cilia- and flagella-associated protein 251

Query:  571 QDKN-PVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSD------KKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQ 3285
            +DK+ PV  LT  +S G+N  +P+  +  + +  + Y C+H  IIY+ + N Q  LQGH N ISC   S+D+RW+ T D+G + +VIIWD  TG+PV T+F+  P  NG++A+++T DA+YLAT+S    Q   IW WT   + P C+  L T YG+QNY++FN  +  ++ +NS+T+ ++Y W ++   L + AP LT++ FNK +GKF  ++F    T+ LSAT +G LVVW+     I  P  S S        K  KLV +  + ITVLT   S+IVTGD+ G+IKF+D+   ++ WY     G I ++S S + +        E S+YP D T++ + F + +FI+GT+ A    +T  G+K++ +F +   ++ ++  HP  PL+A GS  G++K+WNYE ++ + +R+F K + ++SL ++  G  +  GF  G + ILD  +L++   +PF +S+  +THI FS  S+++AT D +FT  +Y     N +  W Y+AR R+H K I  LLFG Y D+  PRL +LG DR L+EYDL  + +D L +L     +Q   P    WYP    E F++  N  YK+K++N  TKMCR + LGP +GSP++  + LP+    RS+ + +++RYL + NR+K+GL  +P++GNP+    ++ HP GV  +  S+DG Y  +  G D  V  WKI L +LEA   LGG+ +TP+Y L+ GG  G F  EL++YFYYS +R+QGID+++ R V   I +SE+P++MRAIGFYPSEE+I+++ NE+KF +Y +TGK  DK++L  F+KVY+NH+P FG +   I ++F  +   +++G+ +I +  FL LL+ KGE + E ++ +  A+L G N EG   E    +       + E LP  +T + F   I+ + I +   Q
Sbjct:  240 KDKSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHLNLTQILSATMEGKLVVWD-----IHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPT----EKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSNEPRLLSLGTDRLLIEYDLLRSYKDHLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEQTQVLPV----RSMAE-LQKRYLVFINRDKVGLQILPVDGNPHKTSAIVCHPNGVAGMAVSYDGCYAFTAGGHDRSVVQWKITLSVLEAAVSLGGEDLTPFYGLLSGGREGKFYRELEDYFYYSQLRSQGIDTMETRKVSEHICLSELPFVMRAIGFYPSEEKIDDIFNEIKFGEYVDTGKLIDKINLPDFLKVYLNHKPPFGNTMSGIHKSFEVLGYTNSKGKKAIRREDFLRLLVTKGEHMTEEEMLDCFASLFGLNPEGWKSEPATCSVKGSEICLEEELPDEITAEIFATEILGLTISEDSGQ 1146          

Query:  571 QDKN-PVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSD------KKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINL 2628
            +DK+ PV  LT  +S G+N  +P+  +  + +  + Y C+H  IIY+ + N Q  LQGH N ISC   S+D+RW+ T D+G + +VIIWD  TG+PV T+F+  P  NG++A+++T DA+YLAT+S    Q   IW WT   + P C+  L T YG+QNY++FN  +  ++ +NS+T+ ++Y W ++   L + AP LT++ FNK +GKF  ++F    T+ LSAT +G LVVW+     I  P  S S        K  KLV +  + ITVLT   S+IVTGD+ G+IKF+D+   ++ WY     G I ++S S + +        E S+YP D T++ + F + +FI+GT+ A    +T  G+K++ +F +   ++ ++  HP  PL+A GS  G++K+WNYE ++ + +R+F K + ++SL ++  G  +  GF  G + ILD  +L++   +PF +S+  +THI FS  S+++AT D +FT  +Y     N +  W Y+AR R+H K I  LLFG Y D+  PRL +LG DR L+EYDL  + +D L +L     +Q   P    WYP    E F++  N  YK+K++N  TKMCR + LGP +GSP++  + LP+    RS+ + +++RYL + NR+K+GL  +P++GNP+    ++ HP GV  +  S+DG Y  +  G D  V  WKI L
Sbjct:  240 KDKSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHLNLTQILSATMEGKLVVWD-----IHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPT----EKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSNEPRLLSLGTDRLLIEYDLLRSYKDHLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEQTQVLPV----RSMAE-LQKRYLVFINRDKVGLQILPVDGNPHKTSAIVCHPNGVAGMAVSYDGCYAFTAGGHDRSVVQWKITL 923          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYI---SFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTR----ALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATV 1980
            PQ      +    +P + ++K P  +L   +  G+  Y    NL       + Y  + + ++Y+   + Q +  GH + I   T    K ++ TG  G ++ + +WD  T   +  +   H  GV A+  + D + L ++  ++  +   WDW  GE +       +T  G ++ I     N   + ++ T     + F+Q    G    F  K   +     +GK   T+      R      S  + G + +W+              D   +K V  HD  +  +       VTG   G ++ +D  +              +     ++ S      +LE+     + +I++        +VGT       +   G    ++    +  V+ + AHP LP+ AT S    L+IW    +  +      K   +   F   G  +AVG  +G   +++   ++D++S  FH  K  I+ I+FS+ + ++LA  
Sbjct:  651 PQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKI-------ATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGG----FTSK---RGTFGSVGKL-ETMMCVSYGRMEDLVFSGAATGDIFIWK--------------DILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCL---------KTYAIKRSALSTSSKGLLLED-----NPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVS--FHHRKEMISDIKFSKDTGKYLAVA 1101          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL--PKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            + Y  + +G++Y+   + Q    GH + I       DK  + TG  G+   + IWD      V  + + H +GV  ++   D + LA++  +   T  IWDW  G+   L SA+  ++      IS++     +V +     + F  W   GN    A       F K  G     L L   K     S    G + VW+G ++L++             +   H   I  +        TG   G I+ +D            +F P           + KI        Y +  +I+S  +     + GT  + IF  +  +  K  +I + H +  ++++  HP  PL  TGS    +++W+      I  R   +  ++S+ F   G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA
Sbjct:   36 VVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGK--LLASATGHSDRIFD--ISWDPYQPNRVVSCGVKHIKF--WTLCGN----ALTAKRGIFGK-TGDLQTILCLACAKEDITYSGALNGDIYVWKG-LNLVRT------------IQGAHSAGIFSMYACEEGFATGGRDGCIRLWDT-----------DFKP-----------ITKIDLRETEQGY-KGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI-ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIH--EMKFSPDGSYLA 424          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYI---SFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTR----ALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATV 1980
            PQ      +    +P + ++K P  +L   +  G+  Y    NL       + Y  + + ++Y+   + Q +  GH + I   T    K ++ TG  G ++ + +WD  T   +  +   H  GV A+  + D + L ++  ++  +   WDW  GE +       +T  G ++ I     N   + ++ T     + F+Q    G    F  K   +     +GK   T+      R      S  + G + +W+              D   +K V  HD  +  +       VTG   G ++ +D   M     + +     +  +SS    LE            ++ +I++        +VGT       +   G    ++    +  V+ + AHP LP+ AT S    L+IW    +  +      K   +   F   G  +AVG  +G   +++   ++D++S  FH  K  I+ I+FS+ + ++LA  
Sbjct:  651 PQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKI-------ATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGG----FTSK---RGTFGSVGKL-ETMMCVSYGRMEDLVFSGAATGDIFIWK--------------DILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWD--DMFERCLKTYAIKRSALSTSSKGLLLE------------DNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVS--FHHRKEMISDIKFSKDTGKYLAVA 1101          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL--PKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            + Y  + +G++Y+   + Q    GH + I       DK  + TG  G+   + IWD      V  + + H +GV  ++   D + LA++  +   T  IWDW  G+   L SA+  ++      IS++     +V +     + F  W   GN    A       F K  G     L L   K     S    G + VW+G ++L++             +   H   I  +        TG   G I+ +D            +F P           + KI        Y +  +I+S  +     + GT  + IF  +  +  K  +I + H +  ++++  HP  PL  TGS    +++W+      I  R   +  ++S+ F   G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA
Sbjct:   36 VVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGK--LLASATGHSDRIFD--ISWDPYQPNRVVSCGVKHIKF--WTLCGN----ALTAKRGIFGK-TGDLQTILCLACAKEDITYSGALNGDIYVWKG-LNLVRT------------IQGAHSAGIFSMYACEEGFATGGRDGCIRLWDT-----------DFKP-----------ITKIDLRETEQGY-KGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI-ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIH--EMKFSPDGSYLA 424          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYI---SFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTR----ALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATV 1980
            PQ      +    +P + ++K P  +L   +  G+  Y    NL       + Y  + + ++Y+   + Q +  GH + I   T    K ++ TG  G ++ + +WD  T   +  +   H  GV A+  + D + L ++  ++  +   WDW  GE +       +T  G ++ I     N   + ++ T     + F+Q    G    F  K   +     +GK   T+      R      S  + G + +W+              D   +K V  HD  +  +       VTG   G ++ +D   M     + +     +  +SS    LE            ++ +I++        +VGT       +   G    ++    +  V+ + AHP LP+ AT S    L+IW    +  +      K   +   F   G  +AVG  +G   +++   ++D++S  FH  K  I+ I+FS+ + ++LA  
Sbjct:  651 PQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKI-------ATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGG----FTSK---RGTFGSVGKL-ETMMCVSYGRMEDLVFSGAATGDIFIWK--------------DILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWD--DMFERCLKTYAIKRSALSTSSKGLLLE------------DNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVS--FHHRKEMISDIKFSKDTGKYLAVA 1101          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL--PKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            + Y  + +G++Y+   + Q    GH + I       DK  + TG  G+   + IWD      V  + + H +GV  ++   D + LA++  +   T  IWDW  G+   L SA+  ++      IS++     +V +     + F  W   GN    A       F K  G     L L   K     S    G + VW+G ++L++             +   H   I  +        TG   G I+ +D            +F P           + KI        Y +  +I+S  +     + GT  + IF  +  +  K  +I + H +  ++++  HP  PL  TGS    +++W+      I  R   +  ++S+ F   G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA
Sbjct:   36 VVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGK--LLASATGHSDRIFD--ISWDPYQPNRVVSCGVKHIKF--WTLCGN----ALTAKRGIFGK-TGDLQTILCLACAKEDITYSGALNGDIYVWKG-LNLVRT------------IQGAHSAGIFSMYACEEGFATGGRDGCIRLWDT-----------DFKP-----------ITKIDLRETEQGY-KGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI-ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIH--EMKFSPDGSYLA 424          

Query: 1534 DYPEDTTIQSNKFAIHDFIVGTATAIFATVT---------VKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDT---HALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLY 2007
            D+  + T+  ++  I++F   + + +  + +         V   +     + H   V+    +P+  L+A+GS+   ++IW      +I +    + P+ S+CF+  G  +A G  +G +RI D+     +K ++ +        ITH++FS   +++   + N T  L+
Sbjct:  137 DFVYEKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVKTLKGHTNYVFCCCFNPSGTLIASGSFDETIRIWCARNGNTIFSIPGHEDPVSSVCFNRDGAYLASGSYDGIVRIWDSTTGTCVKTLIDE----EHPPITHVKFSPNGKYILASNLNNTLKLW 302          

Query:  511 PTPQRILSESKNFE--QLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENS-----DYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF-SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRE 3279
            P+ Q   ++S+ +    LP I ++ N    L   ++ G N  +P+ +L  ++R  I Y+C+H+ +IYD+    Q +LQGH + I+C   S+D+RW+ T D G+ S+VIIWD  TG+PV+T+F+ HP  GV A++L+ D++YL T+ A   Q   IW+WT   + P C   LS  YG Q  I FN  D  Q+ +NS +QVLFY W++ G+L+Y AP++TD+ FN  IG    ++F     +A +ATS G +++W+     +   +     + A+KLV +  +AI VLTL  SFIVTGDV G IKF+D N  L+  Y ++N  P           +  I F  E       +YP+D T+ +  F + +F++ T  A    V  + +  K + R+H + + +V  HP  PLVA GS+SG +K+W+Y+ +E++ +R+F S   I+ + +D  G  +AVGFA+G L+I+D   L +   +   F++  ITH+ FS+ S +LA  D     TL    +   +E W Y  R+ +HYK I DLLFG   D+  PRL +LG DRRLVEYDL ++ E++L IL   RIEQSA+P    WYP    E F++TA++ YK+K++N  +KMCR +   P++GSPVK +  LP + +  S       RY+AY   +K+G+  +PL+GNP+    MI H  GV++L CS+DG Y+ +  G+D  V  W++NL  LEA   LGG GM P+Y+L+EGG  G    E++EYFYY  +  Q +DS++ R V   I +++VP++MRA+GFYP+E+E+E+M NE+KF  Y ET  Y   +DL  FI++YVNHRPA GIS +++   F+ +     EG  +ID+   L LL  +GE + E+DLAE   TLLG   +GG+          +++SV   LP  +T   F  +I+   +  +E
Sbjct:   46 PSQQEDTADSQIYTATSLPAIPKETNKTHPLVLEWAYGINSSLPVFSLQDEDRLVIIYACAHVAVIYDHTSKSQYLLQGHCSPITCLCTSEDRRWIVTADMGQESLVIIWDAYTGIPVKTLFDCHPEGGVAALALSKDSKYLVTVGAGLVQRVCIWNWTDESEEPACQVDLSPKYGCQKQILFNPSDSTQLVSNSSSQVLFYNWER-GHLEYSAPEITDKTFNAVIGSLSQSVFHYDGVQAFTATSNGNIILWDKQTESV---SRQPIVRNAIKLVSMQKEAIAVLTLIDSFIVTGDVNGHIKFYDGNLKLINLYNEFNVDP-----------IRSISFSKERPSNNSLEYPKDCTLDAKPFVMRNFVLSTIHATVVHVNTQTNVPKSLLREHAEPLEAVACHPKQPLVAMGSHSGTIKVWDYQHKEAVCSRVFLSHKQIQCIAYDPQGFYLAVGFASGALQIVDACTLHNDGKECLQFTQDSITHLTFSQDSHYLAAADTGKAVTLLCLCKEGTQEIWKYQGRHHSHYKPIQDLLFGVDLDSNQPRLLSLGMDRRLVEYDLQSSGENELLILSCDRIEQSAVPTCMAWYPHLTPENFLLTASNLYKMKLFNATSKMCRKTLSAPSYGSPVKKMLILPASKDGDS-----NSRYMAYITEDKVGIQILPLDGNPHKSFVMICHSTGVSTLACSYDGRYVFTAGGQDCTVFSWELNLLSLEASAALGGKGMKPFYDLLEGGRDGLLFKEMEEYFYYFQLLDQNLDSMETRLVSTRIPLADVPFLMRALGFYPTEQELEDMQNEVKFSRYAETRNYVTDIDLEEFIRLYVNHRPASGISRQELYNAFQVLGKPDEEGRYNIDRDELLELLQARGEHMTEDDLAECFTTLLGVTPDGGNYT------GSLLESV---LPAEITMDAFASDILGFSVATQE 953          

Query:  511 PTPQRILSESKNFE--QLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENS-----DYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF-SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRE 3279
            P+ Q   ++S+ +    LP I ++ N    L   ++ G N  +P+ +L  ++R  I Y+C+H+ +IYD+    Q +LQGH + I+C   S+D+RW+ T D G+ S+VIIWD  TG+PV+T+F+ HP  GV A++L+ D++YL T+ A   Q   I +WT   + P C   LS  YG Q  I FN  D  Q+ +NS +QVLFY W++ G+L+Y AP++TD+ FN  IG    ++F     +A +ATS G +++W+     +   +     + A+KLV +  +AITVLTL  SFIVTGDV G IKF+D N  L+  Y ++N  P           +  I F  E       +YP+D T+ +  F + +F++ T  A    V  + +  K + R+H + + +V  HP  PLVA GS+SG +K+W+Y+ +E++ +R+F S   I+ + +D  G  +AVGFA+G L+I+D   L +   +   F++  ITH+ FS+ S +LA  D     TL    +   +E W Y  R+ +HYK I DLLFG   D+  PRL +LG DRRLVEYDL ++ E++L IL   RIEQSA+P    WYP    E F++TA++ YK+K++N  +KMCR +   P++GSPVK +  LP + +  S       RY+AY   +K+G+  +PL+GNP+    MI H  GV++L CS+DG Y+ +  G+D  V  W++NL  LEA   LGG GM P+Y+L+EGG  G    E++EYFYY  +  Q +DS++ R V   I +++VP++MRA+GFYP+E+E+E+M NE+KF  Y ET  Y   +DL  FI++YVNHRPA GIS +++   F+ +     EG  +ID+   L LL  +GE + E+DLAE   TLLG   +GG+          +++SV   LP  +T   F  +I+   +  +E
Sbjct:   46 PSQQEDTADSQIYTATSLPAIPKETNKTHPLVLEWAYGINSTLPVFSLQDEDRLVIIYACAHVAVIYDHTSKSQYLLQGHCSPITCLCTSEDRRWIVTADMGQESLVIIWDAYTGIPVKTLFDCHPEGGVAALALSKDSKYLVTVGAGLVQRVCIRNWTDESEEPACQVDLSPKYGCQKQILFNPSDSTQLVSNSSSQVLFYNWER-GHLEYSAPEITDKTFNAVIGSLSQSVFHYDGVQAFTATSDGNIILWDKQTESV---SRQPIVRNAIKLVSMQKEAITVLTLIDSFIVTGDVNGHIKFYDGNLKLINLYNEFNVDP-----------IRSISFSKERPSNNSLEYPKDCTLDAKPFVMRNFVLSTTHATVVHVNTQTNVPKSLLREHAEPLEAVACHPKQPLVAMGSHSGTIKVWDYQHKEAVCSRVFLSHKQIQCIAYDPQGFYLAVGFASGALQIVDACTLHNDGKECLQFTQDSITHLTFSQDSHYLAAADTGKAVTLLCLCKEGTQEIWKYQGRHHSHYKPIQDLLFGVDLDSNQPRLLSLGMDRRLVEYDLQSSGENELLILSCDRIEQSAVPTCMAWYPHLTPENFLLTASNLYKMKLFNATSKMCRKTLSAPSYGSPVKKMLILPASKDGDS-----NSRYMAYITEDKVGIQILPLDGNPHKSFVMICHSTGVSTLACSYDGRYVFTAGGQDCTVFSWELNLLSLEASAALGGKGMKPFYDLLEGGRDGLLFKEMEEYFYYFQLLDQNLDSMETRLVSTRIPLADVPFLMRALGFYPTEQELEDMQNEVKFSRYAETRNYVTDIDLEEFIRLYVNHRPASGISRQELYNAFQVLGKPDEEGRYNIDRDELLELLQARGEHMTEDDLAECFTTLLGVTPDGGNYT------GSLLESV---LPAEITMDAFASDILGFSVATQE 953          

