activin receptor-1

Overview
Nameactivin receptor-1 (AFJ24728.1)
Smed IDSMED30027370
Length (bp)1836
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of activin receptor-1 (SMED30027370) t-SNE clustered cells

Violin plots show distribution of expression levels for activin receptor-1 (SMED30027370) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of activin receptor-1 (SMED30027370) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for activin receptor-1 (SMED30027370) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30027370

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30027370SMESG000019732.1 SmedASXL_011808SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
protonephridiaSMED30027370SMESG000019732.1 dd_Smed_v4_6924_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30027370SMESG000019732.1 dd_Smed_v4_6924_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30027370SMESG000019732.1 dd_Smed_v4_6924_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of activin receptor-1 vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171])

HSP 1 Score: 330.872 bits (847), Expect = 5.806e-106
Identity = 210/533 (39.40%), Postives = 287/533 (53.85%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  +       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171])

HSP 1 Score: 330.872 bits (847), Expect = 5.806e-106
Identity = 210/533 (39.40%), Postives = 287/533 (53.85%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  +       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171])

HSP 1 Score: 330.872 bits (847), Expect = 5.806e-106
Identity = 210/533 (39.40%), Postives = 287/533 (53.85%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  +       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171])

HSP 1 Score: 330.872 bits (847), Expect = 5.806e-106
Identity = 210/533 (39.40%), Postives = 287/533 (53.85%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  +       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171])

HSP 1 Score: 330.872 bits (847), Expect = 5.806e-106
Identity = 210/533 (39.40%), Postives = 287/533 (53.85%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  +       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Celegans
Match: sma-6 (Serine/threonine-protein kinase sma-6 [Source:UniProtKB/Swiss-Prot;Acc:Q09488])

HSP 1 Score: 202.601 bits (514), Expect = 8.852e-57
Identity = 132/371 (35.58%), Postives = 187/371 (50.40%), Query Frame = 3
Query:  666 SGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRF-GCTQLWLITHYHALGSLYDYL-HSTVISFNECVSLLHSTAAGLSHLHTEI-ISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEV------------------------------------------LTRTFLSGQKTIMEYKV---PYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVL-ELNAMIRESW 1625
            SGSGSG   L+QRT+ + + +I  IG+GR+GEV K  Y G  VAVK F + DE SW  E  +Y + ++ H NIL + A+D+ S     T++ LIT YH LGSL DYL     ++ +E + L+HS   G+ HLH  +  +G   KP IAHRD+KSKNI++ +P   CIADLGL+ L+   + + P   N   ++GT+RYMAPE++++ L P                              F  F  ADIY+ ALVMWEV                                          L +T + G  T ++ K    P+  IV  DP+  EM  ++CV + RP  PD   K+V  L EL+ ++ +SW
Sbjct:  247 SGSGSGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLTTDEALRLIHSCICGIEHLHAAVHGTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLA-LRYQNDKILPEKFNV--QVGTKRYMAPELISNKLNPKD----------------------------FSQFKMADIYSMALVMWEVAIRVEVNTCEEVLTVDETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDVICVRRIRPP-PDLAWKNVPALNELSKLMEDSW 585          
BLAST of activin receptor-1 vs. Ensembl Celegans
Match: daf-1 (Cell surface receptor daf-1 [Source:UniProtKB/Swiss-Prot;Acc:P20792])

HSP 1 Score: 199.134 bits (505), Expect = 3.072e-55
Identity = 116/305 (38.03%), Postives = 164/305 (53.77%), Query Frame = 3
Query:  663 TSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQG-KPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTR----TFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRP 1562
            TSGSG G   L + TI  Q++L   +G GRFG V +G Y GE VAVK+F++ DE ++ +ET I+ + +LRHPN+L Y  SD V     T+LWL+T YH  GSL+D+L    ++     +L+ STA+GL+ LH +I    +  KP++AHRD+KSKNI++       I DLGLS L    +       N  +K GT RY+APEIL   +     FT+                        FE +  AD+Y+F+LVMWE L R      L  +   +   +PY +    DP   +M  +VC  + RP
Sbjct:  274 TSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLS-LSKPEDAASDIIANENYKCGTVRYLAPEILNSTM----QFTV------------------------FESYQCADVYSFSLVMWETLCRCEDGDVLPREAATV---IPYIEWTDRDPQDAQMFDVVCTRRLRP 546          
BLAST of activin receptor-1 vs. Ensembl Celegans
Match: daf-1 (Cell surface receptor daf-1 [Source:UniProtKB/Swiss-Prot;Acc:P20792])

HSP 1 Score: 195.667 bits (496), Expect = 5.129e-54
Identity = 116/305 (38.03%), Postives = 164/305 (53.77%), Query Frame = 3
Query:  663 TSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQG-KPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTR----TFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRP 1562
            TSGSG G   L + TI  Q++L   +G GRFG V +G Y GE VAVK+F++ DE ++ +ET I+ + +LRHPN+L Y  SD V     T+LWL+T YH  GSL+D+L    ++     +L+ STA+GL+ LH +I    +  KP++AHRD+KSKNI++       I DLGLS L    +       N  +K GT RY+APEIL   +     FT+                        FE +  AD+Y+F+LVMWE L R      L  +   +   +PY +    DP   +M  +VC  + RP
Sbjct:  274 TSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLS-LSKPEDAASDIIANENYKCGT-RYLAPEILNSTM----QFTV------------------------FESYQCADVYSFSLVMWETLCRCEDGDVLPREAATV---IPYIEWTDRDPQDAQMFDVVCTRRLRP 545          
BLAST of activin receptor-1 vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488])

HSP 1 Score: 124.02 bits (310), Expect = 1.191e-29
Identity = 99/319 (31.03%), Postives = 152/319 (47.65%), Query Frame = 3
Query:  738 IGKGRFGEVWKGAYY---GE--MVAVKIFSSRDETSWARETHIY---NSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTE--IISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS----STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            I KGRFG+V+K  Y    GE  +VAVK  +   + S+  E  I+   N Y   + +I+ +  ++ +      + W++T +H   SLY+ L + VIS      ++ S   GL  LH +     G   KP I HRD+KSKNIL+      CIAD GL+ + S     ++ L         ++GT+RYM+PE+L       T+FT       PT+                  F + D+Y+  LVMWEV++RT L        Y++P+Q ++  DP+   MR  V   K RP+  D   K  ++  L  +  E W  ++  R
Sbjct:  160 ISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIG----DEYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKP-IIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLG--------QVGTKRYMSPEMLEGA----TEFT-------PTA------------------FKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPFQ-VIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACAR 435          
BLAST of activin receptor-1 vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488])

HSP 1 Score: 123.25 bits (308), Expect = 1.336e-29
Identity = 99/319 (31.03%), Postives = 152/319 (47.65%), Query Frame = 3
Query:  738 IGKGRFGEVWKGAYY---GE--MVAVKIFSSRDETSWARETHIY---NSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTE--IISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS----STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            I KGRFG+V+K  Y    GE  +VAVK  +   + S+  E  I+   N Y   + +I+ +  ++ +      + W++T +H   SLY+ L + VIS      ++ S   GL  LH +     G   KP I HRD+KSKNIL+      CIAD GL+ + S     ++ L         ++GT+RYM+PE+L       T+FT       PT+                  F + D+Y+  LVMWEV++RT L        Y++P+Q ++  DP+   MR  V   K RP+  D   K  ++  L  +  E W  ++  R
Sbjct:   93 ISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIG----DEYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKP-IIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLG--------QVGTKRYMSPEMLEGA----TEFT-------PTA------------------FKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPFQ-VIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACAR 368          
BLAST of activin receptor-1 vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0088833)

HSP 1 Score: 307.375 bits (786), Expect = 6.445e-97
Identity = 161/332 (48.49%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD--SKSVFVLELNAMIRESWSEKSQTR 1646
            S TSGSGSG+P LVQRT+A+QV LI  IG+G++GEVW+G ++GE +AVKIF SRDE SW RET IY++ LLRH NILG+  SDM SR  CTQLWL+THY+ LGSL+D+L+   +S N+ V +  S A GL HLHTEI  G QGKP++AHRDLKSKNIL+   G   IAD GL+V  S         + +  K+GT+RYMAPE+L      D    +E C                     FE     DIYAF LV+WEV  RT   G     EYKVP+ D+VP+DPS  +MR++VC+D +RP +P+  S    +  ++ +++E W +    R
Sbjct:  208 SVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQL--DLGNNPKVGTKRYMAPEVL------DESIDLE-C---------------------FEALRRTDIYAFGLVLWEVCRRTISCG--IAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVR 506          
BLAST of activin receptor-1 vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0088832)

HSP 1 Score: 307.375 bits (786), Expect = 1.444e-96
Identity = 161/332 (48.49%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD--SKSVFVLELNAMIRESWSEKSQTR 1646
            S TSGSGSG+P LVQRT+A+QV LI  IG+G++GEVW+G ++GE +AVKIF SRDE SW RET IY++ LLRH NILG+  SDM SR  CTQLWL+THY+ LGSL+D+L+   +S N+ V +  S A GL HLHTEI  G QGKP++AHRDLKSKNIL+   G   IAD GL+V  S         + +  K+GT+RYMAPE+L      D    +E C                     FE     DIYAF LV+WEV  RT   G     EYKVP+ D+VP+DPS  +MR++VC+D +RP +P+  S    +  ++ +++E W +    R
Sbjct:  243 SVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQL--DLGNNPKVGTKRYMAPEVL------DESIDLE-C---------------------FEALRRTDIYAFGLVLWEVCRRTISCG--IAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVR 541          
BLAST of activin receptor-1 vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0308825)

HSP 1 Score: 307.76 bits (787), Expect = 1.608e-96
Identity = 161/332 (48.49%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD--SKSVFVLELNAMIRESWSEKSQTR 1646
            S TSGSGSG+P LVQRT+A+QV LI  IG+G++GEVW+G ++GE +AVKIF SRDE SW RET IY++ LLRH NILG+  SDM SR  CTQLWL+THY+ LGSL+D+L+   +S N+ V +  S A GL HLHTEI  G QGKP++AHRDLKSKNIL+   G   IAD GL+V  S         + +  K+GT+RYMAPE+L      D    +E C                     FE     DIYAF LV+WEV  RT   G     EYKVP+ D+VP+DPS  +MR++VC+D +RP +P+  S    +  ++ +++E W +    R
Sbjct:  255 SVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQL--DLGNNPKVGTKRYMAPEVL------DESIDLE-C---------------------FEALRRTDIYAFGLVLWEVCRRTISCG--IAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVR 553          
BLAST of activin receptor-1 vs. Ensembl Fly
Match: babo (gene:FBgn0011300 transcript:FBtr0088659)

