TNF receptor-associated factor

Overview


Name	TNF receptor-associated factor
Smed ID	SMED30027110
Length (bp)	1501

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of TNF receptor-associated factor (SMED30027110) t-SNE clustered cells

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30027110) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor-associated factor (SMED30027110) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30027110) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027110

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30027110	h1SMcG0019403	dd_Smed_v4_7291_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30027110	h1SMcG0019403	dd_Smed_v4_7291_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30027110	h1SMcG0019403	dd_Smed_v4_7291_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30027110	h1SMcG0019403	dd_Smed_v4_7291_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 121.709 bits (304), Expect = 2.932e-29
Identity = 107/448 (23.88%), Postives = 199/448 (44.42%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMT----------EESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELP---------------TDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF-----MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            C  C  +L  P Q+ CG R+C SC+   L S +  C      C+E  V   + +  D+   + +LA+++ C    + C  +  L +L+ HLK+   +C F E+ C   + K + + + +           E + SH       +  +  ++ +L+     K K+I  L NQ+ +  ++  ++  +++ + S + ++ ++      +L                 DS++ + +      TE ESV  +  +  +  +G   S+      M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ S++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++
Sbjct:   53 CEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQESIV--KDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKN---DCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC---KSQVPMIALQVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQV-ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVD 478

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BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 110.153 bits (274), Expect = 4.585e-25
Identity = 111/500 (22.20%), Postives = 200/500 (40.00%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSH--------------------------SINCPFHEMGCSH------------------------------------SNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELP---------------TDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF-----MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            C  C  +L  P Q+ CG R+C SC+   L S +  C      C+E  V   + +  D+   + +LA+++ C    + C  +  L +L+ HLK+                              C + E  CSH                                    S   +Q +  H    +  H  LL E   +++ ++ +L+     K K+I  L NQ+ +  ++  ++  +++ + S + ++ ++      +L                 DS++ + +      TE ESV  +  +  +  +G   S+      M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ S++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++
Sbjct:   53 CEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQESIV--KDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQV-ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVD 536

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Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSH--------------------------SINCPFHEMGCSH------------------------------------SNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELP---------------TDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF-----MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            C  C  +L  P Q+ CG R+C SC+   L S +  C      C+E  V   + +  D+   + +LA+++ C    + C  +  L +L+ HLK+                              C + E  CSH                                    S   +Q +  H    +  H  LL E   +++ ++ +L+     K K+I  L NQ+ +  ++  ++  +++ + S + ++ ++      +L                 DS++ + +      TE ESV  +  +  +  +G   S+      M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ S++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++
Sbjct:   53 CEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTA----CQESIV--KDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQV-ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVD 536

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BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF6 (TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036])

HSP 1 Score: 107.071 bits (266), Expect = 3.632e-24
Identity = 112/482 (23.24%), Postives = 195/482 (40.46%), Query Frame = 2

Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCS---------HSN-----------VKSQAMVQHMTEES----------------YSHTILLMESIQNMKNEIEILRENLQRKEKTIG--------KLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQ---INQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP + C  K EL+    HL+ H  +C F  M C          H N           V        M  E                 Y +TIL+ E + N   +++     +     T G         L   L+ NT  H + +A     +S++ +   I +    +     ++   + QD  I + T        + ET S +    +    +    +  I A +    + WKI +F   ++  + +   VI+S  FY+ + GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ  ++  V   +      K   + F +P+          +G  T +HL +L      +K+  +L RC ++
Sbjct:   46 SSSFMEEIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELR----HLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPN-HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELT-------AKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQ--SEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQRTFIKDDTLLVRCEVS 500

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Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCS---------HSN-----------VKSQAMVQHMTEES----------------YSHTILLMESIQNMKNEIEILRENLQRKEKTIG--------KLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQ---INQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP + C  K EL+    HL+ H  +C F  M C          H N           V        M  E                 Y +TIL+ E + N   +++     +     T G         L   L+ NT  H + +A     +S++ +   I +    +     ++   + QD  I + T        + ET S +    +    +    +  I A +    + WKI +F   ++  + +   VI+S  FY+ + GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ  ++  V   +      K   + F +P+          +G  T +HL +L      +K+  +L RC ++
Sbjct:   46 SSSFMEEIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELR----HLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPN-HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELT-------AKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQ--SEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQRTFIKDDTLLVRCEVS 500

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-1 (TNF Receptor Associated Factor (TRAF) homolog; TRF-1 [Source:UniProtKB/TrEMBL;Acc:G5EG80])

HSP 1 Score: 75.8702 bits (185), Expect = 1.505e-14
Identity = 44/132 (33.33%), Postives = 62/132 (46.97%), Query Frame = 2

Query:  812 ICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAP-FEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQ 1204
            +CD   +    Y   E D      R++R +SA  +       E   P   WKI+    R  EAKS     I+S PF SHR GYK+       G G      +S++  +++GEFD +L WP  R + I L+DQ
Sbjct:  222 LCDEITDLKGTYELMERDMGSFNDRQTRILSAAET-----CTEMFGPQLIWKIDKLQQRTNEAKSGADTTIFSVPFMSHRFGYKMMACACLFGDGSSAGKSISLYVLLLKGEFDPTLEWPFHRAIKISLLDQ 348

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BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-2 (TNF Receptor Associated Factor (TRAF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N586])

HSP 1 Score: 58.151 bits (139), Expect = 5.160e-9
Identity = 28/71 (39.44%), Postives = 40/71 (56.34%), Query Frame = 2

Query:  986 VQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLV 1198
            V+  K+K  + IYS+PFYSH  GYK+     P G G     + SVF  +++GE+DD L WP    V   ++
Sbjct:  172 VKATKNKSHRSIYSQPFYSHGYGYKMMAVAAPYGDGLAFREYFSVFVCLMKGEWDDILEWPFRCDVTFSIL 242

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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0334401)

HSP 1 Score: 77.0258 bits (188), Expect = 9.180e-15
Identity = 44/153 (28.76%), Postives = 76/153 (49.67%), Query Frame = 2

Query:  959 WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQ--VSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            WKI D+  ++ EA+ K    + S PFY+ + GYKL+  +  NG G  ENTH+SV+  ++ GE+D  L WP    +   L +Q +   Q  V++ +      ++FQ   ++P       D   +G P  I  + L ++   +K   +  R  ++
Sbjct:  326 WKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEP-------DQLGFGFPRFIS-HELLHSRPFIKGDTVFLRVKVD 470

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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0077429)

HSP 1 Score: 76.6406 bits (187), Expect = 1.222e-14
Identity = 44/153 (28.76%), Postives = 76/153 (49.67%), Query Frame = 2

Query:  959 WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQ--VSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            WKI D+  ++ EA+ K    + S PFY+ + GYKL+  +  NG G  ENTH+SV+  ++ GE+D  L WP    +   L +Q +   Q  V++ +      ++FQ   ++P       D   +G P  I  + L ++   +K   +  R  ++
Sbjct:  335 WKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEP-------DQLGFGFPRFIS-HELLHSRPFIKGDTVFLRVKVD 479

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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf-like (gene:FBgn0030748 transcript:FBtr0074275)

HSP 1 Score: 60.4622 bits (145), Expect = 2.123e-9
Identity = 28/91 (30.77%), Postives = 50/91 (54.95%), Query Frame = 2

Query:  959 WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSD 1231
            W+I+D+  +++E+K +   +++S  F +   GY LRL +  NG G W+  ++    +++ GE+D  L WP   Q  I + DQ +N     D
Sbjct:  338 WRIKDYSKKLEESK-QYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQCTNVADAED 427

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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf-like (gene:FBgn0030748 transcript:FBtr0074273)

HSP 1 Score: 59.6918 bits (143), Expect = 3.261e-9
Identity = 28/91 (30.77%), Postives = 50/91 (54.95%), Query Frame = 2

Query:  959 WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSD 1231
            W+I+D+  +++E+K +   +++S  F +   GY LRL +  NG G W+  ++    +++ GE+D  L WP   Q  I + DQ +N     D
Sbjct:  316 WRIKDYSKKLEESK-QYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQCTNVADAED 405

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf-like (gene:FBgn0030748 transcript:FBtr0308606)

HSP 1 Score: 59.3066 bits (142), Expect = 3.434e-9
Identity = 28/91 (30.77%), Postives = 50/91 (54.95%), Query Frame = 2

Query:  959 WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSD 1231
            W+I+D+  +++E+K +   +++S  F +   GY LRL +  NG G W+  ++    +++ GE+D  L WP   Q  I + DQ +N     D
Sbjct:  259 WRIKDYSKKLEESK-QYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQCTNVADAED 348

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BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 122.865 bits (307), Expect = 1.224e-29
Identity = 113/487 (23.20%), Postives = 195/487 (40.04%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKN------------------------EIEILRENLQR-------------KEKTIGKLQNQLRNNTLQHNKEIAIMKKDI----------------SLLKNVSKIEKGTTAELPTDSIQINQD------------GTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTH-LSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C SCI K ++   + CP   +      V +   L  D+FA + +L++ VKC    C  K EL+ L +HL      C F    C     +    + H+ E    H +  + +  +                           E+E++R+ L                  T G  +   RN   QH +E   M                    S   ++S  ++G +A  P DS Q  Q+            G +    ++       ++T  +     R + +S   S R + A +    + W++E+F + ++  ++    V++S PFY+ R GYKL LR++         ++ +S+F   ++GEFD  L WP++  + + ++DQV  +  +         + D Q  F +P   T + +   +G  T +HL +L   G  +K   +L RC + 
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLS----QCRFATAPCP--QCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKMTRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSP-DSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIE----VMETKPDLQA-FQRP---TVMRNPKGFGYVTFLHLQALRQRG-FVKEDVLLVRCEVT 521

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Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKN------------------------EIEILRENLQR-------------KEKTIGKLQNQLRNNTLQHNKEIAIMKKDI----------------SLLKNVSKIEKGTTAELPTDSIQINQD------------GTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTH-LSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C SCI K ++   + CP   +      V +   L  D+FA + +L++ VKC    C  K EL+ L +HL      C F    C     +    + H+ E    H +  + +  +                           E+E++R+ L                  T G  +   RN   QH +E   M                    S   ++S  ++G +A  P DS Q  Q+            G +    ++       ++T  +     R + +S   S R + A +    + W++E+F + ++  ++    V++S PFY+ R GYKL LR++         ++ +S+F   ++GEFD  L WP++  + + ++DQV  +  +         + D Q  F +P   T + +   +G  T +HL +L   G  +K   +L RC + 
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLS----QCRFATAPCP--QCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKMTRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSP-DSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIE----VMETKPDLQA-FQRP---TVMRNPKGFGYVTFLHLQALRQRG-FVKEDVLLVRCEVT 521

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Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKN------------------------EIEILRENLQR-------------KEKTIGKLQNQLRNNTLQHNKEIAIMKKDI----------------SLLKNVSKIEKGTTAELPTDSIQINQD------------GTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTH-LSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C SCI K ++   + CP   +      V +   L  D+FA + +L++ VKC    C  K EL+ L +HL      C F    C     +    + H+ E    H +  + +  +                           E+E++R+ L                  T G  +   RN   QH +E   M                    S   ++S  ++G +A  P DS Q  Q+            G +    ++       ++T  +     R + +S   S R + A +    + W++E+F + ++  ++    V++S PFY+ R GYKL LR++         ++ +S+F   ++GEFD  L WP++  + + ++DQV  +  +         + D Q  F +P   T + +   +G  T +HL +L   G  +K   +L RC + 
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLS----QCRFATAPCP--QCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKMTRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSP-DSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIE----VMETKPDLQA-FQRP---TVMRNPKGFGYVTFLHLQALRQRG-FVKEDVLLVRCEVT 521

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BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf4a (tnf receptor-associated factor 4a [Source:ZFIN;Acc:ZDB-GENE-040308-1])

