noggin-like protein 1

Overview


Name	noggin-like protein 1 (ABV04324.1)
Smed ID	SMED30027052
Length (bp)	1028

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of noggin-like protein 1 (SMED30027052) t-SNE clustered cells

Violin plots show distribution of expression levels for noggin-like protein 1 (SMED30027052) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of noggin-like protein 1 (SMED30027052) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for noggin-like protein 1 (SMED30027052) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30027052

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30027052	SMESG000032255.1	SmedASXL_008908	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
nervous system	SMED30027052	SMESG000032255.1	dd_Smed_v4_14068_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30027052	SMESG000032255.1	dd_Smed_v4_14068_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30027052	SMESG000032255.1	dd_Smed_v4_14068_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30027052	SMESG000032255.1	dd_Smed_v4_14068_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30027052	SMESG000032255.1	dd_Smed_v6_14068_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
neuron	SMED30027052	SMESG000032255.1	Contig49725	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30027052	SMESG000032255.1	Contig49725	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
neuron	SMED30027052	SMESG000032255.1	Contig49725	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30027052	SMESG000032255.1	Contig49725	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
body wall musculature	SMED30027052	SMESG000032255.1	dd_Smed_v4_14068_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018
pharynx	SMED30027052	SMESG000032255.1	EF633691.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
cephalic ganglia	SMED30027052	SMESG000032255.1	EF633691.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
lateral branch	SMED30027052	SMESG000032255.1	EF633691.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
nervous system	SMED30027052	SMESG000032255.1	dd_Smed_v4_14068_0_1	dd_Smed_v4	PMID:30962434 Cote et al., 2019

Note: Hover over icons to view figure legend

Homology

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BLAST of noggin-like protein 1 vs. Ensembl Human
Match: NOG (noggin [Source:HGNC Symbol;Acc:HGNC:7866])

HSP 1 Score: 66.2402 bits (160), Expect = 5.824e-12
Identity = 48/159 (30.19%), Postives = 71/159 (44.65%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPS---IIYEQTSLEASNNKQLDVLL----------SFKNLSFTD--EKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P E  L+  +L+ +LG  +Y+  +M+ + P          +  A +  +LD LL            K L F++   +G+    S+ L   ++ W+  Q  C   Y W  L    WP ++K G C S   CS P GM CK S    L VL+W C
Sbjct:   50 PDPIFDPKEKDLNETLLRSLLG-GHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 1 vs. Ensembl Zebrafish
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 68.1662 bits (165), Expect = 5.675e-13
Identity = 44/145 (30.34%), Postives = 65/145 (44.83%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEK-GQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP H P E  L    L + LG  N++ ++MS++ P+ +      E     +L +    K L  T+   G+ +   +       +W+     C   Y WK L    WP +IK G C S   CS+P GM+CK     T   L+W C
Sbjct:   46 PDPEHDPREQDLSEKTLLKKLG-SNFDANFMSIHLPAQLNASAPPELP---RLPMPAELKKLDLTETPYGRRVKVGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFSERSCSFPEGMSCKPVKAVTKTFLRWYC 186

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BLAST of noggin-like protein 1 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 67.781 bits (164), Expect = 7.636e-13
Identity = 51/196 (26.02%), Postives = 86/196 (43.88%), Query Frame = 3

Query:   66 SVILIFTVWNILREPLIVNTYYSGSLIGTGLD----RSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIY----EQTSLEASNNKQLDVLL-SFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEK 623
            + +LIF++   + E +  + Y    +    L     +  PDP   P E  L+   L+ ILG  ++E ++MS+N P   +    E    E    +   ++    K + F  + G+    S+ L   ++ W+     C   + W+ L    WP ++K G C +   CS P GM CK +    L VL+W C+    G K
Sbjct:    9 ATVLIFSIGFRIEEGMCQHYYLLRPIPSDSLPIVELKEDPDPVLDPKERDLNETELRAILG-SHFEQNFMSINPPEDKHAGQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLK 203

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Query:   66 SVILIFTVWNILREPLIVNTYYSGSLIGTGLD----RSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIY----EQTSLEASNNKQLDVLL-SFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEK 623
            + +LIF++   + E +  + Y    +    L     +  PDP   P E  L+   L+ ILG  ++E ++MS+N P   +    E    E    +   ++    K + F  + G+    S+ L   ++ W+     C   + W+ L    WP ++K G C +   CS P GM CK +    L VL+W C+    G K
Sbjct:    9 ATVLIFSIGFRIEEGMCQHYYLLRPIPSDSLPIVELKEDPDPVLDPKERDLNETELRAILG-SHFEQNFMSINPPEDKHAGQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLK 203

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BLAST of noggin-like protein 1 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 67.3958 bits (163), Expect = 1.388e-12
Identity = 51/196 (26.02%), Postives = 86/196 (43.88%), Query Frame = 3

Query:   66 SVILIFTVWNILREPLIVNTYYSGSLIGTGLD----RSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIY----EQTSLEASNNKQLDVLL-SFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEK 623
            + +LIF++   + E +  + Y    +    L     +  PDP   P E  L+   L+ ILG  ++E ++MS+N P   +    E    E    +   ++    K + F  + G+    S+ L   ++ W+     C   + W+ L    WP ++K G C +   CS P GM CK +    L VL+W C+    G K
Sbjct:    9 ATVLIFSLGFRIEEGMCQHYYLLRPIPSDSLPIVELKEDPDPVLDPKERDLNETELRAILG-SHFEQNFMSINPPEDKHAGQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLK 203

