msh6
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30027419 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of msh6 vs. Ensembl Human
Match: MSH6 (mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329]) HSP 1 Score: 591.267 bits (1523), Expect = 0.000e+0 Identity = 333/793 (41.99%), Postives = 484/793 (61.03%), Query Frame = 3
Query: 1200 FGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFD---NIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDK-PFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
GK+ G+ D C F+ + P ++++ KGNLSK T+ + S L+ + +E QF + TL L+ +YF E ++ + LP L +E+D++G + ++ ELA+S LG ++YL KCLID+ L+S+A+F Y P D D + + F M++D+ TL NL++ N + G +GTLLER+D T FG+RLL QW+ PLC+ I +R AI++L+ + +S + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F II I E V +SK+L++++ + G FPD++ ++ + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYLEKQ+ I I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD+ LK+ M ++F FD++Y W + IA D LL L ++SRG D GPM RP I + P D PFL + R PC KT G +FI N I +G N +L+TGPNMGGKSTLMRQ L+ +++Q+GCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE+
Sbjct: 435 LGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVM-LPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGA----IFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEE-----VADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGD-GPMCRPVI--LLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIG-CEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1195 HSP 2 Score: 252.292 bits (643), Expect = 7.220e-68 Identity = 138/303 (45.54%), Postives = 190/303 (62.71%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
RK+ TP TK SI+ TK L +FS N S + ++S +D + + + H + E+LK+E RD RR+PDHPD+D +TL++PE F++ TPG+++WW+IK+ N + +I +KVGKFYELYHMDA+ VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ EG E+ L S KE EE+ G +T GV V+T+ GKF I QF+DD SRFRTL++ +
Sbjct: 182 RKSSRKETP---SATKQATSISSETKNTLRAFSAPQN-SESQAHVSGGGDDSSRPTV--WYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQ-NFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSV---------LEGDPS----ENYSKYLLSLKEK--EEDSSG---HTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHY 459
BLAST of msh6 vs. Ensembl Human
Match: MSH6 (mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329]) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 331/792 (41.79%), Postives = 484/792 (61.11%), Query Frame = 3
Query: 1194 SRFGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDK-PFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
+ GK+ G+ D C F+ + P ++++ KGNLSK T+ + S L+ + +E QF + TL L+ +YF E ++ + LP L +E+D++G + ++ ELA+S LG ++YL KCLID+ L+S+A+F Y P D D + + F M++D+ TL NL++ N + G +GTLLER+D T FG+RLL QW+ PLC+ I +R AI++L+ + +S + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F + KI V +SK+L++++ + G FPD++ ++ + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYLEKQ+ I I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD+ LK+ M ++F FD++Y W + IA D LL L ++SRG D GPM RP I + P D PFL + R PC KT G +FI N I +G N +L+TGPNMGGKSTLMRQ L+ +++Q+GCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE+
Sbjct: 261 TSLGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVM-LPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGA----IFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII--GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGD-GPMCRPVI--LLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGC-EEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1023 HSP 2 Score: 251.906 bits (642), Expect = 3.659e-68 Identity = 138/303 (45.54%), Postives = 190/303 (62.71%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
RK+ TP TK SI+ TK L +FS N S + ++S +D + + + H + E+LK+E RD RR+PDHPD+D +TL++PE F++ TPG+++WW+IK+ N + +I +KVGKFYELYHMDA+ VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ EG E+ L S KE EE+ G +T GV V+T+ GKF I QF+DD SRFRTL++ +
Sbjct: 10 RKSSRKETP---SATKQATSISSETKNTLRAFSAPQN-SESQAHVSGGGDDSSRPTV--WYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQ-NFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSV---------LEGDPS----ENYSKYLLSLKEK--EEDSSG---HTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHY 287
BLAST of msh6 vs. Ensembl Human
Match: MSH6 (mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329]) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 331/792 (41.79%), Postives = 484/792 (61.11%), Query Frame = 3
Query: 1194 SRFGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDK-PFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
+ GK+ G+ D C F+ + P ++++ KGNLSK T+ + S L+ + +E QF + TL L+ +YF E ++ + LP L +E+D++G + ++ ELA+S LG ++YL KCLID+ L+S+A+F Y P D D + + F M++D+ TL NL++ N + G +GTLLER+D T FG+RLL QW+ PLC+ I +R AI++L+ + +S + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F + KI V +SK+L++++ + G FPD++ ++ + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYLEKQ+ I I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD+ LK+ M ++F FD++Y W + IA D LL L ++SRG D GPM RP I + P D PFL + R PC KT G +FI N I +G N +L+TGPNMGGKSTLMRQ L+ +++Q+GCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE+
Sbjct: 261 TSLGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVM-LPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGA----IFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII--GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGD-GPMCRPVI--LLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGC-EEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1023 HSP 2 Score: 251.906 bits (642), Expect = 3.659e-68 Identity = 138/303 (45.54%), Postives = 190/303 (62.71%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
RK+ TP TK SI+ TK L +FS N S + ++S +D + + + H + E+LK+E RD RR+PDHPD+D +TL++PE F++ TPG+++WW+IK+ N + +I +KVGKFYELYHMDA+ VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ EG E+ L S KE EE+ G +T GV V+T+ GKF I QF+DD SRFRTL++ +
Sbjct: 10 RKSSRKETP---SATKQATSISSETKNTLRAFSAPQN-SESQAHVSGGGDDSSRPTV--WYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQ-NFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSV---------LEGDPS----ENYSKYLLSLKEK--EEDSSG---HTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHY 287
BLAST of msh6 vs. Ensembl Human
Match: MSH6 (mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329]) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 333/793 (41.99%), Postives = 484/793 (61.03%), Query Frame = 3
Query: 1200 FGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFD---NIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDK-PFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
GK+ G+ D C F+ + P ++++ KGNLSK T+ + S L+ + +E QF + TL L+ +YF E ++ + LP L +E+D++G + ++ ELA+S LG ++YL KCLID+ L+S+A+F Y P D D + + F M++D+ TL NL++ N + G +GTLLER+D T FG+RLL QW+ PLC+ I +R AI++L+ + +S + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F II I E V +SK+L++++ + G FPD++ ++ + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYLEKQ+ I I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD+ LK+ M ++F FD++Y W + IA D LL L ++SRG D GPM RP I + P D PFL + R PC KT G +FI N I +G N +L+TGPNMGGKSTLMRQ L+ +++Q+GCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE+
Sbjct: 466 LGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVM-LPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGA----IFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEE-----VADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGD-GPMCRPVI--LLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIG-CEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1226 HSP 2 Score: 251.906 bits (642), Expect = 9.846e-68 Identity = 138/303 (45.54%), Postives = 190/303 (62.71%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
RK+ TP TK SI+ TK L +FS N S + ++S +D + + + H + E+LK+E RD RR+PDHPD+D +TL++PE F++ TPG+++WW+IK+ N + +I +KVGKFYELYHMDA+ VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ EG E+ L S KE EE+ G +T GV V+T+ GKF I QF+DD SRFRTL++ +
Sbjct: 213 RKSSRKETP---SATKQATSISSETKNTLRAFSAPQN-SESQAHVSGGGDDSSRPTV--WYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQ-NFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSV---------LEGDPS----ENYSKYLLSLKEK--EEDSSG---HTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHY 490
BLAST of msh6 vs. Ensembl Human
Match: MSH6 (mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329]) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 333/793 (41.99%), Postives = 484/793 (61.03%), Query Frame = 3
Query: 1200 FGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFD---NIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD-KPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
GK+ G+ D C F+ + P ++++ KGNLSK T+ + S L+ + +E QF + TL L+ +YF E ++ + LP L +E+D++G + ++ ELA+S LG ++YL KCLID+ L+S+A+F Y P D D + + F M++D+ TL NL++ N + G +GTLLER+D T FG+RLL QW+ PLC+ I +R AI++L+ + +S + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F II I E V +SK+L++++ + G FPD++ ++ + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYLEKQ+ I I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD+ LK+ M ++F FD++Y W + IA D LL L ++SRG D GPM RP I + P D PFL + R PC KT G +FI N I +G N +L+TGPNMGGKSTLMRQ L+ +++Q+GCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE+
Sbjct: 565 LGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVM-LPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGA----IFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEE-----VADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGD-GPMCRPVI--LLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIG-CEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1325 HSP 2 Score: 252.292 bits (643), Expect = 1.199e-67 Identity = 139/312 (44.55%), Postives = 193/312 (61.86%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISK 1317
RK+ TP TK SI+ TK L +FS N S + ++S +D + + + H + E+LK+E RD RR+PDHPD+D +TL++PE F++ TPG+++WW+IK+ N + +I +KVGKFYELYHMDA+ VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ EG E+ L S KE EE+ G +T GV V+T+ GKF I QF+DD SRFRTL++ + ++ K
Sbjct: 312 RKSSRKETP---SATKQATSISSETKNTLRAFSAPQN-SESQAHVSGGGDDSSRPTV--WYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQ-NFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSV---------LEGDPS----ENYSKYLLSLKEK--EEDSSG---HTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEK 598
BLAST of msh6 vs. Ensembl Celegans
Match: msh-6 (MSH (MutS Homolog) family [Source:UniProtKB/TrEMBL;Acc:Q9N3T8]) HSP 1 Score: 429.483 bits (1103), Expect = 3.001e-176 Identity = 260/767 (33.90%), Postives = 433/767 (56.45%), Query Frame = 3
Query: 1299 EIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN--LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGP--MTRPEIRHINPGDKPFLIITEGRFPCKA------KTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLI 3569
+ I +G++S T+ + N L + E KQF+++ED + + + DY+ + P L L ++ L + S+ +++LA+S GA+ +YL LID ++S+ + +Y + + ++ Q KE + ++I+D L NL+++ N + +L ++ T FGRRLL W+ P CDP K+ +RQKAIK L+ DA+ ++ LK PDL++L+ KIH +GL HPDSRA+ ++ + +++KI + + + F K++ E+ ++ E +LL +++ + + E ++ E I FF+ FD+ A K+GKI+P +G D +YDE++ +KE +L +Y + K + +I F +GK ++ LE+PE+ +KV S++ S+RKGF RY T + E L+ L E ++ + + ++F +F W + + ++ FD L SL F++ P M PE N D P+LI+ +G PC A TQ+ FI+N+ +G+ + VMLLTGPNMGGKSTLMRQTA++ IL+ +G VPA + LTP+DR+FTR GAND I G+ST +E+ E ++L + HS LL+DELGRGT+T+DG A+A ++L++I+D + RT FSTH+H + + N++++HM C+++ +N + + ++++TFLY+L G CPKSYGF AA+LA I Q++ N ++ F +I
Sbjct: 440 QAIVERGSISSTTKSIINGILFSVPVEHLLPKKQFMTAEDVVRIVSNEDYYGSDASE------WPEVLKGMLEDSSILPKPST-DWQLALSAFGAIFWYLRDSLIDVDMLSMRNVTIY---NSNSMENDQ----KKEKIDWNGKNLILDGTALENLNIVPNGRDSHL-TSLYYVINKCSTPFGRRLLRSWLLQPTCDPKKLEQRQKAIKWLVSPDASSFMTTATATLKKIPDLDRLLQKIHTIGLKYRSEKHPDSRAIFFDTIKTNQKKIAELLAAIDGFKLCNKLRKEYIKVQKEGE-GCELLDELLGNEQ-----EMEEVDENIYFFEKMFDRSTAMKDGKIVPNAGCDEEYDEALNRVKEALNELNDYKDSVAKKYSCSIKFVDSGKVKYLLEMPEN--TKVSSSFELKSRRKGFIRYSTPDSEQLVAALDAVEKEKSKLGDDATRRVFEQFGHKNPIWLETVKLVSSFDVLTSLALFAKS---SPFEMCMPEF-DFNATD-PYLIVDKGVHPCLALQSRNEVTQTTSFIANSTTMGAS--------EAAVMLLTGPNMGGKSTLMRQTAVLAILAHIGSMVPAFS-MRLTPIDRIFTRIGANDRIMCGESTFFIELKETDIMLKNATKHSLLLVDELGRGTSTFDGTAIASAVLQKISDDLACRTFFSTHYHSICDSFTNHPNVRLAHMKCVVDKEN-----------NEDPTMEDVTFLYELESGICPKSYGFYAAKLAGIDHQVVRNAYLESNKFASNLII 1158 HSP 2 Score: 210.69 bits (535), Expect = 3.001e-176 Identity = 105/252 (41.67%), Postives = 154/252 (61.11%), Query Frame = 1
Query: 562 ESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISK 1317
E ++H S++FLK + IRD +R P+YDP TL++P F K TPG +QWW +K+ + +TI+ FKVGKFYE YHMDAV V L + +MRG+YAH+GFPE A SK ADQL+ G+KVAR+EQTET + + ER + +K KVV RE+C+V + GTR + + + G + ++ L + KE E K + GV +++T T I QF DDD RS+ RTL++ ++++ + +
Sbjct: 207 ERFDHESFDFLKPDKIRDGFKRPMSDPEYDPKTLWVPPDFHQKQTPGHRQWWTMKSQ-HFDTILLFKVGKFYETYHMDAVEVVRALNIAFMRGSYAHAGFPEHAASKFADQLMNHGYKVARIEQTETPQMLEERNQKTKTKEKVVRREVCRVTSNGTRTYGVLD------GVDLGSASSTLDPTAKHLLAIKEFHNPETGKS------SYGVCMIDTTTAHIRIGQFEDDDYRSQLRTLLANVIVVQAIVER 445
BLAST of msh6 vs. Ensembl Celegans
Match: msh-2 (MSH (MutS Homolog) family [Source:UniProtKB/TrEMBL;Acc:Q9TXR4]) HSP 1 Score: 146.747 bits (369), Expect = 1.611e-35 Identity = 161/644 (25.00%), Postives = 285/644 (44.25%), Query Frame = 3
Query: 1692 AIDDKEPFYTHQSH--MIIDSNTLTNLDLLK---NSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNN-LKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEII--SFFKTAFDQENAKKNGKI--IPESGIDADYDESVALIKEIERDLAEYLEKQ----------KKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKL--LEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQII------LNGLKK 3539
+I +K + + +H M+IDS + L+L + N + TL L+ T G +LL W++ PLC D I ER ++ L E ++++ L PD +L +R ++ + L + + F T + + +++ ++ + + R +L S+ ++I + + +++ FF +++EN + ++ +PE E ++++ER +AE L K+ K NS F+ F++ + E K + +I + + ++ E+ + + + K + ++S + K +E + IA D +SL++F+ G TRP ++ P L + + R P FI N + L + ++LTG NMGGKST +R AL I+L+Q+G +VP I + VD +FTR GA+D G ST EM + + IL + +SF++IDELGRGT+T+DG +A +I + I + +IF+THFH++ L E+ LQ+ ++NN I LYK+ G S+G A++ I E +I L GL+K
Sbjct: 255 SISEKYSIFNYGTHGNMLIDSCAVEALELFQLNYNYLEKSNNLTLYNVLNKCKTLPGEKLLRDWLSRPLCQIDHINERLDIVEALFENQTIRQKLRDSILARMPDCSQL------------------ARRLMRKCTL---QDLNRFYQAATLLETV---EMQLIQLSEAEQFAPSINR--LLKSEITEILKKVERFQVLCDEFFDFDYEKENKEIRVRVDFVPE------IQEISEKLEQMER-VAEKLRKKYSAKFECDNLKLDKNSQYGFY------FRVTLKEEKSIRKKDVHILETTKGSGVKFSVGELSDINDEFLEFHLKYTRAEEEVISMLCKKAEEFIPLIPAMAQLIATLDVFVSLSTFA-ATSSGIYTRP---NLLPLGSKRLELKQCRHPVIEGNSEKPFIPNDVVLDKCRL----------IILTGANMGGKSTYLRSAALSILLAQIGSFVPCSSATI-SVVDGIFTRVGASDKQSQGISTFMAEMLDCSAILQRATKNSFVVIDELGRGTSTFDGFGIASAIAQDILNRIQCLSIFATHFHEMGKLAEQPGAVALQMG------------------VQIENN----EIHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAAQLLEGLEK 822
BLAST of msh6 vs. Ensembl Celegans
Match: him-14 (MutS protein homolog him-14 [Source:UniProtKB/Swiss-Prot;Acc:Q23405]) HSP 1 Score: 105.531 bits (262), Expect = 9.875e-23 Identity = 84/328 (25.61%), Postives = 149/328 (45.43%), Query Frame = 3
Query: 2685 VINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPV-DRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKS-YGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDGKNISFES----IKMWQN-RFKK 3647
+++++ D L L ++S D P P I++GR P S + I+N L D ++TGPNM GKST ++QTA + I++Q+GC++PA + P+ +R+F+R G ND + +S EM++AA I+ Y +S +++DEL R T+T +G A+ ++I +++ T +THF + + + H + +N T +KL G YGF L+ IP+++I + ++L E R ++ ++S IK++ N RF++
Sbjct: 521 AMDALSSIDFLCGLATYSDLRDT----------CKPTFGPSFSISQGRHPILDWDDSEKTITNDTCLTR---------DRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASL--PIFNRIFSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKVL-KLQSYTFLATHFLDIAALANYSNAIDNYHFLPQTD--------------------ENSTKKHKLLRGQYRGPLYGFELVELSTIPDEVIEHA---------QSLATELRANVEDTERDYDSERRRIKVYMNHRFRE 797
BLAST of msh6 vs. Ensembl Celegans
Match: msh-5 (MutS protein homolog 5 [Source:UniProtKB/Swiss-Prot;Acc:Q19272]) HSP 1 Score: 91.6633 bits (226), Expect = 2.622e-18 Identity = 71/273 (26.01%), Postives = 118/273 (43.22%), Query Frame = 3
Query: 2796 DKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSI----LKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDGKN 3602
D+P + E P F+ N + G + ++ ++TGPN GKS M+ +++ LS +G +VPA I VDR+ TR DS+ G ST ++ + AL L + +S ++IDE G+GT T G +L S+ + R AD C P S+HFH L + N+ ++ + I +L+++T G S+ + A+ IP +I + K + TL+ E + + N
Sbjct: 598 DEPVIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKAS--------IITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGI-VDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRC-PHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGG-----------------KIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALKAGTLLKEIKAEVSNDN 843
BLAST of msh6 vs. Ensembl Celegans
Match: msh-5 (MutS protein homolog 5 [Source:UniProtKB/Swiss-Prot;Acc:Q19272]) HSP 1 Score: 91.2781 bits (225), Expect = 2.683e-18 Identity = 71/273 (26.01%), Postives = 118/273 (43.22%), Query Frame = 3
Query: 2796 DKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSI----LKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDGKN 3602
