TPT domain-containing protein

Overview


Name	TPT domain-containing protein
Smed ID	SMED30027187
Length (bp)	510

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of TPT domain-containing protein (SMED30027187) t-SNE clustered cells

Violin plots show distribution of expression levels for TPT domain-containing protein (SMED30027187) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TPT domain-containing protein (SMED30027187) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TPT domain-containing protein (SMED30027187) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027187

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
parenchyma	SMED30027187	SMESG000017437.1	dd_Smed_v4_14231_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Human
Match: SLC35C2 (solute carrier family 35 member C2 [Source:HGNC Symbol;Acc:HGNC:17117])

HSP 1 Score: 77.0258 bits (188), Expect = 1.470e-16
Identity = 63/150 (42.00%), Postives = 92/150 (61.33%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q  +
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQMLLQKAE 191

[Close]

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q  +
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQMLLQKAE 191

[Close]

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q  +
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQMLLQKAE 191

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Human
Match: SLC35C2 (solute carrier family 35 member C2 [Source:HGNC Symbol;Acc:HGNC:17117])

HSP 1 Score: 77.0258 bits (188), Expect = 1.552e-16
Identity = 63/148 (42.57%), Postives = 91/148 (61.49%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q  +
Sbjct:   73 FPLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQMLLQKAE 220

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Celegans
Match: Y47G6A.7 (pep chromosome:WBcel235:I:3502738:3508421:1 gene:WBGene00021637.1 transcript:Y47G6A.7b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y47G6A.7)

HSP 1 Score: 60.077 bits (144), Expect = 5.885e-11
Identity = 56/153 (36.60%), Postives = 83/153 (54.25%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYE-----KYYKTYRKELLWSDFLKISVTGKIDKLVGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            Y  PL +   H  LK++FA + R +YE     +   ++R +L W     I +   +D  +G             YTM KS+SILFI+ FS++L+LE+ R SL F    IA GL +FT+KS+Q  L G +L   A+  +GIRW+ +Q+  Q D 
Sbjct:  105 YKLPLLVVSGHYVLKYLFAITIRFIYECLRTRRTRVSFRDQLRW--LAPIGICASMD--IGLSNWALEYVTVSLYTMAKSSSILFIVAFSLLLRLERWRNSLGFETGLIAAGLFLFTWKSSQLDLTGLMLVELAAACTGIRWTVSQMVMQRDD 253

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Celegans
Match: Y47G6A.7 (pep chromosome:WBcel235:I:3502738:3508421:1 gene:WBGene00021637.1 transcript:Y47G6A.7b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y47G6A.7)

HSP 1 Score: 60.077 bits (144), Expect = 5.885e-11
Identity = 56/153 (36.60%), Postives = 83/153 (54.25%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYE-----KYYKTYRKELLWSDFLKISVTGKIDKLVGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            Y  PL +   H  LK++FA + R +YE     +   ++R +L W     I +   +D  +G             YTM KS+SILFI+ FS++L+LE+ R SL F    IA GL +FT+KS+Q  L G +L   A+  +GIRW+ +Q+  Q D 
Sbjct:  105 YKLPLLVVSGHYVLKYLFAITIRFIYECLRTRRTRVSFRDQLRW--LAPIGICASMD--IGLSNWALEYVTVSLYTMAKSSSILFIVAFSLLLRLERWRNSLGFETGLIAAGLFLFTWKSSQLDLTGLMLVELAAACTGIRWTVSQMVMQRDD 253

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Celegans
Match: Y47G6A.7 (pep chromosome:WBcel235:I:3502738:3508421:1 gene:WBGene00021637.1 transcript:Y47G6A.7a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y47G6A.7)

HSP 1 Score: 60.077 bits (144), Expect = 6.414e-11
Identity = 56/153 (36.60%), Postives = 83/153 (54.25%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYE-----KYYKTYRKELLWSDFLKISVTGKIDKLVGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            Y  PL +   H  LK++FA + R +YE     +   ++R +L W     I +   +D  +G             YTM KS+SILFI+ FS++L+LE+ R SL F    IA GL +FT+KS+Q  L G +L   A+  +GIRW+ +Q+  Q D 
Sbjct:  105 YKLPLLVVSGHYVLKYLFAITIRFIYECLRTRRTRVSFRDQLRW--LAPIGICASMD--IGLSNWALEYVTVSLYTMAKSSSILFIVAFSLLLRLERWRNSLGFETGLIAAGLFLFTWKSSQLDLTGLMLVELAAACTGIRWTVSQMVMQRDD 253

