GATA zinc finger domain-containing protein 1

Overview


Name	GATA zinc finger domain-containing protein 1
Smed ID	SMED30027077
Length (bp)	673

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of GATA zinc finger domain-containing protein 1 (SMED30027077) t-SNE clustered cells

Violin plots show distribution of expression levels for GATA zinc finger domain-containing protein 1 (SMED30027077) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GATA zinc finger domain-containing protein 1 (SMED30027077) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027077

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30027077	SMESG000039949.1 SMESG000039948.1	dd_Smed_v4_9074_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30027077	SMESG000039949.1 SMESG000039948.1	dd_Smed_v4_9074_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30027077	SMESG000039949.1 SMESG000039948.1	dd_Smed_v6_9074_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Human
Match: GATAD1 (GATA zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29941])

HSP 1 Score: 85.1149 bits (209), Expect = 3.015e-19
Identity = 44/125 (35.20%), Postives = 65/125 (52.00%), Query Frame = 1

Query:  232 KSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVS-FEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            K K RR I K   PIK       +     +F +G+ Y IGD+VS  ++ +G  YYAQIR        +K   +TWL+P      + F+P+ +I+G EED  R + +  FV   PS+YF    +P+
Sbjct:  113 KGKGRRHIFKLKNPIKAPESVSTIITAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLSSPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPF 237

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Fly
Match: CG13367 (gene:FBgn0025634 transcript:FBtr0070121)

HSP 1 Score: 73.9442 bits (180), Expect = 3.520e-15
Identity = 41/125 (32.80%), Postives = 66/125 (52.80%), Query Frame = 1

Query:  238 KSRRAILKRNPPIKYVPE-RRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEEC--DTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            ++RRA+ K+  P +  P+ +        LF +G    IGDIVS  D    +YYAQIR L   +  +K   +TWL+P ++     E F+P  +++G +E+  R L +  FV   PS+Y+     P+
Sbjct:  248 RNRRALFKK--PAQKTPKVQASTRFVRSLFHKGSYIQIGDIVSIVDSEQNLYYAQIRGLLVDAYCEKSAFLTWLIPTQDSPDPQEGFDPPTYLIGPDEELSRKLCYLEFVMHAPSNYYFDRSTPF 370

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Zebrafish
Match: gatad1 (GATA zinc finger domain containing 1 [Source:NCBI gene;Acc:678617])

HSP 1 Score: 86.2705 bits (212), Expect = 3.636e-20
Identity = 55/150 (36.67%), Postives = 77/150 (51.33%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESK-LFCEGIMYNIGDIVSFEDMN-GGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            R+S R R  STK +      +   K K RR I K   PIK  PE     + S+ +F +GI Y IGD++   D + G  YYAQIR        +K   +TWL+P +    + F+PS +I+G EED  R + +  FV   PS+YF     P+
Sbjct:   67 RRSARLR--STKYKAPASEKKVSTKGKGRRHIFKLKNPIK-APESVSTIITSESMFYKGIYYQIGDVIKVIDEDDGKPYYAQIRGFVQDQYCEKSAALTWLIPTQASPRDRFDPSTYIVGPEEDLPRKMEYLEFVCHAPSEYFKSRSCPF 213

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Xenopus
Match: gatad1 (uncharacterized LOC100127267 [Source:Xenbase;Acc:XB-GENE-5844016])

HSP 1 Score: 84.7297 bits (208), Expect = 3.205e-19
Identity = 51/149 (34.23%), Postives = 72/149 (48.32%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDM-NGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            R+S R R    K  T  +  +   K K RR I K   PIK       +     +F +G+ Y IGD+VS  D  +G  YYAQIR        +K   +TWL+P      + F+PS +I+G +ED  R +    FV   PS+YF    +P+
Sbjct:   90 RRSARLRNTKYK-STPAVEKKVSTKGKGRRHIFKLKNPIKAPEAVSTIVTSESIFHKGLYYQIGDVVSVVDEEDGKTYYAQIRGFVQDQYCEKSAALTWLIPTMSSPKDGFDPSTYIIGPDEDLPRKMECLEFVCHAPSEYFKSRSSPF 237

[Close]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Xenopus
Match: gatad1 (uncharacterized LOC100127267 [Source:Xenbase;Acc:XB-GENE-5844016])

HSP 1 Score: 72.4034 bits (176), Expect = 8.607e-15
Identity = 46/149 (30.87%), Postives = 71/149 (47.65%), Query Frame = 1