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BLAST of noggin-like protein 1 vs. Ensembl Zebrafish
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 60.4622 bits (145), Expect = 2.878e-10
Identity = 41/155 (26.45%), Postives = 72/155 (46.45%), Query Frame = 3

Query:  162 RSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLS------FKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLS 605
            +  PDP + P E  L+   L+  LG  +++  ++S+  P   Y     E  + ++L + L+       KNL F    G+    S+ L   ++ W+   + C   Y W  L    WP +++ G C +   CS P GM CK +    + +L+W C++
Sbjct:   40 KEDPDPLYDPREKDLNETELRSALG--DFDSRFLSVGPPQDRYAGN--EDLDEQELQLNLAGMMPKDIKNLDFDAPWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTKRSCSVPEGMVCKPAKSTHITLLRWRCVA 190

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BLAST of noggin-like protein 1 vs. Ensembl Xenopus
Match: nog4 (noggin 4 [Source:NCBI gene;Acc:733455])

HSP 1 Score: 75.0998 bits (183), Expect = 4.460e-15
Identity = 43/142 (30.28%), Postives = 66/142 (46.48%), Query Frame = 3

Query:  240 NYEHSWMSMNTPSI------------IYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGIC-SSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKW 626
            +++  WMS+  P+             +Y+  S       Q    L F +L    E     N+S ++   IR+W+VQ+A+C+    W  L    WP W++H  C  +   CSWPPGMAC+Q+    +K+L W C     G  W
Sbjct:   84 SFDPFWMSVEQPADNDTSLLSTLSQDLYDGASRYRKKLAQEAQALDFGSLQLPRELS--ANSSLHVQNEIRQWLVQRASCQLTSTWVDLGTVFWPRWVRHTDCDGANTACSWPPGMACRQAQLTQIKLLAWHCWMKDTGLGW 223

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BLAST of noggin-like protein 1 vs. Ensembl Xenopus
Match: acad10 (acyl-CoA dehydrogenase family member 10 [Source:Xenbase;Acc:XB-GENE-967980])

HSP 1 Score: 69.707 bits (169), Expect = 2.477e-13
Identity = 47/146 (32.19%), Postives = 67/146 (45.89%), Query Frame = 3

Query:  171 PDPHK-PGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQL-DVLLSFKNLSFTDEK-GQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP + P E  LD   L++ LG  N++ ++MS+  P+ +   T    +  K L  V L  K L  ++   G  I   +       +W+     C   Y WK L    WP +IK G C S + CS+P GM CK     T   L+W C
Sbjct:   48 PDPEQDPKEQDLDERTLRKKLG-SNFDPNFMSVVLPNSVNMSTQDSLTKMKTLGSVPLELKKLDLSETPYGGRIRMGKKARRKFLQWLWAYTYCPVMYTWKDLGVRFWPRFIKEGHCFSEKSCSFPEGMYCKPIKSVTKTFLRWYC 192

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BLAST of noggin-like protein 1 vs. Ensembl Xenopus
Match: nog (noggin [Source:NCBI gene;Acc:493191])

HSP 1 Score: 63.1586 bits (152), Expect = 4.352e-11
Identity = 42/150 (28.00%), Postives = 68/150 (45.33%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTP----SIIYEQTSLEASNNKQLDVLLS-FKNLSFTDE-KGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP + P E  L+  +L R L + +++ ++M++N P     +            K    + +  K L F +  +G+    S+ L   ++ W+  Q  C   Y W  L    WP ++K G C S   CS P GM CK +    L +L+W C
Sbjct:   49 PDPIYDPKEKDLNETLL-RTLMVGHFDPNFMAINLPEERLGVEDLGELDLLLRQKPSGAMPAEIKGLEFYEGLQGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKRSCSVPEGMVCKAAKSMHLTILRWRC 197

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BLAST of noggin-like protein 1 vs. Ensembl Mouse
Match: Nog (noggin [Source:MGI Symbol;Acc:MGI:104327])

HSP 1 Score: 66.2402 bits (160), Expect = 3.398e-12
Identity = 48/159 (30.19%), Postives = 71/159 (44.65%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPS---IIYEQTSLEASNNKQLDVLL----------SFKNLSFTD--EKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P E  L+  +L+ +LG  +Y+  +M+ + P          +  A +  +LD LL            K L F++   +G+    S+ L   ++ W+  Q  C   Y W  L    WP ++K G C S   CS P GM CK S    L VL+W C
Sbjct:   50 PDPIFDPKEKDLNETLLRSLLG-GHYDPGFMATSPPEDRPGGGGGPAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 1 vs. UniProt/SwissProt
Match: sp|Q9W740|NOGG2_DANRE (Noggin-2 OS=Danio rerio OX=7955 GN=nog2 PE=2 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 4.284e-12
Identity = 44/145 (30.34%), Postives = 65/145 (44.83%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEK-GQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP H P E  L    L + LG  N++ ++MS++ P+ +      E     +L +    K L  T+   G+ +   +       +W+     C   Y WK L    WP +IK G C S   CS+P GM+CK     T   L+W C
Sbjct:   46 PDPEHDPREQDLSEKTLLKKLG-SNFDANFMSIHLPAQLNASAPPELP---RLPMPAELKKLDLTETPYGRRVKVGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFSERSCSFPEGMSCKPVKAVTKTFLRWYC 186