HSP 1 Score: 100.523 bits (249), Expect = 2.534e-22
Identity = 107/465 (23.01%), Postives = 189/465 (40.65%), Query Frame = 2

Query:  191 CTICEKILNRPYQ-SPCGCRYCYSCIEKHLKSGNKYCPK---PTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSHSIN---CPFH--------------EMGCSHSNVKSQAMVQHMTEESYS--HTILLMESIQ-NMKNEIEILRENLQRKEKTIGKLQNQ--------LRNNTLQ----HNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVH---------YTESETDSHFS------GTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQ----VSNKIQVSDKYRWKSVEKDFQVIFHKP-STRTEIADYYF-YGTPTLIHLNSLFNNGKLLKNGAILFRCSI 1408
            C +C K +  P Q S CG R+C +C+++ L  G   CP+   P D  +         +  D    + +LA+ ++C   E+ C    ++K L  H  + + N   CP                +  C    VK +      T E+Y     I   ES+    K    ++R  L +   T    + Q           +T+Q    H     +   +     N+++ +     +    S  +     +C F E    H         + E  T SH +      G +R   +     +  +S + D     WK+ D+  ++QEAK + +   +S PFY+HR GYKL++    NG G  E +HLS++  ++ GE+D+ L WP   +V   ++DQ    +S    +++ +      K+FQ    KP S+R  + +    +G P  I    +      +++ +I  + SI
Sbjct:   18 CPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAK---------IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQSHFSTCAFNVIPCPNRCSVKLTRRDLPEHLQHDCPKRKVKCEFCGSEFTGEAYENHQGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPNQCGTPNIAREDLANHVKESCGSALV-----LCPFKEAGCKHRCPKMAIGRHLEESTKSHLTMMCSLVGRQRQEILELRREMEELSVSHDGV-LIWKLTDYSRKLQEAKLRNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSIYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQ----KPCSSRNSLDESTLGFGYPKFISHEEI-KKRNYIRDNSIFLKASI 462

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Query:  191 CTICEKILNRPYQ-SPCGCRYCYSCIEKHLKSGNKYCPK---PTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSHSIN---CPFH--------------EMGCSHSNVKSQAMVQHMTEESYS--HTILLMESIQ-NMKNEIEILRENLQRKEKTIGKLQNQ--------LRNNTLQ----HNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVH---------YTESETDSHFS------GTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQ----VSNKIQVSDKYRWKSVEKDFQVIFHKP-STRTEIADYYF-YGTPTLIHLNSLFNNGKLLKNGAILFRCSI 1408
            C +C K +  P Q S CG R+C +C+++ L  G   CP+   P D  +         +  D    + +LA+ ++C   E+ C    ++K L  H  + + N   CP                +  C    VK +      T E+Y     I   ES+    K    ++R  L +   T    + Q           +T+Q    H     +   +     N+++ +     +    S  +     +C F E    H         + E  T SH +      G +R   +     +  +S + D     WK+ D+  ++QEAK + +   +S PFY+HR GYKL++    NG G  E +HLS++  ++ GE+D+ L WP   +V   ++DQ    +S    +++ +      K+FQ    KP S+R  + +    +G P  I    +      +++ +I  + SI
Sbjct:   18 CPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAK---------IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQSHFSTCAFNVIPCPNRCSVKLTRRDLPEHLQHDCPKRKVKCEFCGSEFTGEAYENHQGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPNQCGTPNIAREDLANHVKESCGSALV-----LCPFKEAGCKHRCPKMAIGRHLEESTKSHLTMMCSLVGRQRQEILELRREMEELSVSHDGV-LIWKLTDYSRKLQEAKLRNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSIYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQ----KPCSSRNSLDESTLGFGYPKFISHEEI-KKRNYIRDNSIFLKASI 462

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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 105.531 bits (262), Expect = 1.366e-23
Identity = 111/495 (22.42%), Postives = 196/495 (39.60%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDD-----------CREQCVDINNNLQFDHFANKNVLAI--------------KVKCPEKACDTKAELKNLMEHL------------------------KSHSINCPFHEMGCSH-SNVKS--------QAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQ--------------LRNNTLQHNKEIAIMKKDISLLKNVSK-IEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF--MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN*AHL 1423
            C  C  +L  P Q+ CG R+C +C+   L S +  C    D+           CR + + +    + +    K ++ +              ++ CP   C  K   K+L +H+                        K   ++CP   + C H  +VKS        Q +  H    +  H  L+ E    ++ ++ +L+     K K+I  L NQ              LRNN  +  +   +++     LK++ K I          D ++ N +      ++ E +    +  +     T+ +R   M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ  ++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++ + L
Sbjct:   48 CEKCRLVLCNPRQTECGHRFCETCMNAILSSTSPQCMACEDNITKDKVFKDNCCRREVLALQMFCRNETRGCKELITLGNLLIHLKSDCQFEELSCPRADCKEKVIRKDLSDHIEKTCKYRETPCKFCRNQVPLVEMQKHEDVDCPSVVISCPHMCSVKSLLRSEGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEIRNLRQTGDEADGMKSNYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVDTSDL 533

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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 98.2117 bits (243), Expect = 3.241e-21
Identity = 98/418 (23.44%), Postives = 177/418 (42.34%), Query Frame = 2

Query:  263 IEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKN-----LMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQ--------------LRNNTLQHNKEIAIMKKDISLLKNVSK-IEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF--MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN*AHL 1423
            +  H++   KY   P   CR Q   +    +     + +  ++ + CP   C  K+ L++     L+E + + S  C F   GC+     +Q +  H    +  H  L+ E    ++ ++ +L+     K K+I  L NQ              LRNN  +  +   +++     LK++ K I          D ++ N +      ++ E +    +  +     T+ +R   M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ  ++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++ + L
Sbjct:  157 LSDHIEKTCKYRETPCKFCRNQVPLV----EMQKHEDVDCPSVVISCPH-MCSVKSLLRSELNAHLLECVNAPS-TCSFKRYGCTFKGT-NQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEIRNLRQTGDEADGMKSNYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVDTSDL 558

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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: egf (epidermal growth factor [Source:Xenbase;Acc:XB-GENE-951823])

HSP 1 Score: 95.5153 bits (236), Expect = 2.596e-20
Identity = 116/510 (22.75%), Postives = 203/510 (39.80%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCS--HSNVKSQAMVQHMTEESYSHTIL-----LMESIQNMKNE----------IEILRENLQRKEKT------------------IGKLQNQLRNNTLQHNKEI--AIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEE-------SVHYTESETDSHFSGTRRS-------------------RFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIY----------------SKPFYSHRNG-------YKLRLRVN---PNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +   E      N L  D+FA + +L+++VKCP + C    EL+    HL+ H + C F  + CS   S+    ++ +H  EE     I      L  ++++  N            E  + NL R++                     G  +   RN+  +H +E   A M+     L++ S      T+ +P        D + CD ++ E       +VH + + + +  +   R+                   R + A    +C   NE     +  I    NR+ E +S+    I+                 +P   H  G       YKL LR++   P+   +    ++S+F   ++GE+D  L WP++  + + ++DQ S  + + D+      + +  + F +P   T   +   +G  T +HL +L    + +KN  +L RCS+ 
Sbjct:   58 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACILKSIRDAGHKCPVDNESLME------NQLFPDNFAKREILSLRVKCPSQGCTETMELR----HLERHLVRCDFAGVECSQCQSSFPKYSLQKHKFEECPRRQIFCENCALAMALEDKLNHDQTCPLAYVTCEYCQTNLIREQMPAHYSMDCTMAPIPCMYYEFGCTEKMQRNDLARHLQEFTQAHMRMMAQTLRSFSS-SVTPTSHMP--------DISFCDPSQFEPAPPSVATVHSSHTPSQNDCTQETRNLRETIEQLEGRLVRQDHQIRELIAKMETQCTYVNE----LKHTIRSLDNRLGEMESQQCSGIFIWRINNFNSLLKNQEEERPVVIHSQGFYTGKPGYKLCLRLHLQLPS--AQRCANYISLFVHTMQGEYDSLLPWPLQGTIRLSILDQ-SEGVAMQDQEEVMDTKPEL-LAFQRP---TVARNPKGFGYVTFMHLQAL-KQRQYVKNDTLLVRCSVT 536

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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: slc12a1 (solute carrier family 12 member 1 [Source:Xenbase;Acc:XB-GENE-479925])

HSP 1 Score: 90.8929 bits (224), Expect = 7.150e-19
Identity = 97/414 (23.43%), Postives = 166/414 (40.10%), Query Frame = 2

Query:  263 IEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTIL----LMESIQNMKNEIEIL--RENLQRKEKTIGKLQNQLR----------------NNTLQHNKEIA-IMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFS------GTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFN--NGKLLKNGAILFRCSIN 1411
            ++ HL+S  K   +    C++    IN  +    +         V CP  AC        L +HL      CP  E+ C+ SN     MV+    + +  T L    L    +NMK E ++L  ++NL  KE  I +L + ++                 N+L   K +A  + K + L + V ++     + L    I    + T    +  E+        D  F          + +  S     R +          WKI D+  + +EA    +  I+S+ FY+   GY+L  R   NG G  + + LS++F +++GEFD  L WP +++V + L+DQ   K  ++D +R       F+    +P +   IA     G P       L N  NG  +K+  +  +  ++
Sbjct:   85 LKGHLESECKLRQEACIYCKQTMASINLTIHVGLYCQ----LYPVPCP-NACPVTCPRAELDKHL----CECPEAELQCTFSNYGCNVMVKRGKVKEHEDTFLRDHMLYVLNRNMKLEEQVLGLQQNLDLKEHQIQQLSDTVKWCEKECHQFGQFTGSNGNSLSSTKTLASYIDKSMWLEEQVIQLVSKEHSRLDLRPILDTLESTKQRLSTLEAYKDRIDNLDGQFKKHDVLLSNHKMQMTSNEERFRLVEGTSYNGKLIWKITDYERKKREAMEGRAVSIFSQHFYTSWCGYRLCARAYLNGDGSGKGSFLSLYFVVMKGEFDSILLWPFKQKVTLMLLDQSGKKNHITDVFRADPNSSSFK----RPDSEMNIAS----GCPRFASHAQLENPKNGCYIKDDTLFIKIVVD 481

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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: slc12a1 (solute carrier family 12 member 1 [Source:Xenbase;Acc:XB-GENE-479925])

HSP 1 Score: 88.9669 bits (219), Expect = 3.653e-18
Identity = 84/350 (24.00%), Postives = 143/350 (40.86%), Query Frame = 2

Query:  455 LKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTIL----LMESIQNMKNEIEILR--ENLQRKEKTIGKLQNQLR----------------NNTLQHNKEIA-IMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFS------GTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFN--NGKLLKNGAILFRCSIN 1411
            L  H   CP  E+ C+ SN     MV+    + +  T L    L    +NMK E ++L   +NL  KE  I +L + ++                 N+L   K +A  + K + L + V ++     + L    I    + T    +  E+        D  F          + +  S     R +          WKI D+  + +EA    +  I+S+ FY+   GY+L  R   NG G  + + LS++F +++GEFD  L WP +++V + L+DQ   K  ++D +R       F+    +P +   IA     G P       L N  NG  +K+  +  +  ++
Sbjct:  191 LDKHLCECPEAELQCTFSNYGCNVMVKRGKVKEHEDTFLRDHMLYVLNRNMKLEEQVLSVLQNLDLKEHQIQQLSDTVKWCEKECHQFGQFTGSNGNSLSSTKTLASYIDKSMWLEEQVIQLVSKEHSRLDLRPILDTLESTKQRLSTLEAYKDRIDNLDGQFKKHDVLLSNHKMQMTSNEERFRLVEGTSYNGKLIWKITDYERKKREAMEGRAVSIFSQHFYTSWCGYRLCARAYLNGDGSGKGSFLSLYFVVMKGEFDSILLWPFKQKVTLMLLDQSGKKNHITDVFRADPNSSSFK----RPDSEMNIAS----GCPRFASHAQLENPKNGCYIKDDTLFIKIVVD 532