Query:  181 TISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPE-RRKMELESK------LFCEGIMYNIGDIVSFEDM-NGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            + ST  ++N  + +   +   RR+   RN   K  P   +K+  + K          G+ Y IGD+VS  D  +G  YYAQIR        +K   +TWL+P      + F+PS +I+G +ED  R +    FV   PS+YF    +P+
Sbjct:   69 SASTSQQSNGGNTKQSKQEIHRRSARLRNTKYKSTPAVEKKVSTKGKGRRHIFKLKNGLYYQIGDVVSVVDEEDGKTYYAQIRGFVQDQYCEKSAALTWLIPTMSSPKDGFDPSTYIIGPDEDLPRKMECLEFVCHAPSEYFKSRSSPF 217

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Mouse
Match: Gatad1 (GATA zinc finger domain containing 1 [Source:MGI Symbol;Acc:MGI:1914460])

HSP 1 Score: 84.7297 bits (208), Expect = 2.213e-19
Identity = 44/125 (35.20%), Postives = 65/125 (52.00%), Query Frame = 1

Query:  232 KSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVS-FEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            K K RR I K   PIK       +     +F +G+ Y IGD+VS  ++ +G  YYAQIR        +K   +TWL+P      + F+P+ +I+G EED  R + +  FV   PS+YF    +P+
Sbjct:  110 KGKGRRHIFKLKNPIKAPESVSTIVTAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLASPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPF 234

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Mouse
Match: Gatad1 (GATA zinc finger domain containing 1 [Source:MGI Symbol;Acc:MGI:1914460])

HSP 1 Score: 70.4774 bits (171), Expect = 2.117e-14
Identity = 39/111 (35.14%), Postives = 57/111 (51.35%), Query Frame = 1

Query:  232 KSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVS-FEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVS 561
            K K RR I K   PIK       +     +F +G+ Y IGD+VS  ++ +G  YYAQIR        +K   +TWL+P      + F+P+ +I+G    E +HL F +F S
Sbjct:  110 KGKGRRHIFKLKNPIKAPESVSTIVTAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLASPRDQFDPASYIIG----EAQHLRFTSFFS 216

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BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q1L8G7|GATD1_DANRE (GATA zinc finger domain-containing protein 1 OS=Danio rerio OX=7955 GN=gatad1 PE=2 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 2.745e-19
Identity = 55/150 (36.67%), Postives = 77/150 (51.33%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESK-LFCEGIMYNIGDIVSFEDMN-GGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            R+S R R  STK +      +   K K RR I K   PIK  PE     + S+ +F +GI Y IGD++   D + G  YYAQIR        +K   +TWL+P +    + F+PS +I+G EED  R + +  FV   PS+YF     P+
Sbjct:   67 RRSARLR--STKYKAPASEKKVSTKGKGRRHIFKLKNPIK-APESVSTIITSESMFYKGIYYQIGDVIKVIDEDDGKPYYAQIRGFVQDQYCEKSAALTWLIPTQASPRDRFDPSTYIVGPEEDLPRKMEYLEFVCHAPSEYFKSRSCPF 213

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BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q8WUU5|GATD1_HUMAN (GATA zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATAD1 PE=1 SV=1)

HSP 1 Score: 85.1149 bits (209), Expect = 1.448e-18
Identity = 44/125 (35.20%), Postives = 65/125 (52.00%), Query Frame = 1

Query:  232 KSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVS-FEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            K K RR I K   PIK       +     +F +G+ Y IGD+VS  ++ +G  YYAQIR        +K   +TWL+P      + F+P+ +I+G EED  R + +  FV   PS+YF    +P+
Sbjct:  113 KGKGRRHIFKLKNPIKAPESVSTIITAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLSSPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPF 237

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BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q920S3|GATD1_MOUSE (GATA zinc finger domain-containing protein 1 OS=Mus musculus OX=10090 GN=Gatad1 PE=2 SV=2)

HSP 1 Score: 84.7297 bits (208), Expect = 1.548e-18
Identity = 44/125 (35.20%), Postives = 65/125 (52.00%), Query Frame = 1

