Pseudouridine synthase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30027035 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Pseudouridine synthase vs. Ensembl Human
Match: RPUSD2 (RNA pseudouridine synthase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24180]) HSP 1 Score: 261.922 bits (668), Expect = 1.244e-80 Identity = 148/427 (34.66%), Postives = 229/427 (53.63%), Query Frame = 2 Query: 218 SDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKET-NLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHD--------------------------------------VSVHRFYE--NGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 D++ + YYF+ G RKV PY+ F++ K RW+ S+ VF +F + + ++ + L +N K +L+ +LK ND + + VHRHE PV EPI+++ E++ V+VV KPSS+PVH ++ NTV+ IL K H +++L +HR+DR+TSG+L+F K S ++ Q+RDRQ+ K Y+ V G+F E+ + CK+ + ++ KVG V V+ GK T F L YN + S+V C+PLTGRTHQIRVHLQ+LG PI NDP+YN ++WG +G+ G K+ E+L+ DL+A H + + E P+ L T + + N+ +P C EC R + + + V+FLHA RY+ ++Y + +P W Sbjct: 124 GDEHFAETSYYFEGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEAAVRAGRLQLNEKPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEE---VTCKEPILVVSYKVG---VCRVDPRGKPCETVFQRLSYNGQS--SVVRCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQAKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIALASEKAVETDVMNQETDPLCAEC--RLVRQDPLPQDLVMFLHALRYK--GPGFEYFSPMPAWA 538
BLAST of Pseudouridine synthase vs. Ensembl Human
Match: RPUSD2 (RNA pseudouridine synthase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24180]) HSP 1 Score: 214.927 bits (546), Expect = 2.277e-63 Identity = 125/351 (35.61%), Postives = 188/351 (53.56%), Query Frame = 2 Query: 443 ILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHD--------------------------------------VSVHRFYE--NGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 + K ND + + VHRHE PV EPI+++ E++ V+VV KPSS+PVH ++ NTV+ IL K H +++L +HR+DR+TSG+L+F K S ++ Q+RDRQ+ K Y+ V G+F E+ + CK+ + ++ KVG V V+ GK T F L YN + S+V C+PLTGRTHQIRVHLQ+LG PI NDP+YN ++WG +G+ G K+ E+L+ DL+A H + + E P+ L T + + N+ +P C EC R + + + V+FLHA RY+ ++Y + +P W Sbjct: 139 LRKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEE---VTCKEPILVVSYKVG---VCRVDPRGKPCETVFQRLSYNGQS--SVVRCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQAKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIALASEKAVETDVMNQETDPLCAEC--RLVRQDPLPQDLVMFLHALRYK--GPGFEYFSPMPAWA 477
BLAST of Pseudouridine synthase vs. Ensembl Human
Match: RPUSD4 (RNA pseudouridine synthase D4 [Source:HGNC Symbol;Acc:HGNC:25898]) HSP 1 Score: 72.4034 bits (176), Expect = 3.363e-13 Identity = 50/180 (27.78%), Postives = 89/180 (49.44%), Query Frame = 2 Query: 518 IIHESDTVLVVCKPSSMPVHSVSKYHF--NTVMGILHK---SHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQY-LGFPISNDPLYN 1039 I+H+ ++V+ KP +PVH V+ IL K H + L + HR+D+ T+G+++ D + + ++ R RQV+K Y A+ ++ + P G+ + VE+ ++A T++ L + + +LV +P+TG HQ+RVHL + L PI D Y+ Sbjct: 99 ILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAI-----------------TVHVPMPSAGVVDIPIVEKEAQVAVTQYQVL--SSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYS 259
BLAST of Pseudouridine synthase vs. Ensembl Human
Match: RPUSD1 (RNA pseudouridine synthase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14173]) HSP 1 Score: 65.0846 bits (157), Expect = 7.187e-11 Identity = 66/247 (26.72%), Postives = 102/247 (41.30%), Query Frame = 2 Query: 647 RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE-----EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPN 1366 R H++D TSG L + + ++R+V K YLA++ G E + + ++G + G A+ +E E K + T + L++ +S VL KPLTGRTHQ+RVH LG P+ D Y +S +D+ + +H FY L+ T+ + + E F PS D C S + + +D V L A T D D + R P Sbjct: 61 RFCHQLDFSTSGALCVALNKAAAGSAYRCFKERRVTKAYLALLRGHIQESR---VTISHAIGRNSTE-GRAHTMCIEGSQGCENPKPSLTDLVVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPVVGDLTYGEVSGREDR-------------------PFRMMLHAFY-------LRIPTDTECV---EVCTPDPFLPSLDACWSPHTLLQSLDQLVQALRA----TPDPDPEDRGPRPG 270
BLAST of Pseudouridine synthase vs. Ensembl Human
Match: RPUSD1 (RNA pseudouridine synthase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14173]) HSP 1 Score: 65.0846 bits (157), Expect = 7.187e-11 Identity = 66/247 (26.72%), Postives = 102/247 (41.30%), Query Frame = 2 Query: 647 RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE-----EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPN 1366 R H++D TSG L + + ++R+V K YLA++ G E + + ++G + G A+ +E E K + T + L++ +S VL KPLTGRTHQ+RVH LG P+ D Y +S +D+ + +H FY L+ T+ + + E F PS D C S + + +D V L A T D D + R P Sbjct: 61 RFCHQLDFSTSGALCVALNKAAAGSAYRCFKERRVTKAYLALLRGHIQESR---VTISHAIGRNSTE-GRAHTMCIEGSQGCENPKPSLTDLVVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPVVGDLTYGEVSGREDR-------------------PFRMMLHAFY-------LRIPTDTECV---EVCTPDPFLPSLDACWSPHTLLQSLDQLVQALRA----TPDPDPEDRGPRPG 270
BLAST of Pseudouridine synthase vs. Ensembl Celegans
Match: K07E8.7 (Pseudouridine synthase [Source:UniProtKB/TrEMBL;Acc:A0A0M9JJ73]) HSP 1 Score: 227.254 bits (578), Expect = 1.292e-69 Identity = 131/382 (34.29%), Postives = 209/382 (54.71%), Query Frame = 2 Query: 257 NGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKE-TNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTF----TENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-----DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 +G R + PY+ +++ K RW+ + + EVF +F S + + K + + +N ++ T++DY+++ D + H HRHE P+ D PI++I E+D + VV KP S+PVH+ +Y +TV+G L + G LRV+HR+DR TSG+LLF K+YET + ++ + K Y+ V G F +E++ C++ +G L +G ++ V GK A ++F L + Q S+V TGRTHQIRVH Q+LG PI+ D +YN WG KGK Y KS ++L ED+ H ++E NPE Q + I + + P DE + CN + ++F L+LH +Y T W ++T++P+W Sbjct: 9 DGVRHLAPYWACYRTRTKGRWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVDYVMRNGDRVEHWAHRHEHPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDRATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQV---CEQPIGPLVISMG---IQCVRPDGKDAKSRFRKLWSDGTQ--SVVQVHIETGRTHQIRVHSQFLGHPIAGDQIYNSAVWGPTKGKNADYQKSFDELCEDVRNTH--KCENWHEKPNPEFEQRMEHLAADTTPITPEAPSLTLEQRPEFDEICQK--CNVESKKVPENHFQLYLHCLKYET--KKWSFKTEMPDWA 376
BLAST of Pseudouridine synthase vs. Ensembl Celegans
Match: K07E8.7 (Pseudouridine synthase [Source:UniProtKB/TrEMBL;Acc:A0A0M9JJ73]) HSP 1 Score: 226.868 bits (577), Expect = 5.176e-69 Identity = 131/382 (34.29%), Postives = 209/382 (54.71%), Query Frame = 2 Query: 257 NGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKE-TNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTF----TENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-----DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 +G R + PY+ +++ K RW+ + + EVF +F S + + K + + +N ++ T++DY+++ D + H HRHE P+ D PI++I E+D + VV KP S+PVH+ +Y +TV+G L + G LRV+HR+DR TSG+LLF K+YET + ++ + K Y+ V G F +E++ C++ +G L +G ++ V GK A ++F L + Q S+V TGRTHQIRVH Q+LG PI+ D +YN WG KGK Y KS ++L ED+ H ++E NPE Q + I + + P DE + CN + ++F L+LH +Y T W ++T++P+W Sbjct: 51 DGVRHLAPYWACYRTRTKGRWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVDYVMRNGDRVEHWAHRHEHPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDRATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQV---CEQPIGPLVISMG---IQCVRPDGKDAKSRFRKLWSDGTQ--SVVQVHIETGRTHQIRVHSQFLGHPIAGDQIYNSAVWGPTKGKNADYQKSFDELCEDVRNTH--KCENWHEKPNPEFEQRMEHLAADTTPITPEAPSLTLEQRPEFDEICQK--CNVESKKVPENHFQLYLHCLKYET--KKWSFKTEMPDWA 418