Query:  511 PTPQRILSESKNFE--QLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENS-----DYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF-SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGE 3087
            P+ Q   ++S+ +    LP I ++ N    L   ++ G N  +P+ +L  ++R  I Y+C+H+ +IYD+    Q +LQGH + I+C   S+D+RW+ T D G+ S+VIIWD  TG+PV+T+F+ HP  GV A++L+ D++YL T+ A   Q   I +WT   + P C   LS  YG Q  I FN  D  Q+ +NS +QVLFY W++ G+L+Y AP++TD+ FN  IG    ++F     +A +ATS G +++W+     +   +     + A+KLV +  +AITVLTL  SFIVTGDV G IKF+D N  L+  Y ++N  P           +  I F  E       +YP+D T+ +  F + +F++ T  A    V  + +  K + R+H + + +V  HP  PLVA GS+SG +K+W+Y+ +E++ +R+F S   I+ + +D  G  +AVGFA+G L+I+D   L +   +   F++  ITH+ FS+ S +LA  D     TL    +   +E W Y  R+ +HYK I DLLFG   D+  PRL +LG DRRLVEYDL ++ E++L IL   RIEQSA+P    WYP    E F++TA++ YK+K++N  +KMCR +   P++GSPVK +  LP + +  S       RY+AY   +K+G+  +PL+GNP+    MI H  GV++L CS+DG Y+ +  G+D  V  W++NL  LEA   LGG GM P+Y+L+EGG  G    E++EYFYY  +  Q +DS++ R V   I +++VP++MRA+GFYP+E+E+E+M NE+KF  Y ET  Y   +DL  FI++YVNHRPA GIS +++   F+ +     EG  +ID+   L LL  +G+
Sbjct:   46 PSQQEDTADSQIYTATSLPAIPKETNKTHPLVLEWAYGINSTLPVFSLQDEDRLVIIYACAHVAVIYDHTSKSQYLLQGHCSPITCLCTSEDRRWIVTADMGQESLVIIWDAYTGIPVKTLFDCHPEGGVAALALSKDSKYLVTVGAGLVQRVCIRNWTDESEEPACQVDLSPKYGCQKQILFNPSDSTQLVSNSSSQVLFYNWER-GHLEYSAPEITDKTFNAVIGSLSQSVFHYDGVQAFTATSDGNIILWDKQTESV---SRQPIVRNAIKLVSMQKEAITVLTLIDSFIVTGDVNGHIKFYDGNLKLINLYNEFNVDP-----------IRSISFSKERPSNNSLEYPKDCTLDAKPFVMRNFVLSTTHATVVHVNTQTNVPKSLLREHAEPLEAVACHPKQPLVAMGSHSGTIKVWDYQHKEAVCSRVFLSHKQIQCIAYDPQGFYLAVGFASGALQIVDACTLHNDGKECLQFTQDSITHLTFSQDSHYLAAADTGKAVTLLCLCKEGTQEIWKYQGRHHSHYKPIQDLLFGVDLDSNQPRLLSLGMDRRLVEYDLQSSGENELLILSCDRIEQSAVPTCMAWYPHLTPENFLLTASNLYKMKLFNATSKMCRKTLSAPSYGSPVKKMLILPASKDGDS-----NSRYMAYITEDKVGIQILPLDGNPHKSFVMICHSTGVSTLACSYDGRYVFTAGGQDCTVFSWELNLLSLEASAALGGKGMKPFYDLLEGGRDGLLFKEMEEYFYYFQLLDQNLDSMETRLVSTRIPLADVPFLMRALGFYPTEQELEDMQNEVKFSRYAETRNYVTDIDLEEFIRLYVNHRPASGISRQELYNAFQVLGKPDEEGRYNIDRDELLELLQARGK 898          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGK----------FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSE-KSEFLATVDGNFTTTLY 2007
            PQ      +    +    +++ P S +   +  G+  Y    NL       I Y  + +G++Y+   N Q    GH + I C      K ++ TG  G +S + IW+     P+  +   H  GV A+  + D + LA++  ++  T  +W+W  GE        LST  G +       D IF +  N       Y  DK+ +      K   +     IGK           C  ++        S T  G + +W               D   VK V  HD  +  +       VTG   G +  +D  +   +  +  +     P S               +LE+     + +I++        +VGT       V  K   I ++ + H +  V+ +  HP LPL AT S    L+IW+      +      K   +  CF   G  +AVG  +G   I++   L+D++S  FH  K  I+ I+FS    ++LA   G+    +Y
Sbjct:  651 PQLKEQCKEKHRAMAMKKRERAPASGMRLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNRQQNTQRFYLGHDDDILCLAIHPVKDYVATGQVGRDSSIHIWETEFLKPLSVLKGFHQFGVCALDFSADGKRLASVGLDDNHTIVLWEWRKGE-------KLSTIRGSK-------DKIFVIKINP------YMPDKLISAGVKHMKFWHRAGGGLIGKKGSMGKTETMMC-AVYGWTEEMVFSGTCTGDICIWR--------------DMFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDTFERCLKTYAIKRAVLAPGSK------------GLLLED-----NPSIRAISLGHGHILVGTKNGEILEVD-KNGPITLLVQGHMEGEVWGLATHPHLPLCATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLIVNADTLEDLVS--FHHRKDIISEIRFSPVTGKYLAVASGDSFVDIY 1107          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRAL--SATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGE---LRILDT-------------HALK-----------------DVLSKPFHFSKVH--------ITHIQFSEKSEFLATVDGNFTTTLYR 2010
            I Y  + +G++Y+   ++Q    GH + I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  +D + L ++  ++  T  +WDW  G+        L+   G  + I     D++Q +      V   + W   GN     PK   +      G     L L      +  S    G + VW+G ++LI+    +            H   I  +        TG   G I+ +D            NF PI+            +  + E     +  +++S  +     +VGT  + IF  V    +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+       G+ +A+G  +G    LR+ D              H LK                 D+      + KV         ITH+ +S  S++L T DGN     YR
Sbjct:   36 IVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILRDMHTHGIACLAFDLDGQCLVSVGLDSKNTICVWDWRQGK-------VLAAAPGHTDRIFDISWDLYQQSKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGKTGDLQTILCLACARDEITYSGALNGDIYVWKG-INLIRTVQGA------------HGSGIFSMNACEEGFATGGRDGCIRLWDL-----------NFKPIT------------VIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEVVVHDRTKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSL-VDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAHLAVGSNDNSVDIYGVVQRYKKVGECVGSSSFITHMDWSTDSKYLQTNDGNGRRLFYR 479          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGK----------FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSE-KSEFLATVDGNFTTTLY 2007
            PQ      +    +    +++ P S +   +  G+  Y    NL       I Y  + +G++Y+   N Q    GH + I C      K ++ TG  G +S + IW+     P+  +   H  GV A+  + D + LA++  ++  T  +W+W  GE        LST  G +       D IF +  N       Y  DK+ +      K   +     IGK           C  ++        S T  G + +W               D   VK V  HD  +  +       VTG   G +  +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       V  K   I ++ + H +  V+ +  HP LPL AT S    L+IW+      +      K   +  CF   G  +AVG  +G   I++   L+D++S  FH  K  I+ I+FS    ++LA   G+    +Y
Sbjct:  651 PQLKEQCKEKHRAMAMKKRERAPASGMRLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNRQQNTQRFYLGHDDDILCLAIHPVKDYVATGQVGRDSSIHIWETEFLKPLSVLKGFHQFGVCALDFSADGKRLASVGLDDNHTIVLWEWRKGE-------KLSTIRGSK-------DKIFVIKINP------YMPDKLISAGVKHMKFWHRAGGGLIGKKGSMGKTETMMC-AVYGWTEEMVFSGTCTGDICIWR--------------DMFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDTFERCLKTYAIKRAVLAPGSK------------GLLLE-----DNPSIRAISLGHGHILVGTKNGEILEVD-KNGPITLLVQGHMEGEVWGLATHPHLPLCATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLIVNADTLEDLVS--FHHRKDIISEIRFSPVTGKYLAVASGDSFVDIY 1107          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRAL--SATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGE---LRILDT-------------HALK-----------------DVLSKPFHFSKVH--------ITHIQFSEKSEFLATVDGNFTTTLYR 2010
            I Y  + +G++Y+   ++Q    GH + I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  +D + L ++  ++  T  +WDW  G+        L+   G  + I     D++Q +      V   + W   GN     PK   +      G     L L      +  S    G + VW+G ++LI+    +            H   I  +        TG   G I+ +D            NF PI+            +  + E     +  +++S  +     +VGT  + IF  V    +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+       G+ +A+G  +G    LR+ D              H LK                 D+      + KV         ITH+ +S  S++L T DGN     YR
Sbjct:   36 IVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILRDMHTHGIACLAFDLDGQCLVSVGLDSKNTICVWDWRQGK-------VLAAAPGHTDRIFDISWDLYQQSKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGKTGDLQTILCLACARDEITYSGALNGDIYVWKG-INLIRTVQGA------------HGSGIFSMNACEEGFATGGRDGCIRLWDL-----------NFKPIT------------VIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEVVVHDRTKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSL-VDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAHLAVGSNDNSVDIYGVVQRYKKVGECVGSSSFITHMDWSTDSKYLQTNDGNGRRLFYR 479          

Query:  607 YSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEG--NVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINEND 3105
            +S G N  +P+ N   + R  I Y+C+H  +I+D   N Q  LQGH + ISC   S+++RW+ T DQG  S++IIWD  +G+PV T+F  HP  GV+A+S + + +              IW+WTT    P+CSA L   +G+Q YI FN  D  Q+ T+SETQV+FY W +    K      T   FNK +G+F  ++F    TRAL+ TS G LVVWE   + S+    +     KKA+KL+ +   AITVL+    + VTGDV G +KF+D    L+ WY      P+ SIS ST   +         + YP+D +I+ ++FAI +FIV T  ++   V   G+ +K    +  ++V+++  HP   L+A GSYSGLLK+WNY+ R+   +R+F K   +  L +D  G  +  GF +G + ILD   L+D +++PF +++  ITHI FS  S++LAT             +N V   W Y  RYR+HYKKI  L+FG + DT  PRL +LG DR LVEYDL N  +  L I    RIEQSA+P +  WYP    E FI+ AND YK+K+YN  TKMCR + LGPTFGSPV+ ++ LP      + ++ + + Y+ Y   +K+GL  +PL+GNP+  M++I HP GV++L CS+DG ++ + G +D  V +WK NL  LE+   LGGDG+TP+Y L++GG  G    EL+ YFYY+ +R QGID+++ R V   I + EVP+IMRA+G+YPSE+E+ENMLNE+KF +Y +TGK    + L   IK+Y+NHRPAFG+  E+I+  F+ +   + +G+ +I++  FL +L ++G++ ++  
Sbjct:   73 WSFGLNNKIPVFNFYDEERQVIVYACAHTAVIHDISQNRQHHLQGHCSCISCMCVSEERRWIATADQGTESLIIIWDSFSGIPVHTIFNSHPEGGVIAMSFSHNGK------------VCIWEWTTDTGKPICSAELRQEFGIQTYIVFNAQDQTQLVTSSETQVIFYTWVRKKCRK--CSIYTVYTFNKVVGEFSQSVFDFSATRALTGTSAGKLVVWETIHSPSIKATSSIQPHKKKALKLMHLQKDAITVLSTHDRYFVTGDVQGHVKFYDQRLQLVNWYSHLTLRPVRSISFSTCPPVTASG----RTRYPQDCSIKGDQFAISNFIVSTVDSVVLHVHTDGTVLKEHMHEPSEAVHALACHPCEHLIAIGSYSGLLKVWNYKARKLFISRIFGKGKSLHCLSYDPKGFLLGAGFTDGSVYILDAMTLEDEIAEPFKYARGSITHIAFSHDSQYLATA----------VKKNGVT--WQYFGRYRSHYKKIQSLVFGIHLDTNEPRLISLGMDRMLVEYDLANCVKGYLQIKSTDRIEQSAVPQSLAWYPPVTKECFILVANDHYKMKLYNATTKMCRKTLLGPTFGSPVRRMEVLP------TYSEEICKGYMTYITDDKVGLQILPLDGNPHKSMSLICHPDGVSNLACSYDGCFVFTAGGDDCTVLMWKTNLQALESVSSLGGDGLTPFYGLLQGGREGLLFKELENYFYYAQLRHQGIDTMETRQVSTHIPLKEVPFIMRALGYYPSEQEVENMLNEVKFSEYVDTGKQVTCISLEELIKLYINHRPAFGLFMEEIQWAFQVLGFTNGDGKQTINRGDFLQILQSRGKETSQTS 878          