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BLAST of noggin-like protein 1 vs. UniProt/SwissProt
Match: sp|Q9YHV3|NOGG3_DANRE (Noggin-3 OS=Danio rerio OX=7955 GN=nog3 PE=1 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 1.884e-11
Identity = 51/196 (26.02%), Postives = 85/196 (43.37%), Query Frame = 3

Query:   66 SVILIFTVWNILREPLIVNTYYSGSLIGTGLD----RSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIY----EQTSLEASNNKQLDVLL-SFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEK 623
            + +LIF++   + E +  + Y    +    L     +  PDP   P E  L+   L+ ILG  ++E ++MS+N P   +    E    E    +   ++    K + F  + G+    S+ L   ++ W+     C   + W+ L    WP ++K G C +   CS P GM CK      L VL+W C+    G K
Sbjct:    9 ATVLIFSLGFRIEEGMCQHYYLLRPIPSDSLPIVELKEDPDPVLDPKERDLNETELRAILG-SHFEQNFMSINPPEDKHAGQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKRSCSVPEGMVCKPPKSSHLTVLRWRCVQRKGGLK 203

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BLAST of noggin-like protein 1 vs. UniProt/SwissProt
Match: sp|P97466|NOGG_MOUSE (Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1)

HSP 1 Score: 66.2402 bits (160), Expect = 2.377e-11
Identity = 48/159 (30.19%), Postives = 71/159 (44.65%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPS---IIYEQTSLEASNNKQLDVLL----------SFKNLSFTD--EKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P E  L+  +L+ +LG  +Y+  +M+ + P          +  A +  +LD LL            K L F++   +G+    S+ L   ++ W+  Q  C   Y W  L    WP ++K G C S   CS P GM CK S    L VL+W C
Sbjct:   50 PDPIFDPKEKDLNETLLRSLLG-GHYDPGFMATSPPEDRPGGGGGPAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 1 vs. UniProt/SwissProt
Match: sp|Q13253|NOGG_HUMAN (Noggin OS=Homo sapiens OX=9606 GN=NOG PE=1 SV=1)

HSP 1 Score: 66.2402 bits (160), Expect = 2.797e-11
Identity = 48/159 (30.19%), Postives = 71/159 (44.65%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPS---IIYEQTSLEASNNKQLDVLL----------SFKNLSFTD--EKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P E  L+  +L+ +LG  +Y+  +M+ + P          +  A +  +LD LL            K L F++   +G+    S+ L   ++ W+  Q  C   Y W  L    WP ++K G C S   CS P GM CK S    L VL+W C
Sbjct:   50 PDPIFDPKEKDLNETLLRSLLG-GHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC 207

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BLAST of noggin-like protein 1 vs. UniProt/SwissProt
Match: sp|O93525|NOGG_CHICK (Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1)

HSP 1 Score: 63.929 bits (154), Expect = 1.565e-10
Identity = 41/151 (27.15%), Postives = 67/151 (44.37%), Query Frame = 3

Query:  171 PDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTP----SIIYEQTSLEASNNKQLDVLLS-FKNLSFTD--EKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P E  L+  +L+ ++G  +++ ++M+M+ P     +            +    +    K L F D  + G+    S+ L   ++ W+  Q  C   Y W  L    WP ++K G C S   CS P GM CK +    L +L+W C
Sbjct:   49 PDPIFDPKEKDLNETLLRSLMG-GHFDPNFMAMSLPEDRLGVDDLAELDLLLRQRPSGAMPGEIKGLEFYDGLQPGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGSRFWPRYVKVGSCYSKRSCSVPEGMVCKPAKSVHLTILRWRC 198

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BLAST of noggin-like protein 1 vs. TrEMBL
Match: A8SLH5 (Noggin-like protein 1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 473.011 bits (1216), Expect = 3.765e-166
Identity = 269/269 (100.00%), Postives = 269/269 (100.00%), Query Frame = 3

Query:   57 MVNSVILIFTVWNILREPLIVNTYYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            MVNSVILIFTVWNILREPLIVNTYYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDRKRRRLRRHQFKRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGYLCQWKPIDYTVYESCTCSC
Sbjct:    1 MVNSVILIFTVWNILREPLIVNTYYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDRKRRRLRRHQFKRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 269

[Close]

BLAST of noggin-like protein 1 vs. TrEMBL
Match: Q8MY69 (Noggin like protein OS=Dugesia japonica OX=6161 GN=Djnlg PE=2 SV=1)

HSP 1 Score: 340.887 bits (873), Expect = 7.548e-114
Identity = 183/273 (67.03%), Postives = 225/273 (82.42%), Query Frame = 3