BLAST of Pseudouridine synthase vs. Ensembl Celegans
Match: K07E8.7 (Pseudouridine synthase [Source:UniProtKB/TrEMBL;Acc:A0A0M9JJ73]) HSP 1 Score: 226.868 bits (577), Expect = 6.987e-69 Identity = 130/382 (34.03%), Postives = 210/382 (54.97%), Query Frame = 2 Query: 257 NGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKE-TNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTF----TENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-----DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 +G R + PY+ +++ K RW+ + + EVF +F S + + K + + +N ++ T++DY+++ D + H HRHE P+ D PI++I E+D + VV KP S+PVH+ +Y +TV+G L + G LRV+HR+DR TSG+LLF K+YET + ++ + K Y+ V G F +E++ C++ +G L +G ++ V GK A ++F L + Q++ V + TGRTHQIRVH Q+LG PI+ D +YN WG KGK Y KS ++L ED+ H ++E NPE Q + I + + P DE + CN + ++F L+LH +Y T W ++T++P+W Sbjct: 62 DGVRHLAPYWACYRTRTKGRWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVDYVMRNGDRVEHWAHRHEHPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDRATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQV---CEQPIGPLVISMG---IQCVRPDGKDAKSRFRKLWSDGTQSVVQVHIE--TGRTHQIRVHSQFLGHPIAGDQIYNSAVWGPTKGKNADYQKSFDELCEDVRNTH--KCENWHEKPNPEFEQRMEHLAADTTPITPEAPSLTLEQRPEFDEICQK--CNVESKKVPENHFQLYLHCLKYET--KKWSFKTEMPDWA 429
BLAST of Pseudouridine synthase vs. Ensembl Fly
Match: RluA-2 (gene:FBgn0032256 transcript:FBtr0337002) HSP 1 Score: 268.085 bits (684), Expect = 3.491e-83 Identity = 157/447 (35.12%), Postives = 240/447 (53.69%), Query Frame = 2 Query: 170 EALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCG-VYHKSKEQLIEDLMANHDVS-------------------------------------------VHRFYENGNPETLQTFTENKSIISDE--EARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 EA KT K SD+ + YYF+NG RKV+PYF TF + K RW+++ + +VF +F + P + +E L +N+++ DY +K ND++ + VHRHE+PV +PIKI++ ++VV KP+S+PVH +Y NTV+ IL K H ++ LR IHR+DR+TSG+LLFG+ E + +L QIR RQV K Y+ V G+F + +EC + + ++ K+G+ V K K F + E + S+VLCKPLTGR HQIRVHLQ+LG+PISNDPLYN +G KG+ G + ++EQLI +L++ H+ + + E N T Q T+ D +++ +P C EC + + + +++LHA++Y+ V W+Y T++P W Sbjct: 106 EANSLKT----KRPGFSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRF---PDGIVECNEKIDVVSYKIGVCKVSP-----KGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLYNHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLGLEGDQIVSGEIKDVAASTSVVEAPSVVQAPINSETEKPVISKNLEPSNDATAQIATQTCYEEPDRSFDSKKTTSDPQCSECKINYR-DPGTKDLIMYLHAWKYKGV--GWEYETELPEWA 537
BLAST of Pseudouridine synthase vs. Ensembl Fly
Match: RluA-2 (gene:FBgn0032256 transcript:FBtr0080032) HSP 1 Score: 268.085 bits (684), Expect = 3.491e-83 Identity = 157/447 (35.12%), Postives = 240/447 (53.69%), Query Frame = 2 Query: 170 EALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCG-VYHKSKEQLIEDLMANHDVS-------------------------------------------VHRFYENGNPETLQTFTENKSIISDE--EARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 EA KT K SD+ + YYF+NG RKV+PYF TF + K RW+++ + +VF +F + P + +E L +N+++ DY +K ND++ + VHRHE+PV +PIKI++ ++VV KP+S+PVH +Y NTV+ IL K H ++ LR IHR+DR+TSG+LLFG+ E + +L QIR RQV K Y+ V G+F + +EC + + ++ K+G+ V K K F + E + S+VLCKPLTGR HQIRVHLQ+LG+PISNDPLYN +G KG+ G + ++EQLI +L++ H+ + + E N T Q T+ D +++ +P C EC + + + +++LHA++Y+ V W+Y T++P W Sbjct: 106 EANSLKT----KRPGFSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRF---PDGIVECNEKIDVVSYKIGVCKVSP-----KGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLYNHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLGLEGDQIVSGEIKDVAASTSVVEAPSVVQAPINSETEKPVISKNLEPSNDATAQIATQTCYEEPDRSFDSKKTTSDPQCSECKINYR-DPGTKDLIMYLHAWKYKGV--GWEYETELPEWA 537
BLAST of Pseudouridine synthase vs. Ensembl Fly
Match: RluA-2 (gene:FBgn0032256 transcript:FBtr0304133) HSP 1 Score: 266.544 bits (680), Expect = 1.015e-82 Identity = 159/443 (35.89%), Postives = 239/443 (53.95%), Query Frame = 2 Query: 170 EALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCG-VYHKSKEQLIEDLMANHDVSVHRFYENGN------------------PETLQ----TFTENKSIISDEEARNKYF-------------------EPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 EA KT K SD+ + YYF+NG RKV+PYF TF + K RW+++ + +VF +F + P + +E L +N+++ DY +K ND++ + VHRHE+PV +PIKI++ ++VV KP+S+PVH +Y NTV+ IL K H ++ LR IHR+DR+TSG+LLFG+ E + +L QIR RQV K Y+ V G+F + +EC + + ++ K+G+ V K K F + E + S+VLCKPLTGR HQIRVHLQ+LG+PISNDPLYN +G KG+ G + ++EQLI +L++ H+ E P +Q + TE I + E N +P C EC + + + +++LHA++Y+ V W+Y T++P W Sbjct: 106 EANSLKT----KRPGFSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRF---PDGIVECNEKIDVVSYKIGVCKVSP-----KGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLYNHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLGLEGDQIVSGEIKDVAASTSVVEAPSVVQAPINSETEKPVISKNLEPSNDIATQTCYEEPDRSFDSKKTTSDPQCSECKINYR-DPGTKDLIMYLHAWKYKGV--GWEYETELPEWA 533
BLAST of Pseudouridine synthase vs. Ensembl Fly
Match: RluA-1 (gene:FBgn0051719 transcript:FBtr0080040) HSP 1 Score: 251.906 bits (642), Expect = 2.559e-75 Identity = 136/325 (41.85%), Postives = 204/325 (62.77%), Query Frame = 2 Query: 161 FRKEALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCG-VYHKSKEQLIEDLMANHDV 1132 +K L+ K + K+ ++YQ + YY +NG RKV+PY+ TF + K RW+ + + ++F +F ++ + I+ L +N ++ +DY LK ND++ + VHRHE+PV +PIKI+H + ++VV KP+S+PVH +Y NTV+ IL K ++ LR IHR+DR+TSG+LLFG+ + + ++ QIR+RQV K Y+ V G F + +ECK+ + ++ K+G+ V + GK +T F L N S+VLCKPLTGR HQIRVHLQYLG+PI NDPLYN +G KG+ G + KS E+LI DL+ H+ Sbjct: 261 LKKAKLETKALKAKRPGFTDERYQ-ETSYYMENGLRKVYPYYFTFTTFTKGRWVGEKILDIFSREFRAHPAEEYERCIQTGTLTVNFEKVPIDYRLKHNDLLANIVHRHEVPVTCQPIKIVHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEFNLKNLRTIHRLDRLTSGLLLFGRSPKKARQMEQQIRNRQVEKEYICRVEGVFPDGI---VECKEPIEVVSYKIGVCKVSA---KGKDCTTTFQKLSQN--GTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLYNHEVFGPLKGRSGDIGGKSDEELIRDLINIHNA 576
BLAST of Pseudouridine synthase vs. Ensembl Fly
Match: RluA-1 (gene:FBgn0051719 transcript:FBtr0080039) HSP 1 Score: 251.906 bits (642), Expect = 2.559e-75 Identity = 136/325 (41.85%), Postives = 204/325 (62.77%), Query Frame = 2 Query: 161 FRKEALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCG-VYHKSKEQLIEDLMANHDV 1132 +K L+ K + K+ ++YQ + YY +NG RKV+PY+ TF + K RW+ + + ++F +F ++ + I+ L +N ++ +DY LK ND++ + VHRHE+PV +PIKI+H + ++VV KP+S+PVH +Y NTV+ IL K ++ LR IHR+DR+TSG+LLFG+ + + ++ QIR+RQV K Y+ V G F + +ECK+ + ++ K+G+ V + GK +T F L N S+VLCKPLTGR HQIRVHLQYLG+PI NDPLYN +G KG+ G + KS E+LI DL+ H+ Sbjct: 261 LKKAKLETKALKAKRPGFTDERYQ-ETSYYMENGLRKVYPYYFTFTTFTKGRWVGEKILDIFSREFRAHPAEEYERCIQTGTLTVNFEKVPIDYRLKHNDLLANIVHRHEVPVTCQPIKIVHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEFNLKNLRTIHRLDRLTSGLLLFGRSPKKARQMEQQIRNRQVEKEYICRVEGVFPDGI---VECKEPIEVVSYKIGVCKVSA---KGKDCTTTFQKLSQN--GTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLYNHEVFGPLKGRSGDIGGKSDEELIRDLINIHNA 576