HSP 1 Score: 270.396 bits (690), Expect = 4.477e-82
Identity = 147/324 (45.37%), Postives = 199/324 (61.42%), Query Frame = 3
Query:  663 TSGSGS-GMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESW 1625
            TSGSGS G+P LVQR+IARQVQL + IGKGRFGEVW+G + GE VAVKIFSSR+E SW RE  IY + +LRH NILG+ A+D       TQLWL+T YH  GSL+DYL +  +  N  +++  S A GL+HLH +I+ G +GKP+IAHRDLKSKNIL+       I DLGL+V     N     P  S H++GT+RYMAPE+L + +                        QH      F+ +  AD+YAF L++WE+  R  +       EY++PY D+V  DPS  EM+++VC++K RP +P+    S  +  +  +++E W
Sbjct:  283 TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIV-GTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIP--STHRVGTKRYMAPEVLDESMN----------------------DQH------FDSYKRADVYAFGLILWEIARRCNMG--MIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECW 573          
BLAST of activin receptor-1 vs. Ensembl Fly
Match: babo (gene:FBgn0011300 transcript:FBtr0300599)

HSP 1 Score: 269.626 bits (688), Expect = 6.628e-82
Identity = 147/324 (45.37%), Postives = 199/324 (61.42%), Query Frame = 3
Query:  663 TSGSGS-GMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESW 1625
            TSGSGS G+P LVQR+IARQVQL + IGKGRFGEVW+G + GE VAVKIFSSR+E SW RE  IY + +LRH NILG+ A+D       TQLWL+T YH  GSL+DYL +  +  N  +++  S A GL+HLH +I+ G +GKP+IAHRDLKSKNIL+       I DLGL+V     N     P  S H++GT+RYMAPE+L + +                        QH      F+ +  AD+YAF L++WE+  R  +       EY++PY D+V  DPS  EM+++VC++K RP +P+    S  +  +  +++E W
Sbjct:  277 TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIV-GTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIP--STHRVGTKRYMAPEVLDESM----------------------NDQH------FDSYKRADVYAFGLILWEIARRCNMG--MIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECW 567          
BLAST of activin receptor-1 vs. Ensembl Zebrafish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9])

HSP 1 Score: 316.62 bits (810), Expect = 8.080e-101
Identity = 202/538 (37.55%), Postives = 283/538 (52.60%), Query Frame = 3
Query:   60 EMQISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKS--LVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYY---SLSIKFVI-PFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            ++ I C+C  + C E++C T   C+  + +  ND       CL         C  +  +  +V+CC  ++CN N +    ++    S  ++   +    + + FV+ PF V  ++  +  L+    +H  L R                  L E  TE                          GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYDYL    +   + + +  S A+GL HLHTEI  G +GKP+IAHRDLKSKNIL+ K  + CIADLGL+V  + S N L    V +  K+GT+RYMAPE+L + +  D                             F+ +   DI+AF LV+WE+  RT  +G   + EYK P+ D+VP DPS  +MR++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:   23 DVSIDCMCVGSDCNEQQC-TGDQCYTSV-IISNDVTTFKRGCLIGPASKRMTCSATASASHVVECCSQHMCNANVSKETLLRLLLTSPEEKKTVHYRVEMLVLFVLGPFVVLGLLSFLALLVCRRLHHGRLER------------------LHEFDTEQGAI---------------------DGLIASNVGDSTL---ADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIF-GTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQL---DVGNNPKVGTKRYMAPEVLDETIQTDC----------------------------FDAYKRVDIWAFGLVLWEIARRTISNG--IVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSAR 482          
BLAST of activin receptor-1 vs. Ensembl Zebrafish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9])

HSP 1 Score: 316.62 bits (810), Expect = 8.080e-101
Identity = 202/538 (37.55%), Postives = 283/538 (52.60%), Query Frame = 3
Query:   60 EMQISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKS--LVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYY---SLSIKFVI-PFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            ++ I C+C  + C E++C T   C+  + +  ND       CL         C  +  +  +V+CC  ++CN N +    ++    S  ++   +    + + FV+ PF V  ++  +  L+    +H  L R                  L E  TE                          GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYDYL    +   + + +  S A+GL HLHTEI  G +GKP+IAHRDLKSKNIL+ K  + CIADLGL+V  + S N L    V +  K+GT+RYMAPE+L + +  D                             F+ +   DI+AF LV+WE+  RT  +G   + EYK P+ D+VP DPS  +MR++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:   23 DVSIDCMCVGSDCNEQQC-TGDQCYTSV-IISNDVTTFKRGCLIGPASKRMTCSATASASHVVECCSQHMCNANVSKETLLRLLLTSPEEKKTVHYRVEMLVLFVLGPFVVLGLLSFLALLVCRRLHHGRLER------------------LHEFDTEQGAI---------------------DGLIASNVGDSTL---ADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIF-GTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQL---DVGNNPKVGTKRYMAPEVLDETIQTDC----------------------------FDAYKRVDIWAFGLVLWEIARRTISNG--IVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSAR 482          
BLAST of activin receptor-1 vs. Ensembl Zebrafish
Match: acvrl1 (activin A receptor like type 1 [Source:ZFIN;Acc:ZDB-GENE-021003-1])

HSP 1 Score: 308.916 bits (790), Expect = 7.191e-98
Identity = 158/332 (47.59%), Postives = 216/332 (65.06%), Query Frame = 3
Query:  660 CTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            CTSGSG+G+P+LVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+  LRH NILG+ ASDM S+   TQLWL+TH+H LGSLYD+L  + +    C+ +  S A+GL HLHTEI+S  QGKP+IAHRDLKS+NIL+ + G+ CIADLGL+V+ S ST+ L    V +  ++GT+RYMAPE+L + +  D                             FE +   DI+A  LV+WE+  RT ++G   + EY+ P+ D+VP DPS  EM+++VCVD+ RP L +       +  +  +++E W +    R
Sbjct:  177 CTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIASGLVHLHTEILS-TQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYL---DVGTNPRVGTKRYMAPEVLDETIRVDV----------------------------FESYKQTDIWALGLVLWEITRRTIVNG--IVEEYRPPFFDMVPSDPSFEEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSAR 474          
BLAST of activin receptor-1 vs. Ensembl Zebrafish
Match: acvrl1 (activin A receptor like type 1 [Source:ZFIN;Acc:ZDB-GENE-021003-1])

HSP 1 Score: 308.531 bits (789), Expect = 9.381e-98
Identity = 158/332 (47.59%), Postives = 216/332 (65.06%), Query Frame = 3
Query:  660 CTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            CTSGSG+G+P+LVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+  LRH NILG+ ASDM S+   TQLWL+TH+H LGSLYD+L  + +    C+ +  S A+GL HLHTEI+S  QGKP+IAHRDLKS+NIL+ + G+ CIADLGL+V+ S ST+ L    V +  ++GT+RYMAPE+L + +  D                             FE +   DI+A  LV+WE+  RT ++G   + EY+ P+ D+VP DPS  EM+++VCVD+ RP L +       +  +  +++E W +    R
Sbjct:  174 CTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIASGLVHLHTEILS-TQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYL---DVGTNPRVGTKRYMAPEVLDETIRVDV----------------------------FESYKQTDIWALGLVLWEITRRTIVNG--IVEEYRPPFFDMVPSDPSFEEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSAR 471          
BLAST of activin receptor-1 vs. Ensembl Zebrafish
Match: tgfbr1a (transforming growth factor, beta receptor 1 a [Source:ZFIN;Acc:ZDB-GENE-051120-75])

HSP 1 Score: 298.901 bits (764), Expect = 5.190e-94
Identity = 198/531 (37.29%), Postives = 265/531 (49.91%), Query Frame = 3
Query:   78 ICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKES----IHDSYICQNSTKSLVK-CCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS-KSVFVLELNAMI-RESWSEKSQTR 1646
            +C    C  + C T   CF +I+     T      C+++         + C  S       CC+ ++CNKN        P  I    E +  S+S     P  +AAMI + IC++ F          L  Y     S  ++     E+ T   P+  D                                    L  D  TSGSGSG+P LVQRTIAR + L   IGKGRFGEVW+G + GE VAVKIFSSR+E SW RE  IY + +LRH NILG+ A+D       TQLWL++ YH  GSL+DYL+   ++    + L  STA+GL+HLH EI+ G QGKP+IAHRDLKSKNIL+ K G  CIADLGL+V   S+T+ +  +P    H++GT+RYMAPE+L D +                        +H      FE F  ADIYA  LV WE+  R  + G     +Y++PY D+VP DPS  +M+++VC  K RP +P+  +S   L + A I RE W      R
Sbjct:   33 LCYCERCVNRSCNTTGLCFAVIAKSSGQTVTQEHQCIQQDDLYPRDRPFQCAPSNNGKHPYCCNTHMCNKN--------PKVIPELPEAEPQSMS-----PIALAAMIAVPICVLSF-------VLVLLFYMCHNRSIIHHRVPSEEDPTMDHPFLADG------------------------------TTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIV-GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAP---NHRVGTKRYMAPEVLDDSI----------------------NMRH------FESFKRADIYALGLVFWEIARRCSIGGIHE--DYQLPYYDLVPSDPSVEDMKRVVCDQKLRPNIPNRWQSCEALRVMAKIMRECWYANGGAR 479          
BLAST of activin receptor-1 vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111])

HSP 1 Score: 324.709 bits (831), Expect = 2.734e-104
Identity = 170/334 (50.90%), Postives = 220/334 (65.87%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET +YN+ LLRH NILG+ ASDM SR   TQLWLITHYH LGSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+I+HRDLKSKN+L+ K G+ CIADLGL+V+ S +TN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DIYAF LV+WEV  R   +G   + EYK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:  146 SCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIF-GTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIYAFGLVLWEVARRMVSNG--IVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSAR 444          
BLAST of activin receptor-1 vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111])

HSP 1 Score: 325.479 bits (833), Expect = 5.761e-104
Identity = 170/334 (50.90%), Postives = 220/334 (65.87%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET +YN+ LLRH NILG+ ASDM SR   TQLWLITHYH LGSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+I+HRDLKSKN+L+ K G+ CIADLGL+V+ S +TN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DIYAF LV+WEV  R   +G   + EYK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:  184 SCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIF-GTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIYAFGLVLWEVARRMVSNG--IVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSAR 482          
BLAST of activin receptor-1 vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111])

HSP 1 Score: 325.479 bits (833), Expect = 5.996e-104
Identity = 170/334 (50.90%), Postives = 220/334 (65.87%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET +YN+ LLRH NILG+ ASDM SR   TQLWLITHYH LGSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+I+HRDLKSKN+L+ K G+ CIADLGL+V+ S +TN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DIYAF LV+WEV  R   +G   + EYK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:  185 SCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIF-GTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIYAFGLVLWEVARRMVSNG--IVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSAR 483          
BLAST of activin receptor-1 vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111])

HSP 1 Score: 325.094 bits (832), Expect = 7.729e-104
Identity = 170/334 (50.90%), Postives = 220/334 (65.87%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET +YN+ LLRH NILG+ ASDM SR   TQLWLITHYH LGSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+I+HRDLKSKN+L+ K G+ CIADLGL+V+ S +TN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DIYAF LV+WEV  R   +G   + EYK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:  186 SCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIF-GTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIYAFGLVLWEVARRMVSNG--IVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSAR 484          
BLAST of activin receptor-1 vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111])

