Cleavage stimulation factor subunit 1

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++ +++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YTGAG +GRQ+HR+ AVFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYT 1056
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++ +++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YT
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT 345          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYT 1056
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++ +++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YT
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT 345          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLA 441
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLA
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLA 142          

Query:  256 MDLDVETESSTMAPEAALYE-TCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            + L      S   PE   Y   C +  H  A  +  F+  G+ +A+ S D  I I           G  D   +             +TLY H  E+S V +  D +   L S S D T+KL+D  +    K  K    ++ V    F+   + ++ G++ +T++I++V T +C  +      H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+LT+  D+ +KLW+ S GRCL  YTG
Sbjct:   13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW----------GAYDGKYE-------------KTLYGHNLEISDVAWSSDSSR--LVSASDDKTLKLWDVRSGKCLKTLKG--HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL---SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVD-DDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250          

Query:  565 DPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRI---YDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLC-CWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFW-YKR 1302
            D   Q+  S S + + ++ +  N ++K       EA  V ++KF  +G+ L   +  + + I   YD    +          HN  I+ V WS +SS   S S D + K+WD  S +C+ T  K H  + +    F+  S  +++   D  VK+WE+ TG+CL   +        +H     FN +   ++    D   LC  WD+      + L  + N  V     SP     L+ + DN  + W Y R
Sbjct:    8 DAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEA--VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG------HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNY-VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVH-----FNCSGSLIVSGSYD--GLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGP-SNRLLKLMQLGLSISDDEADRCNLKEDSIT---PGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR+ +YRLII QL +DG+Q  A+++  T+  S  + P S++L +L+ +     +D   +   K   +      +G+DL+ + +   ++ E + YET Y+T HKA CRAAAFN+ G LVATGS D SIKI+DVER+LA+         + N+      HPVIRTLYDH  +V+ V FHP  +  IL SGS D T+KLFDFS  +VKKA K++ E  PVR +  H  G+ LLV T H T+R+Y++ T Q + SA P+DQH  ++  V +S N+ ++ + S DG  KIWDGVS RC+ TF++AH+G  I S +F++N KY+LTSG DSIVKLWELST RCLI YTGAG TG Q   + A FNH EDYV+FPDE + S+C WD+R +DR+RLL+L H  A R FVHSP+  AF++ SDD+RARFWY++P ++
Sbjct:    6 KDREYMYRLIIGQLFYDGHQQIAVNLANTLGCSAPAPPPSDKLFRLVTIAKQFVEDPDYKAEEKSSPMQFEPVSSGLDLEYDADVQPVSSEPSEYETIYLTVHKAPCRAAAFNSDGSLVATGSADCSIKIMDVERILARE----KEHREMNENGPDAHHPVIRTLYDHVDDVNTVIFHPRDS--ILISGSNDKTVKLFDFSKTAVKKAMKTLSEVYPVRALSCHPGGEFLLVATDHPTVRLYNIETAQAYASANPDDQHTESVTDVHYSENARLYVTASKDGHVKIWDGVSNRCVETFKRAHDGSSICSAKFTKNGKYILTSGMDSIVKLWELSTNRCLIVYTGAGATGAQDFATNASFNHNEDYVLFPDEKSGSMCSWDARNSDRKRLLALGHTSACRTFVHSPSMPAFMTGSDDHRARFWYRKPATN 428          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGP-SNRLLKLMQLGLSISDDEADRCNLKEDSIT---PGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR+ +YRLII QL +DG+Q  A+++  T+  S  + P S++L +L+ +     +D   +   K   +      +G+DL+ + +   ++ E + YET Y+T HKA CRAAAFN+ G LVATGS D SIKI+DVER+LA+         + N+      HPVIRTLYDH  +V+ V FHP  +  IL SGS D T+KLFDFS  +VKKA K++ E  PVR +  H  G+ LLV T H T+R+Y++ T Q + SA P+DQH  ++  V +S N+ ++ + S DG  KIWDGVS RC+ TF++AH+G  I S +F++N KY+LTSG DSIVKLWELST RCLI YTGAG TG Q   + A FNH EDYV+FPDE + S+C WD+R +DR+RLL+L H  A R FVHSP+  AF++ SDD+RARFWY++P ++
Sbjct:    6 KDREYMYRLIIGQLFYDGHQQIAVNLANTLGCSAPAPPPSDKLFRLVTIAKQFVEDPDYKAEEKSSPMQFEPVSSGLDLEYDADVQPVSSEPSEYETIYLTVHKAPCRAAAFNSDGSLVATGSADCSIKIMDVERILARE----KEHREMNENGPDAHHPVIRTLYDHVDDVNTVIFHPRDS--ILISGSNDKTVKLFDFSKTAVKKAMKTLSEVYPVRALSCHPGGEFLLVATDHPTVRLYNIETAQAYASANPDDQHTESVTDVHYSENARLYVTASKDGHVKIWDGVSNRCVETFKRAHDGSSICSAKFTKNGKYILTSGMDSIVKLWELSTNRCLIVYTGAGATGAQDFATNASFNHNEDYVLFPDEKSGSMCSWDARNSDRKRLLALGHTSACRTFVHSPSMPAFMTGSDDHRARFWYRKPATN 428          

Query:  319 CYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            C +  H  +  +A F+  G+ + T S D ++KI +++ M+ +                       RTL  H+  V+ + +  D   + + S S D T+K+F+     + K  K     + V    F+     ++ G++ +++RI+DV T  C +  +P   H+  ++ V+++ + S+ AS S DG  +IWD  + +CI T     E  P++ V+FS N KY+L S  DS +KLW+ S G+ L +YTG
Sbjct:   81 CTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICE-----------------------RTLTGHKLGVNDIAWSSDS--RCVVSASDDKTLKIFEIVTSRMTKTLKG--HNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMC-IKTLPA--HSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVD-DENPPVAFVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTG 296          

Query:  319 CYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            C +  H  +  +A F+  G+ + T S D ++KI +++ M+ +                       RTL  H+  V+ + +  D   + + S S D T+K+F+     + K  K     + V    F+     ++ G++ +++RI+DV T  C +  +P   H+  ++ V+++ + S+ AS S DG  +IWD  + +CI T     E  P++ V+FS N KY+L S  DS +KLW+ S G+ L +YTG
Sbjct:   81 CTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICE-----------------------RTLTGHKLGVNDIAWSSDS--RCVVSASDDKTLKIFEIVTSRMTKTLKG--HNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMC-IKTLPA--HSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVD-DENPPVAFVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTG 296          

Query:  331 AHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHT---EDYVMFPDEDTKSLCCWDSRKADRQRLLSLN-HNGAVRCFVHSPTTAAFLSCS--DDNRARFW 1293
            AHK +     F+  G+ + +GS D SIKI  ++ +  K                        TL  H+  ++  +F    + +++ S S D  +K+FD S+    K  K     + V    F+ SG  +  G++ +T+RI+         S +P   H   ++ V ++ + +  AS S DG  +IWD  +  C+ T     E  PI+ V+FS N KY+L S  ++ +KLW+    R L EY     TG +  + C   N +     +++   ED K +  W+ +   R+ L +L+ HN AV C    P      S +   D R + W
Sbjct:  105 AHKKSISGIKFSPDGRYMGSGSADCSIKIWRMDFVYEK------------------------TLMGHRLGIN--EFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVKTLKG--HTNYVFCCCFNPSGTLIASGSFDETIRIWCARNGNTIFS-IP--GHEDPVSSVCFNRDGAYLASGSYDGIVRIWDSTTGTCVKTLID-EEHPPITHVKFSPNGKYILASNLNNTLKLWDYQKLRVLKEY-----TGHENSKYCVAANFSVTGGKWIVSGSEDHK-VYIWNLQT--REILQTLDGHNTAVMCTDCHPGQNIIASAALEPDMRIKIW 391          

