TPR_REGION domain-containing protein

Overview
NameTPR_REGION domain-containing protein
Smed IDSMED30027225
Length (bp)1920
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TPR_REGION domain-containing protein (SMED30027225) t-SNE clustered cells

Violin plots show distribution of expression levels for TPR_REGION domain-containing protein (SMED30027225) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TPR_REGION domain-containing protein (SMED30027225) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TPR_REGION domain-containing protein (SMED30027225) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027225

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30027225h1SMcG0016524 dd_Smed_v4_3570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30027225h1SMcG0016524 dd_Smed_v4_3570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30027225h1SMcG0016524 dd_Smed_v4_3570_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30027225h1SMcG0016524 dd_Smed_v4_3570_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Human
Match: FBXO9 (F-box protein 9 [Source:HGNC Symbol;Acc:HGNC:13588])

HSP 1 Score: 87.8113 bits (216), Expect = 8.274e-18
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLK---LPSQIETIDRHRQERAPESSYNGHKEGQSKILE---------------LPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P       S IE  D   +     S +      Q  +L+               LP E+L++I RW+V   LDL ++  + L               VC  F+  A D +IWRL   ++W    +  +     SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++PQ I+
Sbjct:   48 EKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSL---------------VCRGFYICARDPEIWRLACLKVWGRSCIKLVPY--TSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIV 277
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Human
Match: FBXO9 (F-box protein 9 [Source:HGNC Symbol;Acc:HGNC:13588])

HSP 1 Score: 86.6557 bits (213), Expect = 1.955e-17
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLK---LPSQIETIDRHRQERAPESSYNGHKEGQSKILE---------------LPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P       S IE  D   +     S +      Q  +L+               LP E+L++I RW+V   LDL ++  + L               VC  F+  A D +IWRL   ++W    +  +     SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++PQ I+
Sbjct:   82 EKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSL---------------VCRGFYICARDPEIWRLACLKVWGRSCIKLVPY--TSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIV 311
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Human
Match: FBXO9 (F-box protein 9 [Source:HGNC Symbol;Acc:HGNC:13588])

HSP 1 Score: 86.6557 bits (213), Expect = 2.066e-17
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLK---LPSQIETIDRHRQERAPESSYNGHKEGQSKILE---------------LPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P       S IE  D   +     S +      Q  +L+               LP E+L++I RW+V   LDL ++  + L               VC  F+  A D +IWRL   ++W    +  +     SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++PQ I+
Sbjct:   92 EKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSL---------------VCRGFYICARDPEIWRLACLKVWGRSCIKLVPY--TSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIV 321
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Fly
Match: CG5961 (gene:FBgn0038056 transcript:FBtr0340187)

HSP 1 Score: 97.4413 bits (241), Expect = 3.290e-21
Identity = 116/447 (25.95%), Postives = 192/447 (42.95%), Query Frame = 3 
Query:  183 NTIESLREEWIKEINIRKHEIENGELCLSEYRVEL----------------AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIE------KMIKLRNNPLK--------LPSQI--------ETID----RHRQERAPESSYNGHKEGQSK----------ILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWP------DCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVF-APXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESI-AANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXN--PFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTV-THFDCKGGKFPTVVFSRVREF 1334
            N ++  RE W +E+  ++H    G    SE    L                A  +Y +  + E RG +  A+  YR+AT +V DIE      +  KL N+  K        L  Q+        E +D    + + +   ++ YNG     S+            +LP EI++ I RW+V  QLD+ +          L  C       VC  F+  A DE++WRL   ++W       +   +D+     SW  M   R  +LF+GCY+  T+Y+R GE +F   F  P  LV Y+R  RF  DG V+M+T+A +P               +SKL+ +      +  G++ + G  VT+ + +      A  R  R +  P +E     + +  +I  + +R  + L W  ++L    RN++ + + FD    K+P + FS V+ +
Sbjct:   18 NALDEFRENWQREL--QEHTTNTGSRSHSEAGDRLTAANSNLSEADLLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRFYEQQKQKLSNDVSKKYLNLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDANVLTTGLHFADLPPEIVMRILRWVVSAQLDMRS----------LEQCAA-----VCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFHSWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADEP------------AQGVSKLKHVNNVRAEMLRGRYRLFGSTVTLVLQKSQQRGPANVRQRRGSIMPVDEDSSQFL-IELRIAGTTKRRCAQLVWSHYTL-VQKRNKVDISSEFDLTEAKYPALRFSTVKSY 433
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Fly
Match: CG5961 (gene:FBgn0038056 transcript:FBtr0303029)

HSP 1 Score: 97.4413 bits (241), Expect = 3.290e-21
Identity = 116/447 (25.95%), Postives = 192/447 (42.95%), Query Frame = 3 
Query:  183 NTIESLREEWIKEINIRKHEIENGELCLSEYRVEL----------------AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIE------KMIKLRNNPLK--------LPSQI--------ETID----RHRQERAPESSYNGHKEGQSK----------ILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWP------DCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVF-APXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESI-AANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXN--PFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTV-THFDCKGGKFPTVVFSRVREF 1334
            N ++  RE W +E+  ++H    G    SE    L                A  +Y +  + E RG +  A+  YR+AT +V DIE      +  KL N+  K        L  Q+        E +D    + + +   ++ YNG     S+            +LP EI++ I RW+V  QLD+ +          L  C       VC  F+  A DE++WRL   ++W       +   +D+     SW  M   R  +LF+GCY+  T+Y+R GE +F   F  P  LV Y+R  RF  DG V+M+T+A +P               +SKL+ +      +  G++ + G  VT+ + +      A  R  R +  P +E     + +  +I  + +R  + L W  ++L    RN++ + + FD    K+P + FS V+ +
Sbjct:   18 NALDEFRENWQREL--QEHTTNTGSRSHSEAGDRLTAANSNLSEADLLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRFYEQQKQKLSNDVSKKYLNLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDANVLTTGLHFADLPPEIVMRILRWVVSAQLDMRS----------LEQCAA-----VCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFHSWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADEP------------AQGVSKLKHVNNVRAEMLRGRYRLFGSTVTLVLQKSQQRGPANVRQRRGSIMPVDEDSSQFL-IELRIAGTTKRRCAQLVWSHYTL-VQKRNKVDISSEFDLTEAKYPALRFSTVKSY 433
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Fly
Match: CG5961 (gene:FBgn0038056 transcript:FBtr0082681)