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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf6 (TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072])

HSP 1 Score: 120.168 bits (300), Expect = 1.323e-28
Identity = 116/490 (23.67%), Postives = 206/490 (42.04%), Query Frame = 2

Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEH----------------------LKSHSI-NCPFHEMGCSHSNVKSQAMVQHMTEES---------YSHTILLMESIQNMKN------------EIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLK---NVSKIEKGTTAELPT--------DSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP K C  K EL++L +H                      + +H I +CP  ++ C +  V      + + ++S         Y  TIL+ E + N  +             +    E +QR       L   L+ NT  H + +A    +++L     + +   +G   E P         +S  + QD  I + T        + ET S + G  +    +    +  + A +    + WKI +F   ++  + +   VI+S  FY+ R GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ    I+ + +    +  K   + F +P+          +G  T +HL +L   G  +K+  +L RC ++
Sbjct:   46 SSSFMEEIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNH-----LARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELT-------AKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDA--KPELLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQGTFIKDDTLLVRCEVS 508

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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 111.309 bits (277), Expect = 1.352e-25
Identity = 112/500 (22.40%), Postives = 200/500 (40.00%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSH--------------------------SINCPFHEMGCSH------------------------------------SNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELP---------------TDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF-----MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            C  C  +L  P Q+ CG R+C SC+   L S +  C      C+E    I + +  D+   + +LA++V C    + C  +  L +L+ HLK+                              C + E  CSH                                    S   +Q +  H    +  H  LL E   +++ ++ +L+     K K+I  L NQ+ +  ++  ++  +++ + S + ++ ++      +L                 DS++ + +      TE ESV  +  +  +  +G   S+      M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ S++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++
Sbjct:   52 CEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTA----CQESI--IKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQA-ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVD 535

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Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSH--------------------------SINCPFHEMGCSH------------------------------------SNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELP---------------TDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF-----MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            C  C  +L  P Q+ CG R+C SC+   L S +  C      C+E    I + +  D+   + +LA++V C    + C  +  L +L+ HLK+                              C + E  CSH                                    S   +Q +  H    +  H  LL E   +++ ++ +L+     K K+I  L NQ+ +  ++  ++  +++ + S + ++ ++      +L                 DS++ + +      TE ESV  +  +  +  +G   S+      M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ S++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++
Sbjct:   52 CEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTA----CQESI--IKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQA-ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVD 535

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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 105.145 bits (261), Expect = 1.655e-23
Identity = 96/416 (23.08%), Postives = 178/416 (42.79%), Query Frame = 2

Query:  263 IEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCP----FHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELP---------------TDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRF-----MSATSSLRCISANEDIAPFE---------WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +  H++   KY       C+ Q   I    +     + +   + V CP K C  +  L++ +    S  +N P    F   GC      +Q +  H    +  H  LL E   +++ ++ +L+     K K+I  L NQ+ +  ++  ++  +++ + S + ++ ++      +L                 DS++ + +      TE ESV  +  +  +  +G   S+      M +   +R    +      E         WKI D+  R QEA    +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF I+ GE+D  L WP +++V + L+DQ S++  + D ++       F+    KP+    IA     G P  +   ++  NG  +K+  I  +  ++
Sbjct:  161 LRDHVEKACKYREATCSHCKSQVPMI----KLQKHEDTDCPCVVVSCPHK-CSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGT-NQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQA-ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK----KPTGEMNIAS----GCPVFV-AQTVLENGTYIKDDTIFIKVIVD 560

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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 93.9745 bits (232), Expect = 5.729e-20
Identity = 86/334 (25.75%), Postives = 150/334 (44.91%), Query Frame = 2

Query:  437 KNLMEHLKSHS---INCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNV-----SKIEK-GTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +   +H+++ S   + C FH +GCS        MV+  TE    H       +Q ++  + +L  +    + + G L NQ+    LQ  +   I+++ I+  +N+      ++E+   TAE  +   +++QD       E  S    + E          +      S L  +S  + +  F WKI DF  + QEA +  +  I+S  FY+ R GYK+ LRV  NG G    THLS+FF +++G  D  L WP  ++V + L+D  +N+  V D +R       FQ    +P +   IA     G P    ++ +      +++ AI  +  ++
Sbjct:  200 ETFQDHVRACSKCRVLCRFHTVGCSE-------MVE--TENLQDH------ELQRLREHLALLLSSFLEAQASPGTL-NQVGPELLQRCQ---ILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKI-----EALSNKVQQLERSIGLKDLAMADLEQKVSELE-VSTYDGV--FIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDH-NNREHVIDAFRPDVTSSSFQ----RPVSDMNIAS----GCPLFCPVSKMEAKNSYVRDDAIFIKAIVD 497

HSP 2 Score: 54.6842 bits (130), Expect = 1.910e-7
Identity = 35/111 (31.53%), Postives = 55/111 (49.55%), Query Frame = 2

Query:  161 VDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPT-DDCREQCVDI--NNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPF 484
            + T L +  +C+ C+ IL RP+Q+ CG RYC  C+   L SG + C     +   E+ + I  +++   D+ A + V ++   CP   C  K  LK   E+   H   CPF
Sbjct:   24 LGTRLEAKYLCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLK---EYESCHEGLCPF 131

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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q6IWL4|TRAF6_DANRE (TNF receptor-associated factor 6 OS=Danio rerio OX=7955 GN=traf6 PE=1 SV=2)

HSP 1 Score: 122.865 bits (307), Expect = 9.240e-29
Identity = 113/487 (23.20%), Postives = 195/487 (40.04%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKN------------------------EIEILRENLQR-------------KEKTIGKLQNQLRNNTLQHNKEIAIMKKDI----------------SLLKNVSKIEKGTTAELPTDSIQINQD------------GTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTH-LSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C SCI K ++   + CP   +      V +   L  D+FA + +L++ VKC    C  K EL+ L +HL      C F    C     +    + H+ E    H +  + +  +                           E+E++R+ L                  T G  +   RN   QH +E   M                    S   ++S  ++G +A  P DS Q  Q+            G +    ++       ++T  +     R + +S   S R + A +    + W++E+F + ++  ++    V++S PFY+ R GYKL LR++         ++ +S+F   ++GEFD  L WP++  + + ++DQV  +  +         + D Q  F +P   T + +   +G  T +HL +L   G  +K   +L RC + 
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLS----QCRFATAPCP--QCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCREKMTRNELAQHMQEFTQMHMRYMAEFLRSQTLNNCTMPSAAAHLSSDDRGASARSP-DSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTRELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIE----VMETKPDLQA-FQRP---TVMRNPKGFGYVTFLHLQALRQRG-FVKEDVLLVRCEVT 521

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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|P70196|TRAF6_MOUSE (TNF receptor-associated factor 6 OS=Mus musculus OX=10090 GN=Traf6 PE=1 SV=2)

HSP 1 Score: 120.168 bits (300), Expect = 9.252e-28
Identity = 116/490 (23.67%), Postives = 206/490 (42.04%), Query Frame = 2

Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEH----------------------LKSHSI-NCPFHEMGCSHSNVKSQAMVQHMTEES---------YSHTILLMESIQNMKN------------EIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLK---NVSKIEKGTTAELPT--------DSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP K C  K EL++L +H                      + +H I +CP  ++ C +  V      + + ++S         Y  TIL+ E + N  +             +    E +QR       L   L+ NT  H + +A    +++L     + +   +G   E P         +S  + QD  I + T        + ET S + G  +    +    +  + A +    + WKI +F   ++  + +   VI+S  FY+ R GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ    I+ + +    +  K   + F +P+          +G  T +HL +L   G  +K+  +L RC ++
Sbjct:   46 SSSFMEEIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNH-----LARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELT-------AKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDA--KPELLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQGTFIKDDTLLVRCEVS 508

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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|B5DF45|TRAF6_RAT (TNF receptor-associated factor 6 OS=Rattus norvegicus OX=10116 GN=Traf6 PE=2 SV=1)

HSP 1 Score: 117.472 bits (293), Expect = 6.402e-27
Identity = 118/484 (24.38%), Postives = 207/484 (42.77%), Query Frame = 2

Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEH----------------------LKSHSI-NCPFHEMGCSHSNVKSQAMVQHMTEES---------YSHTILLMESIQNMKN------------EIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISL-LK--NVSKIEKGTTAELPTDSIQINQ-DGTICDFTEEESVHYTESETDS-HFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP K C  K EL++L +H                      +  H I +CP  ++ C +  V      + + ++S         Y  TIL+ E + N  +             +    E +QR       L   L+ NT  H + +A    +++L L+  + S   +G   E P     + Q +G +     +      + ET S H S  +R+   S    +  + A +    + WKI +F   ++  + +   VI+S  FY+ R GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ    I+ + +    +  K   + F +P+          +G  T +HL +L   G  +K+  +L RC ++
Sbjct:   46 SSSFMEEIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNH-----LARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMHVSELKRT-IRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVIRQNHEEVMDA--KPELLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQGTFIKDDTLLVRCEVS 508

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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|B6CJY4|TRAF6_CERAT (TNF receptor-associated factor 6 OS=Cercocebus atys OX=9531 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 108.997 bits (271), Expect = 4.885e-24
Identity = 113/482 (23.44%), Postives = 198/482 (41.08%), Query Frame = 2

Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCS---------HSNV--------------KSQAMVQHMTEE-------------SYSHTILLMESIQNMKNEIEILRENLQRKEKTIG--------KLQNQLRNNTLQHNKEIAIMKKDISLLKN---VSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP + C  K EL+    HL+ H  +C F  + C          H N+                 A+V    +E              Y +TIL+ E + N   +++     +     T G         L   L+ NT  H + +A     +SL+ +   VS++          +   + QD  I + T        + ET S +    +    +    +  I A +    + WKI +F   ++  + +   VI+S  FY+ + GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ  ++  V   +      K   + F +P+          +G  T +HL +L      +K+  +L RC ++
Sbjct:   46 SSSFMEEIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELR----HLEDHQAHCEFALVDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAALVAFEDKEIHDQNCPLANVICEYCNTILIREQMPN-HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSLIPDSGYVSEVRNFQETIHQLEGRLVRQDHQIRELT-------AKMETQSTYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQ--SEAPVRQNHEEIMDAKPDLLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQRTFIKDDTLLVRCEVS 500

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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|B6CJY5|TRAF6_MACMU (TNF receptor-associated factor 6 OS=Macaca mulatta OX=9544 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 108.997 bits (271), Expect = 5.068e-24
Identity = 113/482 (23.44%), Postives = 198/482 (41.08%), Query Frame = 2

Query:  110 NSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCS---------HSNV--------------KSQAMVQHMTEE-------------SYSHTILLMESIQNMKNEIEILRENLQRKEKTIG--------KLQNQLRNNTLQHNKEIAIMKKDISLLKN---VSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPN-GFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +S F E  Q    YD + D  L S   C IC   L    Q+PCG R+C +CI K ++     CP   +      + + N L  D+FA + +L++ VKCP + C  K EL+    HL+ H  +C F  + C          H N+                 A+V    +E              Y +TIL+ E + N   +++     +     T G         L   L+ NT  H + +A     +SL+ +   VS++          +   + QD  I + T        + ET S +    +    +    +  I A +    + WKI +F   ++  + +   VI+S  FY+ + GYKL +R++      +    ++S+F   ++GE+D  L WP +  + + ++DQ  ++  V   +      K   + F +P+          +G  T +HL +L      +K+  +L RC ++
Sbjct:   46 SSSFMEDIQ---GYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNE------ILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELR----HLEDHQAHCEFALVDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAALVAFEDKEIHDQNCPLANVICEYCNTILIREQMPN-HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSLIPDSGYVSEVRNFQETIHQLEGRLVRQDHQIRELT-------AKMETQSTYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQ--SEAPVRQNHEEIMDAKPDLLAFQRPTIPRNPKG---FGYVTFMHLEAL-RQRTFIKDDTLLVRCEVS 500