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Celegans
Match: Y47G6A.7 (pep chromosome:WBcel235:I:3502738:3508421:1 gene:WBGene00021637.1 transcript:Y47G6A.7a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y47G6A.7)

HSP 1 Score: 60.077 bits (144), Expect = 6.414e-11
Identity = 56/153 (36.60%), Postives = 83/153 (54.25%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYE-----KYYKTYRKELLWSDFLKISVTGKIDKLVGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            Y  PL +   H  LK++FA + R +YE     +   ++R +L W     I +   +D  +G             YTM KS+SILFI+ FS++L+LE+ R SL F    IA GL +FT+KS+Q  L G +L   A+  +GIRW+ +Q+  Q D 
Sbjct:  105 YKLPLLVVSGHYVLKYLFAITIRFIYECLRTRRTRVSFRDQLRW--LAPIGICASMD--IGLSNWALEYVTVSLYTMAKSSSILFIVAFSLLLRLERWRNSLGFETGLIAAGLFLFTWKSSQLDLTGLMLVELAAACTGIRWTVSQMVMQRDD 253

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Fly
Match: CG14971 (gene:FBgn0035449 transcript:FBtr0073143)

HSP 1 Score: 66.2402 bits (160), Expect = 6.243e-13
Identity = 61/150 (40.67%), Postives = 82/150 (54.67%), Query Frame = 1

Query:  100 PYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 510
            P+PL I   HL +KF+ A + R +Y       R +L W   L K++ TG    + +G+            YTMTKS++I+FIL F+I   LEKK   L+ ++  I  GLLMFTYKST F+  GF   L AS+ SG+RWS  Q   Q  K 
Sbjct:  112 PFPLAIVTYHLVVKFLLAAAARRIYRMRVGRSRVQLDWRLALRKMAPTGVASAIDIGFSNWGLALVPISLYTMTKSSTIVFILLFAIAFGLEKKSWYLVSIVGLIGTGLLMFTYKSTDFNALGFFFILFASLSSGLRWSFAQFIMQKSKL 261

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
Match: slc35c2 (solute carrier family 35 member C2 [Source:ZFIN;Acc:ZDB-GENE-030131-2202])

HSP 1 Score: 68.9366 bits (167), Expect = 1.131e-13
Identity = 59/147 (40.14%), Postives = 86/147 (58.50%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F  +   R   + +    R  L W  +L K++ T     L +G             YTMTKS+++LFILFFS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQL  Q
Sbjct:   39 FHFPLFMTLVHLTIIFCLSTLTRSAMQCWTGKPRVTLPWKVYLSKVAPTALATTLDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLLFKLEEPNPFLILVVVLISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQLLMQ 185

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
Match: slc35c2 (solute carrier family 35 member C2 [Source:ZFIN;Acc:ZDB-GENE-030131-2202])

HSP 1 Score: 68.5514 bits (166), Expect = 1.272e-13
Identity = 59/147 (40.14%), Postives = 86/147 (58.50%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F  +   R   + +    R  L W  +L K++ T     L +G             YTMTKS+++LFILFFS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQL  Q
Sbjct:   39 FHFPLFMTLVHLTIIFCLSTLTRSAMQCWTGKPRVTLPWKVYLSKVAPTALATTLDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLLFKLEEPNPFLILVVVLISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQLLMQ 185

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
Match: slc35c2 (solute carrier family 35 member C2 [Source:ZFIN;Acc:ZDB-GENE-030131-2202])

HSP 1 Score: 68.5514 bits (166), Expect = 1.272e-13
Identity = 59/147 (40.14%), Postives = 86/147 (58.50%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F  +   R   + +    R  L W  +L K++ T     L +G             YTMTKS+++LFILFFS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQL  Q
Sbjct:   39 FHFPLFMTLVHLTIIFCLSTLTRSAMQCWTGKPRVTLPWKVYLSKVAPTALATTLDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLLFKLEEPNPFLILVVVLISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQLLMQ 185

