Multidrug resistance-associated protein 1

Overview


Name	Multidrug resistance-associated protein 1
Smed ID	SMED30027178
Length (bp)	5109

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Multidrug resistance-associated protein 1 (SMED30027178) t-SNE clustered cells

Violin plots show distribution of expression levels for Multidrug resistance-associated protein 1 (SMED30027178) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Multidrug resistance-associated protein 1 (SMED30027178) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027178

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	dd_Smed_v4_9208_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	dd_Smed_v4_9208_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	dd_Smed_v4_9208_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	dd_Smed_v4_9208_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	dd_Smed_v4_9208_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
pigment cell	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	SMED30027178	smed_20140614	PMID:22884275 Lapan et al., 2012
enteric muscle cell	SMED30027178	SMESG000000275.1 SMESG000000273.1 SMESG000000262.1 SMESG000000250.1 SMESG000000247.1 SMESG000000245.1	dd_Smed_v4_9208_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018

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Homology

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC2 (ATP binding cassette subfamily C member 2 [Source:HGNC Symbol;Acc:HGNC:53])

HSP 1 Score: 997.653 bits (2578), Expect = 0.000e+0
Identity = 576/1444 (39.89%), Postives = 871/1444 (60.32%), Query Frame = 3

Query:  690 ASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLL--------QNSTASVAHL----MEDEDKLTNPDNRS-----------PGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPS---GGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGL----WLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVV--CFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNN 4925
            AS LS +TYSW D+ I K +++ +T E   D+   DE  K   ++ K F   +K    + R  L         QNS A +  L     + +D L   D              P   L  +L + + + LL +   K V+D   +  P LLK+L+ +  +R    WIGY  AI      ++ S      F +   L +++R A++  +Y+K L L+N  R ++T GE VNLMSVDA+++M+   F     S  LQIVL+I  L++E+  ++ AG+G++V   P+N +L    +      +K KD R+KI+ EIL+GIK+LK +AWE SF D++ NLR  E++ +L  S    VV  ++++ P L+ + TF  YVL    NI+  +KAF S+TLFN+LRFP+ +LP  ++  + A VS +R+ +YL G++L+ + I H         N+D A++  + SF+W+ + + T+ ++N +I  G+LVA++G VG+GKSSLISA+LGEM  ++G ++++GT AYV Q++WIQN ++K+NILF  ++NEK Y+ ++EAC+L  DLE LPGGD  EIGE+GINLSGGQKQR+SLARA YQN DIYLLDDPLSAVDAHVG+H+F  V+  NG+LK KTR+LVTH +++LP+VDE++VL  NG+I E+GS+  LL    EF + ++ ++ H    +  +   G +   D+  L         +S  E++ E+     +       +       SN                 RH+K   NS              + T    S +  +E  +           +L+++E   +G VK++ Y   +++ GL    ++ +A V    AF G    SN+WL  +T DS I N++ +        P   + +R      + +Y  +GL   + V    +W++F  G ++AS ++HK+LL ++LR+PM FFDTTP+GRI+NRF+ DI  +D  +P ++   ++C   + +++++I   TP F I +IPL I+Y  +Q+FY+ TSRQ RRLDS+  SP+++HF+ET+ G+ +IRAF+ QQ F   N+  ID + K  F   +S RWL++R+E++G L VF + L  +I R +L+   VG  +S +L IT+ LNWL+R  +E+ETN VA+ERI EY+K+ +EA W  +  P   WP+ G I F +Y +RYR  L LVL+ I       +KIGVVGRTGAGKSSL   LFR++EAAGG IIID ++I++IGLHDLR++LTI+PQDP++FSG+LR NLDPF+++ D+EI+++LE AHL+S+V+ L  GL +E  E G NLS+                      GQ+QLLCL RALLRKSK+L+LDEATA+VD+ETD L+  TI+  F   TVI IAHR++TI+D+D ++V++NG+I+E  SP+ LL +    +    +  + N
Sbjct:  198 ASFLSSITYSWYDSIILKGYKRPLTLE---DVWEVDEEMKTKTLVSK-FETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHD-------CNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVL-GNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGL---------ISSVEEIPEDAASITMRRENSFRRTLSRSSRSNG----------------RHLKSLRNS--------------LKTRNVNSLKEDEELVKG---------QKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIG----SNLWLSAWTSDSKIFNSTDY--------PASQRDMR------VGVYGALGLAQGIFVFIAHFWSAF--GFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSI----------------------GQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIEN 1539

HSP 2 Score: 87.0409 bits (214), Expect = 2.874e-16
Identity = 72/251 (28.69%), Postives = 119/251 (47.41%), Query Frame = 3

Query: 1965 AAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEY-IEHNNRAK 2675
              I+  +    ++ E  L L  I  +IG  + + +VG+ G GKSSL + +   +    G + + G              +  + Q+  + + SL+ N+    +Y+++     +E   LKS +  L  G   E+ E G NLS GQ+Q + L RA+ +   I +LD+  +AVD     +L +  I N       T I + H L+ +   D+V+VLD NG I E GS ++LL+    F    +E  IE+ N  K
Sbjct: 1298 GKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLET-DNLIQTTIQNE--FAHCTVITIAHRLHTIMDSDKVMVLD-NGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTK 1544

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC3 (ATP binding cassette subfamily C member 3 [Source:HGNC Symbol;Acc:HGNC:54])

HSP 1 Score: 990.719 bits (2560), Expect = 0.000e+0
Identity = 583/1523 (38.28%), Postives = 893/1523 (58.63%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLT-HCF---SSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDE-SALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++ ++ +++ +T++LA L  +  R        +L IFW    +  ++     I  LL  +   I +   F +  I F  +++ L   CF     F   + V PN  P PE  A  LS+L + W        +R  + ++  + L+ +D S      L + +  + K +   K       ++A+       ED++     P  R P ++   +L   +G   L++  FK + D   +  P LL IL+ +I N     W G+ +A       ++ SL     +    +  ++ R  ++G+IYRK L + N ++   T GEIVNLMSVDA+R M+   F     S PLQI+LAI  L+Q +  ++ AG+  +V   PLNG +   M+ F   ++K KD RIK+++EILNGIKVLK+YAWE SFL ++  +R  E++ +LR +A         W   PFL+ L T   YV     N++  EKAFVS++LFN+LR P+ +LP  +++   A VSLKRI Q+L  EEL+   +  +  +   A      I I  G+F+W ++   TL++++ ++ +G LVA+VG VG GKSSL+SA+LGEM ++ G V ++G++AYV Q+AWIQN +L+EN+LF +  N K Y+  +EAC+L +DLE LPGGD+TEIGE+GINLSGGQ+QRVSLARAVY + DI+LLDDPLSAVD+HV +H+F++VI   G+L  KTR+LVTHG+++LP+ D ++VL ++G +SE G +  LL+    F  F+  Y    ++        HL D  +AL  A++  ++    ED +   TD     P   + +    R  +A                        S+ G  E +    PR     S+  Q+++           K    L +EE+A  GTV+ + +    K+ GL   +A   +Y   +   + +N+WL  +T D+ + ++ Q+                  T   + +Y  +G+    +V     +   G I A++V+H+ LL + +RSP  FFDTTPSGRI+N FSKDI  +D ++   I   L+  F   ++++VI+  TP F + I+PLA+LY L+Q FY  TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+   + F+ ++ T +D + +  +    S RWLS+ +E +G  +V  A LF++IGR SL   LVGLS+SYSLQ+T  LNW++R  ++LE+N VA+ER++EYSK  +EA W +  + P + WP  G + F++Y +RYR GL LVL++++LH HGG+K+G+VGRTGAGKSS+ L LFR++EAA G I ID +N++ IGLHDLR +LTI+PQDP++FSGTLR NLDPF S+ +++I+ +LE +HL ++VS    GLD++C EGG NLSV                      GQ+QL+CLARALLRKS++L+LDEATA++D+ETD L+  TIR  F   TV+ IAHR+NTI+D   ++V++ G + E DSP NL+A + GIF  +
Sbjct:  104 VFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKI--LLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPN--PYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHK-------ASAAPGKNASGEDEVLLGARPRPRKPSFLK--ALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQ-LLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYA------ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-ADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQG-------HLEDSWTALEGAED--KEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSAL-----------------------SSDG--EGQGRPVPRRHLGPSEKVQVTEA----------KADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDA-MADSRQN-----------------NTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV----------------------GQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA-ARGIFYGM 1520

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC3 (ATP binding cassette subfamily C member 3 [Source:HGNC Symbol;Acc:HGNC:54])

HSP 1 Score: 631.328 bits (1627), Expect = 0.000e+0
Identity = 400/1159 (34.51%), Postives = 634/1159 (54.70%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLT-HCF---SSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDE-SALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLID 3815
            ++ ++ +++ +T++LA L  +  R        +L IFW    +  ++     I  LL  +   I +   F +  I F  +++ L   CF     F   + V PN  P PE  A  LS+L + W        +R  + ++  + L+ +D S      L + +  + K +   K       ++A+       ED++     P  R P ++   +L   +G   L++  FK + D   +  P LL IL+ +I N     W G+ +A       ++ SL     +    +  ++ R  ++G+IYRK L + N ++   T GEIVNLMSVDA+R M+   F     S PLQI+LAI  L+Q +  ++ AG+  +V   PLNG +   M+ F   ++K KD RIK+++EILNGIKVLK+YAWE SFL ++  +R  E++ +LR +A         W   PFL+ L T   YV     N++  EKAFVS++LFN+LR P+ +LP  +++   A VSLKRI Q+L  EEL+   +  +  +   A      I I  G+F+W ++   TL++++ ++ +G LVA+VG VG GKSSL+SA+LGEM ++ G V ++G++AYV Q+AWIQN +L+EN+LF +  N K Y+  +EAC+L +DLE LPGGD+TEIGE+GINLSGGQ+QRVSLARAVY + DI+LLDDPLSAVD+HV +H+F++VI   G+L  KTR+LVTHG+++LP+ D ++VL ++G +SE G +  LL+    F  F+  Y    ++        HL D  +AL  A++  ++    ED +   TD     P   + +    R  +A                        S+ G  E +    PR     S+  Q+   T+   D         L +EE+A  GTV+ + +    K+ GL   +A   +Y   +   + +N+WL  +T D+ + ++ Q+                  T   + +Y  +G+    +V     +   G I A++V+H+ LL + +RSP  FFDTTPSGRI+N FSKDI  +D ++   I   L+  F   ++++VI+  TP F + I+PLA+LY L+Q FY  TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+   + F+ ++ T +D
Sbjct:  104 VFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKI--LLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPN--PYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHK-------ASAAPGKNASGEDEVLLGARPRPRKPSFL--KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQ-LLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYA------ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-ADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQG-------HLEDSWTALEGAED--KEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSAL-----------------------SSDG--EGQGRPVPRRHLGPSEKVQV---TEAKAD-------GALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDA-MADSRQN-----------------NTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVD 1179

HSP 2 Score: 82.8037 bits (203), Expect = 5.744e-15
Identity = 76/303 (25.08%), Postives = 130/303 (42.90%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            LN L +  + L    V+L+RI+++    S+ E D  +    +      IT       + + LP  L ++++    G  + VVG  G GKSSL  AL   +E   G +              ++  +  +PQ   I + TL+EN+    +       Q+LE   L + +  L  G   E GE G+NLS                       GQ+Q + LARA+   + + +LD+  ++VD    + +  H I         T +++ H I+ +  TD I+V+ +G++ E+  P   L   +G F
Sbjct:  582 LNMLPQLISNLTQASVSLKRIQQFL---SQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKV-------------HMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLS----------------------GGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEM-GPYPALLQRNGSF 845

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51])

HSP 1 Score: 557.755 bits (1436), Expect = 7.511e-171
Identity = 320/799 (40.05%), Postives = 466/799 (58.32%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLL--DASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFS---KDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDN-----RSPG--W--VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALG 2720
            ++++S  +L IT++LA    ++ RR       I+  FWL A +  L  L   I+  L  DA     R+         F L L+  +  CFS  S    + +  PN  PCPE  AS LS++T+ W+   I + +R+ +     + L ++D S +   +L K +  K + +  RK+   +  S+   A   E      N +      +SP   W   LF  L + +G   L++  FK +HD  +++ P +LK+L++++ +     W GYF  +       L +L  +  F I  +  +RI+ A+IG +YRK L + N  R   T GEIVNLMSVDA+R M+   +     S PLQ++LA+ LL+  +  ++ AG+ ++V   P+N ++    + +    +K KD RIK++ EILNGIKVLK+YAWE +F DK+  +R  E++ + + +    V    W   PFL+ L TF  YV   E NI+  + AFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    I  R   D    N   +I +R+ +F+W + D  TLN I F I  G LVA+VG+VG GKSSL+SA+L EM ++ G V+++G++AYV Q+AWIQN SL+ENILF     E +Y  +I+AC+L  DLE LP GD TEIGE+G+NLSGGQKQRVSLARAVY N DIYL DDPLSAVDAHVG+H+FENVI   G+LK+KTRILVTH +++LP+VD ++V+ S G ISE GS+++LL     F +F++ Y            G  + DE   G
Sbjct:    4 VFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRD---ITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPN--PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNW--KKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVM-SGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAG 791

HSP 2 Score: 517.694 bits (1332), Expect = 3.017e-156
Identity = 287/620 (46.29%), Postives = 415/620 (66.94%), Query Frame = 3

Query: 3048 QLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLN-NAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +L+E ++A +G VK + Y   +K+ GL++   ++ ++       + SN WL  +T+D  I N +Q                 E TK  + +Y  +G+   + V  Y  + ++G I AS+ +H  LL S+LRSPM FF+ TPSG ++NRFSK+++ +D +IP  I   +  LF V  + IVI+  TP  AI I PL ++Y+ +Q FY+ +SRQ +RL+S++ SPV++HF ETL GV++IRAF+EQ+ F + +   +D++ K  +    + RWL++R+E +G  +V  A LF++I R SL+A LVGLS+SYSLQ+T +LNWL+R  +E+ETN VA+ER++EYS+   EA W +   AP  SWP  G + F++Y LRYRE L  VL++IN+  +GG+K+G+VGRTGAGKSSL L LFR+ E+A G IIID INI+ IGLHDLR ++TI+PQDPV+FSG+LR NLDPFS + D+E++ SLE AHL+ +VS L + LD+EC EGG NLSV                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ GEI E  +P +LL    G+F S+
Sbjct:  855 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-IVNGTQ-----------------EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSM 1433

HSP 3 Score: 88.5817 bits (218), Expect = 9.525e-17
Identity = 77/276 (27.90%), Postives = 130/276 (47.10%), Query Frame = 3

Query: 1863 VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQG-------------TIAYVSQEAWIQNKSLKENI-LFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            V+++R+ +Y   E+    +I  ++    S++     +E R+    ++++    L +IN  I  G+ V IVG+ G GKSSL   +        G + + G              I  + Q+  + + SL+ N+  F+Q  +E+ +  + E   LK  +  LP   + E  E G NLS GQ+Q V LARA+ +   I +LD+  +AVD      L ++ I      +D T + + H LN +     V+VLD  G I E G+  DLL+    F    ++
Sbjct: 1168 VAVERLKEYSETEKEAPWQI--QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSL-ELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVLD-KGEIQEYGAPSDLLQQRGLFYSMAKD 1436

HSP 4 Score: 79.7221 bits (195), Expect = 4.408e-14
Identity = 74/304 (24.34%), Postives = 127/304 (41.78%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQS-LETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            LN L    + +    V+L+R+R +          +   P        +IT ++    +    P  L  I      G  + VVG+ G GKSSL  AL   ++   G +              ++  +  +PQ   I + +LREN+  F    ++  ++S ++   L   +  L  G   E GE GVNLS                       GQKQ + LARA+   + + + D+  ++VD    + +   +   +   +  T I++ H ++ +   D+I+VM  G+I E+ S + LLA  DG F
Sbjct:  495 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA-------------IKGSVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLS----------------------GGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA-RDGAF 761

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Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLL--DASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFS---KDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDN-----RSPG--W--VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALG 2720
            ++++S  +L IT++LA    ++ RR       I+  FWL A +  L  L   I+  L  DA     R+         F L L+  +  CFS  S    + +  PN  PCPE  AS LS++T+ W+   I + +R+ +     + L ++D S +   +L K +  K + +  RK+   +  S+   A   E      N +      +SP   W   LF  L + +G   L++  FK +HD  +++ P +LK+L++++ +     W GYF  +       L +L  +  F I  +  +RI+ A+IG +YRK L + N  R   T GEIVNLMSVDA+R M+   +     S PLQ++LA+ LL+  +  ++ AG+ ++V   P+N ++    + +    +K KD RIK++ EILNGIKVLK+YAWE +F DK+  +R  E++ + + +    V    W   PFL+ L TF  YV   E NI+  + AFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    I  R   D    N   +I +R+ +F+W + D  TLN I F I  G LVA+VG+VG GKSSL+SA+L EM ++ G V+++G++AYV Q+AWIQN SL+ENILF     E +Y  +I+AC+L  DLE LP GD TEIGE+G+NLSGGQKQRVSLARAVY N DIYL DDPLSAVDAHVG+H+FENVI   G+LK+KTRILVTH +++LP+VD ++V+ S G ISE GS+++LL     F +F++ Y            G  + DE   G
Sbjct:    4 VFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRD---ITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPN--PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNW--KKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVM-SGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAG 791

HSP 2 Score: 517.694 bits (1332), Expect = 3.017e-156
Identity = 287/620 (46.29%), Postives = 415/620 (66.94%), Query Frame = 3

Query: 3048 QLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLN-NAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +L+E ++A +G VK + Y   +K+ GL++   ++ ++       + SN WL  +T+D  I N +Q                 E TK  + +Y  +G+   + V  Y  + ++G I AS+ +H  LL S+LRSPM FF+ TPSG ++NRFSK+++ +D +IP  I   +  LF V  + IVI+  TP  AI I PL ++Y+ +Q FY+ +SRQ +RL+S++ SPV++HF ETL GV++IRAF+EQ+ F + +   +D++ K  +    + RWL++R+E +G  +V  A LF++I R SL+A LVGLS+SYSLQ+T +LNWL+R  +E+ETN VA+ER++EYS+   EA W +   AP  SWP  G + F++Y LRYRE L  VL++IN+  +GG+K+G+VGRTGAGKSSL L LFR+ E+A G IIID INI+ IGLHDLR ++TI+PQDPV+FSG+LR NLDPFS + D+E++ SLE AHL+ +VS L + LD+EC EGG NLSV                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ GEI E  +P +LL    G+F S+
Sbjct:  855 KLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-IVNGTQ-----------------EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSM 1433

HSP 3 Score: 88.5817 bits (218), Expect = 9.525e-17
Identity = 77/276 (27.90%), Postives = 130/276 (47.10%), Query Frame = 3

Query: 1863 VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQG-------------TIAYVSQEAWIQNKSLKENI-LFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            V+++R+ +Y   E+    +I  ++    S++     +E R+    ++++    L +IN  I  G+ V IVG+ G GKSSL   +        G + + G              I  + Q+  + + SL+ N+  F+Q  +E+ +  + E   LK  +  LP   + E  E G NLS GQ+Q V LARA+ +   I +LD+  +AVD      L ++ I      +D T + + H LN +     V+VLD  G I E G+  DLL+    F    ++
Sbjct: 1168 VAVERLKEYSETEKEAPWQI--QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSL-ELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVLD-KGEIQEYGAPSDLLQQRGLFYSMAKD 1436

HSP 4 Score: 79.7221 bits (195), Expect = 4.408e-14
Identity = 74/304 (24.34%), Postives = 127/304 (41.78%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQS-LETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            LN L    + +    V+L+R+R +          +   P        +IT ++    +    P  L  I      G  + VVG+ G GKSSL  AL   ++   G +              ++  +  +PQ   I + +LREN+  F    ++  ++S ++   L   +  L  G   E GE GVNLS                       GQKQ + LARA+   + + + D+  ++VD    + +   +   +   +  T I++ H ++ +   D+I+VM  G+I E+ S + LLA  DG F
Sbjct:  495 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA-------------IKGSVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLS----------------------GGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA-RDGAF 761

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1)

HSP 1 Score: 959.518 bits (2479), Expect = 0.000e+0
Identity = 582/1519 (38.31%), Postives = 885/1519 (58.26%), Query Frame = 3

Query:  372 IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVL-TSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSW-KKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISN-NGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAV--PIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKS-PRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFS--LTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++ Y   C+ LVL +     R R +     ++ ++WL   +  +  L   I   L    Y I +    L    +    +     CF+    +  +  N   CPE  AS L++LT+ W     Y   +K +  E  +DL  +D   K  NI+     + I      +R  + +N  A++            P N      + I + + Y   LL    +K + D   +  P LL+ L+ +I++++   WIG  +A+      +L S+  +  F     L + IR+ L   +Y KTL L+NE R   T+G IVNLMSVD +RI +   F   F S PLQI+L++  L++ +  ++ AG  +++   P N  +   M+     ++K+KD RIK+++EILNG+KVLK+Y+WEKS    +  +R+ E+R + ++S       + W   PFL+ + TF  YVL   E N++TP+  FV+L LFN+LRFP+ V     + ++    S  R+ ++   EE++         T  +    D+AI++  GSF+W  KE+   L++I F I RG+LVAIVG+VG+GKSSL+ A+LGEM++++GSV V G++AYV Q AWIQN SL+ NILF + Y+ K Y+++IE C+L  DLE LP  D TEIGE+GINLSGGQKQRVSLARAVYQN +I LLDDPLSAVD+HVG+H+FENVIS   G L  KTR+L+THGL +L   D+V+VL    +ISE G++++L+     F +F++E++   ++ K  S         + G+         D+++V E + D    SPA+   IQ   S  +    D+ +  I   +       K  + ++S + + E+ +S    ++P  ++ +  K+T            +QL+E+E   +G VK+  Y    ++ G+ + +    +Y A + L VFSN++L  +++D      ++ I L+ +GS         +T+  + IY ++G+     VC       +G + AS+++H  LL +++RSPM FFD TP GRI+NRF KDIE +D  +P +I   +  +F V +++ VII+ TPW  I  + L  +Y+++  FY+ TSRQ +RL+S + SP+++HF E++QG + IRA+     F   +Q  +D++    +    + RWL++R+E++G L+V ++   ++  R S  L+A LVGLS+SY+L IT+ LNW +R  +ELETN VA+ERI EY+  P+E     + AP  SWP NG I+ K++ +RYR GL LVL  +  H    +KIG+VGRTGAGKSSL LALFR++EA GG I ID  NI+ + L  LR RLTI+PQDPV+FSGT+R NLDPF +  DD+I+++L  AHL S+V  L EGL +   EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEA A+VDVETD L+  TIRE F+  TV+ IAHR+NT++D+D ++V++ G + E D+PK LL+  DGIF S+
Sbjct:  113 LVQYAGFCLALVLTI---ACRNRGI-ITSGVITLYWLLVVVCGVPELRYYITGRL-YKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNS--CPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERD---KAENIIPSFIENLIPEVEGYRR-KIKKNPEAAI------------PKNHPS---ILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQ-------TSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRS--------VSFGE---------DSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLH------KDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTK-----------TQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDD------AKEIALSGNGS-------SSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIEAIDQTLPHSIRAMVMTIFNVISTVFVIIWATPWAGIGFLVLGFVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSLAPK-SWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSV----------------------GQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSM 1527

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-2 (pep chromosome:WBcel235:X:563719:572701:-1 gene:WBGene00003408.1 transcript:F57C12.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-2)

HSP 1 Score: 954.51 bits (2466), Expect = 0.000e+0
Identity = 561/1438 (39.01%), Postives = 856/1438 (59.53%), Query Frame = 3

Query:  624 CFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYV-LTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELN-LTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNN-GILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFE---DEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFS--LTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA---PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            CF+    D  +  ++  CPE  AS +++LT+ W     Y   +K + +E  +DL   D   K  N++   F   +K   +    ++ ++ +A++            P N  P +V  I + + Y   LL    +K   D   +  P LLK L+ +I++++   WIG  +     F   L S+  +  +     L + +R+ L   +Y K L L+NE R   T G IVNLMSVD ++I +       F S PLQI L+I  L++ +  A  AGL +++   P+NGL+   M+K  T ++K KD RIK+++EILNG+KVLK+Y+WE+S  + +  +R+ E+  + ++S     +   W   PFL  + +F+ YV L  E N++TPE  FV+L+LF++LR P+ ++     +++   VS  R+ ++   EE++  T I+H +         D+AIE+ +G FSW  ++  TL  I+F+I +G+LVAIVGKVG+GKSSL+ A+LGEM++++GSV + G IAYV Q+AWIQN SL+ NILF + Y+ + YED+++ C+LK DL  LP GD TEIGE+GINLSGGQKQRVSLARAVYQN DI LLDDPLSAVD+HVG+H+FENVIS++ G L  KTR+LVTHGL +L   D+++VL   G+ISE G++++LL +   F +F++E++   ++ +    G+  S     G+   +LR L                 P + ++R +SH    +                      E++++   E   D   +S  + +P SQ  +        ++ +  +  +QL+E+E   +G VK+  Y    ++  + + +    +Y   +GL + SN +L   ++ +   N +                     K  + IY ++G+  + VV       T+G + AS+++H  LL +++RSPM FFD TP GRI+NR  KDIE +D  +P  I      +F V A+++VI++ TPW  IA   L+++Y+++  FYI TSRQ +RL+S + SP+++HF E++QG + IRAF     F   +Q  +D      +    + RWL++R+E++G L+V +A   ++  R S  L+A LVGLS+SY+L IT+ LNW +R  +ELETN V++ERI+EY+  P+E     NN+    + SWP  G I+ K++ +RYR GL LVL  I+ H    +K+G+VGRTGAGKSSL LALFR++EA GGSI ID INI+ + L  LR  LTI+PQDPV+FSGT++ NLDPFS++ D +++++LE AHL+ +V  L +GL+++  EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEA A+VDVETD L+  TIRE F+  TV+ IAHR+NT++D+D ++V++ G + E DSPKNLLA  DGIF S+
Sbjct:  192 CFADVPSD--MYKSESSCPEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEID---KAENLIPS-FMQNLKPRIDEYHQNIKKDPSAAL------------PKNH-PSFV--IPIFKTYKYTLLAGFFYKLCFDMLQFLAPQLLKQLIGFIEDKNQPVWIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKLSYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAMVAMVYGEAVQCSVSNTRLKEFFAAEEMSPQTSISHGE--------TDSAIEVENGLFSWSSDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIVL-KEGTISELGTYQELLNNSGAFAEFLEEFLIEESKTR----GRVASIGDGSGEVDEILRDLGQ-------------VKPGI-LKRLESHLSQESDK--------------------EDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENTQLIEKETVETGKVKFEVYIAYFQAISIPITLLFFFLYVGSSGLGILSNFYLAKLSDHAKSGNRTS-----------------SDAKMELGIYAVLGMGQSFVVLIASIILTIGVLRASRILHAGLLGNIMRSPMAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVERIKEYTVTPTEG----NNSRRLAAKSWPEKGEISIKNFSVRYRPGLDLVLHGISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSV----------------------GQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPDGIFYSM 1518

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1)

HSP 1 Score: 949.118 bits (2452), Expect = 0.000e+0
Identity = 580/1519 (38.18%), Postives = 881/1519 (58.00%), Query Frame = 3

Query:  372 IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVL-TSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSW-KKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISN-NGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAV--PIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKS-PRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFS--LTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++ Y   C+ LVL +     R R +     ++ ++WL   +  +  L   I   L    Y I +    L    +    +     CF+    +  +  N   CPE  AS L++LT+ W     Y   +K +  E  +DL  +D   K  NI+     + I      +R  + +N  A++            P N      + I + + Y   LL    +K + D   +  P LL+ L+ +I++++   WIG  +A+      +L S+  +  F     L + IR+ L   +Y KTL L+NE R   T+G IVNLMSVD +RI +   F   F S PLQI+L++  L++ +  ++ AG  +++   P N  +   M+     ++K+KD RIK+++EILNG+KVLK+Y+WEKS    +  +R+ E+R + ++S       + W   PFL+ + TF  YVL   E N++TP+  FV+L LFN+LRFP+ V     + ++    S  R+ ++   EE++         T  +    D+AI++  GSF+W  KE+   L++I F I RG+LVAIVG+VG+GKSSL+ A+LGEM++++GSV V G++AYV Q AWIQN SL+ NILF + Y+ K Y+++IE C+L  DLE LP  D TEIGE+GINLSGGQKQRVSLARAVYQN +I LLDDPLSAVD+HVG+H+FENVIS   G L  KTR+L+THGL +L   D+V+VL  + +ISE G++++L+     F +F++E++   ++ K  S         + G+         D+++V E + D    SPA+   IQ   S  +    D+ +  I   +       K  + ++S + + E+ +S    ++P  ++ +  K+T            +QL+E+E   +G VK+  Y    ++ G+ + +    +Y A + L VFSN++L  +++D      ++ I L+ +GS         +T+  + IY ++G+     VC       +G + AS+++H  LL +++RSPM FFD TP GRI+NRF KD++ +D  +P NI D L     + A ++   Y TP+    I+ +AI  + I  FY+ TSRQ +RL+S + SP+++HF E++QG + IRA+     F   +Q  +D++    +    + RWL++R+E++G L+V ++   ++  R S  L+A LVGLS+SY+L IT+ LNW +R  +ELETN VA+ERI EY+  P+E     + AP  SWP NG I+ K++ +RYR GL LVL  +  H    +KIG+VGRTGAGKSSL LALFR++EA GG I ID  NI+ + L  LR RLTI+PQDPV+FSGT+R NLDPF +  DD+I+++L  AHL S+V  L EGL +   EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEA A+VDVETD L+  TIRE F+  TV+ IAHR+NT++D+D ++V++ G + E D+PK LL+  DGIF S+
Sbjct:  113 LVQYAGFCLALVLTI---ACRNRGI-ITSGVITLYWLLVVVCGVPELRYYITGRL-YKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNS--CPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERD---KAENIIPSFIENLIPEVEGYRR-KIKKNPEAAI------------PKNHPS---ILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQ-------TSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVL-KDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRS--------VSFGE---------DSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLH------KDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTK-----------TQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDD------AKEIALSGNGS-------SSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDMDVVDERLPDNIGDFLLTFSELVACVVFTSYATPFAIFPIVLIAIGCFAILRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSLAPK-SWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSV----------------------GQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSM 1527

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1)

HSP 1 Score: 944.495 bits (2440), Expect = 0.000e+0
Identity = 579/1519 (38.12%), Postives = 878/1519 (57.80%), Query Frame = 3

Query:  372 IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVL-TSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSW-KKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISN-NGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAV--PIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKS-PRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFS--LTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++ Y   C+ LVL +     R R +     ++ ++WL   +  +  L   I   L    Y I +    L    +    +     CF+    +  +  N   CPE  AS L++LT+ W     Y   +K +  E  +DL  +D   K  NI+     + I      +R  + +N  A++            P N      + I + + Y   LL    +K + D   +  P LL+ L+ +I++++   WIG  +A+      +L S+  +  F     L + IR+ L   +Y KTL L+NE R   T+G IVNLMSVD +RI +   F   F S PLQI+L++  L++ +  ++ AG  +++   P N  +   M+     ++K+KD RIK+++EILNG+KVLK+Y+WEKS    +  +R+ E+R + ++S       + W   PFL+ + TF  YVL   E N++TP+  FV+L LFN+LRFP+ V     + ++    S  R+ ++   EE++         T  +    D+AI++  GSF+W  KE+   L++I F I RG+LVAIVG+VG+GKSSL+ A+LGEM++++GSV V G++AYV Q AWIQN SL+ NILF + Y+ K Y+++IE C+L  DLE LP  D TEIGE+GINLSGGQKQRVSLARAVYQN +I LLDDPLSAVD+HVG+H+FENVIS   G L  KTR+L+THGL +L   D+V+VL  + +ISE G++++L+     F +F++E++   ++ K  S         + G+         D+++V E + D    SPA+   IQ   S  +    D+ +  I   +       K  + ++S + + E+ +S    ++P  ++ +  K+T            +QL+E+E   +G VK+  Y    ++ G+ + +    +Y A + L VFSN++L  +++D      ++ I L+ +GS         +T+  + IY ++G+     VC       +G + AS+++H  LL +++RSPM FFD TP GRI+NRF KDI+ +D+ +P  I   +  +        V IY TP  +  I  + I YY +  FY+ TSRQ +RL+S + SP+++HF E++QG + IRA+     F   +Q  +D++    +    + RWL++R+E++G L+V ++   ++  R S  L+A LVGLS+SY+L IT+ LNW +R  +ELETN VA+ERI EY+  P+E     + AP  SWP NG I+ K++ +RYR GL LVL  +  H    +KIG+VGRTGAGKSSL LALFR++EA GG I ID  NI+ + L  LR RLTI+PQDPV+FSGT+R NLDPF +  DD+I+++L  AHL S+V  L EGL +   EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEA A+VDVETD L+  TIRE F+  TV+ IAHR+NT++D+D ++V++ G + E D+PK LL+  DGIF S+
Sbjct:  113 LVQYAGFCLALVLTI---ACRNRGI-ITSGVITLYWLLVVVCGVPELRYYITGRL-YKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNS--CPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERD---KAENIIPSFIENLIPEVEGYRR-KIKKNPEAAI------------PKNHPS---ILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQ-------TSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVL-KDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRS--------VSFGE---------DSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLH------KDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTK-----------TQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDD------AKEIALSGNGS-------SSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIDVIDYRLPSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITIVLIGYYFLLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSLAPK-SWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSV----------------------GQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSM 1527

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1)

HSP 1 Score: 943.34 bits (2437), Expect = 0.000e+0
Identity = 578/1519 (38.05%), Postives = 882/1519 (58.06%), Query Frame = 3

Query:  372 IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVL-TSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSW-KKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISN-NGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAV--PIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKS-PRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFS--LTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++ Y   C+ LVL +     R R +     ++ ++WL   +  +  L   I   L    Y I +    L    +    +     CF+    +  +  N   CPE  AS L++LT+ W     Y   +K +  E  +DL  +D   K  NI+     + I      +R  + +N  A++            P N      + I + + Y   LL    +K + D   +  P LL+ L+ +I++++   WIG  +A+      +L S+  +  F     L + IR+ L   +Y KTL L+NE R   T+G IVNLMSVD +RI +   F   F S PLQI+L++  L++ +  ++ AG  +++   P N  +   M+     ++K+KD RIK+++EILNG+KVLK+Y+WEKS    +  +R+ E+R + ++S       + W   PFL+ + TF  YVL   E N++TP+  FV+L LFN+LRFP+ V     + ++    S  R+ ++   EE++         T  +    D+AI++  GSF+W  KE+   L++I F I RG+LVAIVG+VG+GKSSL+ A+LGEM++++GSV V G++AYV Q AWIQN SL+ NILF + Y+ K Y+++IE C+L  DLE LP  D TEIGE+GINLSGGQKQRVSLARAVYQN +I LLDDPLSAVD+HVG+H+FENVIS   G L  KTR+L+THGL +L   D+V+VL  + +ISE G++++L+     F +F++E++   ++ K  S         + G+         D+++V E + D    SPA+   IQ   S  +    D+ +  I   +       K  + ++S + + E+ +S    ++P  ++ +  K+T            +QL+E+E   +G VK+  Y    ++ G+ + +    +Y A + L VFSN++L  +++D      ++ I L+ +GS         +T+  + IY ++G+     VC       +G + AS+++H  LL +++RSPM FFD TP GRI+NRF KD++ +D  IP  +S  +         I +I++ TP     ++PL I+Y+++  FY+ TSRQ +RL+S + SP+++HF E++QG + IRA+     F   +Q  +D++    +    + RWL++R+E++G L+V ++   ++  R S  L+A LVGLS+SY+L IT+ LNW +R  +ELETN VA+ERI EY+  P+E     + AP  SWP NG I+ K++ +RYR GL LVL  +  H    +KIG+VGRTGAGKSSL LALFR++EA GG I ID  NI+ + L  LR RLTI+PQDPV+FSGT+R NLDPF +  DD+I+++L  AHL S+V  L EGL +   EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEA A+VDVETD L+  TIRE F+  TV+ IAHR+NT++D+D ++V++ G + E D+PK LL+  DGIF S+
Sbjct:  113 LVQYAGFCLALVLTI---ACRNRGI-ITSGVITLYWLLVVVCGVPELRYYITGRL-YKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNS--CPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERD---KAENIIPSFIENLIPEVEGYRR-KIKKNPEAAI------------PKNHPS---ILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQ-------TSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVL-KDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRS--------VSFGE---------DSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLH------KDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTK-----------TQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDD------AKEIALSGNGS-------SSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSLAPK-SWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSV----------------------GQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSM 1527

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090025)

HSP 1 Score: 992.645 bits (2565), Expect = 0.000e+0
Identity = 566/1423 (39.78%), Postives = 851/1423 (59.80%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISH-NRKRYD-LLQNSTASVAHLMEDEDKLTNPDNRSPGWV-LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNR-SDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTD-------RLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL---NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            PE+ AS LS++TY W D    K +R  + ++  +DLR QD  ++   I    +   ++ ++ N+ R +   Q S  +V      E+     + R  G   +   + + +G   L     K   D   +A P +L +++ +++ + ++  W G   A+         +      F    I+ +RIR ALI  IYRK LR++N  + + T GEIVNLM+VDA+R M    +     S PLQI LA+  L+Q++  ++ AGL +++   P+NG++ + ++ +   ++K+KD R+K++ E+L+GIKVLK+YAWE SF  ++ ++RD E+  +   +        LW   PFL+ L TF  YVL  E N++   K FVSL+LFN+LRFP+ +LP  +T+ +   VS+ RI ++L  EEL+   + H     DS+  +  +IE  +G FSW   D++TL NIN E+ +G LVA+VG VG+GKSS++ A LGEM ++ G V+  G +AYV Q+AWIQN ++++NILF Q Y+ K Y  +I+AC+L++D++ L  GD TEIGE+GINLSGGQKQR+SLARAVY + D+YLLDDPLSAVDAHVG+H+FE VI   GIL  K+R+LVTHG+ +LP+VD + V+   G ISE G+F  L+K+   F  F+   I+H                    +   + RQ+S   DV E +        A+ + R +S                             +S S    D       +M  G   R+ +K  D +         +   +   +L+E E++ +G V++A Y   IKS G++L +AT+ +   F   Q+ SN+WL  +  D ++ N +                +R+    Y+ +Y   G        F   +  +GS++A+KV+H  LL +VLR+PM  FDTTP GRI++RFSKD+E++D  +P  I+D + C F V A+I+VI   TP F   I+P+A LYY  Q FY+ TSRQ  RL+S++ SP+++HF+ET+ G + IRA+     F   +   +DK+   K+    + RWL++R+E++G L++  A LF+++G       LVGLS+SY+LQ+T+ LNWL+R  +++ETN V++ERI+EY +   EA W+L    N P + WP  G + F+++ +RYREGL LVL+ ++ +  GG+K+G+VGRTGAGKSSL LALFR++EAAGG I ID ++I+++GLH LR RLTI+PQDPV+FSG+LR NLDPF    DDEI+++LE +HL+S+V  L+ GL++E  EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTILD+D ++V++ G+I+E  SP  LL      F S+
Sbjct:  225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTF----ENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLH-----DSSKPHPMSIE--NGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKM-GEISESGTFDQLVKNKGAFADFI---IQHLQEGN-----------EEEEELNQIKRQISSTADVPELLGT---VEKAIKLARTES---------------------------LSDSISVTSADS------LMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTG---------------LRDM---YLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKN-WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSV----------------------GQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1541

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090020)

HSP 1 Score: 987.638 bits (2552), Expect = 0.000e+0
Identity = 564/1423 (39.63%), Postives = 848/1423 (59.59%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISH-NRKRYD-LLQNSTASVAHLMEDEDKLTNPDNRSPGWV-LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNR-SDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTD-------RLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL---NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            PE+ AS LS++TY W D    K +R  + ++  +DLR QD  ++   I    +   ++ ++ N+ R +   Q S  +V      E+     + R  G   +   + + +G   L     K   D   +A P +L +++ +++ + ++  W G   A+         +      F    I+ +RIR ALI  IYRK LR++N  + + T GEIVNLM+VDA+R M    +     S PLQI LA+  L+Q++  ++ AGL +++   P+NG++ + ++ +   ++K+KD R+K++ E+L+GIKVLK+YAWE SF  ++ ++RD E+  +   +        LW   PFL+ L TF  YVLTSE N ++ EK  VS+ LF+L++ P+ +LP    D     VS+ RI ++L  EEL+   + H     DS+  +  +IE  +G FSW   D++TL NIN E+ +G LVA+VG VG+GKSS++ A LGEM ++ G V+  G +AYV Q+AWIQN ++++NILF Q Y+ K Y  +I+AC+L++D++ L  GD TEIGE+GINLSGGQKQR+SLARAVY + D+YLLDDPLSAVDAHVG+H+FE VI   GIL  K+R+LVTHG+ +LP+VD + V+   G ISE G+F  L+K+   F  F+   I+H                    +   + RQ+S   DV E +        A+ + R +S                             +S S    D       +M  G   R+ +K  D +         +   +   +L+E E++ +G V++A Y   IKS G++L +AT+ +   F   Q+ SN+WL  +  D ++ N +                +R+    Y+ +Y   G        F   +  +GS++A+KV+H  LL +VLR+PM  FDTTP GRI++RFSKD+E++D  +P  I+D + C F V A+I+VI   TP F   I+P+A LYY  Q FY+ TSRQ  RL+S++ SP+++HF+ET+ G + IRA+     F   +   +DK+   K+    + RWL++R+E++G L++  A LF+++G       LVGLS+SY+LQ+T+ LNWL+R  +++ETN V++ERI+EY +   EA W+L    N P + WP  G + F+++ +RYREGL LVL+ ++ +  GG+K+G+VGRTGAGKSSL LALFR++EAAGG I ID ++I+++GLH LR RLTI+PQDPV+FSG+LR NLDPF    DDEI+++LE +HL+S+V  L+ GL++E  EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTILD+D ++V++ G+I+E  SP  LL      F S+
Sbjct:  225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTF----ENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLH-----DSSKPHPMSIE--NGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKM-GEISESGTFDQLVKNKGAFADFI---IQHLQEGN-----------EEEEELNQIKRQISSTADVPELLGT---VEKAIKLARTES---------------------------LSDSISVTSADS------LMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTG---------------LRDM---YLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKN-WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSV----------------------GQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1541

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090022)

HSP 1 Score: 984.171 bits (2543), Expect = 0.000e+0
Identity = 562/1423 (39.49%), Postives = 848/1423 (59.59%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISH-NRKRYD-LLQNSTASVAHLMEDEDKLTNPDNRSPGWV-LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNR-SDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTD-------RLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL---NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            PE+ AS LS++TY W D    K +R  + ++  +DLR QD  ++   I    +   ++ ++ N+ R +   Q S  +V      E+     + R  G   +   + + +G   L     K   D   +A P +L +++ +++ + ++  W G   A+         +      F    I+ +RIR ALI  IYRK LR++N  + + T GEIVNLM+VDA+R M    +     S PLQI LA+  L+Q++  ++ AGL +++   P+NG++ + ++ +   ++K+KD R+K++ E+L+GIKVLK+YAWE SF  ++ ++RD E+  +   +        LW   PFL+ L TF  YVL  E N++   K FVSL+LFN+LRFP+ +LP  +T+ +   VS+ RI ++L  EEL+   + H     DS+  +  +IE  +G FSW   D++TL NIN E+ +G LVA+VG VG+GKSS++ A LGEM ++ G V+  G +AYV Q+AWIQN ++++NILF Q Y+ K Y  +I+AC+L++D++ L  GD TEIGE+GINLSGGQKQR+SLARAVY + D+YLLDDPLSAVDAHVG+H+FE VI   GIL  K+R+LVTHG+ +LP+VD + V+   G ISE G+F  L+K+   F  F+   I+H                    +   + RQ+S   DV E +        A+ + R +S                             +S S    D       +M  G   R+ +K  D +         +   +   +L+E E++ +G V++A Y   IKS G++L +AT+ +   F   Q+ SN+WL  +  D ++ N +                +R+    Y+ +Y   G        F   + ++G +  S+++H+ LL   LR PME FDTTP GRI+NRFSKDI+ +D+++P NI   +   ++V A+I+VI   TP F   I+P+A LYY  Q FY+ TSRQ  RL+S++ SP+++HF+ET+ G + IRA+     F   +   +DK+   K+    + RWL++R+E++G L++  A LF+++G       LVGLS+SY+LQ+T+ LNWL+R  +++ETN V++ERI+EY +   EA W+L    N P + WP  G + F+++ +RYREGL LVL+ ++ +  GG+K+G+VGRTGAGKSSL LALFR++EAAGG I ID ++I+++GLH LR RLTI+PQDPV+FSG+LR NLDPF    DDEI+++LE +HL+S+V  L+ GL++E  EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTILD+D ++V++ G+I+E  SP  LL      F S+
Sbjct:  225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTF----ENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLH-----DSSKPHPMSIE--NGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKM-GEISESGTFDQLVKNKGAFADFI---IQHLQEGN-----------EEEEELNQIKRQISSTADVPELLGT---VEKAIKLARTES---------------------------LSDSISVTSADS------LMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTG---------------LRDM---YLGVYGAFGFGQVATNFFSSLAISLGCLKCSQLLHQTLLYYNLRWPMELFDTTPLGRIVNRFSKDIDTIDNVLPFNIRVVIGQAYMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKN-WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSV----------------------GQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1541