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BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A0F7GY08 (TNF receptor associated factor 5 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 139.813 bits (351), Expect = 3.695e-35
Identity = 69/146 (47.26%), Postives = 97/146 (66.44%), Query Frame = 2

Query:  932 ANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGK 1369
              E IAPFEWKI +FM + + A S     +YS+PFYSH+NGYK++LR++PNG    +  +LSV F II GE+DD L WPM +QV I L++Q +  + +S +Y++ SV K  + IF KP +R E  + YF+GT  L + + LFNN K
Sbjct:   41 VKEHIAPFEWKITNFMEKHERAISGEKLTVYSEPFYSHKNGYKIQLRIDPNGDEAVKALYLSVSFGIIGGEYDDELDWPMTKQVKISLINQKTGLVHISKRYKFDSVLKKSKCIFFKPISRFEDDEDYFFGTLKLSNFSVLFNNQK 186

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BLAST of TNF receptor-associated factor vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 1.979e-34
Identity = 126/482 (26.14%), Postives = 216/482 (44.81%), Query Frame = 2

Query:  104 MANSKFQEIYQLLTDYDFQ-VDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFAN----KNVLAIKVKCPEKACDTKAELKNLMEHLKS---HSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEI---------------EILR-----------------ENLQRKE-------KTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSI 1408
            M  SK   + +LL+ Y+ + VD  + +DL+C +C K++    +S CGC YCY+CI  +L   + YCP    +C+E  +    NL+ D F N      +  I VKCP   C+  +EL  L EHL      S+ CP   +GC    +    M +H+T++   HT L+M     +K+EI               E+LR                 E L+ K+       + I +++N++         E+  +K DI + +   +  K     + +  I+ NQ   + D  +E  +   +   DS+     R R M+    L  +  N D+  F W+IE++       K +    +YS  F SH   + L L +  +  G W          I++GE DD L WPM R V + +++Q S K   +  +++ + +++ +  F +P  + E  DY   GT +L+  + +     +L N +I+  C +
Sbjct:    1 MIPSKLDNVQELLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYL----NLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLDKCTPESVECPCVTIGCEEEPLLKDEMAKHLTDQVLRHTQLIMSFCNELKSEINHNNETTKEDISHLKEVLRVQKALNDEKTAQMEFLIEELRNKDNMILVLSQDIQEVKNEMITLLTSKESELKKLKSDIQIFRQEIEFMKNDLEVVGSTDIK-NQ---VKDLKKE--IFGIKMNIDSN--NEERERKMNNLIRLNKLCPNVDM-DFMWRIEEY-----SKKRRTVTDVYSDSFQSHNYKFCLNLYIYGDNLGLW--------CVIMKGEKDDFLEWPMRRTVTLSIIEQDSLKTHKTTVFQYDTYQRNKKA-FDRP--KDERNDYCI-GTDSLVRYSYIKETPMILVNDSIIVACVV 452

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BLAST of TNF receptor-associated factor vs. TrEMBL
Match: I1ZID8 (TNF receptor associated factor-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 125.176 bits (313), Expect = 1.409e-29
Identity = 64/208 (30.77%), Postives = 121/208 (58.17%), Query Frame = 2

Query:  122 QEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSI---NCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLK 736
            ++I +LL  Y+F+V+  +  +L C +C+ +L    QS CGCR+C  CI +++  GN YCP  T +C+E+ + I +N+  D+  N+ +  ++VKCPE+ C    EL ++ EHL+  ++   NCPF  +GC+   +  Q +  H+   ++ H+ L+++ I NM+N+       L  KE  + +  N ++N+    N+ + ++  +I ++K
Sbjct:    4 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDF----FGLTTKEVELREDINLIKNHFQSQNEIMMLINSEIEIIK 207

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BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A498M8A6 (TNF receptor-associated factor OS=Labeo rohita OX=84645 GN=ROHU_027055 PE=3 SV=1)

HSP 1 Score: 131.339 bits (329), Expect = 3.135e-29
Identity = 113/465 (24.30%), Postives = 201/465 (43.23%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSH--SNVKSQAMVQHMTEESYSHTIL--------------LMESIQNMKN------EIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKD--------ISLLKNVSKIEKGTTAELPTDSIQINQ------------DGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYK--LRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C SCI+K ++   + CP   +      V +   L  D+FA + +L++ V+CP   C  K EL+     L+ HS  C F  + C     +V+   + +H +++     +               + E I    N      ++E++R+ + R E     L   ++  T  H + +A   +          S+  + S  E+G +A  P DS Q  Q            +G +    ++       +ET        R +  +   + R + A +    + W++E+F   ++  ++    V++S PFY+ R GYK  LRL +      +  N ++S+F   ++GEFD  L WP++  + + ++DQV  +  V         + D Q  F +P   T + +   +G  T +HL +L   G  +K+  +L RC + 
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCNSCIKKSIRDTGQKCPVDNE------VLLEEQLFPDNFAKREILSLTVRCPNAGCSDKMELR----QLEKHSSQCKFATVQCPQCLESVRKSHLDEHKSQQCLQRLLTCPDCAESFVYAGKQIHEQICPFANTVCEYCDMELIRDQMPRNE-----LAQHMQEFTQMHMRYMAEFLRSQTLNSCPVPSVATHSSSDERGASARAP-DSCQCRQELMNLRETVLELEGRLVRQDQQIRELCIHNETQKIQVTDLRRKLGTLEEATRELEAQQYQGIYVWRLENFSVHLRSQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSN-YISLFVHTMQGEFDSQLSWPLQGMIRLSVLDQVEGQHHVE----VMETKPDLQA-FQRP---TVLRNPKGFGYVTFLHLQALRQRG-FVKDDVLLVRCEVT 495

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BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A553RF85 (TNF receptor-associated factor OS=Danionella translucida OX=623744 GN=DNTS_014115 PE=3 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 1.066e-28
Identity = 122/473 (25.79%), Postives = 209/473 (44.19%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHL---KSHSINCP--FHEMGCSHSNV-KSQAMVQH-MTEESYSHT-ILLMESIQNMKNEIEILRENLQR-------------KEKTIGKLQNQLRNNTLQHNKEIAI--MKKDISLLKN--------------VSKIEKGTTAELPTDSIQINQ------------DGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVN---PNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD + D  L S   C IC   L    Q+PCG R+C SCI+K ++   + CP   +      V + + L  D+FA + +L++ V+C    C+ K EL+ L +HL   K  + +CP     +  SH +  KSQ   Q  MT  + + T I    + +    E+E++RE L                  T G  +   RN   QH +E     M+     L+N               S  E+G +++ P DS Q  Q            +G +    ++       ++T  +     R +  S   + R + A +    + W++E+F N ++  ++    V++S PFY+ R GYKL LR++   PN      + ++S+F   ++GEFD  L WP++  + + +++QV  +  V         + D Q  F +P+ +        +G  T +HL +L   G  +K   +L RC ++
Sbjct:   52 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCLSCIKKSIRDTGQKCPVDNE------VLLEDQLFPDNFAKREILSLTVRCSNIGCNNKMELRQLEKHLSQCKFSTAHCPQCLESVLKSHLDEHKSQFCSQRLMTCPACAGTFICPFANTRCEYCEMELIREQLSLHCDTDCLKAPVACTFSTFGCREKMARNELAQHMQEFTQMHMRYMAEFLRNQTLTNCLMPPSTGYCSPDERGASSK-PPDSCQCKQELMNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLTSLEEATRELEAQQFQGVYIWRLENFSNHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPN--APRCSNYISLFVHTMQGEFDSQLSWPLQGTITLAVLNQVDGQHHVE----VMETKPDLQA-FQRPTVQRNPKG---FGYVTFLHLQALRQRG-FVKEDVLLVRCEVS 506

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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 120.553 bits (301), Expect = 6.799e-29
Identity = 112/463 (24.19%), Postives = 197/463 (42.55%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSH--SNVKSQAMVQHMTEESYSHTILLMESIQNM---------KNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMK----KDISLLKNVSKI--EKGTTAELPTDSIQIN-QDGTICDFTEE-----ESVHYTES----------------ETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVN---PNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD   D  L S   C IC   L    Q+PCG R+C  CI K ++   + CP   +      V   + L  D+FA + +L++ V+C    C  K EL+    HL++H  +C F  + C     +V    + +H+ +E     I   +  +N+           + + L+  +       G  +  LRN+   H +E   M      D+   + ++ +      +A  PTDS   + +    C   +E     E+V   ES                ET S      R +  S   S+R + A +    + W++E F   ++  ++    V++S PFY+ R GYKL LR++   PN   +  N ++S+F   ++GEFD  L WP++  + + ++DQ   +  V         + D Q  F +P+ +        +G  T + L +L   G  +++  ++ RC + 
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNE------VLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELR----HLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQLASHCDTDCLKAPVACTFSIFGCREKMLRNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELSIRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNA-PRCSN-YISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQHHVE----VMETKPDLQA-FQRPTVQRNPKG---FGYVTFMQLQALHQRG-FVRDDVLMVRCEVT 497

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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 114.005 bits (284), Expect = 1.216e-26
Identity = 116/487 (23.82%), Postives = 200/487 (41.07%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSH--SNVKSQAMVQHMTEESYSHTILLMESIQNM--------------KNEI------EILRENLQRKEKT-------------IGKLQNQLRNNTLQHNKEIAIMK----KDISLLKNVSKI--EKGTTAELPTDSIQIN-QDGTICDFTEE-----ESVHYTES----------------ETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVN---PNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD   D  L S   C IC   L    Q+PCG R+C  CI K ++   + CP   +      V   + L  D+FA + +L++ V+C    C  K EL+    HL++H  +C F  + C     +V    + +H+ +E     I   +  +N+               N +      E++R  L     T              G  +  LRN+   H +E   M      D+   + ++ +      +A  PTDS   + +    C   +E     E+V   ES                ET S      R +  S   S+R + A +    + W++E F   ++  ++    V++S PFY+ R GYKL LR++   PN   +  N ++S+F   ++GEFD  L WP++  + + ++DQ   +  V         + D Q  F +P+ +        +G  T + L +L   G  +++  ++ RC + 
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNE------VLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELR----HLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQFHEQLCLFANTVCEYCNMELIRNQLASHCDTDCLKAPVACTFSIFGCREKMLRNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELSIRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNA-PRCSN-YISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQHHVE----VMETKPDLQA-FQRPTVQRNPKG---FGYVTFMQLQALHQRG-FVRDDVLMVRCEVT 521

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Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSH--SNVKSQAMVQHMTEESYSHTILLMESIQNM--------------KNEI------EILRENLQRKEKT-------------IGKLQNQLRNNTLQHNKEIAIMK----KDISLLKNVSKI--EKGTTAELPTDSIQIN-QDGTICDFTEE-----ESVHYTES----------------ETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVN---PNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            YD   D  L S   C IC   L    Q+PCG R+C  CI K ++   + CP   +      V   + L  D+FA + +L++ V+C    C  K EL+    HL++H  +C F  + C     +V    + +H+ +E     I   +  +N+               N +      E++R  L     T              G  +  LRN+   H +E   M      D+   + ++ +      +A  PTDS   + +    C   +E     E+V   ES                ET S      R +  S   S+R + A +    + W++E F   ++  ++    V++S PFY+ R GYKL LR++   PN   +  N ++S+F   ++GEFD  L WP++  + + ++DQ   +  V         + D Q  F +P+ +        +G  T + L +L   G  +++  ++ RC + 
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVDNE------VLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELR----HLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQFHEQLCLFANTVCEYCNMELIRNQLASHCDTDCLKAPVACTFSIFGCREKMLRNDLALHMQEFTQMHMRYMADVLRNQTINGLISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELSIRNETQSTQMTELRKKLASLEESMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNA-PRCSN-YISLFVHTMQGEFDSQLSWPLQGTIRLAVLDQAEGQHHVE----VMETKPDLQA-FQRPTVQRNPKG---FGYVTFMQLQALHQRG-FVRDDVLMVRCEVT 521