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
Match: slc35c2 (solute carrier family 35 member C2 [Source:ZFIN;Acc:ZDB-GENE-030131-2202])

HSP 1 Score: 62.003 bits (149), Expect = 5.097e-12
Identity = 59/145 (40.69%), Postives = 85/145 (58.62%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            +PL +T+ HL + F  +   R   + +    R  L W  +L K++ T     L +G             YTMTKS+++LFILFFS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQL  Q
Sbjct:   41 FPLFMTLVHLTIIFCLSTLTRSAMQCWTGKPRVTLPWKVYLSKVAPTALATTLDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLLFKLEEPNPFLILVVVLISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQLLMQ 185

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
Match: slc35c2 (solute carrier family 35 member C2 [Source:ZFIN;Acc:ZDB-GENE-030131-2202])

HSP 1 Score: 62.7734 bits (151), Expect = 1.199e-11
Identity = 59/149 (39.60%), Postives = 86/149 (57.72%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 510
            +PL +T+ HL + F  +   R   + +    R  L W  +L K++ T     L +G             YTMTKS+++LFILFFS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQL  Q  + 
Sbjct:   41 FPLFMTLVHLTIIFCLSTLTRSAMQCWTGKPRVTLPWKVYLSKVAPTALATTLDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLLFKLEEPNPFLILVVVLISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQLLMQKAEL 189

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000029795.1 (solute carrier family 35 member C2-like [Source:NCBI gene;Acc:101731373])

HSP 1 Score: 64.3142 bits (155), Expect = 2.198e-12
Identity = 46/81 (56.79%), Postives = 62/81 (76.54%), Query Frame = 1

Query:  265 YRYTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            +RYTMTKS+++LFILFFS++ KLE+ R  LI V+L I+ GL MFT+KSTQF+  GF+L L+AS   G+RW+ TQL  Q  +
Sbjct:   21 FRYTMTKSSAVLFILFFSLVFKLEQMRPGLILVVLLISGGLFMFTFKSTQFNTGGFVLVLAASAFGGVRWTLTQLLMQKAE 101

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Mouse
Match: Slc35c2 (solute carrier family 35, member C2 [Source:MGI Symbol;Acc:MGI:2385166])

HSP 1 Score: 76.2554 bits (186), Expect = 2.961e-17
Identity = 63/147 (42.86%), Postives = 91/147 (61.90%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQILLQ 188

[Close]

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQILLQ 188

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Mouse
Match: Slc35c2 (solute carrier family 35, member C2 [Source:MGI Symbol;Acc:MGI:2385166])

HSP 1 Score: 76.6406 bits (187), Expect = 1.599e-16
Identity = 63/147 (42.86%), Postives = 91/147 (61.90%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQILLQ 188

[Close]

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQILLQ 188

[Close]

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQILLQ 188

[Close]

BLAST of TPT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9NQQ7|S35C2_HUMAN (Solute carrier family 35 member C2 OS=Homo sapiens OX=9606 GN=SLC35C2 PE=1 SV=2)

HSP 1 Score: 77.0258 bits (188), Expect = 7.058e-16
Identity = 63/150 (42.00%), Postives = 92/150 (61.33%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q  +
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSNWSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQMLLQKAE 191

[Close]

BLAST of TPT domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8VCX2|S35C2_MOUSE (Solute carrier family 35 member C2 OS=Mus musculus OX=10090 GN=Slc35c2 PE=1 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 1.118e-15
Identity = 63/147 (42.86%), Postives = 91/147 (61.90%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F+F+   R + +      R  L W+D+L+ ++ T     L VG             YTMTKS+++LFIL FS+I KLE+ R +L+ V+L IA GL MFTYKSTQF+++GF L L AS + GIRW+ TQ+  Q
Sbjct:   42 FHFPLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRWTLTQILLQ 188

[Close]