Query:  607 YSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEG--NVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINE 3099
            +S G N  +P+ N   + R  I Y+C+H  +I+D   N Q  LQGH + ISC   S+++RW+ T DQG  S++IIWD  +G+PV T+F  HP  GV+A+S + + +YLAT+     Q   IW+WTT    P+CSA LS N    ++ S                                     Q FNK +G+F  ++F    TRAL+ TS G LVVWE   + S+    +     KKA+KL+ +   AITVL+    + VTGDV G +KF+D    L+ WY      P+ SIS ST   +         + YP+D +I+ ++FAI +FIV T  ++   V   G+ +K    +  ++V+++  HP   L+A GSYSGLLK+WNY+ R+   +R+F K   +  L +D  G  +  GF +G + ILD   L+D +++PF +++  ITHI FS  S++LAT D  FT TL++  R      W Y  RYR+HYKKI  L+FG + DT  PRL +LG DR LVEYDL N  +  L I    RIEQSA+P +  WYP    E FI+ AND YK+K+YN  TKMCR + LGPTFGSPV+ ++ LP      + ++ + + Y+ Y   +K+GL  +PL+GNP+  M++I HP GV++L CS+DG ++ +  G+D  V +WK NL  LE+   LGGDG+TP+Y L++GG  G    EL+ YFYY+ +R QGID+++ R V   I + EVP+IMRA+G+YPSE+E+ENMLNE+KF +Y +TGK    + L   IK+Y+NHRPAFG+  E+I+  F+ +   + +G+ +I++  FL +L ++G++ ++
Sbjct:  111 WSFGLNNKIPVFNFYDEERQVIVYACAHTAVIHDISQNRQHHLQGHCSCISCMCVSEERRWIATADQGTESLIIIWDSFSGIPVHTIFNSHPEGGVIAMSFSHNGKYLATVGGGTKQRVCIWEWTTDTGKPICSAELSNNVAFIHFYSL------------------------------------QTFNKVVGEFSQSVFDFSATRALTGTSAGKLVVWETIHSPSIKATSSIQPHKKKALKLMHLQKDAITVLSTHDRYFVTGDVQGHVKFYDQRLQLVNWYSHLTLRPVRSISFSTCPPVTASG----RTRYPQDCSIKGDQFAISNFIVSTVDSVVLHVHTDGTVLKEHMHEPSEAVHALACHPCEHLIAIGSYSGLLKVWNYKARKLFISRIFGKGKSLHCLSYDPKGFLLGAGFTDGSVYILDAMTLEDEIAEPFKYARGSITHIAFSHDSQYLATADTEFTVTLFKLSREKNGVTWQYFGRYRSHYKKIQSLVFGIHLDTNEPRLISLGMDRMLVEYDLANCVKGYLQIKSTDRIEQSAVPQSLAWYPPVTKECFILVANDHYKMKLYNATTKMCRKTLLGPTFGSPVRRMEVLP------TYSEEICKGYMTYITDDKVGLQILPLDGNPHKSMSLICHPDGVSNLACSYDGCFVFTAGGDDCTVLMWKTNLQALESVSSLGGDGLTPFYGLLQGGREGLLFKELENYFYYAQLRHQGIDTMETRQVSTHIPLKEVPFIMRALGYYPSEQEVENMLNEVKFSEYVDTGKQVTCISLEELIKLYINHRPAFGLFMEEIQWAFQVLGFTNGDGKQTINRGDFLQILQSRGKETSQ 904          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRA----LSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFS-EKSEFLATV 1980
            PQ      +  + LP + ++K P  +L   +  G+  Y    NL       + Y  + + ++YD   + Q    GH + I        K ++ TG  G ++ + +WD  T   +  +   H  GV A+  + D + L ++  ++  T   WDW  GE +          +     +  N     ++ T     + F+Q    G    F  K   +     IGK   T+      RA     S  + G + +W+  V L              K +  HD  +  +       VTG   G ++ +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       +   G    ++    +  V+ +  HP LPL AT S    L+IW   ++  +      K   +   F   G  +AVG ++G   +++   L+D++S  FH  K  I  I+FS +  ++LA  
Sbjct:  651 PQLKQQNKEKQQSLPSLKREKAPDESLKLKFVHGYRGYDCRNNLFYTQAGEVVYHVAAIAVVYDRLQHSQRFYLGHDDDILSLAIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVSALDFSADGKCLVSVGLDDNHTIVYWDWKKGEKIACTRGHKDKIF----VVKCNPHHTDKLVTVGMKHIKFWQQTGGG----FTAK---RGTFGTIGKL-ETMMCVSYGRAEDLVFSGAATGDIYIWKDVVLL--------------KTIKAHDGPVFAMYALDKGFVTGGKDGVVELWDDMFERCLKTYAIKRAALSPSSK------------GLLLE-----DNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLATHPQLPLCATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLSDGSFLVVNADTLEDMVS--FHHRKEIIADIKFSPDAGKYLAVA 1101          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDK-----IGNLKYFAPKLTDQDFNKPIGKFCHT--------LFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            + Y  + +G++Y+   + Q    GH + I       D+  + TG  G++  + IWD  T   V  + + H +GV  ++   + + LA++  +   T  IWDW  G+        L+T  G       + D IF ++ +       YQ ++     + ++K++   L         G F  T        L   K     S    G + VW+G ++L +             +   H   I  +        TG   G I+ +D ++                       ++ KI        Y +  +I+S  +     + GT  + IF  +  +  K  +I + H +  ++++  HP  PL  TGS    +++W+      I  R   +  ++S+ F   G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA
Sbjct:   36 VVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDRTLVATGQVGKDPYICIWDSYTVQTVSILKDVHTHGVAGLAFDSEGQRLASVGLDAKNTVCIWDWQKGK-------VLATATG-------HSDRIFDISWDP------YQPNRLVSCGVKHIKFWT--LCGNALTAKRGIFGKTGDLQTILCLACAKEDVTYSGALNGDIYVWKG-LTLART------------IQGAHSAGIFSMYACEEGFATGGRDGCIRLWDADF----------------------KAITKIDLRESEQGY-KGLSIRSVCWKADRILAGTQDSEIFEVMVRERDKPMLIMQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI-ARCNMEEAVRSVAFISDGSQLALGMKDGSFTVLRVRDMTEVVHIKDRKEVIH--EMKFSPDGSYLA 424          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRA----LSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFS-EKSEFLATV 1980
            PQ      +  + LP + ++K P  +L   +  G+  Y    NL       + Y  + + ++YD   + Q    GH + I        K ++ TG  G ++ + +WD  T   +  +   H  GV A+  + D + L ++  ++  T   WDW  GE +          +     +  N     ++ T     + F+Q    G    F  K   +     IGK   T+      RA     S  + G + +W+  V L              K +  HD  +  +       VTG   G ++ +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       +   G    ++    +  V+ +  HP LPL AT S    L+IW   ++  +      K   +   F   G  +AVG ++G   +++   L+D++S  FH  K  I  I+FS +  ++LA  
Sbjct:  651 PQLKQQNKEKQQSLPSLKREKAPDESLKLKFVHGYRGYDCRNNLFYTQAGEVVYHVAAIAVVYDRLQHSQRFYLGHDDDILSLAIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVSALDFSADGKCLVSVGLDDNHTIVYWDWKKGEKIACTRGHKDKIF----VVKCNPHHTDKLVTVGMKHIKFWQQTGGG----FTAK---RGTFGTIGKL-ETMMCVSYGRAEDLVFSGAATGDIYIWKDVVLL--------------KTIKAHDGPVFAMYALDKGFVTGGKDGVVELWDDMFERCLKTYAIKRAALSPSSK------------GLLLE-----DNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLATHPQLPLCATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLSDGSFLVVNADTLEDMVS--FHHRKEIIADIKFSPDAGKYLAVA 1101          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDK-----IGNLKYFAPKLTDQDFNKPIGKFCHT--------LFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            + Y  + +G++Y+   + Q    GH + I       D+  + TG  G++  + IWD  T   V  + + H +GV  ++   + + LA++  +   T  IWDW  G+        L+T  G       + D IF ++ +       YQ ++     + ++K++   L         G F  T        L   K     S    G + VW+G ++L +             +   H   I  +        TG   G I+ +D ++                       ++ KI        Y +  +I+S  +     + GT  + IF  +  +  K  +I + H +  ++++  HP  PL  TGS    +++W+      I  R   +  ++S+ F   G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA
Sbjct:   36 VVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDRTLVATGQVGKDPYICIWDSYTVQTVSILKDVHTHGVAGLAFDSEGQRLASVGLDAKNTVCIWDWQKGK-------VLATATG-------HSDRIFDISWDP------YQPNRLVSCGVKHIKFWT--LCGNALTAKRGIFGKTGDLQTILCLACAKEDVTYSGALNGDIYVWKG-LTLART------------IQGAHSAGIFSMYACEEGFATGGRDGCIRLWDADF----------------------KAITKIDLRESEQGY-KGLSIRSVCWKADRILAGTQDSEIFEVMVRERDKPMLIMQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI-ARCNMEEAVRSVAFISDGSQLALGMKDGSFTVLRVRDMTEVVHIKDRKEVIH--EMKFSPDGSYLA 424          

Query:  517 PQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRA----LSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFS 1953
            PQ      +  + LP + ++K P  +L   +  G+  Y    NL       + Y  + + ++YD   + Q    GH + I        K ++ TG  G ++ + +WD  T   +  +   H  GV A+  + D + L ++  ++  T   WDW  GE +          +     +  N     ++ T     + F+Q    G   + A + T   F   IGK   T+      RA     S  + G + +W+  V L              K +  HD  +  +       VTG   G ++ +D   M     + +     +   SS    LE            ++ +I++        +VGT       +   G    ++    +  V+ +  HP LPL AT S    L+IW   ++  +      K   +   F   G  +AVG ++G   +++   L+D++S  FH  K  I  I+FS
Sbjct:  651 PQLKQQNKEKQQSLPSLKREKAPDESLKLKFVHGYRGYDCRNNLFYTQAGEVVYHVAAIAVVYDRLQHSQRFYLGHDDDILSLAIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVSALDFSADGKCLVSVGLDDNHTIVYWDWKKGEKIACTRGHKDKIF----VVKCNPHHTDKLVTVGMKHIKFWQQTGGG---FTAKRGT---FG-TIGKL-ETMMCVSYGRAEDLVFSGAATGDIYIWKDVVLL--------------KTIKAHDGPVFAMYALDKGFVTGGKDGVVELWD--DMFERCLKTYAIKRAALSPSSKGLLLE------------DNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLATHPQLPLCATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLSDGSFLVVNADTLEDMVS--FHHRKEIIADIKFS 1091          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDK-----IGNLKYFAPKLTDQDFNKPIGKFCHT--------LFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            + Y  + +G++Y+   + Q    GH + I       D+  + TG  G++  + IWD  T   V  + + H +GV  ++   + + LA++  +   T  IWDW  G+        L+T  G       + D IF ++ +       YQ ++     + ++K++   L         G F  T        L   K     S    G + VW+G ++L +             +   H   I  +        TG   G I+ +D ++                       ++ KI        Y +  +I+S  +     + GT  + IF  +  +  K  +I + H +  ++++  HP  PL  TGS    +++W+      I  R   +  ++S+ F   G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA
Sbjct:   36 VVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDRTLVATGQVGKDPYICIWDSYTVQTVSILKDVHTHGVAGLAFDSEGQRLASVGLDAKNTVCIWDWQKGK-------VLATATG-------HSDRIFDISWDP------YQPNRLVSCGVKHIKFWT--LCGNALTAKRGIFGKTGDLQTILCLACAKEDVTYSGALNGDIYVWKG-LTLART------------IQGAHSAGIFSMYACEEGFATGGRDGCIRLWDADF----------------------KAITKIDLRESEQGY-KGLSIRSVCWKADRILAGTQDSEIFEVMVRERDKPMLIMQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI-ARCNMEEAVRSVAFISDGSQLALGMKDGSFTVLRVRDMTEVVHIKDRKEVIH--EMKFSPDGSYLA 424          

Query:  469 KDTKIYISHSENHSPTPQRILSESKN-----FEQLPQISQDK-----------------------NPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDK-------KAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQV 3288
            KD  + +  +E  S  P+ IL++ K+      E+  ++ Q K                       + V  L+  +S G+N  +P+  +  D R  I Y+C+H  I+YD   N Q  LQGH N ISC   S+D+RW+ T D+G + ++IIWD  TG+PV T+F+  P  NG+ +I++T D+++LAT+S   TQ   IW WT   + P C+  L   YG Q+ + FN  +  ++ +NS+TQ ++Y W +  G L + AP LT++ FNK +GKF  ++F  K  + LSAT +G LVVW+     I  P+ ++S         K  KLV +  +AITVL    S+IVTGD+ G+IKF+D+   ++ WY ++  G I ++S S +          E S+ P D T++ + F + +FI+GT  A    +TV G+K++ +F +   +VY+V  HP  PL+A GS  G++K+W++E +  + +R F K + ++ L ++  G  +  GF  G + ILD  +L++   +PF +SK  ++H  FS  S ++AT D NFT  +Y     N +  W Y+AR R+H   I  LLFG + D+  PRL +LG+DR L+EY+L  + +D L +L   R +Q   P    WYP    E F++  N  YK+K++N  TKMCR + LGP +GSP++  + LP+ +        +++RYL + N++K+GL  +P++GNP+    ++ HP GV  +  S+DG +  + G +D  V  WKINL  LEA   LGG+ +TP+Y L+ GG  G F  EL++YFYYS IR+QGID+++ R V   I +SE+P++MRAIGFYPSEE+IE+M NE+KF +Y ETGK  DK++L  F+KVY+NHRP FG + + I+ +F  +   ++EG+ +I +  FLNLL+ KGE + E ++ +  +TL G   EG   E      +     + + LP+ +T + F   I+ + + D   Q+
Sbjct:  329 KDNSMKVDDTEEASQKPEDILAQGKDEARLSLEERRKLFQSKGLSAEESLVSVSTEDTLFQKEEDSKVYPLSMTWSFGWNSSLPVYYMREDRR-VILYTCAHTAIMYDVVRNTQYHLQGHPNIISCLCVSEDRRWIATADEGPDCLIIIWDSFTGIPVHTIFDSCPEGNGMRSIAITRDSKFLATISDSATQKVCIWKWTLAVETPACTLELPKEYGFQDNLVFNPANNKELVSNSKTQAIYYCWFEDKGILAHSAPVLTEKTFNKLVGKFSQSVFHLKLPQVLSATKEGKLVVWD-----IHYPSSTSSSAISAFPFIKPRKLVHLQKEAITVLMTIDSYIVTGDIKGNIKFYDHTLSVVNWYSNFKLGAIRTLSFSKTIP----SLPTEKSNLPTDCTLRGDLFVVRNFIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTFEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVAVYMVVVKNGQRVWEYLARLRSHQNSIQSLLFGVHLDSNEPRLLSLGKDRFLIEYNLVKSCKDHLDVLDVHRTDQGNYPTCMIWYPPLTKELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEHAQVLPVKSTLE-----LQKRYLVFINKDKVGLQILPVDGNPHKTCAIVCHPNGVAGMALSYDGRFAFTAGGQDRSVVQWKINLGALEAAVSLGGEDLTPFYGLVSGGREGKFYRELEDYFYYSQIRSQGIDTMETRQVSEHICLSELPFVMRAIGFYPSEEKIEDMFNEIKFSEYVETGKLIDKINLPDFLKVYLNHRPPFGNTMDGIQNSFNVLGYTNSEGKKAIRREDFLNLLLTKGEHMTEEEMIDCFSTLFGLTPEGWKSEPAATCINGPEICLQKELPEEITAEIFTTEILGLTLSDSSEQL 1297          

Query:  850 LPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW--DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDK-------KAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCR 2340
            +PV T+F+  P  NG+ +I++T D+++LAT+S   TQ   IW WT   + P C+  L   YG Q+ + FN  +  ++ +NS+TQ ++Y W  DK G L + AP LT++ FNK +GKF  ++F  K  + LSAT +G LVVW+     I  P+ ++S         K  KLV +  +AITVL    S+IVTGD+ G+IKF+D+   ++ WY ++  G I ++S S +          E S+ P D T++ + F + +FI+GT  A    +TV G+K++ +F +   +VY+V  HP  PL+A GS  G++K+W++E +  + +R F K + ++ L ++  G  +  GF  G + ILD  +L++   +PF +SK  ++H  FS  S ++AT D NFT  +Y     N +  W Y+AR R+H   I  LLFG + D+  PRL +LG+DR L+EY+L  + +D L +L   R +Q   P    WYP    E F++  N  YK+K++N  TKMCR
Sbjct:   44 IPVHTIFDSCPEGNGMRSIAITRDSKFLATISDSATQKVCIWKWTLAVETPACTLELPKEYGFQDNLVFNPANNKELVSNSKTQAIYYCWFEDK-GILAHSAPVLTEKTFNKLVGKFSQSVFHLKLPQVLSATKEGKLVVWD-----IHYPSSTSSSAISAFPFIKPRKLVHLQKEAITVLMTIDSYIVTGDIKGNIKFYDHTLSVVNWYSNFKLGAIRTLSFSKTIP----SLPTEKSNLPTDCTLRGDLFVVRNFIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTFEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVAVYMVVVKNGQRVWEYLARLRSHQNSIQSLLFGVHLDSNEPRLLSLGKDRFLIEYNLVKSCKDHLDVLDVHRTDQGNYPTCMIWYPPLTKELFLLICNSGYKVKLFNATTKMCR 542          

Query:  895 AISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDK-------KAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENG 2268
            +I++T D+++LAT+S   TQ   IW WT   + P C+  L   YG Q+ + FN  +  ++ +NS+TQ ++Y W +  G L + AP LT++ FNK +GKF  ++F  K  + LSAT +G LVVW+     I  P+ ++S         K  KLV +  +AITVL    S+IVTGD+ G+IKF+D+   ++ WY ++  G I ++S S +          E S+ P D T++ + F + +FI+GT  A    +TV G+K++ +F +   +VY+V  HP  PL+A GS  G++K+W++E +  + +R F K + ++ L ++  G  +  GF  G + ILD  +L++   +PF +SK  ++H  FS  S ++AT D NFT  +Y     N +  W Y+AR R+H   I  LLFG + D+  PRL +LG+DR L+EY+L  + +D L +L   R +Q   P    WYP   G
Sbjct:    3 SIAITRDSKFLATISDSATQKVCIWKWTLAVETPACTLELPKEYGFQDNLVFNPANNKELVSNSKTQAIYYCWFEDKGILAHSAPVLTEKTFNKLVGKFSQSVFHLKLPQVLSATKEGKLVVWD-----IHYPSSTSSSAISAFPFIKPRKLVHLQKEAITVLMTIDSYIVTGDIKGNIKFYDHTLSVVNWYSNFKLGAIRTLSFSKTIP----SLPTEKSNLPTDCTLRGDLFVVRNFIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTFEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVAVYMVVVKNGQRVWEYLARLRSHQNSIQSLLFGVHLDSNEPRLLSLGKDRFLIEYNLVKSCKDHLDVLDVHRTDQGNYPTCMIWYPPLQG 460          

Query: 2344 SFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSI--DKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQV 3288
            + LGP +GSP++  + LP+ +        +++RYL + N++K+GL  +P++GNP+    ++ HP GV  +  S+DG +  + G +D  V  WKINL  LEA   LGG+ +TP+Y L+ GG  G F  EL++YFYYS IR+QGID+++ R V   I +SE+P++MRAIGFYPSEE+IE+M NE+KF +Y ETGK  DK++L  F+KVY+NHRP FG + + I+ +F  +   ++EG+ +I  + FLNLL+ KGE + E ++ +  +TL G   EG   E      +     + + LP+ +T + F   I+ + + D   Q+
Sbjct:    9 TLLGPAYGSPIEHAQVLPVKSTLE-----LQKRYLVFINKDKVGLQILPVDGNPHKTCAIVCHPNGVAGMALSYDGRFAFTAGGQDRSVVQWKINLGALEAAVSLGGEDLTPFYGLVSGGREGKFYRELEDYFYYSQIRSQGIDTMETRQVSEHICLSELPFVMRAIGFYPSEEKIEDMFNEIKFSEYVETGKLIDKINLPDFLKVYLNHRPPFGNTMDGIQNSFNVLGYTNSEGKKAIRREDFLNLLLTKGEHMTEEEMIDCFSTLFGLTPEGWKSEPAATCINGPEICLQKELPEEITAEIFTTEILGLTLSDSSEQL 323          

