FHA domain protein

Overview
NameFHA domain protein
Smed IDSMED30027005
Length (bp)659
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of FHA domain protein (SMED30027005) t-SNE clustered cells

Violin plots show distribution of expression levels for FHA domain protein (SMED30027005) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FHA domain protein (SMED30027005) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FHA domain protein (SMED30027005) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30027005

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30027005SMESG000021239.1 SmedASXL_002074SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30027005SMESG000021239.1 SmedASXL_002074SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of FHA domain protein vs. Ensembl Human
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:30587])

HSP 1 Score: 185.267 bits (469), Expect = 2.480e-56
Identity = 88/165 (53.33%), Postives = 119/165 (72.12%), Query Frame = 3 
Query:  132 KKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
            K+ E   KE  +  L+G L E+TN ++GV I Y+EP EA  P  +WRLY FK DE LP +++HRQSAYL+G+HR I +IP+DHPS SKQHAV Q+R ++           V+PY+IDL S NG+F++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL + +  S+
Sbjct:  214 KEKEVPAKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSE 378
[Close]
BLAST of FHA domain protein vs. Ensembl Human
Match: SLC4A1AP (solute carrier family 4 member 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:13813])

HSP 1 Score: 70.0922 bits (170), Expect = 2.266e-13
Identity = 44/122 (36.07%), Postives = 67/122 (54.92%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFR------QIDA-GVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EP      T  + L + KG   L T  L   S  L G+  G C++ ++HPS+S+ HAV+Q R      + D+ G   YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  100 YQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSG-CDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFIL 220
[Close]
BLAST of FHA domain protein vs. Ensembl Human
Match: SLC4A1AP (solute carrier family 4 member 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:13813])

HSP 1 Score: 70.0922 bits (170), Expect = 2.392e-13
Identity = 44/122 (36.07%), Postives = 67/122 (54.92%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFR------QIDA-GVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EP      T  + L + KG   L T  L   S  L G+  G C++ ++HPS+S+ HAV+Q R      + D+ G   YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  154 YQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSG-CDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFIL 274
[Close]
BLAST of FHA domain protein vs. Ensembl Human
Match: SLC4A1AP (solute carrier family 4 member 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:13813])

HSP 1 Score: 70.0922 bits (170), Expect = 2.392e-13
Identity = 44/122 (36.07%), Postives = 67/122 (54.92%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFR------QIDA-GVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EP      T  + L + KG   L T  L   S  L G+  G C++ ++HPS+S+ HAV+Q R      + D+ G   YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  154 YQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSG-CDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFIL 274
[Close]
BLAST of FHA domain protein vs. Ensembl Human
Match: PPP1R8 (protein phosphatase 1 regulatory subunit 8 [Source:HGNC Symbol;Acc:HGNC:9296])

HSP 1 Score: 68.5514 bits (166), Expect = 5.116e-13
Identity = 37/116 (31.90%), Postives = 64/116 (55.17%), Query Frame = 3 
Query:  225 IYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            +++ P+ A  P     L   KGD+ +  + +  +  YL G++  +C+  +DH S S+ HA + + +     R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y L
Sbjct:   13 LFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLK--RVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTL 126
[Close]
BLAST of FHA domain protein vs. Ensembl Celegans
Match: C32E8.5 (pep chromosome:WBcel235:I:3782118:3783232:1 gene:WBGene00016323.1 transcript:C32E8.5.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C32E8.5)

HSP 1 Score: 183.726 bits (465), Expect = 2.395e-57
Identity = 90/167 (53.89%), Postives = 121/167 (72.46%), Query Frame = 3 
Query:  132 KKMEPVK-KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQI----DAGVR-----PYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDD 602
            K  EP K KE VN+  +G L E+TN ++GV I YNEP EA  P  +WRLY FKG+ESL  +++HRQSAYLIG+   I +IP+DHPS SKQHAV+QFR +    D G +     PY+IDL S NG+F++  KIEPQ+Y EL+E+D+LKFGFSTREYV++ ++ +  ++
Sbjct:  120 KPEEPAKEKEKVNLGTSGALTEDTNTFRGVVIKYNEPPEAKKPNARWRLYPFKGEESLQVLYIHRQSAYLIGRDHKIADIPVDHPSCSKQHAVLQFRSMPFTRDDGTKARRIMPYIIDLGSGNGTFLNEKKIEPQRYIELQEKDMLKFGFSTREYVVMKEREITEEE 286
[Close]
BLAST of FHA domain protein vs. Ensembl Celegans
Match: C32E8.5 (pep chromosome:WBcel235:I:3782118:3783294:1 gene:WBGene00016323.1 transcript:C32E8.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C32E8.5)

HSP 1 Score: 183.726 bits (465), Expect = 2.395e-57
Identity = 90/167 (53.89%), Postives = 121/167 (72.46%), Query Frame = 3 
Query:  132 KKMEPVK-KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQI----DAGVR-----PYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDD 602
            K  EP K KE VN+  +G L E+TN ++GV I YNEP EA  P  +WRLY FKG+ESL  +++HRQSAYLIG+   I +IP+DHPS SKQHAV+QFR +    D G +     PY+IDL S NG+F++  KIEPQ+Y EL+E+D+LKFGFSTREYV++ ++ +  ++
Sbjct:  120 KPEEPAKEKEKVNLGTSGALTEDTNTFRGVVIKYNEPPEAKKPNARWRLYPFKGEESLQVLYIHRQSAYLIGRDHKIADIPVDHPSCSKQHAVLQFRSMPFTRDDGTKARRIMPYIIDLGSGNGTFLNEKKIEPQRYIELQEKDMLKFGFSTREYVVMKEREITEEE 286
[Close]
BLAST of FHA domain protein vs. Ensembl Celegans
Match: B0511.7 (pep chromosome:WBcel235:I:10631665:10633150:-1 gene:WBGene00015233.1 transcript:B0511.7.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:B0511.7)

HSP 1 Score: 49.6766 bits (117), Expect = 4.337e-7
Identity = 34/135 (25.19%), Postives = 65/135 (48.15%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL--------TDKALASDDEE 608
            +  PS AA P +   L   KGD  +  + +  + AY  G++    +  ++H S S+ HA++ +  +    R  LID+ S++G+F+  +++ P +   +        G STR+Y +          D  +A+ DE+
Sbjct:   10 FKVPSWAAKPPNGAHLDVQKGDALIQKLLIDDKKAYYFGRNNKQVDFAVEHASCSRVHALLLYHGLLQ--RFALIDMDSSHGTFLGNVRLRPLEVVFMDPGTQFHLGASTRKYSVRLKTEHHVEDDPTVAASDEQ 142
[Close]
BLAST of FHA domain protein vs. Ensembl Celegans
Match: ZK632.2 (pep chromosome:WBcel235:III:9799107:9802333:1 gene:WBGene00014011.1 transcript:ZK632.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK632.2)

HSP 1 Score: 48.9062 bits (115), Expect = 1.052e-6
Identity = 25/78 (32.05%), Postives = 48/78 (61.54%), Query Frame = 3 
Query:  336 LIGKHRGICEIPMDHPSISKQHAVIQF---RQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTR 560
            +IG+ +  C++ M+HPSIS+ H ++Q+   +    G   ++ +L ST+GS ++  ++ P++Y   R   + +FG STR
Sbjct:  109 VIGRIKPGCDLLMEHPSISRYHCILQYGNDKMSKTGKGWHIFELGSTHGSRMNKKRLPPKQYIRTRVGFIFQFGESTR 186
[Close]
BLAST of FHA domain protein vs. Ensembl Fly
Match: CG17168 (gene:FBgn0039943 transcript:FBtr0113730)