BLAST of Pseudouridine synthase vs. Ensembl Zebrafish
Match: rpusd2 (RNA pseudouridine synthase domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-120411-43]) HSP 1 Score: 233.417 bits (594), Expect = 2.094e-69 Identity = 152/453 (33.55%), Postives = 242/453 (53.42%), Query Frame = 2 Query: 200 KKNKIIS--DQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETN-LDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGV--------------YHKSKEQLIEDLMANHDVSVHRFYENG-------------------------NPETLQTFTE--------------NKSIISDEEA---RNKYF--EPSCDEC-LSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 K+N +S ++ + YYF+ G RKVHPY+ F+S K RW+ K++ +VF+ +F + S + + ++ + +N + L+ +LK ND++ + VHRHE PV +P+K++ + V+VV KPSS+PVH +Y NTV+ IL K G+ L +HR+DR+TSG+LLF + E S KL +R+RQ+ K Y+ V G+F E + + C++ + ++ +VGL V+ GK + T F L +N + S+V C+PLTGRTHQIRVHLQ+LGFPI NDP+Y +WG ++ K G+ H+SKE L + + +VS ++G E+ Q + +K + SD+ + R+K F + C EC + R E +++LHA RY+ D++Y T +P+W Sbjct: 144 KRNTGVSFNQEHFAETSYYFEGGLRKVHPYYFDFKSYCKGRWIGKTLLDVFKKEFRAESLDYYNAAVKEGRIKLNETPVDDLNVVLKNNDLLRNTVHRHEPPVCGQPLKLLVDDGEVVVVDKPSSLPVHPCGRYRHNTVIFILGKEKGLVGLHTVHRLDRLTSGVLLFARTLEVSKKLDVMVRERQLEKEYVCRVEGEFPEAE---VVCEEPILVVSFRVGLC---RVDPKGKESRTIFQRLSFNGRS--SVVRCRPLTGRTHQIRVHLQFLGFPILNDPIYGSSAWGPNRAKGGLVGMSDEELLEALIEEHRSKESLHLLDLPDEEVSGKTKCKDGAQGRNEQITAIESSSGSSEVSLDEVKAESRQVVQQSTSESVGEINGARKDKDLASDDASRTGRSKDFVRDHLCGECKIVRPDPTE--KELIMYLHALRYK--GPDFEYSTQLPDWA 584
BLAST of Pseudouridine synthase vs. Ensembl Zebrafish
Match: rpusd1 (RNA pseudouridine synthase domain containing 1 [Source:NCBI gene;Acc:767786]) HSP 1 Score: 62.7734 bits (151), Expect = 2.194e-10 Identity = 57/197 (28.93%), Postives = 88/197 (44.67%), Query Frame = 2 Query: 494 PVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQL---------RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLG--ILCPKVGLAYVKSVE--EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYN 1039 P E + ++++S +VV K + + S Y TV L H +L R H++D TSG L + + + +DR+V K YLA+V G EE + ++G K + + E E K T+ L+Y + ++ VL +PLTGRTHQ+RVH +G PI D Y+ Sbjct: 3 PASLENLCVLYQSTNYIVVNKHWDIRIDSKMWYEKQTVQSQL--KHRFPELADPGTYYGFRFCHQLDFSTSGALCVALNKAAAGQAYRCFKDRRVTKAYLALVRGTVTEEN---LSLDFAIGKNTTEGKTHMMCTEGTEGCENPKPCQTEVTVLEYGTYDGDPVTKVLLQPLTGRTHQLRVHCSAIGHPIVGDYTYS 194
BLAST of Pseudouridine synthase vs. Ensembl Zebrafish
Match: rpusd1 (RNA pseudouridine synthase domain containing 1 [Source:NCBI gene;Acc:767786]) HSP 1 Score: 62.7734 bits (151), Expect = 2.194e-10 Identity = 57/197 (28.93%), Postives = 88/197 (44.67%), Query Frame = 2 Query: 494 PVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQL---------RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLG--ILCPKVGLAYVKSVE--EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYN 1039 P E + ++++S +VV K + + S Y TV L H +L R H++D TSG L + + + +DR+V K YLA+V G EE + ++G K + + E E K T+ L+Y + ++ VL +PLTGRTHQ+RVH +G PI D Y+ Sbjct: 3 PASLENLCVLYQSTNYIVVNKHWDIRIDSKMWYEKQTVQSQL--KHRFPELADPGTYYGFRFCHQLDFSTSGALCVALNKAAAGQAYRCFKDRRVTKAYLALVRGTVTEEN---LSLDFAIGKNTTEGKTHMMCTEGTEGCENPKPCQTEVTVLEYGTYDGDPVTKVLLQPLTGRTHQLRVHCSAIGHPIVGDYTYS 194
BLAST of Pseudouridine synthase vs. Ensembl Xenopus
Match: RPUSD2 (RNA pseudouridylate synthase domain containing 2 [Source:NCBI gene;Acc:100497757]) HSP 1 Score: 251.136 bits (640), Expect = 4.863e-77 Identity = 153/432 (35.42%), Postives = 228/432 (52.78%), Query Frame = 2 Query: 218 SDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKET--NLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNK-YFEPS--------------------------------------------CDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 D++ + Y +NG RKV PY+ F++ K RW+ KS+ EVF +F + PL Q L N+ET +L+ +LK ND + + VHRHE PV EP++I+ E+D ++V+ KPSS+PVH ++ NTV+ IL K + ++ L IHR+DRMTSG+L+F K E S K+ Q+R RQ+ K Y+ V G+F +E+ + C++ + ++ K+G+ V+ GK T F L YN K S+V C P TGRTHQIRVHLQYLG PI NDP+YN +WG ++GK G +++ E L+ L+ H + + E LQ EN + S E K EP+ C EC + + V++LHA RY+ ++D+ +D+P+W Sbjct: 71 GDEHFRETETYLENGLRKVRPYYFDFETYCKGRWVGKSLLEVFGKEFRA-EPLEYYEQAAQAGRLRLNEETVRDLNVVLKNNDFLRNTVHRHEPPVTAEPLRILAENDEMVVIDKPSSLPVHPCGRFRHNTVIFILGKEYNLKGLHTIHRLDRMTSGVLMFAKTLEVSKKIDEQVRQRQLEKEYVCRVCGEFPKEE---VTCEEPIFVVSYKIGVC---RVDPKGKPCKTVFQRLSYNGKS--SVVKCFPYTGRTHQIRVHLQYLGHPIVNDPIYNTEAWGPNRGKGGEINRTDEDLLRALVDVHKSKQSLDILDISEEDLQPIMENAGLKSSTEPVQKEASEPADPQPKDEAQECKLTENVTNSSQDTDSSAACRITEESSQGSRDSLCGECRI-VRADPSPKDLVMYLHALRYKGA--EFDFSSDMPDWA 490
BLAST of Pseudouridine synthase vs. Ensembl Xenopus
Match: RPUSD1 (RNA pseudouridine synthase domain containing 1 [Source:NCBI gene;Acc:100380010]) HSP 1 Score: 70.4774 bits (171), Expect = 7.701e-13 Identity = 63/199 (31.66%), Postives = 93/199 (46.73%), Query Frame = 2 Query: 494 PVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQL---------RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGI-LCPKVGLAYVKSVE-----EGGKIASTKFMFLKYNEKQN--LSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYN 1039 P E + I+++S LVV K + + S Y TV L H +L R H++D TSG L + E + + +DR V K YLA+V G +E+ + SL I + GL ++ VE + K T + L++ + ++ VL +PLTGRTHQ+RVH LGFPI D Y+ Sbjct: 3 PCSIEKLSILYQSADFLVVNKHWDIRIDSKMWYEKLTVQSQL--KHRFPELADPGTYYGFRFCHQLDFSTSGALCVALNKEAAGRAYQCFKDRTVTKAYLALVRGTVSEKY-----MRISLAIGKNTQEGLTHMMCVEGAPGCKNAKPCQTDLVVLQHGSYKGDPVTKVLLQPLTGRTHQLRVHCSALGFPIVGDFTYS 194
BLAST of Pseudouridine synthase vs. Ensembl Mouse
Match: Rpusd2 (RNA pseudouridylate synthase domain containing 2 [Source:MGI Symbol;Acc:MGI:1918066]) HSP 1 Score: 261.536 bits (667), Expect = 1.574e-80 Identity = 153/423 (36.17%), Postives = 235/423 (55.56%), Query Frame = 2 Query: 218 SDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKET-NLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANH----DVSVHRFYENG-NPETLQTFTENKSIISDE---------------EARNKYF---------------EPSCDEC--LSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 SD++ + YYF+ G RKV PY+ FQ+ K RW+ +S+ VF +F S + ++ + L +N + +L +LK ND + + VHRHE PV EPI ++ E++ V+V+ KPSS+PVH ++ NTV+ IL K H +++L +HR+DR+TSG+L+F K S K+ Q+RDRQ+ K Y+ V+G+F +++ + CK+ + ++ KVG V V+ GK T F L YN + S+V C+PLTGRTHQIRVHLQ+LG PI NDP+YN +WG +G+ G K+ E+L+ DL+A H +S+ E+ P + + + + D EA ++ +P C EC L + +D V+FLHA RY+ D++Y + IP W Sbjct: 137 SDEHFAETTYYFEGGLRKVRPYYFDFQTYCKGRWVGRSLLHVFSTEFRSQPLSYYEAAVRAGRLHLNEEPVQDLSIVLKDNDFLRNTVHRHEPPVTAEPIHLLAENNDVVVIDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSEKIHEQVRDRQLEKEYVCRVAGEFPDKE---VICKEPILVVSYKVG---VCRVDPRGKPCETVFQRLSYNGRS--SVVQCRPLTGRTHQIRVHLQFLGHPILNDPIYNSTAWGPSRGQGGHIPKTDEELLRDLVAEHQAKESLSMLDLCESDLTPGLIDSTAPSSELAKDSLEGLATAAQKIDGIAEAAPQHLDTPEKAAKADVTQETDPLCAECRVLRQDPLPQD---LVMFLHALRYK--GPDFEYVSPIPAWA 546
BLAST of Pseudouridine synthase vs. Ensembl Mouse
