASGFTSEEKDPEEFLNILFYHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKEKVGVPTIQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLAYYECRECYEDTDITAGKIKQFCETCNTQVHLHPRRKAHRHGRLSVPRELQEGVRRQGIFP-RQRMQLFAVLCIETSHYVAFVKYGAAESAWLFFDSMADRDGGQNGFNIPQVSPCPEVGAYLKMTPEELHELDPKSIQGFARRLLCDAYMCMYQSPTMSLY 924
BLAST of CYLD lysine 63 deubiquitinase vs. TrEMBL
Match: A0A3B3QI36 (Cylindromatosis (turban tumor syndrome), a OS=Paramormyrops kingsleyae OX=1676925 PE=3 SV=1) HSP 1 Score: 176.022 bits (445), Expect = 1.436e-41 Identity = 135/473 (28.54%), Postives = 225/473 (47.57%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYF-LRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVK-------RKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G S L L E +G G + K L V+ +C P L N N + SE+V E PR++ I G ++GIQG NSCY+D++ F +F+F + D++ L+ ++ E + ++R+ IV PLR + YV +V + R+ L + F EKDPEE L LF+ + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ L V R++ IF + ++LFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G Y E+ +LD + + R+ A++C Y++PT+ Y
Sbjct: 494 GVIRWVGQPPGLSEPLAGLELEEECVGCTDGTFKGTRYFSCPPKKALFVKLRCCRPDSRFSSLHNPPNPIERCNSIAFGSYLSEVVHENTPPRTENEGLEIMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRAKTDVEYYKETQELLRTEIVNPLRIHGYVCATKVMKLRRILEKVEAASGFTSEEKDPEEFLNILFYHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKEKVGVPTIQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLAYYECRECYEDTDITAGKIKQFCETCNTQVHLHPRRKAHRHGRLSVPRELQEGVRRQGIFP-RQRMQLFAVLCIETSHYVAFVKYGAAESAWLFFDSMADRDGGQNGFNIPQVSPCPEVGAYLKMTPEELHELDPKSIQGFARRLLCDAYMCMYQSPTMSLY 963
BLAST of CYLD lysine 63 deubiquitinase vs. TrEMBL
Match: A0A2K6NCB8 (CYLD lysine 63 deubiquitinase OS=Rhinopithecus roxellana OX=61622 GN=CYLD PE=3 SV=1) HSP 1 Score: 169.474 bits (428), Expect = 1.630e-41 Identity = 118/390 (30.26%), Postives = 199/390 (51.03%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG------DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEGK------VELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+VEE P+ + I G ++GIQG NSCY+D++ F +FAF + D++ L+ ++ SE + ++R+ IV PLR Y YV ++ + RK L + F EKDPEE L LFH + +PLLK + V Q C+ Q+F M + + I ++L+ +F+ + P CLI+Q+PR G +K F ++ +++I+ L+ +C C ++ + C C+ + K +C H HK + + + ++ + ++ELFA+LCIE +HYVA+VK G+ W+++DSMA D P++ ++G+Y + ED LDS + R+ A++C Y++PT+ Y
Sbjct: 78 SEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKV-QDCYFYQIF-MEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLY 465
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Cavefish
Match: cylda (CYLD lysine 63 deubiquitinase [Source:NCBI gene;Acc:103044817]) HSP 1 Score: 166.777 bits (421), Expect = 2.056e-42 Identity = 114/390 (29.23%), Postives = 203/390 (52.05%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEI------RNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-----HL----SNCKHKKFSLKVKRKENIF-EGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD---QSVLKPEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ +++ + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C HL ++ K S+ + +E ++ +G ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 377 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKSKTDVEYYLETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKDKVLVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLALYECRECYEDADITAGKIKQFCEKCNTQVHLHPRRKTHRYGKLSVPKELQEGVWRQGSFPHQQMELFAVLCIETSHYVAFVKYGAADSAWLFFDSMADRDGGQNGFNIPQVSPCPEVGAYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 764
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Cavefish
Match: cylda (CYLD lysine 63 deubiquitinase [Source:NCBI gene;Acc:103044817]) HSP 1 Score: 166.392 bits (420), Expect = 6.092e-42 Identity = 115/390 (29.49%), Postives = 201/390 (51.54%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNS------EIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHK--KFSLKVKRKENIF-EGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ + E + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ K S+ + +E ++ +G ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 565 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKSKTDVEYYLETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKDKVLVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLALYECRECYEDADITAGKIKQFCEKCNTQVHLHPRRKTHRYGKLSVPKELQEGVWRQGSFPHQQMELFAVLCIETSHYVAFVKYGAADSAWLFFDSMADRDGGQNGFNIPQVSPCPEVGAYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Cavefish
Match: cylda (CYLD lysine 63 deubiquitinase [Source:NCBI gene;Acc:103044817]) HSP 1 Score: 166.392 bits (420), Expect = 6.092e-42 Identity = 115/390 (29.49%), Postives = 201/390 (51.54%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNS------EIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHK--KFSLKVKRKENIF-EGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ + E + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ K S+ + +E ++ +G ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 565 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKSKTDVEYYLETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKDKVLVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLALYECRECYEDADITAGKIKQFCEKCNTQVHLHPRRKTHRYGKLSVPKELQEGVWRQGSFPHQQMELFAVLCIETSHYVAFVKYGAADSAWLFFDSMADRDGGQNGFNIPQVSPCPEVGAYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 952
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Cavefish
Match: cylda (CYLD lysine 63 deubiquitinase [Source:NCBI gene;Acc:103044817]) HSP 1 Score: 166.392 bits (420), Expect = 6.103e-42 Identity = 114/390 (29.23%), Postives = 202/390 (51.79%), Query Frame = 1
Query: 1384 SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEI------RNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHK--KFSLKVKRKENIF-EGKV---ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ +++ + ++R+ IV PLR + YV ++ + R+ L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+++ K +C H H+ K S+ + +E ++ +G ++ELFA+LCIE +HYVA+VK G W+++DSMA D P++ ++G Y E+ LD +++ R+ A++C Y++PT+ Y
