Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel

Overview


Name	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
Smed ID	SMED30027502
Length (bp)	213

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027502

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
parapharyngeal region	SMED30027502	h1SMcG0018092	SmedASXL_016339	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parapharyngeal region	SMED30027502	h1SMcG0018092	dd_Smed_v6_21440_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
parapharyngeal region	SMED30027502	h1SMcG0018092	dd_Smed_v6_13408_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
photoreceptor neuron	SMED30027502	h1SMcG0018092	SMED30004463	smed_20140614	PMID:22884275 Lapan et al., 2012
head region	SMED30027502	h1SMcG0018092	OX_Smed_1.0.20951	ox_Smed_v2	PMID:24238224 Kao et al., 2013
head region	SMED30027502	h1SMcG0018092	OX_Smed_1.0.20391	ox_Smed_v2	PMID:24238224 Kao et al., 2013

Note: Hover over icons to view figure legend

Homology

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BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Human
Match: HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [Source:HGNC Symbol;Acc:HGNC:4846])

HSP 1 Score: 59.3066 bits (142), Expect = 1.087e-11
Identity = 22/42 (52.38%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + IC L+ +MLLL HW+ CLQFL+PML ++P   WV
Sbjct:  359 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWV 400

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Human
Match: HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4 [Source:HGNC Symbol;Acc:HGNC:16882])

HSP 1 Score: 56.225 bits (134), Expect = 1.531e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  410 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWV 451

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Human
Match: HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3 [Source:HGNC Symbol;Acc:HGNC:19183])

HSP 1 Score: 55.8398 bits (133), Expect = 1.880e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  243 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWV 284

[Close]

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  243 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWV 284

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Human
Match: HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1 [Source:HGNC Symbol;Acc:HGNC:4845])

HSP 1 Score: 54.6842 bits (130), Expect = 5.914e-10
Identity = 20/42 (47.62%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+P+L ++P + WV
Sbjct:  290 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV 331

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
Match: Ih (gene:FBgn0263397 transcript:FBtr0290110)

HSP 1 Score: 70.4774 bits (171), Expect = 6.402e-16
Identity = 28/45 (62.22%), Postives = 36/45 (80.00%), Query Frame = 2

Query:   62 KFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            KFLNMAS F+ I  L+ +MLL+GHW+ CLQFL+PML  +P+ SWV
Sbjct:  931 KFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV 975

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
Match: Ih (gene:FBgn0263397 transcript:FBtr0100372)

HSP 1 Score: 70.4774 bits (171), Expect = 6.403e-16
Identity = 28/45 (62.22%), Postives = 36/45 (80.00%), Query Frame = 2

Query:   62 KFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            KFLNMAS F+ I  L+ +MLL+GHW+ CLQFL+PML  +P+ SWV
Sbjct:  936 KFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV 980

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
Match: Ih (gene:FBgn0263397 transcript:FBtr0100369)

HSP 1 Score: 68.5514 bits (166), Expect = 2.961e-15
Identity = 27/44 (61.36%), Postives = 35/44 (79.55%), Query Frame = 2

Query:   65 FLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            FLNMAS F+ I  L+ +MLL+GHW+ CLQFL+PML  +P+ SWV
Sbjct:  900 FLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV 943

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
Match: Ih (gene:FBgn0263397 transcript:FBtr0290109)

HSP 1 Score: 68.5514 bits (166), Expect = 2.961e-15
Identity = 27/44 (61.36%), Postives = 35/44 (79.55%), Query Frame = 2

Query:   65 FLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            FLNMAS F+ I  L+ +MLL+GHW+ CLQFL+PML  +P+ SWV
Sbjct:  905 FLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV 948

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
Match: Ih (gene:FBgn0263397 transcript:FBtr0290292)

HSP 1 Score: 62.003 bits (149), Expect = 5.884e-13
Identity = 27/44 (61.36%), Postives = 35/44 (79.55%), Query Frame = 2

Query:   65 FLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            FLNMAS F+ I  L+ +MLL+GHW+ CLQFL+PML  +P+ SWV
Sbjct:  211 FLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWV 254

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
Match: hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Source:ZFIN;Acc:ZDB-GENE-050420-360])

HSP 1 Score: 60.077 bits (144), Expect = 3.537e-12
Identity = 23/44 (52.27%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++PA+ WV K
Sbjct:  356 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVAK 399

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
Match: hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Source:ZFIN;Acc:ZDB-GENE-050420-360])