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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:103024022])

HSP 1 Score: 101.293 bits (251), Expect = 1.380e-22
Identity = 106/479 (22.13%), Postives = 192/479 (40.08%), Query Frame = 2

Query:  140 LTDYDFQVDTFLYSDLICTICEKILNRPYQ-SPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC--PEKACDTKAELKNLMEHLKSHSIN---CPFH--------------EMGCSHSNVKSQAMVQHMTEESYS--HTILLMESIQ-NMKNEIEILRENLQ--------RKEKTIGKLQNQLRNNTLQ----HNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVH---------YTESETDSHFS------GTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQ----VSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIAD--YYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSI 1408
            +  YD++          C +C K +  P Q S CG R+C +C+++ L  G   CP+      +Q       +  D    + +LA+ ++C   E+ C    ++K L  H  + + N   CP                +  C    VK +      T E++     I   ES+    K    ++R  L         ++ +       +   +T+Q    H     +   +     N+++ +  T  +    S  +     +C F +    H         + E  T SH +      G +R   +     +  +S + D     WK+ D+  ++QEAK   +   +S PFY+HR GYKL++    NG G  E +HLS++  ++ GE+D+ L WP   +V   ++DQ    +S    +++ +      K+FQ    KPS+     D     +G P  I  + +      +++ AI  + SI
Sbjct:    1 MPGYDYKFLEKPKRRFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPE------DQLPLDYAKIYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCPNRCAVKLTRRDLPEHLQHDCPKRKVKCEFCGSEFTGEAFENHQGICPQESVYCENKCGARMMRRLLAQHTMAECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPNQCGTPNIAREDLATHVKESCGSALV-----LCPFKDAGCKHRCPKLAIGRHLEETTKSHLTMMCSLVGRQRQEIIELRREMEELSVSHDGV-LIWKLNDYSRKLQEAKLHNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSIYIRVLPGEYDNLLEWPFAYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQ----KPSSSRNSLDESTLGFGYPKFISHDEI-RKRNYIRDNAIFLKASI 462

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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: ENSAMXT00000035169.1 (pep primary_assembly:Astyanax_mexicanus-2.0:9:3354744:3362219:1 gene:ENSAMXG00000029095.1 transcript:ENSAMXT00000035169.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 86.6557 bits (213), Expect = 1.260e-19
Identity = 47/151 (31.13%), Postives = 80/151 (52.98%), Query Frame = 2

Query:  959 WKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            WKI D+  R  EA +  +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF ++ GE+D  L WP +++V + L+DQ   +  + D ++       F+    +P+    IA     G P  +   ++  NG  +K+  I  + +++
Sbjct:    8 WKIRDYKRRKAEAVASKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQGPARKHLGDAFKPDPNSSSFR----RPTGEMNIAS----GCPLFVA-QTVLENGTYIKDDTIFIKVTVD 149

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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000074.1 (pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-1 gene:ENSPMAG00000000066.1 transcript:ENSPMAT00000000074.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 102.064 bits (253), Expect = 1.720e-23
Identity = 87/365 (23.84%), Postives = 155/365 (42.47%), Query Frame = 2

Query:  392 KVKCPEKA--CDTKAELKNLM-EHLKSHSINCP-------FHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLR---------NNTLQHNKEI-AIMKKDISL----LKNVSKIEKGTTAELPTDSIQINQDGTICDF---------TEEESVHYTESETDSHFSG----------------TRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLI 1339
            + +CP     C  K E +++  E L SH   CP       F + GC +     Q + +H +  +  H  L+     N++ ++ +L+  L  +  +   L  ++R           T   N+ +  ++++ +++    L  + +  +GTT     D+++ + DGT              EE     T S T +  +                 TR +        L   S N  +    WKI D+  R Q+A S  +  +YS+PFY+   GY++  R   NG G    THLS+FF ++ GE+D  L WP  ++V + L+DQ + + Q+SD ++       F+    +P++   IA     G P  +
Sbjct:   95 ETRCPRYPIPCPNKCEEQSIAREELVSHLGICPYKQAECFFSQFGCKYKGTL-QGLKEHESGATQQHLSLVTARSANLELKVSMLQSQLAERANSADLLGTRVRELEKELISVGQTASKNESVLCVVQRMLAVQTERLLRLQESMQGTTRRADHDALRGDLDGTAATLHELGTRVAAIEESGGSVTHSSTPTRLAALDSALSRHDTQLFAHDTRLAEMDLRFQVLETASYNGKLV---WKIRDYARRKQDAVSGRTLSLYSQPFYTSPFGYRMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLPWPFRQRVTLTLLDQGAARRQLSDTFKPDPASSSFR----RPTSDMNIAS----GCPLFV 447

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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002130.1 (pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 gene:ENSPMAG00000001936.1 transcript:ENSPMAT00000002130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 98.9821 bits (245), Expect = 1.083e-22
Identity = 90/384 (23.44%), Postives = 153/384 (39.84%), Query Frame = 2

Query:  251 CYSCIEK-HLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCP---EKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLME--------------SIQNMKNEIEILRENLQRKEK------TIGKLQNQLRNNTL----QHNKEI----------------AIMKKDISLLK-NVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQ 1267
            C + +++  L +    CP   + C+     +  +L   H   +      + CP   E+    +AEL   M      +  C FH +GC+     S+++ +H      SH  L++               SI++  N  E+L + + + E+      T+    N    +TL    QHN+++                A +++D++ L+  +  +E       P                 EE  H  E     H          +A   L+ +          WKI D+  R QEA S  +  +YS+PFY+   GYK+  R   NG G    THLS+FF ++ GE+D  L WP  R+V + L+DQ + +  +SD +        F+
Sbjct:   13 CGTSVQRTRLAAHRASCPHRAEFCKYCSAAVTCSLLERHH-KEECAQYPLPCPNNCEEHGIPRAELSQHMSACAMSTKLCGFHMLGCTFKQGTSESVREHEESAVRSHFTLVISRNSELELQCARLQCSIEDHTNMSEMLTQRVAQLEQDLSHWSTLTGSNNTRLGSTLEMLTQHNEQLQSLHVAQRAPQRDADTAALRRDMATLRERLRALEAALGNPGPC----------------EERCHMHEQRLTMH-----DGLLDTAERRLQVLETAGYSGKLVWKIRDYARRKQEAASGRTLSLYSQPFYTSPFGYKMCARAYLNGDGVGRGTHLSLFFVVMRGEYDALLEWPFRRRVTLSLLDQGAARRHLSDTFTPDPASGSFR 374

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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 65.4698 bits (158), Expect = 1.316e-11
Identity = 37/119 (31.09%), Postives = 56/119 (47.06%), Query Frame = 2

Query:  149 YDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCI--EKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGC 499
            Y+   +  L S   C IC   L  P Q+PCG R+C +CI     L+     CP       +  V     L  D+FA + +L++ V+CP K C  + EL+ L E    H + C + ++ C
Sbjct:   51 YEADFEPPLESKYECPICLMALREPVQTPCGHRFCRACILHSMRLRDAGPKCPV------DNAVLHEGQLFPDNFAKREILSLTVRCPNKPCGHRGELRALQE----HQLRCEYAQVPC 159

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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008091.1 (pep scaffold:Pmarinus_7.0:GL477915:34322:50582:-1 gene:ENSPMAG00000007312.1 transcript:ENSPMAT00000008091.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.447 bits (119), Expect = 4.737e-7
Identity = 26/76 (34.21%), Postives = 43/76 (56.58%), Query Frame = 2

Query:  953 FEWKIEDFMNRVQEAKSKLSKV--IYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPME 1174
            F WKI+  +NR++EA +   +   I S  F++ R GY+LRLR+  +G       H+S +  +  G +D +L WP +
Sbjct:  327 FLWKIKHVINRLREAGNGAERPPQIDSPAFFTTRYGYRLRLRLCRSG------EHVSAYAMLGPGPYDATLAWPYQ 396

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BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO49464 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG36])

HSP 1 Score: 113.62 bits (283), Expect = 5.911e-27
Identity = 120/521 (23.03%), Postives = 188/521 (36.08%), Query Frame = 2

Query:  140 LTDYDFQVDTF---LYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNK----------------------------YCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLK-----------------------------SHSINCP----------------------------FHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQL---RNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQIN--------QDGTICDFTEEESVHYTESETDSHFSGT----RRS------------RFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQ-VSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSL 1354
            + D  FQ + F   L     C +C   L  P Q+PCG R+C  C+E  L+  +K                            YCP      R+   +   +LQ+      N     V+C    C  K   ++L  HL+                              H + CP                            F + GC H     +A+  H  +++  H  LL+ + QN +     +   L + EK   K Q Q+   R      N+ +   +  +++++     ++   AEL  + IQ+         QD  +     E S     S       GT    RR             +       L+ + A      + WKI+++  R QE  S  +  IYS PFY  R GYK   RV PNG G  + +HLS+FF ++ GEFD  L WP  ++V   L+DQ  +++  + D +R       F+    +P++   IA     G P  I   +L
Sbjct:    1 MQDEGFQTELFVEPLDPKYRCPVCGNALKHPVQTPCGHRFCEGCLEPILRGPSKCPVDGEELKIDGVFKDVCCRREILCLACYCPN-----RQLGCEWMKDLQYLEEHRANCEYKGVQCHNPGCQEKVAKRDLEAHLERCEFKPSDCQYCLQRIPAASMEDHLQTCEKHPVVCPHCGAEGICRDELLHHQTNICEQAELPCSFAKHGC-HFKGTREALETHFRDQASVHVNLLLTATQNEEKARSEMAAKLSQMEKERAKQQEQMYEQREALAVANQNLRTYQGKLNVIERSVAEQRRELAEL-KERIQLQEVEAAIREQDRRLGMIENEASRGAAPSSGPGSMGGTMALERRQDRNEHQLALHDIQLAEHDLKLQMLEATSYDGTYIWKIDEYTRRYQEGVSGKTPSIYSPPFYVGRYGYKACARVYPNGDGMGKGSHLSLFFVLMRGEFDALLPWPFRQKVTFKLLDQ--DRVHDIGDTFRPDPTSSSFK----RPTSNMNIAS----GCPLFISHTNL 504

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJK8])

HSP 1 Score: 110.153 bits (274), Expect = 5.678e-26
Identity = 113/450 (25.11%), Postives = 191/450 (42.44%), Query Frame = 2

Query:  155 FQVDTFLY---SDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKN---------------------------LME-----------HLK--------------SHSINCP-------FHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIM--KKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAK-------------------SKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVE 1255
            F +D F+     +LIC IC  ++N P  + CG  YC  CIEK   +G +    P D+ + +   I  + + D      VL+++VKC    C  K EL+                            LME           H K               H  +CP       F E+GC+    +S A  +H      +H  +  E+I++ K +I  L + L        K++ +L+  +  H KE+  +  K D ++  N  +IE   + E    S  I+++    D  ++E    +E+         R++R   A  S  C +   D   F W+I ++ ++ ++A                    S    ++ S PFY+ R GYK+RL+  PNG+G  + THLS+   I++GE+D  L WP  R++ + L++Q       S+++R ++VE
Sbjct:   15 FDLDQFIIPPNDELICAICHMVVNEPVLTSCGHSYCKYCIEKWC-NGKEVVTCPVDNEQLKPSQIFPDKKTDRI----VLSLEVKCTNNPCRWKGELRQKQKHLKICSHKAVKCILEGCNVKVPRILMEKHTNTCGWRLLHCKPCNLSYPKKDEETVQHKDDCPLAFLPCRFSEIGCTFKGRES-ARDEHCESAVQTHLHIACETIRDNKEQISDLHKELD-------KVRQELQTKSCDHMKEVNAIREKHDEAIRDNKGQIE-ALSKEHGIASNTIHENKEQLDTLKKELGIASET--------IRKNRDQIAKLSTACKTQYTD-GTFVWRICNYKDKYKKAVAFATNQEVKGGNSDSDDDISMAGDIMVSLPFYTSRYGYKMRLKAYPNGYGDGKGTHLSLSIRIMKGEYDAILEWPFRRKITLSLINQ-------SEQWRSETVE 434