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090023)

HSP 1 Score: 983.786 bits (2542), Expect = 0.000e+0
Identity = 564/1423 (39.63%), Postives = 846/1423 (59.45%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISH-NRKRYD-LLQNSTASVAHLMEDEDKLTNPDNRSPGWV-LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNR-SDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTD-------RLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL---NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            PE+ AS LS++TY W D    K +R  + ++  +DLR QD  ++   I    +   ++ ++ N+ R +   Q S  +V      E+     + R  G   +   + + +G   L     K   D   +A P +L +++ +++ + ++  W G   A+         +      F    I+ +RIR ALI  IYRK LR++N  + + T GEIVNLM+VDA+R M    +     S PLQI LA+  L+Q++  ++ AGL +++   P+NG++ + ++ +   ++K+KD R+K++ E+L+GIKVLK+YAWE SF  ++ ++RD E+  +   +        LW   PFL+ L TF  YVL  E N++   K FVSL+LFN+LRFP+ +LP  +T+ +   VS+ RI ++L  EEL+   + H     DS+  +  +IE  +G FSW   D++TL NIN E+ +G LVA+VG VG+GKSS++ A LGEM ++ G V+  G +AYV Q+AWIQN ++++NILF Q Y+ K Y  +I+AC+L++D++ L  GD TEIGE+GINLSGGQKQR+SLARAVY + D+YLLDDPLSAVDAHVG+H+FE VI   GIL  K+R+LVTHG+ +LP+VD + V+   G ISE G+F  L+K+   F  F+   I+H                    +   + RQ+S   DV E +        A+ + R +S                             +S S    D       +M  G   R+ +K  D +         +   +   +L+E E++ +G V++A Y   IKS G++L +AT+ +   F   Q+ SN+WL  +  D ++ N +                +R+    Y+ +Y   G        F   +  +G I  SKV+H+ LL  V R PME FDTTP GR++NRFSKD++ +D+++PM     +S  F V A+I+VI   TP F   I+P+A LYY  Q FY+ TSRQ  RL+S++ SP+++HF+ET+ G + IRA+     F   +   +DK+   K+    + RWL++R+E++G L++  A LF+++G       LVGLS+SY+LQ+T+ LNWL+R  +++ETN V++ERI+EY +   EA W+L    N P + WP  G + F+++ +RYREGL LVL+ ++ +  GG+K+G+VGRTGAGKSSL LALFR++EAAGG I ID ++I+++GLH LR RLTI+PQDPV+FSG+LR NLDPF    DDEI+++LE +HL+S+V  L+ GL++E  EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTILD+D ++V++ G+I+E  SP  LL      F S+
Sbjct:  225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTF----ENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLH-----DSSKPHPMSIE--NGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKM-GEISESGTFDQLVKNKGAFADFI---IQHLQEGN-----------EEEEELNQIKRQISSTADVPELLGT---VEKAIKLARTES---------------------------LSDSISVTSADS------LMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTG---------------LRDM---YLGVYGAFGFGQVTSYFFCSLTLALGCIFCSKVLHETLLSYVFRWPMELFDTTPLGRVVNRFSKDVDTIDNVLPMLWRMVISQAFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKN-WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSV----------------------GQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1541

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090026)

HSP 1 Score: 979.163 bits (2530), Expect = 0.000e+0
Identity = 559/1423 (39.28%), Postives = 845/1423 (59.38%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISH-NRKRYD-LLQNSTASVAHLMEDEDKLTNPDNRSPGWV-LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNR-SDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTD-------RLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL---NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            PE+ AS LS++TY W D    K +R  + ++  +DLR QD  ++   I    +   ++ ++ N+ R +   Q S  +V      E+     + R  G   +   + + +G   L     K   D   +A P +L +++ +++ + ++  W G   A+         +      F    I+ +RIR ALI  IYRK LR++N  + + T GEIVNLM+VDA+R M    +     S PLQI LA+  L+Q++  ++ AGL +++   P+NG++ + ++ +   ++K+KD R+K++ E+L+GIKVLK+YAWE SF  ++ ++RD E+  +   +        LW   PFL+ L TF  YVL  E N++   K FVSL+LFN+LRFP+ +LP  +T+ +   VS+ RI ++L  EEL+   + H     DS+  +  +IE  +G FSW   D++TL NIN E+ +G LVA+VG VG+GKSS++ A LGEM ++ G V+  G +AYV Q+AWIQN ++++NILF Q Y+ K Y  +I+AC+L++D++ L  GD TEIGE+GINLSGGQKQR+SLARAVY + D+YLLDDPLSAVDAHVG+H+FE VI   GIL  K+R+LVTHG+ +LP+VD + V+   G ISE G+F  L+K+   F  F+   I+H                    +   + RQ+S   DV E +        A+ + R +S                             +S S    D       +M  G   R+ +K  D +         +   +   +L+E E++ +G V++A Y   IKS G++L +AT+ +   F   Q+ SN+WL  +  D ++ N +                +R+    Y+ +Y   G    +         ++G + +++ +H  LL   LR PME FD TP GRI+NRFSKD++ +D+ +P+N+   +  LF V A+I+VI   TP F   I+P+A LYY  Q FY+ TSRQ  RL+S++ SP+++HF+ET+ G + IRA+     F   +   +DK+   K+    + RWL++R+E++G L++  A LF+++G       LVGLS+SY+LQ+T+ LNWL+R  +++ETN V++ERI+EY +   EA W+L    N P + WP  G + F+++ +RYREGL LVL+ ++ +  GG+K+G+VGRTGAGKSSL LALFR++EAAGG I ID ++I+++GLH LR RLTI+PQDPV+FSG+LR NLDPF    DDEI+++LE +HL+S+V  L+ GL++E  EGG NLSV                      GQ+QL+CLARALLRK+KVL+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTILD+D ++V++ G+I+E  SP  LL      F S+
Sbjct:  225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTF----ENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLH-----DSSKPHPMSIE--NGEFSWG--DEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKM-GEISESGTFDQLVKNKGAFADFI---IQHLQEGN-----------EEEEELNQIKRQISSTADVPELLGT---VEKAIKLARTES---------------------------LSDSISVTSADS------LMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTG---------------LRDM---YLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKN-WPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSV----------------------GQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSM 1541

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:ZFIN;Acc:ZDB-GENE-050517-16])

HSP 1 Score: 1006.9 bits (2602), Expect = 0.000e+0
Identity = 599/1550 (38.65%), Postives = 906/1550 (58.45%), Query Frame = 3

Query:  348 NSLIDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSS----FSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNT-NILEKIFYDKIKISHNRKRYDLLQNST-------ASVAHLMEDEDK----LTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFG--VLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEY-----IEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKP-ISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWD-LNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSL 4919
             S I  +Y ++ +I+ +T++LA    +  R        +LFIFW  + +  ++     I+         +R          F   L+  +  CF+     FS   ++ PN   CPE  A  LS++T+ W      K ++  + ++  + L + D S      +L +   +K K +H+    ++ +  T       A   H+ E  ++    L+    +S       +L R +G   L+  AFK + D   +  P LL++L+ + +      W GY  A+AFL FG  +L +L  +  F    +  +R+R  +IG IYRK L + NE +   T GE+VNLMSVDA+R M+   F     S PLQI LA+  L+Q +  ++ AG+ ++V   P N  +    + +   ++K+KD RIK++ EILNGIKVLK+YAWE SF DKI  +R  E+ ++LR +A    +  + W   PFL+ L +F  +V   E N++  EKAFVSL+LFN+LRFP+ +LP  ++  + A VSLKR+  +L  +EL+   ++ +  T + A      + + +G FSW K D++ L+NIN  + +G L+A+VG VG GK+SLISA+LGEM +++G +S++G++AYV Q+AWIQN +L++NILF + Y E+ Y  ++EAC+L  DLE LPGGD TEIGE+GINLSGGQ+QRVSLARA+Y   D+YLLDDPLSAVDAHV +H+F++VI   G LK KTRILVTHG+++LP+V+ +LVL  +G +SE GS++DLL+    F +F++ Y     IE +    +    +    E AL    +++    DNE VV E     +   ++         +SN                                  D ++P+ M   S+ R+ S+     T     +P + +L++ E   +G VK   Y   +K+ G  L +    +Y   +   + +N WL  +T D+ + N +Q +L               QT+  + +Y  +G+   ++V F   +  +G I A++ +H+ LL +  ++P  FFDTTP+GRIINRFSKDI  +D ++P  +   L   F   +++IVII  TP FA  I PLA++Y+ +Q FY+ TSRQ +RL+S++ SP+++HF+E++ G ++IRA+     F  ++   +D++ K  +    S RWL +RIE +G  +V  A LF++ G+  L+  LVGLS+SY+LQ+T  LNW++R  ++LE+N VA+ER++EYS+  +EA W+ L   P   WP  GN+ F DY +RYREGL LVLKNI+L   GG+KIG+VGRTGAGKSS+ L LFRL+EAA G I+ID + IS IGLHDLR +LTI+PQ+PV+FSGTLR NLDPF  + D+E++++LE +HLQ +V+  +  L+ EC EGG NLSV                      GQ+QL+CLARALLRK+++L+LDEATA+VD+ETD L+  TIR  FQ  TV  IAHR+NTI+D   ++V++ G+I E D+P NL+      F    D  L
Sbjct:   95 GSKISPIYFVTPLIVGMTMLLATFLIQFERLKGVQSSGVLFIFWTLSVVFAIVPFRSKIMHANTEVKDKLR---FTTFYIYFSFTLLELILSCFNEKPPLFS-SAVMDPNV--CPETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSK-AHSSDDQNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFGPYFLIGSAFKLLQDLITFINPQLLRMLIAFTKQSDVPSWWGY--ALAFLMFGTSLLQTLILHQHFQYCFVTGMRLRTGIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIFLALFFLWQNLGPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEILNGIKVLKLYAWEPSFRDKILQIRQKEL-HVLRKTAYLSALSTMAWTSAPFLVALTSFAVFVNVDEKNVLDAEKAFVSLSLFNILRFPLNMLPQVISSIVQASVSLKRLQDFLNHDELDPESVDRKSNTTEYA------VSVVNGKFSWAKRDQVILDNINVLVPQGSLLAVVGHVGCGKTSLISALLGEMEKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILVTHGISFLPQVNNILVL-VDGRVSEMGSYQDLLRQNGAFAEFLRNYSLEDIIEDDELTVSFDEEEEEFPEDALSNHTDMV----DNEPVVNEARRQFMRQMSI---------MSN----------------------------------DVENPKKM---SRRRRCSERKHPETPTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIGPLLALFICFLYGCQSAAAIGANFWLSEWTNDA-LHNRTQEML---------------QTR--VGVYAALGISQGILVMFSSFTLALGKIQAARKLHQVLLENKFQTPQSFFDTTPTGRIINRFSKDIYVVDEVLPSTLLMFLGTFFASLSTMIVIISSTPVFAFVIAPLALIYFFVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYGRNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAALFAVTGKDKLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETQTEAPWEVLEKKPPPDWPPLGNVEFVDYSVRYREGLDLVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLELECSEGGENLSV----------------------GQRQLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMDYTRVLVLDKGQIAEFDTPTNLMNQKGLFFGMAKDAGL 1537

HSP 2 Score: 73.559 bits (179), Expect = 2.674e-12
Identity = 67/250 (26.80%), Postives = 111/250 (44.40%), Query Frame = 3

Query: 4185 LVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNN 4925
            ++L NIN+    G  + VVG  G GK+SL  AL   +E   G I              +R  +  +PQ   I + TLR+N+     + + +    LE   L   +  L  G   E GE G+NLS                       GQ+Q + LARAL  ++ V +LD+  ++VD    + +  H I      +  T I++ H I+ +   + I+V+ +G + E+ S ++LL  +    + L + SL +
Sbjct:  654 VILDNINVLVPQGSLLAVVGHVGCGKTSLISALLGEMEKLDGQI-------------SIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLS----------------------GGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILVTHGISFLPQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLRNYSLED 868

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1523])

HSP 1 Score: 981.474 bits (2536), Expect = 0.000e+0
Identity = 572/1441 (39.69%), Postives = 863/1441 (59.89%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPD------------------------NRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSP----AVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            PE  A+ LS++T++W ++ ++K F++ +  E  +DL + D +       E +   ++K + N  +    +      A       K  + D                        +  P   L  ++ + +   LL +  FK + D   +A P LLK+++ + QN+    W GY  A+  +    + S+     F    IL +++R A++  +Y+K L ++N+ R + T+GEIVNLMS DA+R  +   F     SCPLQI L+I  L+ E+  ++ +GL ++V   P+NG L    ++F    +K+KD R+KI+ ++LNGIK+LK YAWE SF  ++  +R+ E++ + + +    V   ++   P L+ LATF  +V  S  NI+  EKAF S++LFN+LRFP+ +LP  ++  +   VS KR+ ++L G++L+ T + H         +  AA+ + +G+++W+++ +  L  ++ +I  G+LVA+VG VG+GK+SL+SA+LGE+H I G++++ G++AYV Q+AWIQN +LK+NILF    +E+ Y+ +I+AC+L+ DL+ LPG D+TEIGE+GINLSGGQKQRVSLARAVY + D+YLLDDPLSAVD+HVG+HLFE VI  NG+L+DKTRILVTHG+++LP VDE++VL  +G +SE GS++ L      F +F++ Y +  +   N        D+ A      +  ++    + +E   D    SP    +  ++R +S R S    + + S+                 NS +   +DP+                          DK   +L+E+E   +G VK++ Y   + + G W    +   Y       +  N+WL ++T+DS I+  +Q           +   IR+     + ++  +GL    +V F       GSI+AS+ +H  LL ++L+ PM FFDTTPSGRI+NRF+KDI  +D +IPM+    + CL  V  ++ VI   TP F   ++P+A++YY +Q FY+ TSRQ RRLDS++ SP+++HF ET+ G+++IRA+  Q  F   N+  ID++ K  +    S RWL++R+E LG L+VF A LF++I R SL + LVGLSISY+L +T+ LNWL+R  +ELETN VA+ER+REY++I +EA W  +  P D WP+ GNI F+DY +RYR  L LVL  +       +KIG+VGRTGAGKSSL   LFR+VEAA G I+ID I+I+T+GLHDLR RLTI+PQDPV+FSGTLR NLDPF +  D EI+  LE AHL+ +V GL  GL++E  EGG NLS+                      GQ+QLLCLARALLRKS++LILDEATA+VD+ETD L+  TIR  F   TV+ IAHR+NTILD+  ++V+++G+IVE DSP  LL+   G F S+ + +
Sbjct:  208 PEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDLDTTTVTHNS-------SITAAVSMTNGTYAWERDTEPVLKQVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALEPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILVTHGISFLPYVDEIVVL-VHGVVSEIGSYESLRASKGAFSEFLETYGKDESNKDN--------DKKAAAAQTPVYEEIETLPEGLETQAD---GSPEDIVSSTLKRENSLRHSQRHSKRNGSVKV-------------RKNSSLRAQKDPE--------------------------DKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWTDDS-IEYFNQT----------YPNHIRDTR---IGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEDTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSL----------------------GQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLS-KPGHFSSMAEDA 1553

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1523])

HSP 1 Score: 981.089 bits (2535), Expect = 0.000e+0
Identity = 574/1441 (39.83%), Postives = 864/1441 (59.96%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPD------------------------NRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSP----AVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            PE  A+ LS++T++W ++ ++K F++ +  E  +DL + D +       E +   ++K + N  +    +      A       K  + D                        +  P   L  ++ + +   LL +  FK + D   +A P LLK+++ + QN+    W GY  A+  +    + S+     F    IL +++R A++  +Y+K L ++N+ R + T+GEIVNLMS DA+R  +   F     SCPLQI L+I  L+ E+  ++ +GL ++V   P+NG L    ++F    +K+KD R+KI+ ++LNGIK+LK YAWE SF  ++  +R+ E++ + + +    V   ++   P L+ LATF  +V  S  NI+  EKAF S++LFN+LRFP+ +LP  ++  +   VS KR+ ++L G++L+ T + H     DS+    AA+ + +G+++W+++ +  L  ++ +I  G+LVA+VG VG+GK+SL+SA+LGE+H I G++++ G++AYV Q+AWIQN +LK+NILF    +E+ Y+ +I+AC+L  DL+ LPG D+TEIGE+GINLSGGQKQRVSLARAVY + D+YLLDDPLSAVD+HVG+HLFE VI  NG+L+DKTRILVTHG+++LP VDE++VL  +G +SE GS++ L      F +F++ Y +  +   N        D+ A      +  ++    + +E   D    SP    +  ++R +S R S    + + S+                 NS +   +DP+                          DK   +L+E+E   +G VK++ Y   + + G W    +   Y       +  N+WL ++T+DS I+  +Q           +   IR+     + ++  +GL    +V F       GSI+AS+ +H  LL ++L+ PM FFDTTPSGRI+NRF+KDI  +D +IPM+    + CL  V  ++ VI   TP F   ++P+A++YY +Q FY+ TSRQ RRLDS++ SP+++HF ET+ G+++IRA+  Q  F   N+  ID++ K  +    S RWL++R+E LG L+VF A LF++I R SL + LVGLSISY+L +T+ LNWL+R  +ELETN VA+ER+REY++I +EA W  +  P D WP+ GNI F+DY +RYR  L LVL  +       +KIG+VGRTGAGKSSL   LFR+VEAA G I+ID I+I+T+GLHDLR RLTI+PQDPV+FSGTLR NLDPF +  D EI+  LE AHL+ +V GL  GL++E  EGG NLS+                      GQ+QLLCLARALLRKS++LILDEATA+VD+ETD L+  TIR  F   TV+ IAHR+NTILD+  ++V+++G+IVE DSP  LL+   G F S+ + +
Sbjct:  194 PEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDLDTTTVTH-----DSSIT--AAVSMTNGTYAWERDTEPVLKQVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILVTHGISFLPYVDEIVVL-VHGVVSEIGSYESLRASKGAFSEFLETYGKDESNKDN--------DKKAAAAQTPVYEEIETLPEGLETQAD---GSPEDIVSSTLKRENSLRHSQRHSKRNGSVKV-------------RKNSSLRAQKDPE--------------------------DKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWTDDS-IEYFNQT----------YPNHIRDTR---IGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSL----------------------GQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLS-KPGHFSSMAEDA 1539

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc12 (ATP-binding cassette, sub-family C (CFTR/MRP), member 12 [Source:ZFIN;Acc:ZDB-GENE-050517-25])

HSP 1 Score: 683.33 bits (1762), Expect = 0.000e+0
Identity = 469/1447 (32.41%), Postives = 759/1447 (52.45%), Query Frame = 3

Query:  690 ASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMP-FLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSIL-------SIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDF-TDDSAFNYDAAIEIRDGSFSW---------------------KKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPG---SQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSM-CIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLN---ISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAF-KEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIG-RFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREY-SKIPSEAEWDLNNA--PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            A   S  ++SW+   +++ FR  + DE S  L   D +  N    ++++ +++       R  L + S ++V                         + R      +++     +  F+++  P  L+  +L Y++ +S+   + + + +    F     L E    F  S+L       ++R++ A   + ++K + L +      T GE +N+++ D  R+ + +IF  F L  P+ +++ II     + Y    G+ + + F P+   +  L+  F    +   D R++ + E+L  IK++KMYAWE+SF   IT++R  E   + +      +   L  I+P L  + TF+ +  TS    + P  A+  + +FN +R  M +LP+ +     A V+L R+ + ++ +       N + + T D   N D A+ +   +FSW                     K E + +L NI+  + +G L+ + G VG+GK+SLIS+IL +MH ++GSVS  GT+AYVSQ+AWI + ++++NIL  + ++E  Y  +I AC LK DL  LP GD+TEIGERGINLSGGQKQRVSLARAVY NRDI+LLDDPLSAVDAHVG+H+FE  I     LK K+ ILVTH L +                         L+ C+E M      I+          G H    S L K K    QL  N                V +++N+    S                        E+++S     ++PK+  I  P    S  +  + ET +++     K   QLV  E A  G+V W TY   C  + G  L    V ++    G   FSN WL  + +     N+S +   N   IS +P  S        +Y ++Y +I + M ++      +FT  ++ +S  +H  + + +L SPM FFDTTP+GR++NRFSKD + +D ++P N+ + L    IV  +++ I  V P+  IA++ L +++  I   +  + R  +R+++++ SP  +  T T+QG++ I A+ K QQY +   + L D +S    +  +  RWLS  +++L   +     LF ++    ++  SL GL++SY++Q+T  L +++R  TE+E    ++ER+ EY +   SE    + +A  P+  WP  G ITFK+Y +RYR+  P+VL N+N+    G+K+G+VGRTG+GKSSL +ALFRL E A G+I+ID ++I  +GL DLR +L+++PQDPV+F GT+R NLDPF+++KD+E++ +LE  +++  +S L E L     E G N SV                      G++QL+C+ARALLR SK+++LDEATAS+D ETD L+ HTIR+ FQ  T++ IAHRINT+L++D I+VM+ G+++E D P++L+   + +F SL
Sbjct:   72 AGFFSFTSFSWMTPMMWRLFRNRL-DEDSLFLSPHDGAHINGERFQRLWDEEVA------RVGLEKASLSAV-------------------------IMRFQKTRFIVSFLASVMFAFAVFVGPSILVYEILNYVE-QSEPSTVVHGVGVCVALF-----LTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISLRS--LTTITVGETINVLTSDGYRLFDAVIFGTFLLCVPVLLIICIIYACFILGYTALIGILVYLIFLPIQFSIARLIGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSLNSSLTTIVPTLATIVTFIVH--TSLKLPLLPSTAYTIIAVFNCMRMSMGLLPFSVKAVAEAKVALTRLKRIMLVQ-------NPKGYLTQDK--NMDLALVMEKATFSWSPTDDKNTSQMPENPSQNGKHKAESQPSLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGTLAYVSQQAWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVSLARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECIKKE--LKGKSVILVTHQLQY-------------------------LEFCDEVMLLDNGEIKE--------AGTH----SDLMKTKGRYSQLITN----------------VHLEQNNERADSKPQT--------------------EHNDSEQTNPDEPKANGIENPAFDMSDEKPATNETPKDSSETKGKK-DQLVTREVAQEGSVTWRTYHQYCQAAGGYILLFLVVLLFTLLVGSTAFSNWWLSYWLDQGSGNNSSSNATSNSGNISENPDLS--------FYQMVYGVIIIAMIVLSILKGYTFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTICIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIERF-KMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSLFVVLSPNETINPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGPRRVKDANIPA-GWPQEGTITFKNYSMRYRDNTPIVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTILIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLPEKLQSPVVENGENFSV----------------------GERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPNSLFASL 1359

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:ZFIN;Acc:ZDB-GENE-050517-15])

HSP 1 Score: 546.969 bits (1408), Expect = 5.384e-168
Identity = 316/850 (37.18%), Postives = 481/850 (56.59%), Query Frame = 3

Query:  348 NSLIDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSS----FSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYD---KIKISHNRKRY-----------DLLQN-----------------STASVAHLMEDEDKLTNPDNRS-------------PGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDF--TDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESAL-GKAKNLLRQ 2744
             + +  +Y++S  +L +T++LA    +  R        ++  FWL   +   +     I+  L+  P ++           + L L++ +  C S     FS+   V+ +  PCPE  AS LSK+T+ W+   + K +++ + ++  + L  +D+S +    L + +     K+K S  R R+           DLLQN                 +  S       E K   P   S             P   LF +L R +G   L++  +K +HD  ++  P +L++L+ ++ + S   W GYF          L +L     F +  +  +R+R A++G +YRK L + N  R   T GEIVNLMSVDA+R M+ I +     S PLQ++LA+  L+Q +  ++ AG+ ++V   PLN ++    + +   ++K KD RIK++ E+LNGIKVLK+YAWE +F  K++ +R++E+R + +++    +    W   PFL+ L+TF  YVL  E NI+  +KAFVSL LFN+LRFP+ +LP  ++  + A VS++R+  +L  EEL+   +       T DS       I I DG+FSW K+D  TL  IN  I  G LVA+VG VG+GKSSL+SA+LGEMH+  GSVS++G++AYV Q+AWIQN +LK+NILF ++  + +Y+ ++EAC+L  DLE LPGGD TEIGE+G+NLSGGQKQRVS+ARAVY N  +YLLDDPLSAVDAHVG+H+FE VI   G+L+ +TR+LVTHGL++LP+ D +LV+  +G I+E GS+ +LL     F +F++ Y          S G  +  +    G    LLRQ
Sbjct:   99 GATVAPVYLVSPTMLGVTMLLATFLIQYERMKGVQSSGVMLNFWLITIVCATITFRSKIMHALN-DPASVGVFRYTTFYIYYTLLLISLILACLSDQPPLFSE---VVKDSNPCPESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRSDRRVRFLIVFSKTIKTVDLLQNWLILWLVYVFCARPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPS--LFFALCRTFGPYFLVSSLYKIIHDVLMFVGPEILRLLILFVNDSSAPTWHGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFLSHEELDDDNVERPAISGTPDS-------IRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVM-VDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAVPRKGLENGGPAALLRQ 934

HSP 2 Score: 222.631 bits (566), Expect = 4.193e-58
Identity = 138/394 (35.03%), Postives = 219/394 (55.58%), Query Frame = 3

Query: 2904 KYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSE 4085
            K  EN        +   S      G  +++     D    +      S+L E ++A +G VK + +   +K+ GL L I ++ ++       + SN WL  +T+D  + N                   + + +  + +Y  +G+   + V  Y  S +VG I AS+ +H+ +L +VLRSPM FF+ TPSG ++NRF+K+ + +D +IP  I   +  +F V  S  VI+  TP  AI I PL +LY+ +Q FY+ +SRQ +RL+S++ SPV+ HF ETL G ++IRAF EQQ F   +   +D + K  F    + RWL++R+E +G  +V  A LF+++ R +L+  ++GLSISY+LQ+T  LNWL+R  +ELETN VA+ER++EY     E
Sbjct:  921 KGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKANTGRVKLSVFWEYMKAIGLPLSIFSIFLFFCHHLSSLGSNYWLSLWTDDPVVNNT------------------QPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKE 1296

HSP 3 Score: 81.6481 bits (200), Expect = 6.962e-15
Identity = 79/299 (26.42%), Postives = 129/299 (43.14%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA--PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLA 4877
            LN L    + +    V+++R+R +    S  E D +N   P+ S   + +I   D    + +  P  LK IN+    G  + VVG  G+GKSSL  AL   +    GS+              ++  +  +PQ   I + TL++N+      KD    + +E   L   +  L  G   E GE GVNLS                       GQKQ + +ARA+     V +LD+  ++VD    + +   +   +   Q  T +++ H ++ +   D+I+VM +GEI E+ S   LL 
Sbjct:  631 LNMLPMVISSMVQASVSMQRLRVFL---SHEELDDDNVERPAISGTPD-SIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSV-------------SIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLS----------------------GGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVMVDGEITEMGSYTELLG 890

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202])

HSP 1 Score: 1021.92 bits (2641), Expect = 0.000e+0
Identity = 599/1531 (39.12%), Postives = 896/1531 (58.52%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXX------XXXMNFLTHCFSSFSKDRLVLPNKI-PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDES-TKNTNIL-----EKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFIS-LARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKN----PSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDK--PISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            +Y ++ +IL IT++ A + A+  R        +L IFW  AT+       C II        + R G +              L ++  L  CF         + ++I PCPE  A  LS+LT+ W        +++ + D+  + L   D S    TN++     EK    ++++S+++K   +L N T   A+    E  +   DN+ P    F+  L R +G   L+   FK   D   +  P LL IL+ +I+N+    W G+ +A+      ++ +L  +  F    +  +R+R+A+ G+IYRK+L + N  +   T GE+VNLMSVDA+R  +   F     S PLQI LA+  L+Q +  ++ AG+ ++V   P+N  +    + F   ++++KD RIK++ EILNGIKVLK+YAWE SF  K+  +R+ E+  + + +    +    W   PFL+ L TF  YV   E NI+  EKAFVSL+LFN+LRFP+ +LP  +++   A VS+KRI  +L  +EL+L  +     T D     +A I + +G+FSW K     L NIN  +  G LVA+VG+VG GKSSL+SA+LGEM +  G VSV+G++AYV Q+AWIQN +LK+NILF +  NEK Y+ ++EAC+L +DLE LPGGD+TEIGE+GINLSGGQKQRVSLARAV+ N D+YLLDDPLSAVDAHV +H+F+NVI  +G+L+ KTR+LVTHG+++LP+VD ++VL  +G ++E GS+++LLK    F +F++ Y   +   +     P   + L  E  L    +    L+DNE V  E     +   ++      SH +S                                              ++ R   K+  +N   L+ K  P  +L++ E   +G VK   +   +K+ GL + +    +Y+      + +N+WL ++T +  I    Q+                  T+  + +Y  +G+   L+V     S  +  I A++ +H  LL + + +P  F+DTTP GRIINRFSKDI  +D +IP  I   L+  F   +++IVI+  TP FA+ IIPLAI Y  +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+  Q  F  L+   +D++ K  +    S RWL +R+E +G  +V  A LF+++GR  L+  LVGLS+SY+LQ+T  LNW++R  ++LETN VA+ER++EY++  +EA W + +  P + WP+ G +   +Y +RYR GL LVLKN+NL  +GG+K+G+VGRTGAGKSS+ L LFR++E A G + ID +NIS IGL DLR RLTI+PQDPV+FSGTLR NLDPF+ + DDEI+++LE ++L+ +V+G    L+YEC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G I E D+P NL+A+  GIF
Sbjct:  104 VYFVTPLILGITMITATVLAQYERLRGVQSSGVLIIFWFLATV-------CAIIPFRSKVMASARQGQVTDKFRFTTFFLYFSLLVIELLLSCFKEARPFFSPVRDEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLAQMQVSYSKKPEAVL-NHTDEKAY----ESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNAV-----TKDKTLPGNA-ITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVL-VDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTD----LADNEPVANEARKKFIRQISILSDGEPSHAMS----------------------------------------------TRRRFTEKKPSEN---LVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQN------------------TQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSV----------------------GQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALK-GIF 1521

HSP 2 Score: 88.5817 bits (218), Expect = 1.018e-16
Identity = 78/315 (24.76%), Postives = 137/315 (43.49%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNNDL 4931
            LN L +  + L    V+++RI+ +    +  E DLN    D       IT  +    + +    +L+NINL    G  + VVG+ G GKSSL  AL   +E   G +              +R  +  +PQ   I + TL++N+    +  +    + LE   L + +  L  G   E GE G+NLS                       GQKQ + LARA+   + V +LD+  ++VD    + +   +       +  T +++ H I+ +   D IVV+ +G + E+ S + LL  +    + L + + ++++
Sbjct:  590 LNMLPQVISNLAQASVSIKRIQNFL---ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEV-------------SVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLS----------------------GGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEV 866

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202])

HSP 1 Score: 1002.66 bits (2591), Expect = 0.000e+0
Identity = 595/1534 (38.79%), Postives = 892/1534 (58.15%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXX------XXXMNFLTHCFSS----FSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDES-TKNTNIL-----EKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFIS-LARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKN----PSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDK--PISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            +Y ++ +IL IT++ A + A+  R        +L IFW  AT+       C II        + R G +              L ++  L  CF      FS  R  +    P  +    +L+    + L +Y     ++ + D+  + L   D S    TN++     EK    ++++S+++K   +L N T   A+    E  +   DN+ P    F+  L R +G   L+   FK   D   +  P LL IL+ +I+N+    W G+ +A+      ++ +L  +  F    +  +R+R+A+ G+IYRK+L + N  +   T GE+VNLMSVDA+R  +   F     S PLQI LA+  L+Q +  ++ AG+ ++V   P+N  +    + F   ++++KD RIK++ EILNGIKVLK+YAWE SF  K+  +R+ E+  + + +    +    W   PFL+ L TF  YV   E NI+  EKAFVSL+LFN+LRFP+ +LP  +++   A VS+KRI  +L  +EL+L  +     T D     +A I + +G+FSW K     L NIN  +  G LVA+VG+VG GKSSL+SA+LGEM +  G VSV+G++AYV Q+AWIQN +LK+NILF +  NEK Y+ ++EAC+L +DLE LPGGD+TEIGE+GINLSGGQKQRVSLARAV+ N D+YLLDDPLSAVDAHV +H+F+NVI  +G+L+ KTR+LVTHG+++LP+VD ++VL  +G ++E GS+++LLK    F +F++ Y   +   +     P   + L  E  L    +    L+DNE V  E     +   ++      SH +S                                              ++ R   K+  +N   L+ K  P  +L++ E   +G VK   +   +K+ GL + +    +Y+      + +N+WL ++T +  I    Q+                  T+  + +Y  +G+   L+V     S  +  I A++ +H  LL + + +P  F+DTTP GRIINRFSKDI  +D +IP  I   L+  F   +++IVI+  TP FA+ IIPLAI Y  +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+  Q  F  L+   +D++ K  +    S RWL +R+E +G  +V  A LF+++GR  L+  LVGLS+SY+LQ+T  LNW++R  ++LETN VA+ER++EY++  +EA W + +  P + WP+ G +   +Y +RYR GL LVLKN+NL  +GG+K+G+VGRTGAGKSS+ L LFR++E A G + ID +NIS IGL DLR RLTI+PQDPV+FSGTLR NLDPF+ + DDEI+++LE ++L+ +V+G    L+YEC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G I E D+P NL+A+  GIF
Sbjct:  107 VYFVTPLILGITMITATVLAQYERLRGVQSSGVLIIFWFLATV-------CAIIPFRSKVMASARQGQVTDKFRFTTFFLYFSLLVIELLLSCFKEARPFFSPVRDEIVRISPYFKKEVHLLAHTRLALLHSY-----KRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLAQMQVSYSKKPEAVL-NHTDEKAY----ESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNAV-----TKDKTLPGNA-ITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVL-VDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTD----LADNEPVANEARKKFIRQISILSDGEPSHAMS----------------------------------------------TRRRFTEKKPSEN---LVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQN------------------TQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSV----------------------GQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALK-GIF 1522

HSP 2 Score: 88.1965 bits (217), Expect = 1.117e-16
Identity = 78/315 (24.76%), Postives = 137/315 (43.49%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNNDL 4931
            LN L +  + L    V+++RI+ +    +  E DLN    D       IT  +    + +    +L+NINL    G  + VVG+ G GKSSL  AL   +E   G +              +R  +  +PQ   I + TL++N+    +  +    + LE   L + +  L  G   E GE G+NLS                       GQKQ + LARA+   + V +LD+  ++VD    + +   +       +  T +++ H I+ +   D IVV+ +G + E+ S + LL  +    + L + + ++++
Sbjct:  591 LNMLPQVISNLAQASVSIKRIQNFL---ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEV-------------SVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLS----------------------GGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEV 867

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202])

HSP 1 Score: 1000.73 bits (2586), Expect = 0.000e+0
Identity = 594/1535 (38.70%), Postives = 890/1535 (57.98%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXX------XXXMNFLTHCFSSFSKDRLVLPNKI-PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDES-TKNTNIL---EKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFIS-LARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLT-LN-----NINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKN----PSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDK--PISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            +Y ++ +IL IT++ A + A+  R        +L IFW  AT+       C II        + R G +              L ++  L  CF         + ++I PCPE  A  LS+LT+ W        +++ + D+  + L   D S    TN++   EK   + +++S+++K   +L N T   A+    E  +   DN+ P    F+  L R +G   L+   FK   D   +  P LL IL+ +I+N+    W G+ +A+      ++ +L  +  F    +  +R+R+A+ G+IYRK+L + N  +   T GE+VNLMSVDA+R  +   F     S PLQI LA+  L+Q +  ++ AG+ ++V   P+N  +    + F   ++++KD RIK++ EILNGIKVLK+YAWE SF  K+  +R+ E+  + + +    +    W   PFL+ L TF  YV   E NI+  EKAFVSL+LFN+LRFP+ +LP  +++   A VS+KRI  +L  +EL+L  +                   +D +   K E   + LN     NIN  +  G LVA+VG+VG GKSSL+SA+LGEM +  G VSV+G++AYV Q+AWIQN +LK+NILF +  NEK Y+ ++EAC+L +DLE LPGGD+TEIGE+GINLSGGQKQRVSLARAV+ N D+YLLDDPLSAVDAHV +H+F+NVI  +G+L+ KTR+LVTHG+++LP+VD ++VL  +G ++E GS+++LLK    F +F++ Y   +   +     P   + L  E  L    +    L+DNE V  E     +   ++      SH +S                                              ++ R   K+  +N   L+ K  P  +L++ E   +G VK   +   +K+ GL + +    +Y+      + +N+WL ++T +  I    Q+                  T+  + +Y  +G+   L+V     S  +  I A++ +H  LL + + +P  F+DTTP GRIINRFSKDI  +D +IP  I   L+  F   +++IVI+  TP FA+ IIPLAI Y  +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+  Q  F  L+   +D++ K  +    S RWL +R+E +G  +V  A LF+++GR  L+  LVGLS+SY+LQ+T  LNW++R  ++LETN VA+ER++EY++  +EA W + +  P + WP+ G +   +Y +RYR GL LVLKN+NL  +GG+K+G+VGRTGAGKSS+ L LFR++E A G + ID +NIS IGL DLR RLTI+PQDPV+FSGTLR NLDPF+ + DDEI+++LE ++L+ +V+G    L+YEC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G I E D+P NL+A+  GIF
Sbjct:   95 VYFVTPLILGITMITATVLAQYERLRGVQSSGVLIIFWFLATV-------CAIIPFRSKVMASARQGQVTDKFRFTTFFLYFSLLVIELLLSCFKEARPFFSPVRDEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLMQVSYSKKPEAVL-NHTDEKAY----ESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNAVT------------------KDKTLPGKDEGNCSDLNVIKCYNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVL-VDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTD----LADNEPVANEARKKFIRQISILSDGEPSHAMS----------------------------------------------TRRRFTEKKPSEN---LVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQN------------------TQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSV----------------------GQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALK-GIF 1504

HSP 2 Score: 79.337 bits (194), Expect = 6.452e-14
Identity = 77/316 (24.37%), Postives = 135/316 (42.72%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSD-SWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNNDL 4931
            LN L +  + L    V+++RI+ +    +  E DLN    D + P        D ++       +   NINL    G  + VVG+ G GKSSL  AL   +E   G +              +R  +  +PQ   I + TL++N+    +  +    + LE   L + +  L  G   E GE G+NLS                       GQKQ + LARA+   + V +LD+  ++VD    + +   +       +  T +++ H I+ +   D IVV+ +G + E+ S + LL  +    + L + + ++++
Sbjct:  579 LNMLPQVISNLAQASVSIKRIQNFL---ANDELDLNAVTKDKTLPGKDEGNCSDLNV-------IKCYNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEV-------------SVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLS----------------------GGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEV 849

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202])

HSP 1 Score: 999.964 bits (2584), Expect = 0.000e+0
Identity = 589/1525 (38.62%), Postives = 892/1525 (58.49%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXX------XXXMNFLTHCFSSFSKDRLVLPNKI-PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDES-TKNTNIL---EKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFIS-LARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDK--PISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            +Y ++ +IL IT++ A + A+  R        +L IFW  AT+       C II        + R G +              L ++  L  CF         + ++I PCPE  A  LS+LT+ W        +++ + D+  + L   D S    TN++   EK   + +++S+++K   +L N T   A+    E  +   DN+ P    F+  L R +G   L+   FK   D   +  P LL IL+ +I+N+    W G+ +A+      ++ +L  +  F    +  +R+R+A+ G+IYRK+L + N  +   T GE+VNLMSVDA+R  +   F     S PLQI LA+  L+Q +  ++ AG+ ++V   P+N  +    + F   ++++KD RIK++ EILNGIKVLK+YAWE SF  K+  +R+ E+  + + +    +    W   PFL+ L TF  YV   E NI+  EKAFVSL+LFN+LRFP+ +LP  +++   A VS+KRI  +L  +EL+L  +     T D            D +++   +    +++IN  +  G LVA+VG+VG GKSSL+SA+LGEM +  G VSV+G++AYV Q+AWIQN +LK+NILF +  NEK Y+ ++EAC+L +DLE LPGGD+TEIGE+GINLSGGQKQRVSLARAV+ N D+YLLDDPLSAVDAHV +H+F+NVI  +G+L+ KTR+LVTHG+++LP+VD ++VL  +G ++E GS+++LLK    F +F++ Y   ++  +       L++E+      +    L+DNE V  E     +   ++      SH +S                                              ++ R   K+  +N   L+ K  P  +L++ E   +G VK   +   +K+ GL + +    +Y+      + +N+WL ++T +  I    Q+                  T+  + +Y  +G+   L+V     S  +  I A++ +H  LL + + +P  F+DTTP GRIINRFSKDI  +D +IP  I   L+  F   +++IVI+  TP FA+ IIPLAI Y  +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+  Q  F  L+   +D++ K  +    S RWL +R+E +G  +V  A LF+++GR  L+  LVGLS+SY+LQ+T  LNW++R  ++LETN VA+ER++EY++  +EA W + +  P + WP+ G +   +Y +RYR GL LVLKN+NL  +GG+K+G+VGRTGAGKSS+ L LFR++E A G + ID +NIS IGL DLR RLTI+PQDPV+FSGTLR NLDPF+ + DDEI+++LE ++L+ +V+G    L+YEC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G I E D+P NL+A+  GIF
Sbjct:  124 VYFVTPLILGITMITATVLAQYERLRGVQSSGVLIIFWFLATV-------CAIIPFRSKVMASARQGQVTDKFRFTTFFLYFSLLVIELLLSCFKEARPFFSPVRDEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLMQVSYSKKPEAVL-NHTDEKAY----ESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNAV-----TKDKTLPGKDEGNCSDLNYTLHFKPFCFIHSINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVL-VDGRVTEMGSYQELLKQNGAFSEFLRNY-AFDDEVEEEDITILLAEETL-----STHTDLADNEPVANEARKKFIRQISILSDGEPSHAMS----------------------------------------------TRRRFTEKKPSEN---LVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQN------------------TQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSV----------------------GQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALK-GIF 1534

HSP 2 Score: 83.9593 bits (206), Expect = 2.499e-15
Identity = 80/319 (25.08%), Postives = 142/319 (44.51%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSD-SWP--NNGNITFKDYDLRYREGLPLV-LKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNNDL 4931
            LN L +  + L    V+++RI+ +    +  E DLN    D + P  + GN +  +Y L ++   P   + +INL    G  + VVG+ G GKSSL  AL   +E   G +              +R  +  +PQ   I + TL++N+    +  +    + LE   L + +  L  G   E GE G+NLS                       GQKQ + LARA+   + V +LD+  ++VD    + +   +       +  T +++ H I+ +   D IVV+ +G + E+ S + LL  +    + L + + ++++
Sbjct:  608 LNMLPQVISNLAQASVSIKRIQNFL---ANDELDLNAVTKDKTLPGKDEGNCSDLNYTLHFK---PFCFIHSINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEV-------------SVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLS----------------------GGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEV 885

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202])