BLAST of TPT domain-containing protein vs. TrEMBL
Match: A0A0H3YKF8 (Slc35c-4 OS=Schmidtea mediterranea OX=79327 GN=slc35c-4 PE=2 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 9.345e-29
Identity = 56/56 (100.00%), Postives = 56/56 (100.00%), Query Frame = 1

Query:  343 RISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 510
            RISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF
Sbjct:   23 RISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 78

[Close]

BLAST of TPT domain-containing protein vs. TrEMBL
Match: A0A1I8GSZ4 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 1.482e-26
Identity = 77/147 (52.38%), Postives = 98/147 (66.67%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            YPYPL+ITV HL +KF+ AW  R V E+    +R EL W+ + + +S  G    L +G             YTMTKST+++FIL F+I L+LE+KR SL+ VIL IA GL +FTYKSTQFH  GFLL LSAS +SGIRW+T Q+ TQ
Sbjct:   57 YPYPLSITVLHLCVKFLLAWLIRQVVEQLTGCHRLELCWAAYCRRVSPAGIASSLDIGLSNWSFEFVTVSLYTMTKSTAVVFILLFAIYLRLEEKRWSLVLVILLIAVGLFLFTYKSTQFHTGGFLLVLSASFVSGIRWTTAQVVTQ 203

[Close]

BLAST of TPT domain-containing protein vs. TrEMBL
Match: A0A0H3YFJ8 (Slc35c-3 OS=Schmidtea mediterranea OX=79327 GN=slc35c-3 PE=2 SV=1)

HSP 1 Score: 108.227 bits (269), Expect = 7.710e-25
Identity = 79/150 (52.67%), Postives = 101/150 (67.33%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSD-FLKISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            YPYPL+IT+ HL +KF+ A   R +   + K  R EL W D F KIS +G    L +G             YTMTKSTSI+FIL F+I+ KLEKK +S++F++LFIA GL MFTYKSTQF++ GF+LCL AS +SGIRW+T QL TQ  +
Sbjct:   40 YPYPLSITMLHLIVKFLLASFVRGILRIFSKHDRTELCWKDYFRKISPSGITSSLDIGLSNWSFEFITVSLYTMTKSTSIIFILIFAIVFKLEKKGLSIVFIVLFIAGGLFMFTYKSTQFNMDGFMLCLLASFISGIRWTTAQLVTQKSE 189

[Close]

BLAST of TPT domain-containing protein vs. TrEMBL
Match: A0A267DSM9 (TPT domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig005048g1 PE=4 SV=1)

HSP 1 Score: 107.457 bits (267), Expect = 7.802e-25
Identity = 77/151 (50.99%), Postives = 99/151 (65.56%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 510
            YPYPL+ITV HL +KF+ AW  R V E+    +R EL W+ + + +S  G    L +G             YTMTKST+++FIL F+I L+LE+KR SL+ VIL IA GL +FTYKSTQFH  GFLL LSAS +SGIRW+T Q+ TQ  + 
Sbjct:   57 YPYPLSITVLHLCVKFLLAWLIRQVVEQLTGCHRLELCWAAYCRRVSPAGIASSLDIGLSNWSFEFVTVSLYTMTKSTAVVFILLFAIYLRLEEKRWSLVLVILLIAVGLFLFTYKSTQFHTGGFLLVLSASFVSGIRWTTAQVVTQRAEL 207

[Close]

BLAST of TPT domain-containing protein vs. TrEMBL
Match: A0A267FRD8 (TPT domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig005048g6 PE=4 SV=1)

HSP 1 Score: 107.842 bits (268), Expect = 7.827e-25
Identity = 77/151 (50.99%), Postives = 99/151 (65.56%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK-ISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 510
            YPYPL+ITV HL +KF+ AW  R V E+    +R EL W+ + + +S  G    L +G             YTMTKST+++FIL F+I L+LE+KR SL+ VIL IA GL +FTYKSTQFH  GFLL LSAS +SGIRW+T Q+ TQ  + 
Sbjct:   57 YPYPLSITVLHLCVKFLLAWLIRQVVEQLTGCHRLELCWAAYCRRVSPAGIASSLDIGLSNWSFEFVTVSLYTMTKSTAVVFILLFAIYLRLEEKRWSLVLVILLIAVGLFLFTYKSTQFHTGGFLLVLSASFVSGIRWTTAQVVTQRAEL 207