Query:   57 MVNSVILIFTVWNILREPLIVNTYYSG--SLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC*G 869
            MVNS+I +  + NI +E   VN YYSG  ++  T  DRSTPDPH PGENAL+V +LQ+ILG +NY+ SWMS+NTPS IYE  +++  NNK LDVLLSFKNL+ TDE GQLINTS+NL++AIRRWMVQQA CK DY+WKRLD+THWPS+IKHG+C+S E CSWPPGM C+ +D+K LK+LKWTC+SDPLG++WN FRE +  D+++RRLRRH+ KRHLSQ  K    KV +PK++KRLVKRYLY+TSKY SGYLCQWKPIDYTV++SCTCSC G
Sbjct:    1 MVNSLIFVLAILNIFQESFTVNAYYSGRINMHSTNTDRSTPDPHVPGENALNVKLLQKILGKRNYDFSWMSINTPSKIYEPANIDIPNNKLLDVLLSFKNLTLTDENGQLINTSKNLESAIRRWMVQQAACKIDYLWKRLDDTHWPSFIKHGVCNSRESCSWPPGMNCRPNDQKLLKILKWTCISDPLGKRWNEFRESIFADKRKRRLRRHKIKRHLSQ--KRKTNKVIRPKRMKRLVKRYLYRTSKYVSGYLCQWKPIDYTVHQSCTCSCQG 271

[Close]

BLAST of noggin-like protein 1 vs. TrEMBL
Match: T1D134 (Nlg1 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 218.009 bits (554), Expect = 1.138e-65
Identity = 108/250 (43.20%), Postives = 157/250 (62.80%), Query Frame = 3

Query:  123 TYYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRE---LMHEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
             Y+  + +     +++ DP  P +N+ +   L+ I+G KNY+ +WMS+N P  I+E  +     ++ L +L +FKN +  DE G  +   +N+  AIRRW+V+QA+C+ +Y+WK+LD  HWPSWIKHGICSS E CSWPPGM+C+    K  K+LKW C SDP   KWN FRE    + + R   R RRH  K+    K++ G+    + K+ ++   RY YKTSKY  G+ CQW+P+DY+V E+C CSC
Sbjct:   19 NYFQNNPMTPSQKKNSMDPFHPDDNSYNTKHLKAIMGGKNYDVTWMSINRPPKIFESANFSKPPSRNLLMLSNFKNYTLVDEVGNEMKIPKNISTAIRRWIVEQASCRVEYVWKKLDALHWPSWIKHGICSSKESCSWPPGMSCRNESHKKFKILKWICNSDPFAHKWNEFREKFLQLRKSRLLNRKRRHNLKKSNLVKQRRGLNFPNRSKRDEKKRLRYAYKTSKYVQGFFCQWEPVDYSVVETCMCSC 268

[Close]

BLAST of noggin-like protein 1 vs. TrEMBL
Match: C1JAC3 (Noggin-like protein 3 OS=Schmidtea mediterranea OX=79327 GN=nlg3 PE=2 SV=1)

HSP 1 Score: 128.642 bits (322), Expect = 3.491e-31
Identity = 65/231 (28.14%), Postives = 132/231 (57.14%), Query Frame = 3

Query:  180 HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELM---HEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            H P        ILQ+I+       +W+S+  P  +Y+ ++   + +K++  L+  KN++  D+ G  IN S+ +  +I++W+++++ C+ +Y W+ L+ET+WP W+K G+C + + CSWPPGM+C  +  + L +L+W C  D   EK+   + L+    + R++R+   +  K    ++     +K+++ +     ++  L+K S Y  G+ C+W+ + Y V ++C+C+C
Sbjct:   43 HFPNITHNTRRILQQIIHNGILVDNWISITKPHQLYQSSNEPENVSKRMRFLVKMKNITLIDKNGFKINISKTILTSIQQWLIEESKCQVEYHWQELNETYWPRWVKKGLCVNIKSCSWPPGMSCSPNSYRKLSLLQWICAEDKSKEKYKDDKLLIKIARKIRRKRQNISNNSKFKSKKRWLRLPRKLEESQSNAIKIRLRLFKLSLYTEGFYCKWREVHYRVIQTCSCNC 273

[Close]

BLAST of noggin-like protein 1 vs. TrEMBL
Match: C1JAC2 (Noggin-like protein 2 OS=Schmidtea mediterranea OX=79327 GN=nlg2 PE=2 SV=1)

HSP 1 Score: 125.946 bits (315), Expect = 4.118e-30
Identity = 80/221 (36.20%), Postives = 116/221 (52.49%), Query Frame = 3

Query:  216 LQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSF----KNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHE-DXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            L++IL  +     W+S   P  IY    +  +  KQ+DV + F    KN +F D KG  +  S N+  + RRW+ Q+++C  DYIW  LD + WP W+K GIC S   CSWPPGM CK   KK L +L+W C  DP   K+ A    M    R R + +    KR  +  ++ GV+KV   K  +   K+ + K  ++   + C+WK + Y V E C+C C
Sbjct:   70 LRQILDQEQLFDDWISSRIPKQIY----IPFNGTKQVDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIEFCSCYC 286

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Cavefish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 53.1434 bits (126), Expect = 5.667e-8
Identity = 38/151 (25.17%), Postives = 65/151 (43.05%), Query Frame = 3

Query:  171 PDPH-KPGENALDVHILQRILGLKNYEHSWMSMNTPSII-YEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLG 617
            PDP   P +  L+   L+  LG  +++  +M+++ P     + + L        D+    + L F  E       S+ +   ++ W+     C   Y W+ L    WP ++K G C+S   CS P GM C  +    L +L+W C+    G
Sbjct:   35 PDPALDPKDRDLNETELRARLG-AHFDAHFMAVSAPGAADTDASRLRPPGPMPRDI----RTLDF--ELPGWKKPSKKMRRRLQLWLWSYTFCPVVYAWQDLGSRFWPRYVKVGSCASKRSCSVPEGMVCSPAKSAHLTLLRWYCIPRKAG 178