HSP 1 Score: 172.555 bits (436), Expect = 1.297e-51
Identity = 81/165 (49.09%), Postives = 113/165 (68.48%), Query Frame = 3 
Query:  144 PVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQI---------DAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEED 611
            PV KE  N  L+G L E+TN   GV + Y+EP EA  P  +WRLY FKG+ +LPT+H+HRQS +L+G+ R + ++ +DHPS SKQHA +Q+R +            VR YLIDL S NG+F++  KI+ +KYYEL E+DV+KFGFS+REYVLL + +    +++D
Sbjct:  240 PVDKEKPNFGLSGALTEDTNKLNGVVVKYSEPPEARKPKRRWRLYPFKGETALPTLHIHRQSCFLVGRDRKVVDLAVDHPSCSKQHAALQYRLVPFEREDGSHGKRVRLYLIDLDSANGTFLNNKKIDARKYYELIEKDVIKFGFSSREYVLLHENSKEDQEDDD 404
[Close]
BLAST of FHA domain protein vs. Ensembl Fly
Match: NiPp1 (gene:FBgn0026402 transcript:FBtr0087058)

HSP 1 Score: 62.7734 bits (151), Expect = 2.715e-11
Identity = 36/116 (31.03%), Postives = 61/116 (52.59%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQH-AVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y+ PS A  P     L   K D+ +  + +  +  YL G++  + +  +DH S S+ H A +  + ++     YL+DL ST+G+FI  +++E  K  +L+      FG STR Y+L
Sbjct:    5 YDIPSWAGKPPTGLHLDVLKDDKLVQKLMVDEKRCYLFGRNSQMNDFCIDHASCSRVHSAFVYHKHLNIA---YLVDLGSTHGTFIGTLRLEAHKPTQLQINSTFHFGASTRNYIL 117
[Close]
BLAST of FHA domain protein vs. Ensembl Fly
Match: CG7706 (gene:FBgn0038640 transcript:FBtr0083667)

HSP 1 Score: 53.5286 bits (127), Expect = 4.101e-8
Identity = 40/143 (27.97%), Postives = 71/143 (49.65%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSF---KGDESLPTIH-LHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP------------------------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y  P  +A P +  ++YSF   K  + + T+H L +Q+ +  G+     ++P  HP+IS+ H V+Q++   A  +P                        Y+ D+ ST+G+F++  ++ P+ Y  +R   +LK G STR Y+L
Sbjct:   50 YKVPKWSAPPAEN-QIYSFEVLKSGQIIDTVHQLQQQAVWTFGRLPE-NDVPAAHPTISRFHVVLQYKP-KAPPKPETAKEDDEMEEEDEEPKNDQPEGWYIYDMGSTHGTFLNKQRVPPKVYIRMRVGHMLKLGGSTRVYIL 189
[Close]
BLAST of FHA domain protein vs. Ensembl Zebrafish
Match: snip1 (Smad nuclear interacting protein [Source:ZFIN;Acc:ZDB-GENE-041026-3])

HSP 1 Score: 181.8 bits (460), Expect = 7.007e-57
Identity = 86/152 (56.58%), Postives = 113/152 (74.34%), Query Frame = 3 
Query:  147 VKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID-------AG--VRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
             +KE  N  L+G L E+TN ++G  I YNEP EA  P  +WRLY FK DE LP +++HRQSAYL+G+ R I +IP+DHPS SKQHAV Q+R ++       AG  V+PY+IDL S NG++++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL
Sbjct:   84 AEKEKPNFELSGALVEDTNTFRGEVIKYNEPPEARIPKRRWRLYPFKNDEPLPVMYIHRQSAYLLGRLRKIADIPIDHPSCSKQHAVFQYRLVEFTRVDGTAGRRVKPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVLL 235
[Close]
BLAST of FHA domain protein vs. Ensembl Zebrafish
Match: snip1 (Smad nuclear interacting protein [Source:ZFIN;Acc:ZDB-GENE-041026-3])

HSP 1 Score: 183.726 bits (465), Expect = 2.669e-56
Identity = 86/152 (56.58%), Postives = 113/152 (74.34%), Query Frame = 3 
Query:  147 VKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID-------AG--VRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
             +KE  N  L+G L E+TN ++G  I YNEP EA  P  +WRLY FK DE LP +++HRQSAYL+G+ R I +IP+DHPS SKQHAV Q+R ++       AG  V+PY+IDL S NG++++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL
Sbjct:  197 AEKEKPNFELSGALVEDTNTFRGEVIKYNEPPEARIPKRRWRLYPFKNDEPLPVMYIHRQSAYLLGRLRKIADIPIDHPSCSKQHAVFQYRLVEFTRVDGTAGRRVKPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVLL 348
[Close]
BLAST of FHA domain protein vs. Ensembl Zebrafish
Match: slc4a1ap (solute carrier family 4 member 1 adaptor protein [Source:ZFIN;Acc:ZDB-GENE-080521-2])

HSP 1 Score: 75.0998 bits (183), Expect = 2.742e-15
Identity = 47/124 (37.90%), Postives = 69/124 (55.65%), Query Frame = 3 
Query:  222 IIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFR--QIDAGVRP-----YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            + Y EP   A P   +     K    L T+ L  +S +++G+   +C++ ++HPSIS+ HAV+Q+R      GV       Y  DL ST+G+FI+  KI P+ Y  LR   VLKFG STR ++L
Sbjct:  137 LPYTEPPWGAVPDINYSFELLKNGAILDTVPLTHRSYFVVGR-LPVCDVSLEHPSISRYHAVVQYRGRAGQEGVVGEERGFYAYDLGSTHGTFINKNKIPPKTYIRLRVGHVLKFGGSTRLFIL 259
[Close]
BLAST of FHA domain protein vs. Ensembl Zebrafish
Match: ppp1r8b (protein phosphatase 1, regulatory subunit 8b [Source:ZFIN;Acc:ZDB-GENE-040426-1271])

HSP 1 Score: 68.9366 bits (167), Expect = 1.934e-13
Identity = 39/116 (33.62%), Postives = 64/116 (55.17%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQF-RQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            ++ PS A  P     L   KGD+ +  + +  +  YL G++  IC+  +DH S S+ HA + + R +    R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y +
Sbjct:   12 FDCPSWAGKPPAGLHLDVVKGDKLVEKLIIDEKKFYLFGRNPDICDFTIDHQSCSRVHAALVYHRHLK---RLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTI 124
[Close]
BLAST of FHA domain protein vs. Ensembl Zebrafish
Match: ppp1r8b (protein phosphatase 1, regulatory subunit 8b [Source:ZFIN;Acc:ZDB-GENE-040426-1271])

HSP 1 Score: 68.9366 bits (167), Expect = 1.972e-13
Identity = 39/116 (33.62%), Postives = 64/116 (55.17%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQF-RQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            ++ PS A  P     L   KGD+ +  + +  +  YL G++  IC+  +DH S S+ HA + + R +    R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y +
Sbjct:   12 FDCPSWAGKPPAGLHLDVVKGDKLVEKLIIDEKKFYLFGRNPDICDFTIDHQSCSRVHAALVYHRHLK---RLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTI 124
[Close]
BLAST of FHA domain protein vs. Ensembl Xenopus
Match: snip1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:394485])