HSP 1 Score: 325.094 bits (832), Expect = 8.874e-104
Identity = 170/334 (50.90%), Postives = 220/334 (65.87%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET +YN+ LLRH NILG+ ASDM SR   TQLWLITHYH LGSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+I+HRDLKSKN+L+ K G+ CIADLGL+V+ S +TN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DIYAF LV+WEV  R   +G   + EYK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:  190 SCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIF-GTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIYAFGLVLWEVARRMVSNG--IVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSAR 488          
BLAST of activin receptor-1 vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911])

HSP 1 Score: 327.02 bits (837), Expect = 1.112e-104
Identity = 210/534 (39.33%), Postives = 286/534 (53.56%), Query Frame = 3
Query:   75 CICNYAHCF-EKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  E  C+    CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL   L                     ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGK +IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQ-QCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACIL--------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911])

HSP 1 Score: 327.02 bits (837), Expect = 1.112e-104
Identity = 210/534 (39.33%), Postives = 286/534 (53.56%), Query Frame = 3
Query:   75 CICNYAHCF-EKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  E  C+    CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL   L                     ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGK +IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQ-QCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACIL--------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911])

HSP 1 Score: 327.02 bits (837), Expect = 1.112e-104
Identity = 210/534 (39.33%), Postives = 286/534 (53.56%), Query Frame = 3
Query:   75 CICNYAHCF-EKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  E  C+    CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL   L                     ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGK +IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQ-QCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACIL--------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911])

HSP 1 Score: 327.02 bits (837), Expect = 1.112e-104
Identity = 210/534 (39.33%), Postives = 286/534 (53.56%), Query Frame = 3
Query:   75 CICNYAHCF-EKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  E  C+    CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL   L                     ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGK +IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQ-QCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACIL--------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. Ensembl Mouse
Match: Acvrl1 (activin A receptor, type II-like 1 [Source:MGI Symbol;Acc:MGI:1338946])

HSP 1 Score: 304.294 bits (778), Expect = 5.406e-96
Identity = 157/331 (47.43%), Postives = 211/331 (63.75%), Query Frame = 3
Query:  660 CTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD--SKSVFVLELNAMIRESWSEKSQTR 1646
            CT+GSGSG+PFLVQRT+ARQV L+  +GKGR+GEVW+G+++GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYD+L    +     + L  S A GL+HLH EI  G QGKP+IAHRDLKS+N+L+    + CIADLGL+V+ S ++      + +  ++GT+RYMAPE+L + +  D                             FE +   DI+AF LV+WE+  RT ++G   + +Y+ P+ D+VP DPS  +M+++VCVD+  P +P+  +    +  L  M+RE W      R
Sbjct:  181 CTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIF-GTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYL--DIGNNPRVGTKRYMAPEVLDEHIRTDC----------------------------FESYKWTDIWAFGLVLWEIARRTIING--IVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 478          
BLAST of activin receptor-1 vs. UniProt/SwissProt
Match: sp|Q28041|ACVR1_BOVIN (Activin receptor type-1 OS=Bos taurus OX=9913 GN=ACVR1 PE=2 SV=1)

HSP 1 Score: 331.643 bits (849), Expect = 1.304e-105
Identity = 210/533 (39.40%), Postives = 288/533 (54.03%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C ++       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGDEAHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. UniProt/SwissProt
Match: sp|Q04771|ACVR1_HUMAN (Activin receptor type-1 OS=Homo sapiens OX=9606 GN=ACVR1 PE=1 SV=1)

HSP 1 Score: 330.872 bits (847), Expect = 2.788e-105
Identity = 210/533 (39.40%), Postives = 287/533 (53.85%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  +       CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL  CL+                    ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQQCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLA-CLL-------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. UniProt/SwissProt
Match: sp|P80201|ACVR1_RAT (Activin receptor type-1 OS=Rattus norvegicus OX=10116 GN=Acvr1 PE=2 SV=1)

HSP 1 Score: 327.02 bits (837), Expect = 7.613e-104
Identity = 209/534 (39.14%), Postives = 287/534 (53.75%), Query Frame = 3
Query:   75 CICNYAHCF-EKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  E  C+    CF  +S+  ND  ++Y   C +        C+   S    V+CC  + CN+N T      P +  +F  +  + L +  +I   V A+ L    L                     ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGK +IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQ-QCFSSLSV--NDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTAR---LPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACIL--------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. UniProt/SwissProt
Match: sp|P37172|ACVR1_MOUSE (Activin receptor type-1 OS=Mus musculus OX=10090 GN=Acvr1 PE=2 SV=2)

HSP 1 Score: 327.02 bits (837), Expect = 7.778e-104
Identity = 210/534 (39.33%), Postives = 286/534 (53.56%), Query Frame = 3
Query:   75 CICNYAHCF-EKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVE--NYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIE-NCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C  E  C+    CF  +S+  ND   +Y   C +        C+   S    V+CC  + CN+N T      P +  +F     + L +  +I   V A+ LL   L                     ++   + R+   NQ    P                R VE     GL+  N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G++ GE VAVKIFSSRDE SW RET +YN+ +LRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGK +IAHRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L        D TI+ +C                     F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   35 CVCEGLSCGNEDHCEGQ-QCFSSLSI--NDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQ---LPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACIL--------------------GVALRKFKRR---NQERLNP----------------RDVEYGTIEGLITTNVGDSTL---AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVL--------DETIQVDC---------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 485          
BLAST of activin receptor-1 vs. UniProt/SwissProt
Match: sp|Q90ZK6|ACVR1_CHICK (Activin receptor type-1 OS=Gallus gallus OX=9031 GN=ACVR1 PE=2 SV=1)

HSP 1 Score: 325.865 bits (834), Expect = 1.856e-103
Identity = 167/333 (50.15%), Postives = 218/333 (65.47%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQS-STNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET +YN+ LLRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  T +    C+ ++ S A+GL+HLH EI  G QGKP+I+HRDLKSKNIL+ K G+ CIADLGL+V+ S STN L    V +  ++GT+RYMAPE+L + +  D                             F+ +   DI+AF LV+WEV  R   +G   + +YK P+ D+VP DPS  +MR++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:  182 SCTSGSGSGLPFLVQRTVARQITLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF-GTQGKPAISHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL---DVGNNPRVGTKRYMAPEVLDETIQADC----------------------------FDSYKRVDIWAFGLVLWEVARRMVSNG--IVEDYKPPFYDLVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR 480          
BLAST of activin receptor-1 vs. TrEMBL
Match: I1ZI74 (Receptor protein serine/threonine kinase (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 1107.05 bits (2862), Expect = 0.000e+0
Identity = 545/546 (99.82%), Postives = 546/546 (100.00%), Query Frame = 3
Query:   69 ISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPXXXXXXXXXXXXXXTENLC 1706
            ISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYN+YLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPSALRLKKNLKSLLSTENLC
Sbjct:    1 ISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNTYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPSALRLKKNLKSLLSTENLC 546          
BLAST of activin receptor-1 vs. TrEMBL
Match: A0A2U9CBJ4 (Receptor protein serine/threonine kinase OS=Scophthalmus maximus OX=52904 GN=SMAX5B_018686 PE=3 SV=1)

HSP 1 Score: 352.829 bits (904), Expect = 2.692e-109
Identity = 212/541 (39.19%), Postives = 295/541 (54.53%), Query Frame = 3
Query:   45 IKAF*EMQISCICNYAHCFE-KKCKTYFGCFKLISLYGNDTGKIYL-DCLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            +KA    +  C+C  + C    +CK +  CF  +++ G     +Y   C K     +  C+   S   +V+CC  +LCN NST    IK N++ N+      +L+I  V P  +  ++L  + +++F + HHN                         Q E +P + D E                 GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITH+H +GSLYDYL  + +  + C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D                             FE +   DI+A  LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  +  +++E W +    R
Sbjct:  196 VKALIRQEHECVCEGSSCVTGNRCKGH-QCFSSLTVSGGSL--VYQKGCFKVYEQSTMTCKTPPSRDQIVECCQGSLCNMNSTVELPIKANELPNYS---VTTLAIVIVAPI-IVLIVLSAVAILVFRRIHHN-------------------------QME-RPTSRDAEYG------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASGCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQMDC----------------------------FESYKRVDIWALGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSAR 654          
BLAST of activin receptor-1 vs. TrEMBL
Match: A0A3B3ZSP8 (Receptor protein serine/threonine kinase OS=Periophthalmus magnuspinnatus OX=409849 PE=3 SV=1)

HSP 1 Score: 345.51 bits (885), Expect = 1.204e-108
Identity = 211/531 (39.74%), Postives = 287/531 (54.05%), Query Frame = 3
Query:   75 CICNYAHCFE-KKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C  + C    +C+ +  CF   SL  N    +Y   C K     +  C+   S   +V+CC  +LCN NST    +K  ++S++      +L+I  V P  +  +IL  I +++F + HHN                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  + +    C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D                             FE F   DI+A  LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  L  +++E W +    R
Sbjct:   31 CVCEGSSCETLNRCRGH-QCFS--SLTVNTGSLVYQKGCFKVYEQSTLTCKTPPSRDQVVECCYGHLCNMNSTVQLPVKAEELSHYS---VTTLAIVIVAPI-IVLIILSTIAILIFRRIHHN-----------------QMERLTSRDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLSTLDALSCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQMDC----------------------------FESFKRVDIWALGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLSSLAKLMKECWYQNPSAR 479          
BLAST of activin receptor-1 vs. TrEMBL
Match: A0A3Q1AWG0 (Receptor protein serine/threonine kinase OS=Amphiprion ocellaris OX=80972 PE=3 SV=1)

HSP 1 Score: 345.51 bits (885), Expect = 1.309e-108
Identity = 206/530 (38.87%), Postives = 285/530 (53.77%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C  + C          CF   SL  N    +Y   C K     +  C+   S   +V+CC  +LCN NST    +K +++S++      +L+I  V P  +  +IL  + +++F + HHN                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITH+H +GSLYDYL  + +  + C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D                             FE +   DI+A  LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  +  +++E W +    R
Sbjct:   27 CVCEGSSCVTGNRCMGHQCFT--SLTVNAGSLMYQKGCFKAYEQSTLTCKTPPSRDQIVECCHGHLCNMNSTVELPVKADELSSYS---VTTLAIVIVAPI-IVLIILSAVAILVFRRIHHN-----------------QMERLTSRDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQMDC----------------------------FESYKRVDIWALGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSAR 475          
BLAST of activin receptor-1 vs. TrEMBL
Match: A0A3P8THC0 (Receptor protein serine/threonine kinase OS=Amphiprion percula OX=161767 PE=3 SV=1)

HSP 1 Score: 345.51 bits (885), Expect = 1.823e-108
Identity = 206/530 (38.87%), Postives = 285/530 (53.77%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C  + C          CF   SL  N    +Y   C K     +  C+   S   +V+CC  +LCN NST    +K +++S++      +L+I  V P  +  +IL  + +++F + HHN                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITH+H +GSLYDYL  + +  + C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D                             FE +   DI+A  LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VCVD+ RP +P+       +  +  +++E W +    R
Sbjct:   38 CVCEGSSCVTGNRCMGHQCFT--SLTVNAGSLMYQKGCFKAYEQSTLTCKTPPSRDQIVECCHGHLCNMNSTVELPVKADELSSYS---VTTLAIVIVAPI-IVLIILSAVAILVFRRIHHN-----------------QMERLTSRDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQMDC----------------------------FESYKRVDIWALGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSAR 486          
BLAST of activin receptor-1 vs. Ensembl Cavefish
Match: ACVR1 (activin receptor type-1 [Source:NCBI gene;Acc:103030586])