Query:  571 QDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKT------------TRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATVDGNFTTTLY 2007
            +++ P +++   +  G+  Y    NL       I Y  + +G+IY+   N Q    GH + I C      K ++ TG  G +  + +WD  T  P+  +   H  G+ A+  + D + LA++  +++ T  +WDW  GE        LS   G +       D IF V  N       Y  DK+        K   +     IGK  +   L K               A S TS G + +W               D   VK V  HD  +  +       VTG   G +  +D ++   +  +  +  +  P S               +LE     ++ +I++        +VGT       V  K   I ++ + H +  V+ +  HP LP+ AT S    L+IW+      +      K   +  CF   G  +AVG  +G   + +   L+D++S  FH  K  I+ I+FS  S ++LA    +    +Y
Sbjct:  669 RERTPGTSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDPSIHVWDTETIKPLSILKGYHQYGICAVDFSADGKRLASVGIDDSHTIVLWDWKKGE-------KLSVTRGSK-------DKIFVVKMNP------YVPDKLITAGIKHMKFWRRAGGGLIGKKGYVGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWR--------------DVFLVKTVKAHDGPVFSMHALEKGFVTGGKDGMVALWDDSFERCLKTYAIKRADLAPGSK------------GLLLE-----DNPSIRAISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVS--FHHRKDIISDIRFSPGSGKYLAVASHDSFVDIY 1110          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRAL--SATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGE---LRILDT-------------HALK-----------------DVLSKPFHFSKVH--------ITHIQFSEKSEFLATVDGNFTTTLYR-PGRNNV 2028
            I Y  + +G++Y    + Q   +GH++ I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  +D + L ++  ++     +WDW  G         LS   G  + I     D++Q        V   + W   GN     PK   +      G     L L      L  S    G + VW+G ++LI+             +   H   I  +        TG   G I+ +D             F PI+            +  + E     +  +++S  +     +VGT  + IF  V  + +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+    +  G+ +A+G  +G    LR+ D              H LK                 D+      + KV         ITH+ +S  S +L T DG+    LY+ PG   V
Sbjct:   36 IVYFVAGVGVVYSPREHRQKFFRGHSDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGR-------MLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKG-INLIRT------------IQGAHTAGIFSMNSCEEGFATGGRDGCIRLWDL-----------TFKPIT------------VIDLRETEQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSL-VDHALIARCNMEEPIRCAAVNVDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDIYGVAQRYKKVGECVGSLSFITHLDWSSDSRYLQTNDGSGKRLLYKMPGGKEV 486          

Query:  571 QDKN-PVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSD------KKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQ 3285
            +DK+ PV  LT  +S G+N  +P+  +  + +  + Y C+H  IIY+ + N Q  LQGH N ISC   S+D+RW+ T D+G + +VIIWD  TG+PV T+F+  P  NG++A+++T DA+YLAT+S    Q   IW WT   + P C+  L T YG+QNY++FN  +  ++ +NS+T+ ++Y W ++   L + AP LT++ FNK +GKF  ++F    T+ LSAT +G LVVW+     I  P  S S        K  KLV +  + ITVLT   S+IVTGD+ G+IKF+D+   ++ WY     G I ++S S + +        E S+YP D T++ + F + +FI+GT+ A    +T  G+K++ +F +   ++ ++  HP  PL+A GS  G++K+WNYE ++ + +R+F K + ++SL ++  G  +  GF  G + ILD  +L++   +PF +S+  +THI FS  S+++AT D +FT  +Y     N +  W Y+AR R+H K I  LLFG Y D+  PRL +LG DR L+EYDL  + +D L +L     +Q   P    WYP    E F++  N  YK+K++N  TKMCR + LGP +GSP++  + LP+    RS+ + +++RYL + NR+K+GL  +P++GNP+    ++ HP GV  +  S+DG Y  +  G D  V  WKI L +LEA   LGG+ +TP+Y L+ GG  G F  EL++YFYYS +R+QGID+++ R V   I +SE+P++MRAIGFYPSEE+I+++ NE+KF +Y +TGK  DK++L  F+KVY+NH+P FG +   I ++F  +   +++G+ +I +  FL LL+ KGE + E ++ +  A+L G N EG   E    +       + E LP  +T + F   I+ + I +   Q
Sbjct:  240 KDKSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHLNLTQILSATMEGKLVVWD-----IHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPT----EKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSNEPRLLSLGTDRLLIEYDLLRSYKDHLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEQTQVLPV----RSMAE-LQKRYLVFINRDKVGLQILPVDGNPHKTSAIVCHPNGVAGMAVSYDGCYAFTAGGHDRSVVQWKITLSVLEAAVSLGGEDLTPFYGLLSGGREGKFYRELEDYFYYSQLRSQGIDTMETRKVSEHICLSELPFVMRAIGFYPSEEKIDDIFNEIKFGEYVDTGKLIDKINLPDFLKVYLNHKPPFGNTMSGIHKSFEVLGYTNSKGKKAIRREDFLRLLVTKGEHMTEEEMLDCFASLFGLNPEGWKSEPATCSVKGSEICLEEELPDEITAEIFATEILGLTISEDSGQ 1146          

Query:  571 QDKN-PVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSD------KKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISV-GEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQ 3285
            +DK+ PV  LT  +S G+N  +P+  +  + +  + Y C+H  IIY+ + N Q  LQGH N ISC   S+D+RW+ T D+G + +VIIWD  TG+PV T+F+  P  +G+ A+++T DA+YLAT+S    Q   IW WT   + P C+  L T YG+QNY++FN  +  ++ +NS+T  ++Y W ++   L + AP LT++ FNK +GKF  ++F    T+ LSAT +G LVVW+     I  P  S S        K  KLV +  + ITVLT T S+IVTGD+ G+IKF+D+   ++ WY     G I ++S S + +        E S+YP D T++ + F + +FI+GT+ A    +T  G+K++ +F +   ++ ++  HP  PL+A GS  G++K+WNYE ++ + +R+F K + ++SL ++  G  +  GF  G + ILD  +L++   +PF +S+  +THI FS  S+++AT D +FT  +Y     N +  W Y+AR R+H K I  LLFG Y D+  PRL +LG DR L+ YDL  + +D L +L     +Q   P    WYP    E F++  N  YK+K++N  TKMCR + LGP +GSP++  + LP+    RS+ + +++RYL + NR+K+GL  +P++GNP+    ++ HP GV  +  S+DG+Y  +  G D  V  WKI L +LEA   LGG+ +TP+Y L+ GG  G F  EL++YFYYS +R+QGID+++ R V   I +SE+P++MRAIGFYPSEE+I+++ NE+KF +Y +TGK  DK++L  F+KVY+NH+P FG +   I ++F  +   +++G+ +I +  FL LL+ KGE + E ++ +  A+L G N EG   E    +       + E LP  +T + F   I+ + I +  SQ
Sbjct:  246 KDKSAPVYPLTMTWSFGWNSSLPVYYIREEKQRVLLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGSGIRAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTWAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSVFHLNLTQILSATMEGKLVVWD-----IHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLTTTDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPT----EKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSNEPRLLSLGTDRLLIGYDLLRSYKDCLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEQTQVLPV----RSMAE-LQKRYLVFINRDKVGLQILPVDGNPHKTSAIVCHPNGVAGMAVSYDGHYAFTAGGHDRSVVQWKITLSVLEAAVSLGGEDLTPFYGLLSGGREGKFYRELEDYFYYSQLRSQGIDTMETRKVSEHICLSELPFVMRAIGFYPSEEKIDDIFNEIKFGEYVDTGKLIDKINLPDFLKVYLNHKPPFGNTMSGIHKSFEVLGYTNSKGKKAIRREDFLRLLVTKGEHMTEEEMLDCFASLFGLNPEGWKSEPATSSVKGSEICLEEELPDEITAEIFATEILGLTISEYSSQ 1152          

Query:  469 KDTKIYISHSENHSPTPQRILSESKN-----FEQLPQISQDK-----------------------NPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFE--PHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQW-DKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDK-------KAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSK-IPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--IHNEGELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQV 3288
            KD  + +  +E  S  P+ IL++ K+      E+  ++ Q K                       + V  L+  +S G+N  +P+  +  D R  I Y+C+H  I+YD   N Q  LQGH N ISC   S+D+RW+ T D+G + ++IIWD  TG+PV T+F+  P  NG+ +I++T D+++LAT+S   TQ   IW WT   + P C+  L   YG Q+ + FN  +  ++ +NS+TQ ++Y W +  G L + AP LT++ FNK +GKF  ++F  K  + LSAT +G LVVW+     I  P+ ++S         K  KLV +  +AITVL    S+IVTGD+ G+IKF+D+   ++ WY ++  G I ++S S +          E S+ P D T++ + F + +FI+GT  A    +TV G+K++ +F +   +VY+V  HP  PL+A GS  G++K+W++E +  + +R F K + ++ L ++  G  +  GF  G + ILD  +L++   +PF +SK  ++H  FS  S ++AT D NFT  +Y     N +  W Y+AR R+H   I  LLFG + D+  PRL +LG+DR L+EY+L  + +D L +L   R +Q   P    WYP    E F++  N  YK+K++N  TKMCR + LGP +GSP++  + LP+ +        +++RYL + N++K+GL  +P++GNP+    ++ HP GV  +  S+DG +  + G +D  V  WKINL  LEA   LGG+ +TP+Y L+ GG  G F  EL++YFYYS IR+QGID+++ R V   I +SE+P++MRAIGFYPSEE+IE+M NE+KF +Y ETGK  DK++L  F+KVY+NHRP FG + + I+ +F  +   ++EG+ +I +  FLNLL+ KGE + E ++ +  +TL G   EG   E      +     + + LP+ +T + F   I+ + + D   Q+
Sbjct:  329 KDNSMKVDDTEEASQKPEDILAQGKDEARLSLEERRKLFQSKGLSAEESLVSVSTEDTLFQKEEDSKVYPLSMTWSFGWNSSLPVYYMREDRR-VILYTCAHTAIMYDVVRNTQYHLQGHPNIISCLCVSEDRRWIATADEGPDCLIIIWDSFTGIPVHTIFDSCPEGNGMRSIAITRDSKFLATISDSATQKVCIWKWTLAVETPACTLELPKEYGFQDNLVFNPANNKELVSNSKTQAIYYCWFEDKGILAHSAPVLTEKTFNKLVGKFSQSVFHLKLPQVLSATKEGKLVVWD-----IHYPSSTSSSAISAFPFIKPRKLVHLQKEAITVLMTIDSYIVTGDIKGNIKFYDHTLSVVNWYSNFKLGAIRTLSFSKTIP----SLPTEKSNLPTDCTLRGDLFVVRNFIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTFEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVAVYMVVVKNGQRVWEYLARLRSHQNSIQSLLFGVHLDSNEPRLLSLGKDRFLIEYNLVKSCKDHLDVLDVHRTDQGNYPTCMIWYPPLTKELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEHAQVLPVKSTLE-----LQKRYLVFINKDKVGLQILPVDGNPHKTCAIVCHPNGVAGMALSYDGRFAFTAGGQDRSVVQWKINLGALEAAVSLGGEDLTPFYGLVSGGREGKFYRELEDYFYYSQIRSQGIDTMETRQVSEHICLSELPFVMRAIGFYPSEEKIEDMFNEIKFSEYVETGKLIDKINLPDFLKVYLNHRPPFGNTMDGIQNSFNVLGYTNSEGKKAIRREDFLNLLLTKGEHMTEEEMIDCFSTLFGLTPEGWKSEPAATCINGPEICLQKELPEEITAEIFTTEILGLTLSDSSEQL 1297          

Query:  568 SQDKNPVSALTPVYSLGFNRYVP--IINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAE-----NTQTFAIWDWTTGEDVPLCSASLSTNY-GLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLK---YFAPKLTDQDFNKPIGK-FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKA-----------ITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATA--------IFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKT--RLF----SKIPIKSLCFDHH--GVQIAVGFANGELRILDT------HALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLY----RPGRNNV-EEPWVYVARYRAHYKKILDLLFGRYF---DTETPRLFTLGEDRRLVEYDL----YNASE---------DKLPILQETRIEQSAIPLTFCWYP-EENGEGFIVTANDQYKLKMYNHQT---KMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKI-GLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTI--------------------------IHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEE 3147
             +D + ++AL   ++LGFN  +   + NL+ + R  IFY  +H G+IYDY +N Q +LQGH N I+ T   K    + T D G +S++++WD +TG+P +T+FEPHPNG  A+ ++ D +++ TLS E     + Q+ ++W+W   ++  L +          Q ++ FN DD  +  T  +T+++F  W + G  K   Y++P       N P  K    T+F+P  T+ ++ T+ G ++VW+  +SLI    ++  +++A+KLV + +K+           I +L +  +++V G   G I+F+D+ Y ++ W++D   G IS+IS + +  +E  +      D  +D      KF   DFIV    A        +F  +  +  K   + +     + ++   P   ++     +G L  WN++ + S+ +  R+F      IP    C D+   G  ++V   +G++ I D       +++ +V        KV++    FS  S+ LAT+D ++  +L+    R    N+ E+ W +V ++R H+ +I  + FG      D +  RLF++G D ++VEY++    Y+  +         D+L +     IEQ  IP    WYP     E  ++T N+++K+K++       K C+ + LGP +G  +  L  L    N     ++ + +YLAY+ + K+ G+I++PL GNP   M +IAHP  +TS+ CS DG +  S G +D+ V VW +N+  LE  +    +   PY +L+EGGE G    +LK +FYYS IR++   + + R +D  + +  +P +MR++G+YP+ +EIENM NE++F  Y + G+  +++DLN F+K++VNHRP  GI   KI E+  T+                          I   GE+S+     +L  +GE++   +  E L  L G NE+
Sbjct:   14 QEDVSKINALNLKWTLGFNFQLTDGVHNLTNEKRKEIFYPVAHTGVIYDYENNTQRLLQGHCNRITATAYCKFSDIIVTADCGPDSMLVVWDASTGIPKKTIFEPHPNGCQALDISQDGQFIVTLSKEANTDTDVQSLSLWEWNKDDEPCLITNEFDRRIKDYQYFVRFNSDDNTEFATTGKTRIVF--WRREGEQKGFNYYSPG------NIPSLKVLTQTVFIPDNTQVVTGTTDGHIIVWD--ISLIIEKVDTPKERRAIKLVDLMNKSKKPDGKKGSNSINILKIQDNYLVIGSSNGSIRFYDFQYRIIAWFEDAIIGSISNISFANTPMIEDNEDEDGFDDERKDKGENEPKFICPDFIVVDLDATITMLNYKLFEELDDEKKKGTTLMKSIVSPIIAMSCRPNSNVIGICCENGYLYEWNFQEKSSVLSILRVFDTDKENIP---NCIDYSPDGNWLSVATKSGKIHIFDCKEKQWQNSVLEVSENEQGKPKVNMQ--VFSSDSKNLATMDADYAVSLFTIDHRQFDVNIPEKEWQFVGKHRIHHSEIKSIAFGESKNENDKKYYRLFSIGADMKMVEYEVLEIDYSKQKEKGQQINYIDRLKLKSIYPIEQETIPTACIWYPINMYKEDVLLTVNEEFKIKLWQFMKDNFKFCKKTCLGPIYGGAINKLLIL----NQNDAQNDYQDKYLAYSTKEKVVGIIKLPLEGNPNQTMGLIAHPDKITSISCSNDGKHFFSSGSDDYCVNVWSVNVQALEQIFATNPN-EDPYPKLLEGGEDGQTHQDLKNFFYYSQIRSKDEHTTKARKLDGKVPLIAIPDMMRSMGYYPTNKEIENMQNEIRFSKYLDPGEQVEELDLNMFLKLFVNHRPVQGIGKSKIAESLNTLTKSLSDSAKEIAEQAKGQSVQPKTYNIDGIGEISLQDLKKILTTEGERMTNEEFDECLKILCGENED 951          

Query:  589 SALTPVYSLGFNRYVP--IINLS---TDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENT----QTFAIWDWTT------------GEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIG-NLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQS----------VYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYR--PGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNAS 2181
            +AL+  +  G + +V   ++NLS   TD  C++    ++  +IYD     QL LQGHT+ I+C   ++D+  + T D G  +++++W+  TGLP RT+ +PH +GV  + ++ D ++LAT+SA +     Q  ++W                G   PL + +L     +Q+ I F+ ++  ++ +N   +V F+ W       +Y++P L  +DF + +G F  ++F+P TT+AL+AT+ G LVVW+      +V   S +D++A+KL+ +H+  IT+L   G FIV+G   G ++FFD    ++ W++D   GP++S+             +L +     D     N+F + DF+V T  +    V+V+ +  +    D  +           V  + AHPT    A     G L+ W+      +  R F +     L +   G  + VGF +G L IL+     D+       +   +  +  S   + +A  D N    LY   P ++ +   W YV R R+H+  I  ++FG     +T RL ++G D R+VEYDL  +S
Sbjct:    6 TALSLSWVFGASAHVKHGVVNLSDGYTDKICYL---AANTAVIYDKRLRRQLFLQGHTSPITCIVTTEDRSHVVTADTGPEALLVVWNVRTGLPTRTVQQPHRHGVSTMDMSADGQWLATVSAADPESGEQEVSLWSMAALLTPPEAAPPGQGPLRPLVT-TLVPAGDVQHSIRFSPNNPAELISNGRRRVYFWSWAPGSPRFQYYSPPLRSRDFKQSVGDFVSSVFVPGTTQALTATTDGDLVVWDEQGIAAQV-GTSATDRRAIKLMRIHNCPITLLATVGDFIVSGGEDGYVRFFDPLLRIVAWFEDLAAGPVTSV---------AFSAVLPDRLAHADAADTLNRFMVPDFVVATRNSRI--VSVQSASFEEYDADRRRGSSVLDSLLADVVDLAAHPTRAEFAVLGRDGGLQRWDSIAHCLLGGRAFERQVGACLTYSRDGSLLVVGFGSGHLHILNADDCSDLYV--MRNTAAGLVRVAVSNTGKHIAAADENHQLLLYAYLPYKHTMR--WEYVGRCRSHHGPIASVVFGESPSGQT-RLLSVGGDGRVVEYDLAASS 549          