HSP 1 Score: 189.119 bits (479), Expect = 3.349e-58
Identity = 87/160 (54.37%), Postives = 119/160 (74.38%), Query Frame = 3 
Query:  147 VKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID-------AG--VRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
              KE  N  L+G L E+TN ++GV I Y+EP EA TP  +WRLY FK DE+LP +++HRQSAYL+G+ R I +IP+DHPS SKQHAV+Q+R +        +G  VRPY+IDL S NG++++  +IEPQ+YYEL+E+DVLKFGFS+REYV+L + +  S+
Sbjct:  191 ANKEKPNFELSGALLEDTNTFRGVVIKYSEPPEARTPKKRWRLYPFKNDEALPVMYIHRQSAYLLGRQRRIADIPIDHPSCSKQHAVLQYRMVQFTRANGTSGRRVRPYIIDLGSGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVVLHESSDTSE 350
[Close]
BLAST of FHA domain protein vs. Ensembl Xenopus
Match: alkbh7 (alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693])

HSP 1 Score: 72.4034 bits (176), Expect = 3.014e-14
Identity = 47/137 (34.31%), Postives = 74/137 (54.01%), Query Frame = 3 
Query:  222 IIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS 614
            I Y EP  +  P   + L   KG   + T +L   S  + G+    C + ++HPS+S+ HAV+Q+R +  G  P      Y+ DL ST+G+F++  +I+ + Y  +R   VLKFG STR ++L   +    D EE+S
Sbjct:   43 IPYREPPWSGLPEALYCLEILKGGSIVSTKNLGNVSWTVFGRLPS-CHVSLEHPSVSRYHAVLQYRHVQ-GSGPDEEPGFYVYDLGSTHGTFLNKQRIQAKTYCRIRVGHVLKFGGSTRLFIL---QGPEEDQEEES 174
[Close]
BLAST of FHA domain protein vs. Ensembl Xenopus
Match: alkbh7 (alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693])

HSP 1 Score: 70.4774 bits (171), Expect = 1.327e-13
Identity = 47/137 (34.31%), Postives = 74/137 (54.01%), Query Frame = 3 
Query:  222 IIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS 614
            I Y EP  +  P   + L   KG   + T +L   S  + G+    C + ++HPS+S+ HAV+Q+R +  G  P      Y+ DL ST+G+F++  +I+ + Y  +R   VLKFG STR ++L   +    D EE+S
Sbjct:  310 IPYREPPWSGLPEALYCLEILKGGSIVSTKNLGNVSWTVFGRLPS-CHVSLEHPSVSRYHAVLQYRHVQ-GSGPDEEPGFYVYDLGSTHGTFLNKQRIQAKTYCRIRVGHVLKFGGSTRLFIL---QGPEEDQEEES 441
[Close]
BLAST of FHA domain protein vs. Ensembl Xenopus
Match: ak6 (adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972292])

HSP 1 Score: 69.707 bits (169), Expect = 1.408e-13
Identity = 40/118 (33.90%), Postives = 64/118 (54.24%), Query Frame = 3 
Query:  219 KIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            K I+  PS A  P     L   KGD+ +  + +  +  YL G++  IC+  +DH S S+ H+ + + +     R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y L
Sbjct:    9 KPIFECPSWAGKPPQGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDICDFTIDHQSCSRVHSALVYHKHLK--RVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTISFGASTRMYTL 124
[Close]
BLAST of FHA domain protein vs. Ensembl Xenopus
Match: alkbh7 (alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693])

HSP 1 Score: 70.0922 bits (170), Expect = 2.338e-13
Identity = 47/137 (34.31%), Postives = 74/137 (54.01%), Query Frame = 3 
Query:  222 IIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS 614
            I Y EP  +  P   + L   KG   + T +L   S  + G+    C + ++HPS+S+ HAV+Q+R +  G  P      Y+ DL ST+G+F++  +I+ + Y  +R   VLKFG STR ++L   +    D EE+S
Sbjct:  389 IPYREPPWSGLPEALYCLEILKGGSIVSTKNLGNVSWTVFGRLP-SCHVSLEHPSVSRYHAVLQYRHVQ-GSGPDEEPGFYVYDLGSTHGTFLNKQRIQAKTYCRIRVGHVLKFGGSTRLFIL---QGPEEDQEEES 520
[Close]
BLAST of FHA domain protein vs. Ensembl Mouse
Match: Snip1 (Smad nuclear interacting protein 1 [Source:MGI Symbol;Acc:MGI:2156003])

HSP 1 Score: 185.267 bits (469), Expect = 1.128e-56
Identity = 86/158 (54.43%), Postives = 116/158 (73.42%), Query Frame = 3 
Query:  153 KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
            KE  +  L+G L E+TN ++GV I Y+EP EA  P  +WRLY FK DE LP +++HRQSAYL+G+HR I +IP+DHPS SKQHAV Q+R ++           V+PY+IDL S NG+F++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL + +  S+
Sbjct:  208 KEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSE 365
[Close]
BLAST of FHA domain protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 70.8626 bits (172), Expect = 7.134e-14
Identity = 43/122 (35.25%), Postives = 64/122 (52.46%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP-------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EPS  +  T  + L + KG   L T  L   S    G+    C+I ++HPS+S+ HAV+Q R  D            YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRL-ASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFIL 220
[Close]
BLAST of FHA domain protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 70.8626 bits (172), Expect = 8.822e-14
Identity = 43/122 (35.25%), Postives = 64/122 (52.46%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP-------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EPS  +  T  + L + KG   L T  L   S    G+    C+I ++HPS+S+ HAV+Q R  D            YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRL-ASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFIL 220
[Close]
BLAST of FHA domain protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 70.8626 bits (172), Expect = 8.822e-14
Identity = 43/122 (35.25%), Postives = 64/122 (52.46%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP-------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EPS  +  T  + L + KG   L T  L   S    G+    C+I ++HPS+S+ HAV+Q R  D            YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRL-ASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFIL 220
[Close]
BLAST of FHA domain protein vs. Ensembl Mouse
Match: Slc4a1ap (solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608])

HSP 1 Score: 70.4774 bits (171), Expect = 1.017e-13
Identity = 43/122 (35.25%), Postives = 64/122 (52.46%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP-------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y EPS  +  T  + L + KG   L T  L   S    G+    C+I ++HPS+S+ HAV+Q R  D            YL DL ST+G+F++  +I P+ Y  +    V++FG STR ++L
Sbjct:  100 YREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRL-ASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFIL 220
[Close]
BLAST of FHA domain protein vs. UniProt/SwissProt
Match: sp|Q5M9G6|SNIP1_RAT (Smad nuclear interacting protein 1 OS=Rattus norvegicus OX=10116 GN=Snip1 PE=1 SV=1)