HSP 1 Score: 325.865 bits (834), Expect = 1.478e-104
Identity = 203/532 (38.16%), Postives = 276/532 (51.88%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILL-VICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD---SKSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C   +      CF  ++L  +D   +Y   C          C+   S   +V+CC  +LCN N +                +Y   ++  VI   V  +I L    +++F + HHN                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  + +    C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D                             FE +   DI+AF LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VC+D+ RP +P+   S S     +  +++E W +    R
Sbjct:   25 CVCEGRSCVSGERCMGQQCFSSLTL--SDGVLVYQKGCFTVYEQGRMTCKTPPSPDQIVECCQAHLCNMNLSVA----------LPGPNYSVTTLAIVIVAPVIVLIFLSTAAILVFRRIHHN-----------------QMERLTARDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLSTLDAPSCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVNKNGQCCIADLGLAVMHYQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQVDC----------------------------FESYKRVDIWAFGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCIDQQRPNIPNRWFSDSTLT-SIAKLMKECWYQNPSAR 468          
BLAST of activin receptor-1 vs. Ensembl Cavefish
Match: ACVR1 (activin receptor type-1 [Source:NCBI gene;Acc:103030586])

HSP 1 Score: 330.102 bits (845), Expect = 4.919e-104
Identity = 201/530 (37.92%), Postives = 279/530 (52.64%), Query Frame = 3
Query:   75 CICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C    C   +      CF  ++L  +D   +Y   C          C+   S   +V+CC  +LCN N +    ++  +  N+      +L+I  V P  +  + L    +++F + HHN                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH +GSLYDYL  + +    C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D                             FE +   DI+AF LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VC+D+ RP +P+       +  +  +++E W +    R
Sbjct:  207 CVCEGRSCVSGERCMGQQCFSSLTL--SDGVLVYQKGCFTVYEQGRMTCKTPPSPDQIVECCQAHLCNMNLSVALPVRVVEGPNYS---VTTLAIVIVAPV-IVLIFLSTAAILVFRRIHHN-----------------QMERLTARDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLSTLDAPSCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVNKNGQCCIADLGLAVMHYQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQVDC----------------------------FESYKRVDIWAFGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCIDQQRPNIPNRWFSDSTLTSIAKLMKECWYQNPSAR 655          
BLAST of activin receptor-1 vs. Ensembl Cavefish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9])

HSP 1 Score: 313.153 bits (801), Expect = 4.763e-100
Identity = 164/332 (49.40%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYDYL    +     + +  S A+GL HLHTEI  G +GKP+IAHRDLKSKNIL+ K    CIADLGL+V  S  +      V +  K+GT+RYMAPE+L + +  D                             F+ +   DI+AF LV+WE+  RT+ +G   + EYK P+ D+VP DPS  EMR++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:  147 SCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVDMAHGLQMAASVASGLVHLHTEIF-GTEGKPAIAHRDLKSKNILVKKDLRCCIADLGLAVTHSQADNQL--NVGNNPKVGTKRYMAPEVLDESIQTDC----------------------------FDAYKRVDIWAFGLVLWEIARRTYSNG--IVEEYKPPFYDLVPNDPSFEEMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSAR 445          
BLAST of activin receptor-1 vs. Ensembl Cavefish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9])

HSP 1 Score: 312.768 bits (800), Expect = 3.058e-99
Identity = 164/332 (49.40%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYDYL    +     + +  S A+GL HLHTEI  G +GKP+IAHRDLKSKNIL+ K    CIADLGL+V  S  +      V +  K+GT+RYMAPE+L + +  D                             F+ +   DI+AF LV+WE+  RT+ +G   + EYK P+ D+VP DPS  EMR++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:  191 SCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVDMAHGLQMAASVASGLVHLHTEIF-GTEGKPAIAHRDLKSKNILVKKDLRCCIADLGLAVTHSQADNQL--NVGNNPKVGTKRYMAPEVLDESIQTDC----------------------------FDAYKRVDIWAFGLVLWEIARRTYSNG--IVEEYKPPFYDLVPNDPSFEEMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSAR 489          
BLAST of activin receptor-1 vs. Ensembl Cavefish
Match: acvrl1 (activin receptor type-1-like [Source:NCBI gene;Acc:103041954])

HSP 1 Score: 311.997 bits (798), Expect = 3.815e-99
Identity = 152/301 (50.50%), Postives = 205/301 (68.11%), Query Frame = 3
Query:  660 CTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRP 1562
            CTSGSG+G+P+LVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+  LRH NILG+ ASDM S+   TQLWL+TH+H LGSLYD+L  + +    C+ +  S A+GL HLHTEI+S  QGKP+IAHRDLKS+NIL+ + G+ CIADLGL+V+ S +N      V +  ++GT+RYMAPE+L + +  D                             FE +   DI+A  LV+WE+  RT ++G   + EY++P+ D+VP DPS  EM+++VCVD++RP
Sbjct:  169 CTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSVASGLVHLHTEILS-TQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSNDYL--DVGTNPRVGTKRYMAPEVLDESIRVDV----------------------------FESYKQTDIWALGLVLWEITRRTIVNG--IVEEYRLPFFDVVPSDPSFEEMKKVVCVDQYRP 436          
BLAST of activin receptor-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005861.1 (pep scaffold:Pmarinus_7.0:GL476493:320276:325221:1 gene:ENSPMAG00000005274.1 transcript:ENSPMAT00000005861.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 313.923 bits (803), Expect = 6.340e-103
Identity = 164/332 (49.40%), Postives = 208/332 (62.65%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ+ LI  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYD+L    +  + C+ L  S AAGLSHLH EI  G  GKP+IAHRDLKSKNIL+   G+ CIADLGL+V+ S         +    ++GT R+MAPE+L + L  D                             F+ +  ADI+A  LV+WE+  RT  +G     EY+VP+ D VP DPS  EM+++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:    6 SCTSGSGSGLPFLVQRTVARQITLIECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWCRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHECGSLYDWLQRWPLEASSCLRLALSVAAGLSHLHGEIF-GTHGKPAIAHRDLKSKNILVKGNGQCCIADLGLAVMHSQE--WSRLDIGQNPRVGTVRFMAPEVLDETLQTDC----------------------------FDAYKRADIWALGLVLWEIARRTLSNG--IAEEYRVPFHDAVPSDPSFDEMKKVVCVEQQRPNIPNRWFSDPSLTALAKLMKECWYQNPSAR 304          
BLAST of activin receptor-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006990.1 (pep scaffold:Pmarinus_7.0:GL476821:19527:36497:1 gene:ENSPMAG00000006293.1 transcript:ENSPMAT00000006990.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 311.997 bits (798), Expect = 3.623e-100
Identity = 208/530 (39.25%), Postives = 288/530 (54.34%), Query Frame = 3
Query:   75 CICNYAHCFE-KKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSS-TNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C C    C +  +C  +  CF  ++L  +    +   C + ++     C+   S++  ++CC  +LCN NST     KP    + +      L++  V PF +   +  V+ L++    H  L R +K                        P  DD + + +++            L+P N  ++     + L   SCTSGSGSG+PFLVQRT+ARQ+ L++ +GKGRFGEVW+G + GE VAVKIFSSRDE SW RET IYN+  LRH NILG+ ASDM SR   TQLWL+TH+H  GSLYD+LH+  +    C+ L  S AAGL+HLH EI+ G QGKP IAHRD+KSKNIL+   G+ CIADLGL+V+ S  TN L    +    ++GT+RYMAPE+L D +  D                             F+ F  AD++AF LV+WE+  RT  +G     EYKVP+ DIVP DPS  EMR+LVCVD+ RP +P+       +  L  +++E W +    R
Sbjct:    3 CACEGMSCDDLDRCHGHH-CFTSVNLE-DGVPVLQKGCFRANVQGKLTCRTPPSSEQAIECCRGHLCNFNSTVALEPKPKPTEDPNAPGLQRLALLIVGPFLLLLGLSGVVILVI----HRILWRRIKHL----------------------PSIDDEKGNAADA------------LIPTNVGDSTL---ADLFDHSCTSGSGSGLPFLVQRTVARQITLVDCVGKGRFGEVWRGHWQGENVAVKIFSSRDEHSWVRETEIYNTVSLRHENILGFIASDMTSRNSSTQLWLVTHFHETGSLYDHLHAATLDAAACLRLALSAAAGLAHLHVEIV-GTQGKPGIAHRDIKSKNILVKDNGQCCIADLGLAVMHSQMTNML---DLGQNPRVGTKRYMAPELLDDSIQADC----------------------------FDSFKRADVWAFGLVLWEIARRTVNNG--IAEEYKVPFHDIVPCDPSFDEMRKLVCVDQQRPTIPNRWFSDPMLAALARVMKECWYQNPSAR 455          
BLAST of activin receptor-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005886.1 (pep scaffold:Pmarinus_7.0:GL476493:320297:325703:1 gene:ENSPMAG00000005274.1 transcript:ENSPMAT00000005886.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 305.064 bits (780), Expect = 1.670e-99
Identity = 161/332 (48.49%), Postives = 205/332 (61.75%), Query Frame = 3
Query:  663 TSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTF--LSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            TSGSGSG+PFLVQRT+ARQ+ LI  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITHYH  GSLYD+L    +  + C+ L  S AAGLSHLH EI  G  GKP+IAHRDLKSKNIL+   G+ CIADLGL+V+ S         +    ++GT R+MAPE+L + L  D                             F+ +  ADI+A  LV+WE+  RT   +       EY+VP+ D VP DPS  EM+++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:    1 TSGSGSGLPFLVQRTVARQITLIECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWCRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHECGSLYDWLQRWPLEASSCLRLALSVAAGLSHLHGEIF-GTHGKPAIAHRDLKSKNILVKGNGQCCIADLGLAVMHSQE--WSRLDIGQNPRVGTVRFMAPEVLDETLQTDC----------------------------FDAYKRADIWALGLVLWEIARRTLSNVLSLGIAEEYRVPFHDAVPSDPSFDEMKKVVCVEQQRPNIPNRWFSDPSLTALAKLMKECWYQNPSAR 301          
BLAST of activin receptor-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006012.1 (pep scaffold:Pmarinus_7.0:GL476493:425401:440684:1 gene:ENSPMAG00000005387.1 transcript:ENSPMAT00000006012.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 283.878 bits (725), Expect = 5.448e-89
Identity = 156/336 (46.43%), Postives = 210/336 (62.50%), Query Frame = 3
Query:  654 DSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD----SKSVFVLELNAMIRESWSEKSQTR 1646
            D+ T+GSGSG+P LVQRTIAR + L + IGKGRFGEVW+G + GE VAVKIFSSR+E SW RE  IY + +LRH NILG+ A+D       TQLWL++ YH LGSL+DYL+   +S  E V    S A+GL+HLH +I+ G QGKP+IAHRD+KSKNIL+ +    CIADLGL+V   S+T+ +  +P N   ++GT+RYMAPE+L D        TI                +H      F+ F   DIYAF LV+WE+  R  + G     +Y++PY D+V  DPS  +MR++VC    RP +P+    S+S+ V  +  ++RE W   +  R
Sbjct:  186 DNTTTGSGSGLPLLVQRTIARTIMLQDSIGKGRFGEVWRGRWRGEDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHELGSLFDYLNRFSLSVEELVKFSLSVASGLAHLHMDIV-GTQGKPAIAHRDIKSKNILVKRNRTCCIADLGLAVRHDSTTDSIDIAPNN---RVGTKRYMAPEVLDD--------TIN--------------MKH------FDSFKRGDIYAFGLVLWEISRRCVVGG--ITEDYQLPYHDMVSPDPSVDDMRRVVCEQSLRPNVPNRWQSSESLRV--MGRVMRECWYANASAR 485          
BLAST of activin receptor-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003828.1 (pep scaffold:Pmarinus_7.0:GL476610:23057:33770:1 gene:ENSPMAG00000003465.1 transcript:ENSPMAT00000003828.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 281.567 bits (719), Expect = 3.902e-88
Identity = 157/331 (47.43%), Postives = 202/331 (61.03%), Query Frame = 3
Query:  663 TSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS-KSVFVLELNAMI-RESWSEKSQTR 1646
            TSGSGSG+P LVQRTIAR V L   IGKGRFGEVW+G + GE VAVKIFSSR+E SW RE  IY + +LRH NILG+ A+D       TQLWL++ YH  GSL+DYL+   ++      +  S A+GL+HLH EI+ G QGKP+IAHRDLKSKNIL+ K G   IADLGL+V   S+T+ +  +P N   ++GT+RYMAPE+L D +                        +H      F+ F  AD+YA  LV WE+  R    G   + EY++PY D+VP DPS  EMR++VC  K RP +P    S  +L + A I +E W   +  R
Sbjct:  193 TSGSGSGLPLLVQRTIARTVALQESIGKGRFGEVWRGKWRGEDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTEEGMARMALSIASGLAHLHMEIV-GTQGKPAIAHRDLKSKNILVKKNGTCAIADLGLAVRHDSATDTIDIAPNN---RVGTKRYMAPEVLDDTIN----------------------LKH------FDSFKRADMYALGLVYWEIARRCTQGG--VLDEYQLPYYDVVPSDPSVEEMRRVVCDQKLRPSIPTRWHSCKMLHIVAKIMQECWYHNAAAR 489          
BLAST of activin receptor-1 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 63.929 bits (154), Expect = 4.554e-11
Identity = 52/184 (28.26%), Postives = 85/184 (46.20%), Query Frame = 3
Query:  738 IGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLL----RHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHK--IGTRRYMAPEILA 1271
            IG+G  G V+     G  V+V I     E    +E  I N  L+    +HPNI+ +  S ++       LW+I  Y   GSL D +   +++  +  ++   T +GL  LH++          + HRD+KS NIL+   G+  + D G         C   + +N K    +GT  +MAPE+++
Sbjct:  626 IGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKEL-IINEILVMKGSKHPNIVNFIDSYVLK----GDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSK---------GVLHRDIKSDNILLSMEGDIKLTDFGF--------CAQINELNLKRTTMVGTPYWMAPEVVS 787          
BLAST of activin receptor-1 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 63.929 bits (154), Expect = 4.774e-11
Identity = 60/200 (30.00%), Postives = 92/200 (46.00%), Query Frame = 3
Query:  696 VQRTIARQVQ--LINGIGKGRFGEVWKG--AYYGEMVAVK-IFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLH--STVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILAD 1274
            +QR   + VQ  L   IG+G +G V+K    +  ++VA+K +    DE        I     L H NI+ Y+     S     +L+++  Y A GSL   +   ST +S NE  + +  T  GL +LH E          + HRD+K+ NIL+       +AD G+S + +S+              GT  +MAPEIL +
Sbjct:   15 IQRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSY----ELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGE---------GVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLA---------GTLNWMAPEILGN 192          
BLAST of activin receptor-1 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 63.5438 bits (153), Expect = 6.222e-11
Identity = 53/194 (27.32%), Postives = 86/194 (44.33%), Query Frame = 3
Query:  738 IGKGRFGEVWKG--AYYGEMVAVKIF---SSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTI 1304
            IG+G+FG V+KG     G + A+K+    S  DE    +    + + L +  NI  YY S +      T LW+I  + A GSL   L    I       ++      L  +H         K ++ HRD+K+ N+LI   G   + D G++   + T+      +  +   GT  +MAPE++ + +  DT   I
Sbjct:   29 IGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKD----TSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIH---------KDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTS------LRRQTMAGTPYWMAPEVIMEGVYYDTKVDI 203          
BLAST of activin receptor-1 vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885])