HSP 1 Score: 97.4413 bits (241), Expect = 3.290e-21
Identity = 116/447 (25.95%), Postives = 192/447 (42.95%), Query Frame = 3 
Query:  183 NTIESLREEWIKEINIRKHEIENGELCLSEYRVEL----------------AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIE------KMIKLRNNPLK--------LPSQI--------ETID----RHRQERAPESSYNGHKEGQSK----------ILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWP------DCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVF-APXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESI-AANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXN--PFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTV-THFDCKGGKFPTVVFSRVREF 1334
            N ++  RE W +E+  ++H    G    SE    L                A  +Y +  + E RG +  A+  YR+AT +V DIE      +  KL N+  K        L  Q+        E +D    + + +   ++ YNG     S+            +LP EI++ I RW+V  QLD+ +          L  C       VC  F+  A DE++WRL   ++W       +   +D+     SW  M   R  +LF+GCY+  T+Y+R GE +F   F  P  LV Y+R  RF  DG V+M+T+A +P               +SKL+ +      +  G++ + G  VT+ + +      A  R  R +  P +E     + +  +I  + +R  + L W  ++L    RN++ + + FD    K+P + FS V+ +
Sbjct:   18 NALDEFRENWQREL--QEHTTNTGSRSHSEAGDRLTAANSNLSEADLLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRFYEQQKQKLSNDVSKKYLNLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDANVLTTGLHFADLPPEIVMRILRWVVSAQLDMRS----------LEQCAA-----VCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFHSWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADEP------------AQGVSKLKHVNNVRAEMLRGRYRLFGSTVTLVLQKSQQRGPANVRQRRGSIMPVDEDSSQFL-IELRIAGTTKRRCAQLVWSHYTL-VQKRNKVDISSEFDLTEAKYPALRFSTVKSY 433
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Zebrafish
Match: fbxo9 (F-box protein 9 [Source:NCBI gene;Acc:325469])

HSP 1 Score: 83.1889 bits (204), Expect = 1.797e-16
Identity = 76/279 (27.24%), Postives = 123/279 (44.09%), Query Frame = 3 
Query:  189 IESLREEWIKEINI----RKHEIENGELCLSE--YRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRN--NPLKLPSQIETIDRHRQ---------------ERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDP 956
            + + R +W+ E+      ++    N EL   +   + E A  ++    E E  G +  A++ Y+ A  LV DIE  I      +P +  S +E+ + +R+                 A +   +  +  Q  I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWR    R+W       L     SW  M   RP + F G Y+  TSY+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DP
Sbjct:   29 LSAFRAKWMSELQPSSGGQRSFSRNAELRRRQETAKEEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYSRTPDPERGGSYLESSENNREIDDLLTYFQHQLTLGNDAMKLCEHETETSQVHISALPFEVLMYIFRWVVSCDLDLRALEQLSLV---------------CRGFYICARDPEIWRSACLRVWGRSCTKMLPY--SSWREMFLERPRVRFDGVYISKTSYIRQGEESLDGFYRAWHQVEYYRYLRFFPDGQVMMLTTPEDP 290
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Xenopus
Match: FBXO9 (F-box protein 9 [Source:NCBI gene;Acc:394601])

HSP 1 Score: 86.2705 bits (212), Expect = 9.035e-18
Identity = 76/271 (28.04%), Postives = 119/271 (43.91%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLR--------------NNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQI-SKLESIAANYSIASGQF 1055
            A  ++    E E  G L  A++ YR+A  LV DIE  I                 NN  K+   +    +    +  +         Q+ I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWRL   ++W    V  +     +W  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DPQ I+         P++ +K  S+  N S+ S  F
Sbjct:   81 ARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLV---------------CKGFYICARDPEIWRLACLKVWGRNCVKIVPY--TTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIV---------PRLRTKNASLCFNVSLISAPF 325
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Xenopus
Match: FBXO9 (F-box protein 9 [Source:NCBI gene;Acc:394601])

HSP 1 Score: 85.8853 bits (211), Expect = 3.356e-17
Identity = 69/241 (28.63%), Postives = 107/241 (44.40%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLR--------------NNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            A  ++    E E  G L  A++ YR+A  LV DIE  I                 NN  K+   +    +    +  +         Q+ I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWRL   ++W    V  +     +W  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DPQ I+
Sbjct:   70 ARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLV---------------CKGFYICARDPEIWRLACLKVWGRNCVKIVPY--TTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIV 293
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Xenopus
Match: FBXO9 (F-box protein 9 [Source:NCBI gene;Acc:394601])

HSP 1 Score: 85.5001 bits (210), Expect = 3.847e-17
Identity = 69/241 (28.63%), Postives = 107/241 (44.40%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLR--------------NNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            A  ++    E E  G L  A++ YR+A  LV DIE  I                 NN  K+   +    +    +  +         Q+ I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWRL   ++W    V  +     +W  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DPQ I+
Sbjct:   81 ARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLV---------------CKGFYICARDPEIWRLACLKVWGRNCVKIVPY--TTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIV 304
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Xenopus
Match: FBXO9 (F-box protein 9 [Source:NCBI gene;Acc:394601])

HSP 1 Score: 85.5001 bits (210), Expect = 4.495e-17
Identity = 69/241 (28.63%), Postives = 107/241 (44.40%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLR--------------NNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            A  ++    E E  G L  A++ YR+A  LV DIE  I                 NN  K+   +    +    +  +         Q+ I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWRL   ++W    V  +     +W  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DPQ I+
Sbjct:   81 ARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLV---------------CKGFYICARDPEIWRLACLKVWGRNCVKIVPY--TTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIV 304
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Xenopus
Match: FBXO9 (F-box protein 9 [Source:NCBI gene;Acc:394601])