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000013197.2 (pep primary_assembly:Astyanax_mexicanus-2.0:15:25809036:25860556:1 gene:ENSAMXG00000012384.2 transcript:ENSAMXT00000013197.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 77.7962 bits (190), Expect = 7.088e-17
Identity = 58/147 (39.46%), Postives = 88/147 (59.86%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQ 498
            + +PL +T+ HL + F  +   RC  + + +  R  L W ++L K++ T     L +G             YTMTKS+++LFIL FS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQ+  Q
Sbjct:   39 FHFPLFMTLVHLVIIFCLSALTRCAMQCWTRKPRVTLGWKEYLYKVAPTALATALDIGLSNWSFLFITISLYTMTKSSAVLFILLFSLVFKLEEPNPFLILVVILISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQVLMQ 185

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000044703.1 (pep primary_assembly:Astyanax_mexicanus-2.0:15:25808986:25818566:1 gene:ENSAMXG00000012384.2 transcript:ENSAMXT00000044703.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 69.3218 bits (168), Expect = 4.835e-14
Identity = 58/148 (39.19%), Postives = 88/148 (59.46%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFL-KISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            +PL +T+ HL + F  +   RC  + + +  R  L W ++L K++ T     L +G             YTMTKS+++LFIL FS++ KLE+    LI V++ I+ GL MFT KSTQF+L+GF++ L AS + GIRW+ TQ+  Q  +
Sbjct:   41 FPLFMTLVHLVIIFCLSALTRCAMQCWTRKPRVTLGWKEYLYKVAPTALATALDIGLSNWSFLFITISLYTMTKSSAVLFILLFSLVFKLEEPNPFLILVVILISSGLFMFTLKSTQFNLEGFIMVLLASFIGGIRWTLTQVLMQKAE 188

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Sea Lamprey
Match: slc35c2 (solute carrier family 35 member C2 [Source:ZFIN;Acc:ZDB-GENE-030131-2202])

HSP 1 Score: 84.3445 bits (207), Expect = 2.283e-20
Identity = 65/150 (43.33%), Postives = 94/150 (62.67%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK----ISVTGKIDKLVGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            +PL +T+ H+ + F+F+   R + +   +  R  L W ++LK     ++   +D  +G             YTMTKSTSI+FIL FSI+ +LEK R SLI V++ IA GL MFTY+STQF+L+GFLL L+AS + GIRW+ TQ+ TQ  +
Sbjct:   42 FPLAMTMVHMAMNFMFSALVRAMMQCAGERERVALPWPEYLKRVGPTAIASALD--IGLSNWSFLFITISLYTMTKSTSIIFILLFSIVFRLEKARPSLIVVVILIAGGLFMFTYESTQFNLEGFLLVLTASFIGGIRWTLTQILTQKAE 189

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Nematostella
Match: EDO40549 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S701])

HSP 1 Score: 80.8777 bits (198), Expect = 1.244e-18
Identity = 62/152 (40.79%), Postives = 93/152 (61.18%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLK----ISVTGKIDKLVGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            + +PL+++V H  + FI +   R  +E +    R  L WS +++     +V   +D  +G             YTMTKSTSI+FI+  +++ +LEK R SL+ ++L IA GL MFTY+STQF+ +GFL+CL+AS LSGIRW+ TQ+  Q D 
Sbjct:   41 FHFPLSVSVVHYCMVFIISAILRRAWEFHKGKKRIILSWSIYIRRVLPTAVASALD--IGLSNWSFMFITVSLYTMTKSTSIIFIMICALLFRLEKWRPSLLVIVLLIAGGLFMFTYQSTQFNAEGFLICLTASGLSGIRWTLTQMIMQKDS 190

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Medaka
Match: slc35c2 (solute carrier family 35 member C2 [Source:NCBI gene;Acc:101157129])