HSP 1 Score: 63.1586 bits (152), Expect = 7.639e-11
Identity = 56/205 (27.32%), Postives = 96/205 (46.83%), Query Frame = 3
Query:  723 QLINGIGKGRFGEVWKGAYY---GEMVAVKIFS----SRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYL-HSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENC 1313
            Q++  +G+G FG+V K AY+   G+ VA+KI +    ++ +     E  I    LLRHP+I+  Y  D++      ++ ++  Y A   L+DY+     +S  E         + + + H         +  I HRDLK +N+L+ +     IAD GLS + +  N L       K   G+  Y APE+++  L    +  + +C
Sbjct:   56 QIVKTLGEGSFGKV-KLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLY--DVIK--SKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH---------RHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFL-------KTSCGSPNYAAPEVISGKLYAGPEVDVWSC 238          
BLAST of activin receptor-1 vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 61.2326 bits (147), Expect = 2.473e-10
Identity = 52/184 (28.26%), Postives = 83/184 (45.11%), Query Frame = 3
Query:  738 IGKGRFGEVWKGA--YYGEMVAVKI--FSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISF--NECVS-LLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEIL 1268
            IG+G FG+V+K       E+VA+K+      DE        I+    L+ P I  Y A+ +        +W++  Y   GS  D L  + ++    E VS ++H    GL +LH +            HRD+K+ NIL+ + G   + D G+S    ST       +     +GT  +MAPE++
Sbjct:   24 IGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLED----VSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQ---------RKIHRDIKAANILLNEEGMVKLGDFGVSGHIRST-------LKRDTFVGTPYWMAPEVV 187          
BLAST of activin receptor-1 vs. Ensembl Nematostella
Match: EDO49083 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI35])

HSP 1 Score: 299.671 bits (766), Expect = 3.779e-94
Identity = 193/536 (36.01%), Postives = 272/536 (50.75%), Query Frame = 3
Query:   75 CICN--YAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSL----VKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCD--SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQ--GKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD--SKSVFVLELNAMIRESWSEKSQTR 1646
            CIC+   ++  E+ C T  GCF  + L  N    +   CLK++ H + +C+           +CC  +LCNK+   N    P+ I    +     L ++F+I    A +  L++CLI+             +Y  F                          R L   + H + V  +  L P++  +   N +  L  D    +SGSGSG+P LVQRT+AR+ QLI  IGKGR+GEVWKG Y GE VA+KIFS+ DE SW RET IYN+ +LRH NILG+ A+D+ SR   T +WLI HYH  GSLYD+L+ +         L  S A+GL+HLHTEI    +   KP+IAHRD+KSKNIL+       + DLGL+V+ S          N K  +GTRRYMAPEIL +                         T +  C      F  AD+YAF LV+WE+  R ++SG   + EY+ P+ D+V  DPS  EM+++V  +  RP LP+  +    +  ++ +IRE W+     R
Sbjct:   39 CICSDCRSNAGEQTCSTETGCFSSLFLLENGQSSVTKGCLKDADHYNMMCRGPRGKPNLHDTRCCTHDLCNKH--INPTHAPSTIPPIKQE---KLDVQFLIISICAPVAALIVCLII-------------VYMIF--------------------------RHLMKHHAHHQSVPRHD-LGPVSHVQCPCNEERPLIQDLIDISSGSGSGLPLLVQRTVARETQLIESIGKGRYGEVWKGVYQGESVAIKIFSTTDEASWKRETEIYNTVMLRHDNILGFIAADVHSRKSTTYMWLIMHYHEQGSLYDFLNRSTFDAETLCRLALSAASGLAHLHTEIFGTNRTGSKPAIAHRDIKSKNILVKSNYTCAVGDLGLAVMYSQDKDSVDMGENPKIAVGTRRYMAPEILEE-------------------------TINAKC---INSFKRADVYAFGLVLWEI-ARRYVSG-GIVEEYQPPFYDMVQSDPSIDEMKKVVVTENKRPSLPNRWTGDPTLQVMSKLIRECWNPNPAAR 499          
BLAST of activin receptor-1 vs. Ensembl Nematostella
Match: EDO30434 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0S6])

HSP 1 Score: 269.24 bits (687), Expect = 2.179e-83
Identity = 187/541 (34.57%), Postives = 259/541 (47.87%), Query Frame = 3
Query:   66 QISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLD--CLKESIHDSYICQ-----NSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCT-----SGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            QI+C C+Y       C T   C  ++    + TG++     C      D  +C+          L  CC +N+CN ++   N   P++ S          S   V+   V+   +LVICL   +               +   + N  RQ   N     P                              EE       SL CD  T     +GSGSG+P LVQRT+ARQ+  I  IG GR+G+V++G + GE VAVKIFSSR+E SW RE  IY + +LRH NILG+ A+D       TQLWLIT YHA GSLYDYL    +     + L  S A+GL+HLH EII G QGKP+IAHRDLKS+NIL+   G  CIADLGL+V  +S       P    +++GTRRYMAPE L D         + N                      F  +   DIYAF LV+WE+  R   S +    +Y++PY D + +DPS  E+ ++VC++K+RP  P+   +   ++ +  +++E W    + R
Sbjct:    6 QITCKCDYCQETNSTCVTKGACLTILQ-RDSSTGEVKRGHACTYNPPADRLVCEPGYSTERPHQLYHCCYYNMCNVDT---NVTLPSKTSGRSGRP----STAEVVAMIVSP--VLVICLATVSII-------------YCYQKRNPQRQCILNDGSESP------------------------------EEVLIPAGKSL-CDLITNADISTGSGSGLPLLVQRTVARQITPIELIGSGRYGDVYRGQWRGEDVAVKIFSSREECSWFREAQIYQTVMLRHENILGFIAADNKDNGAWTQLWLITDYHANGSLYDYLQRVTLDMKSMLKLTISIASGLAHLHMEII-GTQGKPAIAHRDLKSRNILVKDNGTCCIADLGLAVCHNSEQDTLDIPYG--NRVGTRRYMAPEFLED------SNQVRN----------------------FCAYKHGDIYAFGLVLWEITRRCICSDK--CEDYQLPYFDKICVDPSIEEVWKVVCLEKYRPSHPNYWLQDQVMMRVAKLMQECWHHSPEAR 459          
BLAST of activin receptor-1 vs. Ensembl Nematostella
Match: EDO41833 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S365])