Query:   34 MYKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKR 1302
            + K+R++LYRL+ISQL++DG +  A+ +   V  +    PS RLL +M  G+    D+ D+ N   D + PG  +DL+ E E+S +APE   YET YVT+HK ACRA AF+  G LVATGS D+SIKILDVERMLAKS  P D      QQ     HPVIRTLYDH  EVS ++FHP  +  ILAS S+D T+KLFD + PSVKKA K   +  PV  + FH +GD + +GT H  LR+YDV TTQCFVSA+P  QH   +  V +SP   ++A+ S DG  KIWDG+S RCINT  +AH G  I S++F+RN KYLL+SG DS+V LWEL T R +  YTGAGTTG+Q H++ AVFNHTEDYV+FPDE T SLC W+SR   R  L SL HNG VR   HSP   AFL+CSDD RARFWY+R
Sbjct:   11 LVKNREILYRLMISQLMYDGLEKFAMELSMLVK-ADQCAPSERLLHVMIAGMQTLSDK-DKTN--SDDVLPG--IDLEFEPEASALAPEPHSYETAYVTSHKQACRAGAFSCDGSLVATGSVDASIKILDVERMLAKSA-PEDIEPGREQQG----HPVIRTLYDHTDEVSYLEFHPKEH--ILASASRDGTVKLFDIAKPSVKKAHKVFTDCEPVLCLSFHPTGDYVAIGTEHNVLRVYDVATTQCFVSAIPSQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAEAHGGAAICSLEFTRNGKYLLSSGMDSLVYLWELCTSRPIQTYTGAGTTGKQEHQTEAVFNHTEDYVLFPDEATTSLCSWNSRNGCRLTLNSLGHNGPVRYITHSPNGPAFLTCSDDFRARFWYRR 420          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSC--AVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCS--DDNRARFW 1293
            +  H  A  A  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D  L  L SGS D T+K+++ S     K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  Y     TG +  + C  A F+ T    +    +   +  W+ +  +  + L   H   V C    PT     S +  +D   + W
Sbjct:   68 LAGHTKAVSAVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSRL--LVSGSDDKTLKVWELSTGKSLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKC-LKTLPA--HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-----TGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQ-GHTDTVLCTACHPTENIIASAALENDKTIKLW 357          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSC--AVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCS--DDNRARFW 1293
            +  H  A  A  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D  L  L SGS D T+K+++ S     K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  Y     TG +  + C  A F+ T    +    +   +  W+ +  +  + L   H   V C    PT     S +  +D   + W
Sbjct:   68 LAGHTKAVSAVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSRL--LVSGSDDKTLKVWELSTGKSLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKC-LKTLPA--HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-----TGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQ-GHTDTVLCTACHPTENIIASAALENDKTIKLW 357          

Query:  499 THPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEY-TGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCC--WDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWY 1296
            T  ++  L  H  +++ V +HP+ +  I  +GS D  I+++       +   +      PV  +  H +GD LL  +  K     D+ T +     +  D     +    + P+  +F + +VD   KIWD      +  F   H G PIS++ FS N  YL T+  D+ VKLW+L   R L  + T     G ++   C  F+ +  Y+     D +   C  W       Q L   N + A+   V     A +L+ +  +R    Y
Sbjct:  254 TEQMVAILKGHTKKITKVIYHPNEDTVI--TGSPDMNIRIWHVPTSQTQLLLRC--HEGPVTGLSLHPTGDYLLSTSSDKHWAFSDIRTGRLLTKVI--DTAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSNVANF-PGHTG-PISAISFSENGYYLATAADDACVKLWDL---RKLKNFKTIQLDDGYEVKDLC--FDQSGTYLAIAGSDVRVYLCKQW-------QELKVFNDHTALATGVRFGKHAQYLASTSMDRTLKLY 502          

Query:  298 EAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHN-------------------GAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCL 1044
            E   YE   +  H  + +  AF+A G+L+A+ S D SIK+ D ++                      ++  I+T++ H   VS V F P  +   + S S+D TIK+++ +     K +    E   VR ++ H  G      +  +T+R++  N+  C V  + + +H                    GA N           AS S D + +IWD     C+ T    H+ + +  + F    KYL+++  D  +++W+L   RC+
Sbjct:  138 ETGEYERS-LKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQ----------------------SYECIKTMHGHDHNVSSVAFVPAGDY--VLSASRDRTIKMWEVATGYCVKTYTGHREW--VRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVE-LRDHEHTVECIAWAPEAAASAINEAAGADNKKG-HHQGPFLASGSRDKTIRIWDVSVGLCLLTLS-GHDNW-VRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCM 374          

Query:  313 ETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASP----VRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRC-INTFEKAHEGFPISSVQF-----------SRNSK------YLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSR 1173
            E   +T H+A+     F+    L+ + SED++I+I D E                       T    R+L  H   V  V F  D   ++LAS S D +IKL+DF     +++++ I         V ++ F  +GD +L  +  +T+++++V T  C  +      H   + MV      S+FA+CS D + ++W   S  C +   +  H    I+               + N K      +L +  +D  +++W++S G CL+  +G     R L      F+    Y++   +D K++  WD R
Sbjct:  100 EKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFE-----------------------TGEYERSLKGHTDSVQDVAF--DAQGKLLASCSADLSIKLWDF-----QQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTG---HREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGL-----AFHPGGKYLVSASDD-KTIRVWDLR 369          

Query:  505 PVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWD-GVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            P   +L  H+A ++ V FHP     ++ S S+D TI+++DF                                G Y ++L+                  H  ++  V +     + ASCS D S K+WD   S  CI T    H+   +SSV F     Y+L++ +D  +K+WE++TG C+  YTG
Sbjct:   99 PEKFSLTGHRASITRVIFHP--IFALMVSASEDATIRIWDFET------------------------------GEYERSLK-----------------GHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMH-GHD-HNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTG 233          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY   A  +++ V P     PS +L++L ++G+   D        + D++ PG G+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  P++ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK + EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFVS  P DQH   I  V ++P+++ + +CS DGS K+WDGVS RC+ TF+KAHEG  + S  FS+NSKY+L++GKDS+ KLWE+STGR L++YTGAG +GRQ HR+  VFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQHLYKLIISQLLYDGYTIIANSLISEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPLEVMMNETAQQNMENHPVIRTLYDHVDEVTCLSFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKHVQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFVSCNPLDQHTDTICGVCYNPSANSYVTCSKDGSIKLWDGVSNRCVTTFDKAHEGAEVCSAVFSKNSKYILSTGKDSVAKLWEISTGRTLVKYTGAGLSGRQTHRTQGVFNHTEDYVLLPDERTISLCCWDSRTAERKNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRTTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY   A  +++ V P     PS +L++L ++G+   D        + D++ PG G+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  P++ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK + EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFVS  P DQH   I  V ++P+++ + +CS DGS K+WDGVS RC+ TF+KAHEG  + S  FS+NSKY+L++GKDS+ KLWE+STGR L++YTGAG +GRQ HR+  VFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQHLYKLIISQLLYDGYTIIANSLISEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPLEVMMNETAQQNMENHPVIRTLYDHVDEVTCLSFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKHVQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFVSCNPLDQHTDTICGVCYNPSANSYVTCSKDGSIKLWDGVSNRCVTTFDKAHEGAEVCSAVFSKNSKYILSTGKDSVAKLWEISTGRTLVKYTGAGLSGRQTHRTQGVFNHTEDYVLLPDERTISLCCWDSRTAERKNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRTTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQH 804
            KDR  LY+LIISQLL+DGY   A  +++ V P     PS +L++L ++G+   D        + D++ PG G+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  P++ M  E  QQ ME HPVIRTLYDH  EV+C+ FH  P  QILASGS+DYT+KLFD+S PS K+AFK + EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFVS  P DQH
Sbjct:    9 KDRQHLYKLIISQLLYDGYTIIANSLISEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPLEVMMNETAQQNMENHPVIRTLYDHVDEVTCLSFH--PTEQILASGSRDYTLKLFDYSKPSAKRAFKHVQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFVSCNPLDQH 261          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFV 780
            KDR  LY+LIISQLL+DGY   A  +++ V P     PS +L++L ++G+   D        + D++ PG G+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  P++ M  E  QQ ME HPVIRTLYDH  EV+C+ FH  P  QILASGS+DYT+KLFD+S PS K+AFK + EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFV
Sbjct:    9 KDRQHLYKLIISQLLYDGYTIIANSLISEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPLEVMMNETAQQNMENHPVIRTLYDHVDEVTCLSFH--PTEQILASGSRDYTLKLFDYSKPSAKRAFKHVQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFV 253          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLY 525
            KDR  LY+LIISQLL+DGY   A  +++ V P     PS +L++L ++G+   D        + D++ PG G+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  P++ M  E  QQ ME HPVIRTLY
Sbjct:    9 KDRQHLYKLIISQLLYDGYTIIANSLISEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPLEVMMNETAQQNMENHPVIRTLY 170          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQ+L+DGY   A  +++ +   +   PS +LL L+++G+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGSKDYT+KLFD+S PS K+AFK I EA  +R+I FH SGD ++VGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++P+++ + +CS DGS K+WDGVS RCI T+EKAH+G  + S  FS+NSKY+L+SGKDS+ +LWE+STGR L++YTGAG +GRQ+HR+ AVFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQMLYDGYINIANGLISELKIHSVCAPSEQLLHLIKVGMENDDSAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSKDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFIIVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNPSANTYVTCSKDGSIKLWDGVSNRCITTYEKAHDGAEVCSAIFSKNSKYILSSGKDSVARLWEISTGRMLVKYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:  262 LDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYT 1056
            + + +  S + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YT
Sbjct:   20 ISIHSPFSLVKPNYTLKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLPA--HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 251          