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009391.1 (pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-1 gene:ENSPMAG00000008500.1 transcript:ENSPMAT00000009391.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 67.0106 bits (162), Expect = 1.919e-13
Identity = 39/151 (25.83%), Postives = 66/151 (43.71%), Query Frame = 3

Query:  186 PGENALDVHILQRILGLKNYEHSWMSMNTPS---------IIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGIC--SSTEPCSWPPGMACKQSDKKTLKVLKWTCLS 605
            P +  L    L  ILG  +++  WMS+  PS          +  ++S   +  ++L       N +   + G  +  ++   A + RW++Q+A C     W  L    WP W++   C  S    CSWP GM+C  +    +K+L W C +
Sbjct:   24 PKQRDLKSARLHNILG-SSFDPFWMSVKRPSSSSTTGDIGALATRSSAVTAAGRKLHAAARALNFTVLTDSGAAVAATEATAAFMTRWLLQKAECGVASSWHDLGSVFWPRWVRRSHCEESGGGGCSWPAGMSCAPAQSTHIKILAWHCYA 173

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Sea Lamprey
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 65.0846 bits (157), Expect = 1.088e-12
Identity = 44/149 (29.53%), Postives = 68/149 (45.64%), Query Frame = 3

Query:  171 PDPH-KPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKN-LSFTD----EKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P E  LD  +L+R LG  +++  +M+++ P    + +  +    + L    S  N +   D      GQ I   +     I +W+     C   Y WK L E  WP ++K G C +   CS+P GMACK     +  +L+W C
Sbjct:   50 PDPELDPKEQDLDEKLLRRKLG-ASFDPEFMAVSLPK--GDASGQQTRGGRLLKPSGSMPNEIKRLDLGVLPHGQKIKIGKRARRKILQWLWSYTFCPVLYTWKDLGERFWPRFVKEGSCYNGRSCSFPEGMACKPFKSASKTLLRWHC 195

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011420.1 (pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gene:ENSPMAG00000010393.1 transcript:ENSPMAT00000011420.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.5362 bits (140), Expect = 2.279e-10
Identity = 42/166 (25.30%), Postives = 67/166 (40.36%), Query Frame = 3

Query:  171 PDPH-KPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVL----------------LSFKNLSFTDEKGQLINTSQNLDAAIRR------WMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P    LD  +L+R+LG  +++ ++MS+  P  +       +   +Q                    + F   ++ D +G   + +  L    RR      W   Q  C   Y WK L    WP +++ G C S   CS P GM+CK     +  +L+W C
Sbjct:   50 PDPELDPKTKDLDERVLRRLLG-SHFDPTFMSVAAPGEVRGLAKNASEPGEQHGRGAAAARRERAMPSEIRDMDFARAAWPDPRG---SRAGALGRKARRKMQLFLWAYTQ--CPVAYAWKDLGGRFWPRYVREGSCQSGRSCSIPAGMSCKAQRSTSKAILRWYC 209

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Sea Lamprey
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 58.151 bits (139), Expect = 2.978e-10
Identity = 44/161 (27.33%), Postives = 61/161 (37.89%), Query Frame = 3

Query:  171 PDPH-KPGENALDVHILQRILGLKNYEHSWMSMNTPS----------------IIYEQTSLEASNNKQLDVLLSFKNLSFTDE-KGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            PDP   P    LD   L + LG  N++H++MS+ TP                      T+ +        +    K L  T+   GQ +   +       +W+     C   Y WK L+   WP +IK G C S   CS P GM CK         L+W C
Sbjct:   47 PDPELDPKAKDLDERALLKKLG-SNFDHNFMSIATPESERQPGGESTTTTTTTTTAAVTAADRKPKPTGPIPSDIKRLDLTETLYGQKLKLGKRARRKFLQWLWAHTACPVVYSWKELNVRFWPRYIKEGSCYSARSCSVPEGMVCKPVKFSNKTFLRWHC 206

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Nematostella
Match: EDO36981 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH37])

HSP 1 Score: 48.1358 bits (113), Expect = 2.522e-7
Identity = 20/73 (27.40%), Postives = 38/73 (52.05%), Query Frame = 3

Query:  390 SQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSD 608
            S+ ++  +  W++Q+  C   Y W+ +    WP ++K   C S + CS  P   C+ S+ +   +L+W C+ D
Sbjct:    2 SREMERFMMGWLLQRENCPVVYSWRDMGPHFWPRFVKRATCKSKQ-CSIDPSTQCEPSNSRYFNILRWHCMDD 73

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Nematostella
Match: EDO36952 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH36])

HSP 1 Score: 46.595 bits (109), Expect = 9.643e-7
Identity = 23/76 (30.26%), Postives = 37/76 (48.68%), Query Frame = 3

Query:  372 GQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            G+  N        ++ W+ + ++C     WK   +  WP +   G CS    CS+P GM CK+S  K + +L+W C
Sbjct:   15 GEGRNLGPKASRKLQLWLWELSSCPVYQKWKDQGQLIWPRYRNIGRCSRKSTCSYPGGMKCKRSKTKRVALLRWFC 90

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Medaka
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 67.781 bits (164), Expect = 7.241e-13
Identity = 46/151 (30.46%), Postives = 71/151 (47.02%), Query Frame = 3