Match: Rpusd1 (RNA pseudouridylate synthase domain containing 1 [Source:MGI Symbol;Acc:MGI:1919186]) HSP 1 Score: 61.6178 bits (148), Expect = 5.556e-10 Identity = 59/227 (25.99%), Postives = 95/227 (41.85%), Query Frame = 2 Query: 647 RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE-----EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFL 1306 R H++D TSG L + + ++R+V K YLA+V G E + + ++G + G + +E E K + T+ + L++ +S VL KPLTGRTHQ+RVH LG PI D Y G ++Q ++ H FY L+ T+ + + E F P+ D C S +C + ++ + L Sbjct: 61 RFCHQLDFSTSGALCVALNKAAAGSAYKCFKERRVTKAYLALVRGHVQESQ---VTINYAIGRNSTE-GRTHTMCIEGTHGCENPKPSLTELLVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPIVGDLTY------------GQAEDQEDQPFRMML-------HAFY-------LRIPTQAERV---EACTPDPFLPALDACWSPSTCVQPLEQLIQAL 254
BLAST of Pseudouridine synthase vs. Ensembl Mouse
Match: Rpusd1 (RNA pseudouridylate synthase domain containing 1 [Source:MGI Symbol;Acc:MGI:1919186]) HSP 1 Score: 61.6178 bits (148), Expect = 5.556e-10 Identity = 59/227 (25.99%), Postives = 95/227 (41.85%), Query Frame = 2 Query: 647 RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE-----EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFL 1306 R H++D TSG L + + ++R+V K YLA+V G E + + ++G + G + +E E K + T+ + L++ +S VL KPLTGRTHQ+RVH LG PI D Y G ++Q ++ H FY L+ T+ + + E F P+ D C S +C + ++ + L Sbjct: 61 RFCHQLDFSTSGALCVALNKAAAGSAYKCFKERRVTKAYLALVRGHVQESQ---VTINYAIGRNSTE-GRTHTMCIEGTHGCENPKPSLTELLVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPIVGDLTY------------GQAEDQEDQPFRMML-------HAFY-------LRIPTQAERV---EACTPDPFLPALDACWSPSTCVQPLEQLIQAL 254
BLAST of Pseudouridine synthase vs. Ensembl Mouse
Match: Rpusd4 (RNA pseudouridylate synthase domain containing 4 [Source:MGI Symbol;Acc:MGI:1919239]) HSP 1 Score: 52.373 bits (124), Expect = 8.021e-7 Identity = 54/195 (27.69%), Postives = 91/195 (46.67%), Query Frame = 2 Query: 515 KIIHESDTVLVVCKPSSMPVHSVSKYHF--NTVMGILHK---SHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAV---VSGKFNEEKEQPIECKKSLG-------ILCPKVGLAYVKSVE----EGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQY-LGFPISNDPLYN 1039 +I+H+ + ++V+ KP +PVH + V+ IL K H + L + HR+D+ T+G+++ + + + ++ R RQV K Y A+ V + PI+ K+ G L P L K V+ +A T++ L L + +P+TG HQ+RVHL + L PI D Y+ Sbjct: 98 RILHQDNDLVVINKPYGLPVHGGPGVQLCISDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWEKDMAHQVQELFRTRQVEKKYWAITVRVPLPSAGVVDIPIKEKEVQGPQQHHKMTLSPSYRLDNGKMVKVRASRDAHVAVTQYQVLSSASSSALVEL--QPVTGIKHQLRVHLSFGLDCPILGDHKYS 290
BLAST of Pseudouridine synthase vs. UniProt/SwissProt
Match: sp|Q8IZ73|RUSD2_HUMAN (RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2) HSP 1 Score: 261.922 bits (668), Expect = 5.975e-80 Identity = 148/427 (34.66%), Postives = 229/427 (53.63%), Query Frame = 2 Query: 218 SDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKET-NLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHD--------------------------------------VSVHRFYE--NGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 D++ + YYF+ G RKV PY+ F++ K RW+ S+ VF +F + + ++ + L +N K +L+ +LK ND + + VHRHE PV EPI+++ E++ V+VV KPSS+PVH ++ NTV+ IL K H +++L +HR+DR+TSG+L+F K S ++ Q+RDRQ+ K Y+ V G+F E+ + CK+ + ++ KVG V V+ GK T F L YN + S+V C+PLTGRTHQIRVHLQ+LG PI NDP+YN ++WG +G+ G K+ E+L+ DL+A H + + E P+ L T + + N+ +P C EC R + + + V+FLHA RY+ ++Y + +P W Sbjct: 124 GDEHFAETSYYFEGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEAAVRAGRLQLNEKPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEE---VTCKEPILVVSYKVG---VCRVDPRGKPCETVFQRLSYNGQS--SVVRCRPLTGRTHQIRVHLQFLGHPILNDPIYNSVAWGPSRGRGGYIPKTNEELLRDLVAEHQAKQSLDVLDLCEGDLSPGLTDSTAPSSELGKDDLEELAAAAQKMEEVAEAAPQELDTIALASEKAVETDVMNQETDPLCAEC--RLVRQDPLPQDLVMFLHALRYK--GPGFEYFSPMPAWA 538
BLAST of Pseudouridine synthase vs. UniProt/SwissProt
Match: sp|Q149F1|RUSD2_MOUSE (RNA pseudouridylate synthase domain-containing protein 2 OS=Mus musculus OX=10090 GN=Rpusd2 PE=1 SV=2) HSP 1 Score: 261.536 bits (667), Expect = 1.101e-79 Identity = 153/423 (36.17%), Postives = 235/423 (55.56%), Query Frame = 2 Query: 218 SDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKET-NLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANH----DVSVHRFYENG-NPETLQTFTENKSIISDE---------------EARNKYF---------------EPSCDEC--LSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 SD++ + YYF+ G RKV PY+ FQ+ K RW+ +S+ VF +F S + ++ + L +N + +L +LK ND + + VHRHE PV EPI ++ E++ V+V+ KPSS+PVH ++ NTV+ IL K H +++L +HR+DR+TSG+L+F K S K+ Q+RDRQ+ K Y+ V+G+F +++ + CK+ + ++ KVG V V+ GK T F L YN + S+V C+PLTGRTHQIRVHLQ+LG PI NDP+YN +WG +G+ G K+ E+L+ DL+A H +S+ E+ P + + + + D EA ++ +P C EC L + +D V+FLHA RY+ D++Y + IP W Sbjct: 137 SDEHFAETTYYFEGGLRKVRPYYFDFQTYCKGRWVGRSLLHVFSTEFRSQPLSYYEAAVRAGRLHLNEEPVQDLSIVLKDNDFLRNTVHRHEPPVTAEPIHLLAENNDVVVIDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSEKIHEQVRDRQLEKEYVCRVAGEFPDKE---VICKEPILVVSYKVG---VCRVDPRGKPCETVFQRLSYNGRS--SVVQCRPLTGRTHQIRVHLQFLGHPILNDPIYNSTAWGPSRGQGGHIPKTDEELLRDLVAEHQAKESLSMLDLCESDLTPGLIDSTAPSSELAKDSLEGLATAAQKIDGIAEAAPQHLDTPEKAAKADVTQETDPLCAECRVLRQDPLPQD---LVMFLHALRYK--GPDFEYVSPIPAWA 546
BLAST of Pseudouridine synthase vs. UniProt/SwissProt
Match: sp|Q09709|YA32_SCHPO (Uncharacterized protein C18B11.02c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC18B11.02c PE=3 SV=1) HSP 1 Score: 229.18 bits (583), Expect = 4.503e-69 Identity = 133/391 (34.02%), Postives = 208/391 (53.20%), Query Frame = 2 Query: 236 DCVYYFQ-NGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLY-NCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPS----------CDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 DC Y F+ +G R+V PY++ + + K RW K++ EVF +F + + I N + +NN+ N+D +++ +++H HRHE PV D+P+ I+HE ++ +V+ KP+ +PVH +Y+ NTV+ IL K + L +R+DR+TSG++ F K + + ++ + + + K Y+A V G+F E + C L + P +GL + GK AST F + ++ + SLVLCKPLTGRTHQ+RVHLQYLG+PI+NDP+Y N WG GK G S E +I R E G ET + + ++ EA K C EC + + + ++LHA +Y + DW Y+T +P W Sbjct: 12 DCEYVFKGDGLRRVPPYYYEYITFAKLRWYGKTLLEVFNTEFRDRESGYYEKAIRNGQVKVNNQIGNVDTLIENGYIVSHHAHRHEPPVSDQPVGIVHEDESYVVIDKPAGVPVHPTGRYNHNTVLHILMKENKCSLLYPCNRLDRLTSGLMFFSKSPKAAEEMRVHMISKSLKKEYVARVIGEFPNSGE--VICDAPLLTVAPTLGL---NRIHPDGKEASTVFKRIAFD--GHTSLVLCKPLTGRTHQLRVHLQYLGYPIANDPIYANKRVWGPSLGKNG--EGSNESVI-----------MRLSEIGKTETASPLLQYEWYTNETEAEAKARRDKRLGELLTGKHCSECGTPLYSDPSPEELGIWLHALKYES--KDWSYKTQLPKWA 380
BLAST of Pseudouridine synthase vs. UniProt/SwissProt