Query:  229 EDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYT 1056
            E S T  T    + +++ + + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YT
Sbjct:   11 EASKTQSTPSSSNNQSKPAPVKPNYTLKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253          

Query:  229 EDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYT 1056
            E S T  T    + +++ + + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YT
Sbjct:   11 EASKTQSTPSSSNNQSKPAPVKPNYTLKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253          

Query:  229 EDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYT 1056
            E S T  T    + +++ + + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YT
Sbjct:   11 EASKTQSTPSSSNNQSKPAPVKPNYTLKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++P+++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YTGAG +GRQ+HR+ AVFNHTEDY++ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNPSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYILLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPID 462
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIE 149          

Query:  277 ESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFP-ISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            E     P  AL  T  +  H AA  +  F+  G+ +A+ + D+ I I           G  D   +             +TLY H  E+S V +  D +   L S S D T+K++D  +    K  K    +  V    F+   + ++ G++ ++++I++V T +C  +      H+  I+ V ++ N S+  S S DG  +IWD  S +C+ T   A EG P +S V+FS N KY+LT+  D+ +KLW+ S GRCL  YTG
Sbjct:   21 EEEPQKPNYALRLT--LAGHSAAISSVKFSPNGEWLASSAADALIIIW----------GAYDGNCK-------------KTLYGHSLEISDVAWSSDSSR--LVSASDDKTLKVWDMRSGKCLKTLKG--HSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTL---SAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTL--ADEGNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 248          

Query:  511 IRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFE-KAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            ++TL  H   V C DF+P  NL  + SGS D ++K+++       K   +   + P+  + F+ +G  ++ G+Y    RI+D  + QC  +    D+ N  ++ V +SPN     + ++D + K+WD    RC+ T+    +E + + +       K++++  +D++V +W L T   +    G
Sbjct:  116 LKTLKGHSDFVFCCDFNPPSNL--IVSGSFDESVKIWEVKTGKCLKTLSA--HSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLA--DEGNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQG 293          

Query:  271 ETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            +++ + + P  AL  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:   25 QSKPTPVKPNYALKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254          

Query:  514 RTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINT---FEKAHEGF------------PISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T   F  +HE              P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:   12 KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIVFVTSHEKRSPLRTPCDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 201          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEAS-PVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQC------FVSA--------VPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFE-KAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            ++ HK      A+++   L+ + S+D ++KI DV                        +   ++TL  H   V C +F+P  NL  + SGS D +++++D       K  K++P  S PV  + F+  G  ++  +Y    RI+D  + QC      FV++         P D  N  ++ V +SPN     + ++D + K+WD    +C+ T+    +E + I +       K++++  +D++V +W L T   + +  G
Sbjct:   14 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS-----------------------SGKCLKTLKGHSNYVFCCNFNPQSNL--IVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIVFVTSHEKRSPLRTPCDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG 246          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++P+++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YTGAG +GRQ+HR+ AVFNHTEDY++ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNPSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYILLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++P+++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YTGAG +GRQ+HR+ AVFNHTEDY++ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNPSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYILLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++ +++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YTGAG +GRQ+HR+ AVFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  + P +   PS +LL L++LG+   D        + D++ PGTG+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD +LVGT H TLR+YD+NT QCFVS  P+DQH  AI  V ++ +++M+ + S DG  K+WDGVS RCI TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L+ YTGAG +GRQ+HR+ AVFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHADAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRIAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431          

Query:   55 LYRLIISQLLFDGY-QTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDS--------ITPGTG-MDLDVE--TESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFV-SAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFW 1293
            L  LI++ L      Q A+     T+ P     P NRLL+L+  GL+  ++   R                TP T  +D  V     SS   P+   +E+  ++ HK+  R A F+  G   ATG  D+SIK+ +V ++     G              +  P+IRT YDH   ++ +DFHP     IL S +KD  IK FDFS  + K+AFK   +   VR+I FH SG+ LL GT H    +YDVNT QCF+ S  P+   +GAIN V +S   S++ + S DG+ +++DGVS +C+ +   AH    ++S  F+++ +++L+SGKDS VKLWE+ +GR + EY GA    R   RS A+FN TE++V+  DE +  +  WD+R AD+      NHNGA R   HSP  + F++C  D   RFW
Sbjct:   20 LNALIVAHLRHHNLSQVASAVASATMTPLNIEVPPNRLLELVAKGLAAENNGTLRGVSSSVLLPSSYGSITTPRTASIDFSVNHAKGSSKTIPK---HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVPKVKQMISG------------DTQARPLIRTFYDHAEPINDLDFHPRST--ILISSAKDNCIKFFDFSKTTAKRAFKVFQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFLPSNFPDSGVSGAINQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGNAHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGA---KRVKLRSQAIFNDTEEFVISIDEASNEVVTWDARTADKVAKWPSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 425          

Query:   37 YKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKE-DSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            +K+RDLLYRLIISQL +DG+QT A++++  V+PS + GPSNRL +L++LGLS S+DE ++  + E +SI PGTG+DL+VE+ESSTMAPEAALYETCYVTAHKAACRAA+FN+TGQLVATGS DSSIKILDVERMLAKS  P D++GQE  QQQMETHPVIRTLYDH AEV+CVDFHPDP LQIL SGSKDYTIKLFDFSNPSVKKA ++IPEASP+RT+ FH SG+ LLVGT HKTLR+YDV T +C+VSAVPEDQH  A+NMV WSPN + F +  +DGSFKIWDGVSCRC+NTFE AH+G P+ SV FSRN KY+L+SGKDS VKLWEL+TGRCLI YTGAGT G Q HRS AVFNHTEDYV+FPDE TKSLCCWDSR ADRQRLLSLNHNG +RCFVHSPTTAAF+SCSDDNRARFWYKRPISD
Sbjct:    3 FKERDLLYRLIISQLFYDGFQTMAVNLVNLVSPSAACGPSNRLFRLVKLGLSASEDEHEKSGVIEGESIAPGTGIDLEVESESSTMAPEAALYETCYVTAHKAACRAASFNSTGQLVATGSHDSSIKILDVERMLAKSVSPTDHLGQETPQQQMETHPVIRTLYDHTAEVTCVDFHPDPTLQILVSGSKDYTIKLFDFSNPSVKKAQRNIPEASPIRTLHFHPSGNFLLVGTQHKTLRLYDVQTCRCYVSAVPEDQHLSAVNMVRWSPNGTAFVTAGMDGSFKIWDGVSCRCVNTFEAAHDGAPVCSVVFSRNGKYILSSGKDSAVKLWELATGRCLITYTGAGTVGHQTHRSMAVFNHTEDYVLFPDEATKSLCCWDSRNADRQRLLSLNHNGPIRCFVHSPTTAAFMSCSDDNRARFWYKRPISD 429          