HSP 1 Score: 60.077 bits (144), Expect = 3.541e-12
Identity = 23/44 (52.27%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++PA+ WV K
Sbjct:  371 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVAK 414

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
Match: hcn4l (hyperpolarization activated cyclic nucleotide-gated potassium channel 4l [Source:ZFIN;Acc:ZDB-GENE-110411-3])

HSP 1 Score: 58.9214 bits (141), Expect = 9.197e-12
Identity = 22/44 (50.00%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV K
Sbjct:  151 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVAK 194

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
Match: hcn4l (hyperpolarization activated cyclic nucleotide-gated potassium channel 4l [Source:ZFIN;Acc:ZDB-GENE-110411-3])

HSP 1 Score: 58.9214 bits (141), Expect = 9.204e-12
Identity = 22/44 (50.00%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV K
Sbjct:  214 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVAK 257

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
Match: hcn3 (hyperpolarization activated cyclic nucleotide-gated potassium channel 3 [Source:ZFIN;Acc:ZDB-GENE-060503-193])

HSP 1 Score: 57.7658 bits (138), Expect = 2.880e-11
Identity = 21/47 (44.68%), Postives = 34/47 (72.34%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            ++AS  + I  L+ +MLLL HW+ C+QF++PML ++P+  WV K N+
Sbjct:  319 DLASAVVRIVNLIGMMLLLCHWDGCMQFMVPMLQDFPSTCWVSKNNM 365

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
Match: ENSXETT00000054879.1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [Source:NCBI gene;Acc:100495521])

HSP 1 Score: 56.6102 bits (135), Expect = 1.019e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  223 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWV 264

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
Match: ENSXETT00000054881.1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [Source:NCBI gene;Acc:100495521])

HSP 1 Score: 56.6102 bits (135), Expect = 1.019e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  237 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWV 278

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
Match: ENSXETT00000054883.1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [Source:NCBI gene;Acc:100495521])

HSP 1 Score: 56.6102 bits (135), Expect = 1.019e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  245 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWV 286

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
Match: ENSXETT00000054880.1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [Source:NCBI gene;Acc:100495521])

HSP 1 Score: 56.6102 bits (135), Expect = 1.020e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  270 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWV 311

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
Match: ENSXETT00000054882.1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [Source:NCBI gene;Acc:100495521])

HSP 1 Score: 56.6102 bits (135), Expect = 1.022e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  375 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWV 416

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Mouse
Match: Hcn2 (hyperpolarization-activated, cyclic nucleotide-gated K+ 2 [Source:MGI Symbol;Acc:MGI:1298210])

HSP 1 Score: 61.2326 bits (147), Expect = 1.722e-12
Identity = 22/42 (52.38%), Postives = 33/42 (78.57%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + IC L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  332 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWV 373

[Close]

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + IC L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  332 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWV 373

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Mouse
Match: Hcn3 (hyperpolarization-activated, cyclic nucleotide-gated K+ 3 [Source:MGI Symbol;Acc:MGI:1298211])

HSP 1 Score: 56.6102 bits (135), Expect = 6.705e-11
Identity = 21/42 (50.00%), Postives = 32/42 (76.19%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  242 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWV 283

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Mouse
Match: Hcn4 (hyperpolarization-activated, cyclic nucleotide-gated K+ 4 [Source:MGI Symbol;Acc:MGI:1298209])

HSP 1 Score: 56.225 bits (134), Expect = 1.011e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV
Sbjct:  410 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWV 451

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Mouse
Match: Hcn1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1 [Source:MGI Symbol;Acc:MGI:1096392])

HSP 1 Score: 54.6842 bits (130), Expect = 4.110e-10
Identity = 20/42 (47.62%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+P+L ++P + WV
Sbjct:  279 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV 320

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
Match: sp|Q9JKA9|HCN2_RAT (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Rattus norvegicus OX=10116 GN=Hcn2 PE=1 SV=3)

HSP 1 Score: 61.2326 bits (147), Expect = 1.204e-11
Identity = 22/42 (52.38%), Postives = 33/42 (78.57%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + IC L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  332 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWV 373

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
Match: sp|O88703|HCN2_MOUSE (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Mus musculus OX=10090 GN=Hcn2 PE=1 SV=1)

HSP 1 Score: 61.2326 bits (147), Expect = 1.204e-11
Identity = 22/42 (52.38%), Postives = 33/42 (78.57%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + IC L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  332 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWV 373

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
Match: sp|Q9UL51|HCN2_HUMAN (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens OX=9606 GN=HCN2 PE=1 SV=3)