Sbjct: 526 SEVVNENTPPRTENDGLEVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKSKTDVEYYLETQELLRTEIVNPLRIHGYVCATKIMKLRRILEKVEAASGFTSEEKDPEEFLNILFHHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKDKVLVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLALYECRECYEDADITAGKIKQFCEKCNTQVHLHPRRKTHRYGKLSVPKELQEGVWRQGSFPHQQMELFAVLCIETSHYVAFVKYGAADSAWLFFDSMADRDGGQNGFNIPQVSPCPEVGAYLKMTPEELHALDPKNIQGYARRLLCDAYMCMYQSPTMSLY 913
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Cavefish
Match: ENSAMXT00000022455.2 (pep primary_assembly:Astyanax_mexicanus-2.0:21:17282006:17293930:1 gene:ENSAMXG00000021802.2 transcript:ENSAMXT00000022455.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 153.295 bits (386), Expect = 8.160e-38 Identity = 119/394 (30.20%), Postives = 190/394 (48.22%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFD-SLFLKGDHNS----EIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFY---------------------------MNEPSTS--KISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-----HLSNCKHKKFSLKVKRKENIFEGKV-----ELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKT---DQSVLKPEIRE-TDIGKYF-MSNKE-DDLDS----EHVTRIKKFAFVCFYKNPTLEYY 2433
G ++GIQG NSCY+D S F++F+ D LF +S + + ++R IV PLR+Y YV ++ RK L F + EKDPEE L LF LL +PLLK ++ Q C + QLF ++ P+ +++ + +L+ +F+ G + P CL L +PR G +K F +L K+DI+ L+ +CS C +++ CL C+++ + YC+ H + LKV+ + +EG V +L+LFA+ CIE +HYV++VK G + W+++DSMA + P++R ++G+Y +S KE LD+ E V R+ A++C Y P L Y
Sbjct: 573 GFKKGIQGHLNSCYLDASLFSLFSCCSSVDWVLFYPSSDDSHRSKDAQELLRCEIVNPLRRYGYVCASKTMALRKLLEAETTDAGFTNEEKDPEEFLNKLFQLLR-VEPLLKIRSMSQ-EPQECHIYQLFPPSISSSPSSPLHSPLSPSLSNSLSPIPLSSPAAGLMRVASVQALLESSFIHSGLKFTEAPSCLPLLMPRFGKEFKMFDTILPSLKLDITDLLDETLRQCSICQSVAAWECLQCYEDLDITPGQLKQYCNTCNAQVHAHKKRQTHSPLKVRIPKGTWEGPVHGARQQLDLFAVTCIETSHYVSFVKYGPLQTDWLFFDSMADREGGENGFNVPQVRACPEVGRYLSLSEKELGRLDTTSLKEPVRRLLCDAYMCLYHCPELSLY 964
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000692.1 (pep scaffold:Pmarinus_7.0:GL491130:1075:4385:-1 gene:ENSPMAG00000000632.1 transcript:ENSPMAT00000000692.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 72.7886 bits (177), Expect = 1.386e-14 Identity = 37/101 (36.63%), Postives = 58/101 (57.43%), Query Frame = 1
Query: 1375 YKSSEIVEEYQMPRSK----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRN------IMRSRIVYPLRKYEYVSFNRVSEFRKEL 1647
Y+S + E P K + CG +GIQG NSCY+D++ F MFAF +FD + + +S++++ ++R IV PLRK +VS +V + RK+L
Sbjct: 118 YRSERVEGEVPPPSEKEATAVVCGRTKGIQGHYNSCYLDSTLFCMFAFSTVFDGMLHRPQRSSDLKDYNTVQQLLREDIVNPLRKNGFVSATKVMQLRKQL 218
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Nematostella
Match: EDO47295 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM7]) HSP 1 Score: 120.553 bits (301), Expect = 8.364e-29 Identity = 101/367 (27.52%), Postives = 177/367 (48.23%), Query Frame = 1