HSP 1 Score: 83.9593 bits (206), Expect = 1.319e-16
Identity = 69/246 (28.05%), Postives = 107/246 (43.50%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLR-------------------NNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            A  ++    E E  G L  A++ YR+A  LV DIE  I                      NN  K+   +    +    +  +         Q+ I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWRL   ++W    V  +     +W  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DPQ I+
Sbjct:   50 ARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNLVRGSGLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLV---------------CKGFYICARDPEIWRLACLKVWGRNCVKIVPY--TTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIV 278
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Mouse
Match: Fbxo9 (f-box protein 9 [Source:MGI Symbol;Acc:MGI:1918788])

HSP 1 Score: 83.9593 bits (206), Expect = 1.212e-16
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP----------------LKLPSQIETIDRHR--QERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P                 K+   +    +    QE   +      +  Q+ I  LP E+L++I RW+V   LDL ++  + LV               C  F+  A D +IWRL   ++W   S   L  Y  SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P  I+
Sbjct:   81 EKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLV---------------CRGFYICARDPEIWRLACLKVWGR-SCMKLVPY-ASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIV 310
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Mouse
Match: Fbxo9 (f-box protein 9 [Source:MGI Symbol;Acc:MGI:1918788])

HSP 1 Score: 83.5741 bits (205), Expect = 1.346e-16
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP----------------LKLPSQIETIDRHR--QERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P                 K+   +    +    QE   +      +  Q+ I  LP E+L++I RW+V   LDL ++  + LV               C  F+  A D +IWRL   ++W   S   L  Y  SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P  I+
Sbjct:   82 EKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLV---------------CRGFYICARDPEIWRLACLKVWGR-SCMKLVPY-ASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIV 311
[Close]
BLAST of TPR_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q3ZBT2|FBX9_BOVIN (F-box only protein 9 OS=Bos taurus OX=9913 GN=FBXO9 PE=2 SV=2)

HSP 1 Score: 87.8113 bits (216), Expect = 4.033e-17
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLK---LPSQIETIDRHR---------------QERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P       S IE  D                  QE   +      +  Q+ I  LP E+L+++ RW+V   LDL ++  +                QVC  F+  A D +IWRL   ++W    +  +     SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++PQ I+
Sbjct:   82 EKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDTDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQTHISALPMEVLMYVFRWVVSSDLDLRSLEQLS---------------QVCRGFYICARDPEIWRLACLKVWGRSCIKLVPY--TSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYVRFFPDGHVMMLTTPEEPQSIV 311
[Close]
BLAST of TPR_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9UK97|FBX9_HUMAN (F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1)

HSP 1 Score: 86.6557 bits (213), Expect = 9.919e-17
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLK---LPSQIETIDRHRQERAPESSYNGHKEGQSKILE---------------LPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P       S IE  D   +     S +      Q  +L+               LP E+L++I RW+V   LDL ++  + L               VC  F+  A D +IWRL   ++W    +  +     SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++PQ I+
Sbjct:   92 EKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSL---------------VCRGFYICARDPEIWRLACLKVWGRSCIKLVPY--TSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIV 321
[Close]
BLAST of TPR_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|F6Y9J3|FBX9_XENTR (F-box only protein 9 OS=Xenopus tropicalis OX=8364 GN=fbxo9 PE=3 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 2.381e-16
Identity = 69/241 (28.63%), Postives = 107/241 (44.40%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLR--------------NNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            A  ++    E E  G L  A++ YR+A  LV DIE  I                 NN  K+   +    +    +  +         Q+ I  LP E+L++I RW+V   LDL  +  + LV               C  F+  A D +IWRL   ++W    V  +     +W  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DPQ I+
Sbjct:   81 ARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLV---------------CKGFYICARDPEIWRLACLKVWGRNCVKIVPY--TTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIV 304
[Close]
BLAST of TPR_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5U2X1|FBX9_RAT (F-box only protein 9 OS=Rattus norvegicus OX=10116 GN=Fbxo9 PE=1 SV=1)