HSP 1 Score: 258.455 bits (659), Expect = 6.517e-79
Identity = 140/340 (41.18%), Postives = 196/340 (57.65%), Query Frame = 3
Query:  663 TSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSV----------LQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            +S SGSG+P LVQRTIA+QV L+  +GKGR+GEVWK  ++GE VAVKIF S  E SW RET IY + LLRH +ILG+ ASD++     TQ++LI  YH LGSLYD+L    ++      L  S AAG++HLH EI+ G QGKP IAHRD+KSKNIL+ +    CIAD GL+V          L   TN           ++GT+RYM+PE+L+  + P++                            F  +  AD+Y+FALV+WE+  R          EY+VPY D V  DP+  EM+++V +++ RP +P+   +   +  +  ++ E WS++   R
Sbjct:  191 SSASGSGLPLLVQRTIAKQVTLVQSVGKGRYGEVWKARWHGEDVAVKIFLSHCEKSWMRETEIYQTVLLRHESILGFIASDIIGSGQVTQMYLIMDYHPLGSLYDFLRGHQLNKKITGKLAFSAAAGIAHLHAEIL-GTQGKPMIAHRDIKSKNILVKENLTCCIADFGLAVKYIPETKGIDLNKDTN-----------RVGTKRYMSPEVLSQTIDPES----------------------------FSAYKMADMYSFALVLWEISRRCISDETGLCEEYEVPYFDAVSNDPTFEEMKRVVVLERRRPNIPNRWFRDEMLRTMGKLMAECWSQQPAAR 490          
BLAST of activin receptor-1 vs. Ensembl Nematostella
Match: EDO49370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG69])

HSP 1 Score: 162.54 bits (410), Expect = 8.795e-44
Identity = 110/353 (31.16%), Postives = 172/353 (48.73%), Query Frame = 3
Query:  627 YNRQSSLHCDSCTSGSGSGMPFL---VQRTIARQVQLINGIGKGRFG-EVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDM--VSRFGC---TQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEI--ISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKS--VFVLELNAMIRESWSEKSQTR 1646
            YN Q  +   SC +     +      +Q    R +QL+  + +G+FG  VWK  Y    VAVKIF  ++ T+W  E   Y    L H N+L +   ++   S++     T+ WLIT +H  GSL D+L    +   E + L  S   GL++LH+++  I+    KP IAHRD+KSKNIL+      CI+D GL++    ++ L      +  ++GT+RYMAPE+L   +     FT E+                         F+  D+YA  LV+WE+L+R F      + +Y++P++  V L PS  +M+Q+V   K RP+  DS      +  +   I E W +  + R
Sbjct:  110 YNHQKGISSRSCNAEESEPINITTTPLQDVNRRPIQLLEVVSQGQFGVTVWKAKYSINTVAVKIFPHQEFTAWVNERDFYKLCGLDHENVLTFIGDEVHHESQYNGQIYTEYWLITDFHENGSLSDFLKQRSLDLAELLQLASSVCDGLAYLHSDVPAINNSSHKPCIAHRDVKSKNILVKSDLTCCISDFGLALKFDQSDKLG----ETHGQVGTKRYMAPEVLEGAI----SFTRES-------------------------FLRIDMYACGLVLWELLSR-FSVHDDPVEDYRLPFEQEVGLHPSLEDMQQVVVQKKMRPQFKDSWRCHAALRVIIQTIEECWDQDGEAR 428          
BLAST of activin receptor-1 vs. Ensembl Nematostella
Match: EDO41379 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4E9])

HSP 1 Score: 130.183 bits (326), Expect = 5.615e-33
Identity = 93/316 (29.43%), Postives = 141/316 (44.62%), Query Frame = 3
Query:  717 QVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSK---HKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS---KSVFVLELNAMIRESWSEKSQTR 1646
            Q+ L   IG+GR+G VWKG  + E++AVK+F +     W  E  ++ S L  HP+IL ++A+         +  L++ YH  GSL +YL    + + E   +  S +AGL+ LH +       KPS AHRD+ SKNIL+   G   +AD G ++  S        P +      ++GT RYMAPE+L   +       I+  L                           D+YA +LV+WEV  R      K +  YK P++  +    ++  M   V   K RP  PD+       +  L   I + W +    R
Sbjct:   96 QLTLGQLIGQGRYGTVWKGTMFNEVMAVKVFGAEHRLFWQAEKDLF-SALDHHPSILRFFAACERETNSSPEYLLLSEYHPRGSLQNYLRQHSVCWREMCIMGSSMSAGLAFLHQD-----ANKPSFAHRDINSKNILVKVDGSCVLADFGFAMNVSDAT----KPADDGTLITEVGTLRYMAPEVLDGAV---NLHDIQGALK------------------------QIDVYAMSLVIWEVSMRCEDIFGKQVPPYKAPFEAELGPMITSEHMHTYVVQKKLRPGFPDAWKRNHSGLRFLKETIEDCWDQDGDAR 374          
BLAST of activin receptor-1 vs. Ensembl Medaka
Match: ENSORLT00000020918.2 (activin A receptor type 1 [Source:NCBI gene;Acc:101173900])

HSP 1 Score: 330.102 bits (845), Expect = 4.620e-106
Identity = 203/535 (37.94%), Postives = 284/535 (53.08%), Query Frame = 3
Query:   75 CICNYAHCFE-KKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLV----ICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C  + C    +C+ +  CF   SL  +    +Y   C K     +  C+   S   +V+CC  +LCN N T     K + +S +        S+  ++   VA +I L+    + + +F + H N                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITH+H +GSLYDYL  + +    C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D+                            FE +   DI+A  LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VCVD+ RP +P+     + +  +  +++E W +    R
Sbjct:   29 CVCEGSSCVTGNRCRGH-QCFS--SLTDSAGTTVYQKGCFKVYEQSTLTCKTPPSRDQIVECCQGHLCNMNITVQLPPKDHVLSAY--------SVTTLVTVIVAPIIALIFFSALAVFVFRRIHRN-----------------QMERLTPRDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDAPGCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQMDS----------------------------FESYKRVDIWALGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDLTLTSMAKLMKECWYQNPSAR 477          
BLAST of activin receptor-1 vs. Ensembl Medaka
Match: ENSORLT00000020917.2 (activin A receptor type 1 [Source:NCBI gene;Acc:101173900])

HSP 1 Score: 327.405 bits (838), Expect = 6.551e-103
Identity = 203/535 (37.94%), Postives = 284/535 (53.08%), Query Frame = 3
Query:   75 CICNYAHCFE-KKCKTYFGCFKLISLYGNDTGKIYLD-CLKESIHDSYICQN--STKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLV----ICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQ-SSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            C+C  + C    +C+ +  CF   SL  +    +Y   C K     +  C+   S   +V+CC  +LCN N T     K + +S +        S+  ++   VA +I L+    + + +F + H N                    +L+    E+                         GL+  N  E+     + L   SCTSGSGSG+PFLVQRT+ARQ+ L   +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+ LLRH NILG+ ASDM SR   TQLWLITH+H +GSLYDYL  + +    C+ +  S A+GL+HLH EI  G QGKP+IAHRDLKSKNIL+ K G+ CIADLGL+V+    TN L    V +  K+GT+RYMAPE+L D +  D+                            FE +   DI+A  LV+WE+  RT  +G   + +YK P+ D+VP DPS  +M+++VCVD+ RP +P+     + +  +  +++E W +    R
Sbjct:  209 CVCEGSSCVTGNRCRGH-QCFS--SLTDSAGTTVYQKGCFKVYEQSTLTCKTPPSRDQIVECCQGHLCNMNITVQLPPKDHVLSAY--------SVTTLVTVIVAPIIALIFFSALAVFVFRRIHRN-----------------QMERLTPRDAEYG---------------------TIDGLIASNVGESTL---ADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDAPGCLRMALSIASGLAHLHVEIF-GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNEL---DVGNNPKVGTKRYMAPEVLDDSIQMDS----------------------------FESYKRVDIWALGLVLWEIARRTVSNG--IVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDLTLTSMAKLMKECWYQNPSAR 657          
BLAST of activin receptor-1 vs. Ensembl Medaka
Match: acvr1l (activin receptor type-1 [Source:NCBI gene;Acc:101166428])

HSP 1 Score: 309.301 bits (791), Expect = 5.129e-98
Identity = 163/332 (49.10%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ  L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IY++ LLRH NIL + ASDM SR   TQLWLITHYH  GSLYDYL    +  +E +++  S A GL HLHTEII G +GK +IAHRDLKSKNIL+ K    CIADLGL+V  +  + L    V S  K+GT+RYMAPE+L D +  D                             F+ +   DI+AF LV+WE+  RT+ +G   + EYK P+ D VP DPS  +M+++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:  186 SCTSGSGSGLPFLVQRTVARQTSLLECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYSTVLLRHENILEFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVETSEGLAMAASVACGLVHLHTEII-GTEGKAAIAHRDLKSKNILVTKELRCCIADLGLAVTHTQADNLL--DVGSNPKVGTKRYMAPEVLDDSIQTDC----------------------------FDAYKRVDIWAFGLVLWEIARRTYSNG--IVEEYKPPFYDQVPNDPSFEDMKKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSAR 484          
BLAST of activin receptor-1 vs. Ensembl Medaka
Match: acvr1l (activin receptor type-1 [Source:NCBI gene;Acc:101166428])

HSP 1 Score: 309.686 bits (792), Expect = 9.103e-98
Identity = 163/332 (49.10%), Postives = 210/332 (63.25%), Query Frame = 3
Query:  657 SCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDS--KSVFVLELNAMIRESWSEKSQTR 1646
            SCTSGSGSG+PFLVQRT+ARQ  L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IY++ LLRH NIL + ASDM SR   TQLWLITHYH  GSLYDYL    +  +E +++  S A GL HLHTEII G +GK +IAHRDLKSKNIL+ K    CIADLGL+V  +  + L    V S  K+GT+RYMAPE+L D +  D                             F+ +   DI+AF LV+WE+  RT+ +G   + EYK P+ D VP DPS  +M+++VCV++ RP +P+       +  L  +++E W +    R
Sbjct:  220 SCTSGSGSGLPFLVQRTVARQTSLLECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYSTVLLRHENILEFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVETSEGLAMAASVACGLVHLHTEII-GTEGKAAIAHRDLKSKNILVTKELRCCIADLGLAVTHTQADNLL--DVGSNPKVGTKRYMAPEVLDDSIQTDC----------------------------FDAYKRVDIWAFGLVLWEIARRTYSNG--IVEEYKPPFYDQVPNDPSFEDMKKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSAR 518          
BLAST of activin receptor-1 vs. Ensembl Medaka
Match: acvrl1 (serine/threonine-protein kinase receptor R3 [Source:NCBI gene;Acc:101169359])