Match: sp|Q12362|RIB2_YEAST (Bifunctional protein RIB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=RIB2 PE=1 SV=1) HSP 1 Score: 233.032 bits (593), Expect = 2.141e-68 Identity = 137/389 (35.22%), Postives = 208/389 (53.47%), Query Frame = 2 Query: 263 FRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPI---ECKKSLGILCPKVGL-AYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLY-NCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTD-------WDYRTDIPNWVGLFALSP 1393 RK+ PYF T+++ KERW ++ + +VF ++F P + I + +N++ NLD I++ D+ITH+VHRHE PV +PI I+ E + +LV+ KPSS+PVH +Y FNT+ +L + G + +R+D+ TSG++ K + ++ Q++ R+V K Y+A V G+F PI E K + + PKV L A + +E K A T F + Y+ + S+V CKPLTGRTHQIRVHLQYLGFPI+NDP+Y N WG D G+ G + N+D V + + + +S I C+EC + + ++ L+LHA+RY +++ + W YRT P W AL P Sbjct: 78 LRKIEPYFFTYKTFCKERWRDRKLVDVFVSEFRDREPSYYSKTIAEGKVYLNDEPANLDTIIRDGDLITHKVHRHEPPVTSKPIDIVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLGY-SVHPCNRLDKPTSGLMFLAKTPLGADRMGDQMKAREVTKEYVARVKGEF------PIGIVEVDKPVRSVNPKVALNAVCEMSDENAKHAKTVFQRVSYDGQT--SIVKCKPLTGRTHQIRVHLQYLGFPIANDPIYSNPDIWGPDLGRGG-------------LQNYDDIVLKL------DAIGKTNPAESWIHPHSEGEYLLGRQCEECEAEMYTDPGTNDLDLWLHAFRYESLERNSDTQKPLWSYRTKYPEW----ALEP 434
BLAST of Pseudouridine synthase vs. UniProt/SwissProt
Match: sp|O16686|YK27_CAEEL (Uncharacterized protein K07E8.7 OS=Caenorhabditis elegans OX=6239 GN=K07E8.7 PE=3 SV=1) HSP 1 Score: 226.868 bits (577), Expect = 8.887e-68 Identity = 130/382 (34.03%), Postives = 210/382 (54.97%), Query Frame = 2 Query: 257 NGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKE-TNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTF----TENKSIISDEEARNKYFEPSCDECLSRFSCNEDV-----DNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 +G R + PY+ +++ K RW+ + + EVF +F S + + K + + +N ++ T++DY+++ D + H HRHE P+ D PI++I E+D + VV KP S+PVH+ +Y +TV+G L + G LRV+HR+DR TSG+LLF K+YET + ++ + K Y+ V G F +E++ C++ +G L +G ++ V GK A ++F L + Q++ V + TGRTHQIRVH Q+LG PI+ D +YN WG KGK Y KS ++L ED+ H ++E NPE Q + I + + P DE + CN + ++F L+LH +Y T W ++T++P+W Sbjct: 62 DGVRHLAPYWACYRTRTKGRWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVDYVMRNGDRVEHWAHRHEHPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDRATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQV---CEQPIGPLVISMG---IQCVRPDGKDAKSRFRKLWSDGTQSVVQVHIE--TGRTHQIRVHSQFLGHPIAGDQIYNSAVWGPTKGKNADYQKSFDELCEDVRNTH--KCENWHEKPNPEFEQRMEHLAADTTPITPEAPSLTLEQRPEFDEICQK--CNVESKKVPENHFQLYLHCLKYET--KKWSFKTEMPDWA 429
BLAST of Pseudouridine synthase vs. TrEMBL
Match: A0A3R7D786 (RNA pseudouridylate synthase domain-containing protein 2 OS=Clonorchis sinensis OX=79923 GN=Rpusd2 PE=4 SV=1) HSP 1 Score: 311.997 bits (798), Expect = 7.999e-97 Identity = 182/482 (37.76%), Postives = 275/482 (57.05%), Query Frame = 2 Query: 32 FAPVKKISYLNIIDIITMKRLSKNMED-FXXXXXXXXXXXXXXLFRKEALKFKTGENKKNKIISDQYQGDCV--YYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQP--------IECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIIS------DEEARNKY---FEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSPTDKDTLIN 1417 FA +K L ++ L ME F +K K SKEEKKL +K A + + E K++ Y+ + YYF+NG RKV PY F++ +K RW+++ + EV ++F P + ++ ++ +L +N++ + DY+L+ +D+I+H+VHRHE+PVLD PI IHE D +LV+ KP+S+PVH +Y N++ IL + + + LR HR+DRMTSG+++ K+Y+ S +L+ +I R+V KYY+ V G F +E E I C + LG LC K+GL V S GGK A T F L Y+ N SLV+C+ TGRTHQIR+HLQYLG+PI++DPLYN WG KGK Y +++I + A+ + + +G ++ F + ++ D+E R++ F+ +C EC+ RF + D+ VL LHAYRY DW Y +P+W A +D LI Sbjct: 43 FAGFRKTEKLRMVHRTLAHCLQDPMETVFPKTKIPKCSKEEKKLLQKAAARSRRQERKRSLEDFLHYESINISDYYFENGLRKVFPYHFMFKAYVKRRWIDRPIHEVLLDEFNFPFPDIIHARCDSGDLRVNDECISPDYLLRDSDMISHKVHRHEMPVLDSPIDFIHEDDDLLVINKPASIPVHPCGQYTLNSLTHILARQYDRRPLRFTHRLDRMTSGLMIIAKNYDASLRLATEISAREVKKYYICRVDGHFPDEVEDSPSTLPQGVIACTQPLGPLCSKMGLHAVVSESSGGKPACTHFKRLLYDPDTNTSLVVCRLFTGRTHQIRIHLQYLGYPITDDPLYNSSDWGDRKGKGAQYGVPVDEVIRRISAHRSKDSYLDFVHGTESSISGFDRLRDHLNSTRSALDKEVRDRLLQSFDSTCPECI-RFYKDPDMKCLVLQLHAYRYEGA--DWSYTASLPSWATSLASHTSDFPALIQ 521
BLAST of Pseudouridine synthase vs. TrEMBL
Match: A0A1S8X9Q7 (Pseudouridine synthase OS=Opisthorchis viverrini OX=6198 GN=X801_00666 PE=3 SV=1) HSP 1 Score: 305.064 bits (780), Expect = 7.446e-95 Identity = 164/440 (37.27%), Postives = 255/440 (57.95%), Query Frame = 2 Query: 158 LFRKEALKFKTGENKKNKIISDQYQGDCV--YYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVK-SQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQP--------IECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIIS------DEEARNKY---FEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSPTDKDTLIN 1417 L +K A + + E K++ Y+ + YYF+NG RKV PY F++ +K RW+++S+ EV ++F P +K ++ ++ +L +N++ + DY+L+ +D+I+H+VHRHE+PVLD PI IHE D +LV+ KP+S+PVH +Y N++ IL K + + LR HR+DRMTSG+++ K+Y+ S +L+ +I R+V KYY+ G F +E E I C + LG +C K+GL V GGK A T F L Y+ N SLV+C+ TGRTHQIR+HLQYLG+PI++DPLYN WG KGK Y +++I + + + + +G + F + + ++ D+E R++ F+ +C EC +RF + D+ + VL LHAYRY +W Y +P+W A +D LI Sbjct: 33 LLQKAAARSRKQERKRSLEDFLHYESIDISDYYFENGLRKVFPYHFMFKAYVKRRWIDRSIHEVLLDEFNFPFPDIIKHARCDSGDLRVNDERISPDYLLRDSDMISHKVHRHEMPVLDSPIDFIHEDDDLLVINKPASIPVHPCGQYTLNSLTHILAKQYDRRPLRFTHRLDRMTSGLMIVAKNYDASLRLATEIGAREVKKYYICRADGHFPDEVEDTPNTLPQGVIACTQPLGPICSKMGLHAVVPESSGGKPACTHFKRLLYDSNTNTSLVVCRLFTGRTHQIRIHLQYLGYPITDDPLYNSSDWGDKKGKGAQYGIPVDEVIRKISTHRSKDSYLDFVHGTESNISGFDKFRDHLNSTHSALDKEVRDRLLQSFDSTCPEC-NRFYKDPDMKSLVLQLHAYRYEGA--EWSYTASLPSWATRLASHTSDFPALIQ 469
BLAST of Pseudouridine synthase vs. TrEMBL
Match: A0A5J4NEE2 (Pseudouridine synthase OS=Paragonimus westermani OX=34504 GN=DEA37_0013999 PE=3 SV=1) HSP 1 Score: 304.294 bits (778), Expect = 1.573e-94 Identity = 164/401 (40.90%), Postives = 239/401 (59.60%), Query Frame = 2 Query: 245 YYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPL--FVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQP--------IECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIIS-----DEEARNKY---FEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSP 1393 YYF+NGFRKV+PY F+S K RWL +S+ +V +F N PL + + + +L +N+ +YIL+ +D+I+H+VHRHELPVL+ PIK +HE D VLV+ KP+S+PVH +Y N+++ IL K +G + LR IHR+DRMTSG+++ K+Y+ S +L+ QI R+V KYY+ V G+F + I C + LG +C K+GL V ++GGK + T F+ L YN SLVLC+ TGRTHQIRVHLQYLG+PI DPLYN WG+ KGK Y +++I + +N + + E+ ++F + K IS D + R++ F+ C +C + + D+ N VL LHAY+Y DW Y +P+W +SP Sbjct: 62 YYFENGFRKVYPYHFVFKSYAKRRWLGRSICDVLLEEF--NFPLQSVIPDRCLSGDLRVNDLPITPNYILQDSDLISHKVHRHELPVLNTPIKFVHEDDDVLVLSKPASIPVHPCGQYTLNSMVHILAKEYGRRPLRFIHRLDRMTSGLMITAKNYDASLRLTSQISAREVKKYYVCQVEGRFPDRLPNASQMCAPGVIACDQPLGPICAKLGLHAVVPEKDGGKASLTHFLRLAYNPLIKSSLVLCRLFTGRTHQIRVHLQYLGYPIVGDPLYNSTDWGEMKGKGAQYDIPLDEIIRRISSNRTAASYLNENQSFTESSRSFDQFKERISASNSLDSDTRDRLVRSFDHHCPDCRLCYR-DPDIRNLVLRLHAYQY--CGLDWSYVAPLPDWATGDMMSP 457
BLAST of Pseudouridine synthase vs. TrEMBL
Match: A0A4S2LZ79 (Pseudouridine synthase OS=Opisthorchis felineus OX=147828 GN=CRM22_004943 PE=3 SV=1) HSP 1 Score: 301.597 bits (771), Expect = 1.875e-93 Identity = 163/439 (37.13%), Postives = 249/439 (56.72%), Query Frame = 2 Query: 158 LFRKEALKFKTGENKKNKIISDQYQGDCV--YYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQP--------IECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIIS------DEEARN---KYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSPTDKDTLIN 1417 L +K A + + E K++ Y+ + YYF++G RKV PY F++ +K RW+++S+ EV ++F P + ++ ++ +L +N++ + DY+L+ +D+I+H+VHRHE+PVLD PI IHE +LV+ KP+S+PVH +Y N++ IL K + + LR HR+DRMTSG+++ K+Y+ S +L+ +I R+V KYY+ G F +E E I C + LG +C K+GL V GGK A T F L Y+ N SLV+C+ TGRTHQIR+HLQYLG PI++DPLYN WG KGK Y +++I + + + + +G + F + ++ D+E R+ K F+ +C EC +RF + D VL LHAYRY DW Y +P+W A +D LI Sbjct: 33 LLQKAAARSRKQERKRSLEDFLHYESIEISDYYFEDGLRKVFPYHFIFKAYVKRRWIDRSIHEVLLDEFNFPFPDIIHARCDSGDLRVNDECISPDYLLRDSDMISHKVHRHEMPVLDSPIDFIHEDSDLLVINKPASIPVHPCGQYTLNSLTHILAKQYDRRPLRFTHRLDRMTSGLMIIAKNYDASLRLATEISAREVKKYYICRADGHFPDEVEDSPGTLPQGVIACTQPLGPICSKMGLHAVVPESSGGKPACTHFKRLLYDPNTNTSLVVCRLFTGRTHQIRIHLQYLGHPITDDPLYNSSDWGVKKGKGAQYGMPLDEVIRKISTHRTKDSYLDFVHGTESNISGFDRFRDHLNSTRSALDKEVRDCLLKSFDSTCPEC-NRFYKDPDTKCLVLQLHAYRYEGA--DWSYTASLPSWATSLASHTSDLPALIQ 468