HSP 1 Score: 971.459 bits (2510), Expect = 0.000e+0
Identity = 584/1527 (38.24%), Postives = 878/1527 (57.50%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPC-----PEVYASILSKLTYSWLDAYIYKW----FRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFIS-LARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKN----PSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDK--PISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            +Y ++ +IL IT++ A + A+  R        +L IFW  AT+       C II        + R G +               T  F  FS   LV+   + C     P    S +S+     +    ++     +++ + D+  + L   D S    N+   +  + IK     K+  L  N T   A+    E  +   DN+ P    F+  L R +G   L+   FK   D   +  P LL IL+ +I+N+    W G+ +A+      ++ +L  +  F    +  +R+R+A+ G+IYRK+L + N  +   T GE+VNLMSVDA+R  +   F     S PLQI LA+  L+Q +  ++ AG+ ++V   P+N  +    + F   ++++KD RIK++ EILNGIKVLK+YAWE SF  K+  +R+ E+  + + +    +    W   PFL+ L TF  YV   E NI+  EKAFVSL+LFN+LRFP+ +LP  +++   A VS+KRI  +L  +EL+L  +     T D            D +++   +    +++IN  +  G LVA+VG+VG GKSSL+SA+LGEM +  G VSV+G++AYV Q+AWIQN +LK+NILF +  NEK Y+ ++EAC+L +DLE LPGGD+TEIGE+GINLSGGQKQRVSLARAV+ N D+YLLDDPLSAVDAHV +H+F+NVI  +G+L+ KTR+LVTHG+++LP+VD ++VL  +G ++E GS+++LLK    F +F++ Y   +   +     P   + L  E  L    +    L+DNE V  E     +   ++      SH +S                                              ++ R   K+  +N   L+ K  P  +L++ E   +G VK   +   +K+ GL + +    +Y+      + +N+WL ++T +  I    Q+                  T+  + +Y  +G+   L+V     S  +  I A++ +H  LL + + +P  F+DTTP GRIINRFSKDI  +D +IP  I   L+  F   +++IVI+  TP FA+ IIPLAI Y  +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+  Q  F  L+   +D++ K  +    S RWL +R+E +G  +V  A LF+++GR  L+  LVGLS+SY+LQ+T  LNW++R  ++LETN VA+ER++EY++  +EA W + +  P + WP+ G +   +Y +RYR GL LVLKN+NL  +GG+K+G+VGRTGAGKSS+ L LFR++E A G + ID +NIS IGL DLR RLTI+PQDPV+FSGTLR NLDPF+ + DDEI+++LE ++L+ +V+G    L+YEC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G I E D+P NL+A+  GIF
Sbjct:  104 VYFVTPLILGITMITATVLAQYERLRGVQSSGVLIIFWFLATV-------CAIIPFRSKVMASARQGQVTDKFR---------FTTFFLYFS--LLVIELLLSCFKEARPHSCLSYISEYGVMMVCFVAFRMAILGYKRPLEDKDLWSLNEDDTS----NV---VVTNLIKEWEKEKKAVL--NHTDEKAY----ESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNAV-----TKDKTLPGKDEGNCSDLNYTLHFKPFCFIHSINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVL-VDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTD----LADNEPVANEARKKFIRQISILSDGEPSHAMS----------------------------------------------TRRRFTEKKPSEN---LVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAISVFICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQN------------------TQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKPPEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSV----------------------GQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALK-GIF 1499

HSP 2 Score: 83.5741 bits (205), Expect = 2.700e-15
Identity = 80/319 (25.08%), Postives = 142/319 (44.51%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSD-SWP--NNGNITFKDYDLRYREGLPLV-LKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNNDL 4931
            LN L +  + L    V+++RI+ +    +  E DLN    D + P  + GN +  +Y L ++   P   + +INL    G  + VVG+ G GKSSL  AL   +E   G +              +R  +  +PQ   I + TL++N+    +  +    + LE   L + +  L  G   E GE G+NLS                       GQKQ + LARA+   + V +LD+  ++VD    + +   +       +  T +++ H I+ +   D IVV+ +G + E+ S + LL  +    + L + + ++++
Sbjct:  567 LNMLPQVISNLAQASVSIKRIQNFL---ANDELDLNAVTKDKTLPGKDEGNCSDLNYTLHFK---PFCFIHSINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEV-------------SVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLS----------------------GGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEV 844

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676])

HSP 1 Score: 1022.69 bits (2643), Expect = 0.000e+0
Identity = 598/1525 (39.21%), Postives = 903/1525 (59.21%), Query Frame = 3

Query:  372 IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLL--DASPYNIRNGXXXXX-XXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILE---KIFYDKIKISHNRKRY----DLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLN-NAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++S  +L IT++LA    ++ RR       I+  FWL A +  L  L   II  L  DA     R+   +L    +    +++  + C   FS+    + ++ PCPE  AS LS++T+ W+   +   +R+ +     + L ++D S +   +L    K   DK +    R  Y    D  +   +S   + E+ + L   +   +R P   LF  L + +G   L++  +K +HD  ++A P +L++++ ++ +R    W GYF          L +LA +  F I  +  +RI+ A++G +YRK L + N  R   T GEIVNLMSVDA+R M+   +     S PLQ++LA+  L+  +  ++ AG+ +++   PLN ++    + +    +K KD RIK++ EILNGIKVLK+YAWE +F DK+ ++R  E++ + + +    V    W   PFL+ L+TF  +V   E NI+  +KAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    I  R            +I +++ +F+W + +  TLN I F I  G LVA+VG+VG GKSSL+SA+L EM ++ G V+++G++AYV Q+AWIQN SL+ENILF     E +Y+ ++EAC+L  DLE LP GD TEIGE+G+NLSGGQKQRVSLARAVY N DIYL DDPLSAVDAHVG+H+FE V+   G+LK+KTRILVTHG+++LP+VD ++V+ S G ISE GS+++LL     F +F++ Y        N        D+S  G  K         E    E    V  +    +QR+    +SN+                       +S+SG    +      +   G++         + T +L++   +Q        +G V+ + Y   +K+ GL++   ++ ++       + SN WL  +T+D  + N +Q                     + + +Y  +G+     +  Y  + ++G I AS+ +H  LL +VLRSPM FF+ TPSG ++NRFSK+++ +D +IP  I   +  LF V  ++I+I+  TP  A+ I PL ++Y+ +Q FY+ +SRQ +RL+S++ SPV++HF ETL GV++IRAF+EQ+ F + +   +D++ K  +    + RWL++R+E +G  +V  A LF++I R SL+A LVGLS+SYSLQIT +LNWL+R  +E+ETN VA+ER++EYS+   EA W +   AP  +WP++G + F+DY LRYRE L LVLK+IN+   GG+K+G+VGRTGAGKSSL L LFR+ E+A G IIID +NI+ IGLH+LR ++TI+PQDPV+FSG+LR NLDPFS + D+E++ +LE AHL+ +VS L + L++EC EGG NLSV                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ GE+ E  +P  LL    GIF S+
Sbjct:  107 LVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSE---TVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPS--LFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEG----NSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVM-SGGKISEMGSYQELLDRDGAFAEFLRTY-------ANAEQDLASEDDSVSGSGK---------ESKPVENGMLVTDTVGKHLQRH----LSNS-----------------------SSHSGDTSQQHSSIAELQKAGAK---------EETWKLMEADKAQ--------TGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQ-----------------ANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSV----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELL-QQRGIFYSM 1521

HSP 2 Score: 90.8929 bits (224), Expect = 1.203e-17
Identity = 75/275 (27.27%), Postives = 128/275 (46.55%), Query Frame = 3

Query: 1863 VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            V+++R+ +Y   E+    +I  ++    S + +   +E RD    ++++  L L +IN  I  G+ V IVG+ G GKSSL   +        G + + G              I  + Q+  + + SL+ N+     Y+++     +E   LK  +  LP     E  E G NLS GQ+Q V LARA+ +   I +LD+  +AVD     +L ++ I      +D T + + H LN +     V+VLD  G + E G+  +LL+    F    ++
Sbjct: 1256 VAVERLKEYSETEKEAPWQI--QETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DNLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVLD-KGEVRECGAPSELLQQRGIFYSMAKD 1524

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658])

HSP 1 Score: 1013.06 bits (2618), Expect = 0.000e+0
Identity = 584/1520 (38.42%), Postives = 897/1520 (59.01%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDAS----PYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKI---PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDK-LTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            ++ ++ +++ IT++LA L  +  R        +L IFWL   I  ++     I+  L       P+             F L     +  CF    K  L  P  +   PCPE  A   S+L++ W        +R+ + D   + L  +D S K   +++++     K  +   R     + TA+    +  ED  L  P  +S       +L R +   LL++  F  + +   +  P LL IL+ +I + +   W G+ LA        + +L  +  +    ++++R+R A+IG+IYRK L + N ++ + T GE+VNLMSVDA+R M+   F     S PLQ++LAI  L+Q +  +  AG+ +IV   PLNG +   M+ +   ++K+KD RIK+++EILNGIKVLK+YAWE SFL+++  +R +E++ + + +    +   +W   PFL+ L T   YV   E N++  EKAFVSL+LFN+L+ P+ +LP  ++    A VSLKRI  +L   EL+   +  +  +   A      I I +G+F+W ++   TL+++N +I +G LVA+VG VG GKSSL+SA+LGEM ++ G VSV+G++AYV Q+AWIQN +L+EN+LF Q  N K Y+  +E C+L +DL+ LPGGD+TEIGE+GINLSGGQ+QRVSLARAVY + +I+LLDDPLSAVD+HV +H+F+ VI   G+L  KTR+LVTHG+++LP+ D ++VL + G +SE G +  LL+    F  F++ Y    ++  + +  Q+ ++E  L             ED +   TD     PA+   R    R  ++                        S+ G  ++      R M P   +  + KE          K    L++EE A +G VK + Y    KS GL   ++   +Y   +   + +N+WL  ++ D++ ++  Q+                 +T   + +Y  +G+   L+V     +  VG+I A++++H+ LL + +RSP  FFDTTPSGRI+NRFSKDI  +D ++   I   L+  F   ++I+VI+  TP F + ++PLA+LY  +Q FY+ TSRQ +RL+SI+ SP+F+HF+ET+ G ++IRA+   Q F+ L+ T +D + K  +   +S RWL + +E +G  +V  A LF++IGR SL   LVGLS+SY+LQ+T  LNW++R  ++LE+N +A+ER++EYSK  +EA W  + N AP + WP  G + F++Y +RYR GL LVLKN+ +H  GG+K+G+VGRTGAGKSS+ L LFR++EAA G I+ID +N++ IGLHDLR +LTI+PQDP++FSGTLR NLDPF  + +++I+++LE +HL ++VS    GLD++C EGG NLSV                      GQ+QL+CLARALLRKS+VL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D + ++V++ G + E DSP NL+A + GIF
Sbjct:  104 VFFVTPLVVGITMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTT-----FYIYFALVFCALILSCFKE--KPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHK---VVQRLLEAWQKQQNQASR-----SQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGYA------ITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-AGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLL------------LEDTLSTHTDLTDNEPAIYEVRKQFMREMSSL-----------------------SSEGEVQN------RTM-PKKHTNSLEKEALVTK----TKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAE-EHGQQN-----------------KTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAP-EGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSV----------------------GQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIF 1513

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658])

HSP 1 Score: 1011.91 bits (2615), Expect = 0.000e+0
Identity = 586/1520 (38.55%), Postives = 895/1520 (58.88%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDAS----PYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKI---PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDK-LTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            ++ ++ +++ IT++LA L  +  R        +L IFWL   I  ++     I+  L       P+             F L     +  CF    K  L  P  +   PCPE  A   S+L++ W        +R+ + D   + L  +D S K   +++++     K  +   R     + TA+    +  ED  L  P  +S       +L R +   LL++  F  + +   +  P LL IL+ +I + +   W G+ LA        + +L  +  +    ++++R+R A+IG+IYRK L + N ++ + T GE+VNLMSVDA+R M+   F     S PLQ++LAI  L+Q +  +  AG+ +IV   PLNG +   M+ +   ++K+KD RIK+++EILNGIKVLK+YAWE SFL+++  +R +E++ + + +    +   +W   PFL+ L T   YV   E N++  EKAFVSL+LFN+L+ P+ +LP  ++    A VSLKRI  +L   EL+   +  +  +   A      I I +G+F+W ++   TL+++N +I +G LVA+VG VG GKSSL+SA+LGEM ++ G VSV+G++AYV Q+AWIQN +L+EN+LF Q  N K Y+  +E C+L +DL+ LPGGD+TEIGE+GINLSGGQ+QRVSLARAVY + +I+LLDDPLSAVD+HV +H+F+ VI   G+L  KTR+LVTHG+++LP+ D ++VL + G +SE G +  LL+    F  F++ Y    ++           D  AL  A   +  L   ED +   TD     PA+   R    R  ++                        S+ G  ++      R M P   +  + KE          K    L++EE A +G VK + Y    KS GL   ++   +Y   +   + +N+WL  ++ D++ ++  Q+                 +T   + +Y  +G+   L+V     +  VG+I A++++H+ LL + +RSP  FFDTTPSGRI+NRFSKDI  +D ++   I   L+  F   ++I+VI+  TP F + ++PLA+LY  +Q FY+ TSRQ +RL+SI+ SP+F+HF+ET+ G ++IRA+   Q F+ L+ T +D + K  +   +S RWL + +E +G  +V  A LF++IGR SL   LVGLS+SY+LQ+T  LNW++R  ++LE+N +A+ER++EYSK  +EA W  + N AP + WP  G + F++Y +RYR GL LVLKN+ +H  GG+K+G+VGRTGAGKSS+ L LFR++EAA G I+ID +N++ IGLHDLR +LTI+PQDP++FSGTLR NLDPF  + +++I+++LE +HL ++VS    GLD++C EGG NLSV                      GQ+QL+CLARALLRKS+VL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D + ++V++ G + E DSP NL+A + GIF
Sbjct:  104 VFFVTPLVVGITMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTT-----FYIYFALVFCALILSCFKE--KPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHK---VVQRLLEAWQKQQNQASR-----SQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGYA------ITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-AGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQ----------EDHEALQNANEEVLLL---EDTLSTHTDLTDNEPAIYEVRKQFMREMSSL-----------------------SSEGEVQN------RTM-PKKHTNSLEKEALVTK----TKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAE-EHGQQN-----------------KTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAP-EGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSV----------------------GQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIF 1512

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:MGI Symbol;Acc:MGI:1352447])

HSP 1 Score: 969.148 bits (2504), Expect = 0.000e+0
Identity = 574/1432 (40.08%), Postives = 864/1432 (60.34%), Query Frame = 3

Query:  675 CPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHN--RKRYDLLQNSTASVAHLM-----EDEDKLTNPDNRS-----------PGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNED-------VVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLW--LFIATVAI--YAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLC--MTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLA 4877
             P   AS LS +T+SW D+ + K ++  +T E  +D+    ++   T+  + I    ++ +    ++R    Q S    +H +     + +D L   D++            P   L  +L + + + +L +   K  HD  ++  P LLK L+ ++++     W+GY  AI      ++ S      F    +L + +R  +I  +Y+K L L+N  R ++T GE VNLMSVD++++M+   +     S  LQI L+I  L++E+  +I AG+GL+V   P+NG+L   ++K     +K KD R+KI+ EIL+GIK+LK +AWE SF +++ ++R  E+R +LR S    ++  +  + P L+ + TF  YVL    N++  EKAF S+TLFN+LRFP+ +LP  ++  + A VS+ R+ QYL  ++L+L+ I H         ++D A++  + SF+W ++ + T+ ++N +I  G+LVA+VG VG+GKSSLISA+LGEM  ++G ++++G+IAYV Q+AWIQN ++K+NILF  +Y+EK Y+ +IEAC+L  DLE LPGGD  EIGE+GINLSGGQK RVSLARA YQ+ DIY+LDDPLSAVD HVG+H+F  V+  NG+L  KTRILVTHG+++LP+VDE++VL   G+I E+GS+ DL+     F +  + +++H+     P G   + ++             S+ ED        VEEI D    + ++ ++R +S R + +    S S        S  +K     N                         KE      +LI K   + VE     +G VK++ Y   +++ G W  LFI    +  Y AF G    +N+WL  +T DS+ QN + +       SP        Q    + ++  +G+   + L+    W+ +     NASK +H++LL ++LR+PM FFDTTP+GRI+NRF+ DI  +D  +P  +   L C F + +++++I   TP F I IIPL+ILY  +Q+FY+ TSRQ RRLDS+  SP+++HF+ET+ G+ +IRAF+ QQ F   ++  ID + K  F   +S RWL++R+E++G L+VF + L  +I + SLT   VG  +S +L IT+ LNWL+R  +E+ETN VA+ERI EY  + +EA W  +  P   WP  G I F +Y +RYR  L LVLK I  +    +K+GVVGRTGAGKSSL   LFR++E+AGG IIID I+I++IGLHDLR RLTI+PQDP++FSG LR NLDPF+ + D+EI+++LE AHL+S+V+GL  GL +E  EGG NLS+                      GQ+QLLCL RA+LRKSK+L+LDEATA+VD+ETD L+  TIR  F   TVI IAHR++TI+D+D I+V+++G+IVE  SP+ LL+
Sbjct:  192 APSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSYPWVGYIYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLGSDDLDLSAIRH-------VCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVL-GKGTILEKGSYSDLMDKKGVFAKNWKTFMKHS----GPEGEATVDND-------------SEEEDGDCGLIPTVEEIPD---DAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALN------------------------KKEEVVKGQKLIKK---EFVE-----TGKVKFSIYLKYLQAVGWWSLLFIVIFYVLNYVAFIG----TNLWLSAWTSDSEKQNGTDN-------SP-------SQRDMRIGVFGALGIAQGIFLLSSSLWSIYACR--NASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSI----------------------GQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLS 1521

HSP 2 Score: 78.9518 bits (193), Expect = 5.815e-14
Identity = 94/387 (24.29%), Postives = 168/387 (43.41%), Query Frame = 3

Query: 1548 TEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGL---TDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYD----AAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRIN-------------GSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            +E ++G+ V++ +  ++ FL       DT  + +     +   + +  E++  LI+  + L  V+    N +T +   V   L N L      L W +   ++     V+++RI +Y+  +       N   +  D     D      I+  +    ++ E  L L  I   I   + V +VG+ G GKSSL + +   +                 G   ++G +  + Q+  + + +L+ N+     Y+++     +E   LKS +  L  G   E+ E G NLS GQ+Q + L RAV +   I +LD+  +AVD      L +  I N       T I + H L+ +   D+++VLDS G I E GS ++LL +   F    +E
Sbjct: 1162 SETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYK--NSLTGDT--VGFVLSNALNITQT-LNWLVRMTSEVETNIVAVERINEYINVD-------NEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLET-DSLIQTTIRNE--FSQCTVITIAHRLHTIMDSDKIMVLDS-GKIVEYGSPEELLSNMGPFYLMAKE 1532

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc12 (ATP-binding cassette, sub-family C (CFTR/MRP), member 12 [Source:MGI Symbol;Acc:MGI:2441679])

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 465/1454 (31.98%), Postives = 749/1454 (51.51%), Query Frame = 3

Query:  672 PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNY-WIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEE-----------------LNLT-----EINHRD------------FTDDSAFNYDAAIEIRDG--SFSWKK-EDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLF-IATVAIYAAFTGLQVFSNIWLKNFTE-DSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREY--SKIPSEAE-WDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            P P   A +LS  T+SWL   + + ++  +T +T   L   D S  N                  KR+ +L           E+E K   P+  S G V++    R   L  ++A     V   +      L+  +L++I + S  +  IG  L +A         L     + I    +IR++ AL  +I+   L          ++GE++N++S D+  +    +F     + P+ +V+  +  +  +      G+ + + F P+   +  L   F    +   D R++ + E L  IK++KMYAWE+SF++ I ++R  E + + +          L  I+  + +++TF C++       +T   AF  + +FN+++F + +LP+ +     A VSL+R+ + L+ +                   N T     EIN +             F       Y        G  S  W+    K  L+NI+F + +GK++ I G VG+GKSSLISA+LG+M    G V+V G +AYVSQ+AWI + +++ENILF + YN + Y+  +  C L+ DL  LP GD TEIGERG+NLSGGQ+QR+SLARAVY NR +YLLDDPLSAVDAHVG+H+FE  I     LK KT +LVTH L +L   DEV++L+ +G I E+G+ K+L+++   + + +     HN R       +H+                  N  +VE + +    SPA   QR++   +++                               E ++ K P              ET++  D   + P  QL++ E    G V W TY   IK+ G +L     + ++    G   FS  WL  + +  S +  ASQ+   N +       +   +   Y ++Y    + + +       +FT  ++ AS  +H ++   ++RSPM FFDTTP+GR++NRFSKD++ LD  +P +  + L   F+V   ++++  V P   + +  LA+++ ++   +    ++ +++++I+ SP F+H T ++QG+ +I A+ ++    +  +TL D++S        ++RW +LR++IL  ++ F   L   +   S++AS  GLS+SY +Q++  L   +R  TE +    + E +REY  + +P     + +   P D WP+ G ITFKDY +RYR+  PLVL  +NL+   G+ +G+VGRTG+GKSSL +ALFRLVE A G+IIID+++I T+GL DLR +LT++PQDPV+F GT+R NLDP  SH D+ ++  LE   ++  +  L E L  E  E G N SV                      G++QLLC+ARALLR SK+++LDEATAS+D +TD LV  TI+E F++ TV+ IAHR+NT+L+ D+++VMENG+++E D P+ L    D  F  L
Sbjct:   43 PNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINA-----------------KRFQIL----------WEEEIKRVGPEKASLGRVVW-KFQRTRVLMDVVANILCIV--MAALGPTVLIHQILQHITSISSGHIGIGICLCLALFTTEFTKVLFWALAWAINYRTAIRLKVALSTLIFENLLSFKT--LTHISAGEVLNILSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFILGSTALVGISVYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREKKLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLKRK--LTAPVAFSVIAMFNVMKFSIAILPFSVKAVAEASVSLRRMKKILIAKSPPSYITQPEDPDTILLLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPELYSEQSRSDQGVASPEWQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKT--LKGKTVVLVTHQLQFLESCDEVILLE-DGEICEKGTHKELMEERGRYAKLI-----HNLRGLQFKDPEHIY-----------------NVAMVETLKE----SPA---QRDEDAVLASGD-----------------------------EKDEGKEP--------------ETEEFVD--TNAPAHQLIQTESPQEGIVTWKTYHTYIKASGGYLVSFLVLCLFFLMMGSSAFSTWWLGIWLDRGSQVVCASQN---NKTACNVDQTLQDTKHHMYQLVYIASMVSVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVENISRSPWFSHITSSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLSFSSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYILTCVPEHTHPFKVGTCPKD-WPSRGEITFKDYRMRYRDNTPLVLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSV----------------------GERQLLCMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKPEVLAEKPDSAFAML 1359

HSP 2 Score: 80.8777 bits (198), Expect = 1.607e-14
Identity = 65/250 (26.00%), Postives = 111/250 (44.40%), Query Frame = 3

Query: 4167 YREGLPL-VLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMH-TIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHD 4910
            ++ G P  VL NI+     GK +G+ G  G+GKSSL  AL   ++                G+  +   L  + Q   IF G +REN+     +       ++    LQ  ++ L  G   E GE GVNLS                       GQ+Q + LARA+    ++ +LD+  ++VD    + V    I++  +  TV+++ H++  +   D ++++E+GEI E  + K L+       K +H+
Sbjct:  488 WQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQ-------------LQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLS----------------------GGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHN 702

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BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q8CG09|MRP1_RAT (Multidrug resistance-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Abcc1 PE=1 SV=2)

HSP 1 Score: 1041.18 bits (2691), Expect = 0.000e+0
Identity = 614/1537 (39.95%), Postives = 916/1537 (59.60%), Query Frame = 3

Query:  354 LIDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLL--DASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFS---KDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKR---------YDLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAV--PIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLN-NAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            L+  + ++S  +L IT++LA    +  RR       I+  FWL A +  L  L   II  L  DA     R+   +L   + F   +  +  CFS  S    + +  PN  PCPE  AS LS++T+ W+   + + +R+ +     + L ++D S +   +L   +  K +   +RK+          D  +   +S   + E+ + L   ++  +R P   LF  L + +G   L++  +K +HD  ++A P +L++++ ++ +R    W GY           L +LA +  F I  +  +RI+ A++G +YRK L + N  R   T GEIVNLMSVDA+R M+   +     S PLQ+ LA+  L+  +  ++ AG+ +++   P N ++    + +    +K KD RIK++ EILNGIKVLK+YAWE +F DK+ N+R  E++ + + +    V    W   PFL+ L+TF  +V   E NI+  +KAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    I      D    N   +I +++ +F+W +++  TLN I F I  G LVA+VG+VG GKSSL+SA+L EM ++ G V+++G++AYV Q+AWIQN SL+ENILF +   E  Y+ ++EAC+L  DLE LP GD TEIGE+G+NLSGGQKQRVSLARAVY N DIYLLDDPLSAVDAHVG+H+FE V+   G+LK+KTRILVTHG+++LP+VD ++V+ S G ISE GS+++LL     F +FV+ Y             Q L+ E     +KN +  L      VE   + +L + AV  P+QR+ S+  S++           +    +H    E   SGV E+                                   +L+E ++A +G VK + Y   +K+ GL +   ++ ++       + SN WL  +T+D    N +Q                 E   + + +Y  +G+   + V  Y  + ++G I AS+ +H  LL++VLRSPM FF+ TPSG ++NRFSK+++ +D +IP  I   +  LF V  ++I+I+  TP  A+ I PL ++Y+ +Q FY+ +SRQ +RL+S++ SPV++HF ETL GV++IRAF+EQ+ F   +   +D++ K  +    + RWL++R+E +G  +V  A LF++I R SL+A LVGLS+SYSLQIT +LNWL+R  +E+ETN VA+ER++EYS+   EA W +   AP  +WP++G + F+DY LRYRE L LVLK+IN+   GG+K+G+VGRTGAGKSSL L LFR+ E+A G IIID INI+ IGLH+LR ++TI+PQDPV+FSG+LR NLDPFS + D+E++ +LE AHL+ +VS L + L++EC EGG NLSV                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+ STV+ IAHR+NTI+D   ++V++ GEI E  +P  LL    G+F S+
Sbjct:  101 LLAPVLLVSPTLLGITMLLATFLIQFERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFTLVF---IQLVLSCFSDSSPLFSETVRDPN--PCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNW--KKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPS--LFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMN---SITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVM-SGGKISEMGSYQELLDRDGAFAEFVRTYANTE---------QDLASED---DSKNGVSGLGKESKPVE---NGILVTDAVGKPLQRHLSNSSSHS-----------VVTNQQHSSTAELQKSGVKEE---------------------------------TWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQ-----------------ENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSV----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELL-QQRGVFYSM 1525

HSP 2 Score: 91.6633 bits (226), Expect = 5.811e-17
Identity = 76/275 (27.64%), Postives = 127/275 (46.18%), Query Frame = 3

Query: 1863 VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQG-------------TIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            V+++R+ +Y   E+    +I  ++    S + +   +E RD    ++++  L L +IN  I  G+ V IVG+ G GKSSL   +        G + + G              I  + Q+  + + SL+ N+     Y+++     +E   LK  +  LP     E  E G NLS GQ+Q V LARA+ +   I +LD+  +AVD      L ++ I      +D T + + H LN +     V+VLD  G I E G+  +LL+    F    ++
Sbjct: 1260 VAVERLKEYSETEKEASWQI--QETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQ--FEDSTVLTIAHRLNTIMDYTRVIVLD-KGEIRECGAPSELLQQRGVFYSMAKD 1528

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q6UR05|MRP1_CANLF (Multidrug resistance-associated protein 1 OS=Canis lupus familiaris OX=9615 GN=ABCC1 PE=1 SV=1)

HSP 1 Score: 1038.87 bits (2685), Expect = 0.000e+0
Identity = 615/1530 (40.20%), Postives = 913/1530 (59.67%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLL--DASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKI-----PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRY------DLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNN-APSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++++S  +L IT++LA    ++ RR       I+  FWL A +  L  L   I+  L  DA     R+         F L L+  +  CFS    DR  L ++      PCPE  AS LS++T+ W+   + + +R+ +     + L ++D S +   +L K +  +   S  ++R       D  +    S   + E+ + L   T    R P   LF  L + +G   L++  FK +HD  ++A P +LK+L+ ++ ++    W GY           L +L  +  F I  +  +RI+ A+IG +YRK L + N  R   T GEIVNLMSVDA+R M+   +     S PLQ++LA+ LL+  +  ++ AG+ +++   PLN ++    + +    +K KD RIK++ EILNGIKVLK+YAWE +F DK+  +R  E++ + + +    V    W   PFL+ L+TF  YV   + NI+  +KAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    I  R   D    N   +I +++ +F+W + D  TL+ I F I  G LVA+VG+VG GKSSL+SA+L EM ++ G V+++G++AYV Q+AWIQN SL+ENILF +   E++Y+ +IEAC+L  DLE LP GD TEIGE+G+NLSGGQKQRVSLARAVY + DIYL DDPLSAVDAHVG+H+FENVI   G+LK+KTR+LVTH +++LP+VD ++V+ + G ISE GS+++LL     F +F++ Y   +        G  L+  S+ GK    ++Q+ +N  +V ++           +QR                               + SNS  +  +      +    + + ++ K   +N D        +LVE ++A +G VK + Y   +K+ GL++   ++ ++       + SN WL  +T+D  I N +Q                 E TK  + +Y  +G+   + V  Y  + ++G I AS+ +H  LL++VLRSPM FF+ TPSG ++NRFSK+++ +D +IP  I   +  LF V  + I+I+  TP  +I I PL ++Y+ +Q FY+ +SRQ +RL+S++ SPV++HF ETL GV++IRAF+EQ+ F   +   +D++ K  +    + RWL++R+E +G  +V  A LFS+I R SL+A LVGLS+SYSLQ+T +LNWL+R  +E+ETN VA+ER++EYS+   EA W +   AP  +WP  G + F+DY LRYRE L LVLK+IN+  +GG+K+G+VGRTGAGKSSL L LFR+ E+A G IIID INI+ IGLHDLR ++TI+PQDPV+FSG+LR NLDPFS + D+E++ SLE AHL+ +VSGL + L+ EC EGG NLSV                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F   TV+ IAHR+NTI+D   ++V++ GEI E   P +LL    G+F S+
Sbjct:  105 VFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLIALLCALAILRSKIMTALKEDAEIDVFRD---VTFYIYFSLVLIQLVLSCFS----DRPPLFSETIHDLNPCPESSASFLSRVTFWWITGLMVRGYRQPLESTDLWSLNKEDTSEQVVPVLVKNWKKECAKSKRQQRKITYSSKDPAKPKGGSQVDVNEEAEVLIVKTPQKEREPS--LFKVLYKTFGPYFLMSFLFKALHDLMMFAGPEILKLLINFVNDKKAPDWQGYLYTALLFICACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGAN---SITVKNATFTWARSDPPTLSGITFSIPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGRQLQERYYKAVIEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRLLVTHSISYLPQVDVIIVM-TGGKISEMGSYQELLARDGAFAEFLRTYASGDQEQAEQDDG--LTGVSSPGKE---VKQM-ENGMLVTDVA-------GKQLQR-------------------------------QLSNSSSYSGD------VSRHHTSTAELQKAGPKNEDAW------KLVEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTDDP-IVNGTQ-----------------EHTKIRLSVYGALGISQGITVFGYSMAVSIGGIFASRRLHVDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPIASIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFSVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQEMAPPSTWPQVGRVEFRDYGLRYRENLDLVLKHINITINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDDINIAKIGLHDLRVKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSGLPDKLNQECAEGGENLSV----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIRECGQPSDLL-QQRGLFYSM 1524

HSP 2 Score: 87.4261 bits (215), Expect = 1.050e-15
Identity = 83/280 (29.64%), Postives = 130/280 (46.43%), Query Frame = 3

Query: 1863 VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVS-----------------VQGTIAYVSQEAWIQNKSLKENI-LFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            V+++R+ +Y   E+    +I  ++    S +     +E RD    +++   L L +IN  I  G+ V IVG+ G GKSSL    LG + RIN S                   ++  I  + Q+  + + SL+ N+  F+Q  +E+ +  + E   LK  +  LP     E  E G NLS GQ+Q V LARA+ +   I +LD+  +AVD      L ++ I       D T + + H LN +     V+VLD  G I E G   DLL+    F    ++
Sbjct: 1259 VAVERLKEYSETEKEAPWQI--QEMAPPSTWPQVGRVEFRDYGLRYRENLDLVLKHINITINGGEKVGIVGRTGAGKSSLT---LG-LFRINESAEGEIIIDDINIAKIGLHDLRVKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSL-ELAHLKDFVSGLPDKLNQECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQ--FDDCTVLTIAHRLNTIMDYTRVIVLD-KGEIRECGQPSDLLQQRGLFYSMAKD 1527

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|O35379|MRP1_MOUSE (Multidrug resistance-associated protein 1 OS=Mus musculus OX=10090 GN=Abcc1 PE=1 SV=1)

HSP 1 Score: 1022.69 bits (2643), Expect = 0.000e+0
Identity = 598/1525 (39.21%), Postives = 903/1525 (59.21%), Query Frame = 3

Query:  372 IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLL--DASPYNIRNGXXXXX-XXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILE---KIFYDKIKISHNRKRY----DLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLN-NAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++S  +L IT++LA    ++ RR       I+  FWL A +  L  L   II  L  DA     R+   +L    +    +++  + C   FS+    + ++ PCPE  AS LS++T+ W+   +   +R+ +     + L ++D S +   +L    K   DK +    R  Y    D  +   +S   + E+ + L   +   +R P   LF  L + +G   L++  +K +HD  ++A P +L++++ ++ +R    W GYF          L +LA +  F I  +  +RI+ A++G +YRK L + N  R   T GEIVNLMSVDA+R M+   +     S PLQ++LA+  L+  +  ++ AG+ +++   PLN ++    + +    +K KD RIK++ EILNGIKVLK+YAWE +F DK+ ++R  E++ + + +    V    W   PFL+ L+TF  +V   E NI+  +KAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    I  R            +I +++ +F+W + +  TLN I F I  G LVA+VG+VG GKSSL+SA+L EM ++ G V+++G++AYV Q+AWIQN SL+ENILF     E +Y+ ++EAC+L  DLE LP GD TEIGE+G+NLSGGQKQRVSLARAVY N DIYL DDPLSAVDAHVG+H+FE V+   G+LK+KTRILVTHG+++LP+VD ++V+ S G ISE GS+++LL     F +F++ Y        N        D+S  G  K         E    E    V  +    +QR+    +SN+                       +S+SG    +      +   G++         + T +L++   +Q        +G V+ + Y   +K+ GL++   ++ ++       + SN WL  +T+D  + N +Q                     + + +Y  +G+     +  Y  + ++G I AS+ +H  LL +VLRSPM FF+ TPSG ++NRFSK+++ +D +IP  I   +  LF V  ++I+I+  TP  A+ I PL ++Y+ +Q FY+ +SRQ +RL+S++ SPV++HF ETL GV++IRAF+EQ+ F + +   +D++ K  +    + RWL++R+E +G  +V  A LF++I R SL+A LVGLS+SYSLQIT +LNWL+R  +E+ETN VA+ER++EYS+   EA W +   AP  +WP++G + F+DY LRYRE L LVLK+IN+   GG+K+G+VGRTGAGKSSL L LFR+ E+A G IIID +NI+ IGLH+LR ++TI+PQDPV+FSG+LR NLDPFS + D+E++ +LE AHL+ +VS L + L++EC EGG NLSV                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ GE+ E  +P  LL    GIF S+
Sbjct:  107 LVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSE---TVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPS--LFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEG----NSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVM-SGGKISEMGSYQELLDRDGAFAEFLRTY-------ANAEQDLASEDDSVSGSGK---------ESKPVENGMLVTDTVGKHLQRH----LSNS-----------------------SSHSGDTSQQHSSIAELQKAGAK---------EETWKLMEADKAQ--------TGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQ-----------------ANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSV----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELL-QQRGIFYSM 1521

HSP 2 Score: 90.8929 bits (224), Expect = 8.417e-17
Identity = 75/275 (27.27%), Postives = 128/275 (46.55%), Query Frame = 3

Query: 1863 VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            V+++R+ +Y   E+    +I  ++    S + +   +E RD    ++++  L L +IN  I  G+ V IVG+ G GKSSL   +        G + + G              I  + Q+  + + SL+ N+     Y+++     +E   LK  +  LP     E  E G NLS GQ+Q V LARA+ +   I +LD+  +AVD     +L ++ I      +D T + + H LN +     V+VLD  G + E G+  +LL+    F    ++
Sbjct: 1256 VAVERLKEYSETEKEAPWQI--QETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DNLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVLD-KGEVRECGAPSELLQQRGIFYSMAKD 1524

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BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|B2RX12|MRP3_MOUSE (Canalicular multispecific organic anion transporter 2 OS=Mus musculus OX=10090 GN=Abcc3 PE=1 SV=1)

HSP 1 Score: 1010.75 bits (2612), Expect = 0.000e+0
Identity = 581/1520 (38.22%), Postives = 899/1520 (59.14%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDAS----PYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKI---PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDK-LTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            ++ ++ +++ IT++LA L  +  R        +L IFWL   I  ++     I+  L       P+             F L     +  CF    K  L  P  +   PCPE  A   S+L++ W        +R+ + D   + L  +D S K   +++++       +  +++     + TA+    +  ED  L  P  +S       +L R +   LL++  F  + +   +  P LL IL+ +I + +   W G+ LA        + +L  +  +    ++++R+R A+IG+IYRK L + N ++ + T GE+VNLMSVDA+R M+   F     S PLQ++LAI  L+Q +  +  AG+ +IV   PLNG +   M+ +   ++K+KD RIK+++EILNGIKVLK+YAWE SFL+++  +R +E++ + + +    +   +W   PFL+ L T   YV   E N++  EKAFVSL+LFN+L+ P+ +LP  ++    A VSLKRI  +L   EL+   +  +  +   A      I I +G+F+W ++   TL+++N +I +G LVA+VG VG GKSSL+SA+LGEM ++ G VSV+G++AYV Q+AWIQN +L+EN+LF Q  N K Y+  +E C+L +DL+ LPGGD+TEIGE+GINLSGGQ+QRVSLARAVY + +I+LLDDPLSAVD+HV +H+F+ VI   G+L  KTR+LVTHG+++LP+ D ++VL + G +SE G +  LL+    F  F++ Y    ++  + +  Q+ ++E  L             ED +   TD     PA+   R    R  ++                        S+ G  E ++   P+  T   +   +  +T         K    L++EE A +G VK + Y    KS GL   ++   +Y   +   + +N+WL  ++ D++ ++  Q+                 +T   + +Y  +G+   L+V     +  VG+I A++++H+ LL + +RSP  FFDTTPSGRI+NRFSKDI  +D ++   I   L+  F   ++I+VI+  TP F + ++PLA+LY  +Q FY+ TSRQ +RL+SI+ SP+F+HF+ET+ G ++IRA+   Q F+ L+ T +D + K  +   +S RWL + +E +G  +V  A LF++IGR SL   LVGLS+SY+LQ+T  LNW++R  ++LE+N +A+ER++EYSK  +EA W  + N AP + WP  G + F++Y +RYR GL LVLKN+ +H  GG+K+G+VGRTGAGKSS+ L LFR++EAA G I+ID +N++ IGLHDLR +LTI+PQDP++FSGTLR NLDPF  + +++I+++LE +HL ++VS    GLD++C EGG NLSV                      GQ+QL+CLARALLRKS+VL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D + ++V++ G + E DSP NL+A + GIF
Sbjct:  104 VFFVTPLVVGITMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTT-----FYIYFALVFCALILSCFKE--KPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHK---VVQRLLE-----AWQKQQNQASGSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGYA------ITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-AGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLL------------LEDTLSTHTDLTDNEPAIYEVRKQFMREMSSL-----------------------SSEG--EVQNRTMPKKHTNSLEKEALVTKT---------KETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAE-EHGQQN-----------------KTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAP-EGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSV----------------------GQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIF 1513

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BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|O88563|MRP3_RAT (Canalicular multispecific organic anion transporter 2 OS=Rattus norvegicus OX=10116 GN=Abcc3 PE=1 SV=1)

HSP 1 Score: 1004.59 bits (2596), Expect = 0.000e+0
Identity = 579/1527 (37.92%), Postives = 894/1527 (58.55%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNII------RLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKI---PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKL---TNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL--NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            ++ ++ +++ IT++LA L  +  R        +L IFWL   I  ++     I+      ++LD  P+             F L L  F+  CF    K  L  P  +   PCPE  A   S+L++ W        +R+ + D   + L  +D S K   +++++       +  +++       TA++   +  ED++     P  + P ++   +L R +   LL+   FK + D S  +            +     YW G+ LA        + +L  +  +    ++++RIR A+IG+IYRK L + N ++ ++T GE+VNLMSVDA+R M+   F     S PLQ++LAI  L+Q +  +  AG+ +IV   PLNG +   M+ +   ++K+KD RIK+++EILNGIKVLK+YAWE +FL+++  +R  E++ + + +    +   +W   PF++ L T   YV   + N++  EKAFVSL+LFN+L+ P+ +LP  ++      VSLKRI  +L  +EL+   +  +  +   A      I I +G+FSW K+   TL++IN +I +G LVA+VG VG GKSSL+SA+LGEM ++ G+VSV+G++AYV Q+AWIQN +L+EN+LF Q  N K Y+  +E C+L +DL+ LPGGD+TEIGE+GINLSGGQ+QRVSLARAVY + +I+LLDDPLSAVD+HV +H+F+ VI   G+L  KTR+LVTHG+++LP+ D ++VL ++G I+E G + +LL+    F  F++ Y    N+  N    QH ++E  L             ED +   TD   T PA+   R                            ++    +S   E E    P +       ++ +   ++       K    L++EE A +G VK + Y    KS GL   +    +YA    + + +N+WL  +T  +D++   Q                +  T   + +Y  +G+   L+V     +  VG+I A++++H  LL + +R+P  FFDTTPSGRI+NRFSKDI  +  ++   I    +  +   ++I+VI+  TP F + ++PLA+ Y  +Q FY+ TSRQ +RL+S++ SP+F+HF+ET+ G ++IRA+   Q F+ L+   +D + K  +   +S RWL + +E +G  +V  + LF++IGR SL   LVGLS+SY+LQ+T  LNW++R  ++LE+N +A+ER++EYSK  +EA W L  N AP + WP +G + F++Y +RYR GL LVLKN+ LH  GG+K+G+VGRTGAGKSS+ L LFR++EAA G I ID +N++ IGLHDLR +LTI+PQDP++FSGTLR NLDPF  + D++I+++LE +HL ++VS    GLD++C EGG NLSV                      GQ+QL+CLARALLRKS+VL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D + ++V++ G + E DSP NL+A + GIF  +
Sbjct:  104 VFFITPLLVGITMLLATLLIQYERLRGVRSSGVLIIFWLLCVICAIIPFRSKILLALAEGKILD--PFRFTT-----FYIYFALVLCAFILSCFQE--KPPLFSPENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHK---VVQRLLE-----AWQKQQTQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLR--ALVRTFTSSLLMGACFKLIQDLSPSSTHSCSASSSGLFRPHGP-YWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKALTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQGELQLLRKGAYLQAISTFIWVCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSLKRIQDFLNQDELDPQCVERKTISPGRA------ITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-ADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVLL------------LEDTLSTHTDLTDTEPAIYEVRK---------------------------QFMREMSSLSSEGEGQNRPVL-------KRYTSSLEKEVPATQTKETGALIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICLLYAGQNAVAIGANVWLSAWT--NDVEEHGQ----------------QNNTSVRLGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDIYVIHEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSALFAVIGRNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAP-EGWPRSGVVEFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSV----------------------GQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIFYGM 1515

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BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A210QB02 (Multidrug resistance-associated protein 1 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT07304 PE=4 SV=1)

HSP 1 Score: 1112.44 bits (2876), Expect = 0.000e+0
Identity = 647/1629 (39.72%), Postives = 968/1629 (59.42%), Query Frame = 3