Query:   37 YKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKE-DSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            +K+RDLLYRLIISQL +DG+QT A++++  V+PST+ GPSNRL +L++LGLS+S+DE ++  + E +SI PGTG+DL+VE+ESSTMAPE+ALYETCYVTAHKAACRAA+FN+TGQLVATGS DSSIKILDVERMLAKS  P D++GQE  QQQMETHPVIRTLYDH AEV+CVDFHPDP LQIL SGSKDYTIKLFDFSNPSVKKA ++IPEASP+RT+ FH SG+ LLVGT HKTLR+YDV T +C+VSAVPEDQH  A+NMV WSPN + F +  +DGSFKIWDGVSCRC+NTFE AH+G P+ SV FSRN KY+L+SGKDS VKLWEL+TGRCLI YTGAGT G Q HRS AVFNHTEDYV+FPDE TKSLCCWDSR ADRQRLL+LNHNG +RCFVHSPTTAAF+SCSDDNRARFWYKRPISD
Sbjct:    3 FKERDLLYRLIISQLFYDGFQTMAVNLVNLVSPSTACGPSNRLFRLVKLGLSVSEDEHEKSGVIEGESIAPGTGIDLEVESESSTMAPESALYETCYVTAHKAACRAASFNSTGQLVATGSHDSSIKILDVERMLAKSVSPTDHLGQETPQQQMETHPVIRTLYDHTAEVTCVDFHPDPTLQILVSGSKDYTIKLFDFSNPSVKKAQRNIPEASPIRTLHFHPSGNFLLVGTQHKTLRLYDVQTCRCYVSAVPEDQHLSAVNMVRWSPNGTAFVTAGMDGSFKIWDGVSCRCVNTFEAAHDGAPVCSVVFSRNGKYILSSGKDSAVKLWELATGRCLIIYTGAGTVGHQTHRSMAVFNHTEDYVLFPDEATKSLCCWDSRNADRQRLLALNHNGPIRCFVHSPTTAAFMSCSDDNRARFWYKRPISD 429          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADR-CNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            ++RDLLYRLIISQL  DGYQT AI++M  VNPS S GPS RLLKL++LGLSI+DDE DR   L+ D+I PGTG+DL++E+ESSTMAPEAALYETCYVTAHKAACR AAFN TGQLVATGS DSSIKILDVERMLAKS    D+  QE  QQQME HPVIRTLYDH AEV+CVDFHPD + QIL SGSKDYTIK FDFSNPSVKKA +SIPEASP++T+ FH SG+ LLVGT HKTLRIY+VNT QC+VSAVPEDQHNGA+ M  W+PN++ F + SVDGSFKIWD VS RC++TFE AH+G P+ S  FSRNSKY+LTSGKDS+VKLWELST RCLI YTGAGT G Q HRS AVFNHTEDYV+FPDE TKSLCCWDSR ADRQRLL L+HNG +RCFVHSPTTAAFLSCSDDNRARFWYKRPISD
Sbjct:    4 RERDLLYRLIISQLFHDGYQTMAINLMNLVNPSMSCGPSARLLKLVKLGLSIADDEQDRPVTLEGDNIAPGTGIDLEIESESSTMAPEAALYETCYVTAHKAACRTAAFNTTGQLVATGSHDSSIKILDVERMLAKSVSGADHTNQETPQQQMEAHPVIRTLYDHTAEVTCVDFHPDASQQILVSGSKDYTIKFFDFSNPSVKKAQRSIPEASPIKTLNFHPSGNYLLVGTQHKTLRIYNVNTCQCYVSAVPEDQHNGAVTMARWAPNANYFVTSSVDGSFKIWDAVSGRCVSTFESAHDGAPVCSAVFSRNSKYVLTSGKDSVVKLWELSTSRCLISYTGAGTVGLQTHRSNAVFNHTEDYVLFPDEATKSLCCWDSRNADRQRLLPLSHNGPIRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 429          

Query:   37 YKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADR-CNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            +K+RDLLYRLIISQL +DGYQT A+++M  V+PS + GPSNRLLKL++ GLS+SDDE DR   L+ DSI PGTG+DL++E+ESSTMAPEAALYETCYVTAHKAACRAAAFN+TGQLVATGS DSSIKILDVERMLAKS    D+  QE  QQQMETHPVIRTLYDH AEV+CVDFHPDP+LQIL SGSKDYTIK FDFSNPSVKKA +SIPEASP++T+ FH SG+ LLVGT HKTLR+Y+VNT QC+VSAVPEDQHNGA+ M  W+PN++ F + SVDGSFK+WDGVS RC++TFE AH+G P+ S  FSRNSKY+LTSGKDSIVKLWELST RCLI YTGAGT G Q HRS A FNHTEDYV+FPDE TKSLCCWDSR ADRQRLLSLNHNG +RCFVHSPTTAAFLSCSDDNRARFWYKRPISD
Sbjct:    3 FKERDLLYRLIISQLFYDGYQTLAMNLMNLVSPSNACGPSNRLLKLVKTGLSVSDDEQDRPAFLEGDSIAPGTGIDLEIESESSTMAPEAALYETCYVTAHKAACRAAAFNSTGQLVATGSHDSSIKILDVERMLAKSVTGADHANQETPQQQMETHPVIRTLYDHTAEVTCVDFHPDPSLQILVSGSKDYTIKFFDFSNPSVKKAQRSIPEASPIKTLHFHPSGNYLLVGTQHKTLRLYNVNTCQCYVSAVPEDQHNGAVTMARWAPNANYFVTSSVDGSFKLWDGVSGRCVSTFESAHDGAPVCSAVFSRNSKYVLTSGKDSIVKLWELSTSRCLISYTGAGTVGLQTHRSMAAFNHTEDYVLFPDEATKSLCCWDSRNADRQRLLSLNHNGPIRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 429          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADR-CNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            ++RD+LYRLIISQL  DGYQ  AI++M  V PS S GPS RLLKL++LGLSI+DDE DR   L+ D+I PGTG+DL++E+ESSTMAPEAALYETCYVTAHKAACRAAAFN+TGQL+ATGS DSSIKILDVERMLAK     ++  QE  QQQME HPVIRTLYDH AEV+CVDFHPD + QIL SGSKDYTIK FDFSNPSVKKA +SIPEASP++T+ FH SG+ LLVGT+HKTLRIY VNT QCFVSAVPEDQHNGA+ M  W+PN++ F + SVDGSFKIWDGVS RC++TFE AH+G P+ S  FSRNSKY+LTSGKDS+VKLWELST RCLI YTGAGT G   HRS AVFNHTEDYV+FPDE TKSLCCWDSR ADRQRLL L+HNG +RCFVHSPTTAAFLSCSDDNRARFWYKRPISD
Sbjct:    4 RERDVLYRLIISQLFHDGYQAIAINLMNEVTPSVSCGPSARLLKLVKLGLSIADDEQDRSVALEGDNIAPGTGIDLEIESESSTMAPEAALYETCYVTAHKAACRAAAFNSTGQLIATGSHDSSIKILDVERMLAKGNSGPEHSAQETPQQQMEAHPVIRTLYDHTAEVTCVDFHPDASQQILVSGSKDYTIKFFDFSNPSVKKAQRSIPEASPIKTLHFHPSGNYLLVGTHHKTLRIYSVNTCQCFVSAVPEDQHNGAVTMARWAPNANYFVTSSVDGSFKIWDGVSGRCVSTFEAAHDGLPVCSAVFSRNSKYVLTSGKDSVVKLWELSTSRCLISYTGAGTLGLHTHRSNAVFNHTEDYVLFPDEVTKSLCCWDSRNADRQRLLPLSHNGPIRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 429          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY   A  ++  V P     PS +L++L ++G+   D        + D++ PG G+DL+ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  P++ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFVS  P DQH   I+ V ++P ++ + +CS DGS K+WDGVS RC+ TFEKAH+G  + S  FS+NSKY+L+SGKDS+ KLWE+STGR L++YTGAG +GRQ HR+  VFNHTEDY++ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQHLYKLIISQLLYDGYTNIANSLINEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPLEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKHIQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFVSWNPLDQHTDTISGVNYNPTANSYVTCSKDGSIKLWDGVSNRCVTTFEKAHDGAEVCSAVFSKNSKYILSSGKDSVAKLWEISTGRTLVKYTGAGLSGRQTHRTQGVFNHTEDYILLPDERTVSLCCWDSRTAERKNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRTTTD 431          

Query:  226 KEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            K DS T  T       T+ + + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             ++L  H+  +S V + PD NL  L S S D T+K++D  +    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  ++WD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:    7 KPDSATNKTHSSSAPATKPAPVKPNYTLKFT--LAGHTKAISSVKFSPNGEWLASSSADKLIKIW----------GSFDGKFE-------------KSLSGHKLGISDVAWSPDSNL--LVSASDDKTLKIWDMGSGKCLKTLKG--HSNYVFCCNFNPQSNLVVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRMWDSTSGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 251          

Query:  226 KEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            K DS T  T       T+ + + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             ++L  H+  +S V + PD NL  L S S D T+K++D  +    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  ++WD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:    7 KPDSATNKTHSSSAPATKPAPVKPNYTLKFT--LAGHTKAISSVKFSPNGEWLASSSADKLIKIW----------GSFDGKFE-------------KSLSGHKLGISDVAWSPDSNL--LVSASDDKTLKIWDMGSGKCLKTLKG--HSNYVFCCNFNPQSNLVVSGSFDESVRIWDVKTGKC-LKTLPA--HSDPVSAVHFNRDGSLIVSSSYDGLCRMWDSTSGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 251          