BLAST of Pseudouridine synthase vs. TrEMBL
Match: A0A553NBS4 (PseudoU_synth_2 domain-containing protein OS=Tigriopus californicus OX=6832 GN=TCAL_12503 PE=4 SV=1) HSP 1 Score: 304.294 bits (778), Expect = 1.927e-93 Identity = 158/400 (39.50%), Postives = 243/400 (60.75%), Query Frame = 2 Query: 191 GENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVS---VHRFYENGNPETLQTF-TENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGL 1378 G N + SD+ + YYF G R+V+PY TF + K RW+ + + +VF +F + +P IE+ ++LIN + T DY+L+ ND++ + VHRHE+PV D+ ++IIH+ ++VV KP+S+PVH +Y N+++ IL K ++ L IHR+DR+TSG+LL G++ + + QIR R VLK Y+ V G+F E+ + C++ + IL K+G+ V+ GK T+F ++ N ++ S+V CKP TGR HQIRVHLQ+LGFPI+NDPLYN ++G D+GK GV+ KS++QLI+DL+ H+ E+ P++++ T S S+ + R K P+C ECL ++ + D V+FLHA +Y DW Y T +P W L Sbjct: 178 GRNTRRSGFSDEKYDETSYYFAGGLRRVYPYAFTFATFAKRRWVGRPLMDVFATEFRAKTPPEYVRSIESGDILINGQPTTADYVLRDNDLLANTVHRHEVPVTDQRVQIIHQDQDLVVVNKPASIPVHPCGRYRHNSLVFILAKEFELKHLNTIHRLDRLTSGLLLLGRNPAIARTMEQQIRGRLVLKEYVCRVQGQFPAER---VVCREPIEILSHKIGIC---RVDPQGKACETEFELVQTNGQE--SVVRCKPHTGRMHQIRVHLQFLGFPITNDPLYNHEAFGPDRGKGGVFGKSQDQLIQDLIDAHNSERWLASASPEDAAPKSMKVMETPPNSSSSETDPRLKPV-PNCAECLVKYK-DPTADELVMFLHALKYS--GHDWSYETPLPAWSKL 565
BLAST of Pseudouridine synthase vs. Ensembl Cavefish
Match: rpusd2 (RNA pseudouridine synthase domain containing 2 [Source:NCBI gene;Acc:103042945]) HSP 1 Score: 234.958 bits (598), Expect = 6.108e-70 Identity = 129/314 (41.08%), Postives = 194/314 (61.78%), Query Frame = 2 Query: 197 NKKNKIIS--DQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPL--FVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANH 1126 K+N +S ++ + YYF+ G RKV PY+ F++ K RW+ K++ +VF +F + PL + K+ E + L +L+ LK ND + + VHRHE PV+ P++I+ + V+VV KP+S+PVH +Y NTV+ IL K G+ L +HR+DR+TSG+LLF + E S KL +RDRQ+ K Y+ V G+F + + + C++ + ++ KVG V V+ GK T F L YN + S+V C+PLTGRTHQIRVHLQ+LGFPI NDP+Y +WG ++GK GV + ++L+E L++ H Sbjct: 129 QKRNPAVSFTPEHFAETSYYFEAGLRKVRPYYFDFKTYCKGRWIGKTLLQVFSTEFRAE-PLDYYRKAAKEGRIRLNEEPVEDLNIRLKNNDFLRNTVHRHEPPVVGRPLEILVDDGEVVVVDKPASLPVHPCGRYRHNTVIFILGKERGLHALHTVHRLDRLTSGVLLFARTLEVSKKLDQMVRDRQLEKEYVCRVDGEFPDGE---VVCEEPILVVSFKVG---VCRVDPKGKDCRTVFQKLSYNGRS--SVVRCRPLTGRTHQIRVHLQFLGFPILNDPIYGASAWGPNRGKGGVVGVNDDELLEALISEH 433
BLAST of Pseudouridine synthase vs. Ensembl Cavefish
Match: rpusd1 (RNA pseudouridine synthase domain containing 1 [Source:NCBI gene;Acc:103042140]) HSP 1 Score: 59.3066 bits (142), Expect = 2.501e-9 Identity = 44/136 (32.35%), Postives = 65/136 (47.79%), Query Frame = 2 Query: 644 LRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE--EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYN 1039 R H++D TSG L + + + ++R V K YLA+V G EEK I+ K + V+ E E K + T+ L+Y + ++ VL +P TGRTHQ+RVH +G PI D Y+ Sbjct: 60 FRFCHQLDFSTSGALCVALNKAAAGRAYHFFKNRLVTKAYLALVRGSVPEEKLM-IDFAIGKNSTEGKTHMMCVEETEGCENPKPSQTELNVLEYGVYDGDPVTKVLLQPRTGRTHQLRVHCSAIGHPIVGDYTYS 194
BLAST of Pseudouridine synthase vs. Ensembl Sea Lamprey
Match: rpusd2 (RNA pseudouridine synthase domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-120411-43]) HSP 1 Score: 201.06 bits (510), Expect = 1.014e-60 Identity = 121/336 (36.01%), Postives = 174/336 (51.79%), Query Frame = 2 Query: 482 RHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAY---VKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANH-------------DVSVHRFYE----------NGNPETLQ----------TFTENKSIISDEEARNKYF---EPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 RHE PV P+ ++ ++D ++VV KPSSMPVH +Y NTV+ +L K HG+ L +HR+DR+TSG+LLF E +L QIR+R+V K YL V G+F + + + + P + ++Y V V+ GK T F L YN + S++LC+P TGR HQIRVHLQ+LG PI NDP+YN +WG + + G KS EQL++DL+A+ D V E +GN +T Q N+ + + EA + + +P C EC + + D ++FLHA RYR W+Y P W Sbjct: 1 RHEPPVAAGPVTLLAQTDELVVVDKPSSMPVHPCGRYRHNTVIFVLGKEHGLAPLHTVHRLDRLTSGVLLFAHTLEAVQRLDRQIREREVQKEYLCRVEGRFPGGEGE---EAEEVVCAEPVLVVSYSVGVCRVDTRGKPCRTTFTRLSYNGRS--SVLLCRPETGRMHQIRVHLQFLGHPILNDPVYNAAAWGPARARGGTIGKSDEQLLQDLLADRRRLGEEVTESCDGDCGVIGNGEGSIVGGGIACSGNDDTAQKSSAGSGGGDGGGTNEPVTTSSEAEDSWAGGQDPLCSEC-RQTRPDPRPDQLIMFLHALRYR--GPGWEYTAPTPEWA 328
BLAST of Pseudouridine synthase vs. Ensembl Sea Lamprey
Match: rpusd2 (RNA pseudouridine synthase domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-120411-43]) HSP 1 Score: 189.889 bits (481), Expect = 1.338e-55 Identity = 118/393 (30.03%), Postives = 193/393 (49.11%), Query Frame = 2 Query: 245 YYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNE---KQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHK--------SKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYF----EPSCDEC-LSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVG 1375 + RKV PY+ + K RWL S+++++E +F+S + ++ L +N + T+LD +L+ D I R HRHE PV P+ ++ E ++ V KP+S+PVH +Y +++ +L K G+ L +HR+DR+ SG+++F K E S ++ QIR R V K YL V G+F + + C++ L ++ ++G++ V + GK + + F L+Y+ SL+ C P+TGR+HQ+RVHLQ LGFPI DP+Y +W V + S L+E L A + + R S ++ E + +P C EC L R + + + LHA RY W + +P+W Sbjct: 21 FVLHGSLRKVRPYYADATARCKARWLGLSLRQLYEREFHSETVASYEAACAVGRLTLNGRRTHLDAVLRDGDTIRLRAHRHEPPVSSRPVVVVAEEHDLVAVDKPASLPVHPCGRYRHGSLLFVLGKERGVSGLHTLHRLDRLASGLVVFAKSREASRRVDEQIRQRLVHKEYLCRVVGEFPAGE---VVCEEPLSVVEGRLGVSRVDRL--AGKPSRSLFRRLRYDADTCAGGSSLLSCVPVTGRSHQLRVHLQSLGFPILLDPVYGSPAWANGAPLVDVLRRIADETCEPSARSLVERLGAADEWAWGRIPPG---PGGVRGGGGVSDVASEAVMAEVVWPEKDPICSECRLQRP--DPRPRDLGMCLHALRY--SGPGWGFEVPMPDWAA 401
BLAST of Pseudouridine synthase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009045.1 (pep scaffold:Pmarinus_7.0:GL484265:15078:19154:1 gene:ENSPMAG00000008183.1 transcript:ENSPMAT00000009045.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 68.1662 bits (165), Expect = 9.578e-13 Identity = 58/220 (26.36%), Postives = 94/220 (42.73%), Query Frame = 2 Query: 518 IIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGIL---------HKSH-------------GIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEK---EQPIECKKSLG--------ILCPK-----VGLAYVK-SVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQY-LGFPISNDPLYNCISWGK 1057 +IH+ ++VV KP +PVH N V +L H S +L + HR+DR T+G L+ ++ E + ++ +R+R+ + Y AV G + + P+ +K G + P+ A VK + G + A T++ L + +LV +PLTG HQ+RVHL LG P D Y+ G+ Sbjct: 41 VIHQQRELIVVNKPYGIPVHGGPGVGRNNVAAVLPVLEQLLDGHPSRRRHRKNTTAGDDATASKLHLCHRLDRDTTGALVLARNAEAADAVASLLRERRAERTYWAVTVGVPQPARGVVDLPVGERKHEGPDGVTYRMAVMPRFHYVDASNALVKRRLPRGARTAVTQYRVLAEGAEGRSALVELRPLTGHKHQLRVHLALGLGTPALGDHKYSPRRQGQ 260