Query:  162 RSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNK---QLDVLLSFKNLSFTDEK-GQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTC 599
            R  PDP + P E  L    L++ LG  N++ ++MS+++P     Q +L AS+ +   Q  +    K L  T+   G+ +   +       +W+     C   Y WK L    WP +IK G C S   CS+P GM+CK +       L+W C
Sbjct:   44 REDPDPEYDPREQDLAERTLRKKLG-SNFDPNFMSISSPL----QVNLSASDYQVKLQGPMPNEIKKLDLTETPYGKRVKVGKKARRKFLQWLWTYTHCPVVYTWKDLGVRFWPRYIKEGKCFSERSCSFPEGMSCKPAKSINKIFLRWYC 189

[Close]

BLAST of noggin-like protein 1 vs. Ensembl Medaka
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 58.5362 bits (140), Expect = 1.271e-9
Identity = 47/181 (25.97%), Postives = 80/181 (44.20%), Query Frame = 3

Query:  111 LIVNTYYSGSLIGTGLDRSTPDP-HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLL---------SFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEK 623
            LI+    S SL    L +  PDP + P E   +   L+ ILG  +++  ++S++ P  +       A+N++  D  L           + + F  + G+    S+ L   +++W+   + C   Y W  L    WP +++ G C S   CS P GM CK +    L  L+W C+     E+
Sbjct:   35 LILRPIPSDSLPLVEL-KEDPDPVYDPKERDFNETELKSILG--DFDSRFLSVSPPVEVKH-----AANDELDDFALQRAGGIMPKEIRAVDFDLQSGKKHKPSKKLKRRLQQWLWAYSFCPVLYSWTDLGNRFWPRFVRVGSCLSKRSCSVPEGMVCKPASSTHLTTLRWRCVQRKAAER 207

[Close]

BLAST of noggin-like protein 1 vs. Planmine SMEST
Match: SMESG000032255.1 (SMESG000032255.1)

HSP 1 Score: 468.389 bits (1204), Expect = 7.263e-168
Identity = 267/269 (99.26%), Postives = 267/269 (99.26%), Query Frame = 3

Query:   57 MVNSVILIFTVWNILREPLIVNTYYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            MVNSVILIFTVWNIL EPLIVN YYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDRKRRRLRRHQFKRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGYLCQWKPIDYTVYESCTCSC
Sbjct:    1 MVNSVILIFTVWNILLEPLIVNAYYSGSLIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHEDRKRRRLRRHQFKRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 269

[Close]

BLAST of noggin-like protein 1 vs. Planmine SMEST
Match: SMESG000007613.1 (SMESG000007613.1)

HSP 1 Score: 127.487 bits (319), Expect = 2.039e-34
Identity = 65/231 (28.14%), Postives = 131/231 (56.71%), Query Frame = 3

Query:  180 HKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELM---HEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            H P        ILQ+I+       +W+S+  P  +Y+ ++   + +K++  L+  KN++  D+ G  IN S+ +  +I++W+++++ C+ +Y W+ L+ET+WP W+K G+C + + CSWPPGM C  +  + L +L+W C  D   EK+   + L+    + R++R+   +  K    ++     +K+++ +     ++  L+K S Y  G+ C+W+ + Y V ++C+C+C
Sbjct:   43 HFPNITHNTRRILQQIIHNGILVDNWISITKPHQLYQSSNEPENVSKRMRFLVKMKNITLIDKNGFKINISKTILTSIQQWLIEESKCQVEYHWQELNETYWPRWVKKGLCVNIKSCSWPPGMNCSPNSYRKLSLLQWICAEDKRKEKYKDDKLLIKIARKIRRKRQNIYNNSKFKSKKRWLRLPRKLEESQSNAIKIRLRLFKLSLYTEGFYCKWREVHYRVIQTCSCNC 273

[Close]

BLAST of noggin-like protein 1 vs. Planmine SMEST
Match: SMESG000034689.1 (SMESG000034689.1)

HSP 1 Score: 125.946 bits (315), Expect = 1.145e-33
Identity = 80/221 (36.20%), Postives = 116/221 (52.49%), Query Frame = 3

Query:  216 LQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSF----KNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHE-DXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            L++IL  +     W+S   P  IY    +  +  KQ+DV + F    KN +F D KG  +  S N+  + RRW+ Q+++C  DYIW  LD + WP W+K GIC S   CSWPPGM CK   KK L +L+W C  DP   K+ A    M    R R + +    KR  +  ++ GV+KV   K  +   K+ + K  ++   + C+WK + Y V E C+C C
Sbjct:   70 LRQILDQEQLFDDWISSRIPKQIY----IPFNGTKQVDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIEFCSCYC 286

[Close]

BLAST of noggin-like protein 1 vs. Planmine SMEST
Match: SMESG000034679.1 (SMESG000034679.1)

HSP 1 Score: 125.946 bits (315), Expect = 1.145e-33
Identity = 80/221 (36.20%), Postives = 116/221 (52.49%), Query Frame = 3