D+P + E P F+ N + G + ++ ++TGPN GKS M+ +++ LS +G +VPA I VDR+ TR DS+ G ST ++ + AL L + +S ++IDE G+GT T G +L S+ + R AD C P S+HFH L + N+ ++ + I +L+++T G S+ + A+ IP +I + K + TL+ E + + N
Sbjct: 152 DEPVIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKAS--------IITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGI-VDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRC-PHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGG-----------------KIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALKAGTLLKEIKAEVSNDN 397
BLAST of msh6 vs. Ensembl Fly
Match: Msh6 (gene:FBgn0036486 transcript:FBtr0075646) HSP 1 Score: 496.508 bits (1277), Expect = 7.940e-155 Identity = 292/760 (38.42%), Postives = 440/760 (57.89%), Query Frame = 3
Query: 1314 KGNLSKNTQHVFNSCLAATKKECFTNN-KQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYT---HQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVS--DHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFK---RYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMT--RPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIAD-SCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQ-NITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
K LS+ TQ + + L KE N K S+E TL +L++ Y+A ++ P L ++ D+LG + + Y+LA+ LG ++++ KC ++ ++ +A + LY P P QLA D +P +SHM++D+ TL+NL ++ G + +LL LD T FG+RLL W+ P CD I ERQ AI ELI + L ++ L PD E+ +A+IH+ G +K + DHPDSRA+L+E LY+++K+ F+ L F+++ K+ F ++ LL++I + G FPD+S+ + +F TAFD + A K G I P++G+DA+YD ++ I E+E+ L YL +Q++ I +FG+ K R+QL++PES SK +Y Q KG K RY T E LLK + +AED R++VLK++ ++F KF HY QW Q I+ +A D L SL ++ G M PE+ ++ D+PF+ + EG PC + +I N ++LG+ + P+ LLTGPNMGGKSTLMR+ L++I++Q+G ++PA L+ VDR+FTR GA D I +G ST VE+NE +LIL + + HS +L+DELGRGTATYDG A+A S++ +A+ C RT+FSTH+H L++ + + HMACM+E++ DN Q +TFLYK T G CPKSYGFNAA+LA +P+ II + +K E
Sbjct: 449 KSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTL-KLLAERYYAGPGSDD----NWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVP-------PDQLA--DAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFG-NKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMF------HQCKTTLLKRITQLPESG--GSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYA----GQQMVICVPEL--VSDADQPFIQLEEGYHPC---ANASTYIPNGLELGTA-------SEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPA-ASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKC--RTLFSTHYHNLIDFFHNDKRITLGHMACMVENE------------DNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVE 1148 HSP 2 Score: 218.394 bits (555), Expect = 2.188e-57 Identity = 162/484 (33.47%), Postives = 250/484 (51.65%), Query Frame = 1
Query: 55 SILSFFPKTPS-SKNKQTDILNIETANSKSK----VNKTDKIK-FKDNDSMPSTDNK--DSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRK------NVNASTPHKKKPTKDEKSIN--------------DSTKALLSSFSINANDSNIETNISQVIEDDFKNDIES----------YEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKH-ESSK-NKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISR-----FNLMKSFISKEIYQKILSMFLILVLLQP 1371
++L++F K+P+ K K T + + SKS+ N+ K+K K S P+ K SDD + ++ KR+ + + +S+ E + S + +YE +++ SG + +++ +P KK K K +N +ST L + N+++N Q D +DI + + H EFL+ + I+D + R+PDHPDYD +TL +PE F++ L+PG++QWW +K++ N + ++FFKVGKFYELYHMDA V+ELG TYMRG +AHSGFPEI+F KM+ LV +GFKVARVEQTET + MTER K +++K +KVV REICQ+ GT+ F + + + + L +E G + GV ++T+ G F + +F DD SR TL+S F KS +S+ Q+I+ L +L +P
Sbjct: 16 TLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRI--VQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQ---DASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSD-NYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKI--GPNHQPNYMLAIVEKDEGTCSRY-------------------GVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRT-QQIVRTVLGGILKEP 471
BLAST of msh6 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0344018) HSP 1 Score: 162.925 bits (411), Expect = 2.398e-40 Identity = 145/596 (24.33%), Postives = 266/596 (44.63%), Query Frame = 3
Query: 1806 TLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIK-NNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGK----------NRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEE 3560
++L LD T G RL+ QW+ PL + + +R ++ L+E + + + LK PD+ L K L + ++ D + Y+ +L + + I+K+ E +E I + K L D++ + + D E ++ E + A +D + ++++ +L +E+ + + +N G + + F++ + + + Y KG R+ + ++EG + + + + +I+ +I + T + N +AQ D L+S +R P RP++ + G + L++ + R PC + FI+N++ N + ++TGPNMGGKST +R ++++ +G +VP I + VD + R GA+D+I G ST VEM E + I+ + S ++IDELGRGT+TY+GC +A+SI + +A T+F+THFH++ + E ++ HMA + + + T LY++ G KS+G ARLAN PE ++ N + FE+E
Sbjct: 326 SVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKK-----LMRRKANLQDLFRI-YQVILRTPK--------------ILKVLHELDNSTIESVICAPF--KSFL----------KDLTGLKQMVEQVVDFEAIERG-----EYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPT-PYVRPKM--LEEGARE-LVLEDVRHPCLELQEHVNFIANSVDFKKEECN--------MFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATI-SMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADA-------------------DDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDE 852
BLAST of msh6 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0344019) HSP 1 Score: 162.925 bits (411), Expect = 2.398e-40 Identity = 145/596 (24.33%), Postives = 266/596 (44.63%), Query Frame = 3
Query: 1806 TLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIK-NNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGK----------NRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEE 3560
++L LD T G RL+ QW+ PL + + +R ++ L+E + + + LK PD+ L K L + ++ D + Y+ +L + + I+K+ E +E I + K L D++ + + D E ++ E + A +D + ++++ +L +E+ + + +N G + + F++ + + + Y KG R+ + ++EG + + + + +I+ +I + T + N +AQ D L+S +R P RP++ + G + L++ + R PC + FI+N++ N + ++TGPNMGGKST +R ++++ +G +VP I + VD + R GA+D+I G ST VEM E + I+ + S ++IDELGRGT+TY+GC +A+SI + +A T+F+THFH++ + E ++ HMA + + + T LY++ G KS+G ARLAN PE ++ N + FE+E
Sbjct: 326 SVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKK-----LMRRKANLQDLFRI-YQVILRTPK--------------ILKVLHELDNSTIESVICAPF--KSFL----------KDLTGLKQMVEQVVDFEAIERG-----EYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPT-PYVRPKM--LEEGARE-LVLEDVRHPCLELQEHVNFIANSVDFKKEECN--------MFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATI-SMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADA-------------------DDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDE 852
BLAST of msh6 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0080630) HSP 1 Score: 162.925 bits (411), Expect = 2.398e-40 Identity = 145/596 (24.33%), Postives = 266/596 (44.63%), Query Frame = 3
Query: 1806 TLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIK-NNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGK----------NRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEE 3560
++L LD T G RL+ QW+ PL + + +R ++ L+E + + + LK PD+ L K L + ++ D + Y+ +L + + I+K+ E +E I + K L D++ + + D E ++ E + A +D + ++++ +L +E+ + + +N G + + F++ + + + Y KG R+ + ++EG + + + + +I+ +I + T + N +AQ D L+S +R P RP++ + G + L++ + R PC + FI+N++ N + ++TGPNMGGKST +R ++++ +G +VP I + VD + R GA+D+I G ST VEM E + I+ + S ++IDELGRGT+TY+GC +A+SI + +A T+F+THFH++ + E ++ HMA + + + T LY++ G KS+G ARLAN PE ++ N + FE+E
Sbjct: 326 SVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKK-----LMRRKANLQDLFRI-YQVILRTPK--------------ILKVLHELDNSTIESVICAPF--KSFL----------KDLTGLKQMVEQVVDFEAIERG-----EYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPT-PYVRPKM--LEEGARE-LVLEDVRHPCLELQEHVNFIANSVDFKKEECN--------MFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATI-SMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADA-------------------DDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDE 852
BLAST of msh6 vs. Ensembl Fly
Match: spel1 (gene:FBgn0015546 transcript:FBtr0309281) HSP 1 Score: 162.925 bits (411), Expect = 2.398e-40 Identity = 145/596 (24.33%), Postives = 266/596 (44.63%), Query Frame = 3
Query: 1806 TLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIK-NNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGK----------NRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEE 3560
++L LD T G RL+ QW+ PL + + +R ++ L+E + + + LK PD+ L K L + ++ D + Y+ +L + + I+K+ E +E I + K L D++ + + D E ++ E + A +D + ++++ +L +E+ + + +N G + + F++ + + + Y KG R+ + ++EG + + + + +I+ +I + T + N +AQ D L+S +R P RP++ + G + L++ + R PC + FI+N++ N + ++TGPNMGGKST +R ++++ +G +VP I + VD + R GA+D+I G ST VEM E + I+ + S ++IDELGRGT+TY+GC +A+SI + +A T+F+THFH++ + E ++ HMA + + + T LY++ G KS+G ARLAN PE ++ N + FE+E
Sbjct: 326 SVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKK-----LMRRKANLQDLFRI-YQVILRTPK--------------ILKVLHELDNSTIESVICAPF--KSFL----------KDLTGLKQMVEQVVDFEAIERG-----EYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPT-PYVRPKM--LEEGARE-LVLEDVRHPCLELQEHVNFIANSVDFKKEECN--------MFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATI-SMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADA-------------------DDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDE 852
BLAST of msh6 vs. Ensembl Zebrafish
Match: msh6 (mutS homolog 6 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-020905-3]) HSP 1 Score: 623.239 bits (1606), Expect = 0.000e+0 Identity = 340/779 (43.65%), Postives = 482/779 (61.87%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRM--HVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD----KPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDN----PVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
P ++I+ KGN S T +F + +A++ +E QF ++ TL L DYF E+ + LP L +E D L + YELA+S LG ++YL KCL+D+ L S+ +F Y P D + Q + F M++D TL NL++L+NSS GG +GTLLERLD T FG+RLL QWI PLC+P I +R A+++L+ + S + + LK PDLE+L++KIH +G DHPDSRA+LYE ++YS+RKI DF+ L F K+ E + V ++++SKLLR+++L +++ G FPD+S + + TAFD + A+ G I P++G D +YD+++ IKE ERDL +YL++QKK + N++++GTG+NR+QLE+PES + +P Y S +KG+KRY T +IE + +L + EDKRD LK+ M ++F FD++Y W + +A D LLS+ +S+ DG M RPE+ PGD PFL + R PC KT G +FI N I +G D P +L+TGPNMGGKSTLMRQ L++IL+QLGCYVPAE + LTPVDR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++K +++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLANIPE +I +G KKA+ FE T+ + K L
Sbjct: 591 PAQVIFEKGNPSIETLKIFKAIVASSLQEGLNAGSQFWDAQKTLKVLAEEDYFKESKDDNKKASVLPPALKAMTSECDALSLTPKTGYELALSALGGCMFYLKKCLVDQELFSMGNFEEYVPVDVEMEQAGGASCF----FAKTNQRMVLDGVTLANLEILQNSSTGGPEGTLLERLDTCCTPFGKRLLKQWICAPLCNPSSIGDRLDALEDLMGAPSQTSEVTDLLKKLPDLERLLSKIHSMGTPLKGQDHPDSRAILYEEVVYSKRKIADFLAALEGF----KVMKEIVSIMEPVGEDLKSKLLRQVVLLKTENEDGLFPDLSPELKRWDTAFDHQKARTTGVITPKAGFDPEYDQALNGIKECERDLQDYLDRQKKRLGCKNLSYWGTGRNRYQLEVPESVSERSLPEEYEVRSTKKGWKRYSTKDIERMFSELQSWEDKRDAALKDCMRRLFYNFDKNYKDWQTAVECMAVLDVLLSMCRYSQSADGS-MARPEM--ALPGDGSYSAPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGDEEEAQDDTKALAPCVLVTGPNMGGKSTLMRQCGLVVILAQLGCYVPAES-LRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILLHATNHSLVLLDELGRGTATYDGTAIASAVVKELSEKICCRTLFSTHYHSLVEDHVQDPAVRLGHMACMVE---------NECE---DPSQETITFLYKFIRGACPKSYGFNAARLANIPEDVIQSGHKKARDFERSTVSLRIFKKL 1345 HSP 2 Score: 216.853 bits (551), Expect = 0.000e+0 Identity = 129/333 (38.74%), Postives = 190/333 (57.06%), Query Frame = 1
Query: 307 STNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINAN-DSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSK---NKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFN 1293
S K IK K E P +K++ E K A+ P S++ K+ LS+FS N DS N ++ ++H E+L+ +DAQR++ +YDPTTL++PE F+++ TPG+++WW++K+ +T++F+KVGKFYELYHMDAV V+EL LT+M+G +AHSGFPEI F + +D LV KG+KVARVEQTET + M R K + +KVV RE+C++IT GT+ +S+ + ET + L S KE EE+ G + GV ++T+ G+F I QF DD SR RTL++ ++
Sbjct: 297 SPVKPIKRKRPTEKPTKSKSKPE----TPKRAPAALP----------SVSTDAKSRLSAFSAPDNFDSQNSANGTE-------GGSTVWDHEKLEWLQDGKRKDAQRKRQSDENYDPTTLYVPEDFLNRTTPGMRRWWQLKSE-MFDTVLFYKVGKFYELYHMDAVIGVNELNLTFMKGTWAHSGFPEIGFGRFSDVLVQKGYKVARVEQTETPDMMEARCKKLARPTKFDKVVKREVCRIITRGTQTYSVLDGAPSETQSK-------------YLLSIKEK-SEEDSTG---HGHIYGVCFIDTSVGRFHIGQFQDDRHCSRLRTLVAHYS 590
BLAST of msh6 vs. Ensembl Zebrafish
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 232.261 bits (591), Expect = 6.515e-62 Identity = 192/706 (27.20%), Postives = 336/706 (47.59%), Query Frame = 3
Query: 1566 VSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGID-ADYDESVALIKEIERDLAEYLEKQKKII----NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQ--SGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPA-EGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL----DGKN-ISFESIKMWQNR 3638
+ CLG ++ YL + ++K L+ + F SD D HM++ + T+ NL++L N + G + G+LL LD + T FG+RLL +W++ PL I RQ+A+ E++ +++ L +I++ L PDLE+ + I Y +R+ +++L+ + ++L+ ++ + S LL+ ++L + P + F +++ AK K E +D D+ +EIE L + +E ++++ N ++++ +F +E+ S S VP+ ++ S K F RY T I ++L ++ + + F +HY+ + + +A D L SL ++ RPE+ +K ++IT G+ P +++ N L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA E V + VD ++ R GA+D+I G+ST E+ E + +L+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E E ++ HMA ++ + + + + ITFLY+L G +SYG N ARLA IPE I+ K+K E E L+ RK + D + I E++ W+ R
Sbjct: 459 ICCLGPVIQYLTEFKLEKILLCSSSFK-RLSSDPD--------------------HMLLSAATMKNLEILCNQTTGSVKGSLLWVLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLPSIQSLLTRLPDLERGLCSI------------------------YHKREFYLIISSLSRLN----VELQALMPAIQSQLSSPLLKTLLLDT--------PQLLSPAHNFLKVLNEKAAKTGNKT--EMFVDLTDFPVIRKTKEEIESVLLDIMEHRREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPADWVKISSTKVFGRYHTPFIVEKHRRLQQLREQLVIDCNHEWINFLQLFGDHYYILRKAVCHLATMDCLFSLAQVAKE---NNYCRPEVLE----EKSQILITAGKHPVITSLMGDQDQYVPNDTHLQG---DGKR-----AMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGI--VDGIYVRMGASDNISRGRSTFMEELLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVGCMTLFVTHYPPLCELEHLYPQHVGNYHMAFLLNEPESTSD-------EEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSK--ELEALVNSRRKMVRLLSDAWSIIDTETLLDWRKR 1079
BLAST of msh6 vs. Ensembl Zebrafish
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 231.876 bits (590), Expect = 9.226e-62 Identity = 192/706 (27.20%), Postives = 336/706 (47.59%), Query Frame = 3
Query: 1566 VSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGID-ADYDESVALIKEIERDLAEYLEKQKKII----NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQ--SGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPA-EGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL----DGKN-ISFESIKMWQNR 3638
+ CLG ++ YL + ++K L+ + F SD D HM++ + T+ NL++L N + G + G+LL LD + T FG+RLL +W++ PL I RQ+A+ E++ +++ L +I++ L PDLE+ + I Y +R+ +++L+ + ++L+ ++ + S LL+ ++L + P + F +++ AK K E +D D+ +EIE L + +E ++++ N ++++ +F +E+ S S VP+ ++ S K F RY T I ++L ++ + + F +HY+ + + +A D L SL ++ RPE+ +K ++IT G+ P +++ N L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA E V + VD ++ R GA+D+I G+ST E+ E + +L+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E E ++ HMA ++ + + + + ITFLY+L G +SYG N ARLA IPE I+ K+K E E L+ RK + D + I E++ W+ R
Sbjct: 459 ICCLGPVIQYLTEFKLEKILLCSSSFK-RLSSDPD--------------------HMLLSAATMKNLEILCNQTTGSVKGSLLWVLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLPSIQSLLTRLPDLERGLCSI------------------------YHKREFYLIISSLSRLN----VELQALMPAIQSQLSSPLLKTLLLDT--------PQLLSPAHNFLKVLNEKAAKTGNKT--EMFVDLTDFPVIRKTKEEIESVLLDIMEHRREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPADWVKISSTKVFGRYHTPFIVEKHRRLQQLREQLVIDCNHEWINFLQLFGDHYYILRKAVCHLATMDCLFSLAQVAKE---NNYCRPEVLE----EKSQILITAGKHPVITSLMGDQDQYVPNDTHLQG---DGKR-----AMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGI--VDGIYVRMGASDNISRGRSTFMEELLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVRCMTLFVTHYPPLCELEHLYPQHVGNYHMAFLLNEPESTSD-------EEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSK--ELEALVNSRRKMVRLLSDAWSIIDTETLLDWRKR 1079
BLAST of msh6 vs. Ensembl Zebrafish
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 230.335 bits (586), Expect = 2.678e-61 Identity = 191/706 (27.05%), Postives = 335/706 (47.45%), Query Frame = 3
Query: 1566 VSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGID-ADYDESVALIKEIERDLAEYLEKQKKII----NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQ--SGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPA-EGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL----DGKN-ISFESIKMWQNR 3638
+ CLG ++ YL + ++K L+ + F SD D HM++ + T+ NL++L N + G + G+LL LD + T FG+RLL +W++ PL I RQ+A+ E++ +++ L +I++ L PDLE+ + I+ + R +F +++ + ++L+ ++ + S LL+ ++L + P + F +++ AK K E +D D+ +EIE L + +E ++++ N ++++ +F +E+ S S VP+ ++ S K F RY T I ++L ++ + + F +HY+ + + +A D L SL ++ RPE+ +K ++IT G+ P +++ N L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA E V + VD ++ R GA+D+I G+ST E+ E + +L+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E E ++ HMA ++ + + + + ITFLY+L G +SYG N ARLA IPE I+ K+K E E L+ RK + D + I E++ W+ R
Sbjct: 459 ICCLGPVIQYLTEFKLEKILLCSSSFK-RLSSDPD--------------------HMLLSAATMKNLEILCNQTTGSVKGSLLWVLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLPSIQSLLTRLPDLERGLCSIY-----------------------HKRCSTQEFYLIISSLSRL-NVELQALMPAIQSQLSSPLLKTLLLDT--------PQLLSPAHNFLKVLNEKAAKTGNKT--EMFVDLTDFPVIRKTKEEIESVLLDIMEHRREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPADWVKISSTKVFGRYHTPFIVEKHRRLQQLREQLVIDCNHEWINFLQLFGDHYYILRKAVCHLATMDCLFSLAQVAKE---NNYCRPEVLE----EKSQILITAGKHPVITSLMGDQDQYVPNDTHLQG---DGKR-----AMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGI--VDGIYVRMGASDNISRGRSTFMEELLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVRCMTLFVTHYPPLCELEHLYPQHVGNYHMAFLLNEPESTSD-------EEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSK--ELEALVNSRRKMVRLLSDAWSIIDTETLLDWRKR 1083