Query: 1426 SCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSE------IRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECS-TISNHICLACHKNK-----FAYYCSN-------HLSNCKHKKFSLKVKRKENIF---EGKVE---LELFAILCIEKTHYVAYVKTGEVL-GKWIYYDSMAKT---DQSVLKPEIRETDIGKYFMSNKEDDLDSE--------HVTRIKKFAFVCFYKN 2415
S G+ RGIQG NSCY+D++ ++MFAF +FD+L + +S+ ++ +++ IV PLR+ +V +RV R+ L L EKDPEE L TL H + + LL+ ++S + + +E K++ + +++++F+ + + P CLILQ+PR G YK + + +DI+ ++ C C S C C++ K +C + H HK + V R+ + + +G +E +ELFA++CI+ +HYVA+VK G+ W ++DSMA P +R ++ K D++ ++ R+ A++C Y+N
Sbjct: 112 STGMMRGIQGHHNSCYLDSTLYSMFAFTTVFDTLLHRERQSSDLEDYDKVQKVLKEEIVNPLRRNGFVRADRVLRLRRLLDKLGSTSGLTDEEKDPEEFLNTLLHQVLKSESLLQ-LKSHGRCEESNYYQIITEKDE--GIKLATVQTLIEQSFMAADLKLAEVPSCLILQMPRFGNKYKMYDIIFPNTTLDITDILDNVPRPCVLCGEQASTFECKECYEEKIFSIGITSFCRDCCKKVHSHPRRTSHKLTPIIVPREYSQYARRDGPLERYTMELFAVVCIQTSHYVAFVKCGQGPDAPWCFFDSMADRKGESNGYNIPAVRACPEASRWLLAKPDEIIGANRRGELPGNMKRLFGDAYMCMYQN 475
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Medaka
Match: cylda (CYLD lysine 63 deubiquitinase [Source:NCBI gene;Acc:101156964]) HSP 1 Score: 165.622 bits (418), Expect = 1.056e-41 Identity = 131/472 (27.75%), Postives = 220/472 (46.61%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYF-LRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEI------RNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEG------KVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLK---PEIRE-TDIGKYFMSNKED--DLDSEHVT----RIKKFAFVCFYKNPTLEYY 2433
GV+ W+G L L E +G G + K L V+ KC P L + N + SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ +++ + ++R+ IV PLR + YV +V + R+ L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+ + K +C H H+ L V ++ G + +ELFA+LCIE +HYVA+VK G W+++DSMA D P++ ++ Y + E+ LD + + R+ A++C Y++PT+ Y
Sbjct: 448 GVIRWVGLPPGLLEPLAGLELEEECPGCTDGTFKGTRYFTCPPKKALFVKLKCCRPDSRFPSLHHSPNPIERCNSIAFGGYLSEVVHENTPPRTENDGLDVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPQSKTDVEYYRETQELLRTEIVNPLRIHGYVCATKVMKLRRILEKVEAASGFTSEEKDPEEFLIILFHHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKDKVGVPTIQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLAFYECRDCYDDGDITAGKIKQFCEKCNTQVHLHPKRKAHRHGKLSVPKELQEGTGRQGGFPRQRMELFAVLCIETSHYVAFVKYGTADSAWLFFDSMADRDGGQNGFNIPQVSPCPEVETYLKMSPEELHTLDPKSIQGQARRLLCDAYMCMYQSPTMSLY 917
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Medaka
Match: cylda (CYLD lysine 63 deubiquitinase [Source:NCBI gene;Acc:101156964]) HSP 1 Score: 160.229 bits (404), Expect = 5.435e-40 Identity = 121/413 (29.30%), Postives = 195/413 (47.22%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYF--LRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVP----VELKNKENQTYKS---------SEIVEEYQMPRSK-----ISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNS------EIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKN------KFAYYCSN-------HLSNCKHKKFSLKVKRKENIFEG------KVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTD 2283
GV+ W+G L+ L L E +G G + K L V+ KC P L + N + SE+V E PR++ + G ++GIQG NSCY+D++ F +F+F + D++ L+ + E + ++R+ IV PLR + YV +V + R+ L + F EKDPEE L LFH + DPLLK + V Q C+ Q+F M++ + I ++L+ +F+ + P CLI+Q+PR G +K F+++ ++DI+ L+ +C C ++ + C C+ + K +C H H+ L V ++ G + +ELFA+LCIE +HYVA+VK G W+++DSMA D