HSP 1 Score: 185.652 bits (470), Expect = 6.143e-56
Identity = 88/161 (54.66%), Postives = 118/161 (73.29%), Query Frame = 3 
Query:  144 PVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
            PVK E  +  L+G L E+TN ++GV I Y+EP EA  P  +WRLY FK DE LP +++HRQSAYL+G+HR I +IP+DHPS SKQHAV Q+R ++           V+PY+IDL S NG+F++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL + +  S+
Sbjct:  210 PVK-EKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSE 369
[Close]
BLAST of FHA domain protein vs. UniProt/SwissProt
Match: sp|Q8BIZ6|SNIP1_MOUSE (Smad nuclear-interacting protein 1 OS=Mus musculus OX=10090 GN=Snip1 PE=1 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 7.892e-56
Identity = 86/158 (54.43%), Postives = 116/158 (73.42%), Query Frame = 3 
Query:  153 KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
            KE  +  L+G L E+TN ++GV I Y+EP EA  P  +WRLY FK DE LP +++HRQSAYL+G+HR I +IP+DHPS SKQHAV Q+R ++           V+PY+IDL S NG+F++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL + +  S+
Sbjct:  208 KEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSE 365
[Close]
BLAST of FHA domain protein vs. UniProt/SwissProt
Match: sp|Q8TAD8|SNIP1_HUMAN (Smad nuclear-interacting protein 1 OS=Homo sapiens OX=9606 GN=SNIP1 PE=1 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 1.191e-55
Identity = 88/165 (53.33%), Postives = 119/165 (72.12%), Query Frame = 3 
Query:  132 KKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
            K+ E   KE  +  L+G L E+TN ++GV I Y+EP EA  P  +WRLY FK DE LP +++HRQSAYL+G+HR I +IP+DHPS SKQHAV Q+R ++           V+PY+IDL S NG+F++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL + +  S+
Sbjct:  214 KEKEVPAKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSE 378
[Close]
BLAST of FHA domain protein vs. UniProt/SwissProt
Match: sp|Q8W4D8|DDL_ARATH (FHA domain-containing protein DDL OS=Arabidopsis thaliana OX=3702 GN=DDL PE=1 SV=1)

HSP 1 Score: 166.007 bits (419), Expect = 3.740e-49
Identity = 81/152 (53.29%), Postives = 108/152 (71.05%), Query Frame = 3 
Query:  150 KKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESL-PTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDA---------GVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
            KKE  +  L+G LAEETN Y+G+ +++NEP EA  P+++WRLY FK  E L   + LHRQS YL G+ R I +IP DHPS SKQHAVIQ+R+++           V+PY++DL STN ++I+   IEPQ+YYEL E+D +KFG S+REYVLL
Sbjct:  157 KKEEPSFELSGKLAEETNRYRGITLLFNEPPEARKPSERWRLYVFKDGEPLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLL 308
[Close]
BLAST of FHA domain protein vs. UniProt/SwissProt
Match: sp|Q54VU4|Y8013_DICDI (Probable serine/threonine-protein kinase DDB_G0280133 OS=Dictyostelium discoideum OX=44689 GN=DDB_G0280133 PE=3 SV=1)

HSP 1 Score: 147.132 bits (370), Expect = 2.363e-39
Identity = 69/132 (52.27%), Postives = 94/132 (71.21%), Query Frame = 3 
Query:  216 VKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFR----------QIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTD 581
            +K+ ++EP+EA  PT+KW LY FKG + L TI+LHR+ ++L G++R I +IP+DHPS S QHAVI FR           I   + PY+IDL+STNG+F+ G KIEP KY+ELR +D + FG STREY+LL +
Sbjct: 1360 IKLKWHEPAEAKLPTEKWMLYPFKGKDQLDTIYLHRKKSFLFGRNRDIADIPIDHPSCSSQHAVIVFRIRKKENPNTGSIKTFILPYIIDLESTNGTFLKGEKIEPAKYFELRPKDKITFGTSTREYILLCE 1491
[Close]
BLAST of FHA domain protein vs. TrEMBL
Match: A0A016W0X2 (FHA domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0002.g678 PE=4 SV=1)

HSP 1 Score: 210.305 bits (534), Expect = 8.810e-64
Identity = 100/186 (53.76%), Postives = 135/186 (72.58%), Query Frame = 3 
Query:  132 KKMEPVK-KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID----AGVR-----PYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS*NIFLFFVNRFCYFQ 659
            K+ EPVK KE VN+ ++G LAE+TNM++GV I YNEP EA  PT +WRLY FKGDESLP +H+HRQSAYLIG+ R I ++P+DHPS SKQHAV+Q+R +      G R     PY+IDL S+NG+F++G KIEPQ+Y EL+E+DVLKFGFS+RE+V+L +K+   ++  D   +        C+ +
Sbjct:  119 KQEEPVKEKEKVNLEVSGKLAEDTNMFRGVLIKYNEPPEAKKPTLRWRLYPFKGDESLPVLHIHRQSAYLIGRDRKIADLPIDHPSCSKQHAVLQYRSVPFEKADGTRARRVLPYIIDLGSSNGTFLNGSKIEPQRYIELKEKDVLKFGFSSREFVVLNEKSAGDENASDPEPVVGLLQRMNCWLK 304
[Close]
BLAST of FHA domain protein vs. TrEMBL
Match: A0A016W2K9 (FHA domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0002.g678 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 2.901e-63
Identity = 99/170 (58.24%), Postives = 131/170 (77.06%), Query Frame = 3 
Query:  132 KKMEPVK-KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID----AGVR-----PYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEED 611
            K+ EPVK KE VN+ ++G LAE+TNM++GV I YNEP EA  PT +WRLY FKGDESLP +H+HRQSAYLIG+ R I ++P+DHPS SKQHAV+Q+R +      G R     PY+IDL S+NG+F++G KIEPQ+Y EL+E+DVLKFGFS+RE+V+L +K+   ++  D
Sbjct:  119 KQEEPVKEKEKVNLEVSGKLAEDTNMFRGVLIKYNEPPEAKKPTLRWRLYPFKGDESLPVLHIHRQSAYLIGRDRKIADLPIDHPSCSKQHAVLQYRSVPFEKADGTRARRVLPYIIDLGSSNGTFLNGSKIEPQRYIELKEKDVLKFGFSSREFVVLNEKSAGDENASD 288
[Close]
BLAST of FHA domain protein vs. TrEMBL
Match: A0A0D6LTY8 (FHA domain protein OS=Ancylostoma ceylanicum OX=53326 GN=ANCCEY_07381 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 3.005e-63
Identity = 99/170 (58.24%), Postives = 131/170 (77.06%), Query Frame = 3 
Query:  132 KKMEPVK-KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQI----DAGVR-----PYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEED 611
            K+ EPVK KE VN+ ++G LAE+TNM++GV I YNEP EA  PT +WRLY FKGDESLP +H+HRQSAYLIG+ R I ++P+DHPS SKQHAV+Q+R +      G R     PY+IDL S+NG+F++G KIEPQ+Y EL+E+DVLKFGFS+RE+V+L +K+   ++  D
Sbjct:   66 KQEEPVKEKEKVNLEVSGKLAEDTNMFRGVLIKYNEPPEAKKPTLRWRLYPFKGDESLPVLHIHRQSAYLIGRDRKIADLPIDHPSCSKQHAVLQYRSVPFEKADGTRARRVLPYIIDLGSSNGTFLNGSKIEPQRYIELKEKDVLKFGFSSREFVVLNEKSAGDENASD 235
[Close]
BLAST of FHA domain protein vs. TrEMBL
Match: A0A016W0Q3 (FHA domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0002.g678 PE=4 SV=1)

HSP 1 Score: 207.608 bits (527), Expect = 9.042e-63
Identity = 99/170 (58.24%), Postives = 131/170 (77.06%), Query Frame = 3 
Query:  132 KKMEPVK-KEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID----AGVR-----PYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEED 611
            K+ EPVK KE VN+ ++G LAE+TNM++GV I YNEP EA  PT +WRLY FKGDESLP +H+HRQSAYLIG+ R I ++P+DHPS SKQHAV+Q+R +      G R     PY+IDL S+NG+F++G KIEPQ+Y EL+E+DVLKFGFS+RE+V+L +K+   ++  D
Sbjct:  119 KQEEPVKEKEKVNLEVSGKLAEDTNMFRGVLIKYNEPPEAKKPTLRWRLYPFKGDESLPVLHIHRQSAYLIGRDRKIADLPIDHPSCSKQHAVLQYRSVPFEKADGTRARRVLPYIIDLGSSNGTFLNGSKIEPQRYIELKEKDVLKFGFSSREFVVLNEKSAGDENASD 288
[Close]
BLAST of FHA domain protein vs. TrEMBL
Match: A0A183FSI1 (FHA domain-containing protein OS=Heligmosomoides polygyrus OX=6339 GN=HPBE_LOCUS10906 PE=4 SV=1)