Query: 2572 NYLISVGEDFIVTVWKINLDILEAQYQLG-GDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGE-------LSIDKFLNLLMNKGEKIN 3096
             +L+  G D  V  W IN   LE       G G    +  + G    + + E+++YF Y+ I+TQG D+L+ R V   + +  VP +MR+ GFYPSE +I+N+L+ +++  +    +  + V L   + +Y+NHRP F ++   I   FR  +   G+       LS ++ L+LL + GE ++
Sbjct:  588 THLLVSGADGTVASWDINTAPLERSATAAEGAGGEARWAAVLGDP--DLLREMRDYFVYAQIKTQGEDALEPRDVPGTVPVDLVPDLMRSAGFYPSESDIDNLLHHVQYMAHSRNMESLEVVTLADLLCLYINHRPLFNVTHADIVAAFRE-LGGRGDPGSCVPKLSREQLLSLLQSTGEPMS 767          

Query:  595 LTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKI-------KFILENSD-----YPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF----SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEG-ELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIV--DRESQVAYPTKSNNTLANSTQ 3333
            L PV++ G NR+VP+I+L+T  R  +FY+C++  ++YD   N+Q IL+GHTN+I+CT AS DKRWL TGD G +S VIIWD  T +PVRTMFEPHPNGV A++L  ++R+L TLSAE  QTFAIW+WTTGE++ LCSA+LS+ YG+Q YISFN DD   V TNS+ QVLF+QW + G ++YFAP LTD+DFNKP+G++CH++FL K+T+A+SATSQGL VVW+ N  L K+  E+T DK+AVKLVP+H+K ITVLT T   IVTGD  G +KFFD N  L++WYQ + FGP+SSIS    +   +        +  L++       Y  D TI +N F + DF++GT++A+FA V VK S+  +I RD D +V ++  HPT+  +A G  SG LKIWNY+T+ +  +R      S   I+ + FD  G  +AVG   G LRILD   L DV+ + FH+S+  ITHI FS+ S +LAT D  FTT+LY   R     PW YV R+RAHYK+I DLLFG   DT   RL +LG+DR LVEYD+ NAS+D LP++   RIEQ+ +PL   WYP    E F++TAND+YK K+YN  TK CR +FLGPT+GSPV+ +  LP    N    D   RRY  +   +KIGL  +PL+GNPYN +  +AHP+GV ++ CS DG +L + G ED  V +W ++  +L+AQ +LGG  + P+Y L+EGG  G    EL++YFYY+ +R QGIDS++ R V   I I+E+P++MR +GFYPSE+EI+NM+NE+KF  Y +TG+Y   +DL  FI++YVNHRP FG+S ++I + F+ +   +G E  +D+   L+LL N GE + E +LAEYL TLLGFN EGGS E+E+FNP      ++  +P  +    F+E+++    V   ++S  A  ++S +    S Q
Sbjct:  248 LKPVWAFGMNRHVPVISLATSERDVVFYACANSAVLYDVNANKQRILRGHTNAITCTAASNDKRWLVTGDAGLDSAVIIWDSRTAVPVRTMFEPHPNGVYAVALNPNSRFLCTLSAEANQTFAIWNWTTGEELSLCSATLSSAYGIQRYISFNADDNSHVVTNSDHQVLFFQWGE-GKVEYFAPPLTDKDFNKPVGRYCHSVFLRKSTKAISATSQGLCVVWDSNKPLTKMSTEATPDKRAVKLVPLHEKGITVLTQTDEIIVTGDTAGHVKFFDQNLQLLYWYQHFKFGPVSSISFKYQSLPAQTGAANDDDRLSLKSQPTMDPLYDTDATIPANPFFVRDFVIGTSSAVFANVDVKESRAHIIHRDFDAAVRAIDVHPTMTKIAIGGKSGYLKIWNYQTKLTECSRHIEGKASSSAIRCIKFDPAGEFLAVGHEGGLLRILDADTLSDVMEENFHYSRDCITHIVFSDDSRYLATADKEFTTSLYERERG---RPWTYVGRHRAHYKEIHDLLFGVQIDTGYNRLLSLGKDRYLVEYDIPNASKDNLPVMTSDRIEQNGVPLCMTWYPPIVKEQFLLTANDEYKYKLYNCTTKKCRNTFLGPTYGSPVRKICILP--HPNAQPTD---RRYAVFMLNDKIGLTILPLDGNPYNSVGCVAHPQGVANMACSADGRFLFTAGGEDATVQMWSVHPAVLDAQSKLGGPDLIPFYSLMEGGREGELFKELEDYFYYAQLRAQGIDSMETRWVSERIPIAEIPFVMRGLGFYPSEQEIDNMMNEIKFSRYVDTGEYVTDIDLGEFIRLYVNHRPVFGLSLDRIFKAFKVLGEAKGEEFLVDRGDILDLLQNSGEHMTEYELAEYLTTLLGFNPEGGSFELEEFNPATAGDLIDAHIPARIGASGFVEDLLGFGPVAARQKSSQAAGSRSQSARPKSVQ 1173          

Query:  595 LTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKI-------KFILENSD-----YPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF----SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEG-ELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIV--DRESQVAYPTKSNNTLANSTQ 3333
            L PV++ G NR+VP+I+L+T  R  +FY+C++  ++YD   N Q IL+GHTN+I+CT AS DKRWL TGD G +S VIIWD  T +PVRTMFEPHPNGV A++L  ++R+L TLSAE  QTFAIW+WTTGE++ LCSA+LS+ YG+Q YISFN DD   V TNS+ QVLF+QW + G ++YFAP LTD+DFNKP+G++CH++FL K+T+A+SATSQGL VVW+ N  L K+  E+T DK+AVKLVP+H+K ITVLT T   IVTGD  G +KFFD N  L++WYQ + FGP+SSIS    +   +        +  L++       Y  D TI +N F + DF++GT++A+FA V V+ S+  +I RD D +V ++  HPT+  +A G  SG LKIWNY+T+ +  +R      S   I+ + FD  G  +AVG   G LRILD   L DV+ + FH+S+  ITHI FS+ S +LAT D  FTT+LY   R     PW YV R+RAHYK+I DLLFG   DT   RL +LG+DR LVEYD+ NAS+D LP+L   RIEQ+ +PL   WYP    E F++TAND+YK K+YN  TK CR +FLGPT+GSPV+ +  LP    N    D   RRY  +   +KIGL  +PL+GNPYN +  +AHP+GV ++ CS DG +L + G ED  V +W ++  +L+AQ +LGG  + P+Y L+EGG  G    EL++YFYY+ +R QGIDS++ R V   I I+E+P++MR +GFYPSE+EI+NM+NE+KF  Y +TG+Y   +DL  FI++YVNHRP FG+S ++I + F+ +   +G E  +D+   L+LL N GE + E +LAEYL TLLGFN EGGS E+E+FNP      ++  +P  +    F+E+++    V   ++S  A  ++S +    S Q
Sbjct:  224 LKPVWAFGMNRHVPVISLATSERDVVFYACANSAVLYDVNANRQRILRGHTNAITCTAASNDKRWLVTGDAGLDSAVIIWDSRTAVPVRTMFEPHPNGVYAVALNPNSRFLCTLSAEANQTFAIWNWTTGEELSLCSATLSSAYGIQRYISFNADDNSHVVTNSDHQVLFFQWGE-GKVEYFAPPLTDKDFNKPVGRYCHSVFLRKSTKAISATSQGLCVVWDSNKPLTKMSTEATPDKRAVKLVPLHEKGITVLTQTDEIIVTGDTAGHVKFFDQNLQLLYWYQHFKFGPVSSISFKYQSLPAQTGAANDDDRLSLKSQPTMDPLYDTDATIPANPFFVRDFVIGTSSAVFANVDVRESRAHIIHRDFDAAVRAIDVHPTMTKIAIGGKSGYLKIWNYQTKLTECSRHIEGKASFSAIRCIKFDPAGEFLAVGHEGGLLRILDADTLSDVMEENFHYSRECITHIVFSDDSRYLATADKEFTTSLYERERG---RPWTYVGRHRAHYKEIHDLLFGVQIDTGYNRLLSLGKDRYLVEYDIPNASKDNLPVLTSDRIEQNGVPLCMTWYPPIVKEQFLLTANDEYKYKLYNCTTKKCRNTFLGPTYGSPVRKICILP--HPNAQPTD---RRYAVFMLNDKIGLTILPLDGNPYNSVGCVAHPQGVANMACSADGRFLFTAGGEDATVQMWSVHPAVLDAQSKLGGPDLIPFYSLLEGGREGELFKELEDYFYYAQLRAQGIDSMETRWVSERIPIAEIPFVMRGLGFYPSEQEIDNMMNEIKFSRYVDTGEYVTDIDLGEFIRLYVNHRPVFGLSLDRIFKAFKVLGEAKGEEFLVDRGDILDLLQNSGEHMTEYELAEYLTTLLGFNPEGGSFELEEFNPATAGDLIDAHIPARIGASGFVEDLLGFGPVAARQKSSQAAGSRSQSARPKSVQ 1149          

Query:  595 LTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKI-------KFILENSD-----YPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF----SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEG-ELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIV--DRESQVAYPTKSNNTLANSTQ 3333
            L PV++ G NR+VP+I+L+T  R  +FY+C++  ++YD   N Q IL+GHTN+I+CT AS DKRWL TGD G +S VIIWD  T +PVRTMFEPHPNGV A++L  ++R+L TLSAE  QTFAIW+WTTGE++ LCSA+LS+ YG+Q YISFN DD   V TNS+ QVLF+QW + G ++YFAP LTD+DFNKP+G++CH++FL K+T+A+SATSQGL VVW+ N  L K+  E+T DK+AVKLVP+H+K ITVLT T   IVTGD  G +KFFD N  L++WYQ + FGP+SSIS    +   +        +  L++       Y  D TI +N F + DF++GT++A+FA V V+ S+  +I RD D +V ++  HPT+  +A G  SG LKIWNY+T+ +  +R      S   I+ + FD  G  +AVG   G LRILD   L DV+ + FH+S+  ITHI FS+ S +LAT D  FTT+LY   R     PW YV R+RAHYK+I DLLFG   DT   RL +LG+DR LVEYD+ NAS+D LP+L   RIEQ+ +PL   WYP    E F++TAND+YK K+YN  TK CR +FLGPT+GSPV+ +  LP    N    D   RRY  +   +KIGL  +PL+GNPYN +  +AHP+GV ++ CS DG +L + G ED  V +W ++  +L+AQ +LGG  + P+Y L+EGG  G    EL++YFYY+ +R QGIDS++ R V   I I+E+P++MR +GFYPSE+EI+NM+NE+KF  Y +TG+Y   +DL  FI++YVNHRP FG+S ++I + F+ +   +G E  +D+   L+LL N GE + E +LAEYL TLLGFN EGGS E+E+FNP      ++  +P  +    F+E+++    V   ++S  A  ++S +    S Q
Sbjct:  144 LKPVWAFGMNRHVPVISLATSERDVVFYACANSAVLYDVNANRQRILRGHTNAITCTAASNDKRWLVTGDAGLDSAVIIWDSRTAVPVRTMFEPHPNGVYAVALNPNSRFLCTLSAEANQTFAIWNWTTGEELSLCSATLSSAYGIQRYISFNADDNSHVVTNSDHQVLFFQWGE-GKVEYFAPPLTDKDFNKPVGRYCHSVFLRKSTKAISATSQGLCVVWDSNKPLTKMSTEATPDKRAVKLVPLHEKGITVLTQTDEIIVTGDTAGHVKFFDQNLQLLYWYQHFKFGPVSSISFKYQSLPAQTGAANDDDRLSLKSQPTMDPLYDTDATIPANPFFVRDFVIGTSSAVFANVDVRESRAHIIHRDFDAAVRAIDVHPTMTKIAIGGKSGYLKIWNYQTKLTECSRHIEGKASFSAIRCIKFDPAGEFLAVGHEGGLLRILDADTLSDVMEENFHYSRECITHIVFSDDSRYLATADKEFTTSLYERERG---RPWTYVGRHRAHYKEIHDLLFGVQIDTGYNRLLSLGKDRYLVEYDIPNASKDNLPVLTSDRIEQNGVPLCMTWYPPIVKEQFLLTANDEYKYKLYNCTTKKCRNTFLGPTYGSPVRKICILP--HPNAQPTD---RRYAVFMLNDKIGLTILPLDGNPYNSVGCVAHPQGVANMACSADGRFLFTAGGEDATVQMWSVHPAVLDAQSKLGGPDLIPFYSLLEGGREGELFKELEDYFYYAQLRAQGIDSMETRWVSERIPIAEIPFVMRGLGFYPSEQEIDNMMNEIKFSRYVDTGEYVTDIDLGEFIRLYVNHRPVFGLSLDRIFKAFKVLGEAKGEEFLVDRGDILDLLQNSGEHMTEYELAEYLTTLLGFNPEGGSFELEEFNPATAGDLIDAHIPARIGASGFVEDLLGFGPVAARQKSSQAAGSRSQSARPKSVQ 1069          

Query:  595 LTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKI-------KFILENSD-----YPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF----SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEG-ELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIV--DRESQVAYPTKSNNTLANSTQ 3333
            L PV++ G NR+VP+I+L+T  R  +FY+C++  ++YD   N Q IL+GHTN+I+CT AS DKRWL TGD G +S VIIWD  T +PVRTMFEPHPNGV A++L  ++R+L TLSAE  QTFAIW+WTTGE++ LCSA+LS+ YG+Q YISFN DD   V TNS+ QVLF+QW + G ++YFAP LTD+DFNKP+G++CH++FL K+T+A+SATSQGL VVW+ N  L K+  E+T DK+AVKLVP+H+K ITVLT T   IVTGD  G +KFFD N  L++WYQ + FGP+SSIS    +   +        +  L++       Y  D TI +N F + DF++GT++A+FA V V+ S+  +I RD D +V ++  HPT+  +A G  SG LKIWNY+T+ +  +R      S   I+ + FD  G  +AVG   G LRILD   L DV+ + FH+S+  ITHI FS+ S +LAT D  FTT+LY   R     PW YV R+RAHYK+I DLLFG   DT   RL +LG+DR LVEYD+ NAS+D LP++   RIEQ+ +PL   WYP    E F++TAND+YK K+YN  TK CR +FLGPT+GSPV+ +  LP    N    D   RRY  +   +KIGL  +PL+GNPYN +  +AHP+GV ++ CS DG +L + G ED  V +W ++  +L+AQ +LGG  + P+Y L+EGG  G    EL++YFYY+ +R QGIDS++ R V   I I+E+P++MR +GFYPSE+EI+NM+NE+KF  Y +TG+Y   +DL  FI++YVNHRP FG+S ++I + F+ +   +G E  +D+   L+LL N GE + E +LAEYL TLLGFN EGGS E+E+FNP      ++  +P  +    F+E+++    V   ++S  A  ++S +    S Q
Sbjct:  297 LKPVWAFGMNRHVPVISLATSERDVVFYACANSAVLYDVNANRQRILRGHTNAITCTAASNDKRWLVTGDAGLDSAVIIWDSRTAVPVRTMFEPHPNGVYAVALNPNSRFLCTLSAEANQTFAIWNWTTGEELSLCSATLSSAYGIQRYISFNADDNSHVVTNSDHQVLFFQWGE-GKVEYFAPPLTDKDFNKPVGRYCHSVFLHKSTKAISATSQGLCVVWDSNKPLTKMSTEATPDKRAVKLVPLHEKGITVLTQTDEIIVTGDTAGHVKFFDQNLQLLYWYQHFKFGPVSSISFKYQSLPAQTGAANDDDRLSLKSQPTMDPLYDTDATIPANPFFVRDFVIGTSSAVFANVDVRESRAHIIHRDFDAAVRAIDVHPTMTKIAIGGKSGYLKIWNYQTKLTECSRHIEGKASSSAIRCIKFDPAGEFLAVGHEGGLLRILDADTLSDVMEENFHYSRDCITHIVFSDDSRYLATADKEFTTSLYERERG---RPWTYVGRHRAHYKEIHDLLFGVQIDTGYNRLLSLGKDRYLVEYDIPNASKDNLPVMTSDRIEQNGVPLCMTWYPPIVKEQFLLTANDEYKYKLYNCTTKKCRNTFLGPTYGSPVRKICILP--HPNAQPTD---RRYAVFMLNDKIGLTILPLDGNPYNSVGCVAHPQGVANMACSADGRFLFTAGGEDATVQMWSVHPAVLDAQSKLGGPDLIPFYSLMEGGREGELFKELEDYFYYAQLRAQGIDSMETRWVSERIPIAEIPFVMRGLGFYPSEQEIDNMMNEIKFSRYVDTGEYVTDIDLGEFIRLYVNHRPIFGLSLDRIFKAFKVLGEAKGEEFLVDRGDILDLLQNSGEHMTEYELAEYLTTLLGFNPEGGSFELEEFNPATAGDLIDAHIPARIGASGFVEDLLGFGPVAARQKSSQAAGSRSQSARPKSVQ 1222          