Sbjct: 487 GVIRWVGLPP-GLLEPLAGLELEEECPGCTDGTFKGTRYFTCPPKKALFVKLKCCRPDSRFPSLHHSPNPIERCNSIAFGGYLSEVVHENTPPRTENDGLDVMVGKKKGIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPQSKTDVEYYRETQELLRTEIVNPLRIHGYVCATKVMKLRRILEKVEAASGFTSEEKDPEEFLIILFHHILRVDPLLKLRSAGQKV-QDCYFYQIF-MDKKDKVGVPTIQQLLEWSFINSDLKFAEAPSCLIIQMPRFGKDFKMFNKIFPSLELDITDLLEDTPRECRICGGLAFYECRDCYDDGDITAGKIKQFCEKCNTQVHLHPKRKAHRHGKLSVPKELQEGTGRQGGFPRQRMELFAVLCIETSHYVAFVKYGTADSAWLFFDSMADRD 896
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Medaka
Match: cyldl (ubiquitin carboxyl-terminal hydrolase CYLD [Source:NCBI gene;Acc:101168449]) HSP 1 Score: 142.124 bits (357), Expect = 1.816e-34 Identity = 95/302 (31.46%), Postives = 152/302 (50.33%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG--DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNK------FAYYCS-------NHLSNCKHKKFSLKVKRKENIFEG------KVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMA 2274
G +GIQG NSCYMD + F++F+ DS+ K ++ I+ + IV PLR +V V + R+ L ++F EKDPEE L + H + DPLLK G Q + Q+F +++ + + ++L+ +F G + + P CLILQ+PR G +K F +++ ++DI+ L+ G +C C ++ C C K+ F +C +H H+ +L++ K + G + LELFA+LCIE +HYV++VK G WI++DSMA
Sbjct: 408 GRMKGIQGHCNSCYMDAALFSLFSCSSAMDSMLFKTTTSQDAPIQKTLLRDIVVPLRSKGFVECQHVMKLRQLLQKHGYSRSFTTEEKDPEEFLIVVMHHILALDPLLKLSA--AGKVQESYCYQIF-LDQNHCLVLPTVQQLLEHSFHSAGLRLAEVPSCLILQMPRFGKKFKMFDKIIPSLELDITDLLSEGPQQCIMCGNLAVEECADCFKDPTFSLTGFKIFCKKCSAQVHSHPKRRSHQPTALEIP-KGYMGRGIPHTLTRDRLELFAVLCIETSHYVSFVKHGPKSHDWIFFDSMA 705
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Medaka
Match: cyldl (ubiquitin carboxyl-terminal hydrolase CYLD [Source:NCBI gene;Acc:101168449]) HSP 1 Score: 142.124 bits (357), Expect = 1.895e-34 Identity = 95/302 (31.46%), Postives = 152/302 (50.33%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG--DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNK------FAYYCS-------NHLSNCKHKKFSLKVKRKENIFEG------KVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMA 2274
G +GIQG NSCYMD + F++F+ DS+ K ++ I+ + IV PLR +V V + R+ L ++F EKDPEE L + H + DPLLK G Q + Q+F +++ + + ++L+ +F G + + P CLILQ+PR G +K F +++ ++DI+ L+ G +C C ++ C C K+ F +C +H H+ +L++ K + G + LELFA+LCIE +HYV++VK G WI++DSMA
Sbjct: 408 GRMKGIQGHCNSCYMDAALFSLFSCSSAMDSMLFKTTTSQDAPIQKTLLRDIVVPLRSKGFVECQHVMKLRQLLQKHGYSRSFTTEEKDPEEFLIVVMHHILALDPLLKLSA--AGKVQESYCYQIF-LDQNHCLVLPTVQQLLEHSFHSAGLRLAEVPSCLILQMPRFGKKFKMFDKIIPSLELDITDLLSEGPQQCIMCGNLAVEECADCFKDPTFSLTGFKIFCKKCSAQVHSHPKRRSHQPTALEIP-KGYMGRGIPHTLTRDRLELFAVLCIETSHYVSFVKHGPKSHDWIFFDSMA 705
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Medaka
Match: cyldl (ubiquitin carboxyl-terminal hydrolase CYLD [Source:NCBI gene;Acc:101168449]) HSP 1 Score: 142.124 bits (357), Expect = 1.895e-34 Identity = 95/302 (31.46%), Postives = 152/302 (50.33%), Query Frame = 1