HSP 1 Score: 203.756 bits (517), Expect = 9.389e-63
Identity = 104/205 (50.73%), Postives = 141/205 (68.78%), Query Frame = 3 
Query:   15 QIFKMPFNEG-HRHRSKTKSKSYSPRSFKKSDHSHHNDKYKKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQI-----DAG----VRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASD 599
            ++ K P  EG  + RS + +K+Y     KK D          +   +KE VN+ ++G LAE+TNMYKGV I YNEP EA  PT +WRLY FKGDE+LP +H+HRQSAYLIG+ R I ++P+DHPS SKQHAV+Q+R +     D      V PY+IDL S+NG+ ++G KIEPQ+Y EL+E+DVLKFGFS+RE+V+L +K+   +
Sbjct:    9 EVKKEPDEEGPSKRRSDSSAKNYGLEKKKKED----------VPAKEKEKVNLGVSGKLAEDTNMYKGVLIKYNEPPEAKKPTIRWRLYPFKGDEALPVLHIHRQSAYLIGRDRKIADLPIDHPSCSKQHAVLQYRSVPFERADGTKARRVLPYIIDLGSSNGTLLNGAKIEPQRYVELKEKDVLKFGFSSREFVVLNEKSAGEE 203
[Close]
BLAST of FHA domain protein vs. Ensembl Cavefish
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:103022573])

HSP 1 Score: 182.956 bits (463), Expect = 3.603e-56
Identity = 85/152 (55.92%), Postives = 112/152 (73.68%), Query Frame = 3 
Query:  147 VKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
            V+KE  N  L+G L E+TN ++GV I YNEP EA  P  +WRLY FK DE LP +++HRQSAYL+G+ R I +IP+DHPS SKQHAV Q+R ++           V+PY+IDL S NG++++  +IE Q+YYEL+E+DVLKFGFS+REYVLL
Sbjct:  182 VEKEKPNFELSGALVEDTNTFRGVVIKYNEPPEARIPKRRWRLYPFKNDEPLPVMYIHRQSAYLLGRQRKIADIPIDHPSCSKQHAVFQYRLVEHKRADGTTGRRVKPYIIDLGSGNGTYLNNQRIESQRYYELKEKDVLKFGFSSREYVLL 333
[Close]
BLAST of FHA domain protein vs. Ensembl Cavefish
Match: slc4a1ap (solute carrier family 4 member 1 adaptor protein [Source:ZFIN;Acc:ZDB-GENE-080521-2])

HSP 1 Score: 84.7297 bits (208), Expect = 1.203e-18
Identity = 51/131 (38.93%), Postives = 81/131 (61.83%), Query Frame = 3 
Query:  222 IIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS 614
            + Y+EP  A   T  +     K    L +I L +QS +++G+   +C++ ++HPSIS+ HAV+Q+R+ +AG   Y+ DL ST+G+F++  KI P+ Y  LR   VLKFG STR ++L   +   SD+E +S
Sbjct:  167 LPYSEPPWAGVATVPYSFELLKNGAILDSIPLTQQSYFVVGRLP-VCDVSLEHPSISRYHAVVQYRE-EAGF--YVYDLGSTHGTFLNKNKIPPKTYIRLRVGHVLKFGGSTRLFIL---QGPESDEEAES 290
[Close]
BLAST of FHA domain protein vs. Ensembl Cavefish
Match: ppp1r8b (protein phosphatase 1, regulatory subunit 8b [Source:ZFIN;Acc:ZDB-GENE-040426-1271])

HSP 1 Score: 67.3958 bits (163), Expect = 5.264e-13
Identity = 37/115 (32.17%), Postives = 63/115 (54.78%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            ++ PS A  P     L   KGD+ +  + +  +  YL G++  +C+  +DH S S+ HA + + +     R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y +
Sbjct:   12 FDCPSWAGKPPPGLHLDVVKGDKLVEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHK--HLKRLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTI 124
[Close]
BLAST of FHA domain protein vs. Ensembl Cavefish
Match: ppp1r8a (nuclear inhibitor of protein phosphatase 1-like [Source:NCBI gene;Acc:103022114])

HSP 1 Score: 65.4698 bits (158), Expect = 2.809e-12
Identity = 38/116 (32.76%), Postives = 63/116 (54.31%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQF-RQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            ++ P+ A  P     L   KGD+ +  + +  +  YL G++   C+  +DH S S+ HA + + R +    R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y L
Sbjct:   10 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKFYLFGRNPDHCDFTIDHQSCSRVHAALVYHRHLK---RVFLIDLNSTHGTFLGRIRLEPHKPQQVPIDSTMSFGASTRVYTL 122
[Close]
BLAST of FHA domain protein vs. Ensembl Cavefish
Match: ppp1r8a (nuclear inhibitor of protein phosphatase 1-like [Source:NCBI gene;Acc:103022114])

HSP 1 Score: 65.0846 bits (157), Expect = 3.731e-12
Identity = 39/125 (31.20%), Postives = 65/125 (52.00%), Query Frame = 3 
Query:  201 NMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQF-RQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            N+  G+ +  +    A  P     L   KGD+ +  + +  +  YL G++   C+  +DH S S+ HA + + R +    R +LIDL ST+G+F+  I++EP K  ++     + FG STR Y L
Sbjct:   11 NLNGGLALPQDHGPVAGKPPPGLHLDVVKGDKLIEKLIIDEKKFYLFGRNPDHCDFTIDHQSCSRVHAALVYHRHLK---RVFLIDLNSTHGTFLGRIRLEPHKPQQVPIDSTMSFGASTRVYTL 132
[Close]
BLAST of FHA domain protein vs. Ensembl Sea Lamprey
Match: cep170aa (centrosomal protein 170Aa [Source:NCBI gene;Acc:557463])

HSP 1 Score: 53.1434 bits (126), Expect = 1.576e-8
Identity = 29/85 (34.12%), Postives = 46/85 (54.12%), Query Frame = 3 
Query:  318 HRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            HR    LI   R  CE+ +   S+ KQHAVI +  +    +  L DL S NG+F++ + +  Q Y  L++ DV++FG+    Y +
Sbjct:   16 HRLPRELIFAGREDCELVLHSRSVDKQHAVINYDLVHD--QHMLKDLGSLNGTFVNEVPVPDQTYVSLKQSDVIRFGYDPNVYTV 98
[Close]
BLAST of FHA domain protein vs. Ensembl Sea Lamprey
Match: cep170aa (centrosomal protein 170Aa [Source:NCBI gene;Acc:557463])

HSP 1 Score: 53.1434 bits (126), Expect = 1.597e-8
Identity = 29/85 (34.12%), Postives = 46/85 (54.12%), Query Frame = 3 
Query:  318 HRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            HR    LI   R  CE+ +   S+ KQHAVI +  +    +  L DL S NG+F++ + +  Q Y  L++ DV++FG+    Y +
Sbjct:   16 HRLPRELIFAGREDCELVLHSRSVDKQHAVINYDLVHD--QHMLKDLGSLNGTFVNEVPVPDQTYVSLKQSDVIRFGYDPNVYTV 98
[Close]
BLAST of FHA domain protein vs. Ensembl Sea Lamprey
Match: cep170aa (centrosomal protein 170Aa [Source:NCBI gene;Acc:557463])