BLAST of Pseudouridine synthase vs. Ensembl Yeast
Match: RIB2 (Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication [Source:SGD;Acc:S000005427]) HSP 1 Score: 233.032 bits (593), Expect = 3.083e-70 Identity = 137/389 (35.22%), Postives = 208/389 (53.47%), Query Frame = 2 Query: 263 FRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPI---ECKKSLGILCPKVGL-AYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLY-NCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTD-------WDYRTDIPNWVGLFALSP 1393 RK+ PYF T+++ KERW ++ + +VF ++F P + I + +N++ NLD I++ D+ITH+VHRHE PV +PI I+ E + +LV+ KPSS+PVH +Y FNT+ +L + G + +R+D+ TSG++ K + ++ Q++ R+V K Y+A V G+F PI E K + + PKV L A + +E K A T F + Y+ + S+V CKPLTGRTHQIRVHLQYLGFPI+NDP+Y N WG D G+ G + N+D V + + + +S I C+EC + + ++ L+LHA+RY +++ + W YRT P W AL P Sbjct: 78 LRKIEPYFFTYKTFCKERWRDRKLVDVFVSEFRDREPSYYSKTIAEGKVYLNDEPANLDTIIRDGDLITHKVHRHEPPVTSKPIDIVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLGY-SVHPCNRLDKPTSGLMFLAKTPLGADRMGDQMKAREVTKEYVARVKGEF------PIGIVEVDKPVRSVNPKVALNAVCEMSDENAKHAKTVFQRVSYDGQT--SIVKCKPLTGRTHQIRVHLQYLGFPIANDPIYSNPDIWGPDLGRGG-------------LQNYDDIVLKL------DAIGKTNPAESWIHPHSEGEYLLGRQCEECEAEMYTDPGTNDLDLWLHAFRYESLERNSDTQKPLWSYRTKYPEW----ALEP 434
BLAST of Pseudouridine synthase vs. Ensembl Yeast
Match: PUS9 (Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication [Source:SGD;Acc:S000002194]) HSP 1 Score: 223.787 bits (569), Expect = 5.353e-68 Identity = 132/379 (34.83%), Postives = 208/379 (54.88%), Query Frame = 2 Query: 263 FRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEE-GGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLY-NCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRY-------RTVDTDWDYRTDIPNWV 1372 RK+ PY T+++ KERW +K + +VF ++F + K IEN ++ IN++ +L +++ D+ITH+VHRHE PV PIK+I E D ++V+ KPS +PVH +Y FNT+ +L + G + +R+DR+TSG++ K + + + Q++ R+V K Y+A V G+F E + + +K L ++ P++ L V ++E G K A T F + Y+ K S+V CKPLTGR+HQIRVHLQYLG PI+NDP+Y N WG + GK G A+ D+ + + E G + +++ + + + K C C S + ++ L+LHAY Y T W Y+T+ P W Sbjct: 105 LRKIKPYHFTYRTFCKERWRDKKLVDVFISEFRDRESEYYKRTIENGDVHINDETADLSTVIRNGDLITHQVHRHEPPVTSRPIKVIFEDDNIMVIDKPSGIPVHPTGRYRFNTITKMLQNNLGF-VVNPCNRLDRLTSGLMFLAKTPKGADNIGDQLKAREVTKEYVAKVVGEFPETE---VIVEKPLKLIEPRLALNAVCQMDEKGAKHAKTVFNRISYDGK--TSIVKCKPLTGRSHQIRVHLQYLGHPIANDPIYSNDEVWGNNLGKGG-------------QADFDIVITKLDEIGKRKPAKSWFHSNGGYGEVLRQEK-----CSICESDLYTDPGPNDLDLWLHAYLYESTETEEGTEKKKWCYKTEYPEWA 459
BLAST of Pseudouridine synthase vs. Ensembl Yeast
Match: PUS6 (tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability [Source:SGD;Acc:S000003401]) HSP 1 Score: 157.918 bits (398), Expect = 6.607e-44 Identity = 119/412 (28.88%), Postives = 192/412 (46.60%), Query Frame = 2 Query: 248 YFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNL------DYILKPNDVITHRVHRHELPVL----------DEP-----IKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKF--------NEEKEQPI--ECKKSLGILCPKVGLAYVKSVEEG---GKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARN-KYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGL 1378 Y QNG RKV PY++ + +K RWL K + +V ++F + QI + L I+K +DV+ H+HE PV D P I+ E +++LV+ KPS +PVH +++ NT+ +L K HG+ L +R+D++TSG+L+ K+ +++ ++ IR R ++K YLA V G+F NE + + K + P + + G K A TKF ++Y + ++V CKP+TGRTHQIR+HL LG PI ND +Y C K E+L ++ +EN + DE N + E C EC + + + + L+LHA++Y ++ + ++TD+P W L Sbjct: 10 YTQNGLRKVRPYYNRRSAFVKGRWLGKLLIDVLVSEFKLRPRAYYLDQIRKGTYRLIRDGVPLVPDHLMTTIIKNHDVLETTTHKHEPPVKQWCSQEVEAEDLPGRIAGFNIVFEDESILVIDKPSGIPVHPTGQFYQNTITELL-KLHGVDALPC-YRLDKITSGLLILAKNSQSAGEIQKSIRSRDMIKIYLARVKGRFPHSELILDNENAAETTFEDTSKVTVEMTPIYSIDPKRQFPVGLSTSKDAITKFYPIRYFSHADETVVACKPITGRTHQIRIHLARLGHPIVNDSVY-----------CSHITKYPERL-------KFITQFPRWENQQDLDAEELKVRFQKFVDETKNNCRTMETFCPECHTVDLKDPVLSDLELWLHAWKYEEINGKFKFKTDLPKWAQL 401
BLAST of Pseudouridine synthase vs. Ensembl Yeast
Match: PUS5 (Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability [Source:SGD;Acc:S000004155]) HSP 1 Score: 46.595 bits (109), Expect = 2.863e-6 Identity = 53/197 (26.90%), Postives = 83/197 (42.13%), Query Frame = 2 Query: 500 LDEPIKIIHESDTVLVVCKPSSMP-----VHSVSKYHFN--------TVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLS-----GQIRDRQVLKYYLAVV--SGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHL-QYLGFPISND 1027 L + I II E+ +V KP +P + + H N I + ++ R +HR+D +G +L K + S K S G ++ + Y+A+V SG+FN+ I K G Y + GG+ TKF + N ++ + +TG+ HQIR H+ Q L PI ND Sbjct: 3 LKKQIPIIFENTHYFIVNKPPGIPSQPPDCRTWGRTHPNLDPTPLLERFKAIYYSHREVELCRTVHRLDHCVTGGMLIAKTKDGSVKFSRFLQKGGNNGYKLQRKYVAIVESSGRFNKPNNYEI-----------KYGPKYNFLISHGGR-EITKFKEVDEN------CIVLQLVTGKKHQIRNHVSQILNQPILND 181
BLAST of Pseudouridine synthase vs. Ensembl Nematostella
Match: EDO47303 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMP5]) HSP 1 Score: 242.662 bits (618), Expect = 2.693e-75 Identity = 147/422 (34.83%), Postives = 215/422 (50.95%), Query Frame = 2 Query: 251 FQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDV----SVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPS-----------------C-------------DECLSRFSCNEDVD--------------NFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 F G R V PY+ TF S+ K RWLN+ + ++F +F S S + + IE+ + +N ++ +L+ NDV+ +RVHRHE PV D+P++II +D ++V+ KPSS+PVH +Y NTV+ +L K H ++ L IHRIDR+TSGIL+F K + L Q+RDRQV K YL V G+F E P++C++ + ++ KVG+ V GK T F L N K S+V C P TGR HQIRVHLQ+LG+PI +DP+YN +WG +G+ GV ++I+ L + + V + ET T N I+ + + PS C DE + D D ++LHA Y+ DW+Y T +P+W Sbjct: 1 FSTGLRHVKPYYFTFTSHCKGRWLNRELLDIFREEFRSESISYYEKAIESGKITVNGEKVLPTTVLRGNDVLRNRVHRHEPPVTDQPLEIICNTDDIVVLNKPSSIPVHPCGRYRHNTVVFLLGKEHNLRNLYTIHRIDRLTSGILMFAKTLTRARMLEAQVRDRQVEKEYLCRVQGEFPSE---PVDCEQPIIVVSHKVGICRVSP---DGKSCRTVFTKLHSNGKS--SVVKCIPYTGRMHQIRVHLQWLGYPIIDDPIYNHPAWGTKRGRGGVTDDQALEVIKALAQSTTIIEGDDVGYTPRDREAETRPIPTHNSKNINTGMSLAQAHAPSGLTAEQSAHGLTPVPNKCRDDNANMETGAQHDEMSPQGEGERDADCSECRIWRRDPTPQELTMYLHALSYK--GPDWEYCTSVPSWA 412
BLAST of Pseudouridine synthase vs. Ensembl Nematostella
Match: EDO47554 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM79]) HSP 1 Score: 53.5286 bits (127), Expect = 8.476e-8 Identity = 56/194 (28.87%), Postives = 85/194 (43.81%), Query Frame = 2 Query: 518 IIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLR----VIHRIDRMT----------SGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCP---------KVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQ-YLGFPISND 1027 +I ++ ++ + KP +PVH +V +L + I+ + + HR+D+ SG+LL ++ + K++ + R V K YLAV G E E I G + P VG + + E G K A TKF L N+ SL+ +P+TG QIRVHL L PI D Sbjct: 25 VIFSNNDLIAINKPYGLPVHGGPGVVL-SVAELLEEFAAIKNYQNKPELAHRLDKYGTDYTIMLIDCSGVLLLTRNKTAAQKIAEMFQSRMVKKRYLAVSVGVPRYE-EGTISIPVGYGRVGPWERIIIRQDLVGKTHKEITEAGFKQAITKFKILDENQ-STCSLLEIEPITGHKQQIRVHLADALRCPILGD 215
BLAST of Pseudouridine synthase vs. Ensembl Medaka