Query:  232 KSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVS-FEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            K K RR I K   PIK       +     +F +G+ Y IGD+VS  ++ +G  YYAQIR        +K   +TWL+P      + F+P+ +I+G EED  R + +  FV   PS+YF    +P+
Sbjct:  110 KGKGRRHIFKLKNPIKAPESVSTIVTAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFIQDQYCEKSAALTWLIPTLASPRDQFDPASYIIGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPF 234

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BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|A2VDY6|GATA1_BOVIN (GATA zinc finger domain-containing protein 1 OS=Bos taurus OX=9913 GN=GATAD1 PE=2 SV=1)

HSP 1 Score: 83.9593 bits (206), Expect = 3.265e-18
Identity = 44/125 (35.20%), Postives = 65/125 (52.00%), Query Frame = 1

Query:  232 KSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVS-FEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            K K RR I K   PIK       +     +F +G+ Y IGD+VS  ++ +G  YYAQIR        +K   +TWL+P      + F+P+ +I+G EED  R + +  FV   PS+YF    +P+
Sbjct:  116 KGKGRRHIFKLKNPIKAPESVSTIITAESIFYKGVYYQIGDVVSVIDEQDGKPYYAQIRGFVQDQYCEKSAALTWLIPTLASPRDQFDPASYIVGPEEDLPRKMEYLEFVCHAPSEYFKSRSSPF 240

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BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q7ZXY4|GATD1_XENLA (GATA zinc finger domain-containing protein 1 OS=Xenopus laevis OX=8355 GN=gatad1 PE=2 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 5.525e-14
Identity = 45/149 (30.20%), Postives = 71/149 (47.65%), Query Frame = 1

Query:  181 TISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPE-RRKMELESK------LFCEGIMYNIGDIVSFEDM-NGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            + ST  ++N  + +   +   RR+   RN   K  P   +K+  + K          G+ Y IGD+VS  D  +G  YYAQ+R        +K   +TWL+P      + F+PS +I+G +ED  R +    FV   PS+YF    +P+
Sbjct:   66 STSTSQQSNGGNTKQSKQEIHRRSARLRNTKYKATPAAEKKVSTKGKGRRHIFKLKNGLYYQIGDVVSVVDEEDGKTYYAQVRGFIQDQYCEKSAALTWLIPTLSSPKDGFDPSTYIIGPDEDLPRKMECLEFVCHAPSEYFKSRSSPF 214

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BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
Match: A0A5K4F7U8 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 135.191 bits (339), Expect = 1.229e-35
Identity = 73/165 (44.24%), Postives = 99/165 (60.00%), Query Frame = 1

Query:  151 STPRKSLRNRTISTKVRT--NNISGRGHL-KSKSRRAILKR------NPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENF 618
            S  RKS+R+R +S + R    N +G+G   KS+SRR ILKR      NPP         + L S ++ E I Y++GDIVS  D++G ++YAQIR L +    D  C +TWL+P   C  E F PS +I+G EED LR L  C  V RCPSDYF P+ +PY +++F
Sbjct:   67 SQTRKSMRSRVLSNRGRGLYGNYNGKGTAQKSRSRRHILKRETQKLGNPPAL-------ISLRSCVYHENIWYHVGDIVSLLDVDGEVFYAQIRGLATDLVGDSCCFLTWLIPASGCRDEEFRPSDYIIGMEEDVLRDLRCCKLVCRCPSDYFQPIASPYTIQSF 224

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BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
Match: Q5D8L0 (GATA zinc finger domain-containing protein OS=Schistosoma japonicum OX=6182 GN=EWB00_001614 PE=2 SV=1)

HSP 1 Score: 132.109 bits (331), Expect = 1.876e-34
Identity = 69/165 (41.82%), Postives = 100/165 (60.61%), Query Frame = 1

Query:  151 STPRKSLRNRTISTKVRT--NNISGRGH-LKSKSRRAILKR------NPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENF 618
            S  RKS+R+R ++++ R   N+ +G+G  LKS+SRR + K+      NPP         + L + +F E + Y++GDIVS  D++G I+YAQIR L +    D  C +TWL+P   C  E F PS +I+G EED LR L  C  V RCP+DYF P+ +PY ++ F
Sbjct:   66 SQTRKSMRSRVLASRSRGAYNSYNGKGTILKSRSRRHVFKKEAHKLGNPPAP-------IRLRTCVFHEDVWYHVGDIVSLLDVDGEIFYAQIRGLATDFAGDNCCFLTWLIPVSGCRDEEFRPSDYIIGMEEDVLRDLNCCKLVCRCPADYFQPIASPYTIQTF 223