HSP 1 Score: 83.9593 bits (206), Expect = 8.354e-16
Identity = 70/247 (28.34%), Postives = 110/247 (44.53%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP----------------LKLPSQIETIDRHR--QERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P                 K+   +    +    QE   +      +  Q+ I  LP E+L++I RW+V   LDL ++  + LV               C  F+  A D +IWRL   ++W    +  +     SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P  I+
Sbjct:   80 EKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSSYIEDNEDASKMADLLSYFQQQLTFQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLV---------------CRGFYICARDPEIWRLACLKVWGRSCMKLVPF--SSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPPSIV 309
[Close]
BLAST of TPR_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8BK06|FBX9_MOUSE (F-box only protein 9 OS=Mus musculus OX=10090 GN=Fbxo9 PE=1 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 9.417e-16
Identity = 73/247 (29.55%), Postives = 111/247 (44.94%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP----------------LKLPSQIETIDRHR--QERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YRRA  LV DIE  I    +P                 K+   +    +    QE   +      +  Q+ I  LP E+L++I RW+V   LDL ++  + LV               C  F+  A D +IWRL   ++W   S   L  Y  SW  M   RP + F G Y+  T+Y+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P  I+
Sbjct:   82 EKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLV---------------CRGFYICARDPEIWRLACLKVWGR-SCMKLVPY-ASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIV 311
[Close]
BLAST of TPR_REGION domain-containing protein vs. TrEMBL
Match: B0X0N5 (F-box only protein 9 OS=Culex quinquefasciatus OX=7176 GN=6045930 PE=4 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 1.813e-28
Identity = 124/429 (28.90%), Postives = 184/429 (42.89%), Query Frame = 3 
Query:  186 TIESLREEWIKEINIRKHEIENGELCLSEYRVEL-----AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPS--------------------------QIETID------------RHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYE-GSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVF-APXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLD-RTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREF 1334
            T++  RE W +E+       +N  +   +    L     A  ++  G E E  G +  A+  YRRA  LV DIE  +  +  P K  S                           +E +D            R   ERA  S   G     +   +LP E++L+I RW+V   LDL ++   G               +VC  F+ LA D +IWR    RLW   +V +L      SW  M   RP + FHGCY+  TSY+R GE +F   F  P  LV Y+R FRF  DGSV+M+TSA++PQ     +G L  R+P             I  G + +  D + + + R  S   + R   +     E  +  + +   I  + +R  S L WR +S+  +  N+ T T F+    K+PT+ FSRV+ +
Sbjct:   33 TLDEFRERWQQELKKEPGTAQNVAVAQQDQNQNLSVEQRARALFLEGSEMERVGKVFEAMRLYRRAVQLVPDIEFRVYEKRTPAKQASGDVSASSEIDALSNELLEVTLDEDDENLENVDLVLRFQNLLAKSRKLFERA--SGDRGLIVTSAHFSDLPMEVILYILRWVVSSDLDLRSMERFG---------------RVCRGFYLLARDPEIWRRACVRLW-GVNVGNLKGSPFASWREMYINRPRVHFHGCYISRTSYLRYGENSFQDQFYRPVQLVEYYRYFRFFADGSVLMLTSAEEPQSC---VGKLKPRSP---------VQNEILKGHYRLRNDELIIAVQRKRSNVQSQRPGRKKEIEAEFGQQTLYLELGIVSTAKRAFSQLHWRQYSMVQLRNNQETTTTFELNSSKYPTLFFSRVKSY 431
[Close]
BLAST of TPR_REGION domain-containing protein vs. TrEMBL
Match: A0A2T7PGK6 (F-box domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_07939 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 5.275e-28
Identity = 110/406 (27.09%), Postives = 190/406 (46.80%), Query Frame = 3 
Query:  189 IESLREEWIKEINIR-KHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKL--RNNPLKLP--------SQIETIDR----HRQE-RAPESSY--NGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLW-PDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANY-SIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFV--VRNEMTVTHFDCKGGKFPTVVFSRVREFSS 1340
            ++  RE+W  E+    +   ++G+   S+   E A +++  G +AE  G++  AV+ YR A  LV DIE  I      NP +          S  E ID     H Q  R   SS     +++  + I +LP E+L++I  W+V  +LD+ ++ ++                +VC  F+  A DE +W+ I  ++W  +C  +      G+W  M   RPHLLF+GCY+   +Y R+GE   +  + PF +V Y+R  RF  DGS++MV S ++P  +            + KL +I   +  + +G + +        + R+  +    R   R    +  I    S+ F++  S RR +  L W ++S+  +       +V  FD K   +P ++FSRVR +++
Sbjct:   36 LQEFREQWQHELQAAGQQNSDSGQQRSSKSVEEEAKKLFLQGMQAEQNGHMYEAVQFYRHAMQLVPDIEFKIDFPQNRNPRERQDSESSMDGSACEEIDEDLVMHFQNIRLSNSSICEPAYEQRATHICKLPVEVLMYIFYWVVSSELDVRSLEMLS---------------EVCRGFYLCARDENLWKAICLKIWGKNCGSSKK---YGTWRRMYLDRPHLLFNGCYISRATYFRQGEQGMDQFYRPFHMVEYYRYVRFFPDGSMLMVCSPEEPSTV------------LPKLRTITYRFQGLLTGYYKLYSTKAVCVLKRVKLMEPVTRYKRRQPANQNDIDQTYSVEFEMVDSGRRRHCRLNWLAYSVCTLHKASGHESVAQFDLKSSAYPPLIFSRVRSYTA 411
[Close]
BLAST of TPR_REGION domain-containing protein vs. TrEMBL
Match: A0A4Y2ERN0 (F-box only protein 9 OS=Araneus ventricosus OX=182803 GN=fbxo9 PE=4 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 7.128e-27
Identity = 122/431 (28.31%), Postives = 194/431 (45.01%), Query Frame = 3 
Query:  189 IESLREEWIKEINI---RKHEIENGELCLS----EYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYN---------------GHKEGQSKILE------------LPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATF-NTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDP-QDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXNPFE--------EPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVR-NEMTVTHFDCKGGKFPTVVFSRVREFSSRA 1346
            +++ R +W +EI +   ++    + EL L     E   E A  ++  G +AE  G LQ A+  YRRA  LV DIE  I+  N        IE  +  + +    SS +                 K G S+I E            LP EI L+I +W+VG  LD+Y++  +                +VC  F+  + D ++W LI  R W D ++ + + Y GSW  M   RPHL F+G Y+  T+YVR GE++F +T + P  LV Y+R  RF  D +V+M+T+  DP Q I +L     + P            ++ +G+F + G+ V V  ++        +     N +         E  +    +  ++K  ++R N  L W  +S   V R  E  VT FD     FP+  FSRV+ +++ +
Sbjct:   46 LDNFRLQWKREIELSPNKEKASSSTELILDKKNEESIEEKAKALFLKGVQAEKNGKLQDAISLYRRAIQLVPDIEFRIQ-ENMEDNFNENIENSESDKSDSEENSSSDEDDDIDNLINKFKKLAFKAGTSRICEPKHEQKMSHMSCLPPEIFLYILKWVVGENLDIYSLEKIA---------------KVCRGFYLCSRDPELWHLICLRTW-DMNIDNPNKY-GSWRNMYIQRPHLNFNGVYISKTTYVRYGESSFQDTHYKPCFLVAYYRYLRFFPDDTVLMLTTPDDPYQSIYKLRHKTAKDP------------NVHTGRFKLVGNTV-VAAVKKSKSEIVTQPTNFYNRYRRQRQANLPEIQEQTYHLELEVKNYKKRINCQLAWMRYSTHVVYRIGEEAVTEFDILPSTFPSFWFSRVKSYTAES 445
[Close]
BLAST of TPR_REGION domain-containing protein vs. TrEMBL
Match: V3ZU41 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_235671 PE=4 SV=1)