BLAST of msh6 vs. Ensembl Zebrafish
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 229.565 bits (584), Expect = 4.723e-61 Identity = 183/673 (27.19%), Postives = 322/673 (47.85%), Query Frame = 3
Query: 1566 VSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGID-ADYDESVALIKEIERDLAEYLEKQKKII----NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQ--SGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPA-EGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
+ CLG ++ YL + ++K L+ + F SD D HM++ + T+ NL++L N + G + G+LL LD + T FG+RLL +W++ PL I RQ+A+ E++ +++ L +I++ L PDLE+ + I Y +R+ +++L+ + ++L+ ++ + S LL+ ++L + P + F +++ AK K E +D D+ +EIE L + +E ++++ N ++++ +F +E+ S S VP+ ++ S K F RY T I ++L ++ + + F +HY+ + + +A D L SL ++ + RPE+ +K ++IT G+ P +++ N L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA E V + VD ++ R GA+D+I G+ST E+ E + +L+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E E ++ HMA ++ + + + + ITFLY+L G +SYG N ARLA IPE I+ K+K E
Sbjct: 459 ICCLGPVIQYLTEFKLEKILLCSSSFK-RLSSDPD--------------------HMLLSAATMKNLEILCNQTTGSVKGSLLWVLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLPSIQSLLTRLPDLERGLCSI------------------------YHKREFYLIISSLSRLN----VELQALMPAIQSQLSSPLLKTLLLDT--------PQLLSPAHNFLKVLNEKAAKTGNKT--EMFVDLTDFPVIRKTKEEIESVLLDIMEHRREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPADWVKISSTKVFGRYHTPFIVEKHRRLQQLREQLVIDCNHEWINFLQLFGDHYYILRKAVCHLATMDCLFSLAQVAKENN---YCRPEVLE----EKSQILITAGKHPVITSLMGDQDQYVPNDTHLQG---DGKR-----AMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGI--VDGIYVRMGASDNISRGRSTFMEELLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVGCMTLFVTHYPPLCELEHLYPQHVGNYHMAFLLNEPESTSD-------EEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAAFKSKELE 1048
BLAST of msh6 vs. Ensembl Xenopus
Match: MSH6 (mutS homolog 6 [Source:NCBI gene;Acc:100145639]) HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0 Identity = 336/803 (41.84%), Postives = 489/803 (60.90%), Query Frame = 3
Query: 1203 GKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAE--TPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSH-MIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRM--HVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNP-VMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIME-FR 3581
GK+ G+ D C F+ + P +I++ KGN S +T+ V SCL+ + +E QF + TL L YF + P + LP L +E D+L + ++ ELA+S LGA +YYL KCLID+ L+S+A+F Y P D I+ Q + F+ S M++D TLTNL++L+N + G +GTLLE+LD T FG+RLL QW+ PLC+P I +R A+++L++L +S + LK PDLE+L++KIH +G +HPDSRAV+YE + YS++KI DF++ L F K+ E + N +S +L++I+ + G FPD+S + + T+FD E A+K G I P+ G D DYDE++ IK E+DL EYL+KQ+K ++ + ++GT KNR+Q+EIPES + +P Y S +KG+KRY T IE + L NAE++RD LK+ M ++F FD++Y +W + A D L+SL+ +S+G D GP+ RP I + PFL + R PC KT G +FI N I +G +S+ + D +L+TGPNMGGKSTL+RQ L ++++QLGCYVPAE LTPVDR+FTR GA+D I +G+ST VE++E + IL + + HS +L+DELGRGTAT+DG A+A +++K ++ S RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLA+IP++II G +KA+ FE T+ + FR
Sbjct: 492 GKFHVGQFEDDRHCS-----RFRTLVAHFPPIQILFEKGNPSSDTKKVLKSCLSTSIQESLQPTSQFWDAFKTLKTLAEEAYFEKDFQPGSG----NLPTVLKNLTSENDSLALTPGEKSELALSALGACIYYLKKCLIDQELLSMANFEEYIPVDTG-IEKAQAS----SSFFAKTSQRMVLDGVTLTNLEILQNGTNGSTEGTLLEKLDTCSTPFGKRLLKQWLCAPLCNPFSINDRLNAVEDLMDLPDKVSEVSELLKKLPDLERLLSKIHSIGSPLKSQNHPDSRAVMYEEIAYSKKKIADFLSALEGF----KVMREVISILEDAAANFKSSILKQIVSIKGKTPQGHFPDLSAELKRWDTSFDHEKARKTGVITPKVGFDPDYDEALKDIKTTEQDLNEYLDKQRKRLSCKTVVYWGTAKNRYQMEIPESVTERNLPEEYELKSTKKGYKRYWTKAIEKMFGDLANAEERRDAALKDCMRRLFYNFDKNYKEWQTAVECFAVLDVLISLSQYSQGGD-GPVCRPVIV-LQDNHLPFLELKGSRHPCITKTFFGDDFIPNDILIGCKEEDSDDSSDEAHCVLVTGPNMGGKSTLLRQAGLQVVMAQLGCYVPAES-CRLTPVDRVFTRLGASDRIMAGESTFFVELSETSSILQHATEHSLVLLDELGRGTATFDGTAIASAVVKELSQSVKCRTLFSTHYHSLVEDYSHSQAVRLGHMACMVE---------NEC---EDPSQETITFLYKFIKGACPKSYGFNAARLAHIPDEIIQVGHQKAREFESITVSLRLFR 1261 HSP 2 Score: 234.572 bits (597), Expect = 3.474e-62 Identity = 132/346 (38.15%), Postives = 202/346 (58.38%), Query Frame = 1
Query: 262 LSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
LSE D +E+S + K+ + P+ + P + ++E ++ N S K K LSSFS + + +TN + ++H +++L+ +D +R+K + DYDP+TL++P+ F++K TPG+++WW++K+ N +T+IF+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEIAF + +D LV KG+KVARVEQTET E M R K H S ++VV REIC++IT GT+ +S+ + E+ + L FKE + + + + ++ GV+ V+T+ GKF + QF DD SRFRTL++ F
Sbjct: 211 LSEPDSETEEDSPVKVPLKRKRGNPDKPTGPKKRLQDELSETPKRASNVSAEAKLK---------------LSSFSAPESFES-QTNAGGT------GSVSVWDHEKFDWLQDGRRKDLKRKKQNDADYDPSTLYVPDDFLNKCTPGMRKWWQLKSQ-NFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGAWAHSGFPEIAFGRFSDVLVQKGYKVARVEQTETPEMMEVRCKSMSHPSKFDRVVRREICRIITKGTQTYSVLDGNPSESHSK-------------YLLCFKEKMDDSSGQRRI-----YGVSFVDTSVGKFHVGQFEDDRHCSRFRTLVAHF 515
BLAST of msh6 vs. Ensembl Xenopus
Match: MSH6 (mutS homolog 6 [Source:NCBI gene;Acc:100145639]) HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0 Identity = 334/805 (41.49%), Postives = 489/805 (60.75%), Query Frame = 3
Query: 1203 GKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAE--TPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSH-MIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRM--HVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLG-SLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIME-FRKF 3587
GK+ G+ D C F+ + P +I++ KGN S +T+ V SCL+ + +E QF + TL L YF + P + LP L +E D+L + ++ ELA+S LGA +YYL KCLID+ L+S+A+F Y P D I+ Q + F+ S M++D TLTNL++L+N + G +GTLLE+LD T FG+RLL QW+ PLC+P I +R A+++L++L +S + LK PDLE+L++KIH +G +HPDSRAV+YE + YS++KI DF++ L F K+ E + N +S +L++I+ + G FPD+S + + T+FD E A+K G I P+ G D DYDE++ IK E+DL EYL+KQ+K ++ + ++GT KNR+Q+EIPES + +P Y S +KG+KRY T IE + L NAE++RD LK+ M ++F FD++Y +W + A D L+SL+ +S+G D GP+ RP I + PFL + R PC KT G +FI N I +G + + + + +L+TGPNMGGKSTL+RQ L ++++QLGCYVPAE LTPVDR+FTR GA+D I +G+ST VE++E + IL + + HS +L+DELGRGTAT+DG A+A +++K ++ S RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLA+IP++II G +KA+ FE T+ + FR+
Sbjct: 547 GKFHVGQFEDDRHCS-----RFRTLVAHFPPIQILFEKGNPSSDTKKVLKSCLSTSIQESLQPTSQFWDAFKTLKTLAEEAYFEKDFQPGSG----NLPTVLKNLTSENDSLALTPGEKSELALSALGACIYYLKKCLIDQELLSMANFEEYIPVDTG-IEKAQAS----SSFFAKTSQRMVLDGVTLTNLEILQNGTNGSTEGTLLEKLDTCSTPFGKRLLKQWLCAPLCNPFSINDRLNAVEDLMDLPDKVSEVSELLKKLPDLERLLSKIHSIGSPLKSQNHPDSRAVMYEEIAYSKKKIADFLSALEGF----KVMREVISILEDAAANFKSSILKQIVSIKGKTPQGHFPDLSAELKRWDTSFDHEKARKTGVITPKVGFDPDYDEALKDIKTTEQDLNEYLDKQRKRLSCKTVVYWGTAKNRYQMEIPESVTERNLPEEYELKSTKKGYKRYWTKAIEKMFGDLANAEERRDAALKDCMRRLFYNFDKNYKEWQTAVECFAVLDVLISLSQYSQGGD-GPVCRPVIV-LQDNHLPFLELKGSRHPCITKTFFGDDFIPNDILIGCKEEDSDDSSDEAHCVLVTGPNMGGKSTLLRQAGLQVVMAQLGCYVPAES-CRLTPVDRVFTRLGASDRIMAGESTFFVELSETSSILQHATEHSLVLLDELGRGTATFDGTAIASAVVKELSQSVKCRTLFSTHYHSLVEDYSHSQAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLAHIPDEIIQVGHQKAREFESITVSLRLFREL 1318 HSP 2 Score: 234.958 bits (598), Expect = 3.497e-62 Identity = 132/346 (38.15%), Postives = 202/346 (58.38%), Query Frame = 1
Query: 262 LSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
LSE D +E+S + K+ + P+ + P + ++E ++ N S K K LSSFS + + +TN + ++H +++L+ +D +R+K + DYDP+TL++P+ F++K TPG+++WW++K+ N +T+IF+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEIAF + +D LV KG+KVARVEQTET E M R K H S ++VV REIC++IT GT+ +S+ + E+ + L FKE + + + + ++ GV+ V+T+ GKF + QF DD SRFRTL++ F
Sbjct: 266 LSEPDSETEEDSPVKVPLKRKRGNPDKPTGPKKRLQDELSETPKRASNVSAEAKLK---------------LSSFSAPESFES-QTNAGGT------GSVSVWDHEKFDWLQDGRRKDLKRKKQNDADYDPSTLYVPDDFLNKCTPGMRKWWQLKSQ-NFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGAWAHSGFPEIAFGRFSDVLVQKGYKVARVEQTETPEMMEVRCKSMSHPSKFDRVVRREICRIITKGTQTYSVLDGNPSESHSK-------------YLLCFKEKMDDSSGQRRI-----YGVSFVDTSVGKFHVGQFEDDRHCSRFRTLVAHF 570
BLAST of msh6 vs. Ensembl Xenopus
Match: MSH6 (mutS homolog 6 [Source:NCBI gene;Acc:100145639]) HSP 1 Score: 586.26 bits (1510), Expect = 0.000e+0 Identity = 334/803 (41.59%), Postives = 488/803 (60.77%), Query Frame = 3
Query: 1203 GKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAE--TPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSH-MIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRM--HVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLG-SLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIME-FR 3581
GK+ G+ D C F+ + P +I++ KGN S +T+ V SCL+ + +E QF + TL L YF + P + LP L +E D+L + ++ ELA+S LGA +YYL KCLID+ L+S+A+F Y P D I+ Q + F+ S M++D TLTNL++L+N + G +GTLLE+LD T FG+RLL QW+ PLC+P I +R A+++L++L +S + LK PDLE+L++KIH +G +HPDSRAV+YE + YS++KI DF++ L F K+ E + N +S +L++I+ + G FPD+S + + T+FD E A+K G I P+ G D DYDE++ IK E+DL EYL+KQ+K ++ + ++GT KNR+Q+EIPES + +P Y S +KG+KRY T IE + L NAE++RD LK+ M ++F FD++Y +W + A D L+SL+ +S+G D GP+ RP I + PFL + R PC KT G +FI N I +G + + + + +L+TGPNMGGKSTL+RQ L ++++QLGCYVPAE LTPVDR+FTR GA+D I +G+ST VE++E + IL + + HS +L+DELGRGTAT+DG A+A +++K ++ S RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLA+IP++II G +KA+ FE T+ + FR
Sbjct: 495 GKFHVGQFEDDRHCS-----RFRTLVAHFPPIQILFEKGNPSSDTKKVLKSCLSTSIQESLQPTSQFWDAFKTLKTLAEEAYFEKDFQPGSG----NLPTVLKNLTSENDSLALTPGEKSELALSALGACIYYLKKCLIDQELLSMANFEEYIPVDTG-IEKAQAS----SSFFAKTSQRMVLDGVTLTNLEILQNGTNGSTEGTLLEKLDTCSTPFGKRLLKQWLCAPLCNPFSINDRLNAVEDLMDLPDKVSEVSELLKKLPDLERLLSKIHSIGSPLKSQNHPDSRAVMYEEIAYSKKKIADFLSALEGF----KVMREVISILEDAAANFKSSILKQIVSIKGKTPQGHFPDLSAELKRWDTSFDHEKARKTGVITPKVGFDPDYDEALKDIKTTEQDLNEYLDKQRKRLSCKTVVYWGTAKNRYQMEIPESVTERNLPEEYELKSTKKGYKRYWTKAIEKMFGDLANAEERRDAALKDCMRRLFYNFDKNYKEWQTAVECFAVLDVLISLSQYSQGGD-GPVCRPVIV-LQDNHLPFLELKGSRHPCITKTFFGDDFIPNDILIGCKEEDSDDSSDEAHCVLVTGPNMGGKSTLLRQAGLQVVMAQLGCYVPAES-CRLTPVDRVFTRLGASDRIMAGESTFFVELSETSSILQHATEHSLVLLDELGRGTATFDGTAIASAVVKELSQSVKCRTLFSTHYHSLVEDYSHSQAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLAHIPDEIIQVGHQKAREFESITVSLRLFR 1264 HSP 2 Score: 234.572 bits (597), Expect = 3.598e-62 Identity = 132/346 (38.15%), Postives = 202/346 (58.38%), Query Frame = 1
Query: 262 LSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
LSE D +E+S + K+ + P+ + P + ++E ++ N S K K LSSFS + + +TN + ++H +++L+ +D +R+K + DYDP+TL++P+ F++K TPG+++WW++K+ N +T+IF+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEIAF + +D LV KG+KVARVEQTET E M R K H S ++VV REIC++IT GT+ +S+ + E+ + L FKE + + + + ++ GV+ V+T+ GKF + QF DD SRFRTL++ F
Sbjct: 214 LSEPDSETEEDSPVKVPLKRKRGNPDKPTGPKKRLQDELSETPKRASNVSAEAKLK---------------LSSFSAPESFES-QTNAGGT------GSVSVWDHEKFDWLQDGRRKDLKRKKQNDADYDPSTLYVPDDFLNKCTPGMRKWWQLKSQ-NFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGAWAHSGFPEIAFGRFSDVLVQKGYKVARVEQTETPEMMEVRCKSMSHPSKFDRVVRREICRIITKGTQTYSVLDGNPSESHSK-------------YLLCFKEKMDDSSGQRRI-----YGVSFVDTSVGKFHVGQFEDDRHCSRFRTLVAHF 518
BLAST of msh6 vs. Ensembl Xenopus
Match: MSH3 (mutS homolog 3 [Source:NCBI gene;Acc:100486354]) HSP 1 Score: 228.409 bits (581), Expect = 4.165e-61 Identity = 184/614 (29.97%), Postives = 299/614 (48.70%), Query Frame = 3
Query: 1740 IDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANL-SNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVAL---IKEIERDLAEYLEKQKKII-NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
++ TL NL++L+N + G+L+ LD + T FGRR + QW+ PL + +I R +A+ E++ D+++ + ++++L PDLE+ V I+ H S ++ V+TL N +E ++ ++S LL+ I E P + E + F ++ A+ K + D+ + A I+E+ L +L +KI+ N ++ F +E+ S S VP +I S K R+ + I + L +K L KF E+Y + IN +A D + SL ++ G +II GR P + +F+ N+ SL+ + R VM++TGPNMGGKS+ ++Q ALI I++Q+G YVPAE V + VD +FTR GA D+I G+ST E+ + A IL +P S +++DELGRGT+T+DG A+A+S L+ I S + T+F TH+ L E EK + + HMA ++++ D D G + + Q++TFLY++T G +SYG N A+LA+IP ++ K+K EE
Sbjct: 351 MNGTTLKNLEILQNQTDLKTKGSLIWVLDHTRTCFGRRKIKQWVTQPLVNTREINARLEAVSEVLLSDSSVFTQVRSHLSKLPDLERGVCSIY----------HKKC----------STQEFFLIVSTLCNISN----NMEALIPAIKSQVKSPLLQTIF--------AEIPQMLEPMHKFLNVLNESAARTGNKTELFKDL-TDFPKISARKLEIQEMLLKLEAHLGDIRKILKNPAASYTSVYGQEFLIEVKNSLGSVVPPDWITVSSTKAVSRFHSPFIVENYRHLNQLREKLVLDCNTEWLHFLDKFGENYHSVCKSINHLATADCIFSLAEVAK---------------QDGYCSEIIIKNGRHPVIDLLLEEQSQFVPNST---SLMADKER-----VMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEA-VTVGIVDGIFTRMGAADNIYKGRSTFMDELLDTAEILKNATPRSLVILDELGRGTSTHDGIAIAYSTLEYIIKSVTSLTLFVTHYPSLCELEKAYAEQVGNYHMAFFVDEEEDTDSGFLQ-------QPQHVTFLYQITQGIAARSYGLNVAKLADIPHSVVTRAACKSKALEE 900
BLAST of msh6 vs. Ensembl Xenopus
Match: MSH3 (mutS homolog 3 [Source:NCBI gene;Acc:100486354]) HSP 1 Score: 224.557 bits (571), Expect = 2.300e-59 Identity = 206/708 (29.10%), Postives = 334/708 (47.18%), Query Frame = 3
Query: 1554 YELAVSC-LGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANL-SNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKI--------IPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE--ETLIMEFRKFLDGKNI-SFESIKMW 3629
++ +V C L A + YL + ++K L + ++F S +C++ ++ TL NL++L+N + G+L+ LD + T FGRR + QW+ PL + +I R +A+ E++ D+++ + ++++L PDLE+ V I+ + E L V+TL N +E ++ ++S LL+ I E P + E + F ++ A+ K P+ I A E ++ ++E L + + K S + +G L S V ST +S K R+ + I + L +K L KF E+Y + IN +A D + SL ++ DG RP + + G + +II GR P + +F+ N+ SL+ N R VM++TGPNMGGKS+ ++Q ALI I++Q+G YVPAE V + VD +FTR GA D+I G+ST E+ + A IL +P S +++DELGRGT+T+DG A+A+S L+ I S + T+F TH+ L E EK + + HMA ++++ D D G + Q++TFLY++T G +SYG N A+LA+IP ++ K+K EE E + + F NI S E +K W
Sbjct: 435 FDKSVICSLAATIKYLKEFHLEKILYNSSNFT-QMSSKNECLR--------------------MNGTTLKNLEILQNQTDLKTKGSLIWVLDHTRTCFGRRKIKQWVTQPLVNTREINARLEAVSEVLLSDSSVFTQVRSHLSKLPDLERGVCSIY------------HKKCSTQEFFL--------IVSTLCNISN----NMEALIPAIKSQVKSPLLQTIF--------AEIPQMLEPMHKFLNVLNESAARTGNKTELFKDLTDFPK--ISARKLEIQEMLLKLEAHLGDIRKILKNPAASYTSVYGQENENITL------ISCVLST--SSYSTKAVSRFHSPFIVENYRHLNQLREKLVLDCNTEWLHFLDKFGENYHSVCKSINHLATADCIFSLAEVAKQ-DG--YCRPAVH--DSGSE--IIIKNGRHPVIDLLLEEQSQFVPNST---SLMANKER-----VMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEA-VTVGIVDGIFTRMGAADNIYKGRSTFMDELLDTAEILKNATPRSLVILDELGRGTSTHDGIAIAYSTLEYIIKSVTSLTLFVTHYPSLCELEKAYAEQVGNYHMAFFVDEEEDTDSGAESLQ-----QPQHVTFLYQITQGIAARSYGLNVAKLADIPHSVVTRAACKSKALEELVEMKRKKLKAFQSAWNINSSEELKEW 1058
BLAST of msh6 vs. Ensembl Mouse
Match: Msh6 (mutS homolog 6 [Source:MGI Symbol;Acc:MGI:1343961]) HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0 Identity = 332/792 (41.92%), Postives = 481/792 (60.73%), Query Frame = 3
Query: 1200 FGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQ--LEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD--KPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
GK+ G+ D C F+ + P +I++ KGNLS T+ V L++ +E QF + TL L+ YF N S LP L +E+D++G + +E ELA+S LG +++YL KCLID+ L+S+A+F Y+P D D + + F M++D+ TL NL++ N + G +GTLLERLD T FG+RLL QW+ PLC P I +R A+++L+ + ++ + + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F + K+ LE V SK L++++ S G FPD++ + + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYL+KQ+ + +I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD LK+ M ++F FD+++ W + IA D LL L ++S+G D GPM RPEI + PG+ PFL R PC KT G +FI N I +G + + +L+TGPNMGGKSTL+RQ L+ +++QLGCYVPAE LTPVDR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE
Sbjct: 564 LGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGYFT---GNGDSSTVLPLVLKGMTSESDSVGLTPGEESELALSALGGIVFYLKKCLIDQELLSMANFEEYFPLDSDTVS----TVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAVPDKVTEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLE----EVAGGFTSKTLKQVVTLQSKSPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVLDVLLCLANYSQGGD-GPMCRPEI--VLPGEDTHPFLEFKGSRHPCITKTFFGDDFIPNDILIG-CEEEAEEHGKAYCVLVTGPNMGGKSTLIRQAGLLAVMAQLGCYVPAE-KCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSKSVCVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFE 1322 HSP 2 Score: 250.751 bits (639), Expect = 2.202e-67 Identity = 138/303 (45.54%), Postives = 189/303 (62.38%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
RK++ T K+ T I TK+ LS+FS N S +T++S D + + H + E+LK E RD RR+PDHP+++PTTL++PE F++ TPG+++WW++K+ N + +IF+KVGKFYELYHMDAV VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ + G Y L S KE EE G +T GV V+T+ GKF I QF+DD SRFRTL++ +
Sbjct: 312 RKSLKKETGSAKRAT----PILSETKSTLSAFSAPQN-SESQTHVSGGGNDSSGPTV--WYHETLEWLKPEKRRDEHRRRPDHPEFNPTTLYVPEEFLNSCTPGMRKWWQLKSQ-NFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLD---------GDPSENYSR----YLLSLKEK--EEETSG---HTRVYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHY 588
BLAST of msh6 vs. Ensembl Mouse
Match: Msh3 (mutS homolog 3 [Source:MGI Symbol;Acc:MGI:109519]) HSP 1 Score: 213.386 bits (542), Expect = 6.679e-56 Identity = 175/633 (27.65%), Postives = 299/633 (47.24%), Query Frame = 3
Query: 1734 MIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANL-SNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKI--------IPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLD 3593