Query:  226 KEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            K DS T  T       T+ + + P   L  T  +  H  A  +  F+  G+ +A+ S D  IKI           G  D   +             ++L  H+  +S V + PD NL  L S S D T+K++D  +    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  ++WD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:    7 KPDSATNKTHSSSAPATKPAPVKPNYTLKFT--LAGHTKAISSVKFSPNGEWLASSSADKLIKIW----------GSFDGKFE-------------KSLSGHKLGISDVAWSPDSNL--LVSASDDKTLKIWDMGSGKCLKTLKG--HSNYVFCCNFNPQSNLVVSGSFDESVRIWDVKTGKC-LKTLPA--HSDPVSAVHFNRDGSLIVSSSYDGLCRMWDSTSGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 251          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            +  H  A  +  F+ +G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D S+    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:   41 LAGHTKAVSSVKFSPSGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXX--XXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            +DR+ LYRLIISQLL+DG+   A  ++  VN   +  PS RLL L ++G    D    R   + D + PGTG+DL+ + +  T +PEA  YETCYVT+HK  CR+A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+         QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DY++KLFDFS PSVK+A+KS+ EA  +R + FH +GD LLVGT H TLR+YDV T +C+VS  P DQH  A+  V ++P ++ + SCS DG+ K+WDGVS RC+ T+++AH G P+ SV FSRN+KY+L+SGKDS+V+LWELS GR L+ YTGAG +G+Q HR+ AVFNHTEDYV+FPDE T SLCCWDSR  +R+ LLSL HN AVRC VHSPT+A F++CSDD RARFWY+R  ++
Sbjct:   11 RDREELYRLIISQLLYDGHAAIAATLIGAVNLGPAVPPSERLLHLARIGKEQEDTNPSRPVGRSDMVAPGTGVDLEFDADVQTSSPEACEYETCYVTSHKGPCRSATYSRDGQLIATGSADASIKILDTERMLAKSATPIETQVMMNETAQQNMENHPVIRTLYDHTDEVTCLAFHPTE--QILASGSRDYSLKLFDFSKPSVKRAYKSLQEAEVLRCLAFHPAGDFLLVGTRHPTLRMYDVTTCECYVSPNPADQHTDAVTGVAYNPTANSYVSCSRDGTIKLWDGVSSRCVATYDRAHGGAPVCSVVFSRNAKYVLSSGKDSMVRLWELSAGRALLTYTGAGLSGKQTHRTQAVFNHTEDYVLFPDEWTVSLCCWDSRTTERKNLLSLGHNNAVRCLVHSPTSAGFMTCSDDYRARFWYRRAATE 435          

Query:  313 ETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWE 1023
            E+    AH A  R+ +F+A GQ + T S+D SIK+  V R                          + +L  H   V    F PD  L  + SGS D T++++D ++      F        V  + FH SG C+       T++++D+   +          H  A+N +++ P  +   + S D + K+ D V  R   T    H+G P ++V FSR   +  + G D  V +W+
Sbjct:   94 ESTVFKAHTATVRSVSFSADGQSLVTASDDKSIKVWTVHRQ-----------------------KFLYSLNQHSNWVRSAKFSPDGRL--IVSGSDDRTVRVWDSNSRECVHTFYE--HGGFVNQVDFHPSGTCIAAAGTDNTVKVWDIRMNKLLQHY---QVHGAAVNSLSFHPTGNYLITASNDSTLKVLDLVEGRLFYTLH-GHQG-PATAVAFSRAGDFFASGGSDEQVMVWK 298          

Query:  514 RTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSN---------------------------------------PSVK---KAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDT 1146
            R    H+  ++ VDF  +PN++ LASGS D  + +++F                                         PSVK     FK+    + VR++ F + G  L+  +  K+++++ V+  +   S    +QH+  +    +SP+  +  S S D + ++WD  S  C++TF + H GF ++ V F  +   +  +G D+ VK+W++   + L  Y   G     L      F+ T +Y++    D+
Sbjct:   12 RHFKGHRDTITSVDF--NPNMKQLASGSMDACLMVWNFKPQTRAYRFVGHKDAVMSVQFSPSGHLVVSASRDKTVRLWVPSVKGESTVFKA--HTATVRSVSFSADGQSLVTASDDKSIKVWTVHRQKFLYSL---NQHSNWVRSAKFSPDGRLIVSGSDDRTVRVWDSNSRECVHTFYE-HGGF-VNQVDFHPSGTCIAAAGTDNTVKVWDIRMNKLLQHYQVHGAAVNSL-----SFHPTGNYLITASNDS 250          

Query:  802 HNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLL-SLN-HNGAVRCFVHSPTTAAFLSCSDDNRARFW 1293
            H   I  V ++PN    AS S+D    +W+         F    +   + SVQFS +   ++++ +D  V+LW  S       +     T R +  S       +   +    D KS+  W      RQ+ L SLN H+  VR    SP     +S SDD   R W
Sbjct:   17 HRDTITSVDFNPNMKQLASGSMDACLMVWNFKPQTRAYRFVGHKDA--VMSVQFSPSGHLVVSASRDKTVRLWVPSVKGESTVFKAHTATVRSVSFSA------DGQSLVTASDDKSIKVW---TVHRQKFLYSLNQHSNWVRSAKFSPDGRLIVSGSDDRTVRVW 171          

Query:  313 ETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTF-EKAH-----------------EGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKR 1302
            E   ++ H++      F+    ++ + SED++IK+ D E                       T    RTL  H   V  + F  D + ++LAS S D T+KL+DF +    +          V ++ F  +GD L+  +  KT+++++V T  C  +      H   + MV  + + S+ ASCS D + ++W   +  C     E  H                 E     + +  +   YLL+  +D  +K+W++STG C+I   G     R       V  H     +    D K+L  WD +    Q+ L+ + +       H  T    ++ S D   + W  R
Sbjct:   39 EKYALSGHRSPVTRVIFHPVFSVIVSASEDATIKVWDYE-----------------------TGDFERTLKGHTDSVQDISF--DLSGKMLASCSADMTVKLWDFQSFECLRTMHG--HDHNVSSVAFMPNGDHLVSASRDKTMKMWEVQTGYCVKTFT---GHREWVRMVRPNQDGSLIASCSNDQTVRVWVTATKECKAELREHEHVVECVSWAPDAASPVILEATGAEAKKGGKPGPYLLSGSRDKTIKMWDISTGICVITLVGHDNWVR------GVLFHPGGKFILSCADDKTLRVWDYKNKRCQKSLAAHEHFVTSLDFHK-TAPYVITGSVDQSVKVWECR 349          

Query:  508 VIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSS--GDC--------LLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSC--AVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDD 1275
            + +TL  H+  VS +  HP    +I+ + S D   K++            SIP    + T + H+   GDC        L  G    T++++D +   C ++    + H  A+   +W       AS S+D S K+WD  S RC  T  + H    ++SV+F   S  LLTS  D  + LW+  TGRC   + G       LH SC    FN   D V+  D     +  WD RK      L+L  + A R   H P+       SDD
Sbjct:  327 ISQTLKAHEMPVSSMALHP--RKEIIVTASDDQLWKMW------------SIPNGDIIMTGQGHTDWIGDCDFNPTGTNLATGGGDSTVKVWDFSQGACVLTL---EGHGHAVWGCSWHSCGDFIASSSMDNSSKVWDVNSERCRQTL-RGHTD-SVNSVEFLPYSSTLLTSSADKTLSLWDARTGRCAQIFYG------HLH-SCNHGTFNLKGDTVVSCDS-YGVIKVWDVRKGTATMTLNLGPHPANRLSFH-PSGHVMAVASDD 566          

Query:  529 HQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHS---SGD-------------CLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHE-----------GFPISSVQ-FSRNSKYLLTSGKDSIVKLWELS---TGRCL-IEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLS-LNHNGAVRCFVHSPTTAAFLSCSDDNRARFW 1293
            H   V C  F+PD +L  LA+ S + T  L+D                S VR   F      GD             CLL G+   TL ++DV   +C   A  +D   G+++   +SP    F + S  G   +WD V+ RC++T   AH+             P++ V+ F      + + G+D+ + LW L+   TG CL + +   G T   L   C  F+ ++ +V+      KS+  W+      ++LLS + H   V     +P     ++ S D   + W
Sbjct:   53 HTYAVHCCCFNPDGSL--LATCSTEGTTALWDARTGQRITVLLQPGGGSGVRVCAFSPRPLGGDAGQAPATAAPPVECLLSGSTDGTLALWDVRAHRCLKVASLKD---GSVSGCAFSPCGRAFVTGSTIGELSVWDAVNMRCLHTTRSAHDLGVTAVSFSPPPRPVAGVERFETQRSIMASCGQDNKIALWTLALDRTGDCLTLRFCLEGHTAPVL---CCCFS-SDGHVLASGSVDKSVILWNPITG--EKLLSIMEHQRYVTSCAFTPGAPYLITGSMDKTVKLW 329          