Query: 1432 GIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKG--DHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNK------FAYYCS-------NHLSNCKHKKFSLKVKRKENIFEG------KVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMA 2274
G +GIQG NSCYMD + F++F+ DS+ K ++ I+ + IV PLR +V V + R+ L ++F EKDPEE L + H + DPLLK G Q + Q+F +++ + + ++L+ +F G + + P CLILQ+PR G +K F +++ ++DI+ L+ G +C C ++ C C K+ F +C +H H+ +L++ K + G + LELFA+LCIE +HYV++VK G WI++DSMA
Sbjct: 408 GRMKGIQGHCNSCYMDAALFSLFSCSSAMDSMLFKTTTSQDAPIQKTLLRDIVVPLRSKGFVECQHVMKLRQLLQKHGYSRSFTTEEKDPEEFLIVVMHHILALDPLLKLSA--AGKVQESYCYQIF-LDQNHCLVLPTVQQLLEHSFHSAGLRLAEVPSCLILQMPRFGKKFKMFDKIIPSLELDITDLLSEGPQQCIMCGNLAVEECADCFKDPTFSLTGFKIFCKKCSAQVHSHPKRRSHQPTALEIP-KGYMGRGIPHTLTRDRLELFAVLCIETSHYVSFVKHGPKSHDWIFFDSMA 705
BLAST of CYLD lysine 63 deubiquitinase vs. Planmine SMEST
Match: SMESG000015653.1 (SMESG000015653.1) HSP 1 Score: 1580.46 bits (4091), Expect = 0.000e+0 Identity = 788/813 (96.92%), Postives = 799/813 (98.28%), Query Frame = 1
Query: 22 MSDNDLNNFGTIIPSKVIKVNIKTNELKDKLVVFQPKNITYKGIVKWYGQINDNDAYGIETDPIEFGTKGEFNGHNIFSSKSECGVLIKDNGKLLVNEQCGSICKSHCEDFKDDYQTEYSDTDFVVVRFVNALKIGKILNYGEINGIFCYKLKTIEDSQIYVFIKNDVLGKFANNDGIVKSFNDGIFDAIKSPEVFKAEIGQKIRFKCNNKYETGVLKWKGKIDNLKCIGILPDSADLTNDFRKQFPNENDTFWTLICLDMLGADKSLLYEISDPNICKIFNYFKISAFVNILNTKESYETVDGTVEAYLTDGREFFYEVKVHGNEIIIAKYDDVKCGFTGLSQQGNKAFKEITDPNSFGIITQLKKDDNVKIYPDDKNKLVSVCDGVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRSKISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKFAYYCSNHLSNCKHKKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDIGKYFMSNKEDDLDSEHVTRIKKFAFVCFYKNPTLEYYSQDFNHVNK 2460
MSDNDLNN GTIIPSKVI N K NELKDK VVFQPKNITYKGIVKWYGQINDNDAYGIETDPIEFGTKGEFNGHNIFSSKSECGVLIKDNGKLLVNEQCGSICKSHCEDFKD+YQTEYSDTDFVVVRFVNALKIGKIL YGEINGIFCYKLK IEDSQIYVFIKNDVLGKFAN+DGIVKSFNDGIFDAIKSPEVF AEIGQKIRFKCNNKYETGVLKWKGKIDNLKCIGILPDSADLTNDFRKQFPNEND FWTLICLDMLGADKSLLYEISDPNICKIFNYFKISAFVNILNTKESYETVDGTVEAYLTDGREFFYEVKVHGNEIIIAKYDDVKCGFTG++Q+GNKAF+EITDPNSFGIITQLKKDD VKIYPDDKNKLVSVCDGVLCWMGFDKDSSLKYFLRLNEPNEHGNNG+VFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRSKISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPEELLETLFHLLTPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECS ISNHICLACHK+KFA+YCSNHLSNCKHKK+ LK+K KENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDIGKYFMSNKEDDLDSEHVTRIKKFAFVCFYKNPTLEYYSQDFNHVNK
Sbjct: 1 MSDNDLNNIGTIIPSKVINFNNKANELKDKFVVFQPKNITYKGIVKWYGQINDNDAYGIETDPIEFGTKGEFNGHNIFSSKSECGVLIKDNGKLLVNEQCGSICKSHCEDFKDEYQTEYSDTDFVVVRFVNALKIGKILKYGEINGIFCYKLKIIEDSQIYVFIKNDVLGKFANDDGIVKSFNDGIFDAIKSPEVFIAEIGQKIRFKCNNKYETGVLKWKGKIDNLKCIGILPDSADLTNDFRKQFPNENDAFWTLICLDMLGADKSLLYEISDPNICKIFNYFKISAFVNILNTKESYETVDGTVEAYLTDGREFFYEVKVHGNEIIIAKYDDVKCGFTGINQRGNKAFEEITDPNSFGIITQLKKDDIVKIYPDDKNKLVSVCDGVLCWMGFDKDSSLKYFLRLNEPNEHGNNGIVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRSKISCGIERGIQGDKNSCYMDTSFFAMFAFQEIFDSLFLKGDHNSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPEELLETLFHLLTPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSNISNHICLACHKDKFAHYCSNHLSNCKHKKYRLKIK-KENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDIGKYFMSNKEDDLDSEHVTRIKKFAFVCFYKNPTLEYYSQDFNHVNK 812