Query:   75 EICQDGFWNSTSFSNVKYPIFTECFQYVILL-IPSGXXXXXXXXXXXXKKYKSHPIIKVPCTFYYGLKLSSQAXXXXXXXXXXXXXXXXTKSNSLIDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFY-----DKIKISHNRKR---YDLLQNSTASVAHLMED--EDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNY----WIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGR--FSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            E C   FW+     N  +P FTECFQ  +L+ +P G   +    +  +    +   +K  C++ + +KL+   +++  L   I+      K         ++  +I  ITL +  L   + R        +LF++W+      ++ LY  II+      Y        +      L L+  L HC +    + L   +K+  PE+ AS LS+++++WLD  +   +RK +T+E  F+L   + S       E+ +       KIK   +R         +NST     L     + K  +P        L   L + +GLELL A  FK  +D   +A PFLL+ L+++     D      W GY L   F    ++ S   +  F +++ L +R+RA +I  +Y+K L +++  R + T+GEIVNLMSVD ERI++ + + W   S PLQ+ +A+  LY  M  ++FAG G ++  FPLNG LM  +QK    ++K KD+RIK++ E+LNGIK+LK+YAWE SF +KI  +R  E++YI + +  FG   +  W I P+L+ LATF  ++  S+ + + P+ AFV+++LFN+LRF + + P  +T+ + A VS+KR+ ++L  E+L+   ++H     D       A+ IRDG F W +E   TL++IN  +  G LVA+VG+VG GKSSLISAILGEM ++ G V+V+G+++Y+ Q+AWIQN +L++NILF +   ++ Y++I+++C+L SD++ LP GD+TEIGE+GINLSGGQKQRVSLARAV+ N DIYLLDDPLSAVD+HVG+H+F+ VI   G+LKDKTR+L+THG+ WLP VD ++V+D NG ++E GS+ +LL     F +F+Q Y   N    +      +    A  KA+ L R  S N    EE  + +  S +     + + R   +                      +  + G+  D+  K   +    S+   + K+TD            +L+EEEQ+ +G+VK A +    +S GL   IA V + A F  + V SN+WL N+T D+ + N +          P  S I  ++ KYY+ IY  +G   ++ +  +       ++ ASKV+H ++L  +LRSPM FFDTTP GRI+NRFS+D++ +D  +PM +   L CLF+V  S+ VI Y TP+F + I+P+  LY+L+Q FYIP+SRQ +R++S   SP++NHF+ETL G ++IRA+  Q  F   ++  +D + K+ F   SS RWL  R+E LG L++ AA L ++I R    +T S+VGLS++Y+LQITE LNW++R  +ELET  V++ER++EY++IP E +    ++ P   WP NG + FK+Y  RYR GL LVLKNI++    G+K+G+VGRTGAGKSSL LALFRL+E A GSIIID  N++ +GLHD R RLTILPQDPVIFSG+LR NLDP   + D++++ +LE AHL+++   L+ GL+Y+CGEGG NLSV                      GQ+QL+CLAR+LLRK+K+L+LDEATA+VD+ETD L+  TIR  F+ STV+ IAHR+NTI+D D I+V++ GEI E DSP +LL  +  +F  L
Sbjct:    3 EYCNGTFWDINETWNSSWPQFTECFQNTVLVWVPCGFVWLALPFYLWYLLSVAGTTLK--CSWKHRIKLAIVVILMAFLAYWIVEVVNDLKPEEQYWRAKLVGPIIYLITLCVVFLLMCLERWKALVTSGVLFVYWVLVAFTLIIPLYSMIIQ----KAYKDHLNGFVIFMVSTGLVLIQVLVHCVA----EELPHTDKLISPEIKASFLSRMSFTWLDGLMVTGYRKTLTEEDVFNLGPSELSQNVVPRFERNWQRESAKQKIKAQTSRITEIPASSFENSTERTPLLASSPPDSKKDSPKKLVGKPSLTKVLFKTFGLELLNAHIFKLFYDALNFANPFLLRFLIDFTVPGPDGVYQQSWRGYVLTAGFFLTTIMQSFLFHQVFHMSTTLGLRVRAVIISAVYKKALSMSSASRKESTTGEIVNLMSVDTERIVSTLQYLWGIWSSPLQMAVALYFLYGTMGPSMFAGFGSLILMFPLNGYLMYKLQKLQEQQMKQKDIRIKVINEVLNGIKILKLYAWEMSFKEKIAAVRKLELKYIWK-AGIFGCGFMFSWYIAPYLVSLATFATFIFASDNHFLDPQTAFVAISLFNILRFAVNIAPAVITEVVTANVSMKRLSKFLNSEDLDAKCVSHSSLERD-------AVVIRDGEFLWDEEVGTTLSDINVRVPEGGLVAVVGQVGAGKSSLISAILGEMTKVKGQVNVKGSLSYIPQQAWIQNATLQDNILFGEKLQQQRYDEILDSCALVSDMDMLPAGDQTEIGEKGINLSGGQKQRVSLARAVHFNSDIYLLDDPLSAVDSHVGKHIFDRVIGRKGLLKDKTRVLITHGVQWLPHVDTIVVMD-NGRVTEIGSYDELLSHAGAFAKFLQTYFVQNEEDSDEEEDPEI----AATKARILQRLTSINS---EEGGELLRASESESGTDDKTLRRRKS----------------------KGLDRGMSRDDGEKKKGLDRALSKEAAVEKKTDD-----------KLIEEEQSETGSVKLAVFFAYARSLGLPYAIALVLLSAGFQAMGVLSNMWLSNWTGDATLNNRTL--------GPPDSSIYMDKNKYYLGIYGALGAGQSIFITVFSLVLVFRTVKASKVLHGQMLHGILRSPMSFFDTTPIGRIVNRFSQDMDIIDRELPMTVQMFLDCLFMVIGSLFVISYSTPFFMVIILPVGFLYFLVQRFYIPSSRQLKRVESKTRSPIYNHFSETLAGASVIRAYSVQHKFITQSEERVDLNQKYSFASFSSNRWLGFRLEFLGNLIIVAAALLTVISRDGSGITGSIVGLSVTYALQITENLNWMVRMSSELETKVVSVERVKEYAEIPHEDKLVYKSHRPPSLWPENGEVKFKNYSTRYRTGLDLVLKNIDVTIQPGEKVGIVGRTGAGKSSLTLALFRLIEPASGSIIIDGENLNRMGLHDSRSRLTILPQDPVIFSGSLRMNLDPLDEYMDNDLWDALEHAHLKTFAQSLATGLEYDCGEGGQNLSV----------------------GQRQLVCLARSLLRKTKILVLDEATAAVDMETDDLIQQTIRTEFKDSTVLTIAHRLNTIMDYDRIMVLDKGEICEFDSPNSLLKNTSSVFYQL 1542

HSP 2 Score: 111.309 bits (277), Expect = 1.660e-20
Identity = 125/523 (23.90%), Postives = 227/523 (43.40%), Query Frame = 3

Query: 1146 FFGVLSSLAENGCFFITSI------LSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWI-IFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYL-VGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNE-FMQFVQE 2648
            + G+  +L      FIT         +++    L G +    LR      +    G IVN  S D + I   + +    FL C   ++ ++ ++     + +   L +   +F +    +   ++   +E K +       +E L G  V++ Y+ +  F+ +     D   +Y     ++   +    E L  LI++A  L  V++ + + IT     +S+T    +   +  +    ++     VS++R+ +Y  +  E  L   +HR     S +  +  ++ ++ S  ++    L L NI+  I  G+ V IVG+ G GKSSL  A+   +   +GS+ + G              +  + Q+  I + SL+ N+    +Y +    D +E   LK+  + L  G E + GE G NLS GQ+Q V LAR++ +   I +LD+  +AVD      L +  I      KD T + + H LN +   D ++VLD  G I E  S   LLK+ +  F Q  ++
Sbjct: 1030 YLGIYGALGAGQSIFITVFSLVLVFRTVKASKVLHGQMLHGILRSPMSFFDTTPIGRIVNRFSQDMDIIDRELPMTVQMFLDCLFMVIGSLFVISYSTPFFMVIILPVGFLYFLVQRFYIPSSRQLKRVESKTRSPIYNHFSETLAGASVIRAYSVQHKFITQSEERVDLNQKYSFASFSSNRWLGFRLEFLGNLIIVAAALLTVISRDGSGITGSIVGLSVTYALQITENLNWMVRMSSELETKVVSVERVKEYAEIPHEDKLVYKSHRP---PSLWPENGEVKFKNYSTRYRTGLDLVLKNIDVTIQPGEKVGIVGRTGAGKSSLTLALFRLIEPASGSIIIDGENLNRMGLHDSRSRLTILPQDPVIFSGSLRMNLDPLDEYMDNDLWDALEHAHLKTFAQSLATGLEYDCGEGGQNLSVGQRQLVCLARSLLRKTKILVLDEATAAVDMET-DDLIQQTIRTE--FKDSTVLTIAHRLNTIMDYDRIMVLD-KGEICEFDSPNSLLKNTSSVFYQLAKD 1545

HSP 3 Score: 87.4261 bits (215), Expect = 3.047e-13
Identity = 80/308 (25.97%), Postives = 136/308 (44.16%), Query Frame = 3

Query: 4020 TELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENL---DPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNN 4925
            TE+ T  V+++R+   SK  +  + D       S   +  +  +D +  + E +   L +IN+    G  + VVG+ GAGKSSL  A+   +    G +             +++  L+ +PQ   I + TL++N+   +     + DEI   L++  L S +  L  G   E GE G+NLS                       GQKQ + LARA+   S + +LD+  ++VD    + +   +   +   +  T ++I H +  +   D IVVM+NG + EI S   LL+ +    K L    + N
Sbjct:  597 TEVVTANVSMKRL---SKFLNSEDLDAKCVSHSSLERDA-VVIRDGEFLWDEEVGTTLSDINVRVPEGGLVAVVGQVGAGKSSLISAILGEMTKVKGQV-------------NVKGSLSYIPQQAWIQNATLQDNILFGEKLQQQRYDEI---LDSCALVSDMDMLPAGDQTEIGEKGINLS----------------------GGQKQRVSLARAVHFNSDIYLLDDPLSAVDSHVGKHIFDRVIGRKGLLKDKTRVLITHGVQWLPHVDTIVVMDNGRVTEIGSYDELLSHAGAFAKFLQTYFVQN 862

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BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A1I8HN92 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 1085.86 bits (2807), Expect = 0.000e+0
Identity = 618/1467 (42.13%), Postives = 910/1467 (62.03%), Query Frame = 3

Query:  681 EVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNIL-EKIFY------------------DKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGW-----VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED-KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLS----------------DESALGKAKNLLRQL----SDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDE----DPKSPRIMTPGSQSRQISKETDQNTDRLID------KPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            E  +SI+S+LT+SWLD  +   +RKE+ +    D+ R D S +   +  E + Y                  + +  +H+R   D  Q   + V+    + D+L + D+R          L  +L + +G +L+L+ +   +H    +A PFLL+ L+ +  N  +  W G      F    VLSS+  +  F ++    I+ R+ALI  IYRK+L L  E R + T GEIVNLM+VD+ +I + I F W  L  P+QIV+A+++L+ ++  A+ AG+G+ V   P+NG +M   QK    E+K KD R+K+L E+LN +KV+K+YAWE SF  KI+++R TE+ ++ ++S  F VV ++W + PFL+M+ TF+ Y+ + + +I+T  KAFVSLTLFN+LRFP+ VLPW +T+S+NA+VS+KRI  +L  ++++ + +     + D       ++EI   SF WK+ D +  L ++N ++ +GKL+AIVGKVG GKSSL+ ++LGE  +  GS++ +G++AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  F++E+  H+   K  S  + +S                DE    +   +L++L    S   +V  E    V TSP+   Q    H                      HV+   +S +    D     D K P I+   S+  Q++ E   + D  +D      +   +L++EE   SG+V   +Y   I +RG  L + T+  + A+T + V S++WL  +T D    NAS  +  N++ S Y    +R+   YY+ IY I G+ + ++V  Y       ++ AS+ IHK LL  + R PM FFDTTP+GRI+NRFSKD+E +D  +PM I+D L C     + I+VI Y TP F  A++PL I+Y  IQ+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F  ++   +D +S+F F++ +S RWL  R+E+LG   V  A L +++GR SLT  LVGLS+SY+LQI++ LNW++RQ TELETN VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+A G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW  GLS GL +ECGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G + E   P++LLA  D  F  L  ++
Sbjct: 1980 ECRSSIISRLTFSWLDRSVLNAYRKEIGEA---DVNRLDPSLRVRTVHGEFVRYFPPLVALSRSERDAAEQQENLSFTHHRVNADTEQLVDSGVS----EGDQLHSNDSRDGAGGRHRRKLLPALWKAFGSQLILSWSIMMIHGLLAFANPFLLESLINFSTN-GEELWHGILYTFLFFVVAVLSSITFHASFQLSLTCGIKFRSALIASIYRKSLTLTQESRARSTVGEIVNLMTVDSNKIADSIPFFWAMLVSPVQIVIALVMLWAQLGTAVLAGIGIFVVIIPVNGYIMAKAQKLEEKEMKTKDERLKLLNEVLNAMKVIKLYAWEPSFQQKISHVRRTEVGFLGQMSYLFSVVIIMWTVAPFLVMVLTFITYIYSGDDHILTASKAFVSLTLFNILRFPITVLPWTITESVNAYVSIKRIQNFLFEDDIDESSVLKLPSSPDGN-----SVEIEGASFGWKRTDSEPLLKDVNIQVPKGKLIAIVGKVGCGKSSLLQSVLGETVKFCGSITTRGSVAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFASFLKEFFLHDGERKRASRSRDVSVSIAEIAAAAPEEEEEDEELAAEKARILQRLASCTSSAHEVCAESPAVVATSPS---QSPPPH----------------------HVRQMSSSVNSHCSDTADRLDSKRPSIVRQTSKISQLTSEKLPSRDEDVDGTRKAAEQSGRLIDEETMESGSVSLKSYVFYIAARGYHLVLMTIMAHLAYTVVNVASSVWLSTWTSDPLFSNAS--VTGNLNNSAY----LRDINDYYLSIYGIFGVGIVVLVGIYAVMGVYSALRASRSIHKSLLTRLFRVPMSFFDTTPTGRIVNRFSKDMEVVDRELPMIINDFLECFMATVSCIVVISYTTPIFLAAVVPLGIIYAGIQVFYLPISRQSRRLDSRSRSPILTNFSESIAGAAVIRAFRQQQRFVGISDYRVDNNSRFYFLKLASNRWLGFRLELLGTAAVVIAALLAVLGRDSLTPGLVGLSVSYALQISDALNWMVRQLTELETNSVAVERLDEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRPGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESAFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRVREFAPPRDLLAKQDSYFHFLAKEA 3379

HSP 2 Score: 1061.21 bits (2743), Expect = 0.000e+0
Identity = 595/1435 (41.46%), Postives = 901/1435 (62.79%), Query Frame = 3

Query:  681 EVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNI-------------LEKIFYD------KIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGW-----VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED-KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNR----AKNPSGGQHLSDESA---------------LGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQ---SRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEI 4844
            E  +SI+S+LT+SWLD  +   +RKE+ +    D+ R D S +   +             L +   D       +  +H+R   D  Q   + V+    + D+L + D+R          L  +L + +G +L+L+ A   +H    +A P LL+ L+++    S+  W G+F    F    +LSSLA +    I+ +  I+IR+ALI  IYRK+L L  E R++ T GEIVNL++VD+ +I + + F W  L  P+QI LA+++L+ ++  A+ AG+ + +   PLN ++M   Q     E+K KD R+++L E++N +KV+K+YAWE SF  KI  +R  E+  + + +    +V V W + PFL+M+ TF+ Y+ +   +++T  KAFVSLTLFN+L FP+ VLPW +T+S+NA+VSLKRI ++L  ++++ + +        S+ N+ AAIE+ +GSF+WK+ D +  L NIN  + RG LVA+VGKVG GKSSL+ ++LGE  R+ GSV++ G+ AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  F++E+  H+      +++P+G   LS++ +                 + + +LR+L+ +     +  +F   +P+V  + +     S+       S             Y  +++    E  D K P  +   S+   + ++ K  +   +R + +   +L++EE   +G V   +Y     +RGL   I    ++A F+ ++V S+IWL  +T D    N++      I G+   S ++RE   YY+ IY  +G+ + L+V  +     V S+ AS++IH  LL S+ R+PM FFDTTP+GRI+NRFSKD+E +DH +PM I+D   CL    + I+VI Y TP F  A++PL I+Y ++Q+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F +++   +D +++F F++ +S RWL  R+E+LG + V  A L +++ R SLT  LVGLS+SY+L I+  LNW++RQ TELET+ VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR+GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+  G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW  GLS GL +ECGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G +
Sbjct:  373 ECRSSIISRLTFSWLDRSVLNAYRKEIGEA---DVNRLDPSLRVRTVHGEFVRYFPPLVALSRSVRDAAEQQENLSFTHHRVNADTEQLVDSGVS----EGDQLHSNDSRDGAGGRHRRKLLPALWKAFGGQLMLSWAVVMIHGLLEFANPLLLEQLIKF-SGSSEELWHGFFYTFLFFSVALLSSLAFHNSCQISLMSGIKIRSALIAAIYRKSLSLTLEARSRSTVGEIVNLLTVDSNKIADAVPFLWVVLVSPVQIFLALVMLWMQLGIAVLAGIAVFLVIIPLNAVVMVKSQSLEEREMKTKDERMRLLNEVINAMKVIKLYAWEPSFWQKIDQVRKKEVGLLAKNAYLLVLVVVSWTVAPFLVMVVTFITYIYSGNDHVLTASKAFVSLTLFNILHFPIAVLPWTITESVNAYVSLKRIQRFLDEDDIDDSSV----LKLPSSENHGAAIEVVNGSFAWKRSDTEALLQNINLTVPRGSLVAVVGKVGCGKSSLLQSVLGETVRLCGSVAMTGSAAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFASFLKEFFLHDGERKRASRSPAGSISLSNKPSSDFPAEDIDEEDEEVRAEKERILRRLASHSG--HQACEF---NPSVQAETHIPQLSSSPVAHGLPSSIG---------SYCSDAS----ERVDAKRPPALRQTSRVLDAHEVPKLHESRHERTVTEDDGKLIDEETMETGRVSLKSYVYYASARGLHYVIIMSLLHAGFSAVEVASSIWLSTWTSDPMFNNST------IYGNLNNSVLLRELNDYYIEIYGTLGVAVVLLVAIFAMIEAVSSLRASRLIHNSLLSSLFRAPMSFFDTTPTGRIVNRFSKDMEVVDHELPMVINDFYECLMASLSCIVVISYTTPIFLAAVLPLGIIYAIVQVFYLPISRQSRRLDSRSRSPILTNFSESVAGAAIIRAFRQQQRFIHISDDRVDCNARFYFLKVASNRWLGFRLELLGTVAVTIASLLAVLARGSLTPGLVGLSVSYALDISNSLNWMVRQLTELETDSVAVERLNEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRQGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESTFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRV 1748

HSP 3 Score: 78.5666 bits (192), Expect = 1.649e-10
Identity = 66/214 (30.84%), Postives = 101/214 (47.20%), Query Frame = 3

Query: 1998 WKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSL-------ISAILGEMH----RIN--GSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDI---IEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISER 2591
            +++   L L  I+     G  V IVG+ G GKSSL       I +  G +     RI+  G  S++  +  + QE  + + SL+ N+     ++E+  E++   ++A  L S    L  G   E GE G NLS GQ+Q V LARA+ +   + +LD+  +AVD      +   V        D T I++ H L  +   D V+VLDS    S R
Sbjct: 1545 YRQGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESTFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNL---DPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSVGQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQ---FADSTVIIIAHRLATIMDSDRVMVLDSGRVESSR 1752

HSP 4 Score: 76.6406 bits (187), Expect = 7.236e-10
Identity = 78/272 (28.68%), Postives = 119/272 (43.75%), Query Frame = 3

Query: 4131 NGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENL---DPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKS------LHD 4910
            NG+  +K  D         +L+NINL    G  + VVG+ G GKSSL  ++        GS+              +      +PQ+  I + T+R+N+     F   + DE   +L    L+  +  L+ G   E GE G+NLS                       GQKQ + LARA+ + S + +LD+  A+VD    + + H +       +  T I++ H I+ +   D IVV++NG I E  S ++LL   DG F S      LHD
Sbjct:  819 NGSFAWKRSDTEA------LLQNINLTVPRGSLVAVVGKVGCGKSSLLQSVLGETVRLCGSVA-------------MTGSAAYVPQEAWIQNLTVRDNILFGRDFDQARYDE---ALRACQLEKDLQLLTAGDATEIGERGINLS----------------------GGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVIDNGRISEQGSYEHLLD-HDGPFASFLKEFFLHD 1045

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A1I8GTT5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 1083.17 bits (2800), Expect = 0.000e+0
Identity = 618/1467 (42.13%), Postives = 910/1467 (62.03%), Query Frame = 3

Query:  681 EVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNIL-EKIFY------------------DKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGW-----VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED-KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLS----------------DESALGKAKNLLRQL----SDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDE----DPKSPRIMTPGSQSRQISKETDQNTDRLID------KPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            E  +SI+S+LT+SWLD  +   +RKE+ +    D+ R D S +   +  E + Y                  + +  +H+R   D  Q   + V+    + D+L + D+R          L  +L + +G +L+L+ +   +H    +A PFLL+ L+ +  N  +  W G      F    VLSS+  +  F ++    I+ R+ALI  IYRK+L L  E R + T GEIVNLM+VD+ +I + I F W  L  P+QIV+A+++L+ ++  A+ AG+G+ V   P+NG +M   QK    E+K KD R+K+L E+LN +KV+K+YAWE SF  KI+++R TE+ ++ ++S  F VV ++W + PFL+M+ TF+ Y+ + + +I+T  KAFVSLTLFN+LRFP+ VLPW +T+S+NA+VS+KRI  +L  ++++ + +     + D       ++EI   SF WK+ D +  L ++N ++ +GKL+AIVGKVG GKSSL+ ++LGE  +  GS++ +G++AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  F++E+  H+   K  S  + +S                DE    +   +L++L    S   +V  E    V TSP+   Q    H                      HV+   +S +    D     D K P I+   S+  Q++ E   + D  +D      +   +L++EE   SG+V   +Y   I +RG  L + T+  + A+T + V S++WL  +T D    NAS  +  N++ S Y    +R+   YY+ IY I G+ + ++V  Y       ++ AS+ IHK LL  + R PM FFDTTP+GRI+NRFSKD+E +D  +PM I+D L C     + I+VI Y TP F  A++PL I+Y  IQ+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F  ++   +D +S+F F++ +S RWL  R+E+LG   V  A L +++GR SLT  LVGLS+SY+LQI++ LNW++RQ TELETN VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+A G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW  GLS GL +ECGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G + E   P++LLA  D  F  L  ++
Sbjct: 1130 ECRSSIISRLTFSWLDRSVLNAYRKEIGEA---DVNRLDPSLRVRTVHGEFVRYFPPLVALSRSERDAAEQQENLSFTHHRVNADTEQLVDSGVS----EGDQLHSNDSRDGAGGRHRRKLLPALWKAFGSQLILSWSIMMIHGLLAFANPFLLESLINFSTN-GEELWHGILYTFLFFVVAVLSSITFHASFQLSLTCGIKFRSALIASIYRKSLTLTQESRARSTVGEIVNLMTVDSNKIADSIPFFWAMLVSPVQIVIALVMLWAQLGTAVLAGIGIFVVIIPVNGYIMAKAQKLEEKEMKTKDERLKLLNEVLNAMKVIKLYAWEPSFQQKISHVRRTEVGFLGQMSYLFSVVIIMWTVAPFLVMVLTFITYIYSGDDHILTASKAFVSLTLFNILRFPITVLPWTITESVNAYVSIKRIQNFLFEDDIDESSVLKLPSSPDGN-----SVEIEGASFGWKRTDSEPLLKDVNIQVPKGKLIAIVGKVGCGKSSLLQSVLGETVKFCGSITTRGSVAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFASFLKEFFLHDGERKRASRSRDVSVSIAEIAAAAPEEEEEDEELAAEKARILQRLASCTSSAHEVCAESPAVVATSPS---QSPPPH----------------------HVRQMSSSVNSHCSDTADRLDSKRPSIVRQTSKISQLTSEKLPSRDEDVDGTRKAAEQSGRLIDEETMESGSVSLKSYVFYIAARGYHLVLMTIMAHLAYTVVNVASSVWLSTWTSDPLFSNAS--VTGNLNNSAY----LRDINDYYLSIYGIFGVGIVVLVGIYAVMGVYSALRASRSIHKSLLTRLFRVPMSFFDTTPTGRIVNRFSKDMEVVDRELPMIINDFLECFMATVSCIVVISYTTPIFLAAVVPLGIIYAGIQVFYLPISRQSRRLDSRSRSPILTNFSESIAGAAVIRAFRQQQRFVGISDYRVDNNSRFYFLKLASNRWLGFRLELLGTAAVVIAALLAVLGRDSLTPGLVGLSVSYALQISDALNWMVRQLTELETNSVAVERLDEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRPGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESAFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRVREFAPPRDLLAKQDSYFHFLAKEA 2529

HSP 2 Score: 718.768 bits (1854), Expect = 0.000e+0
Identity = 406/939 (43.24%), Postives = 596/939 (63.47%), Query Frame = 3

Query: 2157 GTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFM-QFVQEYIEHNNRAKNPSGGQHLSDESA---------------LGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQ---SRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            G+ AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  +F     E    +++P+G   LS++ +                 + + +LR+L+ +     +  +F   +P+V  + +     S+       S             Y  +++  V    D K P  +   S+   + ++ K  +   +R + +   +L++EE   +G V   +Y     +RGL   I    ++A F+ ++V S+IWL  +T D    N++      I G+   S ++RE   YY+ IY  +G+ + L+V  +     V S+ AS++IH  LL S+ R+PM FFDTTP+GRI+NRFSKD+E +DH +PM I+D   CL    + I+VI Y TP F  A++PL I+Y ++Q+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F +++   +D +++F F++ +S RWL  R+E+LG + V  A L +++ R SLT  LVGLS+SY+L I+  LNW++RQ TELET+ VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR+GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+  G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW           CGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G + E   P++LLA  D  F  L  ++
Sbjct:    1 GSAAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFAREFFLHDGERKRASRSPAGSISLSNKPSSDFPAEDIDEEDEEVRAEKERILRRLASHSG--HQACEF---NPSVQAETHIPQLSSSPVAHGLPSSIG---------SYCSDASERV----DAKRPPALRQTSRVLDAHEVPKLHESRHERTVTEDDGKLIDEETMETGRVSLKSYVYYASARGLHYVIIMSLLHAGFSAVEVASSIWLSTWTSDPMFNNST------IYGNLNNSVLLRELNDYYIEIYGTLGVAVVLLVAIFAMIEAVSSLRASRLIHNSLLSSLFRAPMSFFDTTPTGRIVNRFSKDMEVVDHELPMVINDFYECLMASLSCIVVISYTTPIFLAAVLPLGIIYAIVQVFYLPISRQSRRLDSRSRSPILTNFSESVAGAAIIRAFRQQQRFIHISDDRVDCNARFYFLKVASNRWLGFRLELLGTVAVTIASLLAVLARGSLTPGLVGLSVSYALDISNSLNWMVRQLTELETDSVAVERLNEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRQGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESTFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARA-------SCGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRVREFAPPRDLLAKQDSYFHFLAKEA 885

HSP 3 Score: 79.7221 bits (195), Expect = 8.414e-11
Identity = 67/230 (29.13%), Postives = 106/230 (46.09%), Query Frame = 3

Query: 1998 WKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSL-------ISAILGEMH----RIN--GSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            +++   L L  I+     G  V IVG+ G GKSSL       I +  G +     RI+  G  S++  +  + QE  + + SL+ N+     ++E+  E++  A     D   L        GE G NLS GQ+Q V LARA+ +   + +LD+  +AVD      +   V        D T I++ H L  +   D V+VLDS G + E    +DLL   + +  F+ +
Sbjct:  665 YRQGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESTFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNL---DPFDERTDEELWAAL----DAAHLSSWARASCGEGGTNLSVGQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQ---FADSTVIIIAHRLATIMDSDRVMVLDS-GRVREFAPPRDLLAKQDSYFHFLAK 883

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A1I8JGC8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 1082.01 bits (2797), Expect = 0.000e+0
Identity = 615/1467 (41.92%), Postives = 907/1467 (61.83%), Query Frame = 3

Query:  681 EVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNIL-EKIFY------------------DKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGW-----VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED-KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLS----------------DESALGKAKNLLRQL----SDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDE----DPKSPRIMTPGSQSRQISKETDQNTDRLID------KPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            E  +SI+S+LT+SWLD  +   +RKE+ +    D+ R D S +   +  E + Y                  + +  +H+R   D  Q   + V+    + D+L + D+R          L  +L + +G +L+L+ +   +H    +A PFLL+ L+ +  N  +  W G      F    VLSS+  +  F ++    I+ R+ALI  IYRK+L L  E R + T GEIVNLM+VD+ +I + I F W  L  P+QIV+A+++L+ ++  A+ AG+G+ V   P+NG +M   QK    E+K KD R+K+L E+LN +KV+K+YAWE SF  KI+++R TE+ ++ ++S  F VV ++W + PFL+M+ TF+ Y+ + + +I+T  KAFVSLTLFN+LRFP+ VLPW +T+S+NA+VS+KRI  +L  ++++ + +     + D       ++EI   SF WK+ D +  L ++N ++ +GKL+AIVGKVG GKSSL+ ++LGE  +  GS++ +G++AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  F++E+  H+   K  S  + +S                DE    +   +L++L    S   +V  E    V TSP+   Q    H                      HV+   +S +    D     D K P I+   S+  Q++ E   + D  +D      +   +L++EE   SG+V   +Y   I +RG  L + T+  + A+T + V S++WL  +T D    NAS  +  N++ S Y    +R+   YY+ IY I G+ + ++V  Y       ++ AS+ IHK LL  + R PM FFDTTP+GRI+NRFSKD+E +D  +PM I+D L C     + I+VI Y TP F  A++P A+     Q+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F  ++   +D +S+F F++ +S RWL  R+E+LG   V  A L +++GR SLT  LVGLS+SY+LQI++ LNW++RQ TELETN VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+A G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW  GLS GL +ECGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G + E   P++LLA  D  F  L  ++
Sbjct: 1729 ECRSSIISRLTFSWLDRSVLNAYRKEIGEA---DVNRLDPSLRVRTVHGEFVRYFPPLVALSRSERDAAEQQENLSFTHHRVNADTEQLVDSGVS----EGDQLHSNDSRDGAGGRHRRKLLPALWKAFGSQLILSWSIMMIHGLLAFANPFLLESLINFSTN-GEELWHGILYTFLFFVVAVLSSITFHASFQLSLTCGIKFRSALIASIYRKSLTLTQESRARSTVGEIVNLMTVDSNKIADSIPFFWAMLVSPVQIVIALVMLWAQLGTAVLAGIGIFVVIIPVNGYIMAKAQKLEEKEMKTKDERLKLLNEVLNAMKVIKLYAWEPSFQQKISHVRRTEVGFLGQMSYLFSVVIIMWTVAPFLVMVLTFITYIYSGDDHILTASKAFVSLTLFNILRFPITVLPWTITESVNAYVSIKRIQNFLFEDDIDESSVLKLPSSPDGN-----SVEIEGASFGWKRTDSEPLLKDVNIQVPKGKLIAIVGKVGCGKSSLLQSVLGETVKFCGSITTRGSVAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFASFLKEFFLHDGERKRASRSRDVSVSIAEIAAAAPEEEEEDEELAAEKARILQRLASCTSSAHEVCAESPAVVATSPS---QSPPPH----------------------HVRQMSSSVNSHCSDTADRLDSKRPSIVRQTSKISQLTSEKLPSRDEDVDGTRKAAEQSGRLIDEETMESGSVSLKSYVFYIAARGYHLVLMTIMAHLAYTVVNVASSVWLSTWTSDPLFSNAS--VTGNLNNSAY----LRDINDYYLSIYGIFGVGIVVLVGIYAVMGVYSALRASRSIHKSLLTRLFRVPMSFFDTTPTGRIVNRFSKDMEVVDRELPMIINDFLECFMATVSCIVVISYTTPIFLAAVVPSALST---QVFYLPISRQSRRLDSRSRSPILTNFSESIAGAAVIRAFRQQQRFVGISDYRVDNNSRFYFLKLASNRWLGFRLELLGTAAVVIAALLAVLGRDSLTPGLVGLSVSYALQISDALNWMVRQLTELETNSVAVERLDEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRPGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESAFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRVREFAPPRDLLAKQDSYFHFLAKEA 3125

HSP 2 Score: 1074.31 bits (2777), Expect = 0.000e+0
Identity = 604/1459 (41.40%), Postives = 912/1459 (62.51%), Query Frame = 3

Query:  681 EVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNI-------------LEKIFYD------KIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGW-----VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED-KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAK----NPSGGQHLSDESA---------------LGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQ---SRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            E  +SI+S+LT+SWLD  +   +RKE+ +    D+ R D S +   +             L +   D       +  +H+R   D  Q   + V+    + D+L + D+R          L  +L + +G +L+L+ A   +H    +A P LL+ L+++    S+  W G+F    F    +LSSLA +    I+ +  I+IR+ALI  IYRK+L L  E R++ T GEIVNL++VD+ +I + + F W  L  P+QI LA+++L+ ++  A+ AG+ + +   PLN ++M   Q     E+K KD R+++L E++N +KV+K+YAWE SF  KI  +R  E+  + + +    +V V W + PFL+M+ TF+ Y+ +   +++T  KAFVSLTLFN+L FP+ VLPW +T+S+NA+VSLKRI ++L  ++++ + +        S+ N+ AAIE+ +GSF+WK+ D +  L NIN  + RG LVA+VGKVG GKSSL+ ++LGE  R+ GSV++ G+ AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  F++E+  H+   K    +P+G   LS++ +                 + + +LR+L+ +     +  +F   +P+V  + +     S+       S             Y  +++  V    D K P  +   S+   + ++ K  +   +R + +   +L++EE   +G V   +Y     +RGL   I    ++A F+ ++V S+IWL  +T D    N++      I G+   S ++RE   YY+ IY  +G+ + L+V  +     V S+ AS++IH  LL S+ R+PM FFDTTP+GRI+NRFSKD+E +DH +PM I+D   CL    + I+VI Y TP F  A++PL I+Y ++Q+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F +++   +D +++F F++ +S RWL  R+E+LG + V  A L +++ R SLT  LVGLS+SY+L I+  LNW++RQ TELET+ VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR+GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+  G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW  GLS GL +ECGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G + E   P++LLA  D  F  L  ++
Sbjct:  112 ECRSSIISRLTFSWLDRSVLNAYRKEIGEA---DVNRLDPSLRVRTVHGEFVRYFPPLVALSRSVRDAAEQQENLSFTHHRVNADTEQLVDSGVS----EGDQLHSNDSRDGAGGRHRRKLLPALWKAFGGQLMLSWAVVMIHGLLEFANPLLLEQLIKF-SGSSEELWHGFFYTFLFFSVALLSSLAFHNSCQISLMSGIKIRSALIAAIYRKSLSLTLEARSRSTVGEIVNLLTVDSNKIADAVPFLWVVLVSPVQIFLALVMLWMQLGIAVLAGIAVFLVIIPLNAVVMVKSQSLEEREMKTKDERMRLLNEVINAMKVIKLYAWEPSFWQKIDQVRKKEVGLLAKNAYLLVLVVVSWTVAPFLVMVVTFITYIYSGNDHVLTASKAFVSLTLFNILHFPIAVLPWTITESVNAYVSLKRIQRFLDEDDIDDSSV----LKLPSSENHGAAIEVVNGSFAWKRSDTEALLQNINLTVPRGSLVAVVGKVGCGKSSLLQSVLGETVRLCGSVAMTGSAAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFASFLKEFFLHDGERKRASRSPAGSISLSNKPSSDFPAEDIDEEDEEVRAEKERILRRLASHSG--HQACEF---NPSVQAETHIPQLSSSPVAHGLPSSIG---------SYCSDASERV----DAKRPPALRQTSRVLDAHEVPKLHESRHERTVTEDDGKLIDEETMETGRVSLKSYVYYASARGLHYVIIMSLLHAGFSAVEVASSIWLSTWTSDPMFNNST------IYGNLNNSVLLRELNDYYIEIYGTLGVAVVLLVAIFAMIEAVSSLRASRLIHNSLLSSLFRAPMSFFDTTPTGRIVNRFSKDMEVVDHELPMVINDFYECLMASLSCIVVISYTTPIFLAAVLPLGIIYAIVQVFYLPISRQSRRLDSRSRSPILTNFSESVAGAAIIRAFRQQQRFIHISDDRVDCNARFYFLKVASNRWLGFRLELLGTVAVTIASLLAVLARGSLTPGLVGLSVSYALDISNSLNWMVRQLTELETDSVAVERLNEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRQGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESTFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRVREFAPPRDLLAKQDSYFHFLAKEA 1511

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BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A267EF93 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017813g1 PE=4 SV=1)

HSP 1 Score: 1078.54 bits (2788), Expect = 0.000e+0
Identity = 613/1463 (41.90%), Postives = 907/1463 (62.00%), Query Frame = 3

Query:  681 EVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNI---LEKIFYDKIKISHNRKRYDLLQNSTASVAHLM------------EDEDKLTNPDNRSPGW-----VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED-KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLS----------------DESALGKAKNLLRQL----SDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDE----DPKSPRIMTPGSQSRQISKETDQNTDRLID------KPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            E  +SI+S+LT+SWLD  +   +RKE+ +    D+ R D S +   +     + F   + +S + +     Q + +   H +             + D+L + D+R          L  +L + +G +L+L+ +   +H    +A PFLL+ L+ +  N  +  W G      F    VLSS+  +  F ++    I+ R+ALI  IYRK+L L  E R + T GEIVNLM+VD+ +I + I F W  L  P+QIV+A+++L+ ++  A+ AG+G+ V   P+NG +M   QK    E+K KD R+K+L E+LN +KV+K+YAWE SF  KI+++R TE+ ++ ++S  F VV ++W + PFL+M+ TF+ Y+ + + +I+T  KAFVSLTLFN+LRFP+ VLPW +T+S+NA+VS+KRI  +L  ++++ + +     + D       ++EI   SF WK+ D +  L ++N ++ +GKL+AIVGKVG GKSSL+ ++LGE  +  GS++ +G++AYV QEAWIQN ++++NILF +D+++  Y++ + AC L+ DL+ L  GD TEIGERGINLSGGQKQRVSLARAVYQ+ DIYLLDDPL+AVD+HVG+ LF  VI  +G+L+DKTRILVTHG++WLP VDE++V+D NG ISE+GS++ LL     F  F++E+  H+   K  S  + +S                DE    +   +L++L    S   +V  E    V TSP+   Q    H                      HV+   +S +    D     D K P I+   S+  Q++ E   + D  +D      +   +L++EE   SG+V   +Y   I +RG  L + T+  + A+T + V S++WL  +T D    NAS  +  N++ S Y    +R+   YY+ IY I G+ + ++V  Y       ++ AS+ IHK LL  + R PM FFDTTP+GRI+NRFSKD+E +D  +PM I+D L C     + I+VI Y TP F  A++PL I+Y  IQ+FY+P SRQSRRLDS + SP+  +F+E++ G A+IRAF++QQ F  ++   +D +S+F F++ +S RWL  R+E++G   V  A L +++GR SLT  LVGLS+SY+LQI++ LNW++RQ TELETN VA+ER+ EYS + +EA W  ++ P   WP+ G + F +Y  RYR GL LVL+ I++ F  G K+G+VGRTGAGKSSL L LFRL+E+  G I +D + I  +GLH LR  LTILPQ+P +FSG+LR NLDPF    D+E++ +L+ AHL SW  GLS GL +ECGEGG NLSV                      GQ+QL+CLARAL+R+S++L+LDEATA+VD+ETD L+M T+R+ F  STVIIIAHR+ TI+D+D ++V+++G + E   P++LLA  D  F  L  ++
Sbjct:  226 ECRSSIISRLTFSWLDRSVLNAYRKEIGEA---DVNRLDPSLRVRTVHGEFVRYFPPLVALSRSERDAAEQQENLSFTHHRVNADTEQLVDSGDSEGDQLHSNDSRDGAGGRHRRKLLPALWKAFGSQLILSWSIMMIHGLLAFANPFLLESLINFSTN-GEELWHGILYTFLFFVVAVLSSITFHASFQLSLTCGIKFRSALIASIYRKSLTLTQESRARSTVGEIVNLMTVDSNKIADSIPFFWAMLVSPVQIVIALVMLWAQLGTAVLAGIGIFVVIIPVNGYIMAKAQKLEEKEMKTKDERLKLLNEVLNAMKVIKLYAWEPSFQQKISHVRRTEVGFLGQMSYLFSVVIIMWTVAPFLVMVLTFITYIYSGDDHILTASKAFVSLTLFNILRFPITVLPWTITESVNAYVSIKRIQNFLFEDDIDESSVLKLPSSPDGN-----SVEIEGASFGWKRTDSEPLLKDVNIQVLKGKLIAIVGKVGCGKSSLLQSVLGETVKFCGSITTRGSVAYVPQEAWIQNLTVRDNILFGRDFDQARYDEALRACQLEKDLQLLTAGDATEIGERGINLSGGQKQRVSLARAVYQDSDIYLLDDPLAAVDSHVGKKLFHEVIGKSGLLRDKTRILVTHGIHWLPHVDEIVVID-NGRISEQGSYEHLLDHDGPFASFLKEFFLHDGERKRASRSRDVSVSIAEIAAAAPEEEEEDEELAAEKARILQRLASCTSSAHEVCAESPAVVATSPS---QSPPPH----------------------HVRQMSSSVNSHCSDTADRLDSKRPSIVRQTSKISQLTSEKLPSRDEDVDGTRKAAEQSGRLIDEETMESGSVSLKSYVFYIAARGYHLVLMTIMAHLAYTVVNVASSVWLSTWTSDPLFSNAS--VTGNLNNSAY----LRDINDYYLSIYGIFGVGIVVLVGIYAVMGVYSALRASRSIHKSLLTRLFRVPMSFFDTTPTGRIVNRFSKDMEVVDRELPMIINDFLECFMATVSCIVVISYTTPIFLAAVVPLGIIYAGIQVFYLPISRQSRRLDSRSRSPILTNFSESIAGAAVIRAFRQQQRFVGISDYRVDNNSRFYFLKLASNRWLGFRLELIGTAAVVIAALLAVLGRDSLTPGLVGLSVSYALQISDALNWMVRQLTELETNSVAVERLDEYSNLETEAPWTTDSLPPSGWPSRGRVEFCNYATRYRPGLDLVLQGISVSFEPGHKVGIVGRTGAGKSSLTLGLFRLIESTFGHIEVDGVRIDRLGLHSLRSALTILPQEPTVFSGSLRSNLDPFDERTDEELWAALDAAHLSSWARGLSAGLAHECGEGGTNLSV----------------------GQRQLVCLARALMRRSRLLVLDEATAAVDLETDSLIMATVRQQFADSTVIIIAHRLATIMDSDRVMVLDSGRVREFAPPRDLLAKQDSYFHFLAKEA 1625

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969])

HSP 1 Score: 1018.07 bits (2631), Expect = 0.000e+0
Identity = 592/1535 (38.57%), Postives = 901/1535 (58.70%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDA---------SPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDES-TKNTNILEKIFYD--KIKISHNRKRYDLLQNSTASVAH---LMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDS-WPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSL 4919
            +Y++S  IL IT++LA L  +  R        I+  FWL AT+   +     I++ ++          S + I   L+ +S  +  L     L   FS   KD        PCPE  AS LS++++ W+   + + +++ + ++  + L  +D S T    ++ +  ++  K K + ++  Y   + S A       + E E  L     +S    LF++L R +G   L++  +K +HD  ++  P +L++L++++ +     W GYF            +L     F +  +  +R+R A++G +YRK L + N  R   T GEIVNLMSVDA+R M+ I +     S PLQ++LA+  L+Q +  ++ AG+ ++V   P+N ++    + +   ++K KD RIK++ E+LNGIKVLK+YAWE +F DK++ +R++E+R +L+ +A  G +    W   PFL+ L+TF  YVL  E+N++  +KAFVSL LFN+LRFP+ +LP  ++  + A VS+KR+  +L  EEL+   ++ R  T  +      +I I DG+FSW KED+  L  IN  I  G LVA+VG VG+GKSSL+SA+LGEMH+  G VS++G++AYV Q+AWIQN +L+ENI+F Q+  E +Y+ ++EAC+L  DLE LPGGD TEIGE+G+NLSGGQKQRVSLARAVY +  +YLLDDPLSAVDAHVG+H+FE VI   G+L+ +TR+LVTHGL++LP+ D +LV+  +G I+E GS+ +LL     F  F++ Y       + P G                                  +T     +QRN +                        V +F   +           P       Q +  S +T     +  D   ++L E ++A +G VK A +   +K+ G++L   ++ ++ A     + SN WL  +T+D  I N +Q            S+ +R      + +Y  +GL   + V  Y  S ++G I AS+ +H+ +L +VLRSPM FF+ TPSG ++NRF+K+ + +D +IP  I   +  +F V  S  VI+  TP  AI I PL +LY+ +Q FY+ +SRQ +RL+S++ SPV+ HF ETL G ++IRAF EQQ F   +   +D + K  F    + RWL++R+E +G  +V  A LF+++ R +L+  ++GLSISY+LQ+T  LNWL+R  +E+ETN VA+ER++EY     EAEW L  +   + WP  G+I  +++ LRYRE L L + +I +   GG+K+G+VGRTGAGKSSL L LFR++EAA G I ID +NI+ +GLHDLR R+TI+PQDPV+FSG+LR NLDPF  + D++++++LE AHL+++VSGL + L++EC EGG NLS+                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G++ E DSP +L+A     +K   D  L
Sbjct:  105 VYLVSPTILGITMLLATLLIQYERIKGVQSSGIMLNFWLVATVCATVTFRSKILQAVNEPETVNVFRYSTFYIYYALLLISLILSCLSDQPPL---FSQAVKD------SNPCPEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAPSWHGYFYTALLFVCTCFQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELR-VLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDENSVDRRAITGSAD-----SIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVM-VDGEITETGSYTELLNRQGAFADFLRTYANAEQDGE-PDG----------------------------------MTGKKEKLQRNTT-----------------------FVHFFPRQSQSSLNTPGAAKP-------QQKAESNDTQAKKTKSPDA--AKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTDDPVI-NGTQP-----------SREMR------LGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSL----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYKMAKDSGL 1516