M I+ TL NL++L+N + G+LL LD + T+FGRR L W+ PL +I R A+ +++ ++++ I+N L+ PD+E+ + I+ + + +F + + + K +L+ V ++QS LLR +++ E P++ + + + AK K P I +E +I I+ L E+ +KI+ ++ + F +EI S S +P+ ++ K R+ I ++L ++ L F EHY + ++ +A D + SL ++ G RP ++ ++ +II GR P + +F+ N+ SL +S R VM++TGPNMGGKS+ ++Q AL+ I++Q+G YVPAE I VD +FTR GA D+I G+ST E+ + A I+ SP S +++DELGRGT+T+DG A+A++ L+ T+F TH+ + E EK + + HM ++ +D D ++TFLY++T G +SYG N A+LA++P +++ K+K E E L+ RK L+
Sbjct: 493 MRINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIY-----------------------HKKCSTQEFFLIVKSLCQL-KSELQALMPAVNSHVQSDLLRALIV--------EAPELLSPVEHYLKVLNGPAAKVGDKTELFKDLSDFP--LIKKRKNEIQEVIHSIQMRLQEF----RKILKLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKVAKQ---GNYCRPTLQ-----EEKKIIIKNGRHPMIDVLLGEQDQFVPNST---SLSQDSER-----VMIITGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGI-VDGIFTRMGAADNIYKGRSTFMEELTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSG-----DMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSK--ELEGLVSLRRKRLE 1063
BLAST of msh6 vs. Ensembl Mouse
Match: Msh3 (mutS homolog 3 [Source:MGI Symbol;Acc:MGI:109519]) HSP 1 Score: 212.616 bits (540), Expect = 1.286e-55 Identity = 174/633 (27.49%), Postives = 298/633 (47.08%), Query Frame = 3
Query: 1734 MIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANL-SNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKI--------IPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLD 3593
M I+ TL NL++L+N + G+LL LD + T+FGRR L W+ PL +I R A+ +++ ++++ I+N L+ PD+E+ + I+ + + +F + + + K +L+ V ++QS LLR +++ E P++ + + + AK K P I +E +I I+ L E+ +KI+ ++ + F +EI S S +P+ ++ K R+ I ++L ++ L F EHY + ++ +A D + SL ++ G RP ++ ++ +II GR P + +F+ N+ L +S R VM++TGPNMGGKS+ ++Q AL+ I++Q+G YVPAE I VD +FTR GA D+I G+ST E+ + A I+ SP S +++DELGRGT+T+DG A+A++ L+ T+F TH+ + E EK + + HM ++ +D D ++TFLY++T G +SYG N A+LA++P +++ K+K E E L+ RK L+
Sbjct: 493 MRINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIY-----------------------HKKCSTQEFFLIVKSLCQL-KSELQALMPAVNSHVQSDLLRALIV--------EAPELLSPVEHYLKVLNGPAAKVGDKTELFKDLSDFP--LIKKRKNEIQEVIHSIQMRLQEF----RKILKLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKVAKQ---GNYCRPTLQ-----EEKKIIIKNGRHPMIDVLLGEQDQFVPNSTSLS----DSER-----VMIITGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGI-VDGIFTRMGAADNIYKGRSTFMEELTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSG-----DMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSK--ELEGLVSLRRKRLE 1062
BLAST of msh6 vs. Ensembl Mouse
Match: Msh2 (mutS homolog 2 [Source:MGI Symbol;Acc:MGI:101816]) HSP 1 Score: 162.54 bits (410), Expect = 4.429e-40 Identity = 159/595 (26.72%), Postives = 267/595 (44.87%), Query Frame = 3
Query: 1836 TAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANL--SNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDN-------------IIKIQLEFTRMHVEQNIQSKL-LRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPES-GIDADYDESVALIKEIERDLAEYLE---KQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSI-AQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
TA G+RL+ QWI PL D ++I ER ++ +E D+ L S ++ L+ PDL +L K + ++ D LY+G+ ++ + L ++ +I ++ +F++ ++ I++ L + ++ H K P++SE+ + D K +I + G+ D + + L + Y K++K++ +N NF + ++ S+ S + Y ++ KG E+ +D ++K I++ Y + Q +N + A DA++S S P RP I G +I+ R C FI N + ++ + ++TGPNMGGKST +RQT +I++++Q+GC+VP E + + VD + R GA DS G ST EM E A IL + S ++IDELGRGT+TYDG LA++I IA +F+THFH+L + +A I N H+ + +T LY++ G C +S+G + A LAN P +I +KA EE
Sbjct: 335 TAQGQRLVNQWIKQPLMDRNRIEERLNLVEAFVE-DSELRQSLQEDLLRRFPDLNRLAKKFQ-----RQAANLQDCYR-LYQGI----NQLPSVIQALEKYEGRHQALLLAVFVTPLIDLRSDFSKF--QEMIETTLDMDQVENHEFLVKPSFDPNLSEL----REVMDGLEKKMQSTLINAARGLGLDPGKQIKL--DSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEY---TKNKG-----------------EYEEAQDAIVKEIVN-----ISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPV-PYVRPVILEKGKGR---IILKASRHACVEVQDEVAFIPNDVHF-----EKDKQM---FHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEV-SIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAFCMFATHFHEL------------TALANQIPTVN-------NLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIACAKQKALELEE 853
BLAST of msh6 vs. Ensembl Mouse
Match: Msh4 (mutS homolog 4 [Source:MGI Symbol;Acc:MGI:1860077]) HSP 1 Score: 121.709 bits (304), Expect = 1.757e-27 Identity = 89/302 (29.47%), Postives = 147/302 (48.68%), Query Frame = 3
Query: 2631 IMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQN-ITFLYKLTHGGC-PKSYGFNAARLANIPEQIILNG 3530
I+ K+ ++ EH ++ ++++ D LLS F+ RPE L I +G P K + + ++N N+ + V+++TGPNM GKST ++Q AL I++Q+G YVPAE ++FTR +D I + ST EM E A IL + S +LIDELGRGT T +G +++++ + + S T+F+THF +L + N++ H H+ N + ++ I + YKL+ G K+YG AA +++P I+L+
Sbjct: 423 IVCKLLSEIYEHIHCLYKLSDTVSMLDMLLS---FAHACTLSDYVRPEFTDT-------LAIKQGWHPILEKISAEKPVAN---------NTYITEGSNVLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYASFRIAA-QIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGISYAVCEHLL-SIKAFTLFTTHFLELCHLDALYLNVENMHFEVQ--------------HVKNTSRNKDAILYTYKLSRGLTEEKNYGLKAAEASSLPSSIVLDA 689
BLAST of msh6 vs. UniProt/SwissProt
Match: sp|E1BYJ2|MSH6_CHICK (DNA mismatch repair protein Msh6 OS=Gallus gallus OX=9031 GN=MSH6 PE=3 SV=2) HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0 Identity = 331/801 (41.32%), Postives = 495/801 (61.80%), Query Frame = 3
Query: 1203 GKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFD--NIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
GK+ G+ D C F+ + P ++++ KGNL+ +TQ + L + +E + QF S+ TL L+ +YF E N S LP+ + +E+D+LG + + ELA+S LG +++YL KCLID+ L+S+A+F Y P D D + + F M++D TL NL++L+N + G +GTLLER+D T FG+RLL QW+ PLC+P I +R A+++L+ + A L+ I +LK PDLE+L++KIH +G +HPDSRA+ YE + YS++KI DF++ L F N I +E V + +S++L++++ G FPD+S + + TAFD A+K G I P++G D DYD+++ IK +E D YL+KQ+K++ ++ ++GTGKNR+Q+EIPE+ S+ +P Y S RKG+KRY T EIE +L +LINAE++RD LK+ M ++F FD++ W + IA D L+SL ++S+ D GP+ RP I PFL + R PC KT G +FI N I +GS + + + +L+TGPNMGGKSTLMRQ L++I++QLGCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E + IL + + HS +L+DELGRGTAT+DG A+A ++++ +A++ RT+FSTH+H L+E+ +++ HMACM+E++ + + ITFLYK G CPKSYGFNAARLA+IPE+II G +KAK FE++T+ + +FL
Sbjct: 543 GKFYVGQFSDDRHCS-----RFRTLVAHYTPVQVLFEKGNLTVDTQKILKGSLISCIQEGLISGSQFWSASKTLKVLLEEEYFKEN-QNTESGCVLPSVIKSLTSESDSLGLTPGENSELALSALGGIVFYLKKCLIDQELLSLANFEKYIPVDAD----NAKTVSSSNFFARTDRRMVLDGVTLMNLEVLQNGTNGTTEGTLLERIDSCCTPFGKRLLKQWLCAPLCNPTSINDRLDAVEDLLAVPAKLTEITEHLKKLPDLERLLSKIHSIGSPLKSQNHPDSRAIFYEEIKYSKKKIADFLSALEGFKVMNEIVDAME----EVASDFKSQVLKQLVTRKAKHPDGRFPDLSAELKRWDTAFDHNQARKTGVITPKAGFDPDYDKALQDIKTVEEDFRTYLDKQRKLLGLKSVLYWGTGKNRYQMEIPETATSRNLPEEYELKSTRKGYKRYWTKEIEKMLAELINAEERRDAALKDCMRRLFYNFDKNSQDWQTAVQCIAVLDVLMSLANYSQDGD-GPLCRPVILLPVDSAPPFLELKNARHPCITKTFFGDDFIPNDIVIGS--KDEDGGSEASCVLVTGPNMGGKSTLMRQAGLLVIMAQLGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETSSILQHATEHSLVLVDELGRGTATFDGTAIASAVVRELAENIKCRTLFSTHYHSLVEDYSGSAAVRLGHMACMVENE------------SEDPSQETITFLYKFIEGACPKSYGFNAARLADIPEEIIQKGHRKAKEFEKKTMSLRIFRFL 1313 HSP 2 Score: 236.498 bits (602), Expect = 5.217e-62 Identity = 134/333 (40.24%), Postives = 194/333 (58.26%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLS-----SFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISKEIY----QKILSMFLI 1353
RK N S P K+ ++E S A +S ++ A N E+ + N ++EH E+L++ +DA RR+ +HPDYDP TL++PE +++K TPG+++WW++K+ N + +I +KVGKFYELYHMDAVT V+ELGL +M+G++AHSGFPE AF + + LV KG+K+ARVEQTET E M R K H + +KVV REIC++IT GT+ +S+ + C T E+ L KE +E+ G+ GV V+T+ GKF + QF+DD SRFRTL++ + ++ K QKIL LI
Sbjct: 282 RKRGNVSKPSKRSSLENEHSEAPKRAAPVSLEAKSKLTLFAAPENFESQANAC--SGGTNGFAAWEHEKLEWLQEGKKKDAHRRRQNHPDYDPCTLYVPEDYLNKCTPGMRRWWQLKSQ-NFDAVICYKVGKFYELYHMDAVTGVNELGLIFMKGSWAHSGFPETAFGRFSAILVQKGYKIARVEQTETPEMMEARCKATAHTTKFDKVVRREICRIITKGTQTYSIID--CDPT-----------ENHNKYLLCVKE---KEDSSGQRV----YGVCFVDTSVGKFYVGQFSDDRHCSRFRTLVAHYTPVQVLFEKGNLTVDTQKILKGSLI 591
BLAST of msh6 vs. UniProt/SwissProt
Match: sp|P54276|MSH6_MOUSE (DNA mismatch repair protein Msh6 OS=Mus musculus OX=10090 GN=Msh6 PE=1 SV=3) HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0 Identity = 332/792 (41.92%), Postives = 481/792 (60.73%), Query Frame = 3
Query: 1200 FGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQ--LEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD--KPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
GK+ G+ D C F+ + P +I++ KGNLS T+ V L++ +E QF + TL L+ YF N S LP L +E+D++G + +E ELA+S LG +++YL KCLID+ L+S+A+F Y+P D D + + F M++D+ TL NL++ N + G +GTLLERLD T FG+RLL QW+ PLC P I +R A+++L+ + ++ + + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F + K+ LE V SK L++++ S G FPD++ + + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYL+KQ+ + +I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD LK+ M ++F FD+++ W + IA D LL L ++S+G D GPM RPEI + PG+ PFL R PC KT G +FI N I +G + + +L+TGPNMGGKSTL+RQ L+ +++QLGCYVPAE LTPVDR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE
Sbjct: 564 LGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGYFT---GNGDSSTVLPLVLKGMTSESDSVGLTPGEESELALSALGGIVFYLKKCLIDQELLSMANFEEYFPLDSDTVS----TVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAVPDKVTEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLE----EVAGGFTSKTLKQVVTLQSKSPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVLDVLLCLANYSQGGD-GPMCRPEI--VLPGEDTHPFLEFKGSRHPCITKTFFGDDFIPNDILIG-CEEEAEEHGKAYCVLVTGPNMGGKSTLIRQAGLLAVMAQLGCYVPAE-KCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSKSVCVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFE 1322 HSP 2 Score: 250.751 bits (639), Expect = 1.540e-66 Identity = 138/303 (45.54%), Postives = 189/303 (62.38%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
RK++ T K+ T I TK+ LS+FS N S +T++S D + + H + E+LK E RD RR+PDHP+++PTTL++PE F++ TPG+++WW++K+ N + +IF+KVGKFYELYHMDAV VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ + G Y L S KE EE G +T GV V+T+ GKF I QF+DD SRFRTL++ +
Sbjct: 312 RKSLKKETGSAKRAT----PILSETKSTLSAFSAPQN-SESQTHVSGGGNDSSGPTV--WYHETLEWLKPEKRRDEHRRRPDHPEFNPTTLYVPEEFLNSCTPGMRKWWQLKSQ-NFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLD---------GDPSENYSR----YLLSLKEK--EEETSG---HTRVYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHY 588
BLAST of msh6 vs. UniProt/SwissProt
Match: sp|P52701|MSH6_HUMAN (DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2) HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0 Identity = 333/793 (41.99%), Postives = 484/793 (61.03%), Query Frame = 3
Query: 1200 FGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFD---NIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD-KPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
GK+ G+ D C F+ + P ++++ KGNLSK T+ + S L+ + +E QF + TL L+ +YF E ++ + LP L +E+D++G + ++ ELA+S LG ++YL KCLID+ L+S+A+F Y P D D + + F M++D+ TL NL++ N + G +GTLLER+D T FG+RLL QW+ PLC+ I +R AI++L+ + +S + LK PDLE+L++KIH +G +HPDSRA++YE YS++KI DF++ L F II I E V +SK+L++++ + G FPD++ ++ + TAFD E A+K G I P++G D+DYD+++A I+E E+ L EYLEKQ+ I I ++G G+NR+QLEIPE+ ++ +P Y S +KG KRY T IE L LINAE++RD+ LK+ M ++F FD++Y W + IA D LL L ++SRG D GPM RP I + P D PFL + R PC KT G +FI N I +G N +L+TGPNMGGKSTLMRQ L+ +++Q+GCYVPAE LTP+DR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTAT+DG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I G +KA+ FE+
Sbjct: 565 LGKFFIGQFSDDRHCS-----RFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVM-LPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGA----IFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEE-----VADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGD-GPMCRPVI--LLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIG-CEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAE-VCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVE---------NECE---DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEK 1325 HSP 2 Score: 252.292 bits (643), Expect = 5.759e-67 Identity = 139/312 (44.55%), Postives = 193/312 (61.86%), Query Frame = 1
Query: 391 RKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISK 1317
RK+ TP TK SI+ TK L +FS N S + ++S +D + + + H + E+LK+E RD RR+PDHPD+D +TL++PE F++ TPG+++WW+IK+ N + +I +KVGKFYELYHMDA+ VSELGL +M+GN+AHSGFPEIAF + +D LV KG+KVARVEQTET E M R + H S ++VV REIC++IT GT+ +S+ EG E+ L S KE EE+ G +T GV V+T+ GKF I QF+DD SRFRTL++ + ++ K
Sbjct: 312 RKSSRKETP---SATKQATSISSETKNTLRAFSAPQN-SESQAHVSGGGDDSSRPTV--WYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQ-NFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSV---------LEGDPS----ENYSKYLLSLKEK--EEDSSG---HTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEK 598
BLAST of msh6 vs. UniProt/SwissProt
Match: sp|Q9VUM0|MSH6_DROME (Probable DNA mismatch repair protein Msh6 OS=Drosophila melanogaster OX=7227 GN=Msh6 PE=1 SV=2) HSP 1 Score: 496.508 bits (1277), Expect = 7.959e-154 Identity = 292/760 (38.42%), Postives = 440/760 (57.89%), Query Frame = 3
Query: 1314 KGNLSKNTQHVFNSCLAATKKECFTNN-KQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYT---HQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVS--DHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFK---RYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMT--RPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIAD-SCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQ-NITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
K LS+ TQ + + L KE N K S+E TL +L++ Y+A ++ P L ++ D+LG + + Y+LA+ LG ++++ KC ++ ++ +A + LY P P QLA D +P +SHM++D+ TL+NL ++ G + +LL LD T FG+RLL W+ P CD I ERQ AI ELI + L ++ L PD E+ +A+IH+ G +K + DHPDSRA+L+E LY+++K+ F+ L F+++ K+ F ++ LL++I + G FPD+S+ + +F TAFD + A K G I P++G+DA+YD ++ I E+E+ L YL +Q++ I +FG+ K R+QL++PES SK +Y Q KG K RY T E LLK + +AED R++VLK++ ++F KF HY QW Q I+ +A D L SL ++ G M PE+ ++ D+PF+ + EG PC + +I N ++LG+ + P+ LLTGPNMGGKSTLMR+ L++I++Q+G ++PA L+ VDR+FTR GA D I +G ST VE+NE +LIL + + HS +L+DELGRGTATYDG A+A S++ +A+ C RT+FSTH+H L++ + + HMACM+E++ DN Q +TFLYK T G CPKSYGFNAA+LA +P+ II + +K E
Sbjct: 449 KSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTL-KLLAERYYAGPGSDD----NWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVP-------PDQLA--DAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFG-NKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMF------HQCKTTLLKRITQLPESG--GSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYA----GQQMVICVPEL--VSDADQPFIQLEEGYHPC---ANASTYIPNGLELGTA-------SEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPA-ASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKC--RTLFSTHYHNLIDFFHNDKRITLGHMACMVENE------------DNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVE 1148 HSP 2 Score: 218.394 bits (555), Expect = 2.193e-56 Identity = 162/484 (33.47%), Postives = 250/484 (51.65%), Query Frame = 1
Query: 55 SILSFFPKTPS-SKNKQTDILNIETANSKSK----VNKTDKIK-FKDNDSMPSTDNK--DSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRK------NVNASTPHKKKPTKDEKSIN--------------DSTKALLSSFSINANDSNIETNISQVIEDDFKNDIES----------YEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKH-ESSK-NKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISR-----FNLMKSFISKEIYQKILSMFLILVLLQP 1371
++L++F K+P+ K K T + + SKS+ N+ K+K K S P+ K SDD + ++ KR+ + + +S+ E + S + +YE +++ SG + +++ +P KK K K +N +ST L + N+++N Q D +DI + + H EFL+ + I+D + R+PDHPDYD +TL +PE F++ L+PG++QWW +K++ N + ++FFKVGKFYELYHMDA V+ELG TYMRG +AHSGFPEI+F KM+ LV +GFKVARVEQTET + MTER K +++K +KVV REICQ+ GT+ F + + + + L +E G + GV ++T+ G F + +F DD SR TL+S F KS +S+ Q+I+ L +L +P
Sbjct: 16 TLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRI--VQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQ---DASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSD-NYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKI--GPNHQPNYMLAIVEKDEGTCSRY-------------------GVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRT-QQIVRTVLGGILKEP 471
BLAST of msh6 vs. UniProt/SwissProt
Match: sp|O74502|MSH6_SCHPO (DNA mismatch repair protein msh6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=msh6 PE=1 SV=1) HSP 1 Score: 332.028 bits (850), Expect = 3.020e-121 Identity = 231/763 (30.28%), Postives = 362/763 (47.44%), Query Frame = 3
Query: 1287 VQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNN-KQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVE--QNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEET 3563
V+P E+I K +S+ + C++++ F +F +E +++ DYF NGL A + +S E LA+S GAL +YL + +DK + S+ +F+ Y S + ++++ TL NL++ NS GG +GTL L +T FG+RL W+ PL I R ++ + + I L PDLE+L++++H R K DFV L F +I F ++ E + + LL +I I P++ E + + AF+ + A + G PE G +A+YD S E++ +L LE+ KK + S++NF GK +Q+E+P KVP + S K RY E+ +KKL+ AE+ ++ + K + +FD +Y QW +I A D SL+ + L G P RPEI G L E R PC + + F+ N + LG N +++LTGPNM GKSTL+RQ + +I++QLGC+VPA+ I TP+ ++TR GAND I S +ST VE++E IL P S +++DELGRGT+TYDG A+A+++L + + FSTH+ L + +++ MA +++ K++ +TFLYKL G CPKSYG N A +A +PE++I +KA E+ +