BLAST of CYLD lysine 63 deubiquitinase vs. Planmine SMEST
Match: SMESG000007140.1 (SMESG000007140.1) HSP 1 Score: 133.265 bits (334), Expect = 6.751e-33 Identity = 113/404 (27.97%), Postives = 187/404 (46.29%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRS----KISCGIE--------RGIQGDKNSCYMDTSFFAMFAFQEIFDSLF--LKGDHNS-----EIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKF----AYYCSNHLSNCKHKKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDI 2322
G + W G D++ + L L++ G +G GQ++ N G+L L + T ++++V + +S +I CG+ +GIQG+ NSCY D++ FA+F ++ D L + +H + E R I+ +IVYPLRK +VSF+ E R + + ++ E + TL L PK+ LL NG + + QLF + S ++ EML+ + +Q + N+ P CLI+Q PR + L +I+IS + CS+C+ + C C +N+ + CS H C+H + K++ + KV +EL AI+CIEK H+V++VK E L T++ V K ++ DI
Sbjct: 44 GTVKWTGADENDCYFFGLELDDRISIGTDGTFGGQRLFTCQNGHGILAP--------LNTVASDTRFTAKVVSPENVKKSETSDQIVCGLNSIVIAGDNKGIQGNANSCYFDSALFALFVKSDVLDYLISPIINEHEADPITKEFREIIAWKIVYPLRKNGFVSFHYTQEMRNAIQKYGAKFAEMMKQETDMENVSTLLSKLCPKEQLLSIIP-HNGCQTNSMFMQLFLTVDNKVSFMTS-EEMLKISMVQNDIMFNELPTCLIMQAPRDAKGTNSYEYALPLNEIEISQICSNYLKNCSKCNGEAEFQCKKCLRNELDITCTFRCSQH--KCQHPACT-KLRPDTVKSKSKVFMELQAIICIEKCHFVSFVKQVERL-----------TNEQVEKLRAKQMDI 423
BLAST of CYLD lysine 63 deubiquitinase vs. Planmine SMEST
Match: SMESG000007140.1 (SMESG000007140.1) HSP 1 Score: 133.265 bits (334), Expect = 1.389e-32 Identity = 113/404 (27.97%), Postives = 187/404 (46.29%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRS----KISCGIE--------RGIQGDKNSCYMDTSFFAMFAFQEIFDSLF--LKGDHNS-----EIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKF----AYYCSNHLSNCKHKKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDI 2322
G + W G D++ + L L++ G +G GQ++ N G+L L + T ++++V + +S +I CG+ +GIQG+ NSCY D++ FA+F ++ D L + +H + E R I+ +IVYPLRK +VSF+ E R + + ++ E + TL L PK+ LL NG + + QLF + S ++ EML+ + +Q + N+ P CLI+Q PR + L +I+IS + CS+C+ + C C +N+ + CS H C+H + K++ + KV +EL AI+CIEK H+V++VK E L T++ V K ++ DI
Sbjct: 44 GTVKWTGADENDCYFFGLELDDRISIGTDGTFGGQRLFTCQNGHGILAP--------LNTVASDTRFTAKVVSPENVKKSETSDQIVCGLNSIVIAGDNKGIQGNANSCYFDSALFALFVKSDVLDYLISPIINEHEADPITKEFREIIAWKIVYPLRKNGFVSFHYTQEMRNAIQKYGAKFAEMMKQETDMENVSTLLSKLCPKEQLLSIIP-HNGCQTNSMFMQLFLTVDNKVSFMTS-EEMLKISMVQNDIMFNELPTCLIMQAPRDAKGTNSYEYALPLNEIEISQICSNYLKNCSKCNGEAEFQCKKCLRNELDITCTFRCSQH--KCQHPACT-KLRPDTVKSKSKVFMELQAIICIEKCHFVSFVKQVERL-----------TNEQVEKLRAKQMDI 423
BLAST of CYLD lysine 63 deubiquitinase vs. Planmine SMEST
Match: SMESG000056847.1 (SMESG000056847.1) HSP 1 Score: 130.954 bits (328), Expect = 9.760e-31 Identity = 116/408 (28.43%), Postives = 182/408 (44.61%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRS----KISCGIE--------RGIQGDKNSCYMDTSFFAMFAFQEIFDSLF------LKGDH-NSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKF----AYYCSNHLSNCKH----KKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDI 2322