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO35237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM27])

HSP 1 Score: 105.145 bits (261), Expect = 3.610e-24
Identity = 95/380 (25.00%), Postives = 159/380 (41.84%), Query Frame = 2

Query:  374 KNVLAIKVKCPEKACDTKAELKNLMEHLKSHS---INCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKD-------ISLLKNVSKIEKGTTAELPTDSIQINQDGTI------------------CDFTEEESVHYTE-SETDSHFSGTRRSRFMSATSSLRCISANEDI-----------APFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAIL 1393
            K   A  ++CP +    + E K L  H +       +C F  +GC++  VK  A+ +H  +    H ILL  +    +  +  L   L+R +      + +L     +H  E A MK+        + +++     +KG  AE+     Q N  G +                  C  +  + +   + S+T+ +    R S+  S+ +  +     ED+             F WKI+ F  R  EAKS  +  IYS PFY+HR GYKL  R+ PNG G   + +LS+F +++ GE+D  L WP +  + I L+DQ  N + +S+ +        FQ    +P+    +A     G P       L   G + +N   +
Sbjct:  154 KKCPAFPIECPNECGVKRIERKKLSAHTRECPNALTDCRFSPLGCTY-KVKKIALREHQNKHVIKHMILLGRTTGEPQPNLLELENQLERFDGENTSFKTELE----RHKYEFAQMKERFNDQNARLGIVEKTVANQKGDIAEIWMRFDQENLVGEVRMRDKLKKFKVKTKANKECLLSLMKRLEVQDDSQTNPNKLNRRLSQLESSITIHKTKLFQEDLRIQIQQAISYDGTFLWKIDKFTERYAEAKSGNATSIYSSPFYTHRFGYKLCARLFPNGDGSARDNYLSIFIALMRGEYDSILPWPFQETITITLIDQ-DNGMNISETFDPDPCSISFQ----RPTRNINVAS----GCPRFCSQTVLRTRGYMNENCVFV 519

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO31690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX76])

HSP 1 Score: 88.5817 bits (218), Expect = 4.027e-19
Identity = 104/433 (24.02%), Postives = 179/433 (41.34%), Query Frame = 2

Query:  158 QVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKS---HSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLME--SIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKE--IAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQD---GTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISAN--EDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRL----RVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSI 1408
            Q +T    +L+C IC  ++N+P  + CG  +C  C  K  ++G      P D  + +     N    D    + VL++ VKC    C  K EL++  +HL       I C F   GC  + +   +M +H  EE+    I+  E   +   K E E                       T++H  +  +AI+    S +    +  +        +++Q + D   GTI D  +E   +  +   ++    T      +A  ++R +     + I  F W+I D+ +   E        IYS  FY+ + GYK++L    R NP   G    THLS++  I+ GE+D  L WP  R++ + ++DQ   +   +       V  D +  FH+P T   +     YG    + L  L  +G  +K+G +  +  +
Sbjct:   16 QFETPPSPELMCGICLMVVNKPVLTYCGHSFCNFCFNK-WRNGKDVVTCPVDYKQLE----TNQFMADKKTERQVLSLCVKCMNGPCSWKGELRDKKKHLTKCGHEVIKCVFD--GCD-TRLARNSMEKH--EETCEWKIVTCEFCDVPYPKREEE-----------------------TVKHRGDCPLAILPCKFSDIGCTFEGRQHAHVAHCENAVQAHLDMACGTIRDNNKEIRKNNKKIRGNNKEIETLHKELNTANQTIRELKGKMAKLIGTFVWRICDYKDLYGE--------IYSPSFYTSKYGYKVQLKANLRTNPFNGG----THLSLYACIMVGEYDALLEWPFRRKITLYVIDQSDQRKHETLLINPDDVLPDRKKCFHRPITGNNVG----YGLTRFLSLEEL-TSGGFIKDGVMFIKAVV 398

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48773 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI91])

HSP 1 Score: 88.5817 bits (218), Expect = 8.461e-19
Identity = 102/506 (20.16%), Postives = 179/506 (35.38%), Query Frame = 2

Query:  134 QLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGN-----------------------------------------------------KYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSI------------------------NCPFHEMGCSHSNVKS-QAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVS--KIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +L   YD   D  L S   C IC   L  P Q+PCG R+C++CI + ++                                                        K CP    +C  +C  +    + D    +      V C    C  K  +  + EHLK                             CP   + C H  +KS +    H  +E   H          ++ E      N+QR+   +G   ++ R       + +A +++ +  +K  S  +I + T   +  ++ +I  +G +C+ T                                          F WK+++F    + + + L+  I+S PFY+   GYK+ LR+N NG       H+S+F  +++G++D  L WP   ++ + ++DQ S++I          V K   + F +P   T   ++  YG      ++ L   G+ +KN +IL R  I+
Sbjct:   39 RLEEGYDEFFDPPLESKYECPICLLGLRDPVQTPCGHRFCFNCIRRSIRDAGPKCPVDNTPLSERELYRDNFAKREMMSFIVWCRLKKERGCTWKGALKELEEHLKGCPCMDTNCPNECGAVMQRKEVDKHCAEACPNRSVPC--DHCKMKVTISKIEEHLKGCPCMDTNCPNECGAVMQRKEVDKHCAEACPNRSVPCDHCKMKSSKEQASHGPQEHTPHEA-------ELRREALFQSANMQREVDMLGSRGDEYR-------QFLAYLERKVEDVKTSSDRRIAELTHKLMRLETREIELEGRVCNGT------------------------------------------FIWKLDNFRQCREGSIAGLTAAIHSPPFYTSMYGYKMCLRMNLNGVDGGLGEHVSLFIHMMQGDWDGILEWPFIGRITLSILDQ-SDQIDSRRPISETLVAKPNLLAFQRP---TSPRNHKGYGYVEFCPIDQL-TEGQYIKNNSILVRIQIS 481

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf3 (TNF receptor associated factor 3 [Source:NCBI gene;Acc:101161601])

HSP 1 Score: 121.324 bits (303), Expect = 1.901e-29
Identity = 98/425 (23.06%), Postives = 183/425 (43.06%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKA--CDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGK-----LQNQLRNNTLQHNKEI-----------AIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            C  C  +L +P Q+ CG R+CYSCI   L   N  CP   +          + +  D   ++ ++A+KV C  +A  C  +  L+ + +H+      CPF E+ C     K + M + + E           + +  KN++ +    LQ+ ++T+         N   +++L  ++++            +  + +  L++  +  +GT   + T    + Q G         S+    +  D   S     R        + +          WKI D+  R Q+A +  +  +YS+PFY+   GYK+  RV  NG G  + THLS+FF ++ GE+D  L WP +++V + L+DQ  ++  + D ++       F+    +P     IA     G P  +   S+  +G  +K+  I  + +++
Sbjct:   48 CEACRLVLCQPRQTECGHRFCYSCINDILSCPNPVCPADMEPL------FKDKIFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIPDHVNV----CPFFEVPCPLGKCKERMMRKEIPEHLAWKCKYRESTCEFCKNKMPL--TELQKHKETVCPAFPVSCPNHCTSSSLPRSEKLMSSHTEKLLELELELRSLRQLRDEMESLRGTLDTVRTRLSALEQGG-------RASLETQLNRHDDMLS-VHEIRLADMDLRFQVLETASYNGTLIWKIRDYKRRKQDAVAGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQGPSRKHLGDAFKPDPSSSSFR----RPVAEMNIAS----GCPLFVS-QSVLESGTYIKDDTIFIKVTVD 443

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 90.8929 bits (224), Expect = 3.746e-19
Identity = 81/323 (25.08%), Postives = 140/323 (43.34%), Query Frame = 2

Query:  476 CPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNM-KNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDI----------APFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            CPF E+GC  S V++  + +H    +  H  LL+  + +M +  ++       +++  +G  +          +     + K +S L+N+  +      E+   S+      T+  F+ +   H  + E   + S   R    S T     +S  E +            F WKI DF +R QEA S  +  ++S  FYS + GYK+ LR+  NG G    THLS+FF ++  ++D  L WP  ++V + L+DQ +N+  + D +R       FQ    +P +   IA     G P    L  L      L++  I  +  ++
Sbjct:  212 CPFSEVGCK-SVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDTSPSGEWQEDSGLGLYRAPDDGCGAAASVPSVDLDKKVSALENIVCV---LNREVERSSL------TLEAFSHQ---HRLDQEKIENLSNKIRQLERSLTVKDLQLSEAEQMVRELQYCTYDGIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ-NNREHIIDAFRPDITSTSFQ----RPVSEMNIAS----GCPLFCPLAKLAGKSPYLRDDTIFIKAIVD 512

HSP 2 Score: 51.2174 bits (121), Expect = 2.002e-6
Identity = 31/110 (28.18%), Postives = 52/110 (47.27%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCR-----EQCVDINNNLQF--DHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGC 499
            C  C ++L +P Q+ CG R+C  C  +   SG    PKP   CR     E+ + I N+ +   D+ A + + ++  +C  + CD    +K   E+   H   C F ++ C
Sbjct:   30 CQQCLQVLRKPVQAQCGHRFCVHCFRQLTSSG----PKPCQACRKEEIYEEPMSILNSSEAFPDNAAGREIASLPARCLNQGCDWTGSIK---EYEAKHEGRCEFEQIQC 132

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 90.8929 bits (224), Expect = 4.394e-19
Identity = 80/323 (24.77%), Postives = 139/323 (43.03%), Query Frame = 2

Query:  476 CPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNM-KNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDI----------APFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            CPF E+GC  S V++  + +H    +  H  LL+  + +M +  ++       +++  +G  +          +     + K +S L+N+  +      E+   S+ +        F+ +   H  + E   + S   R    S T     +S  E +            F WKI DF +R QEA S  +  ++S  FYS + GYK+ LR+  NG G    THLS+FF ++  ++D  L WP  ++V + L+DQ +N+  + D +R       FQ    +P +   IA     G P    L  L      L++  I  +  ++
Sbjct:  219 CPFSEVGCK-SVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDTSPSGEWQEDSGLGLYRAPDDGCGAAASVPSVDLDKKVSALENIVCV---LNREVERSSLTLEA------FSHQ---HRLDQEKIENLSNKIRQLERSLTVKDLQLSEAEQMVRELQYCTYDGIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLNGDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ-NNREHIIDAFRPDITSTSFQ----RPVSEMNIAS----GCPLFCPLAKLAGKSPYLRDDTIFIKAIVD 519

HSP 2 Score: 51.2174 bits (121), Expect = 1.740e-6
Identity = 31/110 (28.18%), Postives = 52/110 (47.27%), Query Frame = 2

Query:  191 CTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCR-----EQCVDINNNLQF--DHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGC 499
            C  C ++L +P Q+ CG R+C  C  +   SG    PKP   CR     E+ + I N+ +   D+ A + + ++  +C  + CD    +K   E+   H   C F ++ C
Sbjct:   37 CQQCLQVLRKPVQAQCGHRFCVHCFRQLTSSG----PKPCQACRKEEIYEEPMSILNSSEAFPDNAAGREIASLPARCLNQGCDWTGSIK---EYEAKHEGRCEFEQIQC 139

