Neuropeptide Y prohormone 1
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30026988 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Neuropeptide Y prohormone 1 vs. UniProt/SwissProt
Match: sp|Q27441|NPY_APLCA (Pro-neuropeptide Y OS=Aplysia californica OX=6500 GN=NPY PE=1 SV=1) HSP 1 Score: 56.225 bits (134), Expect = 2.535e-10 Identity = 24/55 (43.64%), Postives = 36/55 (65.45%), Query Frame = 2 Query: 104 CLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFD 268 C+ +++V + + PP +PE F + LR Y+ LNEY++I+GRPRFGKR D Sbjct