Query:  520 LYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYH-KTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFW 1293
             Y +QA+V CV FHP   L  LA G      +L+D  + ++ +        +PV T+  + +G+ L  G+     L +Y+  +    +    +  H  + N + +SP+ S   + S DG  K+WD  S  C+ TFE+      +++VQF++  + + +S  D  V+ W+L   R    +TG      ++  +C   + + + V     D   +  W  +       LS  H G V C   S   +   S S D   R W
Sbjct:  256 FYANQAKVKCVTFHPATRL--LAVGFTSGEFRLYDLPDFTLIQQLSM--GQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILK---QQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSS--VTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGT----ERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS-GHEGPVSCLSFSQENSVLASASWDKTIRIW 500          

Query:  568 PNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMF-ASCSVDGSFKIWDGVSCRCINTFEKAHEGF-----PISSVQFSRNSKYLLTSGKDSIVKLWEL------------STGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHS-----PTTAAFLSCSDDNRARFWYKRPIS 1311
            P+ + LA+G++D  I+++D  N  +    +       + ++ +  SGD L+ G+  +T+RI+D+ T QC ++   ED     +  V  SP    + A+ S+D + ++WD  +   +   +  +E        + SV F+R+ + +++   D  VKLW L            ++G C + Y G     +    S A   + E Y++   +D + +  WD +  +   +L  + N  +   V +     P    F + S D +AR W  + I+
Sbjct:  453 PDGKFLATGAEDRLIRIWDIENRKIVMILQG--HEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIED----GVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGH----KDFVLSVATTQNDE-YILSGSKD-RGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYKKIA 711          

Query:  568 PNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPN-SSMFASCSVDGSFKIWDGVSCRCINT------FEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAV-FNHTEDY---VMFPDEDTKSLCCWDSRKADRQRLL--SLNHNG----AVRCF 1230
            P+ Q +A+ S D+++++   S   +      I   +PV ++ F+  G+ L   +  ++++I+D        +      H+ A+  V    N SS+ +S S DG  +I+D  +  C+ T      +++ +   PIS V+FS N++YLL    D +VK+W+   G  +  +         LH SC + F + ED    ++    +   + CW+S      +LL  SL H+     ++ CF
Sbjct:   65 PDGQCIATASDDFSVEIIHLSYGLLHTF---IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI---SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF 296          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPE---DQHNGA--INMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFE 924
            VT+H        ++  GQ +AT S+D S++I+ +                        ++ ++ T   H A V  + F+   NL  L + S D +IK++D  N S+ K   +  EA     +  + S   L  G+Y   +RI+D  T  C  +   +    + NG   I+ V +S N+      S+DG  KIWD +    + TF+
Sbjct:   51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHL------------------------SYGLLHTFIGHTAPVISLTFNRKGNL--LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS-SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228          

Query:  502 HPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPS--VKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWEL 1026
             P+ + L  H  ++  +D+HPD N Q++ S ++D  IK F +SN    ++     +     +  +K+H SG  +   ++  T R++D +T Q     + ++ H+  +  +++  + S+  S  +D    +WD  S   + T   A    PI +V +S N   + T G D I+ +W++
Sbjct:  208 QPLTQKLDSHVGKIGAIDWHPDSNNQMI-SCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQEL---LLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTL--AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDI 378          

Query:  529 HQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQ----------------------------------------------HNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            H+  V+ V F  D   + + + S+D TIK++D  +PS+ + +K     +PV  +  H +   L+       +RI+D+   QC     PED                                               H+  I  +  S +    A+CS D + ++W       + T    H+ + +    FS +S YL+T+  D  V+LW+LST   + +Y G
Sbjct:   74 HRGNVTSVSFQQDN--RWMVTSSEDGTIKVWDVRSPSIPRNYK---HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRW-VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDE--ADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWY 1296
            K R+ LY+LIISQL +DG +  A  +  T N  +   P  RLL+++ LGL+   +   A    L  D  T   G+DL+ E+++ +  P AA+YET YVTAHKA CRAA+F+  G+LVATGS DSSIK+LDV+RM+AK+  P   +  + Q   +E HPVIRTLYDH  EV+ ++FHP     +L SGSKD T+KLFD S PSVKKA+K++ EA  + ++ FH SGD +LV T H T+R+YDVNT QCFV + P + H   + MV ++P+++++ASCS DGS KIWDGVS RC+ TF KAH G  I SVQFS NSKY+++SGKDS+V LWEL+TGR +  YTG+  T    +R+ A+FNHTED+++  DE   S+ CWD+R  ++ + L   HN  +RC  HSP  AAF+SCSDD RARFWY
Sbjct:    6 KQRETLYKLIISQLHYDGCEAVAAALAKTTNIISPCPPCARLLEIVNLGLAAEAEGIVAHLLTLANDLAT--KGIDLEYESDAHSTTPPAAIYETYYVTAHKAPCRAASFSPNGKLVATGSVDSSIKVLDVDRMVAKNTMP--QVHDQGQGMNLENHPVIRTLYDHAEEVTALEFHP--CAPVLISGSKDCTVKLFDISKPSVKKAYKAVQEAEVINSMSFHPSGDFVLVSTEHPTIRLYDVNTFQCFVPSNPREYHTEPVTMVKYAPSANLYASCSNDGSIKIWDGVSNRCVATFPKAHNGAEIFSVQFSFNSKYVISSGKDSLVYLWELATGRAVNMYTGSTMTN---YRTQAIFNHTEDFILVADEKNSSISCWDTRTTEKLKALPSGHNNHIRCLTHSPVGAAFVSCSDDFRARFWY 417          

Query:  313 ETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVF-NHTED 1119
            E+    AH A  R+  F+  GQ + T S+D S+K+  V R                          + +L  H   V C  F PD  L  + SGS D TIKL+D ++      F        V +++FH SG C+  G    T++++D+   +          H GA+N V++ P+ +   S S D + KI D +  R   T    H+G P +SV FSRN +Y  +   D  V +W+ +  +  ++Y     T R+  R+  V  +HT D
Sbjct:   94 ESTVFKAHTATVRSVDFSGDGQSLLTASDDKSLKVWTVHRQ-----------------------KFLYSLNAHMNWVRCAKFSPDGRL--IVSGSDDKTIKLWDRTSKDCVHTFYD--PGGFVNSVEFHPSGTCIAAGGTDSTVKVWDIRMNKLLQHY---QAHTGAVNSVSFHPSGNYLVSASSDTTLKILDLMEGRLFYTLH-GHQG-PATSVVFSRNGEYFASGSSDEQVMVWKTNFDK--VDYQEVLRTHRK--RAAPVSPSHTHD 327          

Query:  322 YVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRT--LYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVK---KAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEY---TGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSL--NHNGAVRCFVHSPTTAAFLSCSDDNRARFW 1293
            +   H+    +  FN   + + TGS DSS+ I   +                         P +R      H+  +  V F P  +L  +AS S+D T++L+    PSVK     FK+    + VR++ F   G  LL  +  K+L+++ V+  +   S    + H   +    +SP+  +  S S D + K+WD  S  C++TF     GF ++SV+F  +   +   G DS VK+W++   + L  Y   TGA         +   F+ + +Y++    DT +L   D  +    RL      H G     V S     F S S D +   W
Sbjct:   13 HFKGHRDTVTSVDFNPNMKQLVTGSMDSSLMIWHFK-------------------------PHMRAYRFVGHKDAILSVKFSPSGHL--IASASRDKTVRLW---VPSVKGESTVFKA--HTATVRSVDFSGDGQSLLTASDDKSLKVWTVHRQKFLYSL---NAHMNWVRCAKFSPDGRLIVSGSDDKTIKLWDRTSKDCVHTFYDP-GGF-VNSVEFHPSGTCIAAGGTDSTVKVWDIRMNKLLQHYQAHTGA--------VNSVSFHPSGNYLVSASSDT-TLKILDLMEG---RLFYTLHGHQGPATSVVFSRNGEYFASGSSDEQVMVW 297          

Query:  310 YETCY-VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            Y+  Y +T H  A  +  F+  G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D   + L S S D T+K++DF+     K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  +  V ++ + ++  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:   55 YQLKYTLTGHNKAVSSVKFSHNGEWLASSSADKVIKIW----------GAYDGKFE-------------KTITGHKLGISDVAWSTDS--RHLVSASDDKTLKIWDFATGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLPA--HSDPVTAVHFNRDGALIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 274          