Sbjct: 552 VRPKELILEKSKISQKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVEREIIAGDYFK-------------NGLEG----APKILKSYLSEKPLAISAFGALFWYLRQLKLDKDMCSMGNFDEYDASQ-------------------QSTSLLMNGQTLKNLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARLDVVELIADNPVIRDTIWGFLHKLPDLERLISRVHA-----------------------GRSKPADFVRVLEGFQ---RINSAFDQLREEFMEVAEGTLLGEI--------IQSAPNMKEELEAWTRAFNWQKASEEGVFEPEIGFEAEYDTSQKYQSELKNELYALLEQYKKQLRCSSLNFKNIGKEVYQVEVPSD--VKVPVNWCKMSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMSRMQEKFYIRFDSNYEQWLALIKYTASIDCFFSLSQAAAAL-GEPYCRPEIIEQKDG---HLYFEELRHPCINASAASTFVPNDVVLGGESPN--------MIVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASI-TPMTSIYTRLGANDDIMSARSTFMVELSETKKILDECGPKSLVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYQSLCVDFMHHRQVRLMQMAAAVDE-----------------KIRRVTFLYKLEDGICPKSYGMNVASMAGLPEKVIDAAEEKASELEQAS 1212 HSP 2 Score: 128.257 bits (321), Expect = 3.020e-121 Identity = 111/365 (30.41%), Postives = 180/365 (49.32%), Query Frame = 1
Query: 250 RLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTE--NEFLSGIRKN-VNASTPHKKKPTKDE------KSINDSTKALLSSFSINANDSNIETNISQVI--EDDFKNDIESYE---HFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTA--VSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISR 1287
R K + DDESD + I + S P+ + E +E + G + V+ + P KK ++ E +S ++ S S++ + S ++N + V+ E+ + +E+++ + YE+L ++RDA + + P+YDP TL+IP S + P KQ+WKIK + M+T++FF+ GKFYELY DA V L LT R N G PE +F A Q + KG+++ARV+Q ET A+ + IK + KVV R + QV+T GT +E D + KESL +N + G+ ++T+TG F + +F DD R++ TL+++
Sbjct: 220 RHKRIVSDDESDD-----YVEPDHISEASSEASLPIDEVESMDEDVDGYSDHSVSVAAPIPKKESRKESSNSLYESYRLGSQIASPSPSVSGSASPTKSNKNGVLNREEKRRQRMEAFKKENNERYEWLL--DVRDADQNRVGDPNYDPRTLYIPPSAWATFKPFEKQFWKIKKD-LMDTVVFFQKGKFYELYENDAAIGHQVFSLKLT-DRVNMKMVGIPEASFDYWASQFIAKGYRIARVDQLET--ALGKEIKDRQRTQKEEKVVQRGLTQVLTSGTL----------------VDEAMLTSDLSTYCMAIKESLQSDN------EEPSFGICFIDTSTGGFHMCEFTDDIHRTKLDTLLTQ 551
BLAST of msh6 vs. TrEMBL
Match: F8U1P2 (Msh6 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=msh6 PE=2 SV=1) HSP 1 Score: 1542.71 bits (3993), Expect = 0.000e+0 Identity = 763/766 (99.61%), Postives = 763/766 (99.61%), Query Frame = 3
Query: 1290 QPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSN--INFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFR 3581
QPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAE PANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSN INFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEDDNDDDVGNNECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFR
Sbjct: 409 QPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAEAPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNVLINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEDDNDDDVGNNECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFR 1174 HSP 2 Score: 806.594 bits (2082), Expect = 0.000e+0 Identity = 402/420 (95.71%), Postives = 402/420 (95.71%), Query Frame = 1
Query: 46 MQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNKTDKIKFKDNDSMPSTDNKDSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFM-----SKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
MQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNKTDKIKFKDNDSMPSTDNKDSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFM SKLTPGLKQWWKIKANGNMETI FFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQL GFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVAL IAQFADDDQRSRFRTLISRF
Sbjct: 1 MQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNKTDKIKFKDNDSMPSTDNKDSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMMSLIQSKLTPGLKQWWKIKANGNMETIFFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQL---GFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVAL---------IAQFADDDQRSRFRTLISRF 408
BLAST of msh6 vs. TrEMBL
Match: A0A1S3Q6C7 (DNA mismatch repair protein OS=Salmo salar OX=8030 GN=msh6 PE=3 SV=1) HSP 1 Score: 631.328 bits (1627), Expect = 0.000e+0 Identity = 336/782 (42.97%), Postives = 491/782 (62.79%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAET------PANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD----KPFLIITEGRFPCKAKTQSGE-FISNTIKLGSLLMNSNRNLDN---PVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
P ++++ KGN S T+ +F + L++ +E T QF ++ TL L DYF E+ P + + LP+ L +++D+LG + + YELA+S LG ++YL KCL+D+ L+S+ +F Y P D + + A F + M++D TL NL++L+N S GG +GTLLERLD T FG+RLL QW+ +PLC+P I ER A+++L+ + A + + + LK PDLE+L++KIH +G K DHPDSRAVLYE + YS++KI DF++ L F + +I V + QS+LLR+++ D + G FPD+S + + TAFD + A+ G I P++G D ++D++++ IK ERDL +YL++QKK + N+ ++GTG+NRFQ+E+P+S + +P Y S +KG+KRY T EIE L +L + E+KRD LK+ M ++F FD++Y W + +A D LLSLT +S+G DGGPM RP++ + PGD FL + R PC KT G+ FI N I +G DN P +L+TGPNMGGKSTLMRQ L+++L+QLGCYVPAE + TPVDR+FTR GA+D I +G+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++ +A+ RT+FSTH+H L+E+ +++ HMACM+E++ D + + ITFLYK G CPKSYGFNAARLAN+PE +I +G +KAK FE T+ + K L
Sbjct: 607 PAQVLFEKGNPSAETRKIFKASLSSAMQEGLTAGSQFWDAQKTLKTLAEEDYFKESVGKDEEPGSSV----LPSVLKSMTSKSDSLGLTPKEGYELALSALGGCMFYLKKCLVDQELLSMTNFQEYVPVDVEM----EKAAGPTSFFSQTRQRMVLDGVTLANLEILQNVS-GGTEGTLLERLDTCSTPFGKRLLKQWLCSPLCNPTSIGERLDALEDLMGVQAQATEVSDLLKKLPDLERLLSKIHSIGTPKG-QDHPDSRAVLYEEVTYSKKKIADFLSALEGFKTMQEIVTILG--PVAGDFQSRLLRQVVNLKDDGQEGLFPDLSAELKRWDTAFDHQKARATGVITPKAGFDPEFDQALSGIKACERDLQDYLDRQKKRLGCRNLTYWGTGRNRFQMEVPDSVSERNIPEEYKVKSTKKGWKRYWTREIERLFSELQSFEEKRDAALKDCMRRLFYNFDKNYRDWQTGVECMAVLDVLLSLTRYSQGGDGGPMARPQV--LLPGDISQSAAFLDLRGSRHPCVTKTFFGDDFIPNDIAIGCPGSEEGGQEDNGHAPCVLVTGPNMGGKSTLMRQCGLVVVLAQLGCYVPAES-LSFTPVDRVFTRLGASDRIMAGESTFFVELSETASILHHGTKHSLVLLDELGRGTATYDGTAIASAVVNELAERICCRTLFSTHYHSLVEDYTNNPAVRLGHMACMVENEG-----------DEDPSQETITFLYKFITGACPKSYGFNAARLANLPEDVIQSGHRKAKEFERSTISLRVFKKL 1362 HSP 2 Score: 223.787 bits (569), Expect = 0.000e+0 Identity = 124/308 (40.26%), Postives = 186/308 (60.39%), Query Frame = 1
Query: 403 NASTPHKKKPTKDE--------KSINDSTKALLSSFSINANDS-NIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
+++ P K PT E +I +TK+ LS+FS A +S + + N S + ++H ++L++ +DA+RR+ DYDPTTL++PE F++K TPG+++WW++K+ + ++FFKVGKFYELYHMDAV V+ELGLT+M+G++AHSGFPEI F + +D LV +G+KVARVEQTET + M R K + ++VV RE+C++IT GT+ +S+ + ET + L S KE EE G+ + GV+ V+T+ G F + QF DD SR RTL+S +
Sbjct: 321 SSAKPKPKTPTLPETAKRAPLSSTITANTKSRLSAFS--APESFDSQANGSGACG---QGGATVWDHEKLDWLQEGRRKDAKRRRQSEEDYDPTTLYVPEDFLNKTTPGMRRWWQLKSE-TFDAVLFFKVGKFYELYHMDAVIGVNELGLTFMKGSWAHSGFPEIGFGRFSDGLVQRGYKVARVEQTETPDMMEARCKTMLKPTKFDRVVQREVCRIITRGTQTYSVLDGAPSETHSK-------------YLLSIKEK-AEEESSGRCR---TYGVSFVDTSVGYFHVGQFQDDRHCSRLRTLLSHY 605
BLAST of msh6 vs. TrEMBL
Match: A0A444UGZ1 (DNA mismatch repair protein OS=Acipenser ruthenus OX=7906 GN=EOD39_0145 PE=3 SV=1) HSP 1 Score: 630.172 bits (1624), Expect = 0.000e+0 Identity = 350/802 (43.64%), Postives = 497/802 (61.97%), Query Frame = 3
Query: 1203 GKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAET-PANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRM--HVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINS-NINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
GK+ G+ D C F+ + P ++++ KGNLS T+ + + LA+ +E + QF + TL L YF E+ N ++ LP L + +++D+LG + + YELA+S LGA ++YL KCL+D+ L+S+++F Y P D + + A F + M++D TL+NL++L+N S G +GTLLERLD T FG+RLL QW+ PLC+P I +R A ++L+ L LS + LK PDLE+L++KIH LG + DHPDSRA+LYE + YS+RKI DF++ L F KI LE T + +N +SKLL++I+ +S G FPD+S + ++TAFD + A+ G I P++G D ++D++++ I+ +R L EYLEKQ+K + S +I ++G GKNR+Q+EIPES + VP Y S RKG+KRY T EIE L +L+ +E+KRD LK+ M ++F FD +Y W + IA D L+ L ++S+G D GPM RPE+ G PFL + R PC KT G +FI N + +G S +L+TGPNMGGKSTLMRQ L++IL+QLGCYVPAE LTPVDR+FTR GA+D I +G+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++K +A++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLANIPE++I G KKAK FE T+ + K L
Sbjct: 626 GKFHVGQFQDDRHCS-----RFRTLVAHYAPAQLLFEKGNLSGETRKILKASLASVIQEGLQSESQFWDASKTLKVLAEEGYFKESNKKNGDAQDALPAVLKRMTSDSDSLGFTPGEGYELALSALGACVFYLKKCLVDQELLSMSNFEEYVPVDMEMGK----AKGSSSFFARTRQRMVLDGVTLSNLEILQNGSTGTAEGTLLERLDSCCTPFGKRLLKQWLCAPLCNPSSIDDRLHAAEDLMALPDKLSETRELLKKLPDLERLLSKIHSLGSTLKSQDHPDSRAILYEEVTYSKRKIADFLSALEGF----KIMLEVTSIIQPAVENFRSKLLKQIVSLRDESNEGLFPDLSAELKRWETAFDHQKARSTGVITPKAGFDPEFDQALSEIEGTQRSLQEYLEKQRKRLGSKSIVYWGIGKNRYQMEIPESVTERHVPKEYEVKSTRKGYKRYWTREIERLFGELVTSEEKRDGALKDCMRRLFYNFDNNYKDWQTAVECIAVLDVLICLANYSQGGD-GPMCRPEVVLPVDGAVPFLELRGSRHPCITKTFFGDDFIPNDVFIGCSGEESESQAS--CVLVTGPNMGGKSTLMRQCGLMVILAQLGCYVPAES-FRLTPVDRVFTRLGASDRIMAGESTFFVELSETASILHHGTSHSLVLLDELGRGTATYDGTAIASAVVKELAENIQCRTLFSTHYHSLVEDYSHCTAVRLGHMACMVE---------NEC---EDPSQETITFLYKFITGACPKSYGFNAARLANIPEEVIQTGHKKAKEFERITVSLRVFKEL 1398 HSP 2 Score: 195.667 bits (496), Expect = 1.003e-46 Identity = 105/244 (43.03%), Postives = 152/244 (62.30%), Query Frame = 1
Query: 568 YEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNK---VVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
++H ++L+ RD++RRK PDYDPTTL++ E F++K TPG+++WW++K+ + ++F+KVGKFYELYHMDAV V+E+ L +M+G++AHSGFPEI F + +D LV KG+KVARVEQ ET + M R K + K VV RE+C+VIT GT+ +S+ + E+ + L KE EE+ GV V+T+ GKF + QF DD SRFRTL++ +
Sbjct: 424 WDHEKLDWLQDGRRRDSKRRKQTDPDYDPTTLYVSEDFLNKCTPGMRRWWQLKSE-MFDAVLFYKVGKFYELYHMDAVIGVTEMALVFMKGSWAHSGFPEIGFGRYSDVLVQKGYKVARVEQLETPDMMEARCKTMACPTKFDRVVRREVCRVITKGTQTYSVLDGASSESHSK-------------YLLCVKEKADEESSGCHR----TYGVGFVDTSVGKFHVGQFQDDRHCSRFRTLVAHY 649
BLAST of msh6 vs. TrEMBL
Match: A0A060XRR2 (DNA mismatch repair protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00010330001 PE=3 SV=1) HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0 Identity = 336/779 (43.13%), Postives = 489/779 (62.77%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFG---LPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD----KPFLIITEGRFPCKAKTQSGE-FISNTIKLGSLLMNSNRNLDN---PVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
P ++++ KGN S T+ +F + L++ +E T QF ++ TL L DYF E+ K G LP+ L +E+D+LG + + YELA+S LG ++YL KCL+D+ L+S+ +F Y P D + + A F + M++D TL NL++L+N S GG +GTLLERLD T FG+RLL QW+ +PLC+P I ER A+++L+ + A + + + LK PDLE+L++KIH +G K DHPDSRAVLYE + YS++KI DF++ L F + +I + V + +S+LLR+++ D + G FPD+S + + TAFD + A+ G I P++G D ++D++++ IK ERDL +YL++QKK + N+ ++GTG+NRFQ+E+P+S + +P Y S +KG+KRY T EIE L +L + E+KRD LK+ M ++F FD++Y W + +A D LLSLT +S+G DGGPM RP++ + PGD FL + R PC KT G+ FI N I +G D P +L+TGPNMGGKSTLMRQ L+++L+QLGCYVPAE + TPVDR+FTR GA+D I +G+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++ +A RT+FSTH+H L+E+ +++ HMACM+E++ D + + ITFLYK G CPKSYGFNAARLAN+PE +I +G +KAK FE T+ + K L
Sbjct: 609 PAQVLFEKGNPSAETRKIFKASLSSAMQEGLTAGSQFWDAQKTLKTLAEEDYFKES-VRKDEESGSSVLPSVLKSMTSESDSLGLTPKEGYELALSALGGCMFYLKKCLVDQELLSMTNFQEYIPVDVE----MEKAAGPTSFFSQTRQRMVLDGVTLANLEILQNVS-GGTEGTLLERLDTCSTPFGKRLLKQWLCSPLCNPTSIGERLDALEDLMGVQAQATEVSDLLKKLPDLERLLSKIHSIGTPKG-QDHPDSRAVLYEEVTYSKKKIVDFLSALEGFKTMQEIVTILGPVAV--DFRSRLLRQVVNLKDDGQEGLFPDLSAELKRWDTAFDHQKARATGVITPKTGFDPEFDQALSGIKACERDLQDYLDRQKKRLGCRNLTYWGTGRNRFQMEVPDSVSERNIPEEYKVKSTKKGWKRYWTREIERLFSELQSLEEKRDAALKDCMRRLFYNFDKNYRDWQTGVECMAVLDVLLSLTRYSQGGDGGPMARPQV--LLPGDISQSAAFLDLRGSRHPCVTKTFFGDDFIPNDIAIGCPGGEEEGQEDKGHAPCVLVTGPNMGGKSTLMRQCGLVVVLAQLGCYVPAES-LSFTPVDRVFTRLGASDRIMAGESTFFVELSETASILHHGTKHSLVLLDELGRGTATYDGTAIASAVVNELAKRICCRTLFSTHYHSLVEDYTNNPAVRLGHMACMVENEG-----------DEDPSQETITFLYKFIAGACPKSYGFNAARLANLPEDVIQSGHRKAKEFERSTISLRVFKKL 1364 HSP 2 Score: 220.705 bits (561), Expect = 0.000e+0 Identity = 123/317 (38.80%), Postives = 184/317 (58.04%), Query Frame = 1
Query: 403 NASTPHKKKPTKDE--------KSINDSTKALLSSFSINAN-DSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISK 1317
+++ P K PT E +I TK+ LS+FS + DS + + + ++H ++L++ +DA+RR+ DYDPTTL++PE F++K TPG+++WW++K+ + ++FFKVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEI F + +D LV +G+KVARVEQTET + M R K + ++VV RE+C++IT GT+ +S+ + ET + L S KE EE G+ + GV+ V+T+ G F + QF DD SR RTL+S + + K
Sbjct: 323 SSAKPKPKTPTLPETAKRAPLSSTITADTKSRLSAFSAPESFDSQANGSGAGG-----QGGATVWDHEKLDWLQEGRRKDAKRRRQSEEDYDPTTLYVPEDFLNKTTPGMRRWWQLKSE-TFDAVLFFKVGKFYELYHMDAVIGVNELGLTFMKGAWAHSGFPEIGFGRFSDGLVQRGYKVARVEQTETPDMMEARCKTMLKPTKFDRVVQREVCRIITRGTQTYSVLDGAPSETHSK-------------YLLSIKEK-AEEESSGRCR---TYGVSFVDTSVGYFYVGQFQDDRHCSRLRTLLSHYTPAQVLFEK 616
BLAST of msh6 vs. TrEMBL
Match: A0A5A9P8P1 (DNA mismatch repair protein OS=Triplophysa tibetana OX=1572043 GN=E1301_Tti017289 PE=3 SV=1) HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0 Identity = 337/778 (43.32%), Postives = 486/778 (62.47%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGD----KPFLIITEGRFPCKAKTQSG-EFISNTIKLGSLLMNSNRNLDN-----PVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
P ++++ KGN S T +F + L++ +E QF ++ TL DYF ET +N + LP L +E+D+LG + K YELA+S LG ++YL KCL+D+ LVS+ +F Y P D + Q A F + M++D TL NL++L+NSS GG +GTLLERL+ T FG+RLL QW+ PLC+P I +R A+++L+ + + + + LK PDLE+L++KIH +G DHPD+RA+LYE L+YS+RKI DF+ L F + ++ V + +SKLLR+++L + K G FPD+ + + TAFD + A+ G I P+SG D +YD+++ IK+ E++L +L++QKK + ++++GTG+NR+QLE+P+S K +P Y S +KG+KRY T +IE L L + EDKRD LK+ M ++F FD++Y W + +A D LLS++ +S+ D GPM RPE+ + PGD PFL + R PC KT G +FI N I +G + DN P +L+TGPNMGGKSTLMRQ L++IL+QLGCYVPA+ + LTPVDR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++K +++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLANIPE++I +G KKA+ FE T+ + K L
Sbjct: 591 PAQVLFEKGNPSAETLKIFKATLSSALQEGLNAGSQFWDAQKTLKVFAEEDYFKETASNNVGGSVLPPTLKSMTSESDSLGLTPKKGYELALSALGGCIFYLKKCLVDQELVSMGNFEDYVPVDVEMEQ----AGGSSCFFAKTRQRMVLDGVTLANLEILQNSSNGGPEGTLLERLETCCTPFGKRLLKQWLCAPLCNPSSIADRLDALEDLMGAPSQSTEVTDLLKKLPDLERLLSKIHSMGTPLKGQDHPDTRAILYEELVYSKRKIADFLAALEGF--TVMKEVVSVMDPVAEGFRSKLLRQVVLLKTEHKDGLFPDLDPELKRWDTAFDHQKARTTGVITPKSGFDPEYDQALTGIKDCEKELQAFLDRQKKRLGCKTLSYWGTGRNRYQLEVPDSISEKSIPMEYEVRSTKKGWKRYSTKDIERLFSDLQSWEDKRDAALKDCMRRLFYNFDKNYKDWQTAVECMAVLDVLLSMSRYSQSGD-GPMVRPEM--VLPGDGCQPSPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGDSEEEGQDNMKANAPCVLVTGPNMGGKSTLMRQCGLVVILAQLGCYVPADS-LRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILLHATNHSLVLLDELGRGTATYDGTAIASAVVKELSEKICCRTLFSTHYHSLVEDHTQNPAVRLGHMACMVE---------NECE---DPSQETITFLYKFIGGACPKSYGFNAARLANIPEEVIQSGHKKAREFERSTVSLRLFKKL 1346 HSP 2 Score: 221.09 bits (562), Expect = 0.000e+0 Identity = 127/312 (40.71%), Postives = 187/312 (59.94%), Query Frame = 1
Query: 394 KNVNASTPHKKKPTKDE-KSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIK---HESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISK 1317
K+ + TP K P K S+ K+ LS+FS A D N E++ + ++ ++H E+L+ +DA+RR+ +YDP TL++PE FM+K TPG+++WW++K+ +T++F+KVGKFYELYHMDAV V+E+GLT+MRGN+AHSGFPEI F + +D LV KG+KVARVEQTET + M R K + ++VVNRE+C++IT GT+ +S+ + G + Y L S KE EE+ G+ GV V+T+ G F + QF DD SR RTL++ ++ + K
Sbjct: 313 KSSPSDTP-KPAPVKPATPSLGSDNKSRLSAFS--APD-NFESSGTGGLD----GGSTVWDHEKLEWLQDGKRKDARRRRQSDENYDPATLYVPEDFMNKTTPGMRRWWQLKSE-MFDTVLFYKVGKFYELYHMDAVIGVNEMGLTFMRGNWAHSGFPEIGFGRFSDVLVQKGYKVARVEQTETPDMMEARCKAITRPTKFDRVVNREVCRIITRGTQTYSVLD------GAPSGTQSKY-------LLSIKEK-SEEDSAGQGH---VYGVCFVDTSVGHFHVGQFQDDRHCSRLRTLVAHYSPAQVLFEK 598
BLAST of msh6 vs. Ensembl Cavefish
Match: msh6 (mutS homolog 6 [Source:NCBI gene;Acc:103027666]) HSP 1 Score: 620.542 bits (1599), Expect = 0.000e+0 Identity = 346/823 (42.04%), Postives = 505/823 (61.36%), Query Frame = 3
Query: 1164 GQIKKYCQHWSRFGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFG--LPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMH-VEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEI--RHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLG------SLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
G I C + G++ G+ +D C + + P ++++ K NLS T+ +F + +++ +E QF ++ TL L DYF E N+ G LP L +++D+LG + + YELA+S LG ++YL KCL+D+ L+S+A+F Y P D + Q A F + M++D TLTNL++L+NSS GG +GTLLERLD T FG+RLL QW+ PLC+P I +R AI++L+ A + LK PDLE+L++KIH +G +HPD RAVLYE L+YS+RKI DF++ L F + +I + M V + QSKLLR+++L + G FPD++ ++ + TAFD + A+ G I P+SG D ++D++V+ IK+ ER L +YL++QKK + ++++GTG+NR+Q+E+P+S + VP Y S +KG+KRY T EIE L +L + E+KRD LK+ M ++F FD++Y W + +A D LLSL+ +S+ D GPM RPE+ P PFL + R PC KT G +FI N I +G ++N+ L + V L+TGPNMGGKSTLMRQ L++IL+QLGCYVPA+ + LTPVDR+FTR GA+D I SG+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++K +++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK +G CPKSYGFNAARLA+IPE++I +G KA+ FE T+ + K L
Sbjct: 454 GHIYGVCFIDTSVGRFHVGQFHDDRHCS-----RLRTLVAHYAPAQVVFEKSNLSLETRKIFKAIVSSAMQEALNAGTQFWDAQKTLKTLAEEDYFKEI-ENEGGNAGSTLPTVLKAMTSDSDSLGLTPKEGYELALSALGGCMFYLKKCLVDQELLSMANFEEYVPVDVEMEQ----AEGASGFFARTRQRMVLDGVTLTNLEILQNSSTGGTEGTLLERLDTCCTPFGKRLLKQWLCAPLCNPTSIKDRLNAIEDLMGAPAQATEATELLKKLPDLERLLSKIHSMGTPLKGQNHPDCRAVLYEELVYSKRKIADFLSALEGFKAMQEI---VSLMESVSEGFQSKLLRQVVLLKTKCEDGLFPDLTPELNRWDTAFDHQKARTTGVITPKSGFDPEFDQAVSGIKDSERGLQDYLDRQKKRLGCRTLSYWGTGRNRYQMEVPDSVSERNVPEEYEVRSTKKGWKRYSTKEIERLFSELQSWEEKRDAALKDCMRRLFYNFDKNYRDWQTAVECMAVLDVLLSLSRYSQSAD-GPMARPEVVLPESGPQSSPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGTEEEEGEDTNKALASCV-LVTGPNMGGKSTLMRQCGLVVILAQLGCYVPADS-LCLTPVDRVFTRLGASDRIMSGESTFFVELSETASILLHGTNHSLVLLDELGRGTATYDGTAIASAVVKELSEKIHCRTLFSTHYHSLVEDYAQDPAVKLGHMACMVE---------NECE---DPSQETITFLYKFINGACPKSYGFNAARLASIPEEVIQSGHHKAREFERNTVALRIFKKL 1248 HSP 2 Score: 201.83 bits (512), Expect = 4.266e-52 Identity = 128/326 (39.26%), Postives = 190/326 (58.28%), Query Frame = 1
Query: 409 STPHKKKPTKDEKSIND---STKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNK---VVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENV-KGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMK--------SFISKEIYQKILS 1341