HSP 1 Score: 59.3066 bits (142), Expect = 5.219e-11
Identity = 22/42 (52.38%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + IC L+ +MLLL HW+ CLQFL+PML ++P   WV
Sbjct:  359 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWV 400

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
Match: sp|O88705|HCN3_MOUSE (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 OS=Mus musculus OX=10090 GN=Hcn3 PE=1 SV=1)

HSP 1 Score: 56.6102 bits (135), Expect = 4.690e-10
Identity = 21/42 (50.00%), Postives = 32/42 (76.19%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  242 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWV 283

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
Match: sp|Q9JKA8|HCN3_RAT (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 OS=Rattus norvegicus OX=10116 GN=Hcn3 PE=1 SV=1)

HSP 1 Score: 56.6102 bits (135), Expect = 4.690e-10
Identity = 21/42 (50.00%), Postives = 32/42 (76.19%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV
Sbjct:  242 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWV 283

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
Match: A0A3Q0KQ67 (Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 1.602e-19
Identity = 37/56 (66.07%), Postives = 49/56 (87.50%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y+T  ++F+N+ASKF+GIC LVL+ML+LGHWNACLQFL+PMLM++P +SWV K  L
Sbjct:  410 YITQWEEFINIASKFMGICNLVLIMLILGHWNACLQFLVPMLMDFPVDSWVSKARL 465

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
Match: A0A504YD75 (Hyperpolarization activated cyclic nucleotide-gated potassium channel OS=Fasciola gigantica OX=46835 GN=FGIG_03579 PE=4 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 3.624e-19
Identity = 36/56 (64.29%), Postives = 49/56 (87.50%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y+T  ++ +N+A+KF+GIC LVL+MLLLGHWNACLQFL+PMLM++P +SWV K +L
Sbjct:  366 YITQWEEVVNIANKFMGICNLVLIMLLLGHWNACLQFLVPMLMDFPVQSWVSKAHL 421

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
Match: A0A4E0R7H0 (Hyperpolarization activated cyclic nucleotide-gated potassium channel OS=Fasciola hepatica OX=6192 GN=D915_004734 PE=4 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 3.624e-19
Identity = 36/56 (64.29%), Postives = 49/56 (87.50%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y+T  ++ +N+A+KF+GIC LVL+MLLLGHWNACLQFL+PMLM++P +SWV K +L
Sbjct:  366 YITQWEEVVNIANKFMGICNLVLIMLLLGHWNACLQFLVPMLMDFPVQSWVSKAHL 421

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
Match: A0A3R7FDZ8 (Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 OS=Clonorchis sinensis OX=79923 GN=HCN4 PE=4 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 5.192e-19
Identity = 36/56 (64.29%), Postives = 48/56 (85.71%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y+T  ++ +N+A+KF+GIC LVL+MLLLGHWNACLQFL+PMLM++P +SWV K  L
Sbjct:  335 YITQWEEVVNIANKFMGICNLVLIMLLLGHWNACLQFLVPMLMDFPVQSWVSKSQL 390

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
Match: A0A1S8WT36 (Uncharacterized protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_06667 PE=4 SV=1)

HSP 1 Score: 82.4185 bits (202), Expect = 7.172e-19
Identity = 36/52 (69.23%), Postives = 45/52 (86.54%), Query Frame = 2

Query:   56 PQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            P K +N+A+KF+GIC LVL+MLLLGHWNACLQFL+PMLM++P +SWV K  L
Sbjct:   38 PSKVVNIANKFMGICNLVLIMLLLGHWNACLQFLVPMLMDFPVQSWVSKSQL 89

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
Match: ENSAMXT00000011919.2 (pep primary_assembly:Astyanax_mexicanus-2.0:10:25443689:25475024:1 gene:ENSAMXG00000011501.2 transcript:ENSAMXT00000011919.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 60.077 bits (144), Expect = 3.275e-12
Identity = 23/47 (48.94%), Postives = 34/47 (72.34%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV K N+
Sbjct:  338 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPIDCWVYKNNM 384

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
Match: hcn4 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4-like [Source:NCBI gene;Acc:103046025])

HSP 1 Score: 59.6918 bits (143), Expect = 4.241e-12
Identity = 23/44 (52.27%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++PA+ WV K
Sbjct:    4 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVSK 47

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
Match: hcn4l (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like [Source:NCBI gene;Acc:103030119])