HSP 1 Score: 52.7582 bits (125), Expect = 1.686e-8
Identity = 29/85 (34.12%), Postives = 46/85 (54.12%), Query Frame = 3 
Query:  318 HRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            HR    LI   R  CE+ +   S+ KQHAVI +  +    +  L DL S NG+F++ + +  Q Y  L++ DV++FG+    Y +
Sbjct:   16 HRLPRELIFAGREDCELVLHSRSVDKQHAVINYDLVHD--QHMLKDLGSLNGTFVNEVPVPDQTYVSLKQSDVIRFGYDPNVYTV 98
[Close]
BLAST of FHA domain protein vs. Ensembl Sea Lamprey
Match: si:ch73-212j7.1 (centrosomal protein 170B [Source:ZFIN;Acc:ZDB-GENE-131127-515])

HSP 1 Score: 45.0542 bits (105), Expect = 8.013e-6
Identity = 26/87 (29.89%), Postives = 45/87 (51.72%), Query Frame = 3 
Query:  318 HRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPY-LIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
            HR    +I   R  CE+ +   S+ +QHAV+ +   D     + ++DL S NG+F++  +I    Y  L+  D ++FG+  R +  L
Sbjct:   16 HRLPKEMIFVGRDECELMLQSRSVDRQHAVVNY---DPATDEHKVMDLGSLNGTFVNESRIPEHTYLILKLNDTIRFGYDIRSHPNL 99
[Close]
BLAST of FHA domain protein vs. Ensembl Yeast
Match: PML1 (Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p [Source:SGD;Acc:S000004006])

HSP 1 Score: 66.6254 bits (161), Expect = 4.362e-14
Identity = 41/154 (26.62%), Postives = 75/154 (48.70%), Query Frame = 3 
Query:  177 TGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKG-DESLPTIHLHR----------------QSAYLIGKHRG--------------ICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKF 545
            +GLL  E+N  +G+ + + EP +A +P +   +   +  D ++  + ++R                +S YL+G+  G              + +I +   + SKQH VIQFR +   ++ Y++DL S+NG+ ++ + I   +Y ELR  DVL  
Sbjct:   35 SGLLELESNNKEGIALKHVEPQDAISPDNYMDMLGLEARDRTMYELVIYRKNDKDKGPWKRYDLNGRSCYLVGRELGHSLDTDLDDRTEIVVADIGIPEETSSKQHCVIQFRNVRGILKCYVMDLDSSNGTCLNNVVIPGARYIELRSGDVLTL 188
[Close]
BLAST of FHA domain protein vs. Ensembl Nematostella
Match: EDO38224 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDH1])

HSP 1 Score: 185.267 bits (469), Expect = 6.818e-60
Identity = 85/150 (56.67%), Postives = 114/150 (76.00%), Query Frame = 3 
Query:  165 NMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKA 587
            N  L+G L E TN YKGV I YNEP EA  P  +WRLY FKG+ESLP +++HRQSAYL+G+ R I +IP+DHPS SKQHA++Q+R ++           V+PY++DL S NG+F++  K+EP++YYEL+E+DVLKFGFS+REYVLL +K+
Sbjct:   17 NYELSGKLTEYTNTYKGVVIKYNEPPEARKPNTRWRLYPFKGEESLPVMYIHRQSAYLLGRQRHIADIPIDHPSCSKQHAILQYRLVNYEKPDGSKGRRVKPYVLDLDSANGTFLNNQKVEPRRYYELKERDVLKFGFSSREYVLLHEKS 166
[Close]
BLAST of FHA domain protein vs. Ensembl Nematostella
Match: EDO47533 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM34])

HSP 1 Score: 71.633 bits (174), Expect = 9.380e-15
Identity = 40/116 (34.48%), Postives = 66/116 (56.90%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQF-RQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            Y  PS A  PT    L   K D+ +  + +  +  YL G+++ +C+  ++H S S+ HA + F R +    R +L+DL ST+G++I  I+IE  K  +++   V++FG STR Y L
Sbjct:   27 YQVPSWAGKPTQGLHLDVMKMDKLVEKLIIDGKPCYLFGRNKDVCDFMVEHSSCSRVHAALVFHRHLK---RCFLVDLGSTHGTYIGTIRIERNKPTQVQVDSVIRFGASTRTYTL 139
[Close]
BLAST of FHA domain protein vs. Ensembl Nematostella
Match: EDO32995 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STE9])

HSP 1 Score: 71.2478 bits (173), Expect = 1.906e-14
Identity = 38/96 (39.58%), Postives = 62/96 (64.58%), Query Frame = 3 
Query:  300 LPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFR-----QIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            + T+ L  +  YL G+    C++ M+HPS+S+ HA+IQ++     + D G   YL DL ST+G+ ++ + I+P+KYY LR   V+KFG S+R ++L
Sbjct:   81 ISTLDLTSKPYYLFGRLPN-CDVVMEHPSVSRYHAIIQYKAGQTSKSDQGF--YLYDLGSTHGTMVNKVPIDPKKYYRLRVGYVIKFGGSSRLFIL 173
[Close]
BLAST of FHA domain protein vs. Ensembl Medaka
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:101173889])

HSP 1 Score: 193.741 bits (491), Expect = 2.000e-60
Identity = 89/165 (53.94%), Postives = 114/165 (69.09%), Query Frame = 3 
Query:  108 HSHHNDKYKKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
             S   D      P +KE  N  L+G L E+TN ++GV I YNEP EA  P  +WRLY FK DE LP +++HRQSAYL+G+ R I +IP+DHPS SKQHAV Q+R +            VRPY+IDL S NG++++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL
Sbjct:  168 QSEEGDNSSSAPPAEKEKPNFELSGALTEDTNTFRGVVIKYNEPPEARIPKRRWRLYPFKNDEPLPVMYVHRQSAYLLGRQRKIADIPIDHPSCSKQHAVFQYRLVQYTRADGTTGRRVRPYIIDLASGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVLL 332
[Close]
BLAST of FHA domain protein vs. Ensembl Medaka
Match: SNIP1 (Smad nuclear interacting protein 1 [Source:NCBI gene;Acc:101173889])

HSP 1 Score: 193.741 bits (491), Expect = 2.060e-60
Identity = 89/165 (53.94%), Postives = 114/165 (69.09%), Query Frame = 3 
Query:  108 HSHHNDKYKKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQID---------AGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLL 575
             S   D      P +KE  N  L+G L E+TN ++GV I YNEP EA  P  +WRLY FK DE LP +++HRQSAYL+G+ R I +IP+DHPS SKQHAV Q+R +            VRPY+IDL S NG++++  +IEPQ+YYEL+E+DVLKFGFS+REYVLL
Sbjct:  168 QSEEGDNSSSAPPAEKEKPNFELSGALTEDTNTFRGVVIKYNEPPEARIPKRRWRLYPFKNDEPLPVMYVHRQSAYLLGRQRKIADIPIDHPSCSKQHAVFQYRLVQYTRADGTTGRRVRPYIIDLASGNGTYLNNQRIEPQRYYELKEKDVLKFGFSSREYVLL 332
[Close]
BLAST of FHA domain protein vs. Ensembl Medaka
Match: slc4a1ap (solute carrier family 4 member 1 adaptor protein [Source:NCBI gene;Acc:101169402])