HSP 1 Score: 300.056 bits (767), Expect = 2.178e-94
Identity = 153/331 (46.22%), Postives = 211/331 (63.75%), Query Frame = 3
Query:  660 CTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPD--SKSVFVLELNAMIRESWSEKSQTR 1646
            CTSGSG+G+P+LVQRT+ARQ+ L+  +GKGR+GEVW+G + GE VAVKIFSSRDE SW RET IYN+  LRH NILG+ ASDM S+   TQLWL+TH+H LGSLYD+L  + +    C+ +  S A GL HLHTEI+S  Q KP+IAHRDLKS+NIL+ + G+ CIADLGL+V+ +  +      V +  ++GT+RYMAPE+L + +  D                             FE +   DI+A  LV WE+  RT ++G   + +Y+ P+ D+VP DPS  EM+++VCVD+ RP L +  +    +  L  +++E W +    R
Sbjct:  182 CTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHDNILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSSLDPESCLRMCLSVACGLVHLHTEIVSS-QEKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHTQAH--DSLDVGNNPRVGTKRYMAPEVLDETIRVDV----------------------------FESYKQTDIWALGLVFWEISRRTIVNG--IVEDYRPPFFDLVPSDPSFEEMKKVVCVDQHRPSLHNRLNSHPILSALVKIMKECWYKNPTAR 479          
BLAST of activin receptor-1 vs. Planmine SMEST
Match: SMESG000019732.1 (SMESG000019732.1)

HSP 1 Score: 1111.67 bits (2874), Expect = 0.000e+0
Identity = 547/548 (99.82%), Postives = 548/548 (100.00%), Query Frame = 3
Query:   63 MQISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPXXXXXXXXXXXXXXTENLC 1706
            MQISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYN+YLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPSALRLKKNLKSLLSTENLC
Sbjct:    1 MQISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNTYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPSALRLKKNLKSLLSTENLC 548          
BLAST of activin receptor-1 vs. Planmine SMEST
Match: SMESG000068827.1 (SMESG000068827.1)

HSP 1 Score: 327.791 bits (839), Expect = 5.352e-104
Identity = 210/572 (36.71%), Postives = 314/572 (54.90%), Query Frame = 3
Query:   69 ISCICN-YAHCFE-----KKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYI---CQNSTKSLVKCC-DFNLCNK-----NSTFNNNIKPNQISNFDE-NDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFV----ENYSGL-LPLNEEEARYNRQSS--------------------LHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVL-QSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFI----SADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTR 1646
            I C C   + CF        C T  GCFK ++      G++ + C K   H   +    +  T   +KCC D + CN      +    N  +    S F   N      I  V+P C+  ++  +I +   + ++H    +LKL       ++ Y    S    +   ++  C  ++ NS NH   +    E ++G  LP ++  +    +S+                    L  D+CTSGSGSG+PFLVQRT+ARQ+ L+  IGKG+FGEVWKG + GE+VAVKIFSSR+E+SW RET+IYN+ LLRH NILGYYASD++S  GCTQLW++  YH LGSL++YL +  ++ +  + L HS AAGL HLHT I+ G QGKP+IAHRD+KSKNIL+ K    CIADLGL+V  +S  N    S  N+   +GT+RYMAPE+L +  C  ++   EN  ++    +I++ +      I  E+++    +AD+Y+++LV+WE+L+RT   G   I  Y++P+ + V  DPS  EM ++V     RP L ++    +  +  ++ E W ++   R
Sbjct:    7 IHCRCKPKSECFRYSSKGNTCATNEGCFKSVN---TKKGELTMGCFKNKTHHYLMHCKVKTWTDMEIKCCQDRDFCNDHLYLPSENLVNTTQSMSDSIFSRSNTDLRWVIAIVLPICLVIIMAGLITMFWNSLWNHKRKLHLKLEY-----QSKYYPDSSLLAIKTPLFSFPCNTNIFNSTNHRNNINWPIETFTGTGLPGSKNSSGVGVKSNGTATTVISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFSSREESSWTRETNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIM-GLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGNNEQLSENNNNRIVGTKRYMAPELL-ELACFLSNNQSENFNSNNIHLNISSTS--SIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDG--VIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKIMEECWHQRPSIR 564          
BLAST of activin receptor-1 vs. Planmine SMEST
Match: SMESG000006023.1 (SMESG000006023.1)

HSP 1 Score: 256.144 bits (653), Expect = 2.508e-76
Identity = 141/332 (42.47%), Postives = 193/332 (58.13%), Query Frame = 3
Query:  666 SGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSV-LQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLC-PDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQK-TIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVF--VLELNAMIRESWSEKSQTR 1646
            SGSG GMP + +RT A  + LI  +G+GRFG VW G + G+ VAVKIFSSRDE SWARE  +Y    LRH N+LG+  +D       T+LWL+T YH  GSL++YL + +IS  + V +  S   GL++LHTE I+G  GKP IAHRDLKS+NIL+   GE CI DLGL+V L    + L        + +GTRRYMAPEI+ D +  PD  +                           E F  ADIY+++LV+WE+L R   S    +   Y++PYQ++V  DPS  EM+ ++C  K RP +  S      + +++  +RESW E+  +R
Sbjct:  266 SGSGFGMPVMTRRTAATDISLIQAVGEGRFGTVWLGKWNGDNVAVKIFSSRDEVSWAREKDMYQQNFLRHSNVLGFVTTDRRDNGLATELWLVTDYHENGSLFEYLRAHIISIEQAVKMTRSITNGLAYLHTE-INGLDGKPGIAHRDLKSRNILVKSCGECCIGDLGLAVRLIEDCSTL------DLNNVGTRRYMAPEIILDKIVQPDMIYNGG-----------------------LEAFKKADIYSYSLVIWEILRRCECSSLNISASAYEMPYQNLVSNDPSIEEMKSIICDRKIRPPINSSWDNLNPLKDISKSVRESWFEEPASR 567          
BLAST of activin receptor-1 vs. Planmine SMEST
Match: SMESG000070956.1 (SMESG000070956.1)

HSP 1 Score: 171.014 bits (432), Expect = 9.746e-46
Identity = 111/322 (34.47%), Postives = 172/322 (53.42%), Query Frame = 3
Query:  738 IGKGRFGEVWKG------AYYGEMVAVKIFSSRDE--TSWARETHIYNSYLLR---HPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNS-KHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRP-------ELPDSKSVFVLELNAMIRESWSEKSQTR 1646
            + +GRFG+VW G       +  ++VA+KIFS   E   SW  E+ +Y+  +L+   HPNIL Y+ ++   +   T+LWL+  Y+ LGSL++YL  + +++++ + +  + AAGL+HLH+   S P   P IAHRD+KSKNIL+ +   ACIAD GL++   +T+       NS  +++GT  YMAPEIL   +    +F I +                         F+  DI++ +LV WEVL+R F      I +++ P+Q+IV  +PS  ++RQ V + K RP        LPD     V++    I E W E    R
Sbjct:  277 LAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYS--ILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS--FSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQNTD-------NSFNNRVGTLSYMAPEILEGSI----NFDIYS-------------------------FLKIDIFSMSLVFWEVLSR-FQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPD-----VIKFWKTITECWDEDPDAR 551          
BLAST of activin receptor-1 vs. Planmine SMEST
Match: SMESG000060769.1 (SMESG000060769.1)