HSP 1 Score: 58.5362 bits (140), Expect = 1.112e-11
Identity = 22/44 (50.00%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV K
Sbjct:  358 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSK 401

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
Match: hcn4l (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like [Source:NCBI gene;Acc:103030119])

HSP 1 Score: 58.5362 bits (140), Expect = 1.113e-11
Identity = 22/44 (50.00%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P++ WV K
Sbjct:  379 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSK 422

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
Match: hcn3 (hyperpolarization activated cyclic nucleotide-gated potassium channel 3 [Source:ZFIN;Acc:ZDB-GENE-060503-193])

HSP 1 Score: 57.7658 bits (138), Expect = 1.943e-11
Identity = 23/47 (48.94%), Postives = 34/47 (72.34%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            ++AS  + I  L+ +MLLL HW+ CLQF++PML E+P+  WV K N+
Sbjct:  264 DLASAVVRIVNLIGMMLLLCHWDGCLQFMVPMLQEFPSNCWVSKNNM 310

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007865.1 (pep scaffold:Pmarinus_7.0:GL480431:10244:18565:-1 gene:ENSPMAG00000007113.1 transcript:ENSPMAT00000007865.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.7582 bits (125), Expect = 2.283e-10
Identity = 21/42 (50.00%), Postives = 31/42 (73.81%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML E+P + W+
Sbjct:  143 DLASAVVRIVNLIAMMLLLCHWDGCLQFLVPMLQEFPHDCWI 184

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Nematostella
Match: EDO49064 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI02])

HSP 1 Score: 60.077 bits (144), Expect = 1.325e-12
Identity = 26/56 (46.43%), Postives = 37/56 (66.07%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y+T  ++ LN+A   + I KL+  ML+L HWN C+QF +P L E+P +SWV   NL
Sbjct:  174 YMTRFEELLNIAKGQLRIMKLICCMLVLSHWNGCIQFFVPYLQEFPDDSWVSTSNL 229

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Nematostella
Match: EDO34316 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPS0])

HSP 1 Score: 53.5286 bits (127), Expect = 2.785e-10
Identity = 24/56 (42.86%), Postives = 34/56 (60.71%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y+   ++ LN+    I    LV ++LL+ HWN CLQFL+P L ++P  SWV   NL
Sbjct:  184 YVQQYEEILNVTRSVIRFINLVSIILLIAHWNGCLQFLVPYLQDFPETSWVSIHNL 239

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
Match: ENSORLT00000019259.2 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 [Source:NCBI gene;Acc:101159259])

HSP 1 Score: 60.077 bits (144), Expect = 3.227e-12
Identity = 22/44 (50.00%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++PA+ WV +
Sbjct:  368 DLASAMVRIMNLIAMMLLLCHWDGCLQFLVPMLQDFPADCWVTR 411

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
Match: hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Source:ZFIN;Acc:ZDB-GENE-050420-360])

HSP 1 Score: 59.6918 bits (143), Expect = 4.256e-12
Identity = 23/44 (52.27%), Postives = 33/44 (75.00%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++PA+ WV K
Sbjct:  373 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVSK 416

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
Match: ENSORLT00000019258.2 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [Source:NCBI gene;Acc:101172279])

HSP 1 Score: 57.3806 bits (137), Expect = 2.716e-11
Identity = 22/42 (52.38%), Postives = 32/42 (76.19%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWV 196
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML E+P++ WV
Sbjct:  531 DLASAVMRIFNLIGMMLLLCHWDGCLQFLVPMLQEFPSDCWV 572

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
Match: ENSORLT00000013376.2 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 [Source:NCBI gene;Acc:101158796])

HSP 1 Score: 57.3806 bits (137), Expect = 2.829e-11
Identity = 22/44 (50.00%), Postives = 32/44 (72.73%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV K
Sbjct:  247 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSK 290

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
Match: ENSORLT00000045599.1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 [Source:NCBI gene;Acc:101158796])

HSP 1 Score: 57.3806 bits (137), Expect = 2.835e-11
Identity = 22/44 (50.00%), Postives = 32/44 (72.73%), Query Frame = 2

Query:   71 NMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIK 202
            ++AS  + I  L+ +MLLL HW+ CLQFL+PML ++P + WV K
Sbjct:  380 DLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSK 423

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST
Match: SMESG000038954.1 (SMESG000038954.1)

HSP 1 Score: 150.984 bits (380), Expect = 3.353e-44
Identity = 66/66 (100.00%), Postives = 66/66 (100.00%), Query Frame = 2