HSP 1 Score: 75.8702 bits (185), Expect = 1.206e-15
Identity = 48/126 (38.10%), Postives = 72/126 (57.14%), Query Frame = 3 
Query:  222 IIYNEPSEAATPTD-KWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP--------YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            I Y EP    +P+D ++ L   K    + T+ L   S +++G+   +C++ ++HPSIS+ HAVIQ+R   AG           Y+ DL ST+G+ ++  KI P+ Y  LR   VLKFG STR +VL
Sbjct:  139 IPYTEPLWGGSPSDAQYALEILKNGAIVDTVPLSHSSFFVVGRLP-VCDVSLEHPSISRYHAVIQYRS-QAGQEGCVGEERGFYIHDLGSTHGTVVNKNKIPPKTYIRLRVGHVLKFGGSTRLFVL 262
[Close]
BLAST of FHA domain protein vs. Ensembl Medaka
Match: ppp1r8b (protein phosphatase 1 regulatory subunit 8 [Source:NCBI gene;Acc:111948964])

HSP 1 Score: 64.6994 bits (156), Expect = 6.149e-12
Identity = 37/115 (32.17%), Postives = 62/115 (53.91%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            ++ PS A  P     L   KGD+ +  + +  +  YL G++   C+  +DH S S+ HA + + +     R +LIDL ST+G+F+  I++E  K  ++     L FG STR Y++
Sbjct:   13 FDCPSWAGKPPTGLHLDVMKGDKLIEKLIIDEKKFYLFGRNPDWCDFTIDHQSCSRVHAALVYHK--HLKRLFLIDLNSTHGTFLGHIRLEAHKPQQVPIDSTLAFGASTRTYII 125
[Close]
BLAST of FHA domain protein vs. Ensembl Medaka
Match: ppp1r8b (protein phosphatase 1 regulatory subunit 8 [Source:NCBI gene;Acc:111948964])

HSP 1 Score: 64.3142 bits (155), Expect = 8.373e-12
Identity = 37/115 (32.17%), Postives = 62/115 (53.91%), Query Frame = 3 
Query:  228 YNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            ++ PS A  P     L   KGD+ +  + +  +  YL G++   C+  +DH S S+ HA + + +     R +LIDL ST+G+F+  I++E  K  ++     L FG STR Y++
Sbjct:   13 FDCPSWAGKPPTGLHLDVMKGDKLIEKLIIDEKKFYLFGRNPDWCDFTIDHQSCSRVHAALVYHK--HLKRLFLIDLNSTHGTFLGHIRLEAHKPQQVPIDSTLAFGASTRTYII 125
[Close]
BLAST of FHA domain protein vs. Planmine SMEST
Match: SMESG000021239.1 (SMESG000021239.1)

HSP 1 Score: 405.216 bits (1040), Expect = 3.667e-146
Identity = 194/196 (98.98%), Postives = 195/196 (99.49%), Query Frame = 3 
Query:   27 MPFNEGHRHRSKTKSKSYSPRSFKKSDHSHHNDKYKKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS 614
            MPFNEGHRHRSKTKSKSYSPRSFKKSDH HHNDKYKKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQ+DAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS
Sbjct:    1 MPFNEGHRHRSKTKSKSYSPRSFKKSDHLHHNDKYKKMEPVKKEFVNMRLTGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQLDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS 196
[Close]
BLAST of FHA domain protein vs. Planmine SMEST
Match: SMESG000074111.1 (SMESG000074111.1)

HSP 1 Score: 64.3142 bits (155), Expect = 6.622e-12
Identity = 39/130 (30.00%), Postives = 69/130 (53.08%), Query Frame = 3 
Query:  198 TNMYKGVKIIYNEPSEAATPTD-KWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRP----YLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            TN    +   Y EP  +    D ++ L   K    +  I L+ +  Y++G+++  C++  DHPS+S+ H+V+Q+   D   +     YL+DL ST+G+ ++  KI    +  +    V+KFG STR Y++
Sbjct:    5 TNHNDEINCCYKEPKWSGICNDHEYGLDVLKNGVIIENIKLNEKPYYIVGRYK-TCDLIFDHPSLSRFHSVLQYCSSDNEEKKEKGWYLMDLDSTHGTIVNKKKIPSHTFIRVHTGHVIKFGGSTRLYIV 133
[Close]
BLAST of FHA domain protein vs. Planmine SMEST
Match: SMESG000055731.1 (SMESG000055731.1)