Query:  216 LQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSF----KNLSFTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHE-DXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            L++IL  +     W+S   P  IY    +  +  KQ+DV + F    KN +F D KG  +  S N+  + RRW+ Q+++C  DYIW  LD + WP W+K GIC S   CSWPPGM CK   KK L +L+W C  DP   K+ A    M    R R + +    KR  +  ++ GV+KV   K  +   K+ + K  ++   + C+WK + Y V E C+C C
Sbjct:   70 LRQILDQEQLFDDWISSRIPKQIY----IPFNGTKQVDVRIQFLVKMKNYTFKDRKGNKLYLSPNVVDSFRRWLEQESSCPMDYIWTELDPSFWPRWVKKGICVSVVSCSWPPGMNCKSKHKKKLTLLQWNCEIDPDKSKYKADTMQMRSIKRIRVKRQNKLHKRRNTSSKRRGVRKVMTSKSKELKNKKRILKLREHIDDFYCKWKKVTYQVIEFCSCYC 286

[Close]

BLAST of noggin-like protein 1 vs. Planmine SMEST
Match: SMESG000016086.1 (SMESG000016086.1)

HSP 1 Score: 125.176 bits (313), Expect = 3.785e-33
Identity = 70/247 (28.34%), Postives = 129/247 (52.23%), Query Frame = 3

Query:  141 LIGTGLDRSTPDPHKPGENALDVHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLSFT--DEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHGICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLG---EKWNAFR-ELMHEDXXXXXXXXXXXXXXXSQXXXXXXXXXXXXXXXXXXXXXYLYKTSKYASGYLCQWKPIDYTVYESCTCSC 863
            LIG  +  +     KP     +   L+++    + +  W+S+N P ++     +E  N +Q +++ +  NL+FT  D  G ++   +N+    R+W+++ ++C+ +++W+ L E  WPSWI+ G+C+S++ CSWP GMACK S  +TL +L+W CL D  G   +K   F+ +L  +  K++ L   + +R      +      +   + K      L   S+ + GY CQW  + Y + + C+C C
Sbjct:   69 LIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQ-ELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTSSKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQMLYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLL--SRASDGYFCQWSMLKYYINDKCSCQC 312

The following BLAST results are available for this feature:

BLAST of noggin-like protein 1 vs. Ensembl Human
BLAST of noggin-like protein 1 vs. Ensembl Celegans
BLAST of noggin-like protein 1 vs. Ensembl Fly
BLAST of noggin-like protein 1 vs. Ensembl Zebrafish
BLAST of noggin-like protein 1 vs. Ensembl Xenopus
BLAST of noggin-like protein 1 vs. Ensembl Mouse
BLAST of noggin-like protein 1 vs. UniProt/SwissProt
BLAST of noggin-like protein 1 vs. TrEMBL
BLAST of noggin-like protein 1 vs. Ensembl Cavefish
BLAST of noggin-like protein 1 vs. Ensembl Sea Lamprey
BLAST of noggin-like protein 1 vs. Ensembl Yeast
BLAST of noggin-like protein 1 vs. Ensembl Nematostella
BLAST of noggin-like protein 1 vs. Ensembl Medaka
BLAST of noggin-like protein 1 vs. Planmine SMEST

BLAST of noggin-like protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
NOG	5.824e-12	30.19	noggin [Source:HGNC Symbol;Acc:HGNC:7866]	[more]

BLAST of noggin-like protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nog2	5.675e-13	30.34	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog3	7.636e-13	26.02	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	7.636e-13	26.02	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	1.388e-12	26.02	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog1	2.878e-10	26.45	noggin 1 [Source:NCBI gene;Acc:30174]	[more]

BLAST of noggin-like protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nog4	4.460e-15	30.28	noggin 4 [Source:NCBI gene;Acc:733455]	[more]
acad10	2.477e-13	32.19	acyl-CoA dehydrogenase family member 10 [Source:Xe...	[more]
nog	4.352e-11	28.00	noggin [Source:NCBI gene;Acc:493191]	[more]

BLAST of noggin-like protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Nog	3.398e-12	30.19	noggin [Source:MGI Symbol;Acc:MGI:104327]	[more]

BLAST of noggin-like protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9W740\|NOGG2_DANRE	4.284e-12	30.34	Noggin-2 OS=Danio rerio OX=7955 GN=nog2 PE=2 SV=1	[more]
sp\|Q9YHV3\|NOGG3_DANRE	1.884e-11	26.02	Noggin-3 OS=Danio rerio OX=7955 GN=nog3 PE=1 SV=1	[more]
sp\|P97466\|NOGG_MOUSE	2.377e-11	30.19	Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1	[more]
sp\|Q13253\|NOGG_HUMAN	2.797e-11	30.19	Noggin OS=Homo sapiens OX=9606 GN=NOG PE=1 SV=1	[more]
sp\|O93525\|NOGG_CHICK	1.565e-10	27.15	Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1	[more]

BLAST of noggin-like protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A8SLH5	3.765e-166	100.00	Noggin-like protein 1 OS=Schmidtea mediterranea OX...	[more]
Q8MY69	7.548e-114	67.03	Noggin like protein OS=Dugesia japonica OX=6161 GN...	[more]
T1D134	1.138e-65	43.20	Nlg1 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1	[more]
C1JAC3	3.491e-31	28.14	Noggin-like protein 3 OS=Schmidtea mediterranea OX...	[more]
C1JAC2	4.118e-30	36.20	Noggin-like protein 2 OS=Schmidtea mediterranea OX...	[more]

BLAST of noggin-like protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
nog3	5.667e-8	25.17	noggin 3 [Source:NCBI gene;Acc:30173]	[more]