HSP 1 Score: 60.077 bits (144), Expect = 8.952e-11
Identity = 57/148 (38.51%), Postives = 87/148 (58.78%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSD-FLKISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            +P+ +T+ HL + F  +   R + + +    R  L W+  F K++ T     L +G             YTMTKS+++LFILFFS+I KLE+    LI V+L I+ GL MFT+ STQF+++GF++ L A+ + GIRW+ TQL  Q  +
Sbjct:   41 FPIFMTLVHLAVIFGLSALTRSILQLWTGKPRVVLKWAVYFRKVAPTAMATALDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLIFKLEEPNPFLILVVLLISTGLFMFTFHSTQFNMEGFVMVLLAAFIGGIRWTLTQLLMQKAE 188

[Close]

BLAST of TPT domain-containing protein vs. Ensembl Medaka
Match: slc35c2 (solute carrier family 35 member C2 [Source:NCBI gene;Acc:101157129])

HSP 1 Score: 59.6918 bits (143), Expect = 9.553e-11
Identity = 57/148 (38.51%), Postives = 87/148 (58.78%), Query Frame = 1

Query:  103 YPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSD-FLKISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDK 507
            +P+ +T+ HL + F  +   R + + +    R  L W+  F K++ T     L +G             YTMTKS+++LFILFFS+I KLE+    LI V+L I+ GL MFT+ STQF+++GF++ L A+ + GIRW+ TQL  Q  +
Sbjct:   41 FPIFMTLVHLAVIFGLSALTRSILQLWTGKPRVVLKWAVYFRKVAPTAMATALDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLIFKLEEPNPFLILVVLLISTGLFMFTFHSTQFNMEGFVMVLLAAFIGGIRWTLTQLLMQKAE 188

[Close]

BLAST of TPT domain-containing protein vs. Planmine SMEST
Match: SMESG000017437.1 (SMESG000017437.1)

HSP 1 Score: 206.453 bits (524), Expect = 1.788e-66
Identity = 151/193 (78.24%), Postives = 154/193 (79.79%), Query Frame = 1

Query:   28 FKKLWTKCXXXXXXXXXXXX--------------------XXXYPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLKISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 510
            F+KLWTKCTVLNLTTTFLNV                     +LYPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLKISVTG    L +G             YTMTKSTSILFILFFSIILKLEKKRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF
Sbjct:    2 FQKLWTKCTVLNLTTTFLNVFIVILYFFFSIRLTFYNKKYIVLYPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSDFLKISVTGLTSSLDIGLSNWSFEYITISLYTMTKSTSILFILFFSIILKLEKKRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIRWSTTQLFTQHDKF 194

[Close]

BLAST of TPT domain-containing protein vs. Planmine SMEST
Match: SMESG000055160.1 (SMESG000055160.1)

HSP 1 Score: 94.7449 bits (234), Expect = 1.941e-23
Identity = 73/138 (52.90%), Postives = 93/138 (67.39%), Query Frame = 1

Query:   97 YPYPLTITVTHLFLKFIFAWSFRCVYEKYYKTYRKELLWSD-FLKISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIR 471
            YPYPL+IT+ HL +KF+ A   R +   + K  R EL W D F KIS +G    L +G             YTMTKSTSI+FIL F+I+ KLEKK +S++F++LFIA GL MFTYKSTQF++ GF+LCL AS +SGIR
Sbjct:   40 YPYPLSITMLHLIVKFLLASFVRVILRIFSKHDRTELCWKDYFRKISPSGITSSLDIGLSNWSFEFITVSLYTMTKSTSIIFILIFAIVFKLEKKGLSIVFIVLFIAGGLFMFTYKSTQFNMDGFMLCLLASFISGIR 177

[Close]

BLAST of TPT domain-containing protein vs. Planmine SMEST
Match: SMESG000055160.1 (SMESG000055160.1)

HSP 1 Score: 78.1814 bits (191), Expect = 1.635e-17
Identity = 66/128 (51.56%), Postives = 84/128 (65.62%), Query Frame = 1