Match: rpusd2 (RNA pseudouridine synthase domain containing 2 [Source:NCBI gene;Acc:101173104]) HSP 1 Score: 254.988 bits (650), Expect = 3.070e-78 Identity = 155/430 (36.05%), Postives = 231/430 (53.72%), Query Frame = 2 Query: 218 SDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKET-NLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKS----------------------IISDEEARNKY--FEPS-------------------CDEC-LSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWV 1372 S ++ + YYF G RKVHPY+ F++ K RW+ KS+ EVFE++F + + + + + + +N +L +LK ND + + VHRHE PV+ P++I+ + VLVV KP+S+PVH ++ NTV+ IL K +G+ +L +HR+DR+TSG+LLF + ETS KL +RDR++ K Y+ V G+F E + + C++ + ++ KVGL V+ GK T F L +N K S+V C PLTGRTHQIRVHLQ+LGFPI NDP+Y +WG ++GK GV KS E++++ L V HR E NP+ L T K +I+D + P+ C EC + R E +++LHA RY+ D++Y T +P W Sbjct: 123 SQEHFSETSYYFDGGLRKVHPYYFDFKTYCKGRWIGKSLLEVFESEFRAETVEYYQQAAKEGRIRLNEAPVEDLSVVLKNNDHMRNTVHRHEPPVVGTPLEILVDDGQVLVVDKPASIPVHPCGRFRHNTVIFILGKEYGVSELHTVHRLDRLTSGVLLFARTVETSKKLDKMVRDREIEKEYVCRVEGEFPEGE---LVCEEPILVVSFKVGLC---RVDPKGKECRTVFQRLSFNGK--TSVVRCSPLTGRTHQIRVHLQFLGFPILNDPIYGSSAWGPNRGKGGVVGKSDEEILQAL-----VEEHRSQE--NPDLLNDLTGGKEVAEKNFTDKCRQQVDPCGDETDVITDSTSVKDSINLPPTTANGSEKTADVPKISQDHLCSECKIVRPDPTE--KELIMYLHALRYK--GPDFEYFTRLPEWA 533
BLAST of Pseudouridine synthase vs. Ensembl Medaka
Match: rpusd1 (RNA pseudouridine synthase domain containing 1 [Source:NCBI gene;Acc:101166304]) HSP 1 Score: 61.6178 bits (148), Expect = 3.794e-10 Identity = 59/195 (30.26%), Postives = 84/195 (43.08%), Query Frame = 2 Query: 494 PVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQL---------RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE--EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYN 1039 P E + ++H S LV+ K + + S Y TV L H L R H++D TSG L + + + +DR V K YLA+V G EE Q I K + ++ E E K + TK L+Y + ++ VL +PLTGRTHQ+RVH +G I D Y+ Sbjct: 6 PASIENLHVLHHSKDFLVLDKHWDIRIDSKMWYEKLTVQAQLQ--HHFPDLADPSTYYGFRFCHQLDFSTSGALCVALNKAAAGRAYRCFKDRTVTKAYLALVRGTV-EETTQTIRFSIGKNSTEGKKHMMLIEGSEGCENPKPSETKLTVLEYGLYDGDPVTKVLLQPLTGRTHQLRVHCSAIGHSIVGDFTYS 197
BLAST of Pseudouridine synthase vs. Ensembl Medaka
Match: rpusd1 (RNA pseudouridine synthase domain containing 1 [Source:NCBI gene;Acc:101166304]) HSP 1 Score: 61.6178 bits (148), Expect = 3.794e-10 Identity = 59/195 (30.26%), Postives = 84/195 (43.08%), Query Frame = 2 Query: 494 PVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQL---------RVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVE--EGGKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYN 1039 P E + ++H S LV+ K + + S Y TV L H L R H++D TSG L + + + +DR V K YLA+V G EE Q I K + ++ E E K + TK L+Y + ++ VL +PLTGRTHQ+RVH +G I D Y+ Sbjct: 6 PASIENLHVLHHSKDFLVLDKHWDIRIDSKMWYEKLTVQAQLQ--HHFPDLADPSTYYGFRFCHQLDFSTSGALCVALNKAAAGRAYRCFKDRTVTKAYLALVRGTV-EETTQTIRFSIGKNSTEGKKHMMLIEGSEGCENPKPSETKLTVLEYGLYDGDPVTKVLLQPLTGRTHQLRVHCSAIGHSIVGDFTYS 197
BLAST of Pseudouridine synthase vs. Planmine SMEST
Match: SMESG000051935.1 (SMESG000051935.1) HSP 1 Score: 895.575 bits (2313), Expect = 0.000e+0 Identity = 446/452 (98.67%), Postives = 447/452 (98.89%), Query Frame = 2 Query: 104 MEDFXXXXXXXXXXXXXXLFRKEALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPIKIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEEKEQPIECKKSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSPTDKDTLINKLEFLTGSDCDIFD 1459 MEDFSSSKKHKMSKEEKKL RKEALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPI IIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVV GKFNEEKEQPIEC K LGILCPKVGLAY+KSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSPTDKDTLINKLEFLTGSDCDIFD Sbjct: 1 MEDFSSSKKHKMSKEEKKLLRKEALKFKTGENKKNKIISDQYQGDCVYYFQNGFRKVHPYFHTFQSNIKERWLNKSVKEVFENDFYSNSPLFVKSQIENKNLLINNKETNLDYILKPNDVITHRVHRHELPVLDEPINIIHESDTVLVVCKPSSMPVHSVSKYHFNTVMGILHKSHGIQQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVGGKFNEEKEQPIECNKPLGILCPKVGLAYLKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLYNCISWGKDKGKCGVYHKSKEQLIEDLMANHDVSVHRFYENGNPETLQTFTENKSIISDEEARNKYFEPSCDECLSRFSCNEDVDNFVLFLHAYRYRTVDTDWDYRTDIPNWVGLFALSPTDKDTLINKLEFLTGSDCDIFD 452
BLAST of Pseudouridine synthase vs. Planmine SMEST
Match: SMESG000021497.1 (SMESG000021497.1) HSP 1 Score: 60.4622 bits (145), Expect = 7.403e-10 Identity = 44/149 (29.53%), Postives = 69/149 (46.31%), Query Frame = 2 Query: 644 LRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFN-----EEKEQPIECKK---SLGILCPKVGLAYVKSVEEG--------GKIASTKFMFLKYN--EKQNLSLVLCKPLTGRTHQIRVHLQYLGFPISNDPLY 1036 R H++D TSG++ G + ++S R K YLA+V G N + +EC + +G Y + ++ + AST+ M L++ + + S VL PLTGRTHQ+RVH ++LG I D +Y Sbjct: 101 FRFCHQLDYSTSGVICIGYNKAGCGQVSKSFEKRTAKKQYLALVWGHLNLNNCNSKMTNGLECYRINTEIGTKQVTYSTGYSQYIQCTIDDPLCIKPQSASTEIMVLEHGLYDNKAASKVLLIPLTGRTHQLRVHCKHLGHNIIGDCMY 249
BLAST of Pseudouridine synthase vs. Planmine SMEST
Match: SMESG000060928.1 (SMESG000060928.1) HSP 1 Score: 58.9214 bits (141), Expect = 3.772e-9 Identity = 53/154 (34.42%), Postives = 78/154 (50.65%), Query Frame = 2 Query: 638 QQLRVIHRIDRMTSGILLFGKDYETSSKLSGQIRDRQVLKYYLAVVSGKFNEE--------KEQPIECK-------KSLGILCPKVGLAYVKSVEEGGKIASTKFMFLKYNEKQNLSLVLCKPLTGRTHQIRVHLQY-LGFPISNDPLYNCISW 1051 ++L ++HR+D+ T+G+LL ++ +++ L ++R + K YL + G +EE KE + + KS+ K G + KS E GKI ST F L N N+SLV C ++G HQIR HL Y L PI D Y SW Sbjct: 135 ERLHIVHRLDKDTTGVLLLAQNPDSAFLLKDAFKERHIRKNYLCLTHGIPHEEHGIINFNLKEATLGDQIVIRPDMKSVKKNIKKAG--FTKS--EPGKI-STAFNVLCSN--YNISLVQCAMISGVKHQIRAHLAYGLETPILGDHKY---SW 278 The following BLAST results are available for this feature:
BLAST of Pseudouridine synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Pseudouridine synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Pseudouridine synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Pseudouridine synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of Pseudouridine synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of Pseudouridine synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of Pseudouridine synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Pseudouridine synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Pseudouridine synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Pseudouridine synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Pseudouridine synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 4
BLAST of Pseudouridine synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Pseudouridine synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of Pseudouridine synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30027035 ID=SMED30027035|Name=Pseudouridine synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=1479bpback to top protein sequence of SMED30027035-orf-1 >SMED30027035-orf-1 ID=SMED30027035-orf-1|Name=SMED30027035-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=487bp MKLKVIFDLIFAPVKKISYLNIIDIITMKRLSKNMEDFSSSKKHKMSKEEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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