HSP 1 Score: 124.02 bits (310), Expect = 1.227e-26
Identity = 104/407 (25.55%), Postives = 185/407 (45.45%), Query Frame = 3 
Query:  189 IESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQ-------IETIDRHRQERAPESSYNGHKE-----------GQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXX---NPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFV--VRNEMTVTHFDCKGGKFPTVVFSRVREFSS 1340
            +E  R+EW +E+N        G     + + E A  +Y  G EAE  G   +AV  Y++A  LV DIE   K+     + P +       +E++ +  +E   E+  N H E             + I ELP E++++I RW+V  +LD+ ++ I+                QVC  F+  A DE++W+ I +++W    +  +  Y G++  M   RPHLLF+GCY+  TSY+R GE + ++ + P+ ++ YFR  R   DGS++   +   PQ  +         P++           +  GQF   G+ V  ++++  S  +               + I +   + F+I    +  ++ L W  + +S      N+ +V+  D     FP + FSRV+ +++
Sbjct:   47 LEDFRQEWKQELNKGSG---GGPDRQPQSKEERAKSLYLRGAEAEQNGDFYIAVGFYKKAIQLVPDIE--FKIDYTTTRTPRERQDSECSVESL-KTEEEDLLENFQNMHLEDNRLCTQEVAQNSTHISELPIEVIMYILRWVVSSELDVRSLEILS---------------QVCRGFYLCARDEELWKTICSKIWGGAKIGKVKKY-GNYRKMYLERPHLLFNGCYISKTSYIRNGEQSLDSFYRPYHIIEYFRYVRLFSDGSILTFCTFDRPQAAV---------PKLR--HKWIKESGLLKGQFKQVGNKVIAELVQSRSNQNQNSGYKYKRRQKNQNDCIYNNYHIEFEISSGGKGIHNILTWTKYYISTFNGGTNKSSVSDIDLTPKMFPPMSFSRVKSYNN 420
[Close]
BLAST of TPR_REGION domain-containing protein vs. TrEMBL
Match: A0A182M1F4 (Uncharacterized protein OS=Anopheles culicifacies OX=139723 PE=4 SV=1)

HSP 1 Score: 124.02 bits (310), Expect = 1.437e-26
Identity = 114/394 (28.93%), Postives = 172/394 (43.65%), Query Frame = 3 
Query:  288 AHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIE--------------------KMIK------LRNNPLKLPSQIETID---RHRQERAPESSYNGHKEGQSKIL-------ELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEG----SWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVF-APXXXXXXXXXXXXXXDGSVVMVTSAQDPQD-IIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIR---ICSVXXXXXXXXXXNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREF 1334
            A  +++ G E E  G +  A+  YRRAT LV DIE                    +M++      +  N  +    +E +D   R +   A          G  K++       +LP E++L+I RW+V   LDL ++                    VC  F+ LA D +IWR    R+W      +L + +G    SW  M   RP +LFHGCY+  TSY+R GE +F   F  P  LV Y+R FRF  DG V+M+T+A +PQ  +++L     R+P         A   I  G + ++ D+V V + R     S            P  E  +    M  QI  + +RP S L W+ +++     N+   T FD    K+P + FSRV+ +
Sbjct:   72 ARTLFQQGSELERSGKVFEAMRLYRRATQLVPDIEFRVYDKKHLKPQDDAHDANARMVEGLMERMMEANIDEDEENLENVDLALRFQTLMARSGKLFERASGDRKLIVTAAHFSDLPMELILYILRWVVSNDLDLKSLERFA---------------SVCRGFYLLARDPEIWRHACMRIWG----VNLGVLKGTPFSSWREMYINRPRMLFHGCYISRTSYLRSGENSFQDQFYRPIQLVEYYRYFRFFADGKVLMLTTADEPQQCVVKLKS---RSP---------AQNEILRGHYRLHDDVVIVVIQRNRPTASAQMQRPGRRVREPEPEYGQQTFLMELQIVSTAKRPFSQLHWKQYTMVQHRNNQEKTTQFDLTTTKYPPLYFSRVKSY 434
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Cavefish
Match: fbxo9 (F-box protein 9 [Source:NCBI gene;Acc:103045917])

HSP 1 Score: 80.8777 bits (198), Expect = 9.089e-16
Identity = 76/282 (26.95%), Postives = 121/282 (42.91%), Query Frame = 3 
Query:  189 IESLREEWIKEI---NIRKHEIENGELCLSE--YRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP--------------------LKLPSQIETIDRHRQERA-PESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDP 956
            + + R +W+ E+   + RK   +  +L   +   R E A  ++    E E  G +  A++ Y+ A  LV DIE  I    +P                    L    Q  T++   Q+   PE   +     Q  I  LP E+L++I RW+V   LD+  +  + LV               C  F+  A D +IWR    R+W       L     SW  M   RP + + G Y+  TSY+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P
Sbjct:   34 LSAFRAQWMSELLPSSARKGSSKAADLKKRQDLVREEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYNRSPDPDRVGGSYMEENENEIDDLLTYFQQQMTVEHSSQKLCQPEVELS-----QVHISALPLEVLMYIFRWVVSCDLDMRALEQLSLV---------------CRGFYICARDPEIWRSACLRVWGRSCTKMLPF--TSWRDMFIERPRVRYDGVYISKTSYIRQGEESLDGFYRKWHQVEYYRYLRFFPDGQVMMLTTPEEP 293
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Cavefish
Match: fbxo9 (F-box protein 9 [Source:NCBI gene;Acc:103045917])