STP + P + S+N TKA LS+FS N + T S +E ++H ++L+ +DA+RR+ DYDPTTL++PE F +++TPG+++WW++K+ + ++F+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEI FS+ +D LV KG+KVARVEQTET E M R K + K VV RE+C+VIT GT+ +S+ + E + L + KE EE+ G + GV ++T+ G+F + QF DD SR RTL++ + + S +++I++ I+S
Sbjct: 215 STP-SETPKRAPASLNSVAVDTKARLSAFSAPENFESQGTAGSGGVEGH-----GVWDHEKLDWLQDGKRKDARRRRQSDEDYDPTTLYVPEEFSNRVTPGMRRWWQLKSE-MFDAVLFYKVGKFYELYHMDAVIGVNELGLTFMKGTWAHSGFPEIGFSRFSDVLVQKGYKVARVEQTETPEMMEARCKTMARPTKFDRVVRREVCRVITRGTQTYSVLDGAPSEVQSK-------------YLLAVKEKNEEESAGHGHI-----YGVCFIDTSVGRFHVGQFHDDRHCSRLRTLVAHYAPAQVVFEKSNLSLETRKIFKAIVS 515
BLAST of msh6 vs. Ensembl Cavefish
Match: msh6 (mutS homolog 6 [Source:NCBI gene;Acc:103027666]) HSP 1 Score: 577.785 bits (1488), Expect = 0.000e+0 Identity = 331/823 (40.22%), Postives = 483/823 (58.69%), Query Frame = 3
Query: 1164 GQIKKYCQHWSRFGKY*YGEIYDCTICR**SKVTFQDIDFSVQPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFG--LPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMH-VEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEI--RHINPGDKPFLIITEGRFPCKAKTQSG-EFISNTIKLG------SLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
G I C + G++ G+ +D C + + P ++++ K NLS T+ +F + +++ +E QF ++ TL L DYF E N+ G LP L +++D+LG + + YELA+S LG ++YL KCL+D+ L+S+A+F Y P D + Q A F + M++D TLTNL++L+NSS GG +GTLLERLD T FG+RLL QW+ PLC+P I +R AI++L+ A + LK PDLE+L++KIH +G +HPD RAVLYE L+YS+RKI DF++ L F + +I + M V + QSKLLR+++L + G FPD++ ++ + TAFD + A+ G I P+SG D ++D++V+ IK+ ER L +YL++QKK + ++++GTG+NR+Q+E+P+S + VP Y S +KG+KRY T EIE L +L + E+KRD LK+ M ++F FD++Y W + +A D LLSL+ +S+ D GPM RPE+ P PFL + R PC KT G +FI N I +G ++N+ L + V L+TGPNMGGKSTLMRQ L++IL+QLGCYVPA+ + LTPVDR+FTR GA+D I S GRGTATYDG A+A +++K +++ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK +G CPKSYGFNAARLA+IPE++I +G KA+ FE T+ + K L
Sbjct: 556 GHIYGVCFIDTSVGRFHVGQFHDDRHCS-----RLRTLVAHYAPAQVVFEKSNLSLETRKIFKAIVSSAMQEALNAGTQFWDAQKTLKTLAEEDYFKEI-ENEGGNAGSTLPTVLKAMTSDSDSLGLTPKEGYELALSALGGCMFYLKKCLVDQELLSMANFEEYVPVDVEMEQ----AEGASGFFARTRQRMVLDGVTLTNLEILQNSSTGGTEGTLLERLDTCCTPFGKRLLKQWLCAPLCNPTSIKDRLNAIEDLMGAPAQATEATELLKKLPDLERLLSKIHSMGTPLKGQNHPDCRAVLYEELVYSKRKIADFLSALEGFKAMQEI---VSLMESVSEGFQSKLLRQVVLLKTKCEDGLFPDLTPELNRWDTAFDHQKARTTGVITPKSGFDPEFDQAVSGIKDSERGLQDYLDRQKKRLGCRTLSYWGTGRNRYQMEVPDSVSERNVPEEYEVRSTKKGWKRYSTKEIERLFSELQSWEEKRDAALKDCMRRLFYNFDKNYRDWQTAVECMAVLDVLLSLSRYSQSAD-GPMARPEVVLPESGPQSSPFLDLRGSRHPCVTKTFFGDDFIPNDIFIGCPGTEEEEGEDTNKALASCV-LVTGPNMGGKSTLMRQCGLVVILAQLGCYVPADS-LCLTPVDRVFTRLGASDRIMS------------------------------GRGTATYDGTAIASAVVKELSEKIHCRTLFSTHYHSLVEDYAQDPAVKLGHMACMVE---------NECE---DPSQETITFLYKFINGACPKSYGFNAARLASIPEEVIQSGHHKAREFERNTVALRIFKKL 1320 HSP 2 Score: 201.83 bits (512), Expect = 4.015e-52 Identity = 128/326 (39.26%), Postives = 190/326 (58.28%), Query Frame = 1
Query: 409 STPHKKKPTKDEKSIND---STKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNK---VVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENV-KGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMK--------SFISKEIYQKILS 1341
STP + P + S+N TKA LS+FS N + T S +E ++H ++L+ +DA+RR+ DYDPTTL++PE F +++TPG+++WW++K+ + ++F+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEI FS+ +D LV KG+KVARVEQTET E M R K + K VV RE+C+VIT GT+ +S+ + E + L + KE EE+ G + GV ++T+ G+F + QF DD SR RTL++ + + S +++I++ I+S
Sbjct: 317 STP-SETPKRAPASLNSVAVDTKARLSAFSAPENFESQGTAGSGGVEGH-----GVWDHEKLDWLQDGKRKDARRRRQSDEDYDPTTLYVPEEFSNRVTPGMRRWWQLKSE-MFDAVLFYKVGKFYELYHMDAVIGVNELGLTFMKGTWAHSGFPEIGFSRFSDVLVQKGYKVARVEQTETPEMMEARCKTMARPTKFDRVVRREVCRVITRGTQTYSVLDGAPSEVQSK-------------YLLAVKEKNEEESAGHGHI-----YGVCFIDTSVGRFHVGQFHDDRHCSRLRTLVAHYAPAQVVFEKSNLSLETRKIFKAIVS 617
BLAST of msh6 vs. Ensembl Cavefish
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:103037699]) HSP 1 Score: 231.491 bits (589), Expect = 9.722e-62 Identity = 197/693 (28.43%), Postives = 331/693 (47.76%), Query Frame = 3
Query: 1563 AVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDI-SEIISFFKTAFDQENAKKNGKIIPESGIDADY---DESVALIKEIERDLAEYLEKQKKII-NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKI--FAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEI----RHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDG 3596
+ CLG ++ YL + +++ L+ + F SD D HM++ + T+ NL++ N + G + G+LL LD + T FG+RLL +W++ PL +I+ RQ+A+ E++ +++ L +I+ L PDLE+ + I Y ++ T L++ + ++ +EF Q + + +I S + + P + S +F K ENA K G D+ ++ I+ I D+ E+ + + I+ N ++N+ F +E+ S S VP ++ + K RY + I + L+ ++ LV+ + I F EHY+ + + +A D SL ++ + RPE+ RHI +I +GR P + +++ N +L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA I VD +FTR GA+D+I G+ST E+ EA+ ILS+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E EK ++ HMA ++ + + ++ + ITFLY+LT G +SYG N ARLANIPE I+ K+K E E +I R+ + G
Sbjct: 483 VICCLGPVIQYLTEFKLERVLLCPSSFRRLL-SDSD--------------------HMVLSATTMKNLEIFCNQTTGSVKGSLLWVLDHTHTPFGKRLLKKWVSQPLKSASEILSRQEAVAEILSSESSVLPSIQALLNRLPDLERGLCSI------------------------YHKKCSTQEFYLLSS--TLSRLGIEF------QALIPAVQSQISSALLKSLLLDTPQLLSPAHNFLKVL--NENAAKTGNKTELFADLTDFPVIEQRKDQIQNILSDIMEHRRELRLILRNPSLNYATVSGQEFLIEVKNSMSSVVPPDWVKINSTKVVGRYHSPFIVEKYRCLLQLREQ--LVIDSGQEWINFLQLFGEHYYILKKAVGHLATMDCFFSLAQVAKENN---YCRPEVLEQERHI--------VIRDGRHPVIDMLMGEQDQYVPNDTELQG---DGKR-----AMIVTGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASIGM-VDGIFTRMGASDNISRGRSTFMEELLEASEILSHATSRSLVILDELGRGTSTHDGIAIAYATLEFFIRDVKCLTLFVTHYPPLCELEKLYPLHVGNYHMAFLLNEPEIVGD-------EEEVQPEFITFLYQLTEGAAGRSYGLNVARLANIPESILRTAALKSK--ELEAIINSRRRAVKG 1089
BLAST of msh6 vs. Ensembl Cavefish
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:103037699]) HSP 1 Score: 231.491 bits (589), Expect = 9.722e-62 Identity = 197/693 (28.43%), Postives = 331/693 (47.76%), Query Frame = 3
Query: 1563 AVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDI-SEIISFFKTAFDQENAKKNGKIIPESGIDADY---DESVALIKEIERDLAEYLEKQKKII-NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKI--FAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEI----RHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDG 3596
+ CLG ++ YL + +++ L+ + F SD D HM++ + T+ NL++ N + G + G+LL LD + T FG+RLL +W++ PL +I+ RQ+A+ E++ +++ L +I+ L PDLE+ + I Y ++ T L++ + ++ +EF Q + + +I S + + P + S +F K ENA K G D+ ++ I+ I D+ E+ + + I+ N ++N+ F +E+ S S VP ++ + K RY + I + L+ ++ LV+ + I F EHY+ + + +A D SL ++ + RPE+ RHI +I +GR P + +++ N +L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA I VD +FTR GA+D+I G+ST E+ EA+ ILS+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E EK ++ HMA ++ + + ++ + ITFLY+LT G +SYG N ARLANIPE I+ K+K E E +I R+ + G
Sbjct: 483 VICCLGPVIQYLTEFKLERVLLCPSSFRRLL-SDSD--------------------HMVLSATTMKNLEIFCNQTTGSVKGSLLWVLDHTHTPFGKRLLKKWVSQPLKSASEILSRQEAVAEILSSESSVLPSIQALLNRLPDLERGLCSI------------------------YHKKCSTQEFYLLSS--TLSRLGIEF------QALIPAVQSQISSALLKSLLLDTPQLLSPAHNFLKVL--NENAAKTGNKTELFADLTDFPVIEQRKDQIQNILSDIMEHRRELRLILRNPSLNYATVSGQEFLIEVKNSMSSVVPPDWVKINSTKVVGRYHSPFIVEKYRCLLQLREQ--LVIDSGQEWINFLQLFGEHYYILKKAVGHLATMDCFFSLAQVAKENN---YCRPEVLEQERHI--------VIRDGRHPVIDMLMGEQDQYVPNDTELQG---DGKR-----AMIVTGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASIGM-VDGIFTRMGASDNISRGRSTFMEELLEASEILSHATSRSLVILDELGRGTSTHDGIAIAYATLEFFIRDVKCLTLFVTHYPPLCELEKLYPLHVGNYHMAFLLNEPEIVGD-------EEEVQPEFITFLYQLTEGAAGRSYGLNVARLANIPESILRTAALKSK--ELEAIINSRRRAVKG 1089
BLAST of msh6 vs. Ensembl Cavefish
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:103037699]) HSP 1 Score: 208.379 bits (529), Expect = 2.322e-54 Identity = 188/687 (27.37%), Postives = 316/687 (46.00%), Query Frame = 3
Query: 1563 AVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDI-SEIISFFKTAFDQENAKKNGKIIPESGIDADY---DESVALIKEIERDLAEYLEKQKKII-NSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDG 3596
+ CLG ++ YL + +++ L+ + F SD D HM++ + T+ NL++ N + G + G+LL LD + T FG+RLL +W++ PL +I+ RQ+A+ E++ +++ L +I+ L PDLE+ + I Y ++ T L++ + ++ +EF Q + + +I S + + P + S +F K ENA K G D+ ++ I+ I D+ E+ + + I+ N ++N+ F +E+ S S VP ++ + K RY + I + L+ ++ VI+S ++ L P + RHI +I +GR P + +++ N +L + R M++TGPNMGGKS+ +RQ AL+ I++QLG +VPA I VD +FTR GA+D+I G+ST E+ EA+ ILS+ + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E EK ++ HMA ++ + + ++ + ITFLY+LT G +SYG N ARLANIPE I+ K+K E E +I R+ + G
Sbjct: 483 VICCLGPVIQYLTEFKLERVLLCPSSFRRLL-SDSD--------------------HMVLSATTMKNLEIFCNQTTGSVKGSLLWVLDHTHTPFGKRLLKKWVSQPLKSASEILSRQEAVAEILSSESSVLPSIQALLNRLPDLERGLCSI------------------------YHKKCSTQEFYLLSS--TLSRLGIEF------QALIPAVQSQISSALLKSLLLDTPQLLSPAHNFLKVL--NENAAKTGNKTELFADLTDFPVIEQRKDQIQNILSDIMEHRRELRLILRNPSLNYATVSGQEFLIEVKNSMSSVVPPDWVKINSTKVVGRYHSPFIVEKYRCLLQLREQ------------------------LVIDSGQEWINFLQ-----------PEVLEQERHI--------VIRDGRHPVIDMLMGEQDQYVPNDTELQG---DGKR-----AMIVTGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASIGM-VDGIFTRMGASDNISRGRSTFMEELLEASEILSHATSRSLVILDELGRGTSTHDGIAIAYATLEFFIRDVKCLTLFVTHYPPLCELEKLYPLHVGNYHMAFLLNEPEIVGD-------EEEVQPEFITFLYQLTEGAAGRSYGLNVARLANIPESILRTAALKSK--ELEAIINSRRRAVKG 1053
BLAST of msh6 vs. Ensembl Sea Lamprey
Match: msh6 (mutS homolog 6 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-020905-3]) HSP 1 Score: 541.191 bits (1393), Expect = 0.000e+0 Identity = 320/784 (40.82%), Postives = 470/784 (59.95%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYT--HQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLS-KSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDA--LLSLTSFSR--GLDGGPMTRPEIR-----HINPGDKPFLIITEGRFPCKAKTQSGE-FISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGS-----GQSTLQVEMNEAALILSYMSPHSFLLIDEL-------GRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEET 3563
P +++Y +G LS TQ + LA+ ++ T + QF + TL D + S LP L +D+LG +++ E ELA+S LGA+L+YL KCLID L+S+ +F Y P D LA D YT M++D TLTNL++L++S+ GG++GTLL RLD LT FGRRLL W+ P CDP I +R A+++L+ + + +K+ L+ PDLE+L++KIH LG ++ DHPDSRAVLYE YS+RKI DF++TL F Q + +S+LLRK+ + ++D G FPD+S + + TAFD + A+ +G I P G D +YD+++ I ++ L EYLEKQ+K ++ +I ++GTG+N FQ+E+P++ + P Y S +KGF+R+ + EIE L+ L +AE++RD+ +++ M ++F FD Y QW+ ++ +A D LLSL +S G PM RP +R + G PFL + R PC + T G+ FI N + +G L + + + +L+TGPNMGGKSTLMRQ LI+I++QLGCYVPAE LTPVDR+FTR GA+D I S G+ST VE++E + IL + + HS +L+DEL GRGTATYDG A+A +++ +A+ RT+FSTH+H L+E+ ++++ HMACM+E +N D++ + ITFLYK G CPKSYGFNAARLA +P+ ++ G +KA+ FE T
Sbjct: 616 PAQVLYERGGLSAETQKIVRVTLASALQDALTPSTQFWDATKTLK---VEDERGGSGGGGGSSGALPPVLRAMTAASDSLGLAAADEAELALSALGAMLFYLRKCLIDHELLSMGNFRRYQPPD------LVLAGDAHNGGYTGLATRRMVLDGVTLTNLEVLQSSTTGGVEGTLLVRLDSCLTPFGRRLLRAWLVAPPCDPRAIDDRLDALEDLMAVPDKVLQVKDLLRKMPDLERLLSKIHGLGTPLRASRDHPDSRAVLYEETAYSKRKIADFLSTLEGFR--AASQAAGLLQECAGDFKSRLLRKV-VSTEDG--GHFPDLSPELQRWDTAFDHQKARSSGVITPRPGFDPEYDQALLDISANKKLLDEYLEKQRKRLSCKSIVYWGTGRNCFQMEVPDAVAQRNTPEEYQLKSTKKGFRRFHSPEIERLMALLSDAEERRDIAMRDCMRRLFYNFDASYKQWSAAMHCMAVLDTDVLLSLAHYSEQGGEGANPMCRPSVRPPPSEGGSSGGGPFLELRGSRHPCVSTTFLGDSFIPNDVVVG--LSDGDDDGGARCVLVTGPNMGGKSTLMRQAGLIVIMAQLGCYVPAEA-CRLTPVDRVFTRLGASDRIMSVLRRAGESTFFVELSETSSILQHATRHSLVLLDELGFLLRPRGRGTATYDGTAIASAVVHELAEGVRCRTLFSTHYHSLVEDFAASPHVRLGHMACMVEQEN-----------DDDPSQETITFLYKFVAGACPKSYGFNAARLAGLPDAVVRAGHRKAREFESST 1371 HSP 2 Score: 211.46 bits (537), Expect = 0.000e+0 Identity = 129/381 (33.86%), Postives = 206/381 (54.07%), Query Frame = 1
Query: 196 TDNKDSD-DFRNNS--RKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSK----NKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGG-LLYSFKESLIEENVKGKLKNTVNI----------GVALVNTNTGKFTIAQFADDDQRSRFRTLIS 1284
+D DSD +F+ ++ S + + E + S+ E++ + K + + ++P +T + + G+ ++ K T + + KA LS+FS + +S D + ++H ++L+ RD +RR P+YDP+++++P+SF+S TPG+++WW+IK+ +T++FFKVGKFYELYHMDA+T VSELGL +M+G +AHSGFPE +F++ +D LV KG+KVARVEQTET + M R + + +KVV RE+C++IT GT+ +S+ + G DA L + +E E G N GV V+T+ G F + QF DD SRFRTL++
Sbjct: 260 SDTDDSDAEFKPDTVDASSDEASSGVDEKEASEPESASDPESPVKKRKRTTTKAPALTPSRQPLMLGLSSVASSG----KAATPKQAQTGSNAKAKLSAFSSDTLESQ------NGGGQDGGKEGGGWDHEKLDWLRDGKRRDGKRRLQSDPEYDPSSIYVPDSFLSACTPGMRRWWEIKST-LFDTVLFFKVGKFYELYHMDALTGVSELGLLFMKGTWAHSGFPETSFARFSDGLVQKGYKVARVEQTETPDMMEARCRAMARPATKLDKVVKREVCRIITKGTQTYSILD--------------GDPSDAQNKFLLAVRE---REGPPGGSGNNSGANETGASVRTYGVCFVDTSVGVFHLGQFTDDRHCSRFRTLVA 612
BLAST of msh6 vs. Ensembl Sea Lamprey
Match: msh3 (mutS homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060526-307]) HSP 1 Score: 217.624 bits (553), Expect = 1.466e-58 Identity = 172/671 (25.63%), Postives = 307/671 (45.75%), Query Frame = 3
Query: 1566 VSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGK---IIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINS-NINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKA--KTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
++CL L++YL + +++ L ++F + + +C+ I+ T N++L +N + G + G+LL +D + T FGRR+ W+ PL I R + E++ + LS K L PDLE+ GL+ +Y R+ T + + + + + + + S LL I+L + P + + + D++ AK+ K +G S I+ + +L E+ + ++ + S ++ F +E+ S VPS ++ K R+ T + K+L +K + +F EHY + + +A D L SL + + DG RPE +K ++I GR P +++ N+ L + + R M++TGPNMGGKS+ +RQ ALI +++Q+G +VPA L+ + + TR GA+D+I G ST E++EA+ I+ + HS +++DELGRGT+T+DG A+A++ L+ T+F TH+ + E E+ + + HM+ ++ + + G ++ +L+++TFLY+LT G +SYG N ARLA IPEQ++ +K++ E
Sbjct: 300 IACLAVLIHYLTEFGLERVLYLSSNFQ-KFSMESECLH--------------------INGITQKNMELFQNQTNGKVKGSLLWAMDRTCTPFGRRMFRNWLGRPLISISDINARLDCVSEILASEHMVLSRAKELLWKLPDLER--------GLTS----------------IYHRKCSTKEFSLIASSLERLCTETHALAASAQDQLSSPLLLGILL--------DVPRRLQHVQHYTRVLDKQAAKEGDKTRLFTDLTGFPRMLRRSEE-IRAVLEELREHRTEVRRTLRSPAADYTTVSGQEFLIEVRNSMLHTVPSNWVKIGSTKAVTRFHTPFVVQKFKQLCQLREKLRIDSNAEWLGFLTQFGEHYHNFRAAVAQLATLDCLFSLAAIA-SRDGYCSIRPEFVE----EKSLIVIENGRHPVVELLMGDQNQYVPNSTHLDA---DGKR-----AMIITGPNMGGKSSYIRQVALIAVMAQMGSFVPA-SHAKLSSLHAIHTRMGASDNIYKGHSTFMEELSEASEIIRKATRHSLVILDELGRGTSTHDGIAIAYATLEYFVKEVQCLTLFVTHYPPVCEMERLNAEVVSNYHMSFLLSEPEETAQG------EDGERLESVTFLYQLTEGPAARSYGLNVARLAAIPEQVLHTAAQKSRELE 896
BLAST of msh6 vs. Ensembl Yeast
Match: MSH6 (Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002504]) HSP 1 Score: 287.73 bits (735), Expect = 1.229e-80 Identity = 223/778 (28.66%), Postives = 366/778 (47.04%), Query Frame = 3
Query: 1287 VQPNEIIYLKGNLSKNTQHV--FNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPD-ISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQ-WTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEI-----RHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVM-LLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFR 3581
V+P E++ + NLS + FNS A E ++F + T + ++SS+YF+ + P L + +G S G LLYYL +DK L+S+ + Y F Q M++D TL NL++ NS G GTL + + ++T G+R++ +W+ PL + I R ++ L++ ++ PDLE+++A+IH SR + K+ DF +TAF+ II++Q ++ ++ SK I FP+ + E + + AF+++ A I+P+ G D ++D+S+ I+E+E +L E L +K SNI + +GK + +EIP S VPS ++ + K +KRY + E+ L + + A++ + +++ +++ KFD HY W I +I+ D LL++T S L G P RP I N FL R PC T + +FI N I+LG + P + LLTG N GKST++R + +I++Q+GCYVP E V LTP+DR+ TR GAND+I G+ST VE+ E IL + S L++DELGRG ++ DG A+A S+L +A F+TH+ L + ++ M+ ++++ +N+TFLYK+ G S+G + A + I ++II N A E + +++ R
Sbjct: 500 VRPMEVVMERNNLSTLANKIVKFNSAPNAIFNEV-KAGEEFYDCDKTYAEIISSEYFS-------TEEDWPEVLKSYYDTGKKVG----------FSAFGGLLYYLKWLKLDKNLISMKNIKEY-------------------DFVKSQHSMVLDGITLQNLEIFSNSFDGSDKGTLFKLFNRAITPMGKRMMKKWLMHPLLRKNDIESRLDSVDSLLQDITLREQLEITFSKLPDLERMLARIH-------------SRTI----------KVKDFEKVITAFETIIELQDSLKNNDLKGDV-SKY------------ISSFPEGLVEAVKSWTNAFERQKAINENIIVPQRGFDIEFDKSMDRIQELEDELMEILMTYRKQFKCSNIQYKDSGKEIYTIEIPISATKNVPSNWVQMAANKTYKRYYSDEVRALARSMAEAKEIHKTLEEDLKNRLCQKFDAHYNTIWMPTIQAISNIDCLLAITRTSEYL-GAPSCRPTIVDEVDSKTNTQLNGFLKFKSLRHPCFNLGATTAKDFIPNDIELGK---------EQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAV-LTPIDRIMTRLGANDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIAESVLHHVATHIQSLGFFATHYGTLASSFKHHPQVRPLKMSILVDEAT-----------------RNVTFLYKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNLEHTSRLVKER 1176 HSP 2 Score: 127.102 bits (318), Expect = 7.216e-30 Identity = 86/250 (34.40%), Postives = 134/250 (53.60%), Query Frame = 1
Query: 583 YEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAH---SGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPG--TRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRFNLMKSFISK 1317
Y++L E RDAQRR P+YDP TL+IP S +K TP KQ+W+IK+ + I+FFK GKF+ELY DA+ A + L G A+ +G PE++F A Q + G+KVA+V+Q E++ A R E SK +V RE+ ++T G T G L + L E+ G + E+ ++ + + NT G A ++T TG+ + +F DD + ++ TL+S+ M+ + +
Sbjct: 277 YQWLVDE--RDAQRRPKSDPEYDPRTLYIPSSAWNKFTPFEKQYWEIKSK-MWDCIVFFKKGKFFELYEKDALLANALFDLKIAGGGRANMQLAGIPEMSFEYWAAQFIQMGYKVAKVDQRESMLAKEMR---EGSKG-IVKRELQCILTSGTLTDGDMLHSDLATFC-------LAIREEPGNF---YNETQLDSSTIVQKLNTKIFGAAFIDTATGELQMLEFEDDSECTKLDTLMSQVRPMEVVMER 509
BLAST of msh6 vs. Ensembl Yeast
Match: MSH3 (Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability [Source:SGD;Acc:S000000688]) HSP 1 Score: 177.178 bits (448), Expect = 1.419e-45 Identity = 185/665 (27.82%), Postives = 320/665 (48.12%), Query Frame = 3