G + W G D++ + L L++ G +G GQ++ N G+L L N + T ++++V + +S +I CG+ +GIQG+ NSCY D++ FA+F ++ D L + D E R I+ RIVYPLRK +VSF+ E R + + ++ E + TL L PK+ LL NG K + QLF + ++ EML+ + +Q + N+ P CLI+Q PR + L +I+IS + CS C+ + C C ++ + CS H C+H K VK K +F +EL AI+CIEK H+V++VK E L T++ V K ++ DI
Sbjct: 716 GTVKWTGVDENDCYFFGLELDDRINIGTDGTFGGQRLFTCQNGHGVLAP--------LNNVASDTRFTAKVVSPENVKKSETSDQIVCGLNSSVIAGDNKGIQGNANSCYFDSALFALFVKSDVLDYLISPIINEQEADPITKEFREIIAWRIVYPLRKNGFVSFHHTQEMRNVIQKYGAKFAEMMKQETDMENVSTLLSKLCPKEQLLSIIP-HNGCKTNSMFMQLFLTVDKKVPFMTS-EEMLKISMVQNDIMFNELPTCLIMQAPRDAKGTNSYKYALPLNEIEISQICSNYLKNCSICNGEAEFQCKTCLGDELDITCTFLCSQH--KCQHPACTKLLPDTVKSKSKVF-----MELQAIICIEKCHFVSFVKQVERL-----------TNEQVEKLRAKQMDI 1095
BLAST of CYLD lysine 63 deubiquitinase vs. Planmine SMEST
Match: SMESG000056847.1 (SMESG000056847.1) HSP 1 Score: 130.568 bits (327), Expect = 9.977e-31 Identity = 116/408 (28.43%), Postives = 182/408 (44.61%), Query Frame = 1
Query: 1180 GVLCWMGFDKDSSLKYFLRLNEPNEHGNNGLVFGQKIAEVANKCGLLVEPKCVVPVELKNKENQTYKSSEIVEEYQMPRS----KISCGIE--------RGIQGDKNSCYMDTSFFAMFAFQEIFDSLF------LKGDH-NSEIRNIMRSRIVYPLRKYEYVSFNRVSEFRKELGNLFPGKNFLHSEKDPXXXXXXXXXXXXPKDPLLKTFNIDNGVKQSCFMTQLFYMNEPSTSKISKISEMLQKTFLQGGFLINKPPKCLILQLPRHGTHYKQFSEVLIEPKIDISHLIRYGKNKCSECSTISNHICLACHKNKF----AYYCSNHLSNCKH----KKFSLKVKRKENIFEGKVELELFAILCIEKTHYVAYVKTGEVLGKWIYYDSMAKTDQSVLKPEIRETDI 2322
G + W G D++ + L L++ G +G GQ++ N G+L L N + T ++++V + +S +I CG+ +GIQG+ NSCY D++ FA+F ++ D L + D E R I+ RIVYPLRK +VSF+ E R + + ++ E + TL L PK+ LL NG K + QLF + ++ EML+ + +Q + N+ P CLI+Q PR + L +I+IS + CS C+ + C C ++ + CS H C+H K VK K +F +EL AI+CIEK H+V++VK E L T++ V K ++ DI
Sbjct: 618 GTVKWTGVDENDCYFFGLELDDRINIGTDGTFGGQRLFTCQNGHGVLAP--------LNNVASDTRFTAKVVSPENVKKSETSDQIVCGLNSSVIAGDNKGIQGNANSCYFDSALFALFVKSDVLDYLISPIINEQEADPITKEFREIIAWRIVYPLRKNGFVSFHHTQEMRNVIQKYGAKFAEMMKQETDMENVSTLLSKLCPKEQLLSIIP-HNGCKTNSMFMQLFLTVDKKVPFMTS-EEMLKISMVQNDIMFNELPTCLIMQAPRDAKGTNSYKYALPLNEIEISQICSNYLKNCSICNGEAEFQCKTCLGDELDITCTFLCSQH--KCQHPACTKLLPDTVKSKSKVF-----MELQAIICIEKCHFVSFVKQVERL-----------TNEQVEKLRAKQMDI 997 The following BLAST results are available for this feature:
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 3
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of CYLD lysine 63 deubiquitinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of CYLD lysine 63 deubiquitinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30027594 ID=SMED30027594|Name=CYLD lysine 63 deubiquitinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2506bpback to top protein sequence of SMED30027594-orf-1 >SMED30027594-orf-1 ID=SMED30027594-orf-1|Name=SMED30027594-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=814bp MSDNDLNNFGTIIPSKVIKVNIKTNELKDKLVVFQPKNITYKGIVKWYGQback to top Annotated Terms
The following terms have been associated with this transcript:
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