Query:  595 LTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKI-------KFILENSD-----YPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF----SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEG-ELSIDK--FLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIV--DRESQVAYPTKSNNTLANSTQ 3333
            L PV++ G NR+VP+I+L+T  R  +FY+C++  ++YD   N Q IL+GHTN+I+CT AS DKRWL TGD G +S VIIWD  T +PVRTMFEPHPNGV A++L  ++R+L TLSAE  QTFAIW+WTTGE++ LCSA+LS+ YG+Q YISFN DD   V TNS+ QVLF+QW + G ++YFAP LTD+DFNKP+G++CH++FL K+T+A+SATSQGL VVW+ N  L K+  E+T DK+AVKLVP+H+K ITVLT T   IVTGD  G +KFFD N  L++WYQ + FGP+SSIS    +   +        +  L++       Y  D TI +N F + DF++GT++A+FA V V+ S+  +I RD D +V ++  HPT+  +A G  SG LKIWNY+T+ +  +R      S   I+ + FD  G  +AVG   G LRILD   L DV+ + FH+S+  ITHI FS+ S +LAT D  FTT+LY   R     PW YV R+RAHYK+I DLLFG   DT   RL +LG+DR LVEYD+ NAS+D LP++   RIEQ+ +PL   WYP    E F++TAND+YK K+YN  TK CR +FLGPT+GSPV+ +  LP    N    D   RRY  +   +KIGL  +PL+GNPYN +  +AHP+GV ++ CS DG +L + G ED  V +W ++  +L+AQ +LGG  + P+Y L+EGG  G    EL++YFYY+ +R QGIDS++ R V   I I+E+P++MR +GFYPSE+EI+NM+NE+KF  Y +TG+Y   +DL  FI++YVNHRP FG+S ++I + F+ +   +G E  +D+   L+LL N GE + E +LAEYL TLLGFN EGGS E+E+FNP      ++  +P  +    F+E+++    V   ++S  A  ++S +    S Q
Sbjct:  159 LKPVWAFGMNRHVPVISLATSERDVVFYACANSAVLYDVNANRQRILRGHTNAITCTAASNDKRWLVTGDAGLDSAVIIWDSRTAVPVRTMFEPHPNGVYAVALNPNSRFLCTLSAEANQTFAIWNWTTGEELSLCSATLSSAYGIQRYISFNADDNSHVVTNSDHQVLFFQWGE-GKVEYFAPPLTDKDFNKPVGRYCHSVFLHKSTKAISATSQGLCVVWDSNKPLTKMSTEATPDKRAVKLVPLHEKGITVLTQTDEIIVTGDTAGHVKFFDQNLQLLYWYQHFKFGPVSSISFKYQSLPAQTGAANDDDRLSLKSQPTMDPLYDTDATIPANPFFVRDFVIGTSSAVFANVDVRESRAHIIHRDFDAAVRAIDVHPTMTKIAIGGKSGYLKIWNYQTKLTECSRHIEGKASSSAIRCIKFDPAGEFLAVGHEGGLLRILDADTLSDVMEENFHYSRDCITHIVFSDDSRYLATADKEFTTSLYERERG---RPWTYVGRHRAHYKEIHDLLFGVQIDTGYNRLLSLGKDRYLVEYDIPNASKDNLPVMTSDRIEQNGVPLCMTWYPPIVKEQFLLTANDEYKYKLYNCTTKKCRNTFLGPTYGSPVRKICILP--HPNAQPTD---RRYAVFMLNDKIGLTILPLDGNPYNSVGCVAHPQGVANMACSADGRFLFTAGGEDATVQMWSVHPAVLDAQSKLGGPDLIPFYSLMEGGREGELFKELEDYFYYAQLRAQGIDSMETRWVSERIPIAEIPFVMRGLGFYPSEQEIDNMMNEIKFSRYVDTGEYVTDIDLGEFIRLYVNHRPIFGLSLDRIFKAFKVLGEAKGEEFLVDRGDILDLLQNSGEHMTEYELAEYLTTLLGFNPEGGSFELEEFNPATAGDLIDAHIPARIGASGFVEDLLGFGPVAARQKSSQAAGSRSQSARPKSVQ 1084          

Query:  508 SPTPQRIL---SESKNFEQLPQISQDKNP--VSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDK----KAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYP-----EDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF-SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVK-ILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGE-DFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAF---GISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKIN 3096
            SP P  +    S+     QLP I++ +N      LT  ++ G N  VP+ +L  ++R  + YSCSH+ +IYD+  N Q +LQGH + ISC   S+D+RW+ T D+G+ S+VIIWD  TG+PVRT+FE HP  GV A++L+ D++YL T+ A   Q   IWDWT   + P C   +   +G QN+I+FN  D FQ+ +NSE  VLFY W                 F+K +G    + F     +A S +  G +V+W+       V   S +DK    +A KL+ + +  I+ LTL  SFIVTGDV G +KF+D ++ L+ WY ++N  P           +  I F  E +        ED ++ +      +F++ T +A    V V+GS  + + ++H +S+ +V  HP  PLVA G +SGLLK+W+YE +  + +R+F +   I+ + +D  G  +A+GFA+G ++ILD   L+    + F +S   ITH+ FS  S +LAT D     T+++  +   + P             I DL+FG   D+  PRL +LG D +LVEYDL N+ +D+L IL   RIEQSA P    WYP    E F++ A+D YKLKM+N  TKMCR + LGPT+GSP+K +L  LP    + S       RY+AY  ++K+G+  +PL+GNPY    +I H  GV+S+ CS+DG Y+ + G  D  V  W+I+L  LEA   LGG  M P+Y L+EGG  G     ++++FYY  +R QG DS++ R V   I ++EVP+I+RA+GFYP+E+E+E+M NE+KF  Y ETG Y   +DL  FIK+Y+NHRPAF   G+  E            +  +S ++ L  L N+G  I+
Sbjct:   57 SPKPGHLQPQDSQVYTATQLPFINKKENSDKTHPLTLDWAFGINPAVPVFSLVDEDRLAVLYSCSHVAVIYDHTSNSQHLLQGHCSPISCLCVSEDRRWIVTADKGQESLVIIWDSYTGIPVRTLFESHPEGGVAALALSKDSKYLGTVGAGAVQRVCIWDWTNETEGPECQVEIHPEHGFQNHITFNTTDSFQLVSNSEGHVLFYTW-------------VSTTFSKVVGPISQSTFFSSGVQACSVSLAGNVVLWD-------VVEGSAADKNREMQATKLITLQNDGISALTLCDSFIVTGDVNGHVKFYDESFKLINWYSEFNLDP-----------ISSISFSKEITSSSSVRNQEDCSLNNQPLIKRNFVLSTVSAALVHVNVQGSVAQSLLKEHVESLDAVACHPKHPLVAMGGHSGLLKVWDYEKKTVVFSRVFNTDKQIQCMAYDPQGFYLALGFASGTVQILDACTLQQEQEESFQYSLECITHLTFSHDSSYLATADSGKAVTVFQLCKKGGQHP-------------IQDLMFGVQLDSTQPRLLSLGMDCKLVEYDLQNSRKDELLILSLDRIEQSAHPTCMAWYPPLTTEHFLLIASDHYKLKMFNVTTKMCRKTLLGPTYGSPLKKMLILLPCKDKDPS------SRYMAYITKDKVGVQILPLDGNPYKSSALICHSMGVSSMDCSYDGRYIFTAGGIDKTVFSWEISLLALEAAASLGGQDMIPFYTLLEGGRDGELFRVMEDFFYYCQLRNQGSDSMETRQVSTHIPLTEVPFIVRALGFYPTEQELEDMQNEVKFSCYAETGNYVTDIDLEDFIKLYINHRPAFLELGVPDES----------GQPAVSREELLEFLQNRGNFIS 880          

Query:  571 QDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGK----------FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATVDGNFTTTLY 2007
            +++ P S     +  G+  Y    NL       I Y  + +G++Y+   N Q    GH + I C      K ++ TG  G +S + +W+     P+  +   H  GV  +  + D + LA++  ++  T  +WDW  GE        LS   G +       D IF V  N       Y  DK+        K   +     IGK           C  ++        S T  G + +W               D   VK V  HD  +  +       VTG   G +  +D  +      + +          S    LE            ++ +I++        +VGT       V  K   I ++ + H +  V+ +  HP LPL AT S    L+IW+      +      K   +  CF   G  +AVG  +G   I++   L+D++S  FH  K  I+ I+FS  + ++LA   G+    +Y
Sbjct:  676 RERAPASGARLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDSSIHVWETEFLKPLSVLKGFHQFGVCTLDFSADGKRLASVGLDDNHTIVLWDWRKGE-------KLSAFRGSK-------DKIFVVKINP------YMPDKLITAGVKHMKFWHKAGGGLIGKKGSMGKTETMMC-AVYGWTEEMVFSGTCTGDICIWR--------------DMFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDTFERCL--KTYAIKRSVLAPGSKGLLLE------------DNPSIRAISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLATHPHLPLCATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLIVNADTLEDLVS--FHHRKDIISDIRFSPGAGKYLAVASGDSFVDIY 1114          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTR---ALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGE---LRILDT-------------HALK-----------------DVLSKPFHFSKVH--------ITHIQFSEKSEFLATVDGNFTTTLYR 2010
            I Y  + +G++Y+   ++Q    GH + I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  +D + L ++  ++  T  +WDW  G+        L+   G  + I     D++Q +      V   + W   GN     PK   +      G+   T+      R     S    G + VW+G V+LI+             +   H   I  +        TG   G I+ +D            +F PI+            +  + E     +  +++S  +     +VGT  + IF  V    +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+       G+ +++G  +G    LR+ D              H LK                 D+ S    + KV         ITH+ +S  S++L T DG+     YR
Sbjct:   36 IVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILKDTHTHGIACLAFDLDGQCLVSVGLDSKNTICVWDWRRGK-------VLAAAPGHTDRIFDISWDLYQQSKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGRTGEL-QTILCVACARDEVTYSGALNGDIYVWKG-VNLIRT------------IQGAHGSGIFSMNACEEGFATGGRDGCIRLWDL-----------SFKPIT------------VIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEVVVHDRTKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSL-IDHALIARCNMEEPIRCAAVSTDGIHLSLGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGSHLAVGSNDNSVDIYSVVQRYKKVGECVGSLSFITHMDWSTDSKYLQTNDGSGKRLFYR 479          

Query:  550 EQLPQISQ--------DKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDK-----IGNLKYFAPKLTDQDFNKPI----GK---FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATVDGNFTTTLY 2007
            E LPQ+ +         K P   L   +  G+       NL       + Y  + +G++Y+   + Q    GH + I   TA   K ++ TG  G +  + +WD  T   +  +   H  GV A+  T D + L ++  +   +  +WDW  GE        L+   G +       D IF V  N       ++ DK     I ++K++        F + I    GK        +        S  + G + +W+              D   +K +  HD  +  +       VTG   G ++ +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       +   G    ++    +  V+ + AHP LP+ AT S    L+IW       +      K   +   F   G  +AVG  +G   +++   L+D+++  FH  K  I+ ++FS+ + ++LA    +    +Y
Sbjct:  647 EDLPQLKKKLVGSLKRQKAPDEGLRLQFVHGYRGCDCRNNLFYTQTGEVVYHVAAVGVVYNRQQHTQRFYLGHDDDILSLTAHPLKDYVATGQVGRDPAIHVWDIQTLKCLSLLRGQHQRGVCALEFTADGKSLVSVGIDEGHSIVMWDWKKGE-------KLAKARGHK-------DKIFVVKGNP------FRMDKLVTVGIKHIKFWQHTGGGLTFKRGIFGNLGKQETMMSACYGRSEDLVFSGATTGDVYIWK--------------DTSLIKTIKAHDGPVFAMCSLDKGFVTGGKDGIVELWDDMFERCLKTYAIKRAALSPSSK------------GLLLE-----DNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSANHRMVAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTLEDMVT--FHHRKEIISDLKFSQDAGKYLAVASHDSFVDIY 1103          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIF---QVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRAL--SATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDHDQS-VYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLY 2007
            I Y  + +G++Y+   + Q    GH + I       DK  + TG  G++  + +WD  T + V  + + H +GV  ++   D + L ++  +   T ++WDW  G         L+T  G  + I     D F   ++ +     + F  W   GN     PK   +      G     L L      +  S    G + VW+G ++L++    +            H   I  +        TG   G ++ +D            +F P           + KI        Y +  +I+S  +     + GT  + IF  +     K  ++ + H +  ++++  HP  P+  TGS    +++W+      I  R   +  ++S+ F++ G Q+A+G  +G   +L    + +V+        +H   ++FS    +LA    +    +Y
Sbjct:   36 IVYFVAGVGVVYNTREHSQKFYLGHNDDIISLALHPDKIQVATGQVGKDPYICVWDSYTLITVSILRDVHTHGVACLAFDADGQRLVSVGLDAKNTVSVWDWKKGR-------VLATATGHSDRIFDISWDPFLPHRLVSCGVKHIKF--WTLCGNA--LTPK---RGIFGKTGDLQTILCLATAKEEVTYSGALNGDIYVWKG-LNLVRTVQAA------------HGAGIFSMHACEEGFATGGRDGCVRLWDV-----------DFKP-----------ITKIDLREAEQGY-KGLSIRSVCWKADRILAGTQDSEIFEVMVRDRDKPLLVMQGHSEGELWALDLHPKQPIAVTGSDDRSVRLWSLADHTLI-ARCNMEEAVRSVSFNNDGSQLALGMKDGSFTVLRVRDMTEVVHIKDRKEVIH--ELKFSPDGSYLAVGSNDGLVDIY 435          

Query:  502 NHSPTPQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDV 993
            N    PQ         +Q+  + + + P +AL   +  G+  Y    NL       + Y  + +GI+Y+   + Q    GH + I   T    K +  TG  G +  V +WD  +   +  +   H  GV A+  + D + L ++  ++  T  +WDW  GE +
Sbjct:  613 NPEDLPQLKQQSRGRMQQVGSLKRQQPPDAALRLQFVHGYRGYDCRNNLFYTQTGEVVYHVAAVGIVYNRQQHTQRFYLGHDDDIISLTVHPIKDYAATGQVGRDPAVHVWDVQSLKCLSLLRGFHQRGVCALDFSADGKSLVSVGVDDNHTIIVWDWKKGEKL 776          

Query:  565 ISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGD---QGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTN---YGLQNYISFNCDDIFQVTTNSETQV 1098
            ++ ++  VS L     +GFN +V     S  +R  + Y      II +    +Q  L GHTN++SC T SK  R++ +G     G  + VI+WD  +   +      H   V A++ + + ++L TL  ++  +  +WD    E   +C +  ST+   + L    S + D+IF    N+  +V
Sbjct:    1 MAGEEQQVSKLELEAVIGFNGHVLSGLQSHPDREHVIYPLGCTLIIKNLNSGKQSFLHGHTNNVSCLTVSKSGRYIASGQVTFMGFKADVIVWD-YSKREIYAQLILHKVKVEALAFSPNEKFLVTLGGQDDGSIVVWDVEKKE--AICGSPASTDMAGHCLTVAFSSHSDNIFISAGNNTLRV 181          

Query:  604 VYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSD----KKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKV-IFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDV------LSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTE--------TPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNY-------MTMIAHPRG------VTSLCCSFDGNYLISVGE-DFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNE-GELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENII 3255
             +S+G N  V + +L    R  + Y+C    I++DY  + Q ILQGH N++SC   S++KRWL T D G  S VI+WD  +G+PV T+F  HP  GVVA++++ DA Y+ TL  E  Q  ++W WT   D+P+CS  L  ++G Q +++FN  D     TNSETQ +FYQW    +++ + P L +Q F + +G   H++F    +  LS T+ G LVVW         PN  T+     +KA+KL+ + D+ IT L L+  F+VTGD  G ++++D    L+FW Q    G  +  +    +   +    LE    P D ++++  F   +F+              GS   +  +   D +  ++ AHP  PLV   +  G + +W+ +T+  + +R F +  + SL +D  G ++A+GF++G   ++   +L D         +P H     +T + FS    +LAT D     +++          W  + R RAH + I D++F  + D +        +PRL +LGEDR LVEY L   S +++ +L   R+EQSA+PL   ++P  + E F++TAN+Q+K K+YN  T MCR + L P  GSP+K +  LP    N  I +  K  +L +   + +GL  +PL+GNP+++       M + +H RG      V  + CS DG+Y+++ G+ D  V VW++N   +     L G+G+ P+Y ++E G  G+F  EL++YFY++ +  QG+++L  R V   +D++ VP +MRA+G YP+++EIE +LNE++F  Y ETG++   ++L  F+ +Y+NHRP  G + + I +   T+  ++ G L   + L+ L+N GE++ E +LAE  ++L+         E+   N  +  + +  ALP+ VT + F E ++
Sbjct:    2 AWSIGVNSRVAVRSLQDAERNAVIYTCGRAVILFDYEKHTQHILQGHANTLSCMCLSENKRWLATADTGPGSTVIVWDTYSGIPVHTLFSCHPEKGVVAMTMSPDASYIITLGTETPQRVSVWRWTIESDLPVCSVELDPDWGYQTHVTFNISDHRHFITNSETQAVFYQWSD-NSIEMYTPVLNEQTFGRAVGPLTHSVF--SQSSVLSGTATGNLVVWSVPGC---APNVHTATHGAVRKALKLLHLQDRPITTLALSDQFVVTGDTTGTVRYYDLQLRLLFWLQ-IPHGVAAGHTVVCVSFSAEPGRPLEGQSPPRDASLEAAPFVAREFVASMR---------DGSVFNIKPYLYPDLATSALAAHPDRPLVCMATSRGTVILWDLDTQHDVASREF-RTSVSSLAYDQPGNRVAIGFSDGCTHVVCGLSLADETVEPLDCQRPEHHEAHAVTRLCFSHDGRYLATSDTTHAVSVFV---TVSASEWRLLGRQRAHSQAICDIVFEAHPDKQQDTQQDMHSPRLLSLGEDRILVEYSL---SSNEVSVLHFQRVEQSAVPLCLLFHPALSAETFLLTANNQHKYKLYNATTLMCRKTTLAPLLGSPLKKICALP----NTDITN--KAHFLVFITNDCVGLQMLPLDGNPHHWVGVHCHAMAVDSHMRGAVAGGGVQDVACSHDGHYVVTAGKADGAVHVWRVNTMAIHTASSLAGEGIVPFYSMLECGREGDFFRELEDYFYFAQLLRQGLETLDVREVCDRVDLAHVPSLMRALGHYPTQQEIEQILNEVRFAHYAETGEFVTSLNLPEFLCLYLNHRPVEGPTLKSIRDALTTLGGSQDGHLDRSQLLHALLNTGERMTEGELAECFSSLMSLKSPRQGDEVTLCNTVQSQEVLQMALPETVTPEGFTEQVL 891          