HSP 1 Score: 80.4925 bits (197), Expect = 9.527e-16
Identity = 76/282 (26.95%), Postives = 121/282 (42.91%), Query Frame = 3 
Query:  189 IESLREEWIKEI---NIRKHEIENGELCLSE--YRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP--------------------LKLPSQIETIDRHRQERA-PESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDP 956
            + + R +W+ E+   + RK   +  +L   +   R E A  ++    E E  G +  A++ Y+ A  LV DIE  I    +P                    L    Q  T++   Q+   PE   +     Q  I  LP E+L++I RW+V   LD+  +  + LV               C  F+  A D +IWR    R+W       L     SW  M   RP + + G Y+  TSY+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P
Sbjct:   30 LSAFRAQWMSELLPSSARKGSSKAADLKKRQDLVREEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYNRSPDPDRVGGSYMEENENEIDDLLTYFQQQMTVEHSSQKLCQPEVELS-----QVHISALPLEVLMYIFRWVVSCDLDMRALEQLSLV---------------CRGFYICARDPEIWRSACLRVWGRSCTKMLPF--TSWRDMFIERPRVRYDGVYISKTSYIRQGEESLDGFYRKWHQVEYYRYLRFFPDGQVMMLTTPEEP 289
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Cavefish
Match: fbxo9 (F-box protein 9 [Source:NCBI gene;Acc:103045917])

HSP 1 Score: 80.1073 bits (196), Expect = 1.001e-15
Identity = 76/282 (26.95%), Postives = 121/282 (42.91%), Query Frame = 3 
Query:  189 IESLREEWIKEI---NIRKHEIENGELCLSE--YRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNP--------------------LKLPSQIETIDRHRQERA-PESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDP 956
            + + R +W+ E+   + RK   +  +L   +   R E A  ++    E E  G +  A++ Y+ A  LV DIE  I    +P                    L    Q  T++   Q+   PE   +     Q  I  LP E+L++I RW+V   LD+  +  + LV               C  F+  A D +IWR    R+W       L     SW  M   RP + + G Y+  TSY+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ ++P
Sbjct:   30 LSAFRAQWMSELLPSSARKGSSKAADLKKRQDLVREEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYNRSPDPDRVGGSYMEENENEIDDLLTYFQQQMTVEHSSQKLCQPEVELS-----QVHISALPLEVLMYIFRWVVSCDLDMRALEQLSLV---------------CRGFYICARDPEIWRSACLRVWGRSCTKMLPF--TSWRDMFIERPRVRYDGVYISKTSYIRQGEESLDGFYRKWHQVEYYRYLRFFPDGQVMMLTTPEEP 289
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Sea Lamprey
Match: fbxo9 (F-box protein 9 [Source:NCBI gene;Acc:325469])

HSP 1 Score: 57.3806 bits (137), Expect = 5.912e-9
Identity = 65/247 (26.32%), Postives = 104/247 (42.11%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQI---ETIDRHR--------------QERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNT-VFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDII 968
            E A  ++    E E  G L  A++ YR+A  LV DIE  +         P  +   E ++ +               QE  P+      +  Q+ I  LP E+L+++ RW+V   LDL ++  + +V      C    M   C +  SL  D +IWRL   R+W   +         SW  M   R  L + G    +++   + E   +  V    + + Y+   RF  DG V+M+T+  DPQ I+
Sbjct:   88 EQARELFIRAAELEQEGALYEAIKFYRQAMQLVPDIEFRVNDYGGENGSPGDMDNREAVEDNAVTNLLTSFQSELSLQEAQPKLCRRDTESRQTHISALPVEVLVYVFRWVVSSDLDLRSLEQLSMV------CRGFYM---CAR--SLHRDPEIWRLACLRVWGRNTGKPSPYL--SWRHMFLERTRLRYDGTAPSASTSCFQSEGNKDVFVDCLHISIYYYMYLRFFPDGLVMMLTTPDDPQSIV 321
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO39903 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8N8])

HSP 1 Score: 82.4185 bits (202), Expect = 5.737e-17
Identity = 84/347 (24.21%), Postives = 156/347 (44.96%), Query Frame = 3 
Query:  282 ELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSY---------------NGH------KEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRI------CSVXXXXXXXXXXNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSL 1241
            E A ++++ G   E  G    A+  YR+A  LV DIE  +   ++ L   S  E  +    E   E+++               +GH          + I  +P E++++I +W++  +LD  ++  +  V     AC               A D ++WRL   R+W   +     +++GS+  M   RPH+L  G Y+  T Y+R+GE + N  +    +V Y+R  RF ++GSVV +T+ ++P  +I         PQ+S+     +N S+  G + + GD V + ++ +      C   S   +     P+ E   H   + F+I+ ++R+ +  L W ++ +
Sbjct:   54 EKASKLFQKGVYLERNGKHYDAIMFYRQAMQLVPDIEFKVNTADS-LHGTSDDEEDEEKTSESEDENNFAELASMAGKFHQLSVSGHLCLPEFPPRMTHISVIPVELMVYILKWVISSELDFKSLEQIAAVSRGFYAC---------------ARDPELWRLGCLRVW-GLNTGLPVVWDGSFRLMYIHRPHVLTQGVYISKTMYMRQGEPSVNAFYRSMHVVEYYRYIRFNLNGSVVFLTTNEEPSSVI---------PQLSQ----PSNISLLKGHYRILGDKVVI-VVEVPHTEHQCHGRSRRGKKAAPLPYLENAFH---IEFRIQSTKRKNHGMLTWTTYQI 366
[Close]
BLAST of TPR_REGION domain-containing protein vs. Ensembl Medaka
Match: fbxo9 (F-box protein 9 [Source:NCBI gene;Acc:101174855])

HSP 1 Score: 86.2705 bits (212), Expect = 1.822e-17
Identity = 95/381 (24.93%), Postives = 159/381 (41.73%), Query Frame = 3 
Query:  276 RVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRH-------------RQERAPESSYNG--HKEGQSKILE---LPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWP-DCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXNPF-----EEPIKHRMSMTFQIKRSQRRPNSALRW--RSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSS 1340
            R E A  ++    + E  G +  A++ YR A  LV DIE  I     P    +  + I+ +              Q+   ES +      E ++  L    LP EIL++I RW+V   LD+ T+  + LV               C  F+  A D +IWR    R+W  +C+   L  Y+ SW  M   RP + F G Y+  TSY+R+GE + +  +  +  V Y+R  RF  DG V+M+T+ +DP  ++         P++    +   +  +   + S   D  T     +C         ++ N F         +H   +   +    R+  S L W   S  +++ +  E  +T FD      P   F+RV+ +++
Sbjct:   66 REEKAAELFLRAVQEEQNGAVYEAIKFYRLAMQLVPDIEFKINYSRPPDAERAAGKYIEDNDADGEIEDLFAYFEQQLTMESQFPKICTPENETTPLHISALPREILMYIFRWVVSSDLDMRTLEQLSLV---------------CRGFYICARDPEIWRSACIRVWGRNCT--KLGPYK-SWREMFLQRPRVRFDGVYISKTSYIRQGEESLDGFYRAWHHVEYYRYLRFFPDGQVLMITTPEDPLSVV---------PRLRTRNTRMDSVLVGHFRLSQETDNQTKVFAVVCKKKEEKATEFQRNRFCRRNPASEAEHTFHVGLHLSSRGRQSFSKLVWIHHSCHITYKLTGETVITAFDLDKMYNP-FFFARVKSYTA 418
[Close]
BLAST of TPR_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000032649.1 (SMESG000032649.1)