Query:   14 KYLISTCDQGYLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            KYLISTCDQGYLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL
Sbjct:  536 KYLISTCDQGYLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 601

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST
Match: SMESG000038954.1 (SMESG000038954.1)

HSP 1 Score: 97.4413 bits (241), Expect = 1.956e-25
Identity = 50/56 (89.29%), Postives = 54/56 (96.43%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y++  ++FLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL
Sbjct:  466 YVSQWEEFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 521

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST
Match: SMESG000001696.1 (SMESG000001696.1)

HSP 1 Score: 92.8189 bits (229), Expect = 8.427e-24
Identity = 38/56 (67.86%), Postives = 50/56 (89.29%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y++  ++FLNMA+KF+GICKLVL+MLLL HWNACLQ+LIP+L ++PA+SWV KC L
Sbjct:  388 YVSQWEEFLNMANKFMGICKLVLMMLLLAHWNACLQYLIPVLNDFPADSWVTKCKL 443

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST
Match: SMESG000038402.1 (SMESG000038402.1)

HSP 1 Score: 86.2705 bits (212), Expect = 1.586e-21
Identity = 43/56 (76.79%), Postives = 52/56 (92.86%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y++  ++FLN+ASKFIGICKLVLLMLLLGHWNAC+QFLIP+LME+P ESWV+KC L
Sbjct:  362 YVSQWEEFLNIASKFIGICKLVLLMLLLGHWNACIQFLIPVLMEFPTESWVVKCKL 417

[Close]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST
Match: SMESG000020049.1 (SMESG000020049.1)

HSP 1 Score: 77.411 bits (189), Expect = 2.084e-18
Identity = 41/56 (73.21%), Postives = 49/56 (87.50%), Query Frame = 2

Query:   44 YLTFPQKFLNMASKFIGICKLVLLMLLLGHWNACLQFLIPMLMEYPAESWVIKCNL 211
            Y++  ++ LN+ASKFIGI  LVLLMLLLGHWNACLQFLIPML +YP++SWVIKC L
Sbjct:  440 YVSQWEELLNVASKFIGIFNLVLLMLLLGHWNACLQFLIPMLRDYPSDSWVIKCKL 495

The following BLAST results are available for this feature:

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Human
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Celegans
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Mouse
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Sea Lamprey
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Yeast
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Nematostella
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HCN2	1.087e-11	52.38	hyperpolarization activated cyclic nucleotide gate...	[more]
HCN4	1.531e-10	50.00	hyperpolarization activated cyclic nucleotide gate...	[more]
HCN3	1.880e-10	50.00	hyperpolarization activated cyclic nucleotide gate...	[more]
HCN3	1.880e-10	50.00	hyperpolarization activated cyclic nucleotide gate...	[more]
HCN1	5.914e-10	47.62	hyperpolarization activated cyclic nucleotide gate...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ih	6.402e-16	62.22	gene:FBgn0263397 transcript:FBtr0290110	[more]
Ih	6.403e-16	62.22	gene:FBgn0263397 transcript:FBtr0100372	[more]
Ih	2.961e-15	61.36	gene:FBgn0263397 transcript:FBtr0100369	[more]
Ih	2.961e-15	61.36	gene:FBgn0263397 transcript:FBtr0290109	[more]
Ih	5.884e-13	61.36	gene:FBgn0263397 transcript:FBtr0290292	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hcn4	3.537e-12	52.27	hyperpolarization activated cyclic nucleotide-gate...	[more]
hcn4	3.541e-12	52.27	hyperpolarization activated cyclic nucleotide-gate...	[more]
hcn4l	9.197e-12	50.00	hyperpolarization activated cyclic nucleotide-gate...	[more]
hcn4l	9.204e-12	50.00	hyperpolarization activated cyclic nucleotide-gate...	[more]
hcn3	2.880e-11	44.68	hyperpolarization activated cyclic nucleotide-gate...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000054879.1	1.019e-10	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
ENSXETT00000054881.1	1.019e-10	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
ENSXETT00000054883.1	1.019e-10	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
ENSXETT00000054880.1	1.020e-10	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
ENSXETT00000054882.1	1.022e-10	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hcn2	1.722e-12	52.38	hyperpolarization-activated, cyclic nucleotide-gat...	[more]
Hcn2	1.722e-12	52.38	hyperpolarization-activated, cyclic nucleotide-gat...	[more]
Hcn3	6.705e-11	50.00	hyperpolarization-activated, cyclic nucleotide-gat...	[more]
Hcn4	1.011e-10	50.00	hyperpolarization-activated, cyclic nucleotide-gat...	[more]
Hcn1	4.110e-10	47.62	hyperpolarization activated cyclic nucleotide gate...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9JKA9\|HCN2_RAT	1.204e-11	52.38	Potassium/sodium hyperpolarization-activated cycli...	[more]
sp\|O88703\|HCN2_MOUSE	1.204e-11	52.38	Potassium/sodium hyperpolarization-activated cycli...	[more]
sp\|Q9UL51\|HCN2_HUMAN	5.219e-11	52.38	Potassium/sodium hyperpolarization-activated cycli...	[more]
sp\|O88705\|HCN3_MOUSE	4.690e-10	50.00	Potassium/sodium hyperpolarization-activated cycli...	[more]
sp\|Q9JKA8\|HCN3_RAT	4.690e-10	50.00	Potassium/sodium hyperpolarization-activated cycli...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3Q0KQ67	1.602e-19	66.07	Putative potassium/sodium hyperpolarization-activa...	[more]
A0A504YD75	3.624e-19	64.29	Hyperpolarization activated cyclic nucleotide-gate...	[more]
A0A4E0R7H0	3.624e-19	64.29	Hyperpolarization activated cyclic nucleotide-gate...	[more]
A0A3R7FDZ8	5.192e-19	64.29	Potassium/sodium hyperpolarization-activated cycli...	[more]
A0A1S8WT36	7.172e-19	69.23	Uncharacterized protein (Fragment) OS=Opisthorchis...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000011919.2	3.275e-12	48.94	pep primary_assembly:Astyanax_mexicanus-2.0:10:254...	[more]
hcn4	4.241e-12	52.27	potassium/sodium hyperpolarization-activated cycli...	[more]
hcn4l	1.112e-11	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
hcn4l	1.113e-11	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
hcn3	1.943e-11	48.94	hyperpolarization activated cyclic nucleotide-gate...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000007865.1	2.283e-10	50.00	pep scaffold:Pmarinus_7.0:GL480431:10244:18565:-1 ...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO49064	1.325e-12	46.43	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34316	2.785e-10	42.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000019259.2	3.227e-12	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
hcn4	4.256e-12	52.27	hyperpolarization activated cyclic nucleotide-gate...	[more]
ENSORLT00000019258.2	2.716e-11	52.38	potassium/sodium hyperpolarization-activated cycli...	[more]
ENSORLT00000013376.2	2.829e-11	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]
ENSORLT00000045599.1	2.835e-11	50.00	potassium/sodium hyperpolarization-activated cycli...	[more]

BLAST of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000038954.1	3.353e-44	100.00	SMESG000038954.1	[more]
SMESG000038954.1	1.956e-25	89.29	SMESG000038954.1	[more]
SMESG000001696.1	8.427e-24	67.86	SMESG000001696.1	[more]
SMESG000038402.1	1.586e-21	76.79	SMESG000038402.1	[more]
SMESG000020049.1	2.084e-18	73.21	SMESG000020049.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence

transcript sequence

>SMED30027502 ID=SMED30027502|Name=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel|organism=Schmidtea mediterranea sexual|type=transcript|length=213bp
AATATGTTTGTAGAAGTATTTGATCTCAACATGTGACCAAGGATATTTAA
CTTTTCCACAAAAGTTCCTAAATATGGCGAGCAAATTCATTGGCATTTGC
AAACTTGTTCTATTGATGCTTCTTCTCGGACACTGGAATGCCTGTCTGCA
GTTTTTAATACCAATGCTAATGGAATATCCAGCAGAATCTTGGGTTATCA
AATGTAATTTAAA

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0005249	voltage-gated potassium channel activity
GO:0030552	cAMP binding
GO:0005216	ion channel activity

Vocabulary: **biological process**
Term	Definition
GO:0006813	potassium ion transport
GO:0071805	potassium ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0006810	transport
GO:0006811	ion transport
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000017	photoreceptor neuron
PLANA:0000420	parapharyngeal region

Vocabulary: **INTERPRO**
Term	Definition
IPR030169	K/Na_HCN1

Vocabulary: **cellular component**
Term	Definition
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PANTHER	PTHR45689	FAMILY NOT NAMED	coord: 2..41
None	No IPR available	TMHMM	TMhelix		coord: 7..29
IPR030169	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	PANTHER	PTHR45689:SF3	POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1	coord: 2..41

Main menu

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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