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: ENSORLT00000020861.2 (TNF receptor-associated factor 2 [Source:NCBI gene;Acc:101167626])

HSP 1 Score: 89.3521 bits (220), Expect = 1.788e-18
Identity = 97/408 (23.77%), Postives = 171/408 (41.91%), Query Frame = 2

Query:  365 FANKNVLAIKVKCP------EKACDTKAELKNLMEHLKSHS---INCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILR-ENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNV-------------SKIEKGTTAELPTDSIQINQDGTICDFTE-----------------EESVHYTESETDSHFSG-------TRRSRFMSATSSLRCISANE------DIAP------FEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            F  KN+ A    CP      E     K   +  ++H+K  S     C FH +GC  ++V+ + +  H  + SY H  LL+  I  +K  +E L+ + L+   + + +L   LR+  L+ ++   + +   + L+ V             S +      +L ++  ++ +    C   E                 E S    E+    H          + + R +  T SLR +S  E      D++       F WKI DF  + Q+A +  +  ++S  FY+ + GYK+ LR+  NG G    THLS+FF ++ G  D  L WP  ++V + L+DQ +N+  + D +R       FQ    +P +   IA     G P    L+ L +    +++  I  +  ++
Sbjct:  171 FLLKNIKAHDEICPKYPMMCEGCAKKKIPREKYVDHIKFCSKFKAPCRFHVVGCD-TSVEKEKIHDHERQCSYEHLNLLLHFIMGIKVSLESLQPQRLEVASQKLHELHQSLRDLELRMSQ---LGRSGTAPLQGVCAATLATSFTPLHSAMGAALELQLQSEKTKVAELSRRCQELELKVSTFENIVCILNRELERSCATMEAYNRQHRLDQDKIEILSNKVRQLERTVSLRDLSIVEMEGKMKDMSAATYDGIFIWKISDFTKKRQDAMAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ-NNREHIIDAFRPDISSSSFQ----RPVSDMNIAS----GCPLFCPLSKLDSKNSYIRDETIFIKAIVD 565

HSP 2 Score: 51.2174 bits (121), Expect = 1.900e-6
Identity = 34/107 (31.78%), Postives = 50/107 (46.73%), Query Frame = 2

Query:  188 ICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPT-DDCREQCVDI--NNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGC 499
            +C  CEKIL RP Q+ CG R+C  C  + + SG + C     +D  E+   I        D+ A + V A+   CP + C     +K   E+  SH  +C F  + C
Sbjct:   34 LCNSCEKILRRPLQAQCGHRFCCFCFNRTVSSGPQKCSACIKEDLFEEPTSILKQGGAFHDNAARREVEALAAVCPNEGCTWTGTVK---EYEASHEGSCDFTIIMC 137

[Close]

BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 87.8113 bits (216), Expect = 3.918e-18
Identity = 101/441 (22.90%), Postives = 182/441 (41.27%), Query Frame = 2

Query:  191 CTICEKILNRPYQ-SPCGCRYCYSCIEKHLKSGNKYCPK-----------PTDDCREQ-------CVDINNNLQF--------DHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCS--HSNVKSQAMVQHMT----EESYSHTILLMESIQNMKNEIEILRENLQRKE--KTIGK--LQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVH---------YTESETDSHFS------GTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQ----VSNKIQVSDKYRWKSVEKDFQVIFHKP-STRTEIADYYF-YGTPTLI 1339
            C +C K +  P Q S CG R+C +C+++ L  G   CP+           P  +  +Q       C+      ++         HF+      I   CP + C  K   ++L +HL+    +CP  ++ C    S    +A   H      E  Y         ++ + ++   + E  +R +  K  GK  + + ++N+   H     +   +     N+++ +     +    S  +     +C F +    H         + E  T SH +        +R   +     +  +S + D     WK+ D+  ++QEAK + +   +S PFY+HR GYKL++    NG G  E +HLSV+  ++ GE+D+ L WP   +V   ++DQ    +S    +++ +      K+FQ    KP STR  + +    +G P  I
Sbjct:   18 CPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIP--CPNR-CSVKLTRRDLPDHLQH---DCPKRKVKCEFCGSEFTGEAFENHQGVCPQESVYCENKCGARMMRRLLSQ-HGMAECPKRTQPCKYCGKEFVFDTIQNHQF-HCPRFPVQCPNQCGTPNIAREDLANHVKDNCGSALV-----LCPFKDAGCKHRCPKLAIGRHLEDTTKSHLTMMCNLVSRQRQEILELRREMEELSVSHDGV-LIWKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDPNWKNFQ----KPCSTRNSLDESTLGFGYPKFI 440

[Close]

BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070236.1 (SMESG000070236.1)

HSP 1 Score: 912.524 bits (2357), Expect = 0.000e+0
Identity = 436/436 (100.00%), Postives = 436/436 (100.00%), Query Frame = 2

Query:  104 MANSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            MANSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN
Sbjct:    1 MANSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 436

[Close]

BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070235.1 (SMESG000070235.1)

HSP 1 Score: 306.605 bits (784), Expect = 1.521e-103
Identity = 144/145 (99.31%), Postives = 144/145 (99.31%), Query Frame = 2

Query:  977 MNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            MNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFY TPTLIHLNSLFNNGKLLKNGAILFRCSIN
Sbjct:    1 MNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYSTPTLIHLNSLFNNGKLLKNGAILFRCSIN 145

[Close]

BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070155.1 (SMESG000070155.1)

HSP 1 Score: 295.434 bits (755), Expect = 2.130e-95
Identity = 165/430 (38.37%), Postives = 251/430 (58.37%), Query Frame = 2

Query:  122 QEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            +E + LL  +DF  D+ L  DL+C+IC+ IL+   Q+ CGCRYCY CIEK+L    K+CPK   +C+ + ++ N ++  DHFANK +L+IKVKCPE  C     L  + +H+KSHSI CP+ E+GC  S + +  +  H+T E+YSHT LL+ESI+N+ NEI  L+EN  R ++ I  LQ  + N  LQ+  EI +    I+++K   K  +    EL  DS Q N+   I +   + S        +      +R + +   +    ++  +  APFEWKIE+    + ++K    +  YS+ FYSH NGYK+RL ++P G+   E  HL V+F ++ GE+DD L WPM + V IGLVDQ+   I V + ++  S+++ F+  F +PS R+   D   Y    LI+L  L NN KL+ +G+I  +C ++
Sbjct:    7 EEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCK-KLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQ--IENIELQN--EINM----INIVKMEMKTLQDGMKELKNDSQQKNK--LIYEMMRKNS--------NEQILIEKRLKSLEEINEGN-LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRS--PDDIDYCQSVLINLKVLLNNPKLVMDGSIFLKCFVD 414

[Close]

BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000067196.1 (SMESG000067196.1)

HSP 1 Score: 294.664 bits (753), Expect = 6.678e-95
Identity = 156/442 (35.29%), Postives = 248/442 (56.11%), Query Frame = 2

Query:  104 MANSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKL-------QNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSI 1408
            MAN+K+ +I++L   Y+F++D   Y DLIC IC KILN   QS CGCRYCYSCI  +L    K CP+ ++DC+   ++  N+LQ DH ANK +  I+V+CPE  C  K EL+ + EH++ H   CP+H +GC  +N  SQA+ QH+ E+  SH  +L E I+ MK E + L   +   E  + +L       + QL +     N+ I+ MK    +L+     ++    E+  + +++     + +  ++ S  Y E       +G   SR  S  +      A +  +P+ W + DF+ +   A++ +   I S  F S   GY +RL + PNG+G  EN ++SV F ++EG+FD  L WPM++++ I L+DQ S    + +K+ + + EK  + IFHKPS+R   ++ Y YG    I ++SL +N +L KNG+IL +C +
Sbjct:    1 MANNKYDDIWELFDKYNFEIDYKTYKDLICIICNKILNNSTQSSCGCRYCYSCISTYLNGEEKCCPRDSEDCKNHLINSQNDLQIDHAANKIISKIEVQCPEPQCQVKTELQKMSEHIQRHKFQCPYHTIGCQINNSNSQALKQHLIED--SHATMLSEFIEIMKTENKKLNAMVSITEARVDELTVMNVDMKQQLIDVKNGENEIISKMK----ILEEDGHYKQNIINEIMEEIVKL--QSHLKNLEQKISTKYPEE------NGNTLSRRTSKLTLTPPTVAMQQFSPYSWTVGDFLAKWDSARNGIETFINSDIFLSKEMGYGIRLSLYPNGYGSAENNYVSVLFGLMEGQFDHKLAWPMKQEITIALIDQQSGSFHIHEKFSYGATEKQSKYIFHKPSSRYTNSN-YMYGAAKFIKIDSLISNNRLFKNGSILLKCFV 427

[Close]

BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070096.1 (SMESG000070096.1)

HSP 1 Score: 277.33 bits (708), Expect = 7.739e-88
Identity = 161/462 (34.85%), Postives = 262/462 (56.71%), Query Frame = 2

Query:  113 SKFQEIYQLLTDYDFQVD-TFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQA---MVQHMTEESYSHTILLMESIQNMKNEIEILR----------ENLQRKEKTIGKLQNQLRNNTL-QHNKEIAIMKK-------DISLLKN-VSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTE------SETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEIADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN 1411
            SK++E++ L   Y+F+++    ++DL C +C+ +L    QSPCGCRYC+SCI  +L    K CP P DDC+ Q ++I+ ++  DH AN+ +  + VKCPE++C+ + +L+ + EH+ SH ++CP+ ++GC   N+K +    +V HM +   SH  LL++ + N+KN+IE L+          EN+           N ++ +TL Q +++I+ +K        DI  L++ + ++     +E+   ++++ +          E V Y        S TDS  S    +   S           E IAPFEWKI +FM + + A S     +YS+PFYSH+NGYK++LR++PNG    +  +LSV F II GE+DD L WPM +QV I L++Q +  + +S +Y++ SV K  + IF KP +R E  + YF+GT   I  + LFNN K+  N +I+ +C I+
Sbjct:    3 SKYEEMWNLFNKYNFKLNLNSKFADLKCCVCQGLLRNASQSPCGCRYCHSCIVVYLGDEEKCCPGPHDDCKYQRINIHKDITIDHAANRKISMVDVKCPEESCNARIQLRQMPEHITSHILSCPYLDIGC---NIKLRGVCELVDHMLDADQSHASLLIQCLNNIKNDIEYLKGSDSASFSSSENINAINYDAISQINNIKLSTLPQISQKISKLKSETAQRGNDIGRLESQIEEVNSNCMSEIKILTLEMER-------LRNELVAYKIGKDLDISTTDSMLSSADSNSTSSFILK----QVKEHIAPFEWKITNFMEKHERAISGEKLTVYSEPFYSHKNGYKIQLRIDPNGDEAVKALYLSVSFGIIGGEYDDELDWPMTKQVKISLINQKTGLVHISKRYKFDSVLKKSKCIFFKPISRFEDDEDYFFGTLKFIKFSVLFNNQKIFLNDSIVLKCFID 450

The following BLAST results are available for this feature:

BLAST of TNF receptor-associated factor vs. Ensembl Human
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
BLAST of TNF receptor-associated factor vs. Ensembl Fly
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
BLAST of TNF receptor-associated factor vs. TrEMBL
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
BLAST of TNF receptor-associated factor vs. Ensembl Yeast
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
BLAST of TNF receptor-associated factor vs. Planmine SMEST