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BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
Match: A0A504Z2G9 (GATA zinc finger domain-containing protein 1 OS=Fasciola gigantica OX=46835 GN=FGIG_00122 PE=4 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 9.413e-34
Identity = 62/155 (40.00%), Postives = 97/155 (62.58%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGH--LKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENF 618
            RKSLR R  STK +++  +G     LKS+SR+ ILK++P +K  P    + +   +    + +N+GDIVS  D++ G+YYAQ+R L   +  +  C +TWLVP  +  +  F P  +++G EED LR L  C+ V RCPSDY+ P+ +PY++++F
Sbjct:   54 RKSLRARVASTKTKSHLANGNKSQTLKSRSRKHILKKDP-VKLSPAPPLISMVQSVRLADVRFNVGDIVSVVDIDDGVYYAQLRALAVDAVGNSCCALTWLVPTSDTTSGTFEPENYMIGMEEDILRDLNCCSLVCRCPSDYYRPVASPYDIQSF 207

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BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
Match: A0A0R3SFG6 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS3583 PE=4 SV=1)

HSP 1 Score: 128.642 bits (322), Expect = 1.597e-33
Identity = 73/169 (43.20%), Postives = 99/169 (58.58%), Query Frame = 1

Query:  133 DLKMDYSTP-RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENFPLLNSV 636
            D   D++ P +K+LR R I+   R    +G  + KSKSRR +LK + P+K  P +  + LE++ F  GI Y IGDIVS  D+ GG YYAQIR     S+ D   V+TWLVP  E     F  SK+++G EED  R +    F + CPSDYF P+D+PY V ++    SV
Sbjct:   28 DADFDFTGPTKKTLRTRGIN---RHKFFNGSTNSKSKSRRQLLK-SIPLKISPPKPCIRLETRYFHRGIWYQIGDIVSLIDIEGGEYYAQIRTFIIDSHEDAHVVLTWLVPTVEATRGKFEASKYVIGMEEDVPRRIECVAFYAHCPSDYFRPVDSPYTVGSWAPPESV 192

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BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
Match: A0A0R3T299 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS1048 PE=4 SV=1)

HSP 1 Score: 127.487 bits (319), Expect = 4.492e-33
Identity = 69/163 (42.33%), Postives = 95/163 (58.28%), Query Frame = 1

Query:  133 DLKMDYSTP-RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENF 618
            D   D++ P +K+LR R  +   R  + +G  + K KSRR + K NP IK  P +  + LE++ F  GI Y IGDIVS  D +G  YYAQIR     S+ D   V+TWLVP  E   + F  S +++G EED  R +    F +RCPSDYF P+D+PY V ++
Sbjct:   28 DADFDFTGPAKKTLRTRGTN---RQKSFNGSANSKLKSRRQLFKSNP-IKISPAKPCIRLETRYFHRGIWYQIGDIVSLTDTDGDEYYAQIRTFIIDSHEDAHVVLTWLVPTVEAKGKKFEASNYVIGMEEDIPRRIECVAFYARCPSDYFRPVDSPYTVGSW 186

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Cavefish
Match: gatad1 (GATA zinc finger domain containing 1 [Source:NCBI gene;Acc:103047367])

HSP 1 Score: 84.3445 bits (207), Expect = 1.950e-19
Identity = 52/150 (34.67%), Postives = 76/150 (50.67%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESK-LFCEGIMYNIGDIVSFEDM-NGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            R+S R R  STK +      +   K K RR I K   PIK  PE     + S+ +F +G+ Y IGD++   D  +G  Y+AQIR        +K   +TWL+P +    + F+P  +I+G EED  R + +  FV   PS+YF     P+
Sbjct:   67 RRSARLR--STKYKAPASEKKVSTKGKGRRHIFKLKNPIK-APESVSTIITSESIFYKGVYYQIGDVIKVTDEEDGKPYFAQIRGFVQDQYCEKSAALTWLIPTQSSPRDQFDPGSYIVGPEEDLPRKMEYLEFVCHAPSEYFKSRSCPF 213

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Cavefish
Match: gatad1 (GATA zinc finger domain containing 1 [Source:NCBI gene;Acc:103047367])

HSP 1 Score: 75.0998 bits (183), Expect = 3.949e-16
Identity = 42/148 (28.38%), Postives = 70/148 (47.30%), Query Frame = 1