HSP 1 Score: 730.324 bits (1884), Expect = 0.000e+0
Identity = 384/399 (96.24%), Postives = 384/399 (96.24%), Query Frame = 3 
Query:  150 MAEKLDFMGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRA 1346
            MAEKLDFMGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLV               CHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPFLLVRYFRVFRFRVDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVSSAARRAWRSNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRA
Sbjct:    1 MAEKLDFMGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLV---------------CHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPFLLVRYFRVFRFRVDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVSSAARRAWRSNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRA 384
[Close]
BLAST of TPR_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000032649.1 (SMESG000032649.1)

HSP 1 Score: 716.457 bits (1848), Expect = 0.000e+0
Identity = 377/392 (96.17%), Postives = 377/392 (96.17%), Query Frame = 3 
Query:  171 MGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPXXXXXXXXXXXXXXDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVXXXXXXXXXXNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRA 1346
            MGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLV               CHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPFLLVRYFRVFRFRVDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVSSAARRAWRSNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRA
Sbjct:    1 MGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRIYESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETIDRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVIMGLV---------------CHKFHSLATDEQIWRLISTRLWPDCSVADLDLYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPFLLVRYFRVFRFRVDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASGQFSVNGDMVTVDMIRICSVSSAARRAWRSNPFEEPIKHRMSMTFQIKRSQRRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRA 377
The following BLAST results are available for this feature:
BLAST of TPR_REGION domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
FBXO98.274e-1829.55F-box protein 9 [Source:HGNC Symbol;Acc:HGNC:13588... [more]
FBXO91.955e-1729.55F-box protein 9 [Source:HGNC Symbol;Acc:HGNC:13588... [more]
FBXO92.066e-1729.55F-box protein 9 [Source:HGNC Symbol;Acc:HGNC:13588... [more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CG59613.290e-2125.95gene:FBgn0038056 transcript:FBtr0340187[more]
CG59613.290e-2125.95gene:FBgn0038056 transcript:FBtr0303029[more]
CG59613.290e-2125.95gene:FBgn0038056 transcript:FBtr0082681[more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fbxo91.797e-1627.24F-box protein 9 [Source:NCBI gene;Acc:325469][more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FBXO99.035e-1828.04F-box protein 9 [Source:NCBI gene;Acc:394601][more]
FBXO93.356e-1728.63F-box protein 9 [Source:NCBI gene;Acc:394601][more]
FBXO93.847e-1728.63F-box protein 9 [Source:NCBI gene;Acc:394601][more]
FBXO94.495e-1728.63F-box protein 9 [Source:NCBI gene;Acc:394601][more]
FBXO91.319e-1628.05F-box protein 9 [Source:NCBI gene;Acc:394601][more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Fbxo91.212e-1629.55f-box protein 9 [Source:MGI Symbol;Acc:MGI:1918788... [more]
Fbxo91.346e-1629.55f-box protein 9 [Source:MGI Symbol;Acc:MGI:1918788... [more]
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BLAST of TPR_REGION domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q3ZBT2|FBX9_BOVIN4.033e-1729.55F-box only protein 9 OS=Bos taurus OX=9913 GN=FBXO... [more]
sp|Q9UK97|FBX9_HUMAN9.919e-1729.55F-box only protein 9 OS=Homo sapiens OX=9606 GN=FB... [more]
sp|F6Y9J3|FBX9_XENTR2.381e-1628.63F-box only protein 9 OS=Xenopus tropicalis OX=8364... [more]
sp|Q5U2X1|FBX9_RAT8.354e-1628.34F-box only protein 9 OS=Rattus norvegicus OX=10116... [more]
sp|Q8BK06|FBX9_MOUSE9.417e-1629.55F-box only protein 9 OS=Mus musculus OX=10090 GN=F... [more]
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BLAST of TPR_REGION domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
B0X0N51.813e-2828.90F-box only protein 9 OS=Culex quinquefasciatus OX=... [more]
A0A2T7PGK65.275e-2827.09F-box domain-containing protein OS=Pomacea canalic... [more]
A0A4Y2ERN07.128e-2728.31F-box only protein 9 OS=Araneus ventricosus OX=182... [more]
V3ZU411.227e-2625.55Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
A0A182M1F41.437e-2628.93Uncharacterized protein OS=Anopheles culicifacies ... [more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
fbxo99.089e-1626.95F-box protein 9 [Source:NCBI gene;Acc:103045917][more]
fbxo99.527e-1626.95F-box protein 9 [Source:NCBI gene;Acc:103045917][more]
fbxo91.001e-1526.95F-box protein 9 [Source:NCBI gene;Acc:103045917][more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fbxo95.912e-926.32F-box protein 9 [Source:NCBI gene;Acc:325469][more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO399035.737e-1724.21Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TPR_REGION domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fbxo91.822e-1724.93F-box protein 9 [Source:NCBI gene;Acc:101174855][more]
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BLAST of TPR_REGION domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000032649.10.000e+096.24SMESG000032649.1[more]
SMESG000032649.10.000e+096.17SMESG000032649.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027225 ID=SMED30027225|Name=TPR_REGION domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1920bp
GAAATCTATAGAAATCTTATATGCATAAAACCAATTAACGGATTTTATTT
CAAATATTATGATGATTGTCAGTGCATTATAATTATGCTGATTATATTGG
ATTATATAGTTTACACATAATATTTTCCCATTTATTATTCAATAATTTGA
TGGCAGAGAAACTTGATTTCATGGGATTCCTTAATACAATCGAATCATTG
AGAGAGGAATGGATCAAGGAAATTAATATTAGGAAGCATGAAATAGAAAA
TGGGGAATTGTGTCTGAGTGAGTATAGGGTGGAATTGGCTCACAGGATTT
ATGAAAGTGGCCATGAAGCAGAAATACGTGGATATTTGCAGCTGGCCGTC
GAGCAGTATCGACGAGCGACTTGTCTAGTTCACGACATAGAGAAAATGAT
CAAATTAAGGAACAATCCGTTGAAATTACCGAGTCAAATCGAAACTATTG
ATCGACATCGGCAAGAGAGGGCCCCTGAATCAAGTTACAACGGCCACAAG
GAAGGCCAATCAAAGATATTGGAATTGCCTGATGAAATATTGCTGCATAT
CACGCGGTGGATTGTCGGGGGACAGTTGGATCTGTATACAATTGTAATAA
TGGGTTTGGTGAGATATTTATTGGCTGCGTGCCATCAATTGCTTATGCAT
CAGGTTTGCCACAAGTTTCACTCACTTGCAACTGATGAACAGATCTGGCG
GCTGATCTCGACAAGGCTGTGGCCTGATTGCTCAGTTGCTGACCTAGATC
TGTATGAGGGCTCCTGGATGACAATGGTGAAGACGAGACCGCATTTGCTG
TTCCACGGCTGCTATCTCGGATCTACGAGCTATGTAAGGAAAGGTGAGGC
CACGTTCAACACGGTATTTGCTCCATTCTTGTTGGTGCGGTATTTCCGTG
TGTTCCGATTTCGGGTTGATGGCAGCGTTGTCATGGTAACAAGTGCGCAA
GACCCGCAGGATATCATCCGGCTCATCGGTGACTTGGATCGGACACCGCA
AATATCCAAACTAGAATCGATTGCAGCCAATTACAGCATAGCTAGTGGGC
AATTCTCAGTCAATGGTGACATGGTCACAGTAGATATGATCCGGATATGT
TCCGTCTCTAGTGCTGCACGCCGCGCTTGGAGGTCAAATCCTTTTGAGGA
GCCAATCAAGCATCGCATGTCAATGACGTTCCAGATCAAGCGCTCGCAGC
GCAGGCCCAATTCTGCACTCAGGTGGCGCAGTTTCTCTCTCTCCTTTGTG
GTCAGGAATGAAATGACAGTCACTCATTTCGATTGCAAAGGTGGCAAATT
CCCTACGGTTGTGTTTTCCCGCGTCAGAGAGTTCTCATCCAGGGCCTCAA
TTGGCCATTTATAACATTTGTTGTCTTTGATTGGCTGCATTTTCATTCGG
TTGTGCGATATTGACATAATTGTTTTTGATTGGTTCTCGTTTATCCATTG
TTTGATTGGCTACGTTATTATTACCTTAGTATTACACACATCCAAATAGC
TGCTGGCTTCAAGGACCATAACCGATGTTGAGAGAGATATAATTTGATAT
ATTATATGAATGGGATACGCAATCAAAATGAGCGGTTGTCATTTGTGAAA
TGTAACGGCTCTAACTGCAGGATACGTATCAGTTATTGAGAGGCTGTGCA
GACTGGGGCTATTTGTATTAAATACAAAACCTGGAGATGGTTACTCCTGG
CCATGGTCAATGAGTCATTATGGGGAAATGAATAATTTTGCCTTGCTGCT
GCATAGCTGACTATTGACAAACATTTCCTCATAGTCTGTTAGACAGAAGA
GTGGATTGCAGTGGCGAATTGAAGCATTCAGCTATCGCATATATGCAATG
CCGGATTCAAAATAAATGAACTAAATTATAATTATTTTTTAAGCAATCAT
TTACACGAAACACATGTTAC
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protein sequence of SMED30027225-orf-1