BLAST of TNF receptor-associated factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TRAF3	2.932e-29	23.88	TNF receptor associated factor 3 [Source:HGNC Symb...	[more]
TRAF3	4.585e-25	22.20	TNF receptor associated factor 3 [Source:HGNC Symb...	[more]
TRAF3	4.585e-25	22.20	TNF receptor associated factor 3 [Source:HGNC Symb...	[more]
TRAF6	3.632e-24	23.24	TNF receptor associated factor 6 [Source:HGNC Symb...	[more]
TRAF6	3.632e-24	23.24	TNF receptor associated factor 6 [Source:HGNC Symb...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
trf-1	1.505e-14	33.33	TNF Receptor Associated Factor (TRAF) homolog; TRF...	[more]
trf-2	5.160e-9	39.44	TNF Receptor Associated Factor (TRAF) homolog [So...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Traf4	9.180e-15	28.76	gene:FBgn0026319 transcript:FBtr0334401	[more]
Traf4	1.222e-14	28.76	gene:FBgn0026319 transcript:FBtr0077429	[more]
Traf-like	2.123e-9	30.77	gene:FBgn0030748 transcript:FBtr0074275	[more]
Traf-like	3.261e-9	30.77	gene:FBgn0030748 transcript:FBtr0074273	[more]
Traf-like	3.434e-9	30.77	gene:FBgn0030748 transcript:FBtr0308606	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
traf6	1.224e-29	23.20	TNF receptor-associated factor 6 [Source:NCBI gene...	[more]
traf6	1.224e-29	23.20	TNF receptor-associated factor 6 [Source:NCBI gene...	[more]
traf6	1.224e-29	23.20	TNF receptor-associated factor 6 [Source:NCBI gene...	[more]
traf4a	2.534e-22	23.01	tnf receptor-associated factor 4a [Source:ZFIN;Acc...	[more]
traf4a	2.534e-22	23.01	tnf receptor-associated factor 4a [Source:ZFIN;Acc...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ssh2	1.366e-23	22.42	slingshot protein phosphatase 2 [Source:Xenbase;Ac...	[more]
ssh2	3.241e-21	23.44	slingshot protein phosphatase 2 [Source:Xenbase;Ac...	[more]
egf	2.596e-20	22.75	epidermal growth factor [Source:Xenbase;Acc:XB-GEN...	[more]
slc12a1	7.150e-19	23.43	solute carrier family 12 member 1 [Source:Xenbase;...	[more]
slc12a1	3.653e-18	24.00	solute carrier family 12 member 1 [Source:Xenbase;...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Traf6	1.323e-28	23.67	TNF receptor-associated factor 6 [Source:MGI Symbo...	[more]
Traf3	1.352e-25	22.40	TNF receptor-associated factor 3 [Source:MGI Symbo...	[more]
Traf3	1.352e-25	22.40	TNF receptor-associated factor 3 [Source:MGI Symbo...	[more]
Traf3	1.655e-23	23.08	TNF receptor-associated factor 3 [Source:MGI Symbo...	[more]
Traf2	5.729e-20	25.75	TNF receptor-associated factor 2 [Source:MGI Symbo...	[more]

BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6IWL4\|TRAF6_DANRE	9.240e-29	23.20	TNF receptor-associated factor 6 OS=Danio rerio OX...	[more]
sp\|P70196\|TRAF6_MOUSE	9.252e-28	23.67	TNF receptor-associated factor 6 OS=Mus musculus O...	[more]
sp\|B5DF45\|TRAF6_RAT	6.402e-27	24.38	TNF receptor-associated factor 6 OS=Rattus norvegi...	[more]
sp\|B6CJY4\|TRAF6_CERAT	4.885e-24	23.44	TNF receptor-associated factor 6 OS=Cercocebus aty...	[more]
sp\|B6CJY5\|TRAF6_MACMU	5.068e-24	23.44	TNF receptor-associated factor 6 OS=Macaca mulatta...	[more]

BLAST of TNF receptor-associated factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0F7GY08	3.695e-35	47.26	TNF receptor associated factor 5 (Fragment) OS=Sch...	[more]
T1E101	1.979e-34	26.14	TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1	[more]
I1ZID8	1.409e-29	30.77	TNF receptor associated factor-2 (Fragment) OS=Sch...	[more]
A0A498M8A6	3.135e-29	24.30	TNF receptor-associated factor OS=Labeo rohita OX=...	[more]
A0A553RF85	1.066e-28	25.79	TNF receptor-associated factor OS=Danionella trans...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
traf6	6.799e-29	24.19	TNF receptor associated factor 6 [Source:NCBI gene...	[more]
traf6	1.216e-26	23.82	TNF receptor associated factor 6 [Source:NCBI gene...	[more]
traf6	1.216e-26	23.82	TNF receptor associated factor 6 [Source:NCBI gene...	[more]
traf4a	1.380e-22	22.13	TNF receptor associated factor 4 [Source:NCBI gene...	[more]
ENSAMXT00000035169.1	1.260e-19	31.13	pep primary_assembly:Astyanax_mexicanus-2.0:9:3354...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000000074.1	1.720e-23	23.84	pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-...	[more]
ENSPMAT00000002130.1	1.083e-22	23.44	pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 g...	[more]
traf6	1.316e-11	31.09	TNF receptor-associated factor 6 [Source:NCBI gene...	[more]
ENSPMAT00000008091.1	4.737e-7	34.21	pep scaffold:Pmarinus_7.0:GL477915:34322:50582:-1 ...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49464	5.911e-27	23.03	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48394	5.678e-26	25.11	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35237	3.610e-24	25.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31690	4.027e-19	24.02	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48773	8.461e-19	20.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
traf3	1.901e-29	23.06	TNF receptor associated factor 3 [Source:NCBI gene...	[more]
traf2b	3.746e-19	25.08	TNF receptor associated factor 2 [Source:NCBI gene...	[more]
traf2b	4.394e-19	24.77	TNF receptor associated factor 2 [Source:NCBI gene...	[more]
ENSORLT00000020861.2	1.788e-18	23.77	TNF receptor-associated factor 2 [Source:NCBI gene...	[more]
traf4a	3.918e-18	22.90	TNF receptor associated factor 4 [Source:NCBI gene...	[more]

BLAST of TNF receptor-associated factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000070236.1	0.000e+0	100.00	SMESG000070236.1	[more]
SMESG000070235.1	1.521e-103	99.31	SMESG000070235.1	[more]
SMESG000070155.1	2.130e-95	38.37	SMESG000070155.1	[more]
SMESG000067196.1	6.678e-95	35.29	SMESG000067196.1	[more]
SMESG000070096.1	7.739e-88	34.85	SMESG000070096.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027110 ID=SMED30027110|Name=TNF receptor-associated factor|organism=Schmidtea mediterranea sexual|type=transcript|length=1501bp
AAATATTAGTAAATTCAATATTATTCTTGGAATTATTTTAATATAATCGC
GTCAGTATTTATTTATTGGAACTTTTATCAAATTCATATGCAATAATTGC
TCAATGGCTAATTCAAAATTTCAAGAAATTTACCAACTCTTAACCGATTA
CGATTTCCAGGTCGACACTTTCTTGTATTCTGATTTGATATGCACAATAT
GTGAGAAAATTCTCAATAGGCCGTATCAAAGCCCATGCGGTTGCAGATAC
TGTTATTCATGTATTGAAAAGCATCTAAAGAGCGGAAACAAGTACTGCCC
CAAGCCGACTGACGACTGTCGGGAACAATGTGTTGACATCAATAATAATT
TACAATTTGATCATTTCGCCAATAAAAATGTATTGGCAATTAAAGTGAAA
TGCCCGGAAAAAGCATGCGACACTAAAGCCGAGTTAAAGAATTTAATGGA
ACACTTGAAATCCCATAGCATCAATTGCCCATTCCATGAAATGGGATGCA
GTCACTCGAATGTCAAGAGTCAGGCCATGGTACAACACATGACGGAGGAA
AGCTATTCACACACGATATTATTAATGGAGTCTATTCAAAACATGAAAAA
TGAAATTGAAATACTCCGAGAGAATTTACAAAGAAAAGAAAAAACTATTG
GAAAATTACAAAATCAACTGAGGAACAATACACTTCAACACAACAAGGAG
ATTGCCATAATGAAAAAGGATATTTCATTGCTAAAAAATGTGTCAAAAAT
CGAAAAGGGAACTACTGCTGAATTGCCAACAGATTCCATTCAAATAAATC
AAGATGGAACAATTTGTGACTTTACAGAGGAAGAAAGCGTTCATTATACG
GAATCAGAAACAGACTCCCATTTCAGTGGAACAAGGCGAAGTCGGTTTAT
GTCTGCTACAAGTTCTCTTAGATGTATATCAGCAAATGAAGACATTGCAC
CTTTCGAATGGAAAATCGAAGATTTTATGAATCGTGTCCAAGAAGCTAAA
TCGAAACTGAGTAAAGTTATTTACAGCAAACCGTTTTATTCCCATAGAAA
CGGTTATAAATTACGGTTACGCGTCAATCCGAACGGATTCGGAAAATGGG
AAAATACCCATCTGTCGGTTTTTTTCAGTATCATTGAAGGTGAATTCGAC
GATTCGCTATTTTGGCCGATGGAACGACAAGTGGTAATCGGATTAGTGGA
TCAAGTTTCAAATAAAATTCAAGTCAGTGATAAATACAGATGGAAATCTG
TTGAAAAGGACTTCCAAGTAATCTTTCACAAACCCTCAACGAGAACTGAA
ATTGCAGATTATTATTTCTACGGTACCCCCACACTTATACACCTTAATTC
CTTATTTAACAATGGTAAACTATTGAAAAACGGCGCCATTCTCTTTAGGT
GTTCCATTAATTGAGCTCATCTATTTTATCATTCAAATTTCAACTATTTA
TTGGTGTTTATTATCTTTCATTTCTGCGTCATTTAGATTGTTATTGCGTA
A

protein sequence of SMED30027110-orf-1

>SMED30027110-orf-1 ID=SMED30027110-orf-1|Name=SMED30027110-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=437bp
MANSKFQEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYC
YSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKC
PEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEES
YSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEI
AIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTE
SETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKS
KLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDD
SLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRTEI
ADYYFYGTPTLIHLNSLFNNGKLLKNGAILFRCSIN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm
GO:0005622	intracellular

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0046330	positive regulation of JNK cascade

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0000101	muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR043211	TNF_rcpt-assoc_TRAF
IPR002083	MATH/TRAF_dom
IPR008974	TRAF-like
IPR013083	Znf_RING/FYVE/PHD
IPR001841	Znf_RING

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 158..195
None	No IPR available	PANTHER	PTHR10131:SF129	TNF RECEPTOR-ASSOCIATED FACTOR 6	coord: 121..435
None	No IPR available	PANTHER	PTHR10131:SF129	TNF RECEPTOR-ASSOCIATED FACTOR 6	coord: 11..120
None	No IPR available	CDD	cd16449	RING-HC	coord: 30..66 e-value: 5.31222E-9 score: 49.3881
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 24..90
IPR002083	MATH/TRAF domain	SMART	SM00061	math_3	coord: 286..417 e-value: 0.0044 score: 26.2
IPR002083	MATH/TRAF domain	PROSITE	PS50144	MATH	coord: 281..435 score: 15.149
IPR008974	TRAF-like	GENE3D	G3DSA:2.60.210.10		coord: 248..436 e-value: 1.0E-38 score: 134.7
IPR008974	TRAF-like	SUPERFAMILY	SSF49599	TRAF domain-like	coord: 284..435
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 12..138 e-value: 1.4E-17 score: 65.7
IPR043211	TNF receptor-associated factor TRAF	PANTHER	PTHR10131	TNF RECEPTOR ASSOCIATED FACTOR	coord: 121..435
IPR043211	TNF receptor-associated factor TRAF	PANTHER	PTHR10131	TNF RECEPTOR ASSOCIATED FACTOR	coord: 11..120
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 30..66 score: 9.465

Main menu

TNF receptor-associated factor

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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