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:103023748])

HSP 1 Score: 1014.99 bits (2623), Expect = 0.000e+0
Identity = 592/1530 (38.69%), Postives = 891/1530 (58.24%), Query Frame = 3

Query:  357 IDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSS----FSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNIL------EKIFYDKIKISHNRKR-YDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFG--VLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +  +Y ++ +I+ +T++LA    +  R        +LFIFW+ + +  ++     I+        N+           F L L+  +  CF+     FS    V+ +  PCPE  A  LS++T+ W  +   K ++  +  +  + L +QD S      L      EK     I+   N +  Y      T  V    E+ + L +    +P      SL + +G   L+  AFK + D   +  P LL++L+E+ +      W G+  A+AF+ FG  +L +L  +  F    +  +R+R A+IG IYRK+L + NE +   T GE+VNLMSVDA+R M+   F     S PLQI+LA+  L+Q +  ++ AG+ ++V   P N ++    + +   ++++KD RIK++ EILNGIKVLK+YAWE SF +K+  +R  E+  + + +    +  + W   PFL+ L TF  YV   + N++  +KAFVSL+LFN+LRFP+ +LP  ++  + A VSLKRI  +L  +EL+       D  D      D A+ + +G FSW K+D   L +IN  + +G L+A+VG VG GKSSL++A+LGEM ++ G +S++G++AYV Q+AWIQN +L++NILF + Y E+ Y  ++EAC+L  DLE LPGGD TEIGE+GINLSGGQ+QRVSLARA+Y   D+YL+DDPLSAVDAHV +H+F++VI   G L+ KTRILVTHG+++LP+VD +LVL   G +SE GS++DLLK    F +F++ Y   +   ++      + +E +              +D +   TD V   PAV   R    R                      +    N      + E+PK+  I       R+  +   +  +  ++K    L++ E A +G VK+  Y    K+ G  L +    +YA+ +   + +NIWL  +T DS     +Q                 E+    + +Y  +G+   ++V F   +  +G I A++ +H+ LL +   +P  FFDTTP GRIINRFSKDI  +D  +P  I   L   F   A++IVI+  TP FA+ I+PLA++Y+ +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+     F  ++   +D++ K  +    S RWL +RIE +G  +V  A +F+++ + +L+  LVGLS+SY+LQ+T  LNW++R  ++LE+N VA+ER++EYS+ P EA W++ +  P   WP+ GN+ F DY +RYREGL LVL+NI+L   GG+KIG+VGRTGAGKSS+ L LFRL+EAAGG I ID + I  IGLHDLR +LTI+PQ+PV+FSGTLR NLDPF  + DD+++ +L  +HL  +VS     L  EC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV  IAHR+NTI+D   I+V++ G+I E D+P NL+A   GIF S+
Sbjct:   96 VPPIYFITPLIVGMTMLLATFIIQFERLRGVQSSGVLFIFWMLSVLCAIVPFRSKILHANKGE--NVDKLRFTTFYMYFGLILVELILCCFNEKPPLFSS---VVTDPNPCPESTAGFLSRMTFWWFTSMAIKGYKSPLETKDLWSLNKQDSSELVVPKLLREWEGEKSKAQSIEQDVNGQAVYSKAGAETNHVEVNPEEVEVLLSSKKDTPQPSFLRSLLKAFGPYFLIGSAFKLLQDLITFINPQLLRMLIEFTKETGVPSWWGF--ALAFMMFGCALLQTLILHQHFQYCFVTGMRLRTAIIGAIYRKSLVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIILALFFLWQTLGPSVLAGVAVMVLLIPFNAVIAMKTRAYQVEQMQYKDARIKLMNEILNGIKVLKLYAWEVSFKEKVLQIRQKELNVLRKTAYLSALSTMAWTSAPFLVALTTFAVYVSVDKNNVLDADKAFVSLSLFNILRFPLNMLPQVISSLVQASVSLKRIQAFLSHDELD------PDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVL-VEGMVSEMGSYQDLLKQNGAFAEFLRNYSLEDIIEEDEVTEVLIDEEESF------------PDDALSNHTDMVDNEPAVNEARRQFMR---------------------QISIMSN------DLENPKTKSIRKRRCSERRPGEPPQEKKEPKVEK----LIQAETAETGRVKFKVYWEYAKAVGPILSLFICFLYASQSAAAIGANIWLSQWTNDSRDSVTAQ-----------------EKVHMRVGVYASLGITQGILVMFSSFTLAMGKIQAARKLHQGLLDNKFHTPQAFFDTTPLGRIINRFSKDIYVIDEALPSTILMFLGTFFASVATMIVIVSSTPIFAVVIVPLALVYFFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGTSVIRAYGRNSAFVLMSDMKVDENQKSYYPGIVSNRWLGIRIEFIGNCIVLFAAVFAVLEKENLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTDWPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSV----------------------GQRQLICLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFEDCTVFTIAHRLNTIMDYTRILVLDKGQIAEFDTPVNLIA-QKGIFYSM 1528

HSP 2 Score: 86.2705 bits (212), Expect = 2.522e-16
Identity = 82/313 (26.20%), Postives = 137/313 (43.77%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNN 4925
            LN L +  + L    V+L+RI+ +    S  E D +N      P++  +T  +    + +  P  L++IN+    G  + VVG  G GKSSL  AL   +E   G I              +R  +  +PQ   I + TLR+N+     + + +    LE   L   +  L  G   E GE G+NLS                       GQ+Q + LARAL  ++ V ++D+  ++VD    + +  H I      +  T I++ H I+ +   D I+V+  G + E+ S ++LL  +    + L + SL +
Sbjct:  589 LNMLPQVISSLVQASVSLKRIQAFL---SHDELDPDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHI-------------SIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLS----------------------GGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVLVEGMVSEMGSYQDLLKQNGAFAEFLRNYSLED 863

HSP 3 Score: 77.7962 bits (190), Expect = 1.124e-13
Identity = 67/284 (23.59%), Postives = 123/284 (43.31%), Query Frame = 3

Query: 1842 TDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISE----------RGSFKDLLKDCN 2624
            +D  +  V+++R+ +Y         E+  +    D  +  +  +E  D S  +++   L L NI+  +  G+ + IVG+ G GKSS+   +   +    G +++ G              +  + QE  + + +L+ N+   + Y++    + +    L   +   P     E  E G NLS GQ+Q + LARA+ +   I +LD+  +A+D      L ++ I      +D T   + H LN +     +LVLD  G I+E          +G F  + KD  
Sbjct: 1256 SDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTD--WPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSVGQRQLICLARALLRKTRILILDEATAAIDLET-DDLIQSTIRTQ--FEDCTVFTIAHRLNTIMDYTRILVLD-KGQIAEFDTPVNLIAQKGIFYSMAKDAG 1533

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:103023748])

HSP 1 Score: 1012.68 bits (2617), Expect = 0.000e+0
Identity = 588/1526 (38.53%), Postives = 883/1526 (57.86%), Query Frame = 3

Query:  357 IDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNIL------EKIFYDKIKISHNRKR-YDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFG--VLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +  +Y ++ +I+ +T++LA    +  R        +LFIFW+       L + C I+      P+                              + +++  NK PCPE  A  LS++T+ W  +   K ++  +  +  + L +QD S      L      EK     I+   N +  Y      T  V    E+ + L +    +P      SL + +G   L+  AFK + D   +  P LL++L+E+ +      W G+  A+AF+ FG  +L +L  +  F    +  +R+R A+IG IYRK+L + NE +   T GE+VNLMSVDA+R M+   F     S PLQI+LA+  L+Q +  ++ AG+ ++V   P N ++    + +   ++++KD RIK++ EILNGIKVLK+YAWE SF +K+  +R  E+  + + +    +  + W   PFL+ L TF  YV   + N++  +KAFVSL+LFN+LRFP+ +LP  ++  + A VSLKRI  +L  +EL+       D  D      D A+ + +G FSW K+D   L +IN  + +G L+A+VG VG GKSSL++A+LGEM ++ G +S++G++AYV Q+AWIQN +L++NILF + Y E+ Y  ++EAC+L  DLE LPGGD TEIGE+GINLSGGQ+QRVSLARA+Y   D+YL+DDPLSAVDAHV +H+F++VI   G L+ KTRILVTHG+++LP+VD +LVL   G +SE GS++DLLK    F +F++ Y   +   ++      + +E +              +D +   TD V   PAV   R    R                      +    N      + E+PK+  I       R+  +   +  +  ++K    L++ E A +G VK+  Y    K+ G  L +    +YA+ +   + +NIWL  +T DS     +Q                 E+    + +Y  +G+   ++V F   +  +G I A++ +H+ LL +   +P  FFDTTP GRIINRFSKDI  +D  +P  I   L   F   A++IVI+  TP FA+ I+PLA++Y+ +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+     F  ++   +D++ K  +    S RWL +RIE +G  +V  A +F+++ + +L+  LVGLS+SY+LQ+T  LNW++R  ++LE+N VA+ER++EYS+ P EA W++ +  P   WP+ GN+ F DY +RYREGL LVL+NI+L   GG+KIG+VGRTGAGKSS+ L LFRL+EAAGG I ID + I  IGLHDLR +LTI+PQ+PV+FSGTLR NLDPF  + DD+++ +L  +HL  +VS     L  EC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV  IAHR+NTI+D   I+V++ G+I E D+P NL+A   GIF S+
Sbjct:   96 VPPIYFITPLIVGMTMLLATFIIQFERLRGVQSSGVLFIFWM-------LSVLCAIV------PF------------------------------RSKILHANKNPCPESTAGFLSRMTFWWFTSMAIKGYKSPLETKDLWSLNKQDSSELVVPKLLREWEGEKSKAQSIEQDVNGQAVYSKAGAETNHVEVNPEEVEVLLSSKKDTPQPSFLRSLLKAFGPYFLIGSAFKLLQDLITFINPQLLRMLIEFTKETGVPSWWGF--ALAFMMFGCALLQTLILHQHFQYCFVTGMRLRTAIIGAIYRKSLVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIILALFFLWQTLGPSVLAGVAVMVLLIPFNAVIAMKTRAYQVEQMQYKDARIKLMNEILNGIKVLKLYAWEVSFKEKVLQIRQKELNVLRKTAYLSALSTMAWTSAPFLVALTTFAVYVSVDKNNVLDADKAFVSLSLFNILRFPLNMLPQVISSLVQASVSLKRIQAFLSHDELD------PDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVL-VEGMVSEMGSYQDLLKQNGAFAEFLRNYSLEDIIEEDEVTEVLIDEEESF------------PDDALSNHTDMVDNEPAVNEARRQFMR---------------------QISIMSN------DLENPKTKSIRKRRCSERRPGEPPQEKKEPKVEK----LIQAETAETGRVKFKVYWEYAKAVGPILSLFICFLYASQSAAAIGANIWLSQWTNDSRDSVTAQ-----------------EKVHMRVGVYASLGITQGILVMFSSFTLAMGKIQAARKLHQGLLDNKFHTPQAFFDTTPLGRIINRFSKDIYVIDEALPSTILMFLGTFFASVATMIVIVSSTPIFAVVIVPLALVYFFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGTSVIRAYGRNSAFVLMSDMKVDENQKSYYPGIVSNRWLGIRIEFIGNCIVLFAAVFAVLEKENLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTDWPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSV----------------------GQRQLICLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFEDCTVFTIAHRLNTIMDYTRILVLDKGQIAEFDTPVNLIA-QKGIFYSM 1486

HSP 2 Score: 85.8853 bits (211), Expect = 3.331e-16
Identity = 82/313 (26.20%), Postives = 137/313 (43.77%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNN 4925
            LN L +  + L    V+L+RI+ +    S  E D +N      P++  +T  +    + +  P  L++IN+    G  + VVG  G GKSSL  AL   +E   G I              +R  +  +PQ   I + TLR+N+     + + +    LE   L   +  L  G   E GE G+NLS                       GQ+Q + LARAL  ++ V ++D+  ++VD    + +  H I      +  T I++ H I+ +   D I+V+  G + E+ S ++LL  +    + L + SL +
Sbjct:  547 LNMLPQVISSLVQASVSLKRIQAFL---SHDELDPDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHI-------------SIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLS----------------------GGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVLVEGMVSEMGSYQDLLKQNGAFAEFLRNYSLED 821

HSP 3 Score: 77.0258 bits (188), Expect = 1.590e-13
Identity = 67/284 (23.59%), Postives = 123/284 (43.31%), Query Frame = 3

Query: 1842 TDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISE----------RGSFKDLLKDCN 2624
            +D  +  V+++R+ +Y         E+  +    D  +  +  +E  D S  +++   L L NI+  +  G+ + IVG+ G GKSS+   +   +    G +++ G              +  + QE  + + +L+ N+   + Y++    + +    L   +   P     E  E G NLS GQ+Q + LARA+ +   I +LD+  +A+D      L ++ I      +D T   + H LN +     +LVLD  G I+E          +G F  + KD  
Sbjct: 1214 SDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTD--WPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSVGQRQLICLARALLRKTRILILDEATAAIDLET-DDLIQSTIRTQ--FEDCTVFTIAHRLNTIMDYTRILVLD-KGQIAEFDTPVNLIAQKGIFYSMAKDAG 1491

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969])

HSP 1 Score: 1010.75 bits (2612), Expect = 0.000e+0
Identity = 593/1539 (38.53%), Postives = 905/1539 (58.80%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDA---------SPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDES-TKNTNILEKIFYD--KIKISHNRKRYDLLQNSTASVAH---LMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESAL--GKAKNLLRQLSDNEDVVEEITDFVLTSP--AVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDS-WPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSL 4919
            +Y++S  IL IT++LA L  +  R        I+  FWL AT+   +     I++ ++          S + I   L+ +S  +  L     L   FS   KD        PCPE  AS LS++++ W+   + + +++ + ++  + L  +D S T    ++ +  ++  K K + ++  Y   + S A       + E E  L     +S    LF++L R +G   L++  +K +HD  ++  P +L++L++++ +     W GYF            +L     F +  +  +R+R A++G +YRK L + N  R   T GEIVNLMSVDA+R M+ I +     S PLQ++LA+  L+Q +  ++ AG+ ++V   P+N ++    + +   ++K KD RIK++ E+LNGIKVLK+YAWE +F DK++ +R++E+R +L+ +A  G +    W   PFL+ L+TF  YVL  E+N++  +KAFVSL LFN+LRFP+ +LP  ++  + A VS+KR+  +L  EEL+   ++ R  T  +      +I I DG+FSW KED+  L  IN  I  G LVA+VG VG+GKSSL+SA+LGEMH+  G VS++G++AYV Q+AWIQN +L+ENI+F Q+  E +Y+ ++EAC+L  DLE LPGGD TEIGE+G+NLSGGQKQRVSLARAVY +  +YLLDDPLSAVDAHVG+H+FE VI   G+L+ +TR+LVTHGL++LP+ D +LV+  +G I+E GS+ +LL     F  F++ Y       + P G    +    L  G    +LRQ   +           L +P  A P Q+ +S+                                      D ++ +  +P   + ++++    NT R                   VK A +   +K+ G++L   ++ ++ A     + SN WL  +T+D  I N +Q            S+ +R      + +Y  +GL   + V  Y  S ++G I AS+ +H+ +L +VLRSPM FF+ TPSG ++NRF+K+ + +D +IP  I   +  +F V  S  VI+  TP  AI I PL +LY+ +Q FY+ +SRQ +RL+S++ SPV+ HF ETL G ++IRAF EQQ F   +   +D + K  F    + RWL++R+E +G  +V  A LF+++ R +L+  ++GLSISY+LQ+T  LNWL+R  +E+ETN VA+ER++EY     EAEW L  +   + WP  G+I  +++ LRYRE L L + +I +   GG+K+G+VGRTGAGKSSL L LFR++EAA G I ID +NI+ +GLHDLR R+TI+PQDPV+FSG+LR NLDPF  + D++++++LE AHL+++VSGL + L++EC EGG NLS+                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G++ E DSP +L+A     +K   D  L
Sbjct:  105 VYLVSPTILGITMLLATLLIQYERIKGVQSSGIMLNFWLVATVCATVTFRSKILQAVNEPETVNVFRYSTFYIYYALLLISLILSCLSDQPPL---FSQAVKD------SNPCPEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAPSWHGYFYTALLFVCTCFQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELR-VLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDENSVDRRAITGSAD-----SIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVM-VDGEITETGSYTELLNRQGAFADFLRTYANAEQDGE-PDGMTDGAPRKTLENGGPAAVLRQSQSS-----------LNTPGAAKPQQKAESN--------------------------------------DTQAKKTKSP--DAAKLTEADKANTGR-------------------VKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTDDPVI-NGTQP-----------SREMR------LGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSL----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYKMAKDSGL 1516

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:103023748])

HSP 1 Score: 1000.35 bits (2585), Expect = 0.000e+0
Identity = 584/1533 (38.10%), Postives = 889/1533 (57.99%), Query Frame = 3

Query:  357 IDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSS----FSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNIL------EKIFYDKIKISHNRKR-YDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFG--VLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVV---CFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +  +Y ++ +I+ +T++LA    +  R        +LFIFW+ + +  ++     I+        N+           F L L+  +  CF+     FS    V+ +  PCPE  A  LS++T+ W  +   K ++  +  +  + L +QD S      L      EK     I+   N +  Y      T  V    E+ + L +    +P      SL + +G   L+  AFK + D   +  P LL++L+E+ +      W G+  A+AF+ FG  +L +L  +  F    +  +R+R A+IG IYRK+L + NE +   T GE+VNLMSVDA+R M+   F     S PLQI+LA+  L+Q +  ++ AG+ ++V   P N ++    + +   ++++KD RIK++ EILNGIKVLK+YAWE SF +K+  +R  E+  + + +    +  + W   PFL+ L TF  YV   + N++  +KAFVSL+LFN+LRFP+ +LP  ++  + A VSLKRI  +L  +EL+       D  D      D A+ + +G FSW K+D   L +IN  + +G L+A+VG VG GKSSL++A+LGEM ++ G +S++G++AYV Q+AWIQN +L++NILF + Y E+ Y  ++EAC+L  DLE LPGGD TEIGE+GINLSGGQ+QRVSLARA+Y   D+YL+DDPLSAVDAHV +H+F++VI   G L+ KTRILVTHG+++LP+VD +LVL   G +SE GS++DLLK    F +F++ Y   +   ++      + +E +              +D +   TD V   PAV   R    R                      +    N      + E+PK+  I       R+  +   +  +  ++K    L++ E A +G VK+  Y    K+ G  L +    +YA+ +   + +NIWL  +T DS     +Q                 E+    + +Y  +G+   +++   C    ++++  + A+   H  +L +VLR+P  FF+ TPSGR++NRFSKD++ +D LIP NI   +   +     ++V   +TP F I I+PL + Y+ +Q FY+ TSRQ +RL+S++ SP+++HF+ET+ G ++IRA+     F  ++   +D++ K  +    S RWL +RIE +G  +V  A +F+++ + +L+  LVGLS+SY+LQ+T  LNW++R  ++LE+N VA+ER++EYS+ P EA W++ +  P   WP+ GN+ F DY +RYREGL LVL+NI+L   GG+KIG+VGRTGAGKSS+ L LFRL+EAAGG I ID + I  IGLHDLR +LTI+PQ+PV+FSGTLR NLDPF  + DD+++ +L  +HL  +VS     L  EC EGG NLSV                      GQ+QL+CLARALLRK+++LILDEATA++D+ETD L+  TIR  F+  TV  IAHR+NTI+D   I+V++ G+I E D+P NL+A   GIF S+
Sbjct:   96 VPPIYFITPLIVGMTMLLATFIIQFERLRGVQSSGVLFIFWMLSVLCAIVPFRSKILHANKGE--NVDKLRFTTFYMYFGLILVELILCCFNEKPPLFSS---VVTDPNPCPESTAGFLSRMTFWWFTSMAIKGYKSPLETKDLWSLNKQDSSELVVPKLLREWEGEKSKAQSIEQDVNGQAVYSKAGAETNHVEVNPEEVEVLLSSKKDTPQPSFLRSLLKAFGPYFLIGSAFKLLQDLITFINPQLLRMLIEFTKETGVPSWWGF--ALAFMMFGCALLQTLILHQHFQYCFVTGMRLRTAIIGAIYRKSLVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIILALFFLWQTLGPSVLAGVAVMVLLIPFNAVIAMKTRAYQVEQMQYKDARIKLMNEILNGIKVLKLYAWEVSFKEKVLQIRQKELNVLRKTAYLSALSTMAWTSAPFLVALTTFAVYVSVDKNNVLDADKAFVSLSLFNILRFPLNMLPQVISSLVQASVSLKRIQAFLSHDELD------PDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVL-VEGMVSEMGSYQDLLKQNGAFAEFLRNYSLEDIIEEDEVTEVLIDEEESF------------PDDALSNHTDMVDNEPAVNEARRQFMR---------------------QISIMSN------DLENPKTKSIRKRRCSERRPGEPPQEKKEPKVEK----LIQAETAETGRVKFKVYWEYAKAVGPILSLFICFLYASQSAAAIGANIWLSQWTNDSRDSVTAQ-----------------EKVHMRVGVYASLGITQGVLILANCLLCRAYSM--LKAAHATHLTMLHAVLRAPQAFFEATPSGRLLNRFSKDVDTIDSLIPDNIDIWMRTFWYTVNVLLVCSALTPMFLIVIVPLMMFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSETITGTSVIRAYGRNSAFVLMSDMKVDENQKSYYPGIVSNRWLGIRIEFIGNCIVLFAAVFAVLEKENLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTDWPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSV----------------------GQRQLICLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFEDCTVFTIAHRLNTIMDYTRILVLDKGQIAEFDTPVNLIA-QKGIFYSM 1529

HSP 2 Score: 85.8853 bits (211), Expect = 3.142e-16
Identity = 82/313 (26.20%), Postives = 137/313 (43.77%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNN 4925
            LN L +  + L    V+L+RI+ +    S  E D +N      P++  +T  +    + +  P  L++IN+    G  + VVG  G GKSSL  AL   +E   G I              +R  +  +PQ   I + TLR+N+     + + +    LE   L   +  L  G   E GE G+NLS                       GQ+Q + LARAL  ++ V ++D+  ++VD    + +  H I      +  T I++ H I+ +   D I+V+  G + E+ S ++LL  +    + L + SL +
Sbjct:  589 LNMLPQVISSLVQASVSLKRIQAFL---SHDELDPDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHI-------------SIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLS----------------------GGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVLVEGMVSEMGSYQDLLKQNGAFAEFLRNYSLED 863

HSP 3 Score: 77.7962 bits (190), Expect = 1.051e-13
Identity = 67/284 (23.59%), Postives = 123/284 (43.31%), Query Frame = 3

Query: 1842 TDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISE----------RGSFKDLLKDCN 2624
            +D  +  V+++R+ +Y         E+  +    D  +  +  +E  D S  +++   L L NI+  +  G+ + IVG+ G GKSS+   +   +    G +++ G              +  + QE  + + +L+ N+   + Y++    + +    L   +   P     E  E G NLS GQ+Q + LARA+ +   I +LD+  +A+D      L ++ I      +D T   + H LN +     +LVLD  G I+E          +G F  + KD  
Sbjct: 1257 SDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTD--WPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSVGQRQLICLARALLRKTRILILDEATAAIDLET-DDLIQSTIRTQ--FEDCTVFTIAHRLNTIMDYTRILVLD-KGQIAEFDTPVNLIAQKGIFYSMAKDAG 1534

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:ZFIN;Acc:ZDB-GENE-050517-16])

HSP 1 Score: 899.042 bits (2322), Expect = 0.000e+0
Identity = 523/1443 (36.24%), Postives = 828/1443 (57.38%), Query Frame = 3

Query:  627 FSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFY-DKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDN-------RSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAER---IMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSG----GQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWL-SLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            FS+ S D    PN   CPEV AS +S+LT+ W        +R+ +     + LR +D  +     L+ ++  ++ +I+   +R  + Q++ A    L   E   +           + P  +  ++LA  +G   L+   +K + D   +A P LL  L+ ++ + S   W GY LA       + +S+  +  F    +  IR+R+AL G++YRK L +    R     GE+  LMSVD +    I N + F W   S PL I LA+  L+Q +  ++ AG+ +++   P N  +   ++      +K +D R++ L+E L+G++++KMYAWE  F D I  +R+ E+  + R +    +    W   PFL+ LA+F  YVL  E++++  E+AFVSL LFNLLR+P+  LP  +++   A VSL+R+  +L  EEL+   ++        +   ++ + I  G+F+W  ++   L++I+  + RG L+A+VG VG+GKSSL++A+LGE++++ GSV+V+G +AYV+Q+AWIQN SL++N+LF +  +E +Y ++++AC+L+ DL  LP GD TEIGE+GINLSGGQ+QRVSLARA+Y    ++LLDDPLSAVDAHVG+H+FE VI  +G+L  +TR+LVTHGL++LP VD ++VL + G +SE GS+ +L+     F + ++ + + +   ++       G H+  +        +L   S+  D+     + V+T P   + R    +                          E S SG                  ++ +S ET  + +    +P S L++ E   +G +K +     +++ G  L    + ++ A     + +N+WL  +  +  + N +Q                   T Y + +Y+ +G   +++          G + A+  +H  LL + L SP+ F+D TP GRIINRFSKD+  +D ++P      L  L     +I++I+  TP F +A IPL ++Y+ +Q FY+ TSRQ +RL+S   SPVF+HF E++ G A +RAF++++ F       +D   +  +    S R + ++ +E LG  +V  A +F+++ R SL A  VGLS+SY++Q+T  ++W++R  +E+E+N VA+ER++EYS+ P EA+W++ +  P   WP+ G++ F+DY  RYREGL LVL+NI+    GG+K+G+VGRTGAGKSSL L L R+VEAA G+I ID ++IS IGLHDLR R+TI+PQDPV+F G+LR+NLDPF  H D E++++LE AHL      L  G+ +EC EGG N SV                      GQ+QL CLARALLR+++VL+LDEATA+VDVETD L+  TIR +F A TV+ IAHR++T+LD   ++V+ +G+IVE DSP  LL+  D  F  +
Sbjct:  179 FSTDSDD----PNL--CPEVGASFISRLTFCWFTRMAVNGYRRGLKMSDLWSLRHKDSCSFVVPHLQAVWRKEQARIA---QRSAVSQSTPAETRKLHTTEKSQSGGAGTEGGATGQEPSLIRAMALA--FGPRYLVGSVYKLLQDILSFASPLLLSHLIRFVGDNSRPTWHGYALAGLMFLCAIATSMLAHQHFHAGFVTGIRLRSALTGLLYRKALMITQAARLSCAGGELTTLMSVDVQHMADITNNLNFVW---SAPLHICLAMYFLWQHLGPSVLAGVAVMLLLIPFNAFIALNIRTLQAQIIKKRDERVRTLSEALSGVRIIKMYAWEGRFRDVILRVREHELAVLGRAAYFSMLSAFTWLCSPFLVALASFGVYVLVDEHHVLDAERAFVSLALFNLLRYPLNQLPQLMSELAMASVSLRRLRNFLSLEELDPHAVDR-----SPSHLRESCVSIEGGTFTWSWDEPPILHDISLAVPRGCLLAVVGTVGSGKSSLMAALLGELNKLGGSVAVKGQVAYVAQQAWIQN-SLRDNVLFGRPLDETWYREVLQACALEQDLLALPAGDNTEIGEKGINLSGGQRQRVSLARAIYSKASVFLLDDPLSAVDAHVGKHIFERVIGPSGLLAGQTRVLVTHGLSFLPHVDRIVVLTA-GRVSESGSYSELMLSGEAFSELLRIHGQGDGAGEDSPASQDDGPHVIIDLRSPGPDEVLSTCSNIADM-----EPVMTEPRRMLMRQLGSQ--------------------------EASGSGT-----------------TQGVSTETRGHKE---TQPGSTLMQPESMETGHMKLSVVLHYLRAVGAPLSTLALLLFCANYTTMLGTNVWLSEWAGEP-VVNGTQ-----------------RNTGYRLGVYSALGAVQSVLSLVMVLMVFKGCLRAAGSLHLALLDNKLHSPISFYDVTPLGRIINRFSKDVFMIDEVLPPTFLMFLGALCNSIFTILIIVISTPVFVVAAIPLVVIYFFVQRFYVATSRQLKRLESTVRSPVFSHFGESVAGAATLRAFRQEERFVIAGDRAVDALQRTSYPSIVSQRRVGAVWLEFLGACVVLFAAMFAVLSRDSLKAGTVGLSVSYAMQVTVVMSWMVRMSSEVESNIVAVERVKEYSETPPEADWEVESCRPPADWPSQGHVEFRDYSTRYREGLDLVLRNISCDIKGGEKVGIVGRTGAGKSSLTLCLLRMVEAASGAIAIDGVDISRIGLHDLRSRITIIPQDPVLFGGSLRDNLDPFGHHSDAEVWEALEFAHLGETARALPGGIQHECAEGGENFSV----------------------GQRQLACLARALLRRTRVLVLDEATAAVDVETDALIQGTIRTHFHACTVLTIAHRLHTVLDCTRVMVLSSGQIVEFDSPDVLLSRKDSAFHKM 1509

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006454.1 (pep scaffold:Pmarinus_7.0:GL483531:32:7621:1 gene:ENSPMAG00000005809.1 transcript:ENSPMAT00000006454.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 354.369 bits (908), Expect = 1.582e-108
Identity = 202/500 (40.40%), Postives = 308/500 (61.60%), Query Frame = 3

Query: 3384 GSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREY-SKIPSEAEWDLNNAP-SDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAG-KSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLL 4874
            G++ AS  +H  L   VLRS M  FDTTP+GR++NRFS+D++ +D  +P      +  + +V   + VI  V PWF +A+IPL +L+ +I        R+ +RLD+I+ SP  +H   +LQG+  I A+ +   F +  Q L+D +    F+   +VRWL++R++I+   ++    L  ++    + A+  GL+ISY++Q+T    + +R  +E E    ++ERI+ Y   +  EA   +   P +  WP +G+++F+D ++RYREGLPLVLK +  +    + +G+VGRTG+G KSSL + LFRLVE  GGSI ID + I  IGL DLR RL+I+PQ+PV+F GT+R NLDP   + D++I+++LE  H++  +  L + L+ E  E G N SV                      G++QLLC+ARA+LR SK+L+LDEATA++D ETD L+  TIR  F   T++ IAHR+NT+L  D I+VM+ G++VE DSP  LL
Sbjct:    3 GTLRASSRLHDSLFLKVLRSSMTVFDTTPTGRLLNRFSRDMDEVDVRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFIRELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLHRYQELLDTNQACLFLFSCAVRWLAVRLDIISVALITTTALMMVLMHGQIPAAYAGLAISYAIQLTGTFQFTIRLASETEARFTSVERIQHYIEALEEEAPDHVPEKPLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSV----------------------GERQLLCVARAILRHSKILLLDEATAAIDTETDTLIQETIRRAFGDCTMLTIAHRLNTVLSCDRIMVMDQGQVVEFDSPSTLL 480

HSP 2 Score: 90.5077 bits (223), Expect = 7.872e-19
Identity = 106/491 (21.59%), Postives = 217/491 (44.20%), Query Frame = 3

Query: 1206 SIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIF-AWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLT----LFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSA-FNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTG-KSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKD 2618
            ++R  + L   ++ K LR +  + +   +G ++N  S D + +   + F A  F+   + ++  + ++     + + A + L V F  +N +    +++   ++       +  +   L G+  +  Y+    FL +   L DT    +   S A   + V  +I+   ++  T L  VL   +  I    A ++++    L    +F + +     +++   F S++RI  Y+  E L     +H      +A +    ++  +D    +++   L L  +   I   + V IVG+ G+G KSSL   +   +    GS+S+ G              ++ + QE  +   +++ N+     Y ++   + +E   +K ++ QLP   ETE+ E G N S G++Q + +ARA+ ++  I LLD+  +A+D      + E +    G   D T + + H LN +   D ++V+D  G + E  S   LL++
Sbjct:    4 TLRASSRLHDSLFLKVLRSSMTVFDTTPTGRLLNRFSRDMDEVDVRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFIRELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLHRYQELLDTNQACLFLFSCAVRWLAVRLDIISVALITTTALMMVLM--HGQIPAAYAGLAISYAIQLTGTFQFTIRLA----SETEARFTSVERIQHYI--EALEEEAPDHVPEKPLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTETDTLIQETIRRAFG---DCTMLTIAHRLNTVLSCDRIMVMD-QGQVVEFDSPSTLLEN 482

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007076.1 (pep scaffold:Pmarinus_7.0:GL480539:10051:22495:1 gene:ENSPMAG00000006379.1 transcript:ENSPMAT00000007076.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 354.369 bits (908), Expect = 5.933e-108
Identity = 206/529 (38.94%), Postives = 319/529 (60.30%), Query Frame = 3

Query: 3294 EQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRF--SLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLL 4874
            +  ++Y+ +Y  +    T+        F  G + A+K IH  LL  VL++P+ FFD TP+GRI+NRFS D+  +D  +P  ++  ++ LF +  +I+V+ Y  PW A+ ++PLA +YY +Q +Y  TSR+ +RL S+  SP+++HF E+L G+A+I+AF+    F   N+  ++ + + +F   + + WL +R++++G ++V +    +++      +   LVGL+I+Y+L I   L+ L+  +T+ ET  V++ER++EY  I SE         S  WP  G +TF    L YR GLP  L  I+   +  +K+G+VGRTG+GKS+L   LFR+V+   G+I ID  +IS + L  LR  L I+PQDP +FS T+R NLDP  S++D E+++ LE  HL+S+V     GL  E  E G + S                       GQ+QLLCLARA+L K+K+L +DEATASVD +TD L+  TIR  F  STV+ IAHR NTILD+D ++V++ G ++E  SP +LL
Sbjct:   16 DPVQFYLSVYGALAAGNTVFTLLRAFLFAYGGVCAAKNIHVTLLHKVLQAPVSFFDATPTGRIMNRFSSDLFTVDDSLPFIMNIFMAQLFGLVGAIVVMCYGLPWMALVLLPLAGVYYCVQKYYRFTSRELKRLGSVTLSPIYSHFAESLSGLAIIKAFRATDRFTRENEARLELNQRCQFAAVAVMHWLDVRLQMMGVVIVVSLAALAVLEHHLRGVDPGLVGLAIAYALGINGRLSGLVSSFTQTETQMVSVERVQEYRGIASEEAHRHPTHVSPDWPQGGALTFDKVFLTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLD-QGGLQAEVAERGRDFS----------------------CGQRQLLCLARAMLFKAKILCIDEATASVDQDTDVLLQKTIRSEFVNSTVLTIAHRPNTILDSDRVLVLQGGRVLEFASPHDLL 521

HSP 2 Score: 88.5817 bits (218), Expect = 4.816e-18
Identity = 113/478 (23.64%), Postives = 210/478 (43.93%), Query Frame = 3

Query: 1290 SGEIVNLMSVDAERIMNWIIFAW-FFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQ--KFSTIELKWKDLRIKILT---------EILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTS----EYNIITPEKAFVSLTLFNLLRF--PMVVLPWGLTDSMNAFVSLKRIGQY--LVGEELNLTEIN-HRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAIL-------GEMHRINGSVS------VQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKS-DLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKD 2618
            +G I+N  S D   + + + F    F++    +V AI+++   + +       + +   PL G+   + +  +F++ ELK    R+  +T         E L+G+ ++K +     F       R+ E R  L     F  V V+  +   L M+   +   L +    E+++   +   V L +   L     +  L    T +    VS++R+ +Y  +  EE +    +   D+    A  +D          +++      LN I+F I   + V IVG+ G+GKS+L S +        G ++  N  +S      ++  +A + Q+ ++ + +++ N+     Y +    +++E C LKS  L+Q  GG + E+ ERG + S GQ+Q + LARA+     I  +D+  ++VD      L + + S      + T + + H  N +   D VLVL   G + E  S  DLL+D
Sbjct:   75 TGRIMNRFSSDLFTVDDSLPFIMNIFMAQLFGLVGAIVVMCYGLPW-------MALVLLPLAGVYYCVQKYYRFTSRELK----RLGSVTLSPIYSHFAESLSGLAIIKAFRATDRFT------RENEARLELNQRCQFAAVAVMHWLDVRLQMMGVVIVVSLAALAVLEHHLRGVDPGLVGLAIAYALGINGRLSGLVSSFTQTETQMVSVERVQEYRGIASEEAHRHPTHVSPDWPQGGALTFDKVF------LTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLDQ--GGLQAEVAERGRDFSCGQRQLLCLARAMLFKAKILCIDEATASVDQDTDVLLQKTIRSE---FVNSTVLTIAHRPNTILDSDRVLVLQ-GGRVLEFASPHDLLQD 523

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001536.1 (pep scaffold:Pmarinus_7.0:GL479104:2125:31869:1 gene:ENSPMAG00000001392.1 transcript:ENSPMAT00000001536.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 333.569 bits (854), Expect = 6.150e-101
Identity = 198/528 (37.50%), Postives = 319/528 (60.42%), Query Frame = 3

Query: 3339 CMTLVVCFYWASFTV--GSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRF--SLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWD--LNNAP-SDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKS 4901
            C  + +CF   S TV    +  ++ +H  +L+ ++ +PM +FDTTP G I+NRFS D   +D  IP  +   +    +  +++ +I YVTP F IA++PLAI YY IQ ++   SR  + LD     P+F+HF+ET++G+  IRAF+ +  F+     L D ++       ++ RWL +R++ +G  +V  A + SI   +  +L+++ VGL ++Y+L ++ +LNW++R   ++E    A++R+    +I +E+ +D  L+ A   D+WP +G I  ++  +RY   L  VLK++N H    +K+G+ GRTG+GKSSL+LA FR+V+   G IIID I+I+ I LH LR RL+I+ QDP++FSG++R NLDP ++  D  ++++L+ A L+  V  L  GLD    E G N SV                      GQ+QL CLARA +RK+ + I+DEATAS+D+ T+ ++   +   F   TV+IIAHR++TIL  D+++V++ G ++E D+P  LLA  D +F S
Sbjct:   11 CSGIALCFI-TSLTVEWTGLKTARNVHNNMLKRIVLAPMRYFDTTPLGHILNRFSADTNIMDQQIPTTLESLMRSALLCLSALGIIAYVTPIFLIALVPLAIAYYFIQKYFRVASRDLQELDDSTQLPLFSHFSETVEGITTIRAFRHEVRFRQRLLELTDANNISYLFLSAANRWLEVRLDYIGACIVLIASVASITDSWNNTLSSARVGLCLTYALMVSNYLNWVVRNLADIEVQMGAIKRVNNLLQIETES-YDGLLSQAQVPDNWPQSGEIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSV----------------------GQRQLFCLARAFVRKTSIFIMDEATASIDMATESILQKVVMTAFANRTVVIIAHRVHTILTADLVMVLKRGSVLEYDTPSTLLA-HDSMFAS 513

HSP 2 Score: 73.9442 bits (180), Expect = 1.505e-13
Identity = 82/379 (21.64%), Postives = 167/379 (44.06%), Query Frame = 3

Query: 1548 TEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSV-------------SVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQ 2645
            +E + GI  ++ +  E  F  ++  L D      L +SAA   + V  + +   I+L   +  +  S  N ++  +  + LT   ++   +  +   L D      ++KR+   L  E  +   +  +    D+ +     I+I + S  +    K  L ++N  I   + V I G+ G+GKSSL  A    +    G +             +++  ++ + Q+  + + S++ N+       +    + ++   LK  ++ LPGG +  + E G N S GQ+Q   LARA  +   I+++D+  +++D      L + V++      ++T +++ H ++ +   D V+VL   GS+ E  +   LL   + F  FV+
Sbjct:  143 SETVEGITTIRAFRHEVRFRQRLLELTDANNISYLFLSAANRWLEVRLDYIGACIVLIASVASITDSWNNTLSSARVGLCLTYALMVSNYLNWVVRNLADIEVQMGAIKRVNNLLQIETESYDGLLSQAQVPDN-WPQSGEIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASIDMATESILQKVVMTA---FANRTVVIIAHRVHTILTADLVMVL-KRGSVLEYDTPSTLLAHDSMFASFVR 516

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ABCC8 (ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59])

HSP 1 Score: 332.798 bits (852), Expect = 5.075e-93
Identity = 202/529 (38.19%), Postives = 311/529 (58.79%), Query Frame = 3

Query: 3339 CMTLVVCFYWASFTVG--SINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRF--SLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIP---SEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            C+ +V+C   +S  V    + A++ +HK+LL  ++R+P+ FFDTTP G I+NRFS D+  +D LIP +    +       +++ VI YVTP F +A++PLA+++Y IQ  +   S+  + LD     P+  H  ET+ G+A IRAF+ +  F+     LID ++       ++ RWL +R++ +G  +V A  + SI   F   L + LVGL ++Y+L ++ +LNW++R   ++E    A++R+    K+     E   +L+  P D WP+ G I       RY   L   LKN++     G+K+G+ GRTG+GKSSL+LALFR+++   GSI ID ++IS I L  LR RL+I+ QDPV+FSG++R NLDP +   D  ++ +LE A L+  V  L  GLD    EGG N S+                      GQ+QL CLARA +R++ +LI+DEATA++D+ T++++   +   F   TV++IAHR+  ILD D+++V+  G + E DSP NLLA  D IF SL
Sbjct: 1069 CLAVVMCLI-SSLAVEWVGLKAARGLHKRLLGRIVRAPLRFFDTTPLGSILNRFSADLHMIDQLIPSSTESLVRSSLFSLSAVSVIAYVTPIFLVALVPLALVHYFIQKHFRIASKDLQELDENTKLPLLLHIMETVDGIATIRAFRHESQFRQRIFELIDANNVPFLFLSAANRWLEVRMDYIGASIVLATAMASITRSFYSGLDSGLVGLGLTYALLVSIYLNWVVRNLADIEVQLQAIKRVNNLMKVEIEDDERSPELHAVPED-WPHRGEIKINRLSARYDASLKPALKNLSSVIQPGQKVGICGRTGSGKSSLSLALFRMLDIFDGSITIDDVDISKIPLSLLRSRLSIILQDPVLFSGSIRFNLDPEARSTDSMLWDALEIAQLKCVVKALPGGLDATVREGGENFSL----------------------GQRQLFCLARAFVRQTAILIMDEATAALDMATEKILQKVVMTAFADRTVVMIAHRVANILDADVVLVLNQGLLEENDSPANLLANPDTIFSSL 1573

HSP 2 Score: 300.827 bits (769), Expect = 6.414e-83
Identity = 203/697 (29.12%), Postives = 346/697 (49.64%), Query Frame = 3