>SMED30027225-orf-1 ID=SMED30027225-orf-1|Name=SMED30027225-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=405bp
MAEKLDFMGFLNTIESLREEWIKEINIRKHEIENGELCLSEYRVELAHRI
YESGHEAEIRGYLQLAVEQYRRATCLVHDIEKMIKLRNNPLKLPSQIETI
DRHRQERAPESSYNGHKEGQSKILELPDEILLHITRWIVGGQLDLYTIVI
MGLVRYLLAACHQLLMHQVCHKFHSLATDEQIWRLISTRLWPDCSVADLD
LYEGSWMTMVKTRPHLLFHGCYLGSTSYVRKGEATFNTVFAPFLLVRYFR
VFRFRVDGSVVMVTSAQDPQDIIRLIGDLDRTPQISKLESIAANYSIASG
QFSVNGDMVTVDMIRICSVSSAARRAWRSNPFEEPIKHRMSMTFQIKRSQ
RRPNSALRWRSFSLSFVVRNEMTVTHFDCKGGKFPTVVFSRVREFSSRAS
IGHL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR036047F-box-like_dom_sf
IPR032675LRR_dom_sf
IPR001810F-box_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0019005SCF ubiquitin ligase complex
Vocabulary: biological process
TermDefinition
GO:0016567protein ubiquitination
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032006regulation of TOR signaling
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001810F-box domainPFAMPF12937F-box-likecoord: 123..189
e-value: 7.3E-7
score: 29.0
NoneNo IPR availablePANTHERPTHR12874:SF9F-BOX ONLY PROTEIN 9coord: 13..394
NoneNo IPR availablePANTHERPTHR12874FAMILY NOT NAMEDcoord: 13..394
IPR036047F-box-like domain superfamilySUPERFAMILYSSF81383F-box domaincoord: 111..215