HSP 1 Score: 138.658 bits (348), Expect = 8.311e-35
Identity = 104/323 (32.20%), Postives = 147/323 (45.51%), Query Frame = 3
Query:  747 GRFGEVWKGAYYGEM-------VAVKIFSSRDETSWARETHIYNSYLLRHPNILGYYASD-MVSRFGCTQLWLITHYHALGSLYDYLHSTVIS---FNECVSLLHSTAAGLSHLHT----EIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPEILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTR-TFLSGQKTIME-----YKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFV--LELNAMIRESWSEKSQTR 1646
            G+FGE+W G    +        VA+KI   RDE+SW  E  +Y     R   IL Y   D +V+     + WL+T Y   GSLYD L  +V +   + + +++    A GLS+LH     +  +   GKPSIAHRDLKS+NILI    +ACIADLGL+V       L    +    ++GT+RYMAPE+L   +    D                              F+  DIYA AL+MWEV ++ T   G           Y  P++  + +  +   ++  V  D  RP+LP   S F     L   I E W   ++ R
Sbjct:  188 GKFGEIWSGKLISDHSNGAIGNVAIKILRPRDESSWETEIDMYRYIRNRCSRILRYIGCDKIVTNNEIEEFWLVTQYIEYGSLYDCLSDSVRTKPNWFQVLNVCLDIAGGLSYLHEDGSYQTSAHISGKPSIAHRDLKSRNILIKADWKACIADLGLAVSFQGNRSLSDLHL----QVGTQRYMAPEVLEGAINFSRD-----------------------------SFLGIDIYAMALIMWEVFSQCTDFQGLAECEASEPSVYMQPFEQELGIHITMESLQSWVVNDNKRPQLPSQYSGFSDGQSLWRTIVECWDRDAEAR 477          
The following BLAST results are available for this feature:
BLAST of activin receptor-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ACVR15.806e-10639.40activin A receptor type 1 [Source:HGNC Symbol;Acc:... [more]
ACVR15.806e-10639.40activin A receptor type 1 [Source:HGNC Symbol;Acc:... [more]
ACVR15.806e-10639.40activin A receptor type 1 [Source:HGNC Symbol;Acc:... [more]
ACVR15.806e-10639.40activin A receptor type 1 [Source:HGNC Symbol;Acc:... [more]
ACVR15.806e-10639.40activin A receptor type 1 [Source:HGNC Symbol;Acc:... [more]
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BLAST of activin receptor-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sma-68.852e-5735.58Serine/threonine-protein kinase sma-6 [Source:Uni... [more]
daf-13.072e-5538.03Cell surface receptor daf-1 [Source:UniProtKB/Swi... [more]
daf-15.129e-5438.03Cell surface receptor daf-1 [Source:UniProtKB/Swi... [more]
daf-41.191e-2931.03Cell surface receptor daf-4 [Source:UniProtKB/Swi... [more]
daf-41.336e-2931.03Cell surface receptor daf-4 [Source:UniProtKB/Swi... [more]
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BLAST of activin receptor-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sax6.445e-9748.49gene:FBgn0003317 transcript:FBtr0088833[more]
sax1.444e-9648.49gene:FBgn0003317 transcript:FBtr0088832[more]
sax1.608e-9648.49gene:FBgn0003317 transcript:FBtr0308825[more]
babo4.477e-8245.37gene:FBgn0011300 transcript:FBtr0088659[more]
babo6.628e-8245.37gene:FBgn0011300 transcript:FBtr0300599[more]
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BLAST of activin receptor-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
acvr1l8.080e-10137.55activin A receptor, type 1 like [Source:ZFIN;Acc:Z... [more]
acvr1l8.080e-10137.55activin A receptor, type 1 like [Source:ZFIN;Acc:Z... [more]
acvrl17.191e-9847.59activin A receptor like type 1 [Source:ZFIN;Acc:ZD... [more]
acvrl19.381e-9847.59activin A receptor like type 1 [Source:ZFIN;Acc:ZD... [more]
tgfbr1a5.190e-9437.29transforming growth factor, beta receptor 1 a [Sou... [more]
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BLAST of activin receptor-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
acvr12.734e-10450.90activin A receptor type 1 [Source:NCBI gene;Acc:55... [more]
acvr15.761e-10450.90activin A receptor type 1 [Source:NCBI gene;Acc:55... [more]
acvr15.996e-10450.90activin A receptor type 1 [Source:NCBI gene;Acc:55... [more]
acvr17.729e-10450.90activin A receptor type 1 [Source:NCBI gene;Acc:55... [more]
acvr18.874e-10450.90activin A receptor type 1 [Source:NCBI gene;Acc:55... [more]
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BLAST of activin receptor-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Acvr11.112e-10439.33activin A receptor, type 1 [Source:MGI Symbol;Acc:... [more]
Acvr11.112e-10439.33activin A receptor, type 1 [Source:MGI Symbol;Acc:... [more]
Acvr11.112e-10439.33activin A receptor, type 1 [Source:MGI Symbol;Acc:... [more]
Acvr11.112e-10439.33activin A receptor, type 1 [Source:MGI Symbol;Acc:... [more]
Acvrl15.406e-9647.43activin A receptor, type II-like 1 [Source:MGI Sym... [more]
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BLAST of activin receptor-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q28041|ACVR1_BOVIN1.304e-10539.40Activin receptor type-1 OS=Bos taurus OX=9913 GN=A... [more]
sp|Q04771|ACVR1_HUMAN2.788e-10539.40Activin receptor type-1 OS=Homo sapiens OX=9606 GN... [more]
sp|P80201|ACVR1_RAT7.613e-10439.14Activin receptor type-1 OS=Rattus norvegicus OX=10... [more]
sp|P37172|ACVR1_MOUSE7.778e-10439.33Activin receptor type-1 OS=Mus musculus OX=10090 G... [more]
sp|Q90ZK6|ACVR1_CHICK1.856e-10350.15Activin receptor type-1 OS=Gallus gallus OX=9031 G... [more]
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BLAST of activin receptor-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZI740.000e+099.82Receptor protein serine/threonine kinase (Fragment... [more]
A0A2U9CBJ42.692e-10939.19Receptor protein serine/threonine kinase OS=Scopht... [more]
A0A3B3ZSP81.204e-10839.74Receptor protein serine/threonine kinase OS=Periop... [more]
A0A3Q1AWG01.309e-10838.87Receptor protein serine/threonine kinase OS=Amphip... [more]
A0A3P8THC01.823e-10838.87Receptor protein serine/threonine kinase OS=Amphip... [more]
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BLAST of activin receptor-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ACVR11.478e-10438.16activin receptor type-1 [Source:NCBI gene;Acc:1030... [more]
ACVR14.919e-10437.92activin receptor type-1 [Source:NCBI gene;Acc:1030... [more]
acvr1l4.763e-10049.40activin A receptor, type 1 like [Source:ZFIN;Acc:Z... [more]
acvr1l3.058e-9949.40activin A receptor, type 1 like [Source:ZFIN;Acc:Z... [more]
acvrl13.815e-9950.50activin receptor type-1-like [Source:NCBI gene;Acc... [more]
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BLAST of activin receptor-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000005861.16.340e-10349.40pep scaffold:Pmarinus_7.0:GL476493:320276:325221:1... [more]
ENSPMAT00000006990.13.623e-10039.25pep scaffold:Pmarinus_7.0:GL476821:19527:36497:1 g... [more]
ENSPMAT00000005886.11.670e-9948.49pep scaffold:Pmarinus_7.0:GL476493:320297:325703:1... [more]
ENSPMAT00000006012.15.448e-8946.43pep scaffold:Pmarinus_7.0:GL476493:425401:440684:1... [more]
ENSPMAT00000003828.13.902e-8847.43pep scaffold:Pmarinus_7.0:GL476610:23057:33770:1 g... [more]
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BLAST of activin receptor-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
STE204.554e-1128.26Cdc42p-activated signal transducing kinase; involv... [more]
CDC154.774e-1130.00Protein kinase of the Mitotic Exit Network; locali... [more]
KIC16.222e-1127.32Protein kinase of the PAK/Ste20 family, required f... [more]
SNF17.639e-1127.32AMP-activated S/T protein kinase; forms a complex ... [more]
SPS12.473e-1028.26Putative protein serine/threonine kinase; localize... [more]
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BLAST of activin receptor-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO490833.779e-9436.01Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO304342.179e-8334.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO418336.517e-7941.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493708.795e-4431.16Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413795.615e-3329.43Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of activin receptor-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000020918.24.620e-10637.94activin A receptor type 1 [Source:NCBI gene;Acc:10... [more]
ENSORLT00000020917.26.551e-10337.94activin A receptor type 1 [Source:NCBI gene;Acc:10... [more]
acvr1l5.129e-9849.10activin receptor type-1 [Source:NCBI gene;Acc:1011... [more]
acvr1l9.103e-9849.10activin receptor type-1 [Source:NCBI gene;Acc:1011... [more]
acvrl12.178e-9446.22serine/threonine-protein kinase receptor R3 [Sourc... [more]
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BLAST of activin receptor-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000019732.10.000e+099.82SMESG000019732.1[more]
SMESG000068827.15.352e-10436.71SMESG000068827.1[more]
SMESG000006023.12.508e-7642.47SMESG000006023.1[more]
SMESG000070956.19.746e-4634.47SMESG000070956.1[more]
SMESG000060769.18.311e-3532.20SMESG000060769.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30027370
GenBankAFJ24728.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027370 ID=SMED30027370|Name=activin receptor-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1836bp
ATTAATTATACAATTTTAATTTGCAAATTTTATTTAATATTTTGATTAAA
GCTTTTTAAGAAATGCAAATTAGCTGTATTTGTAATTATGCACACTGTTT
TGAAAAAAAATGTAAAACGTATTTTGGATGCTTTAAATTAATCTCATTGT
ATGGTAATGATACCGGTAAAATTTATTTGGATTGCTTAAAGGAATCTATT
CACGATTCATATATTTGTCAAAATTCAACCAAAAGTTTAGTAAAATGTTG
TGATTTTAATCTATGTAACAAAAATTCAACGTTTAATAACAATATTAAAC
CAAATCAAATTTCAAATTTTGATGAAAATGATTATTATTCTCTCTCAATC
AAATTTGTTATTCCATTTTGTGTTGCTGCGATGATCCTTCTAGTAATCTG
CTTAATTATGTTCAATAAATATCATCACAATTTATCGAGATACCTCAAAT
TGTATTCAAATTTTACGATTTCTCGTACTAATTACACTCGCCAACTTTCT
GAAAATCAAACCGAATTTAAACCATACGCCGATGATTGTGAACGAAGTTT
GTCGAATTCTAATAACCACAGCAGATTTGTTGAAAATTATTCTGGTTTGT
TACCTCTTAATGAAGAAGAAGCACGATATAATCGTCAATCATCTTTACAC
TGTGATTCATGCACAAGTGGCAGTGGATCAGGAATGCCTTTTCTTGTCCA
GCGGACTATTGCCCGACAGGTTCAATTAATAAATGGTATTGGTAAAGGTC
GTTTTGGAGAAGTATGGAAAGGAGCTTATTATGGTGAAATGGTAGCAGTT
AAGATATTTTCAAGCCGTGATGAAACTAGTTGGGCTCGCGAAACTCATAT
ATATAATTCATATTTACTGCGTCATCCAAATATTCTGGGATATTATGCAT
CAGATATGGTTTCTAGATTTGGATGTACACAATTGTGGTTAATTACTCAC
TATCATGCCTTAGGATCTCTTTATGACTATTTACATTCTACTGTTATTTC
TTTCAATGAATGTGTAAGTTTATTGCACAGTACAGCTGCTGGATTATCAC
ATCTTCACACGGAAATAATTTCCGGACCTCAAGGAAAGCCATCAATTGCC
CATCGTGATTTAAAATCGAAAAATATTCTCATTATCAAACCCGGCGAAGC
TTGCATTGCAGATTTAGGGCTATCGGTTCTTCAGTCTTCTACGAATTGTC
TTTGTCCTTCTCCAGTAAATAGCAAACATAAAATCGGTACTCGGCGTTAC
ATGGCGCCGGAAATCCTTGCCGATTGTCTGTGTCCCGACACAGATTTCAC
AATCGAAAACTGTCTCGCCGATCCCACATCCCCTAGCATCGCTACCGTAA
CGCAACACGAAGCTTGTCCGATTCGATTTGAGCATTTTATTTCCGCTGAT
ATTTATGCGTTCGCTCTCGTCATGTGGGAAGTCTTGACTCGCACATTTTT
ATCGGGACAGAAAACTATAATGGAATACAAAGTACCGTATCAAGATATTG
TGCCACTTGATCCCAGCACTCCAGAAATGCGTCAGTTGGTATGCGTAGAT
AAGTTCCGTCCCGAGTTGCCCGATTCCAAATCTGTTTTTGTGTTAGAATT
GAATGCAATGATTCGTGAAAGCTGGTCGGAAAAGTCACAAACCCGACCGA
GTGCTTTGCGTTTAAAGAAAAATTTGAAATCTCTTTTATCGACTGAAAAT
CTGTGTTAAAACTTTTTTTCAATATTTTTACGTACCTAATGTCTCTTTCG
GAGGTTTTAGATCTGATGTTAATGCTTATCGATTTTGTCGTTTTATGTAC
ATTTTAATGGAAATATATTTTTTATTGTCAGAAAAA
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protein sequence of SMED30027370-orf-1

>SMED30027370-orf-1 ID=SMED30027370-orf-1|Name=SMED30027370-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=549bp
MQISCICNYAHCFEKKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSY
ICQNSTKSLVKCCDFNLCNKNSTFNNNIKPNQISNFDENDYYSLSIKFVI
PFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQT
EFKPYADDCERSLSNSNNHSRFVENYSGLLPLNEEEARYNRQSSLHCDSC
TSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFS
SRDETSWARETHIYNSYLLRHPNILGYYASDMVSRFGCTQLWLITHYHAL
GSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDL
KSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKIGTRRYMAPE
ILADCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAF
ALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRP
ELPDSKSVFVLELNAMIRESWSEKSQTRPSALRLKKNLKSLLSTENLC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000034epidermis
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR000333TGFB_receptor
IPR003605GS_dom
IPR000719Prot_kinase_dom
IPR017441Protein_kinase_ATP_BS
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0016310phosphorylation
GO:0023014signal transduction by protein phosphorylation
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: molecular function
TermDefinition
GO:0004675transmembrane receptor protein serine/threonine kinase activity
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0004702signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 220..542
e-value: 2.1E-16
score: 70.5
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 223..403
e-value: 1.1E-24
score: 87.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 220..542
score: 33.813
IPR003605GS domainSMARTSM00467GS_4coord: 190..220
e-value: 6.5E-10
score: 48.9
IPR003605GS domainPFAMPF08515TGF_beta_GScoord: 197..218
e-value: 1.8E-13
score: 49.7
IPR003605GS domainPROSITEPS51256GScoord: 174..219
score: 14.534
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 300..546
e-value: 9.2E-42
score: 145.0
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 185..299
e-value: 5.5E-45
score: 154.0
NoneNo IPR availableTMHMMTMhelixcoord: 96..118
IPR000333Ser/Thr protein kinase, TGFB receptorPANTHERPTHR23255TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND IIcoord: 438..543
coord: 4..404
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 226..247
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 345..357
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 198..538