Query:  969 LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDN----------YWI--------GYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEI--RNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCP------LQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNI-ITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYL----VGEELNLTEINHR-------------------------------------DFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSV---------SV-----------------QGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTR--ILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVE 2771
            L+ S+ R +G  ++++   + + D   +  P  +  ++ ++ N              Y+I         Y L++   F  VL        ++      I+ RAA+  MIY K L L+     R K TS  I N+++VD+ ++M      WF   CP      +QI++ + LLY  +  +   G  +I    PL   +   + +   + L+    RIK  +E+++GIK+LK+YAWE+ F   +   R  E+R +   +    +   +   +P   ++ATF+ YV  S  +I ++P  AF SL LF++L  P+ +L   +  ++ A +S++++ ++L    +G+E N  ++  R                                     +FTD S    D AI++  G F+W   +   L +IN  I  G+L  +VG++G GKSSL+SA LGEMH ++GSV         SV                 +G++AY +Q+ WI N +++ENI F   +NE+ Y+ +I  CSL+ D++ LP GD T+IGE+GINLS GQ+QR+S+ARA+YQ+ ++  LDDP +A+D H+  HL  + I   G+L + TR  +LVTH L +L   D ++ +  +G++   G+ KD+     E  +  +E +  N + +       +   +AL + KNL R +   E +V+
Sbjct:  286 LWRSVFRTFGRPIIVSSVLRYMADLLAFTGPLCIYGIVHHLNNDEQQLKPQVRALGVYFISSREFLANAYVLSVLLFFSLVLQRTLLQASYYKAIETGIKFRAAVQTMIYDKILHLSTSSVSRGKMTSRYISNVVTVDSNQLM------WFLFLCPNLWALPVQIIVGVSLLYSLLGVSALIGAAVIALLAPLQYCIATKLARAQKLTLEHSSSRIKQTSELVHGIKLLKLYAWEQVFCSTVEETRSKELRSLSTFAIYTALSTFMNAAIPITAVMATFVTYVHLSSPDITLSPAVAFASLALFHILVTPLFLLSTVVRFAVKALISMQKLTEFLATSEIGDEPNTLDVEPRPKKSSNADVVQMMAVNRKQPQKPVWDDFEPPQDWRQFEFTDGSE---DFAIKVTGGVFTWASSEPSLLTDINICIPHGQLTMVVGQIGCGKSSLLSATLGEMHLVSGSVYWNSSPRQQSVNTKNNRQERRASTFCRRRGSVAYAAQKPWILNSNVQENITFGSPFNEERYKAVINTCSLQPDIDILPQGDRTQIGEKGINLSAGQRQRISVARALYQHTNVVFLDDPFTALDIHLSDHLMHSGIL--GLLHNDTRTVVLVTHKLQYLTHADWIIAM-KDGTVQREGTLKDIQTSDPELYEMWKELM--NKQDEELQKETIIESRTALER-KNLRRAMYSKEVLVK 967

HSP 3 Score: 87.8113 bits (216), Expect = 1.923e-17
Identity = 124/518 (23.94%), Postives = 224/518 (43.24%), Query Frame = 3

Query: 1149 FGVLSSLAENGCFFIT-SILSIRIRAA------LIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQK---FSTIELKWKDLRIKI-----LTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSV-------------QGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKD 2618
            F VL  LA   C   + ++  + ++AA      L+G I R  LR  +        G I+N  S D   I   I       S    +V + +     +S   +     +VA  PL  L+   +QK    ++ +L+  D   K+     + E ++GI  ++ +  E  F  +I  L D      L +SAA   + V  + +   I+LAT +  +  S Y+ +      + LT   L+   +  +   L D      ++KR+   L+  E+   E +         + +   I+I   S  +    K  L N++  I  G+ V I G+ G+GKSSL  A+   +   +GS+++             +  ++ + Q+  + + S++ N+       +    D +E   LK  ++ LPGG +  + E G N S GQ+Q   LARA  +   I ++D+  +A+D    + L + V++      D+T +++ H +  +   D VLVL+  G + E  S  +LL +
Sbjct: 1064 FAVLCCLAVVMCLISSLAVEWVGLKAARGLHKRLLGRIVRAPLRFFDTT----PLGSILNRFSADLHMIDQLIP------SSTESLVRSSLFSLSAVSVIAYVTPIFLVALVPL-ALVHYFIQKHFRIASKDLQELDENTKLPLLLHIMETVDGIATIRAFRHESQFRQRIFELIDANNVPFLFLSAANRWLEVRMDYIGASIVLATAMASITRSFYSGLDSGLVGLGLTYALLVSIYLNWVVRNLADIEVQLQAIKRVNN-LMKVEIEDDERSPELHAVPEDWPHRGEIKINRLSARYDASLKPALKNLSSVIQPGQKVGICGRTGSGKSSLSLALFRMLDIFDGSITIDDVDISKIPLSLLRSRLSIILQDPVLFSGSIRFNLDPEARSTDSMLWDALEIAQLKCVVKALPGGLDATVREGGENFSLGQRQLFCLARAFVRQTAILIMDEATAALDMATEKILQKVVMTA---FADRTVVMIAHRVANILDADVVLVLN-QGLLEENDSPANLLAN 1565

HSP 4 Score: 68.1662 bits (165), Expect = 1.766e-11
Identity = 66/282 (23.40%), Postives = 118/282 (41.84%), Query Frame = 3

Query: 4071 KIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGL-------PLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGS-------------XXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQS-LETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHT---IREYFQASTVIIIAHRINTILDTDIIVVMENGEI 4844
            K P +  WD    P D          +D+ ++   G+       P +L +IN+    G+   VVG+ G GKSSL  A    +    GS                ++           R  +    Q P I +  ++EN+  F S  ++E +++ + T  LQ  +  L +G   + GE G+NLS                      AGQ+Q + +ARAL + + V+ LD+   ++D+     +MH+      +    TV+++ H++  +   D I+ M++G +
Sbjct:  649 KQPQKPVWDDFEPPQDWRQFEFTDGSEDFAIKVTGGVFTWASSEPSLLTDINICIPHGQLTMVVGQIGCGKSSLLSATLGEMHLVSGSVYWNSSPRQQSVNTKNNRQERRASTFCRRRGSVAYAAQKPWILNSNVQENIT-FGSPFNEERYKAVINTCSLQPDIDILPQGDRTQIGEKGINLS----------------------AGQRQRISVARALYQHTNVVFLDDPFTALDIHLSDHLMHSGILGLLHNDTRTVVLVTHKLQYLTHADWIIAMKDGTV 907

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: BPT1 (ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p [Source:SGD;Acc:S000003938])

HSP 1 Score: 685.641 bits (1768), Expect = 0.000e+0
Identity = 465/1382 (33.65%), Postives = 748/1382 (54.12%), Query Frame = 3

Query:  948 NRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWI---GYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLR-DTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFT-DDSAFNYDAAIEIRDGSFSWKKEDKLT----------------------LNNIN-FEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGS--------VSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENV-ISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVF---SNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLC----------MTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIG---RFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAE-WDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGL----SEGLDYECGEGGVN--LSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQ 4913
            NR+  W    ++ + +G  + +A  ++T  D      P  L+I ++ +   + + +    G F+A+      V+S    N  +       + IR +L  ++Y+K+LRL    RN+ ++G+I+NLMSVD  RI  +   A   +  P+QI++ +  LY  +  A+  GL  +    P+N  L   ++K S  ++K+KD+RIK +TE+LN IK +K+YAWE+  + ++ ++R D E++   ++     ++   W  +P ++  +TF  + L S+ + ++P   F SL+LFN+L   +  +P  +   +   VS++R+  +L+ +E++ + I   D + D+ A     AIE+ + +F WK ++ LT                      L NI+ FE  RG LV +VG+VG GKS+ + AILG++  ++GS        +    ++AY SQE+WI N S++ENILF   +++ +Y+  I+AC L  DL+ LP GDET +GE+GI+LSGGQK R+SLARAVY   DIYLLDD LSAVDA V +++ E V I    +LK+KT IL T+ ++ L     +  L+ NG I E+G+++D++   N   +  +   E ++   N +     ++  +  +    L QL   E    E  D V+T   + + + +S R S A+                                    PR    G+Q   + K   +                E+   G VK   Y   IK+ G+   +  V  +      +VF    N WLK ++E ++   +++ + +                  ++ +Y++IG+           M L+ C         SI  SK +H+ + +SV+RSPM FF+TTP GRIINRFS D++ +D  +    S     +     ++I++ Y  PWF +  + L ++Y   Q FYI  SR+ +RL SI+ SP+ +  +E+L G ++I A+   + F  LN   I  +  F F  +S+ RWLS+R++ +G  +V A  + ++     +  L++ +VGL +SYSL++T  L W++R    +ETN V++ERI EY ++P EA+  +    P ++WP+ G I FK+Y  +YRE L  VL NIN+     +K+G+VGRTGAGKS+L+LALFR++E   G IIID I+IS IGL DLR  L I+PQD   F GT++ NLDPF+ + +DE+ +++E AHL+  +  +      G D    +G VN  L V I            N  N +  GQ+QLLCLARALL +SK+L+LDEATASVD+ETD+++  TIR  F+  T++ IAHRI+T+LD+D I+V++ G + E DSP  LL+    IF SL ++
Sbjct:  276 NRNSLWR---AIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGLNPETSSKYPPLNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGLFSLFSD-SPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDDSFIERIDPSADERAL---PAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALE-NGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPL-QLKVTES---ETEDEVVTESELELIKANSRRASLATL----------------------------------RPRPFV-GAQLDSVKKTAQK---------------AEKTEVGRVKTKIYLAYIKACGV---LGVVLFFLFMILTRVFDLAENFWLKYWSESNEKNGSNERVWM------------------FVGVYSLIGVASAAFNNLRSIMMLLYC---------SIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINE----------NGSN-LSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCEK 1554

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YOR1 (Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR) [Source:SGD;Acc:S000003513])

HSP 1 Score: 495.738 bits (1275), Expect = 3.474e-149
Identity = 337/998 (33.77%), Postives = 547/998 (54.81%), Query Frame = 3

Query: 1944 DSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASII-----VIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREY-SKIPSEAEW-DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            + A   D  ++ RDG    +K       ++NF+I +G+ + I G +GTGKSSL++A+ G M + +G V V G +       WIQN S+++NI+F   +N++ Y++++  CSLK+DL+ LP GD TEIGERGI LSGGQK R++LAR+VY+ +DIYL DD LSAVD+ VG+H+ +  ++  G+L +KTRIL TH L+ + +   V+VL ++G + + G+  D LK  N+ +  + ++   N+  ++      ++ E  LG+ K         E  V+E+T+           +  +  +S                        + +NSG          +I+  G  S   SKE     +R ++  IS  +  E   +   KW   ++ +         A + +   F  L  FS++WL  +TE+                     K       +YM +Y+       + +   +       I ASK ++ + ++ +L +PM + DTTP GRI+NRF+KD ++LD+     +++SL  +   FA+I+      I+Y+ PWFAIAI  L +++ LI   Y  + R+ +RL+++  S V+N+  E L G+  I+A++ Q+ F   +  LI+K ++  ++     RW+ + ++++         L  +   F ++A+ VG+ ++Y LQ+   LN +LR  T+ E +  + ER+  Y +++P EA +      P +SWP+ G I F++ D  YR GLP+VLKN+NL+   G+KIG+ GRTGAGKS++  AL+RL E   G I+ID ++IS +GL DLR++L I+PQDPV+F GT+R+NLDPF+   DDE++ +L      +    L E    +  E G +  +   H    +     NF      G++QLL L RAL+R+SK+LILDEAT+SVD ETD  +   I E F   T++ IAHR+ TI++ D I+V+E GE+ E D+P  L +  D IF+S+  +S
Sbjct:  578 NKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLT--GMLANKTRILATHQLSLIERASRVIVLGTDGQV-DIGTV-DELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGE--LGQLK--------YESEVKELTEL----------KKKATEMS------------------------QTANSG----------KIVADGHTS---SKE-----ERAVNS-ISLKIYREYIKAAVGKWGFIALPL--------YAILVVGTTFCSL--FSSVWLSYWTEN---------------------KFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDN----ELTESLRLMTSQFANIVGVCVMCIVYL-PWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIA-KDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNF----SLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSMCSRS 1466

HSP 2 Score: 89.3521 bits (220), Expect = 3.559e-18
Identity = 90/450 (20.00%), Postives = 193/450 (42.89%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSF--DLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRS------DNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWK 2003
            P  + +I+S + + W+   +   +++ +     F  D R   E+  +      I+Y        RK+Y   ++  A+   +ME+         + P   +  +L   +  +  ++  F  + + +    P + K L+E+++ ++       N  IGY +    + F  ++ L  N  F  + +  ++ ++ L     +K    +N  R+ F +G++ + ++ D  RI   + F  F    P  + + I+LL   +      G+G+    F ++     L+  F      + D R+ ++ E+LN IK++K Y WE ++   I ++R  E+  + ++  +   +  +   LP +  L TFL     ++     P   F SL+LF +L   M  LP  +   ++  + L R+   L   E +  ++   +      F+   A+++   SF W+
Sbjct:  109 PLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYY----FEKTRKKYRK-RHPEATEEEVMENA--------KLPKHTVLRALLFTFKKQYFMSIVFAILANCTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMF--VNGLTFNHFFHTSQLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGG-RQPGNIFASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQM--IEMKPSPGFDPKLALKMTHCSFEWE 540

HSP 3 Score: 74.3294 bits (181), Expect = 1.369e-13
Identity = 120/549 (21.86%), Postives = 236/549 (42.99%), Query Frame = 3

Query: 1092 QNRSDNYWIG---YFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPL-QIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWE-ILPFLIMLA-------TFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVV--LPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHR--DFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRIN-----------------GSVSVQGTIAYVSQEAWIQNKSLKENI-LFTQDYNEKFYEDIIEACSL-KSDLE----QLPGGDETE-----------IGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISE 2588
            +NR  ++++G   +F+  AF+F         NG F I   + I     L     ++ L       +    G I+N  + D + + N +  +   ++     IV   ++    + +   A   L+V F  +     +  ++   +E   +      L E+L G+  +K Y  ++ FL K   L       I +++ A  +V VL   +  FL M+A       T LC  +T  + I     A V + L  +L+ P ++  +   +T + N   S +R+  Y    EL L E ++R  + T   ++     I   +  F+++    + L N+N  I  G+ + I G+ G GKS+++SA    ++R+N                 G   ++  +A + Q+  +   ++++N+  F +  +++ ++ ++   ++ K DL     Q P  + T            + E G N S G++Q ++L RA+ +   I +LD+  S+VD      +   ++   G   D T + + H L  +   D +LVL+  G ++E
Sbjct:  927 KNRPPSFYMGLYSFFVFAAFIFM--------NGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFL-------INKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLC--VTRAFPI---SAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTY--ATELPL-EASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSA----LYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFG---DCTILCIAHRLKTIVNYDRILVLE-KGEVAE 1444

HSP 4 Score: 50.8322 bits (120), Expect = 2.207e-6
Identity = 58/250 (23.20%), Postives = 104/250 (41.60%), Query Frame = 3

Query: 4191 LKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENL---DPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNND 4928
             K++N     G+ I + G  G GKSSL       + A  GS+      +   G  DL     ++   P I + ++R+N+    PF+  K DE+   +    L++ +  L  G   E GE G+ LS                       GQK  + LAR++ +K  + + D+  ++VD    + +M   +       T I+  H+++ I     ++V+     V+I +   L A +  +   L   S N++
Sbjct:  604 FKDLNFDIKKGEFIMITGPIGTGKSSL-------LNAMAGSMRKTDGKVEVNG--DL-----LMCGYPWIQNASVRDNIIFGSPFNKEKYDEV---VRVCSLKADLDILPAGDMTEIGERGITLS----------------------GGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKARNQTLINLLQFSSQNSE 814

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YCF1 (Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542])

HSP 1 Score: 448.743 bits (1153), Expect = 2.555e-132
Identity = 272/647 (42.04%), Postives = 397/647 (61.36%), Query Frame = 3

Query: 2988 RQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWA---TYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTV-GSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSI--IGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLS-EGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            R+ S  T  + D   D+ I++    EQ   G VKW     Y+     + + +FI  + I + F  L V  N+WLK+++E                 S Y S         Y+ IY  +G+   L          V  +I+ASK +H  +  SVLR+PM FF+TTP GRI+NRFS DI  +D L+    S        V  +I VI   T  F   IIPL++ Y   Q +Y+ TSR+ RRLDSI  SP+++HF ETL G+A +R + +Q+ F ++NQ  ID +    +   ++ RWL+ R+E++G +++  A   S+  + + +LTA +VGLS+SY+LQIT+ LNW++R   E+ETN V++ERI+EY+ + SEA   +  + P   WP+ G+I F +Y  RYR  L LVLK+IN+H    +K+G+VGRTGAGKSSL LALFR++EA+ G+I+ID I I+ IGL+DLR +L+I+PQD  +F GT+REN+DP + + D+ I+++LE +HL+  V  +S +GLD +  EGG NLSV                      GQ+QLLCLARA+L  SK+L+LDEATA+VDVETD++V  TIR  F+  T++ IAHR+NTI+D+D I+V++NG++ E DSP  LL+ +  +F SL
Sbjct:  905 RRASDATLGSIDFGDDENIAKREHREQ---GKVKWNIYLEYAKACNPKSVCVFILFIVI-SMF--LSVMGNVWLKHWSE---------------VNSRYGSN---PNAARYLAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSV----------------------GQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSL 1505

HSP 2 Score: 416.772 bits (1070), Expect = 2.870e-121
Identity = 245/705 (34.75%), Postives = 393/705 (55.74%), Query Frame = 3

Query:  657 LPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQN----RSDNYWI----------------GYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMN---WIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDT-EMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEI-RDGSFSW--KKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFM-QFVQEYIEHNNRAKNPSG 2687
            L  + P P   A+I S++T+SW+   +   + K + +   + L R   S + +  LEK +                             E++L    N S  W    ++ R +G ++LLA  FK +HD   +  P LL+IL++++ +    R D++                  G+ +A A    G   +   +  F       + I++AL  +IY+K+L L+NE     ++G+IVNLMSVD +++ +   W+   W   S P QI++ +  LY+ +  +++ G+ ++V   PLN  LM + +K    ++K+KD R ++++EILN IK LK+YAWEK + +K+  +R+  E++ + ++     V    + I+PFL+   TF  +V T E   +T +  F +LTLFNLL FP++++P  L   + A VS+ R+  +   EEL    +       +     D AI I  D +F W  K E K+ L NINF+  +G L  IVGKVG+GK++L+S +LG++ R+ G  +V G++AYVSQ  WI N ++KENILF   Y+ +FYE  I+AC+L  DL  L  GD+T +GE+GI+LSGGQK R+SLARAVY   D YLLDDPL+AVD HV +HL E+V+  NG+L  KT++L T+ ++ L   D + +LD NG I+++G++ ++ KD +  + + +  Y + NN   N  G
Sbjct:  204 LTRRKPNPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNW-----------------------------ENELKQKSNPSLSW----AICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIW---SGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSFQFNIVPFLVSCCTFAVFVYT-EDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIG---DVAINIGDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLD-NGEITQQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFG 867

HSP 3 Score: 85.8853 bits (211), Expect = 4.081e-17
Identity = 74/267 (27.72%), Postives = 127/267 (47.57%), Query Frame = 3

Query: 1863 VSLKRIGQYL-VGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSV-------------QGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPG-GDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKD 2618
            VS++RI +Y  +  E  L    HR       +     I+  + S  ++ E  L L +IN  I   + V IVG+ G GKSSL  A+   +    G++ +             +  ++ + Q++ +   +++ENI     Y ++     +E   LK  +  +   G + ++ E G NLS GQ+Q + LARA+     I +LD+  +AVD    + + E + +     KD+T + + H LN +   D ++VLD NG ++E  S   LL D
Sbjct: 1238 VSVERIKEYADLKSEAPLIVEGHRP---PKEWPSQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRT---AFKDRTILTIAHRLNTIMDSDRIIVLD-NGKVAEFDSPGQLLSD 1497

HSP 4 Score: 62.003 bits (149), Expect = 8.655e-10
Identity = 57/230 (24.78%), Postives = 100/230 (43.48%), Query Frame = 3

Query: 4185 LVLKNINLHFHGGKKIGVVGRTGAGKSSLNLA----LFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQ-SLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDR-LVMHTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVE 4850
            + LKNIN     G    +VG+ G+GK++L       LFR+                  G   +   +  + Q P I +GT++EN+  F    D E ++ +++   L   ++ L +G     GE G++LS                       GQK  L LARA+  ++   +LD+  A+VD    R L+ H +         T ++  ++++ +   D I +++NGEI +
Sbjct:  644 VALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRV-----------------KGFATVHGSVAYVSQVPWIMNGTVKENI-LFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLS----------------------GGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNGEITQ 833

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YBT1 (Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication [Source:SGD;Acc:S000003971])

HSP 1 Score: 378.252 bits (970), Expect = 8.406e-108
Identity = 240/666 (36.04%), Postives = 371/666 (55.71%), Query Frame = 3

Query: 2982 QSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWL---FIATVAIYAA--FTGLQVFSNIWLKNFTEDSDIQNASQHI---------LLNISGSPYWSKIIREQ-------TKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            +++++ K      +R  D    +L++EE    G V    Y   +K  G W    F+A++ + A   + G   +   W  +      I  A + I         L++  GS   S    E        T YY+V+Y IIG    L+         V  INAS+ I   +L  VL S + FFD TP+GRI+NRFSKDIE +D  +   I  +   L    +++I+I ++TP F    I ++ILYY +  FY+  SR+ +R +SI+ SP++ HF+ETL GV  IRAF ++  F   N   ID+++K  F    + RWL+ RI+++G L++F A LF +    +L + + G+S++Y++  TE   WL+R Y+E+E N  ++ER++EY +I  E   +    P   WP +G I   D  LRY   LP V+KN++       KIG+VGRTGAGKS++  ALFR +E   G I ID I+IS + L  LR+ +TI+PQDP +FSGT++ NLDP+    D +IF++L+  +L S    L +G   E      + +    +  + + +      + +  GQ+QL+CLAR+LLR  K+++LDEATAS+D  +D  +  TIR+ FQ ST++ IAHR+ +++D D I+VM+ GE+ E D P +LL      F S+ + S
Sbjct:  977 EAKKLQKSLRTEAERTED---GKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLIS-EEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCEHS 1638

HSP 2 Score: 287.73 bits (735), Expect = 6.170e-79
Identity = 207/691 (29.96%), Postives = 333/691 (48.19%), Query Frame = 3

Query:  672 PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFG-VLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRL-------------------------NNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDK-LTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQG----------------TIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLK 2615
            P PE   SI   + ++WLD++++K  +  +  +  + L  QD S             K+K    RKR   L        +L+                               L C +  +     +    LLK +LEY++++S       +  +  +F G +L ++ +    F    + IR+++ +I  IY K LR                          + E  +    G I+NLM++DA ++     +   FL   +  V+A+ LLY+ + +A   G+ +IVA  PLN  L   +       L   D RI+ L E    I+++K ++WE++F   I  +R+ E+  +L  S  + +   LW + P ++  A+F  Y+      + TP  AF +L+LF LLR P+  L   L+  + + VSL R+  +L   +       +   T D   N  A     + + SW K+++   L ++N E   GKL  ++G  G+GK+SL+ A+LGEM+ +NG V V                  +IAY SQ AW+ N ++K NILF   +NE  Y+ ++EAC LK D E L  GD TEIGE+GI LSGGQKQRVSLARA+Y N    LLDD LSAVD+H    +++N I+   +++D+T ILV+H +    +  E++VL  +G + ++G   D+L+
Sbjct:  278 PSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKVK----RKRIFSLNLFFFFSNYLV-------------------------------LQCFWAFLGSVLSFIPTVLLKRILEYVEDQSSAPSNLAWFYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTP-VAFTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFLNENDTK----KYDQLTIDPNGNRFA---FENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCIT-GPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQ 924

HSP 3 Score: 75.485 bits (184), Expect = 7.620e-14
Identity = 110/535 (20.56%), Postives = 224/535 (41.87%), Query Frame = 3

Query: 1122 YFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERI----MNWIIFAWF-FLSCPLQIVLAIILLYQEMSYAIFAG-LGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFP-----MVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQG-------------TIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGD----------------------ETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISE 2588
            Y+L + +L  G   +L   G   +  +  I     +  MI  K L       +   +G I+N  S D E I      +I  A++  + C   ++L   +  Q +S AI    L   V +F + G     +++F +I    +    +  +E L G+  ++ +  E  F+ +  +  D   +    +  A   +    +++  L++    L ++L   +NI   +     ++L   + F      +V L   +  +MN   S++R+ +Y+   E+     N         +  D  IE+ D S  +       + N++F +     + IVG+ G GKS++I+A+   +    G + +               +I  + Q+  + + ++K N+    +++++   + ++  +L S+ EQL  G                        +EI E G NLS GQ+Q + LAR++ ++  I LLD+  +++D      + E +       +  T + + H L  +   D++LV+D+ G + E
Sbjct: 1103 YYLVL-YLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAG--SRELKRFESIS---RSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGL-FIL---FNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMN---SVERVKEYM---EIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLISE-EQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKE---FQGSTILTIAHRLRSVIDYDKILVMDA-GEVKE 1616

HSP 4 Score: 62.7734 bits (151), Expect = 4.721e-10
Identity = 64/270 (23.70%), Postives = 121/270 (44.81%), Query Frame = 3

Query: 4125 PNNGNITFKDYDLRY-REGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLR---KRLTILPQDPVIFSGTLRENL---DPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVET-----DRLVMHTIREYFQASTVIIIAHRIN-TILDTDIIVVMENGEIVEIDSPKNLLAMSDGIF 4895
            PN     F++  + + ++     LK++N+ F  GK   V+G TG+GK+SL +AL   +    G +++  +      + D       +    Q   + + T++ N+    PF+  +   +   +E   L+     L  G   E GE G+ LS                       GQKQ + LARAL   ++ ++LD+  ++VD  T     D  +   + E     T I+++H I  T+ + +++V++E+G + +   P ++L    G+F
Sbjct:  689 PNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAV---VEACGLKRDFEILKAGDLTEIGEKGITLS----------------------GGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLME---DRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDML--QKGLF 928

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: VMR1 (Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication [Source:SGD;Acc:S000001027])

HSP 1 Score: 355.91 bits (912), Expect = 1.203e-100
Identity = 231/648 (35.65%), Postives = 366/648 (56.48%), Query Frame = 3

Query: 3048 QLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVF---SNIWLKNFTEDSDIQ-NASQHIL--LNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDH-LIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSE-------AEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSW-----VSGLSE----------GLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            QL+EEE+  +G +    Y   +K  G   F A  A++A +   Q+     + W++++  D++++ NA    +  L + G    SK  +    YY+ +Y +IG+   ++  F      +  + AS+ I   LL  VL + + FFD TP GRI+NRFSKDIE +D  LIP  +  ++ CL    + I +I  +TP F    + + +LY+ +  +Y+  SR+ +RLDSI  SP+F HF+ETL GV  IRAF +++ F   N   ID++++  F    +V+W S R++++G  +V A+  F ++   ++ + L G+S++Y++  T+   WL+R Y+  E N  ++ER++EYS I  E           L N PS  WP +G I  ++  LRY   LP V++N++       KIG+VGRTGAGKS++  ALFRL+E   G I ID  +IS I L  LR+ +TI+PQDP++F+GT++ N+DP+  + + +IF++L   +L S      V    E           L  E  EGG+NLS                       G++QLL +AR+LLR+ K+++LDEAT+S+D ++D L+   IR  F  ST++ IAHR+ +++D D I+VM+ GE+ E D P  LL    GIF S+
Sbjct:  951 QLIEEEEKSNGAISPDVYKWYLKFFGG--FKALTALFALYITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKN-KHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPY-LEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQENYLGHDEGRILLLNEPS--WPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLS----------------------QGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLKDERGIFYSM 1570

HSP 2 Score: 286.189 bits (731), Expect = 1.438e-78
Identity = 228/711 (32.07%), Postives = 355/711 (49.93%), Query Frame = 3

Query:  672 PCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQN--RSDN-------YWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTS--------------GEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKED------KLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSV----------------QGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNR 2669
            P  E  +SILS +T+SW+  +I+                   E+ KNT  L+ I+     +S       +L+  T    H+                  L ++L   +   LL+   +  V+         L+K  LE + N  RS +       Y IG F  I  L   + +S  +    F++  + +RIRA LIG IY K LR     R  FTS              G I+NL+S+D+ ++     + +  +   + I++ + LL+  +  + FAG+ +I+  FPLN LL NL+ KF    LK  D RI  L E L  I+++K +AWE++ +++I ++R  E+R +L+ S  + V   LW + P L+   TF         ++  P  AF +L+LF LL+ P+  L   L+    + VSLKRI  +L  ++    + N    + D        IE ++ + +W + D      KL   NI F+IG  KL  I+G  G+GKS+L+  +LGE++ I+GS+ V                  + AY SQ AW+ N ++K NI+F   YNE  Y  +I+AC LK DLE LP GD TEIGE+GI LSGGQKQR+SLARAVY +    LLDD LSAVD+H    ++EN I+   ++K++T ILVTH ++   +     ++  NG +  +G+  +L         F ++Y++ ++R
Sbjct:  266 PSREHISSILSCITWSWITNFIW-------------------EAQKNTIKLKDIW----GLSMEDYSIFILKGFTRRNKHINN----------------LTLALFESFKTYLLIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNRSSSCMNLAWLYIIGMF--ICRLTLAICNSQGQ----FVSDKICLRIRAILIGEIYAKGLR-----RRLFTSPKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAP-LAFTTLSLFTLLKTPLDQLSNMLSFINQSKVSLKRISDFLRMDDTE--KYNQLTISPDKN-----KIEFKNATLTWNENDSDMNAFKLCGLNIKFQIG--KLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCIT-GPLMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKG----LFKEKYVQLSSR 911

HSP 3 Score: 86.6557 bits (213), Expect = 2.541e-17
Identity = 121/562 (21.53%), Postives = 246/562 (43.77%), Query Frame = 3

Query: 1041 FSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWII-FAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLT---LFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRD----FTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQG-------------TIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKS--DLEQLPGGDE-------------TEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKD 2618
            F++  +P  LK + +  +N+ + +   Y+L + FL  G++ ++       +T +  +R    +   +    L       +    G I+N  S D E +   +I +    + C +Q    I L+       +   + + V +F +    +   ++   ++   K    +  +E L G+  ++ +  E+ F+ +  N  D   R    +S          +++   I+LA+   ++L +  NI     A +SLT   LF      +V L      +MN   S++R+ +Y   E+ N   + H +      ++ ++  D  IEI + S  +       + N++F++     + IVG+ G GKS++I+A+   +  I G + + G             +I  + Q+  +   ++K N+    +Y+EK     +   +L S  + E++   +E             TEI E G+NLS G++Q + +AR++ +   I LLD+  S++D +   HL + +I +       T + + H L  +   D ++V+D+ G + E     +LLKD
Sbjct: 1018 FAMDTLP--LKGMTDSSKNKHNAF---YYLTVYFLI-GIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASG-SFILLNIANI-DSGLAGISLTYAILFTDGALWLVRLYSTFEMNMN---SVERLKEYSSIEQENY--LGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSID-YDSDHLIQGIIRSE--FNKSTILTIAHRLRSVIDYDRIIVMDA-GEVKEYDRPSELLKD 1562

HSP 4 Score: 57.3806 bits (137), Expect = 2.280e-8
Identity = 74/306 (24.18%), Postives = 134/306 (43.79%), Query Frame = 3

Query: 4041 VALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREG----LPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHD---LRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHT--IREYFQASTVIIIAHRIN-TILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNND 4928
            V+L+RI ++ ++    ++   N  + S P+   I FK+  L + E         L  +N+ F  GK   ++G TG+GKS+L L L   +    GSII+  +      + D   L        Q   + + T++ N+   + + +D   + ++   L+  +  L  G   E GE G+ LS                       GQKQ + LARA+   +K ++LD+  ++VD  T   +          +  T I++ H ++ T+ +    +V+ENG++    +   L   S G+FK  + Q  + D
Sbjct:  635 VSLKRISDFLRMDDTEKY---NQLTIS-PDKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLS----------------------GGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGPLMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITEL--QSKGLFKEKYVQLSSRD 912

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO36474 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SII0])

HSP 1 Score: 968.763 bits (2503), Expect = 0.000e+0
Identity = 544/1315 (41.37%), Postives = 817/1315 (62.13%), Query Frame = 3

Query: 1002 ELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYI---LRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQL-SDNEDVV---EEITD----FVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAF--TGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +  LA  FK + D   +  P +L++++ +++  S + W GY  A+         S+  +  F I     I+I+ AL G+IY K LRLN+  RNK T+G++VNLMSVDA+R+++   +     S PLQIV+A+  LY  M ++I AG+ ++V   P N ++    +K    ++  KD RI+I+ EILNG+KVLK+YAWE+SF+ K+T +R+ E+ ++   + ++A FG     +   PFL+ LATF  YVLT   NI+T   AFV+++LFN+LRFP+ VLP  +   + A VSLKR+ ++L  +EL+ T ++ +  +  S    + AI + DGSFSW    + TL+NIN  I  G LVA+VG+VG GKS+L+SA+LGE  ++ G V V+G++AYV Q+AWIQN +L++N++F ++++ + Y   I+ C+L++D + LP GD TEIGERGINLSGGQKQRV+LARAVY N D+YLLDDPLSAVD+HVG+H+F+ VI   G L+ KTR+LVTHG+++LP+VD+++VL  +G +SE G++K+LL +   F +F++ +                 +E +   A  +LR++  D ED++   + I D    F+   P  PI+R                                            ++  ++T G+     + +TD  T    D+ +  ++ EE+A +G+VKW  +    KS G+  FIA++ I       G  V S IWL  ++ D+D  +A++ + L                 Y    +      +   +C  +     GS+ AS+ IH  LL ++  +PM FF+TTP GR++NRFSKD+  +D  +P + S  L        ++  I Y TP F   IIPL I+Y LIQ  Y+ +SRQ +R++S++ SP++N+F ET+ G + IRA+ +QQ F   N   +D++    +    S RWL LR+E +G L++F A LF+++GR S+ ++LVG+SI+Y+LQIT+ LN ++RQ +ELETN V++ER +EY+ + +EAEW + ++ P   WP+ G I  +D+DLRYR  LPLVLKNI++    G+KIG+VGRTGAGKS+L LALFR++E+AGG I++D ++IS +GL DLR  LTI+PQDPV+FSGTLR NLDPF ++ D+++++ LE +HL+++ SGL EGL +   EGG NLSV                      GQ+QL+CLARALLRKSKVL+LDEATA+VD+ETD L+ +TIR  F   TV  IAHR+NTI+D   I+V++ G ++E DSP+NL+A   GIF  +
Sbjct:   15 QFFLAAFFKLIQDSMSFVQPTILRLMISFVEGNSPS-WEGYMYALIMFAAAAFQSILLHAYFHIVISAGIKIKTALTGLIYSKALRLNSVSRNKSTAGDMVNLMSVDAQRVLDMCTYINLLWSGPLQIVVALYFLYDTMGWSIVAGVVVMVLLIPFNLVVTRFSRKLQLKQMANKDSRIRIMNEILNGMKVLKLYAWEESFMAKVTGIRNQELHHLKNAMYLNAFFGFT---FTCAPFLVSLATFAIYVLTG--NILTANNAFVAISLFNILRFPLTVLPNVIISYVQAQVSLKRLTKFLTLDELDETNVHKKMPSHIS----NQAIHVDDGSFSWDVTGQPTLHNINLNIPDGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVL-QDGRVSEVGTYKELLANRGAFAEFLKTFA---------------PEEKSGDAALKVLREVPEDEEDILVRLQAIGDEDEMFMEPEPQ-PIRRRG------------------------------------------RANSVVTIGTTITSDTADTDCMTIMEEDREVDHMIGEEKAATGSVKWVVFWAYAKSIGV--FIASIVILFMILSEGALVGSRIWLAAWSADNDTSDATRDMYLG---------------GYAAFGFFQAFFVLVSSICLAF-----GSVRASRSIHDSLLIAIFHAPMSFFETTPLGRVVNRFSKDLYVVDDTVPRSTSGFLRTALSAIGTLFAITYATPLFLSVIIPLGIVYVLIQRLYVASSRQLKRIESVSKSPIYNNFFETISGTSTIRAYHQQQRFIRGNYYKVDENQLAYYPLVVSNRWLGLRLEFVGNLIIFFAALFAVVGRDSIESALVGMSITYALQITQTLNMMVRQTSELETNIVSVERTKEYADMETEAEWVVEDSRPPKGWPDKGRIQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISKMGLQDLRSSLTIIPQDPVLFSGTLRFNLDPFDAYSDEDLWEVLEVSHLKAFASGLPEGLLHPIAEGGENLSV----------------------GQRQLVCLARALLRKSKVLVLDEATAAVDLETDELIQNTIRTEFAERTVFTIAHRLNTIMDYSRILVLDKGFMMEFDSPQNLIAQR-GIFYGM 1215

HSP 2 Score: 85.5001 bits (210), Expect = 1.478e-16
Identity = 65/240 (27.08%), Postives = 112/240 (46.67%), Query Frame = 3

Query: 1971 IEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSV-------------QGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSN---------GSISERGSFKDLLKDCN 2624
            I+I D    ++    L L NI+ +I  G+ + IVG+ G GKS+L  A+   +    G + V             + ++  + Q+  + + +L+ N+     Y+++   +++E   LK+    LP G    I E G NLS GQ+Q V LARA+ +   + +LD+  +AVD    + L +N I       ++T   + H LN +     +LVLD             I++RG F  + +D  
Sbjct:  984 IQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISKMGLQDLRSSLTIIPQDPVLFSGTLRFNLDPFDAYSDEDLWEVLEVSHLKAFASGLPEGLLHPIAEGGENLSVGQRQLVCLARALLRKSKVLVLDEATAAVDLETDE-LIQNTIRTE--FAERTVFTIAHRLNTIMDYSRILVLDKGFMMEFDSPQNLIAQRGIFYGMAQDAG 1220

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO35071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMJ8])

HSP 1 Score: 451.44 bits (1160), Expect = 1.194e-136
Identity = 239/573 (41.71%), Postives = 370/573 (64.57%), Query Frame = 3

Query: 1065 LLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRI---KILTEILNG-IKVLKMYAWEKSFLDKITNLRDTEMRYI---LRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNED 2762
            L+++++ +++  S + W GY  A+         S+  +  F I     I+I+ AL G+IY K LRLN+  RNK T+G++VNLMSVDA+R+++   +     S PLQIV+A+  LY  M ++I AG+ ++V   P N ++    +K    +     + +    +    L G  KVLK+YAWE+SF+ K+T +R+ E+ ++   + ++A FG     +   PFL+ LATF  YVLT   NI+T   AFV+++LFN+LRFP+ VLP  +   + A VSLKR+ ++L  +EL+ T ++ +  +  S    + AI + DGSFSW    + TL+NIN  I  G LVA+VG+VG GKS+L+SA+LGE  ++ G V V+G++AYV Q+AWIQN +L++N++F ++++ + Y   I+ C+L++D + LP GD TEIGERGINLSGGQKQRV+LARAVY N D+YLLDDPLSAVD+HVG+H+F+ VI   G L+ KTR+LVTHG+++LP+VD+++VL  +G +SE G++K+LL +   F +F++ +             +   D S    A+ + RQ++  ++
Sbjct:    1 LIRLMISFVEGNSPS-WEGYMYALIMFAAAAFQSILLHAYFHIVISAGIKIKTALTGLIYSKALRLNSVSRNKSTAGDMVNLMSVDAQRVLDMCTYINLLWSGPLQIVVALYFLYDTMGWSIVAGVVVMVLLIPFNLVVTRFSRKLQVCQFILIGVSLCQPPLCRCCLWGSCKVLKLYAWEESFMAKVTGIRNQELHHLKNAMYLNAFFGFT---FTCAPFLVSLATFAIYVLTG--NILTANNAFVAISLFNILRFPLTVLPNVIISYVQAQVSLKRLTKFLTLDELDETNVHKKMPSHIS----NQAIHVDDGSFSWDVTGQPTLHNINLNIPEGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQ-DGRVSEVGTYKELLANRGAFAEFLKTFAPEEKSGDAAREQESCPDNSQ--GARVMSRQIAREQE 560

HSP 2 Score: 321.627 bits (823), Expect = 1.666e-91
Identity = 197/505 (39.01%), Postives = 298/505 (59.01%), Query Frame = 3

Query: 2943 EDPKSPRIMTPGSQSRQISKETDQNTD------------RLIDKPISQLVEEEQAMSGT--------VKWATYSMCIKSRGLWLFIATVAIYAAF--TGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNA-PSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQ 4388
            ++ +  R+M     SRQI++E +   D            R     ++QL   +   S T        VKW  +    KS G+  FIA++ I       G  V S IWL  ++ D+D  +A++ + L                 Y    +      +   +C  +     GS+ AS+ IH  LL ++  +PM FF+TTP GR++NRFSKD+  +D  +P + S  L        ++  I Y TP F   IIPL I+Y LIQ  Y+ +SRQ +R++S++ SP++N+F ET+ G + IRA+ +QQ F   N   +D++    +    S RWL LR+E +G L++F A LF+++GR S+ ++LVG+SI+Y+LQIT+ LN ++RQ +ELETN V++ER +EY+ + +EAEW + ++ P   WP+ G I  +D+DLRYR  LPLVLKNI++    G+KIG+VGRTGAGKS+L LALFR++E+AGG I++D ++IS +GL DLR  LTI+PQ
Sbjct:  564 DNSQGTRVM-----SRQIAREQESCPDNSQGTRRKTLRSRYFTSKVAQLRHAKPMDSITWSPYISFQVKWVVFWTYAKSIGV--FIASIVILFMILSEGALVGSRIWLAAWSADNDTSDATRDMYLG---------------GYAAFGFFQAFFVLVSSICLAF-----GSVRASRSIHDSLLIAIFHAPMSFFETTPLGRVVNRFSKDLYVVDDTVPRSTSGFLRTALSAIGTLFAITYATPLFLSVIIPLGIVYVLIQRLYVASSRQLKRIESVSKSPIYNNFFETISGTSTIRAYHQQQRFIRGNYYKVDENQLAYYPLVVSNRWLGLRLEFVGNLIIFFAALFAVVGRDSIESALVGMSITYALQITQTLNMMVRQTSELETNIVSVERTKEYADMETEAEWVVEDSRPPKGWPDKGRIQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISRMGLQDLRSSLTIIPQ 1041

HSP 3 Score: 76.6406 bits (187), Expect = 8.481e-14
Identity = 64/237 (27.00%), Postives = 106/237 (44.73%), Query Frame = 3

Query: 4176 GLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLA 4877
            G P  L NINL+   G  + VVG+ G GKS+L  AL    E   G +              ++  +  +PQ   I + TLR+N+    +       ++++   L++    L  G   E GE G+NLS                       GQKQ + LARA+   + V +LD+  ++VD    + +   +   R   +  T +++ H I+ +   D IVV+++G + E+ + K LLA
Sbjct:  313 GQP-TLHNINLNIPEGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVY-------------VKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLS----------------------GGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQDGRVSEVGTYKELLA 513

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO43433 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYB6])

HSP 1 Score: 386.726 bits (992), Expect = 4.060e-121
Identity = 200/416 (48.08%), Postives = 285/416 (68.51%), Query Frame = 3

Query: 3660 FYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
             ++ TSRQ +RL+S++ SP+++HF E++ G  +IRAF++Q+ F   + + +D +    +      RWLSLR+E+LG  ++  A LF+++ R  +   LVGLS++Y+LQIT  L WL+RQ +ELETN VA+ERI+EYS+ P+EA W +    P   WP  G++  +  D+RYR+  P V+K +    + G+KIG+VGRTGAGKS+L+LALFR++E A G I+ID I+I+ IGL DLR RLTI+PQD V+FSG+++ NLDPF S  D+E+++ LE  HL+S+VS L +GL ++  EGG NLS                      AGQ QL+CLARALLRKSKVL+LDEATA+VD+ETD L+ +TIR  F   TV+ IAHR+NTI+D   I+V++ G I+E D+P  LLA   G+F  +
Sbjct:    2 LFVSTSRQLKRLESVSRSPIYSHFYESITGCTIIRAFRQQRRFVQESNSKVDHAQMANYPSLCINRWLSLRLELLGAAVLLFAALFAVVSRGRIAPGLVGLSVAYALQITGVLTWLVRQSSELETNIVAVERIKEYSETPTEAAWVIPGRRPPADWPQEGHVAVESLDMRYRDDQPPVIKKLTFEINSGEKIGIVGRTGAGKSTLSLALFRILERASGKIVIDNIDINKIGLQDLRSRLTIIPQDAVLFSGSVKLNLDPFESTCDEELWRVLEAVHLKSFVSSLQDGLMHQIQEGGENLS----------------------AGQCQLVCLARALLRKSKVLVLDEATAAVDLETDELIQNTIRTEFADRTVLTIAHRLNTIMDYTRIMVLDEGSILEFDTPSALLAQK-GVFHEM 394

HSP 2 Score: 85.8853 bits (211), Expect = 2.114e-17
Identity = 66/233 (28.33%), Postives = 114/233 (48.93%), Query Frame = 3