Query:  181 TISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESK------LFCEGIMYNIGDIVSFEDM-NGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            ++S+  + NN  G+   +   RR+   R+   K     +K+  + K          G+ Y IGD++   D  +G  Y+AQIR        +K   +TWL+P +    + F+P  +I+G EED  R + +  FV   PS+YF     P+
Sbjct:   46 SVSSTTQQNNGGGKQSKQEIHRRSARLRSTKYKAPASEKKVSTKGKGRRHIFKLKNGVYYQIGDVIKVTDEEDGKPYFAQIRGFVQDQYCEKSAALTWLIPTQSSPRDQFDPGSYIVGPEEDLPRKMEYLEFVCHAPSEYFKSRSCPF 193

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BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO42226 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S253])

HSP 1 Score: 78.9518 bits (193), Expect = 3.061e-18
Identity = 47/148 (31.76%), Postives = 79/148 (53.38%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGHLKS------KSRRAILK-RNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYF 582
            + S  +R +  +++ ++  G  + KS      K+RR + K +  P K       +   +K++ + I+Y +GD++S ED++GG+YYAQIR       + K  V+TWLVP        F+P+ F+ G EED  R +    FV R P++ F
Sbjct:   47 QSSKESRKLVARIKASSRKGHHNGKSGDKTREKNRRTLAKLKRKPYKSPTGVATVVASNKVYYKNILYQVGDVISIEDIDGGLYYAQIRGFLQDEYAVKSAVITWLVPTVP-HPPHFDPAIFLPGPEEDTPRPMECMEFVCRAPTELF 193

[Close]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Medaka
Match: gatad1 (GATA zinc finger domain containing 1 [Source:NCBI gene;Acc:101165405])

HSP 1 Score: 76.2554 bits (186), Expect = 1.401e-16
Identity = 48/149 (32.21%), Postives = 71/149 (47.65%), Query Frame = 1

Query:  160 RKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMN-GGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPY 603
            R+S R R  STK +      +   K K RR I K   PIK       +     +F +G+ Y  GD++   D + G  YYAQIR        +K   +TWL+P +    + F+P  +I+  EED  R + +  FV   PS+YF    +P+
Sbjct:   65 RRSARLR--STKYKAPASEKKVSTKGKGRRHIFKLKNPIKAPESVATIVTSESVFYKGVYYQTGDVIKVIDEDDGKPYYAQIRGFVQDQYCEKSAALTWLIPTQASPKDRFDPGTYIVP-EEDLPRKMEYLEFVCHAPSEYFKSQSSPF 210

[Close]

BLAST of GATA zinc finger domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000039948.1 (SMESG000039948.1)

HSP 1 Score: 412.92 bits (1060), Expect = 9.363e-149
Identity = 212/212 (100.00%), Postives = 212/212 (100.00%), Query Frame = 1

Query:   25 MEENQLGKDDILKSENADEVDXXXXXXXXXXXXEDGDLKMDYSTPRKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENFPLLNSVNRSFYLDQ 660
            MEENQLGKDDILKSENADEVDSNSSSKTKRKNNEDGDLKMDYSTPRKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENFPLLNSVNRSFYLDQ
Sbjct:    1 MEENQLGKDDILKSENADEVDSNSSSKTKRKNNEDGDLKMDYSTPRKSLRNRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLFCEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEECDTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENFPLLNSVNRSFYLDQ 212

The following BLAST results are available for this feature:

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Human
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Celegans
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Fly
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Zebrafish
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Xenopus
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Mouse
BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Cavefish
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Sea Lamprey
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Yeast
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Nematostella
BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Medaka
BLAST of GATA zinc finger domain-containing protein 1 vs. Planmine SMEST