Query: 1710 PFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN----LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQN-----IQSKLLRKIMLHSKDSKIGEFPDISEIISFFK----TAFDQENAKKNGKIIPESGIDADYDESVALIK------EIERDLAEYL-EKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAED----KRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIAD-SCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNG------LKKAKIFEEE-TLIMEFRKFLDGKNIS 3608
PF + + HM++D N+L +LD+ + GG G+L LD + T+FG R+L +WI PL D +I ER AI E I + N ++ L PDL + + +I + G + SR+++ ++ +T+F + K+ + H + + QS LL ++ S++ E +++ F +A ++N+ K +++ ++ +YD S +IK + L E L E +K + +NF + + +E+ S+ +P +I + K R+ T + L +KL +D + +L K ++KI A++ E ++ ++AQ+D +LSL + S ++ RP + +I R P ++ ++ N I M S N + ++TGPNMGGKS+ +RQ AL+ I++Q+G +VPAE + L+ + + TR GA+D I +G ST +VEM + IL + S LL+DE+GRGT T+DG A++++++K ++ S P +F+THF L E K ++ HM + E + ++ FLYKL G SYG N A+LA + + II L+K I E+ L ++ L NI+
Sbjct: 411 PFAS-KIHMLLDPNSLQSLDIFTHD--GG-KGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIEERLDAI-ECITSEINNSIFFESLNQMLNHTPDLLRTLNRI-MYGTT-------------------SRKEVYFYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLF-----SELNELLSTTQLPHFLTMINVSAVMEKNSDK--QVMDFFNLN-NYDCSEGIIKIQRESESVRSQLKEELAEIRKYLKRPYLNF--RDEVDYLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLNKITAEYTE----LRKITLNLAQYDCILSLAATSCNVN---YVRPTF----VNGQQAIIAKNARNPI-IESLDVHYVPNDI------MMSPEN--GKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAE-EIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFTTHFPMLGEIK--SPLIRNYHMDYVEEQKTGE-------------DWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEELRKESINEDALKLFSSLKRILKSDNIT 1004 HSP 2 Score: 48.9062 bits (115), Expect = 5.513e-6 Identity = 62/226 (27.43%), Postives = 101/226 (44.69%), Query Frame = 1
Query: 685 SKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRG---------------NYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHE--SSKNKVVNREICQVITPGTRG----FSLRNR-----------TCRETGQEGSEELGYIE---DAGGLLY-SFKE-SLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADD 1251
+KLTP KQ +K + + + ++ +VG Y+ + DAVT L + + G +A+ FP++ + ++LV KVA VEQ ET KH+ +SK+ V R+I V T T G F LR + R+ Q + I + G ++Y F+E +L +E ++ ++K I V LVNT+ +A+F D
Sbjct: 130 AKLTPLDKQVKDLKMH-HRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQFAYCSFPDVRLNVHLERLVHHNLKVAVVEQAETSAIK----KHDPGASKSSVFERKISNVFTKATFGVNSTFVLRGKRILGDTNSIWALSRDVHQGKVAKYSLISVNLNNGEVVYDEFEEPNLADEKLQIRIKYLQPIEV-LVNTDDLPLHVAKFFKD 349
BLAST of msh6 vs. Ensembl Yeast
Match: MSH2 (Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP [Source:SGD;Acc:S000005450]) HSP 1 Score: 158.303 bits (399), Expect = 1.144e-39 Identity = 172/601 (28.62%), Postives = 273/601 (45.42%), Query Frame = 3
Query: 1806 TLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELI---ELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKD-SKIGEFPDISEIISFF--------KTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYL--EKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKK---LINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQ-----NITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKA 3542
+L + L+ T G RLL +W+ PL + D+I +R + LI EL L++ L PD+ +L K++ G + V +Y+ +S+R I + V T+F ++ + V + ++S L + H + SK E + + + + K F++E GKI S +D DE I I D AE L + KK+ N + G +L ++K + YI S K + T +++ + + L DK+ L + I + + + + V+ A D + S S P RP++ ++ + LI R P FISN + L S +++TGPNMGGKST +RQ +I +++Q+GC+VP E I VD + R GA DS G ST VE+ E A IL S +S +++DELGRGT+TYDG LA++I + IA +F+THFH+L E E N++ H+ H++ NLK Q +IT LYK+ G +S+G + A + PE+I+ +KA
Sbjct: 337 SLFQLLNHCKTNAGVRLLNEWLKQPLTNIDEINKRHDLVDYLIDQIELRQMLTS--EYLPMIPDIRRLTKKLNKRGNLEDVLK-------IYQ---FSKR-IPEIVQVFTSF-----LEDDSPTEPVNELVRSVWLAPLSHHVEPLSKFEEMVETTVDLDAYEENNEFMIKVEFNEEL----GKI--RSKLDTLRDE----IHSIHLDSAEDLGFDPDKKLKLENHHLHGWC---MRLTRNDAKELRKHKKYIELSTVKAGIFFSTKQLKSIANETNILQKEYDKQQSALVREIINITLTYTPVFEKLSLVL---AHLDVIASFAHTS-SYAPIPYIRPKLHPMDSERRTHLI--SSRHPVLEMQDDISFISNDVTLESG--------KGDFLIITGPNMGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAI-VDAILCRVGAGDSQLKGVSTFMVEILETASILKNASKNSLIIVDELGRGTSTYDGFGLAWAIAEHIASKIGCFALFATHFHELTELSEKLPNVKNMHVV---------------AHIEKNLKEQKHDDEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKA 876
BLAST of msh6 vs. Ensembl Yeast
Match: MSH1 (DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis [Source:SGD;Acc:S000001162]) HSP 1 Score: 141.739 bits (356), Expect = 1.597e-34 Identity = 163/633 (25.75%), Postives = 290/633 (45.81%), Query Frame = 3
Query: 1734 MIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAK--------IHVLGLSKSVSDHPDSRAVLYE--GLLYS--RRKITDFVNTLTAFDNIIKIQLEF-------TRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFF-KTAFDQENAKKNGKIIPESGIDADYDESVALIKEI---ERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIE---GLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINP---GDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAK 3545
M IDS T T L+L G+LL + ++T G RLL QW++ P D +I +RQK + + ++ LK DL +++ K + ++ +++S+ + R L L+ + + +IT +L N+I L+F +QN + + R + + KD K +I E+ F +F+ + K + G+ E AL+K + + K+++ ++ GT + +++ SK ++ + Q+ R+L+ +I G +L+N + + + NI+ KF + + QV ++ D +L+SF+ + + P++ N + L++ EG +T F +N +L DN + ++TGPNMGGKST +RQ A+I+IL+Q+GC+VP + VD+LF+R G+ D + + ST VEM E + IL + S ++DE+GRGT+ +G ++A++ LK + ++ RT+F+THF + E K+I DN M+ ++ +L N + +KL G C KS A LA P + LK+A+
Sbjct: 363 MQIDSRTSTALELHSTVRDNNKKGSLLSSIRRTVTPSGTRLLSQWLSGPSLDLKEIKKRQKIVAFFKDNRDITETLRTMLKKVNDLSRILQKFSFGRGEALELIQMARSLEVSREIRKYLLNNTSLMKATLKSQITQLTESLNFEKNLIDDILKFLNEEELAKSQDAKQN--ADVTRMLDIDVKDKKESNKDEIFELRDFIVNPSFNTKLRKLHDTY---QGVWQKKTEYNALLKGFFVGDLGAKTFTLKERQNGEYALHVTGTASSLKKIDELISKSTEYHGSCFHILQKSSQTRWLSHKIWTDLGHELELLNLKIRNEEA--NIIDLFKRKFIDRSNEVRQVATTLGYLD---TLSSFAVLANERNLVCPKVDESNKLEVVNGRHLMVEEGLSARSLET----FTANNCELAK---------DN-LWVITGPNMGGKSTFLRQNAIIVILAQIGCFVPCSKARV-GIVDKLFSRVGSADDLYNEMSTFMVEMIETSFILQGATERSLAILDEIGRGTSGKEGISIAYATLKYLLENNQCRTLFATHFGQ--ELKQIIDNKCSKGMSEKVKFYQSGI---------TDLGGNNFCYNHKLKPGICTKSDAIRVAELAGFP----MEALKEAR 955
BLAST of msh6 vs. Ensembl Yeast
Match: MSH4 (Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein [Source:SGD;Acc:S000001891]) HSP 1 Score: 110.538 bits (275), Expect = 5.208e-25 Identity = 137/547 (25.05%), Postives = 240/547 (43.88%), Query Frame = 3
Query: 1713 FYTHQSHMIIDSNTLTNLDLLKNS-SLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKI--------IPESGIDADYDESVALIKEIERDLAEYLE--KQKKIINSNINFFGTGKNRFQLEIPESK----CSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPA-EGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIF-STHFHKL 3302
F ++ M+IDS T+ L+L++N GI +L + LD + T G+R L I PL D I R +A++EL D L ++ +KS PDL+KL +++ + S D + +L + L S + + D +N +Q IQS+L+ S+ KI I EI + +++ + I +S + D S + KE++ + +E K IN + N+ F L I + + +P +I+ + +K + T+ I +L ++ L+ + + ++ K H + + ++A D + SF+ L T P + L+I + R P K F+ NTI S+ + + ++TG NM GKS ++Q ALI I++Q+G +PA G PV + + NDS+ S EM E A L ++ + L++DELGRG++ DG ++ ++ + + + T+F STHF +
Sbjct: 258 FEGTENTMLIDSKTVRGLELVENKLDKNGI--SLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKANDDLLQKLRLEMKSLPDLDKLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALN--------------------DQLIQSRLI------SETKKIFNNDAIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNGLLDVSRQIYKEVKEEFFREVEDLTAKNKINLDHNY--DSARGFYLRIKRQEFTDDVATLPDVFISRTIKKNYIECTTLNIIKKNARLKEVMEEILLLSEETVDELLDKIATHISELFMIAEAVAILDLV---CSFTYNLKENNYTIPIFTN-------NLLIRDSRHPLLEKVLKN-FVPNTI--------SSTKHSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSF---PVFKRLHARVCNDSMELTSSNFGFEMKEMAYFLDDINTETLLILDELGRGSSIADGFCVSLAVTEHLLR--TEATVFLSTHFQDI 750
BLAST of msh6 vs. Ensembl Nematostella
Match: EDO38799 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBW8]) HSP 1 Score: 229.95 bits (585), Expect = 1.869e-62 Identity = 182/631 (28.84%), Postives = 301/631 (47.70%), Query Frame = 3
Query: 1707 EPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN---LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQ-SKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQ----KKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLD-GGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNP-VMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEE 3560
E F T M ++ L NL++LK S G G+LL LD + T FG+RLL +WI PL + +I ER KA+ L L ++ L +I L PDLEK + I+ Y + +F++ A + +L+ T ++ + + S +L + E PD+ + F D E A K G + + + I+EI+ AE E + + I + ++++ N F +E+ +K VP+ +I S K R+ T +E K + +K + + F Y ++ + + +A D ++SL + +R P+ + E + ++IT+GR P + +++ N N+ N + P M++TGPNMGGKS+ ++Q ALI++++Q+G +VPA V LTP+D ++TR GA+D+I G+ST VE+ E + IL+ + S +++DELGRGT+T+DG A+A++ L+ D T+F TH+ L E E+ ++ +HMA M D + + + +TFLY+L G +SYG N ARLA IP I+ K+ E E
Sbjct: 308 EKFSTIAKFMKLNGCALQNLEILK-SQCGSRKGSLLGILDHTSTPFGKRLLKRWITQPLLEKREIEERLKAVSCLSALSSDQPLLKSIHRLLSHIPDLEKGLCAIY-----------------------YKKCSTVEFLSIAKALSKL-HDELKSTELNSAKELAGSSILSRTFT--------EVPDLLSGVEDFLNQID-EKAAKCGDKTKLFTDPSKFPPVLTCIQEIDGLTAELKEHRSEIRRTIQHPSVDYCTVSGNEFLIEVRNAKLPSVPADWIKISATKQICRFRTPFVEEKFKSICQWREKLAQACQEAWLEFLDIFSTSYTRFHRAVKLVANLDCIMSLATVARQPGYVCPVIKKET------EASSVLITQGRHPVIDVLLQEHAQYVPN---------NTELNTEGPRCMIITGPNMGGKSSYIKQVALIVLMAQMGSFVPAHS-VELTPLDAIYTRMGASDNIYKGRSTFMVELQETSEILAQATRRSLVILDELGRGTSTHDGVAIAYATLRHFIDQTHSLTLFVTHYPSLAELERIFPGHVTNNHMAFMTSDGDTELASVA-------MDTPAVTFLYELVRGVAARSYGLNVARLAGIPINIVAMAAGKSHDLESE 881
BLAST of msh6 vs. Ensembl Nematostella
Match: EDO26509 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TBU4]) HSP 1 Score: 166.007 bits (419), Expect = 7.513e-46 Identity = 110/295 (37.29%), Postives = 167/295 (56.61%), Query Frame = 3
Query: 2682 QVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQ--SGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCS-PRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
Q NSIAQ D LLS F++ RP + + L I GR P K E+I+N + L NRN ++++TGPNM GKS ++RQTALI++L+Q+G YVPA+ I VD++FTR GA+D+I G+ST VEMNE A IL+ +S S +L+DE+GRGT+TYDG ++A++I + + + S +T+F+TH+H+L + E + ++ +++ LK I FL KL GG S+G + A+LA +P ++I + +KI E+
Sbjct: 7 QNANSIAQLDCLLS---FAKTAIDNNYVRPIL-----DESTDLEIKNGRHPVIEKQLPIGEEYIANDVVL-------NRN-QQQIIMITGPNMSGKSAILRQTALIVLLAQMGSYVPAQNARI-GIVDKIFTRVGASDNISMGESTFMVEMNETASILNNISERSLVLLDEIGRGTSTYDGISIAWAIAEFLHEHPSKAKTLFATHYHELNDMTETFERIKNYNVSV------------------KELK-DTIIFLRKLVAGGSNHSFGIHVAKLAGMPNRVI---HRASKILEQ 262
BLAST of msh6 vs. Ensembl Nematostella
Match: EDO38319 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD83]) HSP 1 Score: 171.4 bits (433), Expect = 8.580e-44 Identity = 171/630 (27.14%), Postives = 277/630 (43.97%), Query Frame = 3
Query: 1731 HMIIDSNTLTNLDLLKNSSLGGIDGTLLERL-DFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHS-KDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKE----------IE-----RDLAEYLEKQKKI---INSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINS-IAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
+M +D+ + L+LL N GG L L + T G+RL+ QWI PL D +KI ER ++ +E +++ +K PD +L K +A L + + ++ V L F ++++ R H + RK+++ +D + D ++ +T D E + + E I A +DE + +E +E RDL+ LE K I N+ + +F F++ E K + Y RK R+ + L + +D + V + +++ K Y + Q ++ IAQ DAL+S S P RP I G + +I+T R PC + FI+N + L + ++ + +++TGPNMGGKST +RQ +I++++QLGC+VP I + D + R G+ DS G ST EM E A IL + S ++IDELGRGT+TYDG LA++I + IA +F+THFH+L + D + H+ +T LYK+ G C +S+G + A LA+ P +I +KA E+
Sbjct: 157 YMKLDAAAVRALNLLPNPMDGGNKSMCLTGLLNKCKTPQGQRLVAQWIKQPLMDKNKIEERLNIVEAFVEDTELRQTLQDEMKKFPDFSRLAKKFQ------------RQKATLQDCV-----RVYQSVQRLEPFADVLE------RYHGDH-------RKLLVECFRDPLMELVADFAKFCDLVETTIDLEQVENH-----EYLIKATFDEGLQECREHMDEILEKFPVELNKAGRDLS--LEPSKTIKLESNNQLGYF------FRITRKEEKVLRNNKRYSTIETRKDGVRFTNSALSQLNDEFRGYKDTYNDVQGKLAAEVL-KIAGGYSEPMQGLSDVIAQIDALVSFAHVSANAPI-PYVRPTI--TPKGSEGDIILTGSRHPCLEIQDNVAFIANDVTL-----SRDKQM---FLIITGPNMGGKSTYIRQIGVIVLMAQLGCFVPCSTAQI-SITDCILARVGSGDSQLKGVSTFMSEMLETASILRTATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATQIKSFCLFATHFHEL---TSLADEV----------------STVTNLHVTALTTGGTLTLLYKVKPGVCDQSFGIHVAELAHFPSDVIEFAKQKAAELED 711
BLAST of msh6 vs. Ensembl Nematostella
Match: EDO48759 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIQ7]) HSP 1 Score: 136.732 bits (343), Expect = 1.138e-32 Identity = 158/627 (25.20%), Postives = 252/627 (40.19%), Query Frame = 3
Query: 1734 MIIDSNTLTNLDLLKNSSLGGI--DGT-------LLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKEL-----IELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPST--YIASSQRKGFKRYLTVEIEGL----------LKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCS--PRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNG 3530
+I+D NT + L + + S + GT L L+ + +A G RLL W P D + ERQKAI I+L A+L + N+K+ ++++ V P + + ++ ITD+ N + I + E I K+ + D+ I S T D +++ + + + + G+D DE K L +++ K + N+ I E +P +A + K E++GL K + D ++ + S I E V+ A+ D L+SL +R PEI K L IT G P + S +F+ N + +S R V++LTGPN GKS ++Q LI+ L+ +G +VPAE +I DRLFTR +++ G ST +++N+ A + + S +LIDE G+GTAT DG +L + L+ S S P+T+ STHFH L+ +K + D E D + + FLY L G SY + A LA +PE ++ G
Sbjct: 232 VIVDDNTYSALQIFQKESHPSVYKSGTSSKEGLSLFGVLNRTRSALGSRLLRMWFLRPTRDILVLTERQKAITFFTTPRNIDLIASLQDCLKNVKNVS------VRLYITKRELKVKSVPR----ILVRMKTAQASITDWQALYKTVYNAMYIADLCRTIPSEIAIAKKITVLVT-----------QDLHNIASLINTIIDFDDSTEQNRFVVKPGVDPALDER----KRTYNGLPDFMTKVAR----------KELNKLNPSIVECNVIYLPQLGYLLAVPRTTKMKEEKDFEMDGLDFVFLSNNMVYYKSASTRDHETAIMHRLQSTIL----ERTKVLLDVMECTAELDCLISLAVSARE---NNYVCPEI-----TSKSILHITGGMHPLQELCVS-QFVPNDTAINE---DSGR-----VVILTGPNASGKSVYLKQVGLIVFLAHIGSFVPAESAII-GVTDRLFTRIHTRETVSVGLSTFMIDLNQVASAIQSATDKSLVLIDEFGKGTATVDGLSLLCATLRHWLASSSKCPKTLVSTHFHSLIRQKLLPD-------------IPILRFQTTEVIQDG----KELVFLYHLVDGHAKTSYASHIAALAGMPEHLVKRG 784
BLAST of msh6 vs. Ensembl Nematostella
Match: EDO39460 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9X4]) HSP 1 Score: 103.99 bits (258), Expect = 2.946e-26 Identity = 54/112 (48.21%), Postives = 74/112 (66.07%), Query Frame = 3
Query: 2958 GKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHF 3293
GKST +RQ ALI IL+Q G YVPA+ + VDRLF R GA+D++ QST EM E A IL+ + S +LIDE+GRGT+ DG ++A+++ + + D RT+ STHF
Sbjct: 1 GKSTFLRQNALIAILAQAGSYVPAQQATVGI-VDRLFARIGASDNLVQHQSTFMSEMLETAYILTNATEKSLVLIDEIGRGTSMLDGMSIAWAVTEHLHDVIRCRTLASTHF 111
BLAST of msh6 vs. Ensembl Medaka
Match: msh6 (mutS homolog 6 [Source:NCBI gene;Acc:101160935]) HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0 Identity = 336/775 (43.35%), Postives = 477/775 (61.55%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFG--LPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDK--PFLIITEGRFPCKAKTQSGE-FISNTIKLGSLLMNSNRNLDN--PVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
P E+++ KGN S T+ + + L++ +E QF ++ TL L DYF E+ + G LP L K +E+D+L S + YELA+S LG ++YL KCL+DK L+S+A+F Y P D + + A F + M++D TL NL++ +N S G +GTLLERLD T FG+RLL QW+ PLC+P I +R A+++L+ A + LK PDLE+L++KIH +G DHPDSRAVLYE + YS+RKI DF++ L F + +I F V SKLLR+ ++ K + G FPD+S + + TAFD + A+ G I P++G D +YD+++A I+ ER+L +YLE+QKK + + F+GTGKNRFQ+E+P+S + +P Y S +KG KRY+T E E L +L E+KRD LK+ M ++F FD++Y W + +A D LL+++ +S+G DG PMTRPE+ GD+ PF+ + R PC KT G+ FI N I +G + +L+TGPNMGGKSTLMRQ L++IL+QLGCYVPAE + TPVDR+FTR GA+D I +G+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++K +A+ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I +G KKA+ FE T+ + K L
Sbjct: 605 PAEVLFEKGNPSVETRKILKASLSSALQEGLHGGSQFWDAQKTLKTLSEEDYFKESAGEEKQTGGCFLPALLKKMTSESDSLCLSPKEGYELALSALGGCIFYLKKCLVDKELLSMANFEEYVPVDVEMAK----AAGPSSFFAQTRLRMVLDGVTLANLEIFQNGS-GRTEGTLLERLDTCSTPFGKRLLKQWLCAPLCNPTAIKDRLDALEDLMGAQAQATEAAELLKKLPDLERLLSKIHSIGTPLKGKDHPDSRAVLYEEVTYSKRKIADFLSALEGFKTMQEIISNFA--QVSAKFGSKLLRQ-LVSLKTEEGGLFPDLSAELKRWDTAFDHQKARSTGVITPKAGFDPEYDQALAGIRSCERELNDYLERQKKRLGCKGMAFWGTGKNRFQMEVPDSVPERNIPEEYEVKSTKKGCKRYVTKETERLFSQLQGLEEKRDAALKDCMRRLFYNFDKNYGDWKTSVECMAVLDVLLAMSRYSQGGDG-PMTRPEVELPEDGDQAVPFINLVGSRHPCVTKTFFGDDFIPNDIYIGCPGNGDGLEEEGCASCVLVTGPNMGGKSTLMRQCGLVVILAQLGCYVPAES-LRFTPVDRVFTRLGASDRIMAGESTFFVELSETASILHHATKHSLVLLDELGRGTATYDGTAIASAVVKELAEKVCCRTLFSTHYHSLVEDYAKNSAVRLGHMACMVE---------NEC---EDPSQETITFLYKFISGACPKSYGFNAARLANLPEEVIQSGHKKAREFERSTVSLRLFKKL 1357 HSP 2 Score: 222.631 bits (566), Expect = 0.000e+0 Identity = 125/304 (41.12%), Postives = 182/304 (59.87%), Query Frame = 1
Query: 394 KNVNASTPHK--KKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNK---VVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
K+ A TP P + ++ +TK+ L++FS A DS E SQ ++H E+L++ +D +RR+ DYDPT+L++PE F++++TPG+++WW++K+ +T+IF+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEI F++ +D LV KG+KVARVEQTET E M R K + +K VV RE+C+++T GT+ +S+ + E+ + L S KE EE G + GV V+T+ G F + QF DD SR RTLI+ F
Sbjct: 324 KSSKAKTPAAFTATPKRAPPAVAANTKSRLTAFS--APDS-FE---SQANGPASAGAATVWDHEKLEWLQEGKRKDGKRRRQTDEDYDPTSLYVPEDFLNRITPGMRRWWQLKSE-MFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGTWAHSGFPEIGFARFSDVLVHKGYKVARVEQTETPEMMEARCKAMAKPSKFDRVVRREVCRIVTRGTQTYSVLDGAPSESQSK-------------FLLSLKEK-PEEESSGHCR---VYGVCFVDTSVGYFHVGQFPDDRHCSRLRTLIAHF 603
BLAST of msh6 vs. Ensembl Medaka
Match: msh6 (mutS homolog 6 [Source:NCBI gene;Acc:101160935]) HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0 Identity = 336/775 (43.35%), Postives = 477/775 (61.55%), Query Frame = 3