Query: 1998 WKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSV-------------QGTIAYVSQEAWIQNKSLKENI-LFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSI----------SERGSFKDLLKDCN 2624
            ++ +    +  + FEI  G+ + IVG+ G GKS+L  A+   + R +G + +             +  +  + Q+A + + S+K N+  F    +E+ +  ++EA  LKS +  L  G   +I E G NLS GQ Q V LARA+ +   + +LD+  +AVD    + L +N I       D+T + + H LN +     ++VLD  GSI          +++G F ++ KD  
Sbjct:  172 YRDDQPPVIKKLTFEINSGEKIGIVGRTGAGKSTLSLALFRILERASGKIVIDNIDINKIGLQDLRSRLTIIPQDAVLFSGSVKLNLDPFESTCDEELWR-VLEAVHLKSFVSSLQDGLMHQIQEGGENLSAGQCQLVCLARALLRKSKVLVLDEATAAVDLETDE-LIQNTIRTE--FADRTVLTIAHRLNTIMDYTRIMVLD-EGSILEFDTPSALLAQKGVFHEMAKDAG 399

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO35250 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM18])

HSP 1 Score: 377.096 bits (967), Expect = 3.465e-113
Identity = 229/624 (36.70%), Postives = 356/624 (57.05%), Query Frame = 3

Query: 3048 QLVEEEQAMSGTVKWATY-SMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSII--GRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            +++E E+   G++    Y  +          +    ++ A  G    ++ WL ++++    QN        ++ SPY         +YY+ +Y  + L   L+       F    + ASK +H K+  +VLR+PM FFDT P+GRIINRFSKDI  +D L+P    + +S   + FA ++V +   PW  I I+PLA+ +  ++ +Y+ TSR+ +R+++I  +P+FNHF+ TL+G+A IR+   Q           D  S+  F+  ++ RWL++R+E+L  L V  A    +       + A +VGL++SY++ +T    W +R   E+E    A+ER+ +YSK+  E EW  + ++ P   WP +G IT +   L+Y   LP VLKN+       +K+G+VGRTG GKSSL  AL RLVE  G  + ID ++I+ IGLHDLR +++++PQDPV+FSG+LR NLDP S +KD+E++ +L+   L   V    +GLD +  E G N SV                      GQ+QL+CLARALLR++ +LI+DEATA VD  TD L+  TIR  F+  TV+ IAHR+NTI+D D ++V++NG++VE + P  +L   + +F  L
Sbjct:  144 EMLEPEERPRGSIPVKLYLDLFYAGANCCTLVFMSVLFFAAQGSYTITDWWLAHWSDIDYKQNLLNETSGIVTQSPY-------DRRYYIAVYGGLVLLTFLLSFIRSFLFFYVKVAASKALHNKMFCAVLRAPMYFFDTNPAGRIINRFSKDIGFMDDLLPETFYEFISLAILCFAVVVVNVATMPWVIIGILPLAVAFLFVRSYYLKTSREVKRIEAIGRTPIFNHFSSTLEGLATIRSLSSQTQVTAELAACQDHHSEAWFLFIATSRWLAIRLEMLCLLFVTMAAFTPLFLSRNHDIDAGVVGLTLSYAVMLTGMFQWCVRMSAEVENQMTAVERVVDYSKVEPEGEWHKECSDVPP-IWPVHGLITAESLSLQYHATLPRVLKNMCFCVRPKEKVGIVGRTGTGKSSLLAALIRLVEPKG-IMRIDGVDITDIGLHDLRSKISVIPQDPVLFSGSLRHNLDPVSQYKDEELWTALKEVQLGDAVLEFPDGLDTKVTESGNNFSV----------------------GQRQLICLARALLRRNVILIIDEATAHVDQRTDALIQKTIRSKFKDCTVLTIAHRLNTIMDMDRVMVLDNGKLVEFEEPFVMLLNPESVFSKL 736

HSP 2 Score: 82.4185 bits (202), Expect = 1.153e-15
Identity = 61/221 (27.60%), Postives = 109/221 (49.32%), Query Frame = 3

Query: 2022 LNNINFEIGRGKLVAIVGKVGTGKSSLISAIL-----GEMHRINGS-------VSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQE 2648
            L N+ F +   + V IVG+ GTGKSSL++A++       + RI+G          ++  I+ + Q+  + + SL+ N+     Y ++     ++   L   + + P G +T++ E G N S GQ+Q + LARA+ +   I ++D+  + VD      + + + S     KD T + + H LN +  +D V+VLD+   +     F  LL   + F + V E
Sbjct:  522 LKNMCFCVRPKEKVGIVGRTGTGKSSLLAALIRLVEPKGIMRIDGVDITDIGLHDLRSKISVIPQDPVLFSGSLRHNLDPVSQYKDEELWTALKEVQLGDAVLEFPDGLDTKVTESGNNFSVGQRQLICLARALLRRNVILIIDEATAHVDQRTDALIQKTIRSK---FKDCTVLTIAHRLNTIMDMDRVMVLDNGKLVEFEEPFVMLLNPESVFSKLVAE 739

HSP 3 Score: 81.6481 bits (200), Expect = 1.812e-15
Identity = 44/109 (40.37%), Postives = 63/109 (57.80%), Query Frame = 3

Query: 2379 RAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSD 2705
            RAVY N D+YLLDDPLS+VD HVG+HLF+  I   G++KD  RILVTH L +L    E+L L   G +   G++ +L     +F   ++   E      + + G+  +D
Sbjct:    1 RAVYYNADVYLLDDPLSSVDTHVGRHLFDACIC--GLIKDCPRILVTHQLQYLHSATEILCL-KEGRVLGIGTYTELTTSGIDFTTLIKTKPEAEETDADSAIGEDTND 106

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO46846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RP39])

HSP 1 Score: 391.349 bits (1004), Expect = 4.142e-113
Identity = 237/658 (36.02%), Postives = 373/658 (56.69%), Query Frame = 3

Query: 3033 DKPIS--QLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISG-------SPYWSKIIR------EQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRF--SLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREY-SKIPSEAEWDLNNAPSD----------------SWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            D+P    +LVEEE    G V+   Y    ++ G  L  + +       G +   + WL  +   S I +      +           +PY +  +R         K+Y+V+Y  I +  T+   F    F  G I A+K IH++LL S+L +P+ FFD TP GRIINRFS D+ ++D  +P  ++  L+  + V AS+++  Y  PW A+ + PL I+YY +Q +Y  TSR+ +R+ ++  SP++ HF+ETL G++ IRA +  Q F+  N+  ++ + +  + +  +  WL LR++ +G  +       +++     ++   LVGL++SY+L +T+ +  ++  + E E   V++ER  +Y ++IP E         +                 SWP +G I F +  L YR GLP  L+N++L  H G+K+G+VGRTG+GKSSL L LFR+VE A G++I+D +NI+++ L  LR RL I+PQDP +FSG++R+N+DP+    D +++ +LE  HLQ  VS L  GLD E GE G N S                      AGQ+QL+CLARA+L ++K+L +DEATASVD+ETDR +  TIRE F+ STV+ IAHRI+T++D+D ++VM  G + E + P  L+A  + +F SL
Sbjct:  708 DEPTGDGRLVEEEAKDVGAVRLHVYGSYWRAIGHCLATSILLSLLLMQGSRTIGDWWLAYWISHSKIDHTDNATTITHHSHDSTHPEAPYAAPFLRGVNIKKNTLKFYLVVYAGIAVANTVFTLFRAFLFAYGGIKAAKTIHQRLLSSILAAPISFFDITPIGRIINRFSSDVYSIDDSLPFMLNIFLAQAYFVVASLVITCYGLPWMALLVAPLMIIYYYLQGYYRKTSRELKRIITVTESPIYAHFSETLTGLSTIRALRHTQRFRTENEERLEVNQRANYCEMVAYVWLVLRLQGIGVAINAGVAFLAVLEHHFHTVDPGLVGLAMSYALSVTQSIADMVNSFAETEKQMVSVERAEQYITRIPVEKPGGSKVCHAHILLLSSLSDISRLLSSSWPTHGRIRFHNIVLVYRPGLPPALRNVSLEIHAGEKVGIVGRTGSGKSSLFLVLFRMVEVAEGAVILDGVNIASLPLDKLRSRLAIIPQDPFLFSGSVRDNIDPWGKCSDRDLWITLERCHLQQPVSDLG-GLDAEVGERGRNFS----------------------AGQRQLVCLARAMLTRAKILCIDEATASVDMETDRFIQRTIREAFRTSTVLTIAHRIDTVMDSDRVLVMNKGTVTEFEKPDTLMANQNSLFYSL 1342

HSP 2 Score: 343.969 bits (881), Expect = 3.541e-97
Identity = 233/622 (37.46%), Postives = 345/622 (55.47%), Query Frame = 3

Query:  969 LFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCV-LWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWK-----KEDKLT-------------------LNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSV---QGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNN------------RAKNPSGGQHLSDESA 2714
            L   L   +GL+       K   D   ++ P LL  L+ +++N+++    GY+ A+  L   +L++L      +    +S +IRAA+I  +Y KTL ++     KF+SGE++N MS D +R++N+      F S P QI +++ LLYQ++  A  AGLG  +   PLN  L   +QK+ST  +  KD R+KI+ EIL GI+V+K YAWE +F +K+   R+ E++  L+        CV  W   P +I + TF  YVL    N +T  K F S+ LF +L  P+   PW +   M A+VS+KR+  +L  EEL+        +    A +   A++I DG FSW+     +E K T                   L+ +N  I +G+L+ ++G VG+GKSSL+SA+  EM ++ G V V    G    V+QE WIQ+ ++KENILF + Y+   Y D+I AC+L+ DL+ LP GD+TEIGE G+NLSGGQK RV LARAVYQN+ IYLLDDPL+AVDAHV  HL+++ I+  G+L+ KT IL TH   +L   D V+V+ SNG++   G   ++L       Q  ++     +             A  P+G   L +E A
Sbjct:  110 LLGGLHYAFGLQYFSLGILKLFCDCLGFSGPLLLHALVSFMENKTEPVIHGYYYAMGVLVSALLTALTNCHFTYWVHKISYKIRAAIITTVYHKTLAVSTTSLGKFSSGEVLNFMSTDTDRVVNFANSFHQFWSLPFQIAVSLYLLYQQVGLAFLAGLGFALLLIPLNRWLAIKIQKYSTEMMTQKDSRVKIMNEILYGIRVIKFYAWENNFKNKVNTFRNAELKS-LKGRKYLDAWCVYFWATTPIIISILTFTTYVLMG--NQLTAAKVFTSVALFQMLITPLNAFPWVINGMMEAWVSVKRLQAFLTLEELDPDNY----YIYIPAQSAGDAVQIVDGHFSWRYKPPQQEAKETKDVENLAEIETEVKSTVGLLSGLNLSIRKGQLIGVIGGVGSGKSSLLSALTAEMDKLTGQVFVAGLDGGFGLVAQEPWIQHATVKENILFGKPYDVDKYSDVINACALREDLQSLPAGDDTEIGENGVNLSGGQKARVGLARAVYQNKSIYLLDDPLAAVDAHVAAHLYKHCIT--GLLRHKTVILCTHHTKFLSGADHVIVM-SNGTVMHSGPPSEILSSERILRQISRDVSRERSLDGKEGGEDGEENADEPTGDGRLVEEEA 721

HSP 3 Score: 81.6481 bits (200), Expect = 2.495e-15
Identity = 56/203 (27.59%), Postives = 102/203 (50.25%), Query Frame = 3

Query: 2019 TLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISE 2588
             L N++ EI  G+ V IVG+ G+GKSSL   +   +    G+V + G              +A + Q+ ++ + S+++NI      +++     +E C L+  +  L GG + E+GERG N S GQ+Q V LARA+     I  +D+  ++VD    + +   +       +  T + + H ++ +   D VLV++  G+++E
Sbjct: 1127 ALRNVSLEIHAGEKVGIVGRTGSGKSSLFLVLFRMVEVAEGAVILDGVNIASLPLDKLRSRLAIIPQDPFLFSGSVRDNIDPWGKCSDRDLWITLERCHLQQPVSDL-GGLDAEVGERGRNFSAGQRQLVCLARAMLTRAKILCIDEATASVDMETDRFIQRTI---REAFRTSTVLTIAHRIDTVMDSDRVLVMN-KGTVTE 1324

HSP 4 Score: 53.1434 bits (126), Expect = 1.089e-6
Identity = 61/231 (26.41%), Postives = 96/231 (41.56%), Query Frame = 3

Query: 4188 VLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEA-TASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLA 4877
            +L  +NL    G+ IGV+G  G+GKSSL  AL   ++   G +           +  L     ++ Q+P I   T++EN+     +  D+    +    L+  +  L  G D E GE GVNLS                       GQK  + LARA+ +   + +LD+   A        L  H I    +  TVI+  H    +   D ++VM NG ++    P  +L+
Sbjct:  478 LLSGLNLSIRKGQLIGVIGGVGSGKSSLLSALTAEMDKLTGQVF----------VAGLDGGFGLVAQEPWIQHATVKENILFGKPYDVDKYSDVINACALREDLQSLPAGDDTEIGENGVNLS----------------------GGQKARVGLARAVYQNKSIYLLDDPLAAVDAHVAAHLYKHCITGLLRHKTVILCTHHTKFLSGADHVIVMSNGTVMHSGPPSEILS 676

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789])

HSP 1 Score: 982.245 bits (2538), Expect = 0.000e+0
Identity = 582/1546 (37.65%), Postives = 887/1546 (57.37%), Query Frame = 3

Query:  357 IDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHC-------FSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQD---------------ESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSL 4919
            +  ++++S  +L +T++LA L  +  R        I+ IFWL A +   +     I++  D  P  +           + L L+  +  C       FS   KD    PN  PCPE  AS LS++T+ W+   +   +++ + ++  + L  +D               E  K     EK+ Y   +  H   +          V  + E E  +     +S    L  +L   +    L++C +K + D  ++  P +L++L+ ++ +     W GYF A        + SL     F +  +  +R+R A+IG IYRK L +++  R   T GEIVNLMSVDA+R M+ + +     S PLQ+VLA+  L++ +  ++ AG+ +++   P+N ++    + +   ++K KD RIK++ E+LNGIKVLK+YAWE +F +K++ +R+ E++ +L+ +A  G V    W   PFL+ L+TF  YVL  + N++  EKAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    +        +A     +I I DG FSW + +  TL  +N  I  G LVA+VG VG+GKSSL+SA+LGEM ++ GSVSV+G++AYV Q+AWI N +LK NI+F Q   E +Y  ++EAC+L  DLE LP GDETEIGE+G+NLSGGQKQRVSLARAVY +R +YLLDDPLSAVDAHVG+H+F++VI   G+LKDKTRILVTHGL++LP+   VLV+  +G I+E GS++ L +    F +F                                LR  + NE    E T+ V  SP  P++       + +                       N + G   +++     +    S++ +  K TD +                +A++G VK + +   +K+ G+ L I ++  + +   L +F+N WL  +T+D  +     + L+ +                   +Y  +G+   + VC Y  S ++G I AS+ +H+ +L  VLRSPM FF+ TPSG ++NRF+K+++ +D +IPM +   +  LF V  S I+I+  TP  A+ I  L +LY+ +Q FY+ +SRQ +RL+S++ SP++ HF+ETL G ++IRAF EQ+ F + +   +D + K  +    + RWL++R+E +G  +V  A LF+++ R SL+  ++GLSISY+LQ+T  L WL+R  +++ETN VA+ER++EYS    EAEW  +    P D WP  G I   ++ LRYR  L L ++NIN+   GG+K+G+VGRTGAGKSSL L LFR++E A G+I ID ++I+ +GLH+LR R+TI+PQDPV+FSGTLR NLDPF S+ D++I+++LE +HL+S+VSGL + L +EC EGG NLS+                      GQ+QLLCLARALLRK+KVL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++V++ G++ E DSP NL+A     ++   D  L
Sbjct:  102 VAAVHLVSPTLLGLTMLLATLLVQYERMKGVQSSGIMLIFWLLALLCASVTFRSKILQAQD-QPEAVSGWRYTTFYVYYALLLLALVLSCLSDQMPLFSQAVKD----PN--PCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENK---------EVRAVEESEILIVKSPKKSREPSLLWALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQRYFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELK-VLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVER-----PAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVM-VDGEITEVGSYQQLKEKEGAFAEF--------------------------------LRMYAANEQ--SEETEPVPNSPTKPMENGVGPGFTGSQSA-------------------SNVSKGSVSEQN-----VEQKNSKNAEAGKTTDAD----------------KALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVVNGTQPNRLMRLG------------------VYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPD-WPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSL----------------------GQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAQKGAFYRMAKDSGL 1509

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: ENSORLT00000010371.2 (canalicular multispecific organic anion transporter 1 [Source:NCBI gene;Acc:101165337])

HSP 1 Score: 959.133 bits (2478), Expect = 0.000e+0
Identity = 580/1455 (39.86%), Postives = 877/1455 (60.27%), Query Frame = 3

Query:  678 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILE----------KIFY-DKIK----ISHNRKRYDLLQNSTASV--------AHLMEDEDKLTNPDNRS--------PGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYI-EHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIY-----AAFTGLQVFSNIWLKNFTED-SDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLNND 4928
            PE+ AS LS++T++W ++ +   +++ +  E  +DL  +D ++  +   +          ++ Y +K+K    I   R + +  +N  ++         A +MED+ K T    +         P   L  ++ + +   L+ +  FK + D   +  P LLK+++ + QN +   W GY  A+  L   +L SL     F    +L +++R A++  +Y+K L ++N+ R + T GE VNLMS DA+R  +   F     SCPLQI+++I+ L+ E+  ++ AGL ++V   P+NGLL    +K+    + +KD R+KI+ E+LNG+K+LK++AWE SF  ++ ++R  E++ + + +    V   ++   P L+ LA+F  +VL S  NI+T EKAF S++LFN+LRFP+ +LP  +   +   VS KR+ ++L GE+L    + H     D +F  D+A+ +R+GSFSW+++ +  L +++ +I  G+LVA+VG VG+GKSSL+SA+LGEMH   G ++++G++A+V Q+AWIQN +L++NILF   + EK ++++I+AC+L  DL+ L  G+ TEIGE+GINLSGGQKQRVSLARA Y   DIYLLDDPLSAVD+HVG+HLF+ VI  NG+LK KTRILVTHG+++LP VDEV+VL  +G ISE GS+  L      F +F+  Y  E NN+ K+   G                    D ED +E I +   T P  P++   S  +   +    S  S S+             NS V + ED                + ET         K   +L+E+E   +G VK++ Y   +++ G W + + V I       AF G     N+WL ++T D +D  N +          P W +  R      + ++  +G+    +V          S++AS+++H +LL ++LR PM FFDTTP GR++NRF+KDI  +D  IP +    L CL  V  ++ VI   TP+F I I+PLA++Y+ +Q FY+ TSRQ RRLDS++ SP+++HF ET+ G+++IRA++ Q  F   N+  ID++ K  +    S RWL++R+E LG L+VF + LF++I + SL + LVGL+ISY+L +T+ LNWL+R  +ELETN VA+ER+ EY++I +EA+W  +  P + WP+ G + F DY +RYR GL LVL  I  +    +KIG+VGRTGAGKSSL   LFR++EAA G I+ID ++ISTIGLHDLR RLTI+PQDPV+FSGTLR NLDPF    D+E++++LE +HL+ +V+GL EGL +E  EGG NLSV                      GQ+QLLCLARALLRKS++LILDEATA+VD+ETD L+ +TIR+ F   TV+ IAHR+++I+D+  ++V++ G+IVE DSP NLL      F    D  +  +
Sbjct:   62 PEIGASFLSRITFNWFNSMVVTGYKRPLVQEDMWDLNEKDGTSYLSQRFQHHMDFELAAARVRYQNKLKKHLVIHKGRSQAEASENGISNGLGKGVSRDALMMEDKGKSTEKKKKKKEKKEEDYPNSWLLSTMYKTFKWLLIESAFFKLLQDLLAFVSPQLLKLMISFTQNPNSFVWEGYMYAVLLLLVAILQSLFLQQYFQRCFVLGMKVRTAVMAAVYKKALVVSNDTRKESTVGETVNLMSADAQRFNDVTNFIHLLWSCPLQIIVSIVFLWLELGPSVLAGLLVMVLMVPINGLLATQARKYQVQNMNFKDKRMKIMNELLNGVKILKLFAWEPSFQSQVESIRGEELKVMKKFAYLSSVSTFIFSCAPALVSLASFAVFVLVSPDNILTAEKAFTSISLFNILRFPLAMLPMLIASIVQTGVSKKRLEKFLGGEDLEPDIVRH-----DPSF--DSAVSVRNGSFSWERDAEPLLKDVSLDIEPGRLVAVVGAVGSGKSSLMSALLGEMHCTEGFINIKGSLAFVPQQAWIQNATLRDNILFGSPHEEKRFQEVIQACALGPDLKLLAAGELTEIGEKGINLSGGQKQRVSLARAAYSQADIYLLDDPLSAVDSHVGKHLFDKVIGPNGVLKHKTRILVTHGVSFLPYVDEVVVL-VDGKISEIGSYNSLRASKGAFSEFLDTYAKEQNNQTKSDKDG------------------CQDTED-LEIIPEREDTQPDSPLEDTVSFTLKRENSIRRSQRSSSVRVR---------KNSTVKKSED----------------ANET---------KAGQRLIEKETMETGQVKFSVYLQYLRALG-WGYTSMVFIIYFIQNVAFIG----QNLWLSDWTNDAADYYNQTY---------PNWKRDTR------VGVFGALGIAQGFLVFLGTLLLANASVSASRILHSRLLNNILRVPMVFFDTTPVGRVVNRFAKDIFTIDEAIPQSFRSWLLCLLGVLGTLFVICLATPFFTIIILPLAVIYFFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYRHQDRFLKHNEVTIDENLKSVYPWIVSNRWLAIRLEFLGNLVVFFSALFAVISKDSLDSGLVGLAISYALNVTQTLNWLVRMSSELETNIVAVERVSEYTEIENEAKWITDCRPPERWPDEGKLQFIDYKVRYRPGLDLVLHGITCNIASSEKIGIVGRTGAGKSSLTNCLFRIIEAAEGRILIDDVDISTIGLHDLRGRLTIIPQDPVLFSGTLRMNLDPFDKFSDEELWKALELSHLKDYVAGLQEGLQHEVAEGGENLSV----------------------GQRQLLCLARALLRKSRILILDEATAAVDLETDNLIQNTIRKEFAHCTVLTIAHRLHSIMDSSRVMVLDAGKIVEFDSPSNLLENRGYFFSMAKDAGITQE 1413

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789])

HSP 1 Score: 958.748 bits (2477), Expect = 0.000e+0
Identity = 572/1509 (37.91%), Postives = 868/1509 (57.52%), Query Frame = 3

Query:  357 IDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHC-------FSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQD---------------ESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILD 4808
            +  ++++S  +L +T++LA L  +  R        I+ IFWL A +   +     I++  D  P  +           + L L+  +  C       FS   KD    PN  PCPE  AS LS++T+ W+   +   +++ + ++  + L  +D               E  K     EK+ Y   +  H   +          V  + E E  +     +S    L  +L   +    L++C +K + D  ++  P +L++L+ ++ +     W GYF A        + SL     F +  +  +R+R A+IG IYRK L +++  R   T GEIVNLMSVDA+R M+ + +     S PLQ+VLA+  L++ +  ++ AG+ +++   P+N ++    + +   ++K KD RIK++ E+LNGIKVLK+YAWE +F +K++ +R+ E++ +L+ +A  G V    W   PFL+ L+TF  YVL  + N++  EKAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    +  R     S +    +I I DG FSW + +  TL  +N  I  G LVA+VG VG+GKSSL+SA+LGEM ++ GSVSV+G++AYV Q+AWI N +LK NI+F Q   E +Y  ++EAC+L  DLE LP GDETEIGE+G+NLSGGQKQRVSLARAVY +R +YLLDDPLSAVDAHVG+H+F++VI   G+LKDKTRILVTHGL++LP+   VLV+  +G I+E GS++ L +    F +F                                LR  + NE    E T+ V  SP  P++       + +                       N + G   +++     +    S++ +  K TD +                +A++G VK + +   +K+ G+ L I ++  + +   L +F+N WL  +T+D  +     + L+ +                   +Y  +G+   + VC Y  S ++G I AS+ +H+ +L  VLRSPM FF+ TPSG ++NRF+K+++ +D +IPM +   +  LF V  S I+I+  TP  A+ I  L +LY+ +Q FY+ +SRQ +RL+S++ SP++ HF+ETL G ++IRAF EQ+ F + +   +D + K  +    + RWL++R+E +G  +V  A LF+++ R SL+  ++GLSISY+LQ+T  L WL+R  +++ETN VA+ER++EYS    EAEW  +    P D WP  G I   ++ LRYR  L L ++NIN+   GG+K+G+VGRTGAGKSSL L LFR++E A G+I ID ++I+ +GLH+LR R+TI+PQDPV+FSGTLR NLDPF S+ D++I+++LE +HL+S+VSGL + L +EC EGG NLS+                      GQ+QLLCLARALLRK+KVL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D
Sbjct:  102 VAAVHLVSPTLLGLTMLLATLLVQYERMKGVQSSGIMLIFWLLALLCASVTFRSKILQAQD-QPEAVSGWRYTTFYVYYALLLLALVLSCLSDQMPLFSQAVKD----PN--PCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENK---------EVRAVEESEILIVKSPKKSREPSLLWALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQRYFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELK-VLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSV-ERPAAGGSPY----SISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVM-VDGEITEVGSYQQLKEKEGAFAEF--------------------------------LRMYAANEQ--SEETEPVPNSPTKPMENGVGPGFTGSQSA-------------------SNVSKGSVSEQN-----VEQKNSKNAEAGKTTDAD----------------KALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVVNGTQPNRLMRLG------------------VYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPD-WPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSL----------------------GQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1472

HSP 2 Score: 76.2554 bits (186), Expect = 3.170e-13
Identity = 73/295 (24.75%), Postives = 125/295 (42.37%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNL 4871
            LN L    + +    V+L+R+R +       E  +    +   P +  I+ +D    +       LK +N+    G  + VVG  G+GKSSL  AL   ++   GS+              ++  +  +PQ   I + TL+ N+      K+    + +E   L   +  L  G + E GE GVNLS                       GQKQ + LARA+     V +LD+  ++VD    + +  H I  +   +  T I++ H ++ +    +++VM +GEI E+ S + L
Sbjct:  595 LNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVERPAAGGSPYS--ISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSV-------------SVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLS----------------------GGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQL 852

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789])

HSP 1 Score: 957.977 bits (2475), Expect = 0.000e+0
Identity = 572/1509 (37.91%), Postives = 868/1509 (57.52%), Query Frame = 3

Query:  357 IDGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHC-------FSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQD---------------ESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVL-WEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEW--DLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILD 4808
            +  ++++S  +L +T++LA L  +  R        I+ IFWL A +   +     I++  D  P  +           + L L+  +  C       FS   KD    PN  PCPE  AS LS++T+ W+   +   +++ + ++  + L  +D               E  K     EK+ Y   +  H   +          V  + E E  +     +S    L  +L   +    L++C +K + D  ++  P +L++L+ ++ +     W GYF A        + SL     F +  +  +R+R A+IG IYRK L +++  R   T GEIVNLMSVDA+R M+ + +     S PLQ+VLA+  L++ +  ++ AG+ +++   P+N ++    + +   ++K KD RIK++ E+LNGIKVLK+YAWE +F +K++ +R+ E++ +L+ +A  G V    W   PFL+ L+TF  YVL  + N++  EKAFVSL LFN+LRFP+ +LP  ++  + A VSLKR+  +L  EEL    +  R     S +    +I I DG FSW + +  TL  +N  I  G LVA+VG VG+GKSSL+SA+LGEM ++ GSVSV+G++AYV Q+AWI N +LK NI+F Q   E +Y  ++EAC+L  DLE LP GDETEIGE+G+NLSGGQKQRVSLARAVY +R +YLLDDPLSAVDAHVG+H+F++VI   G+LKDKTRILVTHGL++LP+   VLV+  +G I+E GS++ L +    F +F                                LR  + NE    E T+ V  SP  P++       + +                       N + G   +++     +    S++ +  K TD +                +A++G VK + +   +K+ G+ L I ++  + +   L +F+N WL  +T+D  +     + L+ +                   +Y  +G+   + VC Y  S ++G I AS+ +H+ +L  VLRSPM FF+ TPSG ++NRF+K+++ +D +IPM +   +  LF V  S I+I+  TP  A+ I  L +LY+ +Q FY+ +SRQ +RL+S++ SP++ HF+ETL G ++IRAF EQ+ F + +   +D + K  +    + RWL++R+E +G  +V  A LF+++ R SL+  ++GLSISY+LQ+T  L WL+R  +++ETN VA+ER++EYS    EAEW  +    P D WP  G I   ++ LRYR  L L ++NIN+   GG+K+G+VGRTGAGKSSL L LFR++E A G+I ID ++I+ +GLH+LR R+TI+PQDPV+FSGTLR NLDPF S+ D++I+++LE +HL+S+VSGL + L +EC EGG NLS+                      GQ+QLLCLARALLRK+KVL+LDEATA++D+ETD L+  TIR  F+  TV+ IAHR+NTI+D
Sbjct:  140 VAAVHLVSPTLLGLTMLLATLLVQYERMKGVQSSGIMLIFWLLALLCASVTFRSKILQAQD-QPEAVSGWRYTTFYVYYALLLLALVLSCLSDQMPLFSQAVKD----PN--PCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENK---------EVRAVEESEILIVKSPKKSREPSLLWALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQRYFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELK-VLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSV-ERPAAGGSPY----SISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVM-VDGEITEVGSYQQLKEKEGAFAEF--------------------------------LRMYAANEQ--SEETEPVPNSPTKPMENGVGPGFTGSQSA-------------------SNVSKGSVSEQN-----VEQKNSKNAEAGKTTDAD----------------KALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVVNGTQPNRLMRLG------------------VYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPD-WPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSL----------------------GQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1510

HSP 2 Score: 76.2554 bits (186), Expect = 3.300e-13
Identity = 73/295 (24.75%), Postives = 125/295 (42.37%), Query Frame = 3

Query: 3996 LNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVM-HTI--REYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNL 4871
            LN L    + +    V+L+R+R +       E  +    +   P +  I+ +D    +       LK +N+    G  + VVG  G+GKSSL  AL   ++   GS+              ++  +  +PQ   I + TL+ N+      K+    + +E   L   +  L  G + E GE GVNLS                       GQKQ + LARA+     V +LD+  ++VD    + +  H I  +   +  T I++ H ++ +    +++VM +GEI E+ S + L
Sbjct:  633 LNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVERPAAGGSPYS--ISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSV-------------SVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLS----------------------GGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQL 890

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BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc6a (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101158001])

HSP 1 Score: 957.207 bits (2473), Expect = 0.000e+0
Identity = 557/1522 (36.60%), Postives = 877/1522 (57.62%), Query Frame = 3

Query:  366 LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIF-YDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNP--DNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDL-NNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSL 4919
            ++++S +I  +T++LA+   ++ R         LF+FW+ + +  L+ L   I   +D    +     +   +         FL  CF+           K PCP   AS LSK+ + W    + K +R  +     + LR +D S K  + L++ +  +  K+    K  +    S   +   + D+ +L       +S G+ L  +LAR +G   L        HD  ++A+P +L +LL +I++     W GYF A        L SL  +   +    + +R++ A++G++YRK+L +N+  R   T GEIVNL+S D +++M+++++       P++I L +  L+Q +  +  AG+  ++  FPLNG +     K   I++K+ D R++++ EILNGIK+LK YAWEK+FL+++   R+ E++ + +    + +    +    FLI  A F  YV+  E N++  +K FVS+ L N+L+ P+  LP+ ++ +M A VSL+R+G+YL  EEL +  ++    + D     D  IE  +G+FSW KE    L  I+  + RG LVA+VG VG+GKSSL+SA+LGE  + +G V+V+G++AYV Q+AWIQN ++++NILF ++  + +Y+ ++EAC+L  DL+ LP GD TEIGE+G+NLSGGQKQRVSLARAVY+  D+YLLDDPLSAVDAHVGQH+F+ VI   G+LKD+TRILVTHG+++LP+ D +LVL  +G I+E GS+++LL     F  F+  +     +            ESA+ +A       S   +    + DF+      P  R+ S                        +   + +N+ + ++ +P S               E DQ+    + + + +L E ++A +G VK   Y    K+ GL + I  V +YA   G  +  + WL  + +D  + N +Q                       + ++  +G    + +     + ++  I AS+ +H  LL +VLRSPM FF++TPSG ++NRF K+I+ +D ++P  +   LS +F +    I+++  TP  A+ I+PLA LY  +Q FY+ TS Q RRL++++ SP++ HF ET+QG ++IRAF EQ  F       +D +    F +  + RWL++ +E +G  +V AA + S+IG+ +++  +VGL++S+SLQ+T  L+W++R +T++E N V++ER+ EY+  P EA W+   +A   +WP +G I F+DY L+YR+GL L LK I L     +KIG+VGRTGAGKSSL L +FR++EAA G I ID +NI+ IGLHDLR R+TI+PQDPV+FSG+LR NLDPF  + D+EI+ SLE AHL+ +VS L + L++EC EGG NLS+                      GQ+QL+CLARALLRK+K+L+LDEATA+VD+ETD L+  TIR  F+  TV+ IAHR+NTI+D   ++VM+ G I E+DSP NL++     ++   +  L
Sbjct:  103 VFLLSPIIRSMTVILALCIIQLERIRGCRSSIFLFLFWVLSVVCSLVPLRAKIQLAVDEGIASDIVRYLAFFSYFTIQMAQLFLC-CFADQPPQGKPNLEKNPCPVKDASFLSKILFWWFTGLVVKGYRTPLEATDLWTLREEDTSHKIISDLQQEWGAECAKLQKQEKSLE----SAPVLGSRLPDQAQLLRKLQKEQSSGFFLLRTLARKFGPYFLTGTLCIIFHDAFMFAIPQVLSLLLGFIRDPEAPQWKGYFYATLMFLLSCLQSLFNHQYMYTCFTVGMRVKTAVMGLVYRKSLVINSAARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEIGLCLFFLWQHLGPSALAGIATVILIFPLNGFIAKKRSKLQEIQMKFMDGRVRLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKALKKSQVLYSISIASFNSSSFLIAFAMFGVYVMLDERNVLDAQKVFVSMALINILKTPLSQLPFAISTTMQALVSLRRLGKYLCSEELKVDGVSKALSSSDGE---DVVIE--NGTFSWSKEGPPCLKRISVRVPRGSLVAVVGHVGSGKSSLLSAMLGETEKRSGQVTVKGSVAYVPQQAWIQNATVQDNILFGREKLKTWYQRVLEACALLPDLDILPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKADLYLLDDPLSAVDAHVGQHIFDKVIGPKGVLKDRTRILVTHGMSFLPQADLILVL-IDGEITESGSYQELLSHHGAFADFIHTFASTEKK------------ESAIQRAG------SRRSNARLSMVDFM------PFSRDLSQE---------------------QLIGGDTTNTNL-QNMEPVS---------------ENDQDQ---VPEDLGKLTEADKAHTGRVKLDMYKKYFKTIGLAIIIPIVFLYAFQQGASLAYSYWLSMWADDP-VVNGTQ-----------------TDRDLKLAVFGALGFVQGIAIFGTTVAISICGIIASRQLHMDLLVNVLRSPMAFFESTPSGNLLNRFVKEIDAIDCMVPEGLKMMLSYVFKLVEVCIIVLIATPIAAVIILPLAFLYAFVQSFYVATSCQLRRLEAVSRSPIYTHFNETVQGASVIRAFGEQSRFIMQANERVDFNQTSYFPRFVATRWLAVNLEFVGNGVVLAAAVLSVIGKSTVSPGIVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVNEYADTPKEASWNTEGSALPLAWPQSGTIEFQDYGLQYRKGLELALKGITLQIQKREKIGIVGRTGAGKSSLALGIFRILEAAKGRIFIDGVNIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDIYTDEEIWSSLELAHLKDFVSNLPDKLNHECSEGGENLSL----------------------GQRQLVCLARALLRKTKILVLDEATAAVDLETDTLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGYISEMDSPANLISQRGQFYRMCREAGL 1509

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BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000273.1 (SMESG000000273.1)

HSP 1 Score: 2447.16 bits (6341), Expect = 0.000e+0
Identity = 1253/1261 (99.37%), Postives = 1256/1261 (99.60%), Query Frame = 3

Query:  606 MNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQ 4388
            MNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHR+FTD+SAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEK YEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNN   NPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNASDRLSSSISKSIDGFSRHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKD+ENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFAIAIIPLAILYYLIQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDKSSKFKFIQQSSVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSI IDKINISTIGLHDLRKRLTILPQ
Sbjct:    1 MNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHREFTDNSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKVYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNN---NPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNASDRLSSSISKSIDGFSRHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDMENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFAIAIIPLAILYYLIQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDKSSKFKFIQQSSVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSITIDKINISTIGLHDLRKRLTILPQ 1258

HSP 2 Score: 77.0258 bits (188), Expect = 1.258e-13
Identity = 64/253 (25.30%), Postives = 117/253 (46.25%), Query Frame = 3

Query: 4131 NGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSL-ETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVME-NGEIVEIDSPKNLL 4874
            +  I  +D    +++   L L NIN     GK + +VG+ G GKSSL  A+   +    GS+              ++  +  + Q+  I + +L+EN+  F+   ++++++ + E   L+S +  L  G + E GE G+NLS                       GQKQ + LARA+ +   + +LD+  ++VD    + +   +       +  T I++ H +N +   D ++V++ NG I E  S K+LL
Sbjct:  453 DAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSV-------------SVQGTIAYVSQEAWIQNKSLKENI-LFTQDYNEKVYEDIIEACSLKSDLEQLPGGDETEIGERGINLS----------------------GGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLL 669

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BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000283.1 (SMESG000000283.1)

HSP 1 Score: 1568.52 bits (4060), Expect = 0.000e+0
Identity = 854/1536 (55.60%), Postives = 1092/1536 (71.09%), Query Frame = 3

Query:  345 SNSLI--DGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYN----IRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNS----GVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQSLN 4922
            +NSL   +GLY++SY  L   L L ++Q EIRRR  HPVC ILFIFW T +I YL+R Y  I+     S  N    I+         +  LF+ +F  +C     K   ++  + PCPE YAS +SKLT+SW D+YIYKW ++EMT+E SF+LR  DES K  N++EK F  KI+    + +     N + S  +L+ D D+       + GW+LF  L++V+  +L++A   K + D  +   P+LLKILL Y+ + +   WI Y +A  FL  G+LSS+ EN  +F+TS LS+RIRA +IGMIY KTLRL+ E RNK+T+GEIVNLMSVDAERIM +I F+WF  SCP QI++A +LLYQEM+YAIFAG GL + F PLNGLLM     FS +ELKWKD RIKI +EIL GIKV+KMY WE+SF+ KIT LR+ E++YILR    +G+V ++WEILP LI++   L +V  + +N IT EKAFVSL+LFNL+RF ++++P+GLT+++NAFVSLKRI +YL+ EE+      +     +     D AIEI+ G+FSWK+ DK+ LNNIN  I +GKL+A+VGK+G+GKSSLISAILGEM  I+G V ++G IAYVSQE WIQN++LK NILFT+DYNE FY+ ++ +C L  DLEQLP GDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVD+HV   LFEN+ISNNGIL  KTR+L+THGLNWLPKVDE++VLD++G IS+RGSFKDLL++  +F QF++   +H N  KN   G + S ES +   + +     +N+ ++ EI D   +   +  + +  +                      H  +    +S     V +D D +    +    +  + S+E + N   LI +   QL++EEQA  G VK   Y + +KSRGL LF+ TV IY++F  LQVFS IW++ FTED  IQN S  IL N S     S  IRE+T++YM+ Y+ I + M  VV  +W  F +G+ N+ K IH KLL S+LR PMEFFDTTP GRI+NR S D++ +D  +P+N+S+S SC F+V +SIIVIIYVTPWFAI IIPL I YY IQ  Y+PTSRQSRRLD+IA SPVFN FTET+QG+++IRA K + YFQ L+  +IDK+S+F+FIQ SS+RWL  RI+I+G L+VF AV+ SI     LTA LVGLSISYSLQ+TE LNWLLRQYTE+E N VALERIREYS +PSEAEW+    P ++WPN GNI F + DL+YRE L  VLKNINL  +GG K+G+VGRTGAGKSSL LALFRL+EA+ G I+ID ++ISTIGLHDLRKRLTILPQDPVIFSGTLRENLDPF+ H D++++Q LETAHLQ WVS L+EG++YECGEGGVNLS                      AGQ+QLLCLARALLRKSK+LILDEATASVD ETD+LVM T++EYF+ STVIIIAHRINTILDTD IVV+++GE+VEI SPK+LL  +DGIFKSLHDQ++N
Sbjct:   16 ANSLAVSEGLYLLSYGCLSTALFLVIIQTEIRRRICHPVCPILFIFWFTGSIAYLIRFYSEIVGYSKNSSSNDLIVIQISGALFLLFLLNLFIESFPRYC-----KLNSMINKENPCPEEYASTISKLTFSWFDSYIYKWRKEEMTEENSFELRSNDESKKYINLVEKSFLKKIEFCKEKSKQ---INKSNSSKNLLTDNDEEFREKKHNSGWILFSCLSKVFLFQLVVAWVLKLIGDTLLLFTPYLLKILLRYVNSENKTTWISYGIAFTFLANGILSSIMENYSYFMTSYLSVRIRAVIIGMIYSKTLRLSREARNKYTTGEIVNLMSVDAERIMVFIDFSWFIFSCPFQIIIATVLLYQEMNYAIFAGFGLFLVFLPLNGLLMKYAHGFSDVELKWKDERIKIFSEILTGIKVIKMYGWEQSFISKITGLRNLEVKYILRSQIIWGIVYIIWEILPSLIIMVMILSFVFMNRFNFITAEKAFVSLSLFNLIRFSLIIVPYGLTETVNAFVSLKRIAEYLMVEEMEPIGFTYLQNLYEEQLENDPAIEIQGGTFSWKRSDKVILNNINLSIAKGKLIAVVGKIGSGKSSLISAILGEMVTISGDVKIKGRIAYVSQEPWIQNRTLKNNILFTEDYNETFYKKVVVSCCLTQDLEQLPMGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDSHVAHSLFENIISNNGILGGKTRVLITHGLNWLPKVDEIVVLDNSGHISDRGSFKDLLENSLKFKQFIK---DHMNPGKNSVNGANFSHESII--EEKVKHHSPENDQLLYEIPD---SGSGIETEFDLDY----------------------HGPFISKESSPLQFTVVDDADIE----LHNKIKDLEFSEENNHN---LISRSNGQLIDEEQAFVGNVKAKEYFVYVKSRGLLLFLLTVLIYSSFVALQVFSFIWIEKFTEDKVIQNLSNLILKNASYVIDQSNQIRERTEFYMIRYSFICIAMIGVVSLFWVCFAMGTYNSMKYIHGKLLYSILRCPMEFFDTTPVGRILNRLSHDMDLMDRKMPVNLSESFSCFFVVLSSIIVIIYVTPWFAIVIIPLFIFYYFIQFLYMPTSRQSRRLDAIATSPVFNIFTETIQGISIIRACKVESYFQELSYEIIDKNSRFRFIQVSSMRWLCFRIDIIGSLVVFFAVILSITNVSYLTAGLVGLSISYSLQVTEALNWLLRQYTEVEMNMVALERIREYSMVPSEAEWNSLMPPPENWPNIGNIKFIELDLKYRESLSFVLKNINLDLNGGYKVGIVGRTGAGKSSLTLALFRLMEASNGKIVIDGLDISTIGLHDLRKRLTILPQDPVIFSGTLRENLDPFNVHTDEDLYQCLETAHLQDWVSSLNEGMNYECGEGGVNLS----------------------AGQRQLLCLARALLRKSKILILDEATASVDFETDKLVMTTVKEYFRQSTVIIIAHRINTILDTDKIVVLDSGEVVEIGSPKDLLEQADGIFKSLHDQNIN 1484

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BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000283.1 (SMESG000000283.1)

HSP 1 Score: 1213.36 bits (3138), Expect = 0.000e+0
Identity = 660/1252 (52.72%), Postives = 862/1252 (68.85%), Query Frame = 3