HSP 1 Score: 63.5438 bits (153), Expect = 1.172e-11
Identity = 39/125 (31.20%), Postives = 64/125 (51.20%), Query Frame = 3 
Query:  201 NMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQSAYLIGKHRGICEIPMDHPSISKQH-AVIQFRQIDAGVRPYLIDLKSTNGSFISGIKIEPQKYYELREQDVLKFGFSTREYVL 572
            N+    KI    P  A  P     L   K  + +  + +  +  Y  G++R +C+ P+DH S S+ H A++  + +    RP+LIDL S +G+FI  I++E  K  ++     + FG STR YV+
Sbjct:   12 NLTNNFKI----PDWAGKPPPGLHLDVMKDGKLIQKLMIDEKRCYFFGRNRQLCDFPIDHQSGSRVHGALVWHKDLH---RPFLIDLSSVHGTFIGSIRLEGGKPQQIPIDSKIHFGASTRMYVI 129
The following BLAST results are available for this feature:
BLAST of FHA domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SNIP12.480e-5653.33Smad nuclear interacting protein 1 [Source:HGNC Sy... [more]
SLC4A1AP2.266e-1336.07solute carrier family 4 member 1 adaptor protein [... [more]
SLC4A1AP2.392e-1336.07solute carrier family 4 member 1 adaptor protein [... [more]
SLC4A1AP2.392e-1336.07solute carrier family 4 member 1 adaptor protein [... [more]
PPP1R85.116e-1331.90protein phosphatase 1 regulatory subunit 8 [Source... [more]
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BLAST of FHA domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
C32E8.52.395e-5753.89pep chromosome:WBcel235:I:3782118:3783232:1 gene:W... [more]
C32E8.52.395e-5753.89pep chromosome:WBcel235:I:3782118:3783294:1 gene:W... [more]
B0511.74.337e-725.19pep chromosome:WBcel235:I:10631665:10633150:-1 gen... [more]
ZK632.21.052e-632.05pep chromosome:WBcel235:III:9799107:9802333:1 gene... [more]
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BLAST of FHA domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CG171681.297e-5149.09gene:FBgn0039943 transcript:FBtr0113730[more]
NiPp12.715e-1131.03gene:FBgn0026402 transcript:FBtr0087058[more]
CG77064.101e-827.97gene:FBgn0038640 transcript:FBtr0083667[more]
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BLAST of FHA domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
snip17.007e-5756.58Smad nuclear interacting protein [Source:ZFIN;Acc:... [more]
snip12.669e-5656.58Smad nuclear interacting protein [Source:ZFIN;Acc:... [more]
slc4a1ap2.742e-1537.90solute carrier family 4 member 1 adaptor protein [... [more]
ppp1r8b1.934e-1333.62protein phosphatase 1, regulatory subunit 8b [Sour... [more]
ppp1r8b1.972e-1333.62protein phosphatase 1, regulatory subunit 8b [Sour... [more]
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BLAST of FHA domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
snip13.349e-5854.38Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
alkbh73.014e-1434.31alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693][more]
alkbh71.327e-1334.31alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693][more]
ak61.408e-1333.90adenylate kinase 6 [Source:Xenbase;Acc:XB-GENE-972... [more]
alkbh72.338e-1334.31alkB homolog 7 [Source:Xenbase;Acc:XB-GENE-958693][more]
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BLAST of FHA domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Snip11.128e-5654.43Smad nuclear interacting protein 1 [Source:MGI Sym... [more]
Slc4a1ap7.134e-1435.25solute carrier family 4 (anion exchanger), member ... [more]
Slc4a1ap8.822e-1435.25solute carrier family 4 (anion exchanger), member ... [more]
Slc4a1ap8.822e-1435.25solute carrier family 4 (anion exchanger), member ... [more]
Slc4a1ap1.017e-1335.25solute carrier family 4 (anion exchanger), member ... [more]
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BLAST of FHA domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5M9G6|SNIP1_RAT6.143e-5654.66Smad nuclear interacting protein 1 OS=Rattus norve... [more]
sp|Q8BIZ6|SNIP1_MOUSE7.892e-5654.43Smad nuclear-interacting protein 1 OS=Mus musculus... [more]
sp|Q8TAD8|SNIP1_HUMAN1.191e-5553.33Smad nuclear-interacting protein 1 OS=Homo sapiens... [more]
sp|Q8W4D8|DDL_ARATH3.740e-4953.29FHA domain-containing protein DDL OS=Arabidopsis t... [more]
sp|Q54VU4|Y8013_DICDI2.363e-3952.27Probable serine/threonine-protein kinase DDB_G0280... [more]
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BLAST of FHA domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A016W0X28.810e-6453.76FHA domain-containing protein OS=Ancylostoma ceyla... [more]
A0A016W2K92.901e-6358.24FHA domain-containing protein OS=Ancylostoma ceyla... [more]
A0A0D6LTY83.005e-6358.24FHA domain protein OS=Ancylostoma ceylanicum OX=53... [more]
A0A016W0Q39.042e-6358.24FHA domain-containing protein OS=Ancylostoma ceyla... [more]
A0A183FSI19.389e-6350.73FHA domain-containing protein OS=Heligmosomoides p... [more]
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BLAST of FHA domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SNIP13.603e-5655.92Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
slc4a1ap1.203e-1838.93solute carrier family 4 member 1 adaptor protein [... [more]
ppp1r8b5.264e-1332.17protein phosphatase 1, regulatory subunit 8b [Sour... [more]
ppp1r8a2.809e-1232.76nuclear inhibitor of protein phosphatase 1-like [S... [more]
ppp1r8a3.731e-1231.20nuclear inhibitor of protein phosphatase 1-like [S... [more]
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BLAST of FHA domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cep170aa1.576e-834.12centrosomal protein 170Aa [Source:NCBI gene;Acc:55... [more]
cep170aa1.597e-834.12centrosomal protein 170Aa [Source:NCBI gene;Acc:55... [more]
cep170aa1.686e-834.12centrosomal protein 170Aa [Source:NCBI gene;Acc:55... [more]
si:ch73-212j7.18.013e-629.89centrosomal protein 170B [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of FHA domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
PML14.362e-1426.62Subunit of the RES complex; RES complex is require... [more]
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BLAST of FHA domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO382246.818e-6056.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO475339.380e-1534.48Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO329951.906e-1439.58Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of FHA domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SNIP12.000e-6053.94Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
SNIP12.060e-6053.94Smad nuclear interacting protein 1 [Source:NCBI ge... [more]
slc4a1ap1.206e-1538.10solute carrier family 4 member 1 adaptor protein [... [more]
ppp1r8b6.149e-1232.17protein phosphatase 1 regulatory subunit 8 [Source... [more]
ppp1r8b8.373e-1232.17protein phosphatase 1 regulatory subunit 8 [Source... [more]
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BLAST of FHA domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000021239.13.667e-14698.98SMESG000021239.1[more]
SMESG000074111.16.622e-1230.00SMESG000074111.1[more]
SMESG000055731.11.172e-1131.20SMESG000055731.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30027005 ID=SMED30027005|Name=FHA domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=659bp
CGATCTATTTTTGACAAATTTTTAAAATGCCCTTTAATGAAGGTCATCGT
CATCGATCAAAAACAAAGTCGAAATCATATTCCCCTCGTTCATTCAAAAA
GTCTGATCATTCACATCATAATGATAAATATAAAAAGATGGAACCAGTTA
AGAAAGAATTTGTGAATATGCGGCTTACGGGATTATTAGCAGAAGAAACT
AATATGTATAAAGGAGTTAAAATAATATACAATGAACCATCTGAAGCTGC
TACTCCAACTGATAAATGGCGGTTGTATTCTTTTAAAGGAGACGAATCCT
TGCCAACAATTCACCTTCACCGCCAGAGTGCTTATTTGATTGGAAAACAC
AGGGGTATTTGCGAAATCCCAATGGATCATCCTAGCATCAGTAAACAACA
TGCTGTTATTCAGTTCAGACAAATAGATGCCGGCGTTAGACCGTATTTAA
TTGACTTGAAGTCAACAAACGGCTCGTTTATAAGTGGAATAAAAATTGAG
CCTCAGAAATATTACGAATTAAGAGAACAGGATGTTTTGAAATTCGGATT
CTCTACTCGAGAGTACGTTTTGTTGACAGATAAAGCACTCGCTTCGGATG
ACGAGGAGGATTCTTGAAATATTTTTTTATTTTTTGTAAATAGATTTTGT
TATTTTCAA
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protein sequence of SMED30027005-orf-1

>SMED30027005-orf-1 ID=SMED30027005-orf-1|Name=SMED30027005-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=197bp
MPFNEGHRHRSKTKSKSYSPRSFKKSDHSHHNDKYKKMEPVKKEFVNMRL
TGLLAEETNMYKGVKIIYNEPSEAATPTDKWRLYSFKGDESLPTIHLHRQ
SAYLIGKHRGICEIPMDHPSISKQHAVIQFRQIDAGVRPYLIDLKSTNGS
FISGIKIEPQKYYELREQDVLKFGFSTREYVLLTDKALASDDEEDS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR000253FHA_dom
IPR008984SMAD_FHA_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0003723RNA binding
GO:0003729mRNA binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005829cytosol
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
GO:0007249I-kappaB kinase/NF-kappaB signaling
GO:0031047gene silencing by RNA
GO:0035196production of miRNAs involved in gene silencing by miRNA
GO:1903955positive regulation of protein targeting to mitochondrion
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000253Forkhead-associated (FHA) domainSMARTSM00240FHA_2coord: 102..157
e-value: 3.0E-11
score: 53.4
IPR000253Forkhead-associated (FHA) domainPFAMPF00498FHAcoord: 103..174
e-value: 1.4E-16
score: 60.6
IPR000253Forkhead-associated (FHA) domainPROSITEPS50006FHA_DOMAINcoord: 103..157
score: 13.077
IPR000253Forkhead-associated (FHA) domainCDDcd00060FHAcoord: 80..174
e-value: 2.07367E-26
score: 95.1458
NoneNo IPR availableGENE3DG3DSA:2.60.200.20coord: 29..184
e-value: 3.1E-49
score: 169.0
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..36
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 20..36
NoneNo IPR availablePANTHERPTHR23308NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1coord: 15..190
NoneNo IPR availablePANTHERPTHR23308:SF36SMAD NUCLEAR-INTERACTING PROTEIN 1coord: 15..190
IPR008984SMAD/FHA domain superfamilySUPERFAMILYSSF49879SMAD/FHA domaincoord: 75..182