BLAST of noggin-like protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000009391.1	1.919e-13	25.83	pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-...	[more]
nog3	1.088e-12	29.53	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
ENSPMAT00000011420.1	2.279e-10	25.30	pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gen...	[more]
nog2	2.978e-10	27.33	noggin 2 [Source:NCBI gene;Acc:30185]	[more]

BLAST of noggin-like protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36981	2.522e-7	27.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36952	9.643e-7	30.26	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of noggin-like protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog2	7.241e-13	30.46	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog1	1.271e-9	25.97	noggin 1 [Source:NCBI gene;Acc:30174]	[more]

BLAST of noggin-like protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000032255.1	7.263e-168	99.26	SMESG000032255.1	[more]
SMESG000007613.1	2.039e-34	28.14	SMESG000007613.1	[more]
SMESG000034689.1	1.145e-33	36.20	SMESG000034689.1	[more]
SMESG000034679.1	1.145e-33	36.20	SMESG000034679.1	[more]
SMESG000016086.1	3.785e-33	28.34	SMESG000016086.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30027052
GenBank	ABV04324.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30027052 ID=SMED30027052|Name=noggin-like protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1028bp
AAAAAGTTTCCTATTTAATAGGGAGGAAACTAAGAAATTTTGCACATAGT
TGAGTCATGGTAAATTCTGTGATCTTGATATTTACTGTTTGGAACATTTT
ACGAGAACCGTTGATAGTTAATACATACTATAGCGGAAGTTTAATCGGGA
CAGGATTGGACCGAAGTACCCCAGATCCACATAAGCCTGGGGAAAACGCT
CTAGACGTTCATATACTACAGAGAATTCTCGGTCTGAAAAACTATGAACA
TTCTTGGATGTCAATGAATACTCCATCGATCATTTACGAGCAAACGAGTC
TCGAAGCTTCAAATAATAAACAACTAGACGTTTTACTATCATTTAAAAAC
TTATCATTTACAGACGAAAAGGGTCAATTGATCAACACTTCTCAGAATCT
TGATGCAGCCATTCGTCGGTGGATGGTCCAGCAAGCGACATGCAAAACTG
ATTACATATGGAAACGACTCGATGAAACTCATTGGCCGTCATGGATTAAA
CACGGTATTTGTAGCAGTACAGAGCCATGCTCATGGCCTCCAGGAATGGC
CTGCAAACAGAGTGATAAAAAAACCTTAAAAGTCCTCAAATGGACTTGTT
TATCAGATCCTTTAGGTGAGAAATGGAACGCATTTCGAGAATTAATGCAC
GAAGATAGAAAAAGACGAAGACTAAGAAGACATCAATTTAAAAGACACTT
ATCACAGAAAAGAAAGATCGGAGTGAAGAAAGTGAAAAAACCGAAACAAT
TAAAAAGACTAGTAAAGAGATATCTATACAAAACGAGCAAATACGCCAGT
GGTTACCTATGCCAGTGGAAACCAATAGATTATACAGTTTATGAATCTTG
CACATGTAGCTGTTAAGGATGATCGTGATAATATTGTTGCTTTTTTGAGA
GATTTCACATACCTCATGAATATATTTCGATTTATTATTTATGTTTTTAG
CTTTAGACGATAATAAATTGTGAATAATCAGTTTGTATTTGTTACTTTAG
AGGTTGAGCTTTTTTTGCAATTTTTCAA

protein sequence of SMED30027052-orf-1

>SMED30027052-orf-1 ID=SMED30027052-orf-1|Name=SMED30027052-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=270bp
MVNSVILIFTVWNILREPLIVNTYYSGSLIGTGLDRSTPDPHKPGENALD
VHILQRILGLKNYEHSWMSMNTPSIIYEQTSLEASNNKQLDVLLSFKNLS
FTDEKGQLINTSQNLDAAIRRWMVQQATCKTDYIWKRLDETHWPSWIKHG
ICSSTEPCSWPPGMACKQSDKKTLKVLKWTCLSDPLGEKWNAFRELMHED
RKRRRLRRHQFKRHLSQKRKIGVKKVKKPKQLKRLVKRYLYKTSKYASGY
LCQWKPIDYTVYESCTCSC*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000025	nervous system
PLANA:0000044	cephalic ganglia
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0000240	body wall musculature
PLANA:0000418	head
PLANA:0000461	lateral branch
PLANA:0003001	lateral region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR029034	Cystine-knot_cytokine
IPR008717	Noggin

Vocabulary: **biological process**
Term	Definition
GO:0045596	negative regulation of cell differentiation
GO:0030514	negative regulation of BMP signaling pathway

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PFAM	PF05806	Noggin	coord: 38..269 e-value: 5.1E-20 score: 72.3
None	No IPR available	GENE3D	G3DSA:1.10.287.520		coord: 78..128 e-value: 1.4E-28 score: 102.3
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..23 score: 0.665
IPR029034	Cystine-knot cytokine	GENE3D	G3DSA:2.10.90.10		coord: 40..183 e-value: 1.4E-28 score: 102.3
IPR029034	Cystine-knot cytokine	SUPERFAMILY	SSF57501	Cystine-knot cytokines	coord: 38..269
IPR008717	Noggin	PIRSF	PIRSF008129	Noggin	coord: 14..269 e-value: 3.1E-59 score: 198.1
IPR008717	Noggin	PANTHER	PTHR10494	BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN	coord: 40..269

Main menu

noggin-like protein 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Owlery

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