Query: 1293 PNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFG--LPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIIN-SNINFFGTGKNRFQLEIPESKCSK-VPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDK--PFLIITEGRFPCKAKTQSGE-FISNTIKLGSLLMNSNRNLDN--PVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFL 3590
P E+++ KGN S T+ + + L++ +E QF ++ TL L DYF E+ + G LP L K +E+D+L S + YELA+S LG ++YL KCL+DK L+S+A+F Y P D + + A F + M++D TL NL++ +N S G +GTLLERLD T FG+RLL QW+ PLC+P I +R A+++L+ A + LK PDLE+L++KIH +G DHPDSRAVLYE + YS+RKI DF++ L F + +I F V SKLLR+ ++ K + G FPD+S + + TAFD + A+ G I P++G D +YD+++A I+ ER+L +YLE+QKK + + F+GTGKNRFQ+E+P+S + +P Y S +KG KRY+T E E L +L E+KRD LK+ M ++F FD++Y W + +A D LL+++ +S+G DG PMTRPE+ GD+ PF+ + R PC KT G+ FI N I +G + +L+TGPNMGGKSTLMRQ L++IL+QLGCYVPAE + TPVDR+FTR GA+D I +G+ST VE++E A IL + + HS +L+DELGRGTATYDG A+A +++K +A+ RT+FSTH+H L+E+ +++ HMACM+E NEC + + ITFLYK G CPKSYGFNAARLAN+PE++I +G KKA+ FE T+ + K L
Sbjct: 523 PAEVLFEKGNPSVETRKILKASLSSALQEGLHGGSQFWDAQKTLKTLSEEDYFKESAGEEKQTGGCFLPALLKKMTSESDSLCLSPKEGYELALSALGGCIFYLKKCLVDKELLSMANFEEYVPVDVEMAK----AAGPSSFFAQTRLRMVLDGVTLANLEIFQNGS-GRTEGTLLERLDTCSTPFGKRLLKQWLCAPLCNPTAIKDRLDALEDLMGAQAQATEAAELLKKLPDLERLLSKIHSIGTPLKGKDHPDSRAVLYEEVTYSKRKIADFLSALEGFKTMQEIISNFA--QVSAKFGSKLLRQ-LVSLKTEEGGLFPDLSAELKRWDTAFDHQKARSTGVITPKAGFDPEYDQALAGIRSCERELNDYLERQKKRLGCKGMAFWGTGKNRFQMEVPDSVPERNIPEEYEVKSTKKGCKRYVTKETERLFSQLQGLEEKRDAALKDCMRRLFYNFDKNYGDWKTSVECMAVLDVLLAMSRYSQGGDG-PMTRPEVELPEDGDQAVPFINLVGSRHPCVTKTFFGDDFIPNDIYIGCPGNGDGLEEEGCASCVLVTGPNMGGKSTLMRQCGLVVILAQLGCYVPAES-LRFTPVDRVFTRLGASDRIMAGESTFFVELSETASILHHATKHSLVLLDELGRGTATYDGTAIASAVVKELAEKVCCRTLFSTHYHSLVEDYAKNSAVRLGHMACMVE---------NEC---EDPSQETITFLYKFISGACPKSYGFNAARLANLPEEVIQSGHKKAREFERSTVSLRLFKKL 1275 HSP 2 Score: 221.861 bits (564), Expect = 0.000e+0 Identity = 125/304 (41.12%), Postives = 182/304 (59.87%), Query Frame = 1
Query: 394 KNVNASTPHK--KKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNK---VVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
K+ A TP P + ++ +TK+ L++FS A DS E SQ ++H E+L++ +D +RR+ DYDPT+L++PE F++++TPG+++WW++K+ +T+IF+KVGKFYELYHMDAV V+ELGLT+M+G +AHSGFPEI F++ +D LV KG+KVARVEQTET E M R K + +K VV RE+C+++T GT+ +S+ + E+ + L S KE EE G + GV V+T+ G F + QF DD SR RTLI+ F
Sbjct: 242 KSSKAKTPAAFTATPKRAPPAVAANTKSRLTAFS--APDS-FE---SQANGPASAGAATVWDHEKLEWLQEGKRKDGKRRRQTDEDYDPTSLYVPEDFLNRITPGMRRWWQLKSE-MFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGTWAHSGFPEIGFARFSDVLVHKGYKVARVEQTETPEMMEARCKAMAKPSKFDRVVRREVCRIVTRGTQTYSVLDGAPSESQSK-------------FLLSLKEK-PEEESSGHCR---VYGVCFVDTSVGYFHVGQFPDDRHCSRLRTLIAHF 521
BLAST of msh6 vs. Ensembl Medaka
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:101156254]) HSP 1 Score: 258.07 bits (658), Expect = 1.964e-70 Identity = 197/691 (28.51%), Postives = 340/691 (49.20%), Query Frame = 3
Query: 1518 EADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDA--DYDESVALIKEIERDLAEYLEKQKKIINS-NINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHL-----DNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
++ +L R +S E + + CLG L+ YL + +++ L S + F +L+ + + MI+++ TL NL++L N + G+ G+L LD S T FGRRL+ +W++ PL D +I ERQ A++E++E D+ L ++K+ L PDLE+ + I Y ++ T +++ + + +QL+ + +S LLR ++L + PD+ F +++ A+ K S + E I + ++ E+L+ + ++ + +N+ F +E+ S S VPS ++ S K RY + + KKL ++ L + + +F EHY + I+ +A D L SL ++ G RP++ D+P ++I +GR P + +F+ N L + R M++TGPNMGGKS+ +RQ ALI I++Q+G +VPA L +D ++TR GA+D+I G+ST E+ EA+ I+S + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E E+ D++ HMA ++ E H+ D +++ + ITFLY LT G +SYG N A+LA++P+ I+ +KA+ E
Sbjct: 447 DSRSLWRVASFESPV-ICCLGPLIQYLQEFNLERVLRSESSF-------------QRLSCESEA--------MILNAATLRNLEILNNQTDRGVRGSLFWVLDHSRTPFGRRLMRKWVSQPLTDLQRISERQDAVQEIMESDSPILDSVKSLLPRLPDLERGICSI------------------------YHKKSSTQEFYLISSHLSRLGLQLQSWIPAIRSQTRSVLLRSVLLDT--------PDLLAPAHTFLNVLNEKAARSGNKTELFSDLSGFPVLQERTKQIHFVLSEIQEHLKDIRMVLKAPTLNYITVSGQEFLIEVKNSLSSTVPSDWVKISSTKAVGRYHSPLLVERYKKLQQLREQLLLDCQREWTDFLDQFGEHYHTMKRAISHLATIDCLFSLAEVAQQ---GGYCRPKVCE----DQPQIMIRDGRHPAIDLLMGEQNQFVPNHTDLQG---DGKR-----TMIITGPNMGGKSSYIRQVALICIMAQIGSFVPA-SEACLGLLDGIYTRMGASDNIYKGRSTFMEELTEASEIISRATERSLVILDELGRGTSTHDGIAIAYATLEYFIRHVKSFTLFVTHYPPLCELERMYPDHVSNFHMAFLLN----------ETHISSDTKDGDVQPEFITFLYNLTEGAAGQSYGLNVAKLADVPDPILCTAARKAQELE 1057
BLAST of msh6 vs. Ensembl Medaka
Match: msh3 (mutS homolog 3 [Source:NCBI gene;Acc:101156254]) HSP 1 Score: 221.09 bits (562), Expect = 1.696e-58 Identity = 185/691 (26.77%), Postives = 323/691 (46.74%), Query Frame = 3
Query: 1518 EADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN-LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDA--DYDESVALIKEIERDLAEYLEKQKKIINS-NINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPC--KAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLE-EKEIGDNLQISHMACMIEXXXXXXXXXXECHL-----DNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFE 3554
++ +L R +S E + + CLG L+ YL + +++ L S + F +L+ + + MI+++ TL NL++L N + G+ G+L LD S T FGRRL+ +W++ PL D +I ERQ A++E++E D+ L ++K+ L PDLE+ + I Y ++ T +++ + + +QL+ + +S LLR ++L + PD+ F +++ A+ K S + E I + ++ E+L+ + ++ + +N+ F +E+ S S VPS ++ S K RY + + KKL ++ L + +WT + P++ P ++I +GR P + +F+ N L + R + ++TGPNMGGKS+ +RQ ALI I++Q+G +VPA L +D ++TR GA+D+I G+ST E+ EA+ I+S + S +++DELGRGT+T+DG A+A++ L+ T+F TH+ L E E+ D++ HMA ++ E H+ D +++ + ITFLY LT G +SYG N A+LA++P+ I+ +KA+ E
Sbjct: 447 DSRSLWRVASFESPV-ICCLGPLIQYLQEFNLERVLRSESSF-------------QRLSCESEA--------MILNAATLRNLEILNNQTDRGVRGSLFWVLDHSRTPFGRRLMRKWVSQPLTDLQRISERQDAVQEIMESDSPILDSVKSLLPRLPDLERGICSI------------------------YHKKSSTQEFYLISSHLSRLGLQLQSWIPAIRSQTRSVLLRSVLLDT--------PDLLAPAHTFLNVLNEKAARSGNKTELFSDLSGFPVLQERTKQIHFVLSEIQEHLKDIRMVLKAPTLNYITVSGQEFLIEVKNSLSSTVPSDWVKISSTKAVGRYHSPLLVERYKKLQQLREQLLLDCQR--------------EWTDFLE-------------------------PKVCEDQPQ----IMIRDGRHPAIDLLMGEQNQFVPNHTDLQG---DGKRTM-----IITGPNMGGKSSYIRQVALICIMAQIGSFVPA-SEACLGLLDGIYTRMGASDNIYKGRSTFMEELTEASEIISRATERSLVILDELGRGTSTHDGIAIAYATLEYFIRHVKSFTLFVTHYPPLCELERMYPDHVSNFHMAFLLN----------ETHISSDTKDGDVQPEFITFLYNLTEGAAGQSYGLNVAKLADVPDPILCTAARKAQELE 1021
BLAST of msh6 vs. Ensembl Medaka
Match: msh2 (mutS homolog 2 [Source:NCBI gene;Acc:101167993]) HSP 1 Score: 159.458 bits (402), Expect = 3.270e-39 Identity = 155/600 (25.83%), Postives = 254/600 (42.33%), Query Frame = 3
Query: 1836 TAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNN--LKSCPDLEKLVAKIH------------------VLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLE---KQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINS-IAQFDAL--LSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEE 3557
T G+RL+ QWI PL D KI ER ++ + D+ L L PDL +L K H + GL + + S VL + + S +TD T + +++ L+ ++ + + ++ ++ + D+ E + + +E + GK + ES A+ L YL K++K + +N F + + SK S + Y + + E+ ++ ++K I++ Y Q ++ IAQ DA+ L+L S S + P RP I ++ G + L + + R PC FI N + + R+ ++TGPNMGGKST +RQ +I +++Q+GC+VP E L+ D + R GA DS G ST EM E A IL + +S ++IDELGRGT+TYDG LA++I + IA S +F+THFH+L ++ H+ + +T LY++ G C +S+G + A LA P ++ +KA+ EE
Sbjct: 334 TPQGQRLVNQWIKQPLMDKTKIEERLDLVESFV-CDSELRQTCQGDLLHRFPDLHRLAKKFHRHSATLQDCYRVYQAVSQIPGLIAAFEKYSGSYQVLLQAVFTS--PLTDLQTDFTKYQEMVETTLDMNQIDHHEFLVKASFDPVLTELRE----KMDDLEESMQAVLNSAARELGLEAGKTVKL--------ESNAM-------LGFYLRVTCKEEKGLRNNKKFTTLDVQKNGVRFTNSKLSSLNEEYTRNKEEY--------------------EEAQNAIVKEIIN-----IASGYVDPLQTLSDVIAQLDAVVSLALASVSAPV---PYVRPRI--LDEGCRR-LELVQARHPCMETDADTAFIPNDVSF----VQGERSF----YIITGPNMGGKSTYIRQVGVIALMAQIGCFVPCE-KAELSVTDSILARVGAGDSQVKGVSTFMSEMLETAAILRSATENSLIIIDELGRGTSTYDGFGLAWAISEHIASKISCFCLFATHFHELTALASQQPSVHNLHVTALTTH-------------------NTLTMLYRVKAGVCDQSFGIHVAELACFPPAVLAVAREKAEELEE 852
BLAST of msh6 vs. Planmine SMEST
Match: SMESG000073017.1 (SMESG000073017.1) HSP 1 Score: 1603.57 bits (4151), Expect = 0.000e+0 Identity = 790/790 (100.00%), Postives = 790/790 (100.00%), Query Frame = 3
Query: 1290 QPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDGKNISFESIKMWQNRFKKLYRI 3659
QPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEDDNDDDVGNNECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDGKNISFESIKMWQNRFKKLYRI
Sbjct: 416 QPNEIIYLKGNLSKNTQHVFNSCLAATKKECFTNNKQFLSSEDTLSRLMSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGALLYYLGKCLIDKYLVSIADFNLYYPSDGDCIQPHQLAIDDKEPFYTHQSHMIIDSNTLTNLDLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEDDNDDDVGNNECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLIMEFRKFLDGKNISFESIKMWQNRFKKLYRI 1205 HSP 2 Score: 850.507 bits (2196), Expect = 0.000e+0 Identity = 415/415 (100.00%), Postives = 415/415 (100.00%), Query Frame = 1
Query: 46 MQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNKTDKIKFKDNDSMPSTDNKDSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 1290
MQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNKTDKIKFKDNDSMPSTDNKDSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF
Sbjct: 1 MQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNKTDKIKFKDNDSMPSTDNKDSDDFRNNSRKSFKRLKALSEDDESDKENSLIFSTNKKIKVKPNYESPPMTKTENEFLSGIRKNVNASTPHKKKPTKDEKSINDSTKALLSSFSINANDSNIETNISQVIEDDFKNDIESYEHFSYEFLKKENIRDAQRRKPDHPDYDPTTLFIPESFMSKLTPGLKQWWKIKANGNMETIIFFKVGKFYELYHMDAVTAVSELGLTYMRGNYAHSGFPEIAFSKMADQLVLKGFKVARVEQTETVEAMTERIKHESSKNKVVNREICQVITPGTRGFSLRNRTCRETGQEGSEELGYIEDAGGLLYSFKESLIEENVKGKLKNTVNIGVALVNTNTGKFTIAQFADDDQRSRFRTLISRF 415
BLAST of msh6 vs. Planmine SMEST
Match: SMESG000016751.1 (SMESG000016751.1) HSP 1 Score: 163.31 bits (412), Expect = 1.086e-40 Identity = 165/617 (26.74%), Postives = 272/617 (44.08%), Query Frame = 3
Query: 1767 DLLKNSSLGGIDGTLLERLDFSLTAFGRRLLIQWIATPLCDPDKIIERQKAIKELIELDANLSNI--KNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPS-----------TYIASSQRKGFKRY---LTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVINSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLI 3569
DL K+ SL G+ L+ TA G RLL+QWI PL D + I R ++ LI D L + NL+ PDL+++ + L ++ + D +Y+ L + R+ +D +N L + K + Q+ S ++++I+ D I F + FD E K + E + D DES+ + L +E + ++ + T + +F+ +V I + + G K + +T+ E L+ + E+ +++ IM KI K+ Q + +I A+ D L SL + G G RP++ ++ + R P + +I+N I ++TGPNMGGKST +R LI +++Q+G +VP +G I + DR+ TR GA D +G ST EM + + IL + S ++IDELGRGT+T+DG LA+SI + IA + F+THFH+L + +I N+ H+ + N L F+YK+ G +SYG A+ + +P++ I L K K+ E E L+
Sbjct: 305 DLRKHDSLYGL-------LNCCRTASGERLLLQWIKQPLMDVNLINNRLDIVESLIN-DNKLRGCLYEENLRRIPDLQRITRR-----LQRNKGNLQD----IYK-LYVALRQASDMLNLLNEHNGPYKC--------IIQSELSSVIQEIL-----------KDTENFIQMFTSFFDFEAVKNH-----EFKVKCDVDESLKECENSMITLKSQMETESSRVSDKLGIESTKQLKFESSNSLGYYMRVSRKDENVLRNKSFISIIETLKDGVKFHSTQMTLMNESYLQHRRDYEEYERSIIEEIM-KITNKYVGSLHQLSSII---AKLDVLCSLATMVCGA-PGTYARPKV--VDDCKTRVFKVKNCRHPLVEMQNNMSYIANDISFDE---------SRTFQIITGPNMGGKSTYIRSIGLISVMAQIGSFVPCDGAEI-SIFDRIMTRIGAGDCQLTGVSTFMAEMLDISWILKTATSKSLIIIDELGRGTSTFDGFGLAWSISEHIATELKAFSAFATHFHELTDLSKIHCNVNNLHVTAQT--------------IGNEL-----IFMYKVEEGPAVRSYGIEVAKASGLPDESI--KLAKLKLSEYENLM 841
BLAST of msh6 vs. Planmine SMEST
Match: SMESG000019325.1 (SMESG000019325.1) HSP 1 Score: 114.005 bits (284), Expect = 3.214e-27 Identity = 85/267 (31.84%), Postives = 133/267 (49.81%), Query Frame = 3
Query: 2781 HINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIADSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPK-SYGFNAARLANIPEQIILNGLK-KAKIFEEETLIME 3575
+I P L I R P + + E ISN + NL N ++TG NM GKS +RQ AL+ I+ Q+GC++PAE D LFTR G +D I S ST +EM E + I++ ++ +S +LIDELGRGT+ +G + F+I + + + +THF +L + + + N+Q + E N + +E HL F YK G CP + A+L+N+P+Q++ K ++ + LI+E
Sbjct: 4 YIRPEFTDTLAIKNCRNPLLDRLSNKETISNHVYAA--------NLSN-FTIVTGANMSGKSMYLRQIALVQIMGQIGCFIPAEYASFRLS-DHLFTRIGVDDDIQSNSSTFTIEMREMSYIINTITDNSLVLIDELGRGTSFDEGLGICFAICEHLLQT-KAFIFIATHFRELSKLEILYPNVQNVNF----EVKNLSESDGDENHL---------LFTYKCVRGVCPDFTNAMKLAKLSNLPKQLLFEAEKIYGRLGDSNELIIE 246
BLAST of msh6 vs. Planmine SMEST
Match: SMESG000006277.1 (SMESG000006277.1) HSP 1 Score: 107.071 bits (266), Expect = 2.481e-23 Identity = 147/640 (22.97%), Postives = 265/640 (41.41%), Query Frame = 3
Query: 1716 YTHQSHMIIDSNTLTNLDLL-KNSSLGGIDGTLLERLDFSLTAF----------GRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN---LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGTGKNRFQLEIPESKCSKVPSTYIASSQRKGFKRYLTVEIEGL--LKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVI----NSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIA--DSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLI 3569
YT M ID N+L LD+ K S G + + L+ F +L W+ PL D I +R + + + N L + LK ++++++ L + S + PD ++ + I ++ F + IK LE ++Q I++K K+ L I S+ D E +K + + + G+D DE + + L+ E++ K N++I G + +P+ Y+ + + + + I G+ L + NA ++ KN+ + I E ++T ++ + + + D LLSL +R + G TRP G+ + I GR P + + S FI N+ + + D + +++G N GKS ++Q ++I+L+Q+G +VPA + LTP + L TR + +S SG ST V++N+ +L + HS +LIDE G+G G +L + L+ + S P THFH+L + +Q + + + K + +LY+L G S+ AARL N+ + I+ ++ + F + I
Sbjct: 43 YTTAKTMFIDENSLKALDIFNKVSHPSGFKQGVKKDTKEGLSIFHLLNNCHSKMASDMLHSWLRRPLTDISMIQKRLDCV-DFFQNSQNQDVLQILLRKLKGVGNIKQIL-----LRMKNSTALLPDWNVLI--------QSIAGLISIFEIF-SAIKEPLE-----IKQKIEAKFTDKLYL---------------IASWITKIIDTEGIEKQKRFVVKEGVDPYLDEKKSKYYHLPDLLSALAEEELKGFNNDIQICGI------VYLPQV-------GYLLTIPIENNENEQKINIPGMEYLFSMNNAVYYKNYTTKNLETSIMHCLQESILEYTHMLLNCLDLVLELDCLLSLAIAARQIGG---TRPLFE--TSGE---IKIENGRHPLQ-EVFSNPFIPNS--------TYSNDWDGKLTIISGANGSGKSVYLKQIGILIVLAQIGSFVPAT-KMSLTPQNALLTRLKSLESSLSGLSTFMVDLNQISLCCKKANAHSTILIDEFGKGAEMKSGISLIVAFLRFMVAKKSECPHIFVVTHFHRLFSLIQDLPKVQFKNFNVIED------------------KHSQLIYLYQLVDGHIECSHAIQAARLVNVSDNILQRAIEVSDSFAKNKTI 598
BLAST of msh6 vs. Planmine SMEST
Match: SMESG000006277.1 (SMESG000006277.1) HSP 1 Score: 104.375 bits (259), Expect = 1.527e-22 Identity = 149/648 (22.99%), Postives = 267/648 (41.20%), Query Frame = 3
Query: 1716 YTHQSHMIIDSNTLTNLDLL-KNSSLGGIDGTLLERLDFSLTAF----------GRRLLIQWIATPLCDPDKIIERQKAIKELIELDAN---LSNIKNNLKSCPDLEKLVAKIHVLGLSKSVSDHPDSRAVLYEGLLYSRRKITDFVNTLTAFDNIIKIQLEFTRMHVEQNIQSKLLRKIMLHSKDSKIGEFPDISEIISFFKTAFDQENAKKNGKIIPESGIDADYDESVALIKEIERDLAEYLEKQKKIINSNINFFGT---GKNRFQLEIP------ESKCSKVPSTYIASSQRKGF-KRYLTVEIEGLLKKLINAEDKRDLVLKNIMSKIFAKFDEHYFQWTQVI----NSIAQFDALLSLTSFSRGLDGGPMTRPEIRHINPGDKPFLIITEGRFPCKAKTQSGEFISNTIKLGSLLMNSNRNLDNPVMLLTGPNMGGKSTLMRQTALIIILSQLGCYVPAEGPVILTPVDRLFTRQGANDSIGSGQSTLQVEMNEAALILSYMSPHSFLLIDELGRGTATYDGCALAFSILKRIA--DSCSPRTIFSTHFHKLLEEKEIGDNLQISHMACMIEXXXXXXXXXXECHLDNNLKLQNITFLYKLTHGGCPKSYGFNAARLANIPEQIILNGLKKAKIFEEETLI 3569
YT M ID N+L LD+ K S G + + L+ F +L W+ PL D I +R + + + N L + LK ++++++ L + S + PD ++ + I ++ F + IK LE ++Q I++K K+ L I S+ D E +K + + + G+D DE + + L+ E++ K N++I G + + L IP E K + Y+ S + K Y T +++ ++ +K++ + I E ++T ++ + + + D LLSL +R + G TRP G+ + I GR P + + S FI N+ + + D + +++G N GKS ++Q ++I+L+Q+G +VPA + LTP + L TR + +S SG ST V++N+ +L + HS +LIDE G+G G +L + L+ + S P THFH+L + +Q + + + K + +LY+L G S+ AARL N+ + I+ ++ + F + I
Sbjct: 43 YTTAKTMFIDENSLKALDIFNKVSHPSGFKQGVKKDTKEGLSIFHLLNNCHSKMASDMLHSWLRRPLTDISMIQKRLDCV-DFFQNSQNQDVLQILLRKLKGVGNIKQIL-----LRMKNSTALLPDWNVLI--------QSIAGLISIFEIF-SAIKEPLE-----IKQKIEAKFTDKLYL---------------IASWITKIIDTEGIEKQKRFVVKEGVDPYLDEKKSKYYHLPDLLSALAEEELKGFNNDIQICGIVYLPQVGYLLTIPIENNENEQKINIPGMEYLFSMNNAVYYKNYTTKKLDKEFGDILYE-------IKDLETSIMHCLQESILEYTHMLLNCLDLVLELDCLLSLAIAARQIGG---TRPLFE--TSGE---IKIENGRHPLQ-EVFSNPFIPNS--------TYSNDWDGKLTIISGANGSGKSVYLKQIGILIVLAQIGSFVPAT-KMSLTPQNALLTRLKSLESSLSGLSTFMVDLNQISLCCKKANAHSTILIDEFGKGAEMKSGISLIVAFLRFMVAKKSECPHIFVVTHFHRLFSLIQDLPKVQFKNFNVIED------------------KHSQLIYLYQLVDGHIECSHAIQAARLVNVSDNILQRAIEVSDSFAKNKTI 612 The following BLAST results are available for this feature:
BLAST of msh6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of msh6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of msh6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of msh6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of msh6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of msh6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of msh6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of msh6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of msh6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of msh6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of msh6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of msh6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of msh6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of msh6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30027419 ID=SMED30027419|Name=msh6|organism=Schmidtea mediterranea sexual|type=transcript|length=3719bpback to top protein sequence of SMED30027419-orf-1 >SMED30027419-orf-1 ID=SMED30027419-orf-1|Name=SMED30027419-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=743bp MSSDYFAETPANKLSRFGLPNGLTKTLNEADNLGRSSSKEYELAVSCLGAback to top protein sequence of SMED30027419-orf-2 >SMED30027419-orf-2 ID=SMED30027419-orf-2|Name=SMED30027419-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=478bp RNFLKYRPLFQSLIKMQKSILSFFPKTPSSKNKQTDILNIETANSKSKVNback to top Aliases
The feature 'msh6' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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