Query:  499 THPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWEL 1026
            T  VI TL  H  +++ V +HP   L I AS   D TI+++  +  S +   K+  +A  V  +  H++GD LL  +  +     D+ T +     + +   N  +    + P+  +F + + D   KIWD      +  F   H G PIS + FS N  YL TS  DS+VKLW+L
Sbjct:  256 TEQVIATLKGHTKKITNVIYHPTEELGITASA--DSTIRVWSITKGSCEHILKAHDQA--VTGLSLHATGDYLLSCSADQHWAFSDIRTGRVLTKCISDPAVNQGLTCAQFHPDGLIFGTGTSDSIIKIWDLKERTNVAKF-PGHSG-PISDITFSENGYYLATSADDSVVKLWDL 425          

Query:  319 CYVT--AHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCL 1044
            CY T   H A     AFN    ++ATGS D++ K+ DV+                       T   I TL  H AE+    F+     Q+L +GS D+T+ ++D    S ++    I     +   +F+     ++ G+  KT +I+D  T +C  +      H+  +  V +     + A+ S DG+ ++++ ++  C++  E  HEG  IS + F+     LLT+  D   +LW+ +TG+CL
Sbjct:  169 CYHTYRGHSAEIVCLAFNPQSTVIATGSMDTTAKLWDVQ-----------------------TGAEISTLSGHSAEIISCAFNS-TGTQLL-TGSFDHTVSVWD--TRSGRRVHTLIGHRGEISNAQFNFDCSFIVTGSMDKTCKIWDAGTGKCIGTL---RGHDDEVLDVAFDYTGQLIATASADGTGRVYNALTHHCLSKLE-GHEG-EISKITFNAQGTRLLTASSDKTARLWDPNTGKCL 380          

Query:  313 ETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWE 1023
            E   ++ H A   + AFN+TG  + TGS D ++ + D      +SG                    + TL  H+ E+S   F+ D +   + +GS D T K++D          +       V  + F  +G  +   +   T R+Y+  T  C       + H G I+ +T++   +   + S D + ++WD  + +C+   E   +   I S  F+ +   ++T  KD+  +LW 
Sbjct:  211 EISTLSGHSAEIISCAFNSTGTQLLTGSFDHTVSVWDT-----RSG------------------RRVHTLIGHRGEISNAQFNFDCSF--IVTGSMDKTCKIWDAGTGKCIGTLRG--HDDEVLDVAFDYTGQLIATASADGTGRVYNALTHHCLSKL---EGHEGEISKITFNAQGTRLLTASSDKTARLWDPNTGKCLQVLEGHTD--EIFSCAFNYDGDIIITGSKDNTCRLWR 415          

Query:  313 ETCYVTAHKAACRAAAFN-ATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCL 1044
            ET  +  HK    A AFN   G  +ATGS D + K+ + E                       T     T   H AE+ C+ F+P     ++A+GS D T KL+D    +          ++ + +  F+S+G  LL G++                                             D +  +WD  S R ++T    H G  IS+ QF+ +  +++T   D   K+W+  TG+C+
Sbjct:  126 ETLTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWNAE-----------------------TGKCYHTYRGHSAEIVCLAFNPQST--VIATGSMDTTAKLWDVQTGAEISTLSG--HSAEIISCAFNSTGTQLLTGSF---------------------------------------------DHTVSVWDTRSGRRVHTL-IGHRG-EISNAQFNFDCSFIVTGSMDKTCKIWDAGTGKCI 296          

Query:   40 KDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            KDR  LY+LIISQLL+DGY + A  ++  V P     PS +L++L ++G+   D        + D++ PG G+D++ + +  TM+PEA+ YETCYVT+HK  CR A ++  GQL+ATGS D+SIKILD ERMLAKS  PI+ M  E  QQ ME HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFVS  P DQH   I+ V+++P+++ + SCS DGS K+WDGVS RC+ TFEKAH+G  + S  FS+NSKY+L+SGKDS+VKLWE+STGR L++YTGAG +GRQ+HR+  VFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:    9 KDRQQLYKLIISQLLYDGYTSIANSLINEVKPQNVVSPSEQLMQLAKIGMENDDSAVQYAIGRSDTVAPGVGIDMEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFVSCNPLDQHTDTISGVSYNPSANSYVSCSKDGSIKLWDGVSNRCVTTFEKAHDGAEVCSAIFSKNSKYVLSSGKDSVVKLWEISTGRTLVKYTGAGLSGRQMHRTQGVFNHTEDYVLLPDERTISLCCWDSRTAERKNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRTTTD 431          

Query:  502 HPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            HPVIRTLYDH  EV+C+ FHP    QILASGS+DYT+KLFD+S PS K+AFK I EA  +R+I FH SGD LLVGT H TLR+YDVNT QCFVS  P DQH   I+ V+++P+++ + SCS DGS K+WDGVS RC+ TFEKAH+G  + S  FS+NSKY+L+SGKDS+VKLWE+STGR L++YTGAG +GRQ+HR+  VFNHTEDYV+ PDE T SLCCWDSR A+R+ LLSL HN  VRC VHSPT   F++CSDD RARFWY+R  +D
Sbjct:   67 HPVIRTLYDHVDEVTCLAFHPTE--QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFLLVGTQHPTLRLYDVNTFQCFVSCNPLDQHTDTISGVSYNPSANSYVSCSKDGSIKLWDGVSNRCVTTFEKAHDGAEVCSAIFSKNSKYVLSSGKDSVVKLWEISTGRTLVKYTGAGLSGRQMHRTQGVFNHTEDYVLLPDERTISLCCWDSRTAERKNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRTTTD 335          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            +  H  A  +  F+ +G+ +A+ S D  IKI           G  D   +             +T+  H+  +S V +  D NL  L S S D T+K++D ++    K  K    ++ V    F+   + ++ G++ +++RI+DV T +C +  +P   H+  ++ V ++ + S+  S S DG  +IWD  S +C+ T     +  P+S V+FS N KY+L +  D+ +KLW+ S G+CL  YTG
Sbjct:   41 LAGHTKAVSSVKFSPSGEWLASSSADKLIKIW----------GAYDGKFE-------------KTISGHKLGISDVAWSSDSNL--LVSASDDKTLKIWDVNSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSI-VKLWELSTGRCL 1044
            +T HK A     F+ + + VA GS+  SI++ D+E                          +++TL  H+A ++ + FH  P  Q LAS S D  IKL+D         FK   +A  VR++ F   G  L   +   T++++D++  +          H+ A+N+V + PN  + AS S D S ++WD      I T E       I  V FS +   L +   DS+ V  WE    RC+
Sbjct:   59 LTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDLE-----------------------AAKILQTLMGHKASITSLGFH--PYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDA--VRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEF---KSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSA--IRCVCFSPDGSCLFSGATDSLRVFGWE--PDRCI 265          

Query:  529 HQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCA--VFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYK 1299
            H   VSC+        ++LA+G +D  + L+  +  +   +       + V  I+F  S + +  G+   ++R++D+   +   + +    H  +I  + + P     AS S+D + K+WD      +  F K H    + S+ FS + K+L ++  D  VKLW+LS G+ + E+          H +    V  H  +Y++      +S+  WD  K      L      A+RC   SP  +   S + D+   F ++
Sbjct:   19 HARPVSCLALGKSTG-RLLATGGEDCRVNLWSLNKANCIMSLTG--HKTAVECIQFSLSEEQVAAGSQSGSIRVWDLEAAKILQTLM---GHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRF-KGHTDA-VRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKS--------HSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLE-GDTSAIRCVCFSPDGSCLFSGATDSLRVFGWE 260          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSI-VKLWELSTGRCL 1044
            +T HK A     F+ + + VA GS+  SI++ D+E                          +++TL  H+A ++ + FH  P  Q LAS S D  IKL+D         FK   +A  VR++ F   G  L   +   T++++D++  +          H+ A+N+V + PN  + AS S D S ++WD      I T E       I  V FS +   L +   DS+ V  WE    RC+
Sbjct:   59 LTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDLE-----------------------AAKILQTLMGHKASITSLGFH--PYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDA--VRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEF---KSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSA--IRCVCFSPDGSCLFSGATDSLRVFGWE--PDRCI 265          