Query:  127 HLFLKFIFAWSFRCVYEKYYKTYRKELLWSD-FLKISVTGKIDKL-VGYR-----------YTMTXXXXXXXXXXXXXXXXXXXXRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSASMLSGIR 471
            HL +KF+ A   R +   + K  R EL W D F KIS +G    L +G             YTMTKSTSI+FIL F+I+ KLEKK +S++F++LFIA GL MFTYKSTQF++ GF+LCL AS +SGIR
Sbjct:    3 HLIVKFLLASFVRVILRIFSKHDRTELCWKDYFRKISPSGITSSLDIGLSNWSFEFITVSLYTMTKSTSIIFILIFAIVFKLEKKGLSIVFIVLFIAGGLFMFTYKSTQFNMDGFMLCLLASFISGIR 130

The following BLAST results are available for this feature:

BLAST of TPT domain-containing protein vs. Ensembl Human
BLAST of TPT domain-containing protein vs. Ensembl Celegans
BLAST of TPT domain-containing protein vs. Ensembl Fly
BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
BLAST of TPT domain-containing protein vs. Ensembl Xenopus
BLAST of TPT domain-containing protein vs. Ensembl Mouse
BLAST of TPT domain-containing protein vs. UniProt/SwissProt
BLAST of TPT domain-containing protein vs. TrEMBL
BLAST of TPT domain-containing protein vs. Ensembl Cavefish
BLAST of TPT domain-containing protein vs. Ensembl Sea Lamprey
BLAST of TPT domain-containing protein vs. Ensembl Yeast
BLAST of TPT domain-containing protein vs. Ensembl Nematostella
BLAST of TPT domain-containing protein vs. Ensembl Medaka
BLAST of TPT domain-containing protein vs. Planmine SMEST

BLAST of TPT domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
SLC35C2	1.470e-16	42.00	solute carrier family 35 member C2 [Source:HGNC Sy...	[more]
SLC35C2	1.470e-16	42.00	solute carrier family 35 member C2 [Source:HGNC Sy...	[more]
SLC35C2	1.470e-16	42.00	solute carrier family 35 member C2 [Source:HGNC Sy...	[more]
SLC35C2	1.552e-16	42.57	solute carrier family 35 member C2 [Source:HGNC Sy...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Y47G6A.7	5.885e-11	36.60	pep chromosome:WBcel235:I:3502738:3508421:1 gene:W...	[more]
Y47G6A.7	5.885e-11	36.60	pep chromosome:WBcel235:I:3502738:3508421:1 gene:W...	[more]
Y47G6A.7	6.414e-11	36.60	pep chromosome:WBcel235:I:3502738:3508421:1 gene:W...	[more]
Y47G6A.7	6.414e-11	36.60	pep chromosome:WBcel235:I:3502738:3508421:1 gene:W...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CG14971	6.243e-13	40.67	gene:FBgn0035449 transcript:FBtr0073143	[more]

BLAST of TPT domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
slc35c2	1.131e-13	40.14	solute carrier family 35 member C2 [Source:ZFIN;Ac...	[more]
slc35c2	1.272e-13	40.14	solute carrier family 35 member C2 [Source:ZFIN;Ac...	[more]
slc35c2	1.272e-13	40.14	solute carrier family 35 member C2 [Source:ZFIN;Ac...	[more]
slc35c2	5.097e-12	40.69	solute carrier family 35 member C2 [Source:ZFIN;Ac...	[more]
slc35c2	1.199e-11	39.60	solute carrier family 35 member C2 [Source:ZFIN;Ac...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSXETT00000029795.1	2.198e-12	56.79	solute carrier family 35 member C2-like [Source:NC...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Slc35c2	2.961e-17	42.86	solute carrier family 35, member C2 [Source:MGI Sy...	[more]
Slc35c2	2.961e-17	42.86	solute carrier family 35, member C2 [Source:MGI Sy...	[more]
Slc35c2	1.599e-16	42.86	solute carrier family 35, member C2 [Source:MGI Sy...	[more]
Slc35c2	1.599e-16	42.86	solute carrier family 35, member C2 [Source:MGI Sy...	[more]
Slc35c2	1.599e-16	42.86	solute carrier family 35, member C2 [Source:MGI Sy...	[more]