Query: 1663 HDQS-VYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFS-EKSEFLATVDGNFTTTLYR 2010
            H QS V+ + AHP LP+ A+ S    L++W+      +          +  CF   G  +AVG  +G   +++ + L+D+LS  F   +  IT I+FS +  ++LA    +    +YR
Sbjct:    9 HMQSEVWGLAAHPHLPICASVSDDKTLRVWDLSDNHCMLAVRKLNDSGRCCCFSSDGKALAVGLNDGSFLVVNANTLEDMLS--FQHRREMITDIKFSPDPGKYLAVASHDGFVDVYR 124          

Query:  613 LGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGD---QGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISF-NCDDIFQVTTNSETQVLFYQWD 1116
            +GFN  VP   +S  +   + Y      +I       Q  L GHTN++SC   S    ++ +G     G  + VI+W+      +      H   V A++ + +  YLA+L  ++  +  IW+ T  E V   + SL T  G  N + F N  D+  +T  ++T +  +Q D
Sbjct:   20 IGFNGQVPSGLVSHPDCEHLLYPLGCTVVIRSLKGARQSFLHGHTNNVSCLAVSNSGHYVASGQVTYMGFKADVILWNFEK-RELHARLTLHKVKVEALAFSPNDLYLASLGGQDDGSVVIWNVTKKEAVCGNAVSLPT-AGTTNTVRFTNTSDLSFITAGNDT-IRVWQLD 188          

Query: 1642 IKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLG-EDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILK-TLPI 2400
            IK  F +    V  +  HPT P V T  YSG +++WNYET+  +++   ++ P+++  F      I VG  +  +R+ + +  + V+   F     +I  I       ++ +   + T  L+     N E  W     +  H   ++ +     F+ + P  F  G  DR +  + L  ++    P    T  ++  +     +YP  + + +++TA+D   +K++++QTK C  +  G        +   TLPI
Sbjct:    5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVD--FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW-----NWENNWALEQTFEGHEHFVMCVA----FNPKDPSTFASGCLDRTVKVWSLGQST----PNFTLTTGQERGVNYV-DYYPLPD-KPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPI 242          

Query: 2041 VYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQ 2298
            +YV + RAHYK I D+ FG   D+  PRL ++G DR LVEYDL +++ D + +L   RIEQSA+P    WYP    E F+V ANDQ
Sbjct:   67 LYVGKQRAHYKSIADISFGVALDSTVPRLLSVGHDRVLVEYDLESSTTDDVRLLGSDRIEQSAVPQCLAWYPPIVKENFLVIANDQ 152          

Query:  565 ISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRAL--SATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGT-ATAIFATVTVKGSKIKVIFRDHDQS-VYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            +++   P S +   +  G+  +    NL       I Y  + +G++Y+   N Q    GH + I       +K  + TG  G++  + +WD ++   V  + + H  G+  ++      YL ++  E+     +WDW  G+ +          + +Q    FN      + +     ++F  W   GN     PK   +      G+    L L   +  +  S T  G +  W+G      +PN              H  A+  +        +G   G +  +D             F P           + K+  I     Y E  +I+S  +     +VGT A  +F  +     K + I + H +  ++++ AHP   + ATGS    +++W+   + S+  R      ++S+ F+  G  +AVG ++G   IL    L +V     +  K  +  +++S   +FLA
Sbjct:    1 MTERTAPSSQIRLEWVYGYRGHQCRNNLYYTASKEIVYFVAGVGVVYNTRENTQRFFLGHDDDIISLALHPEKVLVATGQVGKDPYICVWDSHSTETVSILKDAHQRGITCLAFNPSGNYLVSVGLEDYHMVVVWDWKRGKQLASTRGHTDRIFDMQ----FNPYKENVLVSCGVKHIIF--WTLRGN--SLNPK---KGIFGKTGEIQTNLCLAFGSDDVTYSGTLSGEIYKWKGQNLAGAIPN-------------AHTGAVFSIFGGADGFASGSKDGTVVLWDA-----------EFKP-----------IAKLDLINTRVGY-EGLSIRSVCWLGEKILVGTNAGEVFEVMATDKDKPRTIVQGHAEGELWALAAHPKKGIFATGSDDKSVRLWSMADK-SLLARTDVDQKVRSVAFNADGTHLAVGLSDGSFMILKARDLSEVTR--INDRKEVLHEMKYSPDGQFLA 424          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTG-------DQGENSVVIIWDCNTGLPVRTM-FEPHPNGV--VAISLTMDARYLATL-SAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNY---ISFNCDDIFQVTTNSETQVLFYQWDKIGNL--------KYFAPK-LTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVP--VHDKAITVLTL--TGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEF--LATVDGN-FTTTLYRPG 2016
            I Y  S + +IY+   N Q    GH + I C     ++ ++ TG       DQ E S + +WD  T + +  +  + +   V  +A S+  + + L  + S +++    +W+W   ED  L + S     G+Q     I+F+ DD   + +  +  + F++W   G L        KY  P+ LT  DF  P G  C            +  S G + VW G VS            K +K V    H+K+I  L +   G+ +  G V G +  +D N             P+        T   ++KF      + +D T+     A +  + G+ T+ F  + VKG         H   V ++  HP+  L  + S      +W+ +  ++  +       IK   F + G  +A+G   G   +LD      V S  F      +T I++S + E   +A+ DGN +  ++Y  G
Sbjct:   18 ILYFISRIVVIYNKKSNIQRHYTGHADDIKCMAVHPNQWYIATGQASGLSLDQNEMSHIRLWDAETLITLVVLPLDDYSLSVETLAFSVEDNGKQLVCIDSNDDSFRLNLWEW---EDRSLLTQS---KVGIQTPVLDIAFDPDDSKTIVSCGKEHIYFWRWHN-GKLERKNGYFEKYPVPQYLTCMDF-APNGDIC------------TGDSSGTVTVW-GKVS------------KKIKFVVRNAHEKSIFCLRVLPNGTLLTAGGVDGRVCAWDSNKYFT--------TPLHEAQVRQLTQQIRLKF------HSDDVTLLVGTTA-NKILEGSFTSDFIPL-VKG---------HSDEVPALAVHPSKDLFISASMDKFAYLWSAKDHKTAWSTDVG-FSIKCAAFYNTGSVVALGSTKGRWIVLDGQTGMHVCS--FQDGTEPLTDIEYSPEGEHVAIASKDGNIYVHSVYDDG 435          

Query:  613 LGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQ---GENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISF--NCDDIFQVTTNSETQV 1098
            +GF   VP   L   +R  + Y   +  +I      +Q  L GHT++++C   SK  R+L +G Q   G  + VI+WD      ++     H   V A++ + +  YL +L  ++  +  +WD   GE V    A++ +  G  N ++F  + D++F    N   +V
Sbjct:   18 IGFAGAVPNGLLVHPDRDHLIYPLGNTVVIEQIKTGKQSCLSGHTDNVTCVAVSKSGRYLASGQQAHMGFKASVIVWD-YAEKKLKYQLTLHKVKVEALAFSPNDEYLVSLGGQDDGSVVVWDLQAGEAVCGSPAAVPS-AGTTNAVAFANHNDNLFITGGNKTLRV 182          

Query:  640 INLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTT--ASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGV--VAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFA-PKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWE 1263
            I ++T   CF        G+  D     Q  + G   S+  T    S ++R++   ++GE + + I+D +T    + +  P       V+++ + D++YL + S     T   W W   + +    +S   +  +   +SFN  D  Q+          +++ + GNLK FA  K+  Q+F       CH        R ++ T  G L+++E
Sbjct:    3 IAVATPRHCF--------GLKAD---KSQRFIPGSDKSVGMTAMAVSPNRRYVAIAEKGEKATITIYDLHTLRKKKVLSHPEVQSAEFVSLAFSPDSKYLVSQSGRPDWTLLYWTWEKAKVMAFTKSSNQQDSAVYQ-VSFNPQDNTQLCVVGNGIFKLFRYSE-GNLKQFAFQKMEPQNF------LCHAWV--SDERIITGTDTGRLLLFE 194          

Query:  592 ALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHP-NGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL----PKTTRALSATSQGLL----------------VVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILE-NSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLF-SKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVD-GNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVG-EDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGE----LSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEE 3147
            AL+P +  G N   P+  L   ++  + Y+ S  GIIY++  N Q ILQGH+ +ISC   S+D+RW+ T D G  S+VIIWD  +G+PV+T+F  HP  GV+A++ + D ++L TL  E TQ   +WDW      P+C  ++   +G Q Y++    D  Q+ T SE+ VLFY   +  NL+Y A  L  + F K       +  L    P+TT   +A++   L                VVWE +  L+K  N+  SDK  V L  + D  IT LT+    I+TGD  GDI F+D    L+  Y   N  P           +  I F  E   ++ +D  ++       + I+ T  +    +  +   I+ +     +  ++V  HP+ P VA GS  G+LK+W+Y  +     RLF ++  I+ + FD +G+ +AVGF+ G ++IL+ +A++    +    +K  I  I FS  SE+LAT D G   T  +   +   +  W+ + RY +H K I DLLFG + D+  PRL +LG DR+LVEYDL  ++  +L I    RIEQSA+PL   W+P    E F++ A+DQYK+K+ N  TKMCR +  GPTFGSP+K +  LP     +     +K  +LA+   +++GL  +P +GNPY    +I H  GV+SL  S+DG ++ + G  D+   +W+INL++LEA   LGG+ M P+Y  ++GG+ G F  +++++FYY  IR  G   ++++     I +SEVP +MRA+G++P+E+EIE+M NE+KF  + ETGKY   +DL  FIK+YVNHRPAFG  S ++ + F  +  +       L   + L LL  +GE++  N++ E   TLLG  +E
Sbjct:   83 ALSPKWVFGINPDFPVFTLQDKDQLVLLYT-SGFGIIYNHTLNVQHILQGHSTNISCMCVSEDRRWIATADCGSESMVIIWDAYSGIPVQTLFNCHPAGGVIAVAFSSDTKHLVTLGREKTQCVCVWDWIPNSQKPVCFTNIHPEHGFQTYVACRPTDCIQLLTGSESHVLFYSIVE-RNLQYLALDL--KRFMKAENCAAGSAVLLPDPPRTTHRSNASAPWSLFHLRMPQILTVIGRDIVVWEVSDDLVK--NQIVSDKTIVPLC-LQDNPITALTMADGLIITGDTKGDIYFYDETLSLLLLYNKLNLDP-----------IASISFTKECKKEHKQDCILEDEPVVKGNLIICTVNSTVLQLNTQSHSIQTLVHQEQELHHAVACHPSEPFVALGSQQGILKVWDYNKKTVTGRRLFETEGSIQCVSFDLNGIYLAVGFSTGSVQILNANAIQSDSPESLGCTKDSIHIIVFSSDSEYLATADAGKAVTVFHLQKKEGSQRQWICLDRYHSHSKPITDLLFGLHLDSTYPRLLSLGMDRQLVEYDLEKSTVGQLVIKSSDRIEQSAVPLCMAWFPPLTTEQFLLIASDQYKMKLLNSITKMCRKTVQGPTFGSPIKQMMILP-----KHKESKIKSYHLAFITEDRLGLQILPPDGNPYKSTALICHATGVSSLSSSYDGKFVFTTGVSDYSSIMWEINLNVLEAAAALGGNDMIPFYSQLDGGQEGKFYRDMEDFFYYCQIRHYGSSLMRKQPKPTEIPLSEVPSLMRAVGYFPTEQEIEDMQNEIKFSRFAETGKYVTDIDLQEFIKLYVNHRPAFGAPSNELVQAFHVLAKSNSTGQPVLQRQELLELLQARGEQMTMNEVEECFTTLLGLKKE 940          

Query:  571 QDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGK----------FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATVDGNFTTTLY 2007
            +++ P S +   +  G+  Y    NL       I Y  + +G++Y+   N Q    GH + I C      K ++ TG  G +S V +WD  T  P+  +   H  GV A+  + D R L ++  ++  T  +WDW  GE       +LS   G +       D IF V  N       Y  DK+        K   +     IG+           C  ++        S T  G + +W               D   +K V  HD  +  +       VTG   G +  +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       V  K   I ++ + H +  V+ + +HP LPL AT S    L+IW+      +      +   +  CF   G  +AVG  +G   I++   L+D++S  FH  K  I+ I+FS  + ++LA    +    +Y
Sbjct:  669 RERAPASGIKLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNGQQNTQRFYMGHDDDILCLAIHPLKDFVATGQVGRDSSVHVWDTETLKPISVLKGSHQLGVCALDFSADGRRLVSIGLDDNHTIVLWDWRKGE-------TLSAMRGSK-------DKIFVVKINP------YLPDKLITAGVKHMKFWHKAGGGLIGRKGNMGKTETMMC-AVYGWSEEMVFSGTCTGDICIWR--------------DMFLMKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDTFERCLKTYAIKRAVLAPGSK------------GLLLE-----DNPSIRAISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLASHPHLPLCATVSDDKTLRIWDLSPSHCMLAVRKLRKGGRCCCFSPDGKALAVGLNDGSFIIVNADTLEDLVS--FHHRKDAISDIRFSPGAGKYLAVASADSFVDIY 1107          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL--PKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGE---LRILDT-------------HALK-----------------DVLSKPFHFSKVH--------ITHIQFSEKSEFLATVDGNFTTTLYR 2010
            I Y  + +G++Y+   ++Q    GH + I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  ++ + L ++  ++  T  +WDW  G+        L+   G  + I     D++Q +      V   + W   GN     PK   +      G     L L   K     S    G + VW+G ++L++             +   H   I  +        TG   G ++ +D            NF PI+            +  + E     +  +++S  +     +VGT  + IF  V    +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+       G+ +A+G  +G    LR+ D              H LK                 D+      + KV         ITH+ +S  S++L T DG+     YR
Sbjct:   36 IVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILKDVHTHGIACLAFDLEGQCLVSVGLDSKNTICVWDWRRGK-------VLAVAPGHTDRIFDISWDLYQPSKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGKTGDLQTILCLACAKDEITYSGALNGDIYVWKG-INLLRT------------IQGAHGSGIFSMNACEEGFATGGRDGCVRLWDL-----------NFKPIT------------VIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEVVVHDRNKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSL-IDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAHLAVGSNENSVDIYGVVQRYKKVGECMGSNSFITHMDWSTDSKYLQTNDGSGRRLFYR 479          

Query:  571 QDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGK----------FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATVDGNFTTTLY 2007
            +++ P S +   +  G+  Y    NL       I Y  + +G++Y+   N Q    GH + I C      K ++ TG  G +S V +WD  T  P+  +   H  GV A+  + D R L ++  ++  T  +WDW  GE       +LS   G +       D IF V  N       Y  DK+        K   +     IG+           C  ++        S T  G + +W               D   +K V  HD  +  +       VTG   G +  +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       V  K   I ++ + H +  V+ + +HP LPL AT S    L+IW+      +      +   +  CF   G  +AVG  +G   I++   L+D++S  FH  K  I+ I+FS  + ++LA    +    +Y
Sbjct:  669 RERAPASGIKLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNGQQNTQRFYMGHDDDILCLAIHPLKDFVATGQVGRDSSVHVWDTETLKPISVLKGSHQLGVCALDFSADGRRLVSIGLDDNHTIVLWDWRKGE-------TLSAMRGSK-------DKIFVVKINP------YLPDKLITAGVKHMKFWHKAGGGLIGRKGNMGKTETMMC-AVYGWSEEMVFSGTCTGDICIWR--------------DMFLMKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDTFERCLKTYAIKRAVLAPGSK------------GLLLE-----DNPSIRAISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLASHPHLPLCATVSDDKTLRIWDLSPSHCMLAVRKLRKGGRCCCFSPDGKALAVGLNDGSFIIVNADTLEDLVS--FHHRKDAISDIRFSPGAGKYLAVASADSFVDIY 1107          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL--PKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLY 2007
            I Y  + +G++Y+   ++Q    GH + I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  ++ + L ++  ++  T  +WDW  G+        L+   G  + I     D++Q +      V   + W   GN     PK   +      G     L L   K     S    G + VW+G ++L++             +   H   I  +        TG   G ++ +D            NF PI+            +  + E     +  +++S  +     +VGT  + IF  V    +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+       G+ +A+G  +G   +L    + +V+        +H   +++S     LA      +  +Y
Sbjct:   36 IVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILKDVHTHGIACLAFDLEGQCLVSVGLDSKNTICVWDWRRGK-------VLAVAPGHTDRIFDISWDLYQPSKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGKTGDLQTILCLACAKDEITYSGALNGDIYVWKG-INLLRT------------IQGAHGSGIFSMNACEEGFATGGRDGCVRLWDL-----------NFKPIT------------VIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEVVVHDRNKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSL-IDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIH--ELKYSPDGAHLAVGSNENSVDIY 435          