Query:  529 HQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCA--VFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYK 1299
            H   VSC+        ++LA+G +D  + L+  +  +   +       + V  I+F  S + +  G+   ++R++D+   +   + +    H  +I  + + P     AS S+D + K+WD      +  F K H    + S+ FS + K+L ++  D  VKLW+LS G+ + E+          H +    V  H  +Y++      +S+  WD  K      L      A+RC   SP  +   S + D+   F ++
Sbjct:   19 HARPVSCLALGKSTG-RLLATGGEDCRVNLWSLNKANCIMSLTG--HKTAVECIQFSLSEEQVAAGSQSGSIRVWDLEAAKILQTLM---GHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRF-KGHTDA-VRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKS--------HSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLE-GDTSAIRCVCFSPDGSCLFSGATDSLRVFGWE 260          

Query:   34 MYKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            MYKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDNMGQENQQQQMETHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD
Sbjct:    1 MYKDRDLLYRLIISQLLFDGYQTAAIHIMTTVNPSTSSGPSNRLLKLMQLGLSISDDEADRCNLKEDSITPGTGMDLDVETESSTMAPEAALYETCYVTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDNMGQENQQQQMETHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSLNHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 427          

Query:  505 PVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            P    L  H+A ++CV FHP  N  +  SGS+D TIK++D+ +                              G Y +TLR                  H   +  + + P+  + ASCS D   K+WD V   C+ T    H+   +S V F  +  +LL++ +D  +KLWE+STG C+  + G
Sbjct:   66 PARHVLKGHRASITCVRFHPLYN--VFVSGSEDATIKIWDYES------------------------------GDYERTLR-----------------GHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLS-GHD-HNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEG 199          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFP------------------ISSVQFSRNSK-------------YLLTSG-KDSIVKLWELSTGRCLI 1047
            +  H+A+     F+    +  +GSED++IKI D E       G  +                 RTL  H   V  + F  DP+ ++LAS S D  IKL+DF   +  K          V  + F  SGD LL  +  KT+++++V+T  C  +    + H+  + +V  + + S+ ASCS D S ++W   +  C   F + HE                     +   Q + N               +LL SG +D  ++LW+ +TG CL 
Sbjct:   71 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYE------SGDYE-----------------RTLRGHTNHVQDLAF--DPSGKLLASCSADMQIKLWDFVEFTCVKTLSG--HDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTF---EGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDF-REHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLF 312          

Query:  505 PVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTG 1059
            P    L  H+A ++CV FHP  N  +  SGS+D TIK++D+ +                              G Y +TLR                  H   +  + + P+  + ASCS D   K+WD V   C+ T    H+   +S V F  +  +LL++ +D  +KLWE+STG C+  + G
Sbjct:  100 PARHVLKGHRASITCVRFHPLYN--VFVSGSEDATIKIWDYES------------------------------GDYERTLR-----------------GHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLS-GHD-HNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEG 233          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFP------------------ISSVQFSRNSK-------------YLLTSG-KDSIVKLWELSTGRCLI 1047
            +  H+A+     F+    +  +GSED++IKI D E       G  +                 RTL  H   V  + F  DP+ ++LAS S D  IKL+DF   +  K          V  + F  SGD LL  +  KT+++++V+T  C  +    + H+  + +V  + + S+ ASCS D S ++W   +  C   F + HE                     +   Q + N               +LL SG +D  ++LW+ +TG CL 
Sbjct:  105 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYE------SGDYE-----------------RTLRGHTNHVQDLAF--DPSGKLLASCSADMQIKLWDFVEFTCVKTLSG--HDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTF---EGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDF-REHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLF 346          

Query:  529 HQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVK-KAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRLLSL--NHNGAVRCFVHSPTTAAFLSCSDDNRARFWYKRPISD 1314
            H+  +  V F   P  Q++AS S+D T++L+    PS+K ++       + VR++        ++ G+  KT++++ ++  Q F  ++ E  H   +  V +S +  + AS S D + K+WD  +  CI+TF++ H GF + S+ F  N  Y+ + G DS V +W++   + L  YT   +         AV  H     +    D  S+  +D  +    RLL     H G +     S     F S   D++   W    +S+
Sbjct:   55 HEDAILSVKF--SPTGQLVASASRDKTVRLW---VPSIKGESLVFRAHTATVRSVDISCDNLEMVTGSDDKTIKVWKMHR-QKFSYSLNE--HKNWVRCVRFSSDGQLIASSSDDKTIKLWDRHNQECIHTFQE-HGGF-VPSLAFHPNGSYIASGGTDSHVNIWDIRMNKLLQHYTSHTSP------VNAVSFHPSGNFLISSSDDSSMKIYDLLEG---RLLYTVQGHEGPILGTAFSHCGEMFASGGADHQVFLWQAGQLSE 300          

Query:  325 VTAHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIW 888
            +  HK   R   F++ GQL+A+ S+D +IK+ D                             I T  +H   V  + FH  PN   +ASG  D  + ++D     + + + S    SPV  + FH SG+ L+  +   +++IYD+   +   +      H G I    +S    MFAS   D    +W
Sbjct:  136 LNEHKNWVRCVRFSSDGQLIASSSDDKTIKLWD-----------------------RHNQECIHTFQEHGGFVPSLAFH--PNGSYIASGGTDSHVNIWDIRMNKLLQHYTS--HTSPVNAVSFHPSGNFLISSSDDSSMKIYDLLEGRLLYTV---QGHEGPILGTAFSHCGEMFASGGADHQVFLW 293          

Query:  802 HNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVMFPDEDTKSLCCWDSRKADRQRL-LSLN-HNGAVRCFVHSPTTAAFLSCSDDNRARFW 1293
            H   +  V ++PNSS  AS  +D    IW+         F   HE   I SV+FS   + + ++ +D  V+LW  S     + +     T R +  SC      ++  M    D K++  W   K  RQ+   SLN H   VRC   S       S SDD   + W
Sbjct:   13 HKDKVTCVDFNPNSSQLASGGIDSCLMIWNFKPQTRAYRF-VGHED-AILSVKFSPTGQLVASASRDKTVRLWVPSIKGESLVFRAHTATVRSVDISC------DNLEMVTGSDDKTIKVW---KMHRQKFSYSLNEHKNWVRCVRFSSDGQLIASSSDDKTIKLW 167          

Query:  517 TLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCRCINTFEKAHEGFPISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFN 1107
            T+  H+  V+C+  H   N ++  + S D + KL+   +  V    K     + V    F + G+ L   +   TL+I++++  +C  +    + H+ +I  V W  ++   A+ S D + K+WD  S +C  T  + H    ++SVQF  NS  LLTS  D  V LW+     C     G   +G Q   + A  N
Sbjct:  306 TIKAHEGAVTCIRTHK--NKKVFCTTSDDDSWKLWSLDSLQVLMTGKG--HTNWVSCAAFDNDGEKLATTSGDTTLKIWNLSAAECLYTF---EGHSQSIWSVDWHTSAPFLATASHDKTIKVWDLNSLKC-RTILRGHSD-SVNSVQFLVNSNILLTSSADKTVCLWDARISTC-----GQSISGHQYAVNSANIN 488          

Query:  331 AHKAACRAAAFNATGQLVATGSEDSSIKILDVERMLAKSGGPIDXXXXXXXXXXXXTHPVIRTLYDHQAEVSCVDFHPDPNLQILASGSKDYTIKLFDFSNPSVKKAFKSIPEASPVRTIKFHSSGDCLLVGTYHKTLRIYDVNTTQCFVSAVPEDQHNGAINMVTWSPNSSMFASCSVDGSFKIWDGVSCR----CINTFEKAHEGF-PISSVQFSRNSKYLLTSGKDSIVKLWELSTGRCLIEYTGAGTTGRQLHRSCAVFNHTEDYVM 1128
             H      AAF+  G+ +AT S D+++KI ++                            + T   H   +  VD+H   +   LA+ S D TIK++D ++   +   +    +  V +++F  + + LL  +  KT+ ++D   + C  S      H  A+N    +   +  ASC   G  K WD   CR     INT +    GF P + V++  +   +  S  DS++K+ E ++      +      G +     A+F+H  ++++
Sbjct:  351 GHTNWVSCAAFDNDGEKLATTSGDTTLKIWNL-----------------------SAAECLYTFEGHSQSIWSVDWHT--SAPFLATASHDKTIKVWDLNSLKCRTILRG--HSDSVNSVQFLVNSNILLTSSADKTVCLWDARISTCGQSISG---HQYAVNSANINEQGTNIASCDAFGFLKFWD---CRQLATSINTIDL---GFHPANDVRYDTSGSCVAMSSSDSVIKMVETAS------FNVTSLVGHEDSVQSAMFDHDGEFLI 579