BLAST of TPT domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2


Match Name	E-value	Identity	Description
sp\|Q9NQQ7\|S35C2_HUMAN	7.058e-16	42.00	Solute carrier family 35 member C2 OS=Homo sapiens...	[more]
sp\|Q8VCX2\|S35C2_MOUSE	1.118e-15	42.86	Solute carrier family 35 member C2 OS=Mus musculus...	[more]

BLAST of TPT domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0H3YKF8	9.345e-29	100.00	Slc35c-4 OS=Schmidtea mediterranea OX=79327 GN=slc...	[more]
A0A1I8GSZ4	1.482e-26	52.38	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A0H3YFJ8	7.710e-25	52.67	Slc35c-3 OS=Schmidtea mediterranea OX=79327 GN=slc...	[more]
A0A267DSM9	7.802e-25	50.99	TPT domain-containing protein OS=Macrostomum ligna...	[more]
A0A267FRD8	7.827e-25	50.99	TPT domain-containing protein OS=Macrostomum ligna...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSAMXT00000013197.2	7.088e-17	39.46	pep primary_assembly:Astyanax_mexicanus-2.0:15:258...	[more]
ENSAMXT00000044703.1	4.835e-14	39.19	pep primary_assembly:Astyanax_mexicanus-2.0:15:258...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
slc35c2	2.283e-20	43.33	solute carrier family 35 member C2 [Source:ZFIN;Ac...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of TPT domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO40549	1.244e-18	40.79	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of TPT domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
slc35c2	8.952e-11	38.51	solute carrier family 35 member C2 [Source:NCBI ge...	[more]
slc35c2	9.553e-11	38.51	solute carrier family 35 member C2 [Source:NCBI ge...	[more]

BLAST of TPT domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000017437.1	1.788e-66	78.24	SMESG000017437.1	[more]
SMESG000055160.1	1.941e-23	52.90	SMESG000055160.1	[more]
SMESG000055160.1	1.635e-17	51.56	SMESG000055160.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027187 ID=SMED30027187|Name=TPT domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=510bp
ATTGATCATATTTTTGAATTAATTACTTTTAAAAAACTATGGACGAAGTG
CACTGTATTGAATTTAACCACAACATTTTTAAATGTGTTTATTTTGTATC
CTTATCCATTGACAATAACTGTCACTCATTTATTTTTAAAGTTTATTTTT
GCATGGAGTTTTCGATGTGTTTATGAAAAGTATTACAAAACCTATCGAAA
GGAATTATTGTGGAGTGACTTTTTGAAAATATCTGTTACAGGCAAGATTG
ACAAGCTCGTTGGATATCGGTACACAATGACTAAATCAACTAGTATTTTA
TTTATTTTGTTTTTTTCCATAATTTTGAAGCTCGAAAAAAAAAGAATTTC
TTTAATATTTGTCATTTTATTCATTGCCTGTGGACTTTTGATGTTTACTT
ACAAATCGACTCAGTTCCATTTGCAAGGCTTTCTCTTGTGCCTGTCAGCC
TCTATGCTCAGCGGGATCAGGTGGTCCACCACGCAATTATTCACCCAGCA
TGACAAATTC

protein sequence of SMED30027187-orf-1

>SMED30027187-orf-1 ID=SMED30027187-orf-1|Name=SMED30027187-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=170bp
IDHIFELITFKKLWTKCTVLNLTTTFLNVFILYPYPLTITVTHLFLKFIF
AWSFRCVYEKYYKTYRKELLWSDFLKISVTGKIDKLVGYRYTMTKSTSIL
FILFFSIILKLEKKRISLIFVILFIACGLLMFTYKSTQFHLQGFLLCLSA
SMLSGIRWSTTQLFTQHDKF

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PANTHER	PTHR11132:SF238	SOLUTE CARRIER FAMILY 35 MEMBER C2	coord: 91..167
None	No IPR available	PANTHER	PTHR11132	SOLUTE CARRIER FAMILY 35	coord: 91..167
None	No IPR available	TMHMM	TMhelix		coord: 87..109
None	No IPR available	TMHMM	TMhelix		coord: 116..134
None	No IPR available	TMHMM	TMhelix		coord: 20..42
None	No IPR available	TMHMM	TMhelix		coord: 139..161

Main menu

TPT domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Owlery

blazegraph-runner