Query:  571 QDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGK----------FCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKS-EFLATVDGNFTTTLY 2007
            +++ P S +   +  G+  Y    NL       I Y  + +G++Y+   N Q    GH + I C      K ++ TG  G +S V +WD  T  P+  +   H  GV A+  + D R L ++  ++  T  +WDW  GE       +LS   G +       D IF V  N       Y  DK+        K   +     IG+           C  ++        S T  G + +W               D   +K V  HD  +  +       VTG   G +  +D  +   +  +  +     P S               +LE     ++ +I++        +VGT       V  K   I ++ + H +  V+ + +HP LPL AT S    L+IW+      +      +   +  CF   G  +AVG  +G   I++   L+D++S  FH  K  I+ I+FS  + ++LA    +    +Y
Sbjct:  669 RERAPASGIKLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNGQQNTQRFYMGHDDDILCLAIHPLKDFVATGQVGRDSSVHVWDTETLKPISVLKGSHQLGVCALDFSADGRRLVSIGLDDNHTIVLWDWRKGE-------TLSAMRGSK-------DKIFVVKINP------YLPDKLITAGVKHMKFWHKAGGGLIGRKGNMGKTETMMC-AVYGWSEEMVFSGTCTGDICIWR--------------DMFLMKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDTFERCLKTYAIKRAVLAPGSK------------GLLLE-----DNPSIRAISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLASHPHLPLCATVSDDKTLRIWDLSPSHCMLAVRKLRKGGRCCCFSPDGKALAVGLNDGSFIIVNADTLEDLVS--FHHRKDAISDIRFSPGAGKYLAVASADSFVDIY 1107          

Query:  670 IFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQ-WDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFL--PKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTA-TAIFATVTVKGSKIKVIFRDH-DQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLY 2007
            I Y  + +G++Y+   ++Q    GH + I       ++  + TG  G+   + +WD  T   V  + + H +G+  ++  ++ + L ++  ++  T  +WDW  G+        L+   G  + I     D++Q +      V   + W   GN     PK   +      G     L L   K     S    G + VW+G ++L++             +   H   I  +        TG   G ++ +D            NF PI+            +  + E     +  +++S  +     +VGT  + IF  V    +K  +I + H +  ++++  HPT PL  TGS    ++IW+     ++  R   + PI+       G+ +A+G  +G   +L    + +V+        +H   +++S     LA      +  +Y
Sbjct:   36 IVYFVAGVGVVYNTREHKQKFYLGHNDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSILKDVHTHGIACLAFDLEGQCLVSVGLDSKNTICVWDWRRGK-------VLAVAPGHTDRIFDISWDLYQPSKLVSCGVKHIKFWSLCGNA--LTPK---RGVFGKTGDLQTILCLACAKDEITYSGALNGDIYVWKG-INLLRT------------IQGAHGSGIFSMNACEEGFATGGRDGCVRLWDL-----------NFKPIT------------VIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEVVVHDRNKPFLIMQGHCEGELWALAVHPTKPLAMTGSDDRSVRIWSL-IDHALIARCNMEEPIRCAAVSTDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIH--ELKYSPDGAHLAVGSNENSVDIY 435          

Query:  550 EQLPQI--------SQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNY---MLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLC-FDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLY 2007
            E LPQ+         + K P   L   +   +  +    NL       + Y  + +G++Y+   + Q    GH + I   T    K ++ +   G +  + +WD  T   +  +   H  GV A+  T D + L ++  + + +  IWDW  GE   L  A       +     F  D +  V       + F  W   G L +      +    + +   C+           S  + G + +W               D   +K +  HD  +  +       VTG   G ++ +D  +   +  +  +     P S             K +LE     ++ +I++        ++GT       +   G    ++    +  V+ + AHP LP+ AT S    L+IW   +   +      K+     C F   G  +AVG  +G   +++   L+D+++  FH  +  I+ I+FS+  ++LA    +    +Y
Sbjct:  369 EDLPQLRKKLIGSLKRQKAPEEGLRLQFVHRYRGFDCRNNLYYSQTGEVVYHVAAVGVVYNRLQHSQRFYLGHDDDILSLTVHPLKDYVASAQVGRDPGIHVWDTQTLNCLSLLRGQHNRGVCALEFT-DGKSLISVGIDESHSIVIWDWKKGE--RLSKAGHKDKIFVVKSNPFRMDKLVTVGIK---HIKF--WQHSGGLTFRRGIFGNLGRQETMMSACYG---RSEDLLFSGATNGDVYIWR--------------DTTLIKTIKAHDGPVFAMCSLDKGFVTGGKDGVVELWDDMFERCLKTYAIKRATLSPSS-------------KLLLE-----DNPSIRAITLGHGHILLGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPVCATVSDDKTLRIWELSSNHRMVA--VRKLKRGRCCAFSPDGKALAVGLNDGSFLVVNADTLEDMVT--FHHRRELISDIRFSQVGKYLAVASNDSFVDIY 819          

Query:   61 MDQDEDIKNLDXXXXXXXXXXKEMDDINTVEINNKNESVEXXXXXXXXXXXXXXXXXKNDVADIRFDEDYNITNDIDVNENIDSFDSLDEENKVNLEKFTNLENDAINTNEITKXXXXXXXXXXXXXXXXXXXXXXKDTKIYISHSENHSPTPQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLE-------KIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQVAYPTKSNNTLANSTQT 3336
            MDQDEDIKNLDSYEENESN+SKEMDDINTVEINNKNESVENADNDINDDNDQIESIIKND+ADI FDEDYNITNDIDVNENIDSFDSLDEENKVNLEKFTNLENDAINTNEITKEFEECQNENNLENINEDINNSNKDTKIYISHSENHSPTPQRILSESKNF+QLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPISSISSSTSTSLE       KIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRES+KTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPI TNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQVAYPTKSNNTLANSTQT
Sbjct:    1 MDQDEDIKNLDSYEENESNSSKEMDDINTVEINNKNESVENADNDINDDNDQIESIIKNDIADISFDEDYNITNDIDVNENIDSFDSLDEENKVNLEKFTNLENDAINTNEITKEFEECQNENNLENINEDINNSNKDTKIYISHSENHSPTPQRILSESKNFDQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPISSISSSTSTSLENKNIPDWKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESVKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIVTNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQVAYPTKSNNTLANSTQT 1099          

Query:   61 MDQDEDIKNLDXXXXXXXXXXKEMDDINTVEINNKNESVEXXXXXXXXXXXXXXXXXKNDVADIRFDEDYNITNDIDVNENIDSFDSLDEENKVNLEKFTNLENDAINTNEITKXXXXXXXXXXXXXXXXXXXXXXKDTKIYISHSENHSPTPQRILSESKNFEQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIK----------------VPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIATNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQVAYPTKSNNTLANSTQT 3336
            MDQDEDIKNLDSYEENESN+SKEMDDINTVEINNKNESVENADNDINDDNDQIESIIKND+ADI FDEDYNITNDIDVNENIDSFDSLDEENKVNLEKFTNLENDAINTNEITKEFEECQNENNLENINEDINNSNKDTKIYISHSENHSPTPQRILSESKNF+QLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIK                VPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPISSISSSTSTSLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRES+KTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPI TNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQVAYPTKSNNTLANSTQT
Sbjct:    1 MDQDEDIKNLDSYEENESNSSKEMDDINTVEINNKNESVENADNDINDDNDQIESIIKNDIADISFDEDYNITNDIDVNENIDSFDSLDEENKVNLEKFTNLENDAINTNEITKEFEECQNENNLENINEDINNSNKDTKIYISHSENHSPTPQRILSESKNFDQLPQISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKEYVHDDIANINIIRFKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPISSISSSTSTSLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYAHPTLPLVATGSYSGLLKIWNYETRESVKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYRPGRNNVEEPWVYVARYRAHYKKILDLLFGRYFDTETPRLFTLGEDRRLVEYDLYNASEDKLPILQETRIEQSAIPLTFCWYPEENGEGFIVTANDQYKLKMYNHQTKMCRYSFLGPTFGSPVKILKTLPIVTNNRSINDNVKRRYLAYANRNKIGLIRIPLNGNPYNYMTMIAHPRGVTSLCCSFDGNYLISVGEDFIVTVWKINLDILEAQYQLGGDGMTPYYELIEGGEFGNFIHELKEYFYYSMIRTQGIDSLQRRHVDIVIDISEVPYIMRAIGFYPSEEEIENMLNELKFKDYFETGKYSDKVDLNTFIKVYVNHRPAFGISSEKIEETFRTIIHNEGELSIDKFLNLLMNKGEKINENDLAEYLATLLGFNEEGGSLEMEDFNPDKVMKSVNEALPKVVTTKTFIENIICMKIVDRESQVAYPTKSNNTLANSTQT 1108          

Query:  565 ISQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFN-KPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKG-SKIKVIFRDHDQS-VYSVYAHPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLA 1974
            +S    P S LT  +  G+  +    NL   N   I Y  + +GI+YD    +Q     H + I     + D   + TG  G++  + IW+ N+      + + H +G+ +++ + +  YL ++  +   T  +WDW  G+ +    A     +  +  +S   D   +  T     + F  W   GN       +  +    + I   C  + +       S T  G + +W  N +L +V            +  VH  A+  +    S  VTG     +   D  +  M                       +I   L N  YP +  ++S  +  ++ +VGT  +    + V   +K K +   H    ++++  HP   + ATGS    L+IW    RE + T    K  I+S  F+H G  IA+G  +G   ++ T  + +V +       +H   ++FS    +LA
Sbjct:    1 MSNKLAPNSQLTLDWVYGYRGHQCHNNLFYTNSEKIVYFVAGIGIVYDIKQRKQFYYFEHNDDIISLALASDGELVATGQVGKSPFICIWNSNSLETKSILKDQHTHGISSVAFSKNGMYLLSVGLDPNATLNVWDWKKGKVLSSTRAHSDRVFDARFMVS---DGPIKFVTCGIKHIKF--WSLCGNTLSSKKGIYGKKGEIQTILTVC--MSISDNAVCYSGTLNGDVYIWREN-NLERV------------IATVHSGALYSIESCASGYVTGGKDSCVVLHDPEFQPM----------------------TRIDLKLTNIGYP-NLIVRSVHWLSNNVLVGTQGSDIIEIPVSTPNKPKSLMMGHAAGELWALGVHPKKSIFATGSDDCSLRIWQMNEREPLTTLRIDK-KIRSCGFNHDGSLIAIGIMDGSFSVIRTRDMIEVHNAQDRKEVLH--ELKFSPDGHWLA 427          

Query:  571 QDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDFNKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDVGGDIKFFDYNYMLMFWYQDWNFGPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQS-VYSVYAHPTLPLVATGSYSGLLKIWNYE-TRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFS 1953
            + K P   L   +  G+  Y    N+       I +  + +GI+ +     Q     H + I C      K  + TG+ G    + +WD  T   V  +   H  GV A+  + D + LA++  ++     +WDW  GE +    AS   +      I ++  +  Q+       + F  W ++G   +   + T  +  K   + C      K     + +  GL+ +W+ N+                  V +H+     +       VTG   G IK  D  +  +  ++ +   P          +L+  + +  +S  P   TI+S        +  T++     ++  G+ I ++ + H +  ++ +  HP+  + AT S    L IW  E +   +      K P +       G  +AVGF +G   +L   +L ++ S   H  K  I+ I+FS
Sbjct:  665 RKKAPSQGLQLEWVHGYRGYDCRNNIFYLQSGEIVFHVAAVGIVMNIASKTQRFYASHNDDILCLGLHPLKDLIATGEVGREPTIHVWDTQTMKSVSILKGEHERGVCAVDFSSDGKKLASVGLDDNHLLVVWDWRKGEKL----ASTRAHKDKIFMIKWDPHNNNQLVAVGMKFIRF--WTQVGG-GFTTKRGTFGNVAKLDTQLCAAYNPNKPGVCYTGSPSGLVYIWKDNI--------------LQSAVMMHEGGCYAIDALDKGFVTGGKDGTIKLCDETFTKV--HKSYKLSP---------ENLQPQQML--SSACP---TIRSVVLGKGKILASTSSGEIMELSTDGT-INILVQGHGEGELWGLAVHPSKNICATVSDDCYLMIWEVEPSNHKLIKLKKLKGPARCCDISCDGSAVAVGFKDGSFLVLSLTSLGEIASS--HHRKEEISDIKFS 1087          

Query:  502 NHSPTPQRILSESKN--FEQLPQISQDKNPVSALTPVYSL-GFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRW---LGTGDQGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSASLSTNYGLQNYISFNCDDIFQVTTNSETQVLFYQWDKIGNLKYFAPKLTDQDF-NKPIGKFCHTLFLPKTTRALSATSQGLLVVWEGNVSLIKVPNESTSDKKAVKLVPVHDKAITVLTLTGSFIVTGDV-----GGDIKFFDYNYML---MFWYQDWNF-GPXXXXXXXXXXXLEKIKFILENSDYPEDTTIQSNKFAIHDFIVGTATAIFATVTVKGSKIKVIFRDHDQSVYSVYA-HPTLPLVATGSYSGLLKIWNYETRESIKTRLFSKIPIKSLCFDHHGVQIAVGFANGELRILDTHALKDVLSKPFHFSKVHITHIQFSEKSEFLATVDGNFTTTLYR 2010
            N   TP+R++S+  N   E++ Q+         L  V+   GF+    +  L  +    ++++ + +GI+++    +Q     H + I C T ++  ++   + TG  G    + +W+      + T+   H NG+ ++  +     L ++  +N  T A+W W TG    L  A+  T          + D IF         V F  W   G+           DF N+P      ++         +    G + VW+  V L ++  ++ S        PV    +   TL    IV+G        G IK +D   +     +  +D N  G   +       S+E I+            +I   K  I   ++GT       +  K   +K + + H + V    A HP LP  ++ S  G ++IW+ ET+  I++   +  P   + +  +G  + +G  +G   +L   + + ++ K     +  IT I+FS  S  +A    +    +Y+
Sbjct: 1375 NGKTTPRRLISDPPNPVIEKVTQLE--------LKHVHGYRGFDCRNNLHYLDAEGSSIVYHAAA-VGIVHNLQSGQQSFFLEHNDDILCLTVNRHPKYRNVVATGQIGAIPSIHVWNSLDCTKLSTLKGVHINGICSLDFSSTGTLLLSVGIDNDHTIAVWKWETG--TLLAKANGHTQRIFLAEFRPDSDSIF--VNVGVKHVKF--WTLAGSELIAKRGRIPSDFVNQPRMTTMLSVAFCTNDTTYTGAMNGSVWVWKSGV-LTRIVEKAHSG-------PVF---VLFTTLVDGLIVSGGKEKGKDTGSIKLWDQEMIRNKPFYLAEDINVRGSSETAKPLEDKSMEVIR------------SISRVKGKI---LLGTQDNDILEILEKQGTVKYLMQAHGEGVLCGLAVHPFLPQYSSASEDGTVRIWDLETKMLIQS--LTTGPATCVDYSPNGNYLVIGLKSGAFVVLSAQSYRLLIRKKDRGKQ--ITDIKFSPNSSLIAVGSNDNVVDIYK 1849          

Query:  568 SQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGD---QGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSA 1008
             ++ N ++ L  +  +GFN  +        +R  I Y      +I D     Q  LQGHTN++ C T S   +++ +G     G  + +++WD  T   V T F  H   V +++ + + +YLA+L  ++     IW  T  E  P+C +
Sbjct:    3 GEEVNEINKLELINVIGFNGTILDGLHVHPDRQHIIYGLGCTVVIEDLNTKNQCFLQGHTNNVVCITVSNSGKYIASGQITHMGYKADIMLWDYVTKQCVST-FSLHKVKVQSLAFSPNEKYLASLGGQDDGCVVIWSLTKME--PICGS 149          

Query:  568 SQDKNPVSALTPVYSLGFNRYVPIINLSTDNRCFIFYSCSHLGIIYDYYHNEQLILQGHTNSISCTTASKDKRWLGTGD---QGENSVVIIWDCNTGLPVRTMFEPHPNGVVAISLTMDARYLATLSAENTQTFAIWDWTTGEDVPLCSA 1008
             ++ N ++ L  +  +GFN  +        +R  I Y      +I D     Q  LQGHTN++ C T S   +++ +G     G  + +++WD  T   V T F  H   V +++ + + +YLA+L  ++     IW  T  E  P+C +
Sbjct:    3 GEEVNEINKLELINVIGFNGTILDGLHVHPDRQHIIYGLGCTVVIEDLNTKNQCFLQGHTNNVVCITVSNSGKYIASGQITHMGYKADIMLWDYVTKQCVST-FSLHKVKVQSLAFSPNEKYLASLGGQDDGCVVIWSLTKME--PICGS 149