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
GATAD1	3.015e-19	35.20	GATA zinc finger domain containing 1 [Source:HGNC ...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CG13367	3.520e-15	32.80	gene:FBgn0025634 transcript:FBtr0070121	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
gatad1	3.636e-20	36.67	GATA zinc finger domain containing 1 [Source:NCBI ...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
gatad1	3.205e-19	34.23	uncharacterized LOC100127267 [Source:Xenbase;Acc:X...	[more]
gatad1	8.607e-15	30.87	uncharacterized LOC100127267 [Source:Xenbase;Acc:X...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Gatad1	2.213e-19	35.20	GATA zinc finger domain containing 1 [Source:MGI S...	[more]
Gatad1	2.117e-14	35.14	GATA zinc finger domain containing 1 [Source:MGI S...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q1L8G7\|GATD1_DANRE	2.745e-19	36.67	GATA zinc finger domain-containing protein 1 OS=Da...	[more]
sp\|Q8WUU5\|GATD1_HUMAN	1.448e-18	35.20	GATA zinc finger domain-containing protein 1 OS=Ho...	[more]
sp\|Q920S3\|GATD1_MOUSE	1.548e-18	35.20	GATA zinc finger domain-containing protein 1 OS=Mu...	[more]
sp\|A2VDY6\|GATA1_BOVIN	3.265e-18	35.20	GATA zinc finger domain-containing protein 1 OS=Bo...	[more]
sp\|Q7ZXY4\|GATD1_XENLA	5.525e-14	30.20	GATA zinc finger domain-containing protein 1 OS=Xe...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A5K4F7U8	1.229e-35	44.24	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
Q5D8L0	1.876e-34	41.82	GATA zinc finger domain-containing protein OS=Schi...	[more]
A0A504Z2G9	9.413e-34	40.00	GATA zinc finger domain-containing protein 1 OS=Fa...	[more]
A0A0R3SFG6	1.597e-33	43.20	Uncharacterized protein OS=Hymenolepis diminuta OX...	[more]
A0A0R3T299	4.492e-33	42.33	Uncharacterized protein OS=Rodentolepis nana OX=10...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
gatad1	1.950e-19	34.67	GATA zinc finger domain containing 1 [Source:NCBI ...	[more]
gatad1	3.949e-16	28.38	GATA zinc finger domain containing 1 [Source:NCBI ...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO42226	3.061e-18	31.76	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
gatad1	1.401e-16	32.21	GATA zinc finger domain containing 1 [Source:NCBI ...	[more]

BLAST of GATA zinc finger domain-containing protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000039948.1	9.363e-149	100.00	SMESG000039948.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027077 ID=SMED30027077|Name=GATA zinc finger domain-containing protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=673bp
TTAAAGTTAAATTAAATTTATAAAATGGAAGAAAATCAGTTAGGTAAAGA
TGATATTTTAAAATCTGAAAATGCTGATGAAGTGGATTCTAATTCATCTT
CAAAGACAAAAAGAAAAAACAACGAAGATGGAGACCTAAAAATGGATTAT
TCTACACCAAGAAAGTCACTACGAAACCGAACTATTTCAACAAAAGTCAG
AACAAATAACATTTCTGGTCGTGGTCATTTAAAATCAAAATCGAGAAGAG
CTATCTTAAAAAGAAATCCTCCAATTAAATATGTCCCCGAAAGAAGGAAA
ATGGAATTAGAAAGTAAACTATTTTGTGAGGGCATTATGTATAATATTGG
AGATATTGTGTCCTTCGAAGATATGAATGGTGGTATATATTACGCACAAA
TTCGATACTTATTTTCCACAAGCAACAGTGATAAACTCTGCGTTGTAACT
TGGTTGGTTCCAAAAGAAGAATGCGATACAGAAGCATTTAATCCTTCTAA
ATTTATTTTAGGCTACGAAGAAGACGAATTAAGGCACCTTGCGTTTTGCA
ATTTTGTATCTCGATGCCCATCAGATTATTTCACCCCTCTCGATGCTCCA
TACGAGGTGGAAAATTTCCCTTTACTCAATTCAGTGAACAGATCATTTTA
TTTAGATCAATAAATGTGTACAG

protein sequence of SMED30027077-orf-1

>SMED30027077-orf-1 ID=SMED30027077-orf-1|Name=SMED30027077-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=213bp
MEENQLGKDDILKSENADEVDSNSSSKTKRKNNEDGDLKMDYSTPRKSLR
NRTISTKVRTNNISGRGHLKSKSRRAILKRNPPIKYVPERRKMELESKLF
CEGIMYNIGDIVSFEDMNGGIYYAQIRYLFSTSNSDKLCVVTWLVPKEEC
DTEAFNPSKFILGYEEDELRHLAFCNFVSRCPSDYFTPLDAPYEVENFPL
LNSVNRSFYLDQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001025	BAH_dom

Vocabulary: **molecular function**
Term	Definition
GO:0003682	chromatin binding
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Main menu

GATA zinc finger domain-containing protein 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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