Query:  345 SNSLI--DGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYN----IRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYWIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNS----GVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYS 4070
            +NSL   +GLY++SY  L   L L ++Q EIRRR  HPVC ILFIFW T +I YL+R Y  I+     S  N    I+         +  LF+ +F  +C     K   ++  + PCPE YAS +SKLT+SW D+YIYKW ++EMT+E SF+LR  DES K  N++EK F  KI+    + +     N + S  +L+ D D+       + GW+LF  L++V+  +L++A   K + D  +   P+LLKILL Y+ + +   WI Y +A  FL  G+LSS+ EN  +F+TS LS+RIRA +IGMIY KTLRL+ E RNK+T+GEIVNLMSVDAERIM +I F+WF  SCP QI++A +LLYQEM+YAIFAG GL + F PLNGLLM     FS +ELKWKD RIKI +EIL GIKV+KMY WE+SF+ KIT LR+ E++YILR    +G+V ++WEILP LI++   L +V  + +N IT EKAFVSL+LFNL+RF ++++P+GLT+++NAFVSLKRI +YL+ EE+      +     +     D AIEI+ G+FSWK+ DK+ LNNIN  I +GKL+A+VGK+G+GKSSLISAILGEM  I+G V ++G IAYVSQE WIQN++LK NILFT+DYNE FY+ ++ +C L  DLEQLP GDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVD+HV   LFEN+ISNNGIL  KTR+L+THGLNWLPKVDE++VLD++G IS+RGSFKDLL++  +F QF++   +H N  KN   G + S ES +   + +     +N+ ++ EI D   +   +  + +  +                      H  +    +S     V +D D +    +    +  + S+E + N   LI +   QL++EEQA  G VK   Y + +KSRGL LF+ TV IY++F  LQVFS IW++ FTED  IQN S  IL N S     S  IRE+T++YM+ Y+ I + M  VV  +W  F +G+ N+ K IH KLL S+LR PMEFFDTTP GRI+NR S D++ +D  +P+N+S+S SC F+V +SIIVIIYVTPWFAI IIPL I YY IQ  Y+PTSRQSRRLD+IA SPVFN FTET+QG+++IRA K + YFQ L+  +IDK+S+F+FIQ SS+RWL  RI+I+G L+VF AV+ SI     LTA LVGLSISYSLQ+TE LNWLLRQYTE+E N VALERIREYS
Sbjct:   16 ANSLAVSEGLYLLSYGCLSTALFLVIIQTEIRRRICHPVCPILFIFWFTGSIAYLIRFYSEIVGYSKNSSSNDLIVIQISGALFLLFLLNLFIESFPRYC-----KLNSMINKENPCPEEYASTISKLTFSWFDSYIYKWRKEEMTEENSFELRSNDESKKYINLVEKSFLKKIEFCKEKSKQ---INKSNSSKNLLTDNDEEFREKKHNSGWILFSCLSKVFLFQLVVAWVLKLIGDTLLLFTPYLLKILLRYVNSENKTTWISYGIAFTFLANGILSSIMENYSYFMTSYLSVRIRAVIIGMIYSKTLRLSREARNKYTTGEIVNLMSVDAERIMVFIDFSWFIFSCPFQIIIATVLLYQEMNYAIFAGFGLFLVFLPLNGLLMKYAHGFSDVELKWKDERIKIFSEILTGIKVIKMYGWEQSFISKITGLRNLEVKYILRSQIIWGIVYIIWEILPSLIIMVMILSFVFMNRFNFITAEKAFVSLSLFNLIRFSLIIVPYGLTETVNAFVSLKRIAEYLMVEEMEPIGFTYLQNLYEEQLENDPAIEIQGGTFSWKRSDKVILNNINLSIAKGKLIAVVGKIGSGKSSLISAILGEMVTISGDVKIKGRIAYVSQEPWIQNRTLKNNILFTEDYNETFYKKVVVSCCLTQDLEQLPMGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDSHVAHSLFENIISNNGILGGKTRVLITHGLNWLPKVDEIVVLDNSGHISDRGSFKDLLENSLKFKQFIK---DHMNPGKNSVNGANFSHESII--EEKVKHHSPENDQLLYEIPD---SGSGIETEFDLDY----------------------HGPFISKESSPLQFTVVDDADIE----LHNKIKDLEFSEENNHN---LISRSNGQLIDEEQAFVGNVKAKEYFVYVKSRGLLLFLLTVLIYSSFVALQVFSFIWIEKFTEDKVIQNLSNLILKNASYVIDQSNQIRERTEFYMIRYSFICIAMIGVVSLFWVCFAMGTYNSMKYIHGKLLYSILRCPMEFFDTTPVGRILNRLSHDMDLMDRKMPVNLSESFSCFFVVLSSIIVIIYVTPWFAIVIIPLFIFYYFIQFLYMPTSRQSRRLDAIATSPVFNIFTETIQGISIIRACKVESYFQELSYEIIDKNSRFRFIQVSSMRWLCFRIDIIGSLVVFFAVILSITNVSYLTAGLVGLSISYSLQVTEALNWLLRQYTEVEMNMVALERIREYS 1222

HSP 2 Score: 83.5741 bits (205), Expect = 1.404e-15
Identity = 105/401 (26.18%), Postives = 175/401 (43.64%), Query Frame = 3

Query: 3729 FTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVL-FSIIGRFS-LTA--SLVGLS----ISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWD---LNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQS-LETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTDIIVVMEN-GEIVEIDSPKNLLAMS 4883
            F+E L G+ +I+ +  +Q F +    L +   K+    Q     + +  EIL  L++   +L F  + RF+ +TA  + V LS    I +SL I  +        TE     V+L+RI EY  +          L N   +   N+  I  +     ++    ++L NINL    GK I VVG+ G+GKSSL  A+   +    G +              ++ R+  + Q+P I + TL+ N+  F+   ++  ++  + +  L   +  L  G + E GE G+NLS                       GQKQ + LARA+ +   + +LD+  ++VD      +   I          T ++I H +N +   D IVV++N G I +  S K+LL  S
Sbjct:  414 FSEILTGIKVIKMYGWEQSFISKITGLRNLEVKYILRSQIIWGIVYIIWEILPSLIIMVMILSFVFMNRFNFITAEKAFVSLSLFNLIRFSLIIVPY------GLTETVNAFVSLKRIAEYLMVEEMEPIGFTYLQNLYEEQLENDPAIEIQGGTFSWKRSDKVILNNINLSIAKGKLIAVVGKIGSGKSSLISAILGEMVTISGDV-------------KIKGRIAYVSQEPWIQNRTLKNNI-LFTEDYNETFYKKVVVSCCLTQDLEQLPMGDETEIGERGINLS----------------------GGQKQRVSLARAVYQNRDIYLLDDPLSAVDSHVAHSLFENIISNNGILGGKTRVLITHGLNWLPKVDEIVVLDNSGHISDRGSFKDLLENS 772

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074229.1 (SMESG000074229.1)

HSP 1 Score: 1125.92 bits (2911), Expect = 0.000e+0
Identity = 688/1642 (41.90%), Postives = 975/1642 (59.38%), Query Frame = 3

Query:   78 ICQDGFWNSTSFSNVKYPIFTECFQYVILLI-PSGXXXXXXXXXXXXKKYKSHPIIKVPCTFYYGLKLSSQAXXXXXXXXXXXXXXXXTKSNSLIDGLY--------IMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPN--KIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNR-KRYDLLQNSTASVAHLMEDEDKLTNPDNRSP------GWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNY-WIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQ--------------NRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGG--QHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFK 4898
            +CQD FW+++ F +  YPIFT CFQY +L+I PS  FI+   +       K H  +K+     + L+ S + ++ IL  + +        +  LID LY         +S  +L  +L       E+RRR    +  ILF+FW     GY  R Y + I LL  S  N R  L   S+    +F+++ +   F  F       PN  +   PE+ ASI S+LTY W+D++IY W++ +MTD+TSFDL   ++S+ N+ I  + F       HN  +R D+ + ++ S     EDE+ L N + +        G VL  S+   +   +L+AC  + V D  I  +P +LK+LL Y + +  NY W G   A  FL  G++ S+ EN CF +T+ +SIR+R ++IGMI RKTLRL+ E +  +++G+I+N+  VD E+IMNWI+++W  LSCP QI+L ++LLY E+  +IF G+ +IV   P+   +M L +K+S  EL WKD R+ ILTEILNGIKV+KMY WEKSF +KI ++R  E++     S  + ++ V+++++PFL+M +TF  Y+    ++II+ EK F+++ LFN ++ PM++LPWG+T ++ A VS  RIG++L+  E+          T  S    DA+IEI+ G FSW K     L NI   + + KL+A+VG+VG GKSSL+SAILGEM+ +NG+V  +G IAYV QEAWIQN +L+ NIL T+ +N+ FY  +++AC L+ D+E LP  D+TEIGERG+NLSGGQKQRVSLARAVYQ              + DIYLLDDPLSAVD +VGQ LF  +ISN G+LK KTR+LVTHGL                                +++ FV E    N++ +    G  +HL D     + K+ L + SD  D  +      L  P+ P +R                                            K  R+ T GSQ      + ++N +   +K  + +  EE+ MSG V   +     K+ G+++F +++     F  LQ F N+WL    +   + N S     N S         R   K+Y+  Y IIGL   L V  +W  FT G + ASK IH  LL +VLRS ++FF+ TPSGRI+NRFSKD+  +DH + +NI+D ++   ++  S++VI  VTPWF I  IP+ I Y L+Q+FYI +SRQ+RRLDS A+S V  H  ET  G ++IR+ + +  F+++    IDKS+KFK IQ  S+RWL LR++ILG L+VF +V+F+++ RFSL+ASLVGLSISY+LQ+T  LNWL RQ  E ETN V++ERIR+Y+ IP E+  + NN  S++W +NGNI  +++ L+Y   LP VLKNI ++ +GG+KIGVVGRTGAGKSSL LALFRLVE   G I ID +NI++IGLH LR++LTILPQDPVIFSGTL+ NLDPF  + DD++ +SLE + +  WV+ L +GL Y+CG  G NLS                       GQKQL+CLAR +L+ SK++ILDEATASVD +TDR V   I   F+ STVIIIAHRI TI+  D I+  ENG +VE  SP+ LL  ++G F+
Sbjct:    7 LCQDSFWSNSHFQSPNYPIFTNCFQYTLLIIGPSIFFIMFSILLLESLFNKKH--LKIITFHSFDLRHSIKIILPILGGILVF-------AEMLIDNLYTTNKDSMLFISCGLLSASLFSVSFATELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPN-RIILFLFSSFAILIFIVSIILDTFLRFP------PNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYF-------HNYGEREDIFRRASKS-----EDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRHEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSP---DASIEIQSGRFSWTKIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGTVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGL--------------------------------KWLPFVDEICVINDQGQISERGTYEHLMDFGT--EFKSFLNESSDKVDKNQN----NLIQPSAPNKR--------------------------------------------KRSRLSTSGSQGF----DGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNST---FNQS---------RNSAKFYINCYGIIGLGQLLAVILFWGGFTFGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFSKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVVNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITMNINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNLLKDGLYYDCGYMGANLS----------------------TGQKQLVCLARTVLKNSKIIILDEATASVDEDTDRRVFDAITSQFRNSTVIIIAHRIKTIIGCDKILYFENGSVVEFGSPQELLLKANGKFR 1497

HSP 2 Score: 90.5077 bits (223), Expect = 1.018e-17
Identity = 112/498 (22.49%), Postives = 217/498 (43.57%), Query Frame = 3

Query: 1206 SIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVD---AERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAF----VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQF 2639
            S +I + L+  + R TL+  N       SG I+N  S D    +  +N  I     ++  + ++ +++++     +    G+ +++ +  L    ++  ++   ++ K     +  L E  +G  +++    E  F        D   ++ L    +   +C+  +IL  LI+  + +  V+    N  +   + V L++   L+   + L W LT     F    VS++RI QY +   + +  IN  +      +  +  I + + S  +       L NI   I  G+ + +VG+ G GKSSL  A+   +   +G + + G              +  + Q+  I + +LK N+    +Y +      +E   +   +  L  G   + G  G NLS GQKQ V LAR V +N  I +LD+  ++VD    + +F+ + S     ++ T I++ H +  +   D++L  + NGS+ E GS ++LL   N   +F
Sbjct: 1020 SKKIHSVLLDTVLRSTLQFFNAT----PSGRILNRFSKDLFIIDHTLNLNITD--IINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVV----NRFSLSASLVGLSISYALQVTGI-LNW-LTRQCAEFETNAVSIERIRQYTM---IPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITMNINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNLLKDGLYYDCGYMGANLSTGQKQLVCLARTVLKNSKIIILDEATASVDEDTDRRVFDAITSQ---FRNSTVIIIAHRIKTIIGCDKILYFE-NGSVVEFGSPQELLLKANGKFRF 1498

HSP 3 Score: 58.5362 bits (140), Expect = 5.609e-8
Identity = 67/263 (25.48%), Postives = 111/263 (42.21%), Query Frame = 3

Query: 4188 VLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQS--LETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARAL--------------LRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTD-IIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            VLKNI L     K I VVGR G GKSSL  A+   +    G++                 ++  +PQ+  I + TLR N+    +   ++IF    L+   L+  +  L      E GE GVNLS                       GQKQ + LARA+               + S + +LD+  ++VDV   + + + +   +   +  T +++ H +  +   D I V+ + G+I E  + ++L+      FKS  ++S
Sbjct:  642 VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQT-------------EGKIAYVPQEAWIQNNTLRNNI--LCTKSFNKIFYGTVLDACCLEYDIESLPNRDQTEIGERGVNLS----------------------GGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTE-FKSFLNES 866

[Close]

BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074226.1 (SMESG000074226.1)

HSP 1 Score: 1092.41 bits (2824), Expect = 0.000e+0
Identity = 665/1538 (43.24%), Postives = 941/1538 (61.18%), Query Frame = 3

Query:  360 DGLYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIF-WLTATIGYLLRLYCNIIRLLDASPYNIRNGXXXXXXXXXXXXXMNFLTHCFSSFSKDRLVLPNKIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDN-----RSPGWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNY-WIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQ--------------NRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNRAKNPSGG--QHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNAXXXXXXXXXXXXXXXXXHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFXXXXXXXXXXXXXXQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDXXXXXXXXXXXXVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDVETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPKNLLAMSDGIFKSL 4904
            D L I+SY  L  ++++A+   E+ RR  H    +LFI+ WL    GY +R Y N+I+ L  S   +R     +S+ I  L  ++ +    S +  + L        PE ++S+LS++TY W+D YIY+WF++EM DETSFDL   + S++N+    K             + +L   +  S  H +ED+  L    N     +  G  L  SL RVY   +      K   D  +  +P +LK+LL Y++N+  +Y W G  +A+ F F G+  SL EN CF ITS +++R+RAAL GMIY+KTLRL+ E R+  ++G+IVN+ SVD E++MN I ++W F+SCP QI+LAI+LLY E+ Y+IFAG+  I A  PLN ++M   +KFS  EL +KD R+ ILTEI +G+K++KMYAWEK F  KI  +R+ E++ I  VS  + ++ VLW+++PF +M  TF  ++     ++ITPEK FVSL LFN L+ P+++LPWGL+ +++A VS  RI  +L+  E    + N  + +     +  A IEI++GSFSW ++ + TLNNIN  + + KL+A+VG+VG GKSSL+SAILGEM+ +NG+V  +G IAYV QEAWIQN +L+ NIL T+ +N+  Y  +++AC L+ D+  LP  D+TEIGERG+NLSGGQKQRVSLARAVYQ              + DIYLLDDPLSAVD +VGQ LF  +ISN G+LK KTR+LVTHGL                                +++ FV E    N++ +    G  +HL D     + K+ L + SD  D  +      L  P+ P +R                                            K  R+ T GSQ      + ++N +   +K  + + +EE+ MSG V   +     K+ G+++F +++     F  LQ   N+WL    +   + N S     N S         R   K+Y+  Y IIGL   L V  +W  FT GS+ ASK IH  LL +VLRS ++FF+ TPSGRI+NRF+KD+  +DH++ +NI+D ++   ++  S++VI  VTPWF I  IP+ I Y L+Q+FYI +SRQ+RRLDS A+S V  H  ET  G ++IR+ + +  F+++    IDKS+KFK IQ  S+RWL LR++ILG L+VF +V+F+++ RFSL+ASLVGLSISY+LQ+T  LNWL RQ  E ETN V++ERIR+Y+ IP E+  + NN  S++W +NGNI  +++ L+Y   LP VLKNI ++ +GG+KIGVVGRTGAGKSSL LALFRLVE   G I ID +NI++IGLH LR++LTILPQDPVIFSGTL+ NLDPF  + DD++ +SLE + +  WV+ L+EG++Y+CG  G NLS+                      GQKQL+CLAR LL+KSK++ILDEATASVD ETDR V+  I+  F +STVIIIAHR+ TI+D D I+ +++G I+E  SPK LL+ S G FK+L
Sbjct:   26 DSLLIISYGSLMASMIVAVFTMELGRRGNHFFKVVLFIYSWLIFG-GYAIRFYNNLIKFLKYST-KMRMIYFSISSVIMILLFLSVIMDSISCYYTNDLT-----ENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYL-----------KENLRSPNIESEIHDIEDKKCLIGKKNFNEEFKYSGKFLIKSLCRVYFPIIFFGWILKIFRDILVLTLPLVLKLLLNYLKNKDLSYTWKGILMALLFFFQGLFGSLCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQIILAILLLYLELGYSIFAGVTAIGAIIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSLVLFNNLQLPILLLPWGLSQAISALVSFGRIENFLLASE----KENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKILYGTVLDACCLEYDIGSLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGL--------------------------------KWLPFVDEICVINDQGQISERGTYEHLMDFGT--EFKSFLNESSDKVDKNQN----NLIQPSAPNKR--------------------------------------------KRSRLSTSGSQGF----DDNENAEENYEKYFNDISQEEEIMSGRVSLNSIVWYFKATGIFVFASSILACVIFGVLQAIGNVWLGMLADTQSLLNNST---FNQS---------RNSAKFYINCYGIIGLGQLLAVILFWGGFTFGSLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHILNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKHNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSM----------------------GQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 1421

HSP 2 Score: 90.1225 bits (222), Expect = 1.378e-17
Identity = 116/511 (22.70%), Postives = 222/511 (43.44%), Query Frame = 3

Query: 1206 SIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVD---AERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAF----VSLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCN-EFMQFVQ--EYIEHNNR 2669
            S +I + L+  + R TL+  N       SG I+N  + D    + I+N  I     ++  + ++ +++++     +    G+ +++ +  L    ++  ++   ++ K     +  L E  +G  +++    E  F        D   ++ L    +   +C+  +IL  LI+  + +  VL    N  +   + V L++   L+   + L W LT     F    VS++RI QY +   + +  IN  +      +  +  I + + S  +       L NI   I  G+ + +VG+ G GKSSL  A+   +   +G + + G              +  + Q+  I + +LK N+    +Y +      +E   +   +  L  G   + G  G NLS GQKQ + LAR + +   I +LD+  ++VD    + + E +          T I++ H L  +   D+++ LD +GSI E GS K+LL + +  F    Q  EYI+H ++
Sbjct:  942 SKKIHSVLLDTVLRSTLQFFNAT----PSGRILNRFTKDLFIIDHILNLNITD--IINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVL----NRFSLSASLVGLSISYALQVTGI-LNW-LTRQCAEFETNAVSIERIRQYTM---IPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKHNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQ---FVSSTVIIIAHRLKTIIDCDKIIHLD-DGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 1433

HSP 3 Score: 64.3142 bits (155), Expect = 1.055e-9
Identity = 76/310 (24.52%), Postives = 125/310 (40.32%), Query Frame = 3

Query: 4041 VALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSXXXXXXXXXXXGLHDLRKRLTILPQDPVIFSGTLRENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCITHTHIFIYALFINFHNFIQAGQKQLLCLARAL--------------LRKSKVLILDEATASVDVETDRLVMHTI---REYFQASTVIIIAHRINTILDTD-IIVVMENGEIVEIDSPKNLLAMSDGIFKSLHDQS 4916
            V+  RI  +  + SE E D NN+          I  ++    + E     L NINL+    K I VVGR G GKSSL  A+   +    G++                 ++  +PQ+  I + TLR N+    S         L+   L+  +  L      E GE GVNLS                       GQKQ + LARA+               + S + +LD+  ++VDV   + + + +   +   +  T +++ H +  +   D I V+ + G+I E  + ++L+      FKS  ++S
Sbjct:  516 VSFGRIENF-LLASEKENDSNNSMPRKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQT-------------EGKIAYVPQEAWIQNNTLRNNILCTKSFNKILYGTVLDACCLEYDIGSLPNRDQTEIGERGVNLS----------------------GGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTE-FKSFLNES 788

The following BLAST results are available for this feature:

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ABCC2	2.874e-16	39.89	ATP binding cassette subfamily C member 2 [Source:...	[more]
ABCC3	0.000e+0	38.28	ATP binding cassette subfamily C member 3 [Source:...	[more]
ABCC3	5.744e-15	34.51	ATP binding cassette subfamily C member 3 [Source:...	[more]
ABCC1	7.511e-171	40.05	ATP binding cassette subfamily C member 1 [Source:...	[more]
ABCC1	7.511e-171	40.05	ATP binding cassette subfamily C member 1 [Source:...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mrp-1	0.000e+0	38.31	pep chromosome:WBcel235:X:576318:587483:-1 gene:WB...	[more]
mrp-2	0.000e+0	39.01	pep chromosome:WBcel235:X:563719:572701:-1 gene:WB...	[more]
mrp-1	0.000e+0	38.18	pep chromosome:WBcel235:X:576318:587483:-1 gene:WB...	[more]
mrp-1	0.000e+0	38.12	pep chromosome:WBcel235:X:576318:587483:-1 gene:WB...	[more]
mrp-1	0.000e+0	38.05	pep chromosome:WBcel235:X:576318:587483:-1 gene:WB...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MRP	0.000e+0	39.78	gene:FBgn0032456 transcript:FBtr0090025	[more]
MRP	0.000e+0	39.63	gene:FBgn0032456 transcript:FBtr0090020	[more]
MRP	0.000e+0	39.49	gene:FBgn0032456 transcript:FBtr0090022	[more]
MRP	0.000e+0	39.63	gene:FBgn0032456 transcript:FBtr0090023	[more]
MRP	0.000e+0	39.28	gene:FBgn0032456 transcript:FBtr0090026	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
abcc3	2.674e-12	38.65	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
abcc2	0.000e+0	39.69	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
abcc2	0.000e+0	39.83	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
abcc12	0.000e+0	32.41	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
abcc1	5.384e-168	37.18	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
septin9	1.018e-16	39.12	septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]	[more]
septin9	1.117e-16	38.79	septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]	[more]
septin9	6.452e-14	38.70	septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]	[more]
septin9	2.499e-15	38.62	septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]	[more]
septin9	2.700e-15	38.24	septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Abcc1	1.203e-17	39.21	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
Abcc3	0.000e+0	38.42	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
Abcc3	0.000e+0	38.55	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
Abcc2	5.815e-14	40.08	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
Abcc12	1.607e-14	31.98	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8CG09\|MRP1_RAT	5.811e-17	39.95	Multidrug resistance-associated protein 1 OS=Rattu...	[more]
sp\|Q6UR05\|MRP1_CANLF	1.050e-15	40.20	Multidrug resistance-associated protein 1 OS=Canis...	[more]
sp\|O35379\|MRP1_MOUSE	8.417e-17	39.21	Multidrug resistance-associated protein 1 OS=Mus m...	[more]
sp\|B2RX12\|MRP3_MOUSE	0.000e+0	38.22	Canalicular multispecific organic anion transporte...	[more]
sp\|O88563\|MRP3_RAT	0.000e+0	37.92	Canalicular multispecific organic anion transporte...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A210QB02	1.660e-20	39.72	Multidrug resistance-associated protein 1 OS=Mizuh...	[more]
A0A1I8HN92	1.649e-10	42.13	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8GTT5	8.414e-11	42.13	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8JGC8	0.000e+0	41.92	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A267EF93	0.000e+0	41.90	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
abcc1	0.000e+0	38.57	ATP binding cassette subfamily C member 1 [Source:...	[more]
abcc3	2.522e-16	38.69	ATP binding cassette subfamily C member 3 [Source:...	[more]
abcc3	3.331e-16	38.53	ATP binding cassette subfamily C member 3 [Source:...	[more]
abcc1	0.000e+0	38.53	ATP binding cassette subfamily C member 1 [Source:...	[more]
abcc3	3.142e-16	38.10	ATP binding cassette subfamily C member 3 [Source:...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
abcc3	0.000e+0	36.24	ATP-binding cassette, sub-family C (CFTR/MRP), mem...	[more]
ENSPMAT00000006454.1	1.582e-108	40.40	pep scaffold:Pmarinus_7.0:GL483531:32:7621:1 gene:...	[more]
ENSPMAT00000007076.1	5.933e-108	38.94	pep scaffold:Pmarinus_7.0:GL480539:10051:22495:1 g...	[more]
ENSPMAT00000001536.1	6.150e-101	37.50	pep scaffold:Pmarinus_7.0:GL479104:2125:31869:1 ge...	[more]
ABCC8	5.075e-93	38.19	ATP binding cassette subfamily C member 8 [Source:...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
BPT1	0.000e+0	33.65	ABC type transmembrane transporter of MRP/CFTR fam...	[more]
YOR1	3.474e-149	33.77	Plasma membrane ATP-binding cassette (ABC) transpo...	[more]
YCF1	2.555e-132	42.04	Vacuolar glutathione S-conjugate transporter; ABC-...	[more]
YBT1	8.406e-108	36.04	Transporter of the ATP-binding cassette (ABC) fami...	[more]
VMR1	1.203e-100	35.65	Vacuolar membrane protein; involved in multiple dr...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO36474	1.478e-16	41.37	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35071	1.194e-136	41.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43433	4.060e-121	48.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35250	3.465e-113	36.70	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46846	4.142e-113	36.02	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
abcc1	0.000e+0	37.65	multidrug resistance-associated protein 1 [Source:...	[more]
ENSORLT00000010371.2	0.000e+0	39.86	canalicular multispecific organic anion transporte...	[more]
abcc1	3.170e-13	37.91	multidrug resistance-associated protein 1 [Source:...	[more]
abcc1	3.300e-13	37.91	multidrug resistance-associated protein 1 [Source:...	[more]
abcc6a	0.000e+0	36.60	multidrug resistance-associated protein 1 [Source:...	[more]

BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000000273.1	1.258e-13	99.37	SMESG000000273.1	[more]
SMESG000000283.1	0.000e+0	55.60	SMESG000000283.1	[more]
SMESG000000283.1	1.404e-15	52.72	SMESG000000283.1	[more]
SMESG000074229.1	1.018e-17	41.90	SMESG000074229.1	[more]
SMESG000074226.1	1.378e-17	43.24	SMESG000074226.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027178 ID=SMED30027178|Name=Multidrug resistance-associated protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=5109bp
ATTCAGTATATAAATGTTTCAAATTTGTTTTTGCATATTGTGCAATTCGT
ATTTAACACTTTTTAATGAAGTCAGAGATTTGTCAAGATGGATTTTGGAA
CTCCACTTCATTTTCCAATGTTAAATATCCTATTTTTACTGAATGCTTCC
AATATGTGATATTATTAATTCCATCGGGAATTTTTATTATTCTTTTTACA
ATGTTTTTTATATTTAAAAAATACAAATCTCATCCAATAATAAAAGTTCC
TTGTACTTTTTACTATGGTCTGAAATTATCTAGTCAGGCGTTAATAATTA
TTTTGCTTATTGTGGAAATAATATTGGAAAAGTTACTTACGAAAAGTAAT
TCGCTAATAGATGGCTTATATATTATGTCATATGTTATATTATGCATAAC
TTTGGTTCTGGCCATGCTGCAGGCTGAAATCAGGCGGCGGACAATGCATC
CCGTGTGCTCCATACTTTTCATATTTTGGTTAACTGCCACTATAGGATAT
TTGCTGAGATTATATTGTAACATTATCCGCCTACTTGATGCTTCTCCGTA
CAATATCAGAAATGGGTTAATATTTCTCTCTGCTGCAATATTTTTCCTTT
TTCTAATGAACTTTTTGACTCATTGCTTTTCTTCATTCTCAAAAGACAGA
TTAGTTCTGCCAAATAAGATTCCTTGTCCAGAGGTTTACGCTTCAATTCT
GTCAAAATTGACCTATTCATGGCTGGATGCGTACATTTATAAGTGGTTTC
GGAAGGAAATGACAGATGAAACATCATTTGACCTAAGACGCCAAGATGAA
TCGACTAAAAATACAAATATACTGGAAAAGATATTTTACGACAAAATAAA
GATTTCTCATAATAGGAAAAGATATGACCTCCTCCAGAATTCAACCGCTA
GTGTTGCGCATCTAATGGAAGATGAAGATAAATTAACGAATCCTGATAAT
CGATCTCCAGGCTGGGTTTTATTTATCAGCCTAGCAAGAGTTTATGGGCT
TGAACTACTTCTTGCATGTGCTTTCAAAACAGTTCATGATTTCTCGATTT
ACGCAATGCCTTTTCTATTAAAAATCCTTTTGGAATATATCCAAAATAGA
AGCGATAATTATTGGATTGGATATTTCCTGGCTATTGCTTTTCTTTTCTT
TGGAGTTCTTAGCAGTTTAGCAGAGAACGGCTGCTTTTTTATTACATCCA
TCCTCAGCATCAGGATTCGAGCAGCGCTCATTGGAATGATTTATAGAAAG
ACTCTCAGACTGAACAATGAAATACGTAATAAATTCACTTCGGGTGAAAT
TGTCAATCTCATGAGTGTTGATGCTGAAAGAATTATGAATTGGATCATTT
TTGCATGGTTTTTCTTGTCATGTCCATTGCAAATTGTGTTGGCCATTATT
TTACTCTATCAGGAAATGAGCTACGCCATTTTCGCTGGTCTAGGATTAAT
AGTTGCATTTTTCCCTTTAAATGGCTTATTAATGAATCTTATGCAAAAAT
TTTCCACGATCGAATTAAAATGGAAAGATTTAAGAATAAAGATTTTAACT
GAAATTCTAAATGGAATTAAAGTTCTTAAAATGTATGCCTGGGAAAAATC
TTTTTTAGATAAAATCACTAATTTACGTGATACAGAAATGAGATATATTT
TAAGGGTTTCGGCAGCATTCGGTGTTGTATGTGTCTTGTGGGAAATATTG
CCGTTCTTGATAATGCTCGCAACATTCCTGTGCTATGTTTTAACCAGTGA
ATATAATATTATCACTCCTGAGAAGGCTTTCGTATCTTTAACACTTTTCA
ATTTGTTGCGTTTCCCCATGGTTGTTTTACCATGGGGGTTGACGGATTCG
ATGAATGCTTTTGTATCTCTCAAACGTATTGGACAATATTTAGTAGGAGA
AGAGTTGAATTTAACTGAAATCAATCATAGAGATTTTACAGATGATTCAG
CATTTAATTATGATGCTGCTATTGAAATTCGCGATGGTTCTTTTTCTTGG
AAAAAAGAAGACAAATTAACACTTAACAATATTAATTTTGAAATTGGTAG
AGGAAAATTAGTAGCCATCGTTGGAAAAGTTGGTACTGGGAAATCATCGC
TAATTTCCGCTATTTTGGGAGAAATGCATAGAATTAATGGTTCGGTTTCA
GTTCAGGGTACAATTGCATATGTTTCTCAGGAAGCCTGGATTCAGAATAA
ATCATTGAAAGAAAACATTTTATTTACTCAAGATTATAACGAAAAATTTT
ACGAGGATATCATAGAAGCATGCTCTTTAAAATCAGACTTAGAACAATTA
CCCGGGGGAGATGAAACTGAGATAGGAGAAAGAGGAATTAATCTTAGTGG
AGGACAAAAACAAAGAGTCAGTTTAGCAAGAGCAGTTTATCAAAATCGTG
ACATTTACCTATTAGATGATCCTCTTTCAGCAGTAGACGCGCATGTCGGG
CAACATTTATTTGAAAATGTTATTTCAAACAATGGAATTCTGAAAGACAA
AACTCGTATTCTTGTAACTCATGGTCTTAATTGGCTTCCGAAAGTTGATG
AGGTTCTAGTTTTGGATTCAAATGGATCAATATCAGAAAGAGGTTCTTTC
AAGGACCTGTTGAAAGATTGTAATGAATTCATGCAGTTCGTGCAGGAATA
TATTGAACATAATAATCGCGCCAAAAACCCCTCTGGTGGTCAACATTTAT
CAGATGAATCAGCTTTAGGAAAAGCTAAAAATCTATTACGACAATTATCG
GACAATGAAGATGTAGTTGAGGAAATCACTGATTTTGTGTTGACATCACC
CGCAGTGCCCATTCAGAGAAATGACAGTCACAGAGTATCAAATGCCAGTG
ACAGACTTTCTTCTTCAATTTCCAAATCTATTGACGGGTTTTCACGCCAT
GTAAAATATTTTGAAAATTCCAATTCTGGAGTATTTGAAGACGAAGACCC
TAAATCTCCAAGGATTATGACACCTGGTTCACAATCACGCCAAATATCTA
AAGAGACTGATCAAAATACTGACAGATTAATTGATAAACCGATAAGCCAA
TTGGTGGAAGAAGAACAAGCCATGTCAGGAACAGTAAAATGGGCCACTTA
TTCAATGTGCATCAAATCAAGGGGATTATGGTTGTTTATTGCCACTGTTG
CTATATATGCGGCGTTTACTGGCTTACAAGTTTTCAGTAATATATGGCTG
AAGAACTTTACGGAAGATTCAGATATTCAAAACGCTAGTCAACATATTTT
GTTGAATATTTCCGGATCTCCTTATTGGTCAAAAATAATCCGTGAACAAA
CTAAATATTATATGGTAATTTACACAATAATAGGTTTATGTATGACATTG
GTTGTTTGTTTCTACTGGGCTAGTTTCACTGTCGGATCTATAAATGCTTC
AAAAGTTATTCACAAGAAACTTCTCAGATCAGTTCTCCGTAGTCCTATGG
AATTTTTCGATACTACACCTTCAGGTCGAATAATTAATCGATTTAGTAAA
GATATTGAAAATCTTGATCATTTGATTCCCATGAATATTAGTGACTCTCT
TAGTTGTCTTTTCATTGTTTTTGCATCAATCATTGTTATTATATATGTCA
CGCCATGGTTTGCGATTGCAATAATTCCTCTAGCCATACTTTACTATTTG
ATTCAACTTTTCTACATACCAACTTCTCGGCAATCTCGTCGTTTAGACTC
TATTGCTGCATCGCCTGTTTTTAACCATTTCACTGAAACATTGCAAGGTG
TAGCGTTGATCCGAGCATTCAAAGAGCAGCAATACTTTCAAAATTTAAAT
CAAACTTTGATTGATAAAAGTAGCAAGTTCAAATTCATCCAACAATCCTC
AGTTCGTTGGTTGTCACTTCGAATTGAAATTCTCGGACAGTTGATGGTTT
TCGCTGCGGTTCTCTTTTCAATCATTGGTCGATTTAGTCTTACTGCCAGT
CTTGTTGGGTTATCAATATCATATTCTTTACAGATAACAGAATTCTTGAA
TTGGCTGTTGCGACAGTACACGGAACTGGAAACCAATTGCGTTGCATTGG
AAAGAATTCGAGAATACTCAAAAATTCCAAGCGAGGCAGAATGGGATTTA
AATAATGCTCCTTCTGACTCATGGCCTAATAATGGAAATATTACGTTTAA
AGATTATGATTTGAGATACCGAGAGGGACTCCCATTGGTTTTAAAGAATA
TAAATTTGCACTTTCATGGTGGAAAGAAAATCGGTGTTGTAGGAAGAACA
GGTGCTGGTAAATCCAGTTTAAACCTTGCCTTGTTTCGATTGGTTGAAGC
AGCTGGTGGAAGTATTATCATTGACAAGATTAATATTTCCACAATCGGAC
TTCATGATTTACGGAAGAGACTTACGATTTTACCTCAAGATCCAGTTATC
TTCTCAGGGACGTTAAGAGAAAACTTGGATCCATTTAGTTCGCATAAAGA
CGATGAAATTTTCCAATCCCTCGAAACAGCGCATTTGCAGTCATGGGTTT
CTGGATTGAGTGAGGGATTAGATTATGAATGTGGTGAAGGCGGAGTCAAT
TTATCGGTATGTATTACACACACGCATATATTTATATATGCATTGTTTAT
CAACTTTCATAATTTCATTCAGGCTGGCCAGAAACAACTGTTGTGCTTGG
CGAGAGCACTTTTGCGAAAGTCGAAAGTTTTGATTTTAGATGAAGCTACA
GCTTCTGTGGATGTTGAGACCGACCGATTGGTAATGCACACGATTCGGGA
ATATTTCCAGGCGAGCACAGTGATCATTATTGCCCACAGGATAAACACGA
TCCTCGACACCGACATAATTGTTGTCATGGAAAATGGGGAAATCGTAGAA
ATTGATTCTCCGAAAAATCTTCTCGCAATGTCAGATGGAATATTCAAATC
TTTGCATGATCAAAGTTTAAATAATGATTTGTGATGATGAAAGAGATGGA
AAACTATTGATTTGTATCTGTGCTTCAGTTGATCATTTTCATATTGAACT
TGTTTAATAAATATTTTCTTGCCATTCCTTTCTGTTTACATTTGACCGAG
AATTTGTTATGTTGTTATTATTACAAATGTGCTTTATTTTATCGCAATAA
ATATTTTCG

protein sequence of SMED30027178-orf-1

>SMED30027178-orf-1 ID=SMED30027178-orf-1|Name=SMED30027178-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1623bp
MKSEICQDGFWNSTSFSNVKYPIFTECFQYVILLIPSGIFIILFTMFFIF
KKYKSHPIIKVPCTFYYGLKLSSQALIIILLIVEIILEKLLTKSNSLIDG
LYIMSYVILCITLVLAMLQAEIRRRTMHPVCSILFIFWLTATIGYLLRLY
CNIIRLLDASPYNIRNGLIFLSAAIFFLFLMNFLTHCFSSFSKDRLVLPN
KIPCPEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNT
NILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSPGW
VLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNYW
IGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLN
NEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQE
MSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNG
IKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIM
LATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFV
SLKRIGQYLVGEELNLTEINHRDFTDDSAFNYDAAIEIRDGSFSWKKEDK
LTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTI
AYVSQEAWIQNKSLKENILFTQDYNEKFYEDIIEACSLKSDLEQLPGGDE
TEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFE
NVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLK
DCNEFMQFVQEYIEHNNRAKNPSGGQHLSDESALGKAKNLLRQLSDNEDV
VEEITDFVLTSPAVPIQRNDSHRVSNASDRLSSSISKSIDGFSRHVKYFE
NSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEE
QAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTE
DSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFY
WASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDIENL
DHLIPMNISDSLSCLFIVFASIIVIIYVTPWFAIAIIPLAILYYLIQLFY
IPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLID
KSSKFKFIQQSSVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLS
ISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPS
DSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKS
SLNLALFRLVEAAGGSIIIDKINISTIGLHDLRKRLTILPQDPVIFSGTL
RENLDPFSSHKDDEIFQSLETAHLQSWVSGLSEGLDYECGEGGVNLSVCI
THTHIFIYALFINFHNFIQAGQKQLLCLARALLRKSKVLILDEATASVDV
ETDRLVMHTIREYFQASTVIIIAHRINTILDTDIIVVMENGEIVEIDSPK
NLLAMSDGIFKSLHDQSLNNDL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Vocabulary: **molecular function**
Term	Definition
GO:0008559	xenobiotic-transporting ATPase activity
GO:0015431	glutathione S-conjugate-exporting ATPase activity
GO:0016787	hydrolase activity
GO:0022857	transmembrane transporter activity
GO:0042910	xenobiotic transporter activity
GO:0005524	ATP binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0016887	ATPase activity
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0008514	organic anion transmembrane transporter activity

Vocabulary: **biological process**
Term	Definition
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0050729	positive regulation of inflammatory response
GO:0071716	leukotriene transport
GO:0006810	transport
GO:0055085	transmembrane transport
GO:0015711	organic anion transport

Vocabulary: **INTERPRO**
Term	Definition
IPR036640	ABC1_TM_sf
IPR003593	AAA+_ATPase
IPR011527	ABC1_TM_dom
IPR027417	P-loop_NTPase
IPR003439	ABC_transporter-like
IPR017871	ABC_transporter_CS

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR003593	AAA+ ATPase domain	SMART	SM00382	AAA_5	coord: 662..931 e-value: 1.0E-10 score: 51.6 coord: 1382..1589 e-value: 5.3E-10 score: 49.2
IPR003439	ABC transporter-like	PFAM	PF00005	ABC_tran	coord: 1373..1543 e-value: 6.1E-24 score: 85.1
IPR003439	ABC transporter-like	PFAM	PF00005	ABC_tran	coord: 653..787 e-value: 8.5E-24 score: 84.6
IPR003439	ABC transporter-like	PROSITE	PS50893	ABC_TRANSPORTER_2	coord: 636..861 score: 21.555
IPR003439	ABC transporter-like	PROSITE	PS50893	ABC_TRANSPORTER_2	coord: 1358..1612 score: 16.107
IPR011527	ABC transporter type 1, transmembrane domain	PFAM	PF00664	ABC_membrane	coord: 1032..1304 e-value: 6.6E-40 score: 137.5 coord: 314..585 e-value: 1.4E-30 score: 106.9
IPR011527	ABC transporter type 1, transmembrane domain	PROSITE	PS50929	ABC_TM1F	coord: 1022..1320 score: 41.038
IPR011527	ABC transporter type 1, transmembrane domain	PROSITE	PS50929	ABC_TM1F	coord: 315..597 score: 35.957
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 612..879 e-value: 1.6E-74 score: 252.6
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 1340..1611 e-value: 1.3E-79 score: 269.2
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 956..981
None	No IPR available	PANTHER	PTHR24223:SF350	CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2	coord: 58..1612
None	No IPR available	PANTHER	PTHR24223	FAMILY NOT NAMED	coord: 58..1612
None	No IPR available	CDD	cd03250	ABCC_MRP_domain1	coord: 636..838 e-value: 7.7851E-112 score: 350.231
None	No IPR available	CDD	cd18603	ABC_6TM_MRP1_2_3_6_D2_like	coord: 1021..1332 e-value: 2.87779E-125 score: 391.456
None	No IPR available	CDD	cd18595	ABC_6TM_MRP1_2_3_6_D1_like	coord: 316..605 e-value: 4.58514E-118 score: 371.417
None	No IPR available	CDD	cd03244	ABCC_MRP_domain2	coord: 1354..1596 e-value: 4.69729E-105 score: 332.151
None	No IPR available	TMHMM	TMhelix		coord: 374..393
None	No IPR available	TMHMM	TMhelix		coord: 350..369
None	No IPR available	TMHMM	TMhelix		coord: 1019..1041
None	No IPR available	TMHMM	TMhelix		coord: 426..448
None	No IPR available	TMHMM	TMhelix		coord: 167..189
None	No IPR available	TMHMM	TMhelix		coord: 298..320
None	No IPR available	TMHMM	TMhelix		coord: 453..475
None	No IPR available	TMHMM	TMhelix		coord: 1162..1193
None	No IPR available	TMHMM	TMhelix		coord: 65..87
None	No IPR available	TMHMM	TMhelix		coord: 1079..1101
None	No IPR available	TMHMM	TMhelix		coord: 28..50
None	No IPR available	TMHMM	TMhelix		coord: 1262..1284
None	No IPR available	TMHMM	TMhelix		coord: 132..154
None	No IPR available	TMHMM	TMhelix		coord: 100..122
None	No IPR available	TMHMM	TMhelix		coord: 527..549
IPR036640	ABC transporter type 1, transmembrane domain superfamily	GENE3D	G3DSA:1.20.1560.10		coord: 282..611 e-value: 6.8E-21 score: 76.7 coord: 986..1339 e-value: 5.8E-44 score: 152.6
IPR036640	ABC transporter type 1, transmembrane domain superfamily	SUPERFAMILY	SSF90123	ABC transporter transmembrane region	coord: 1018..1337
IPR036640	ABC transporter type 1, transmembrane domain superfamily	SUPERFAMILY	SSF90123	ABC transporter transmembrane region	coord: 303..605
IPR017871	ABC transporter, conserved site	PROSITE	PS00211	ABC_TRANSPORTER_1	coord: 760..774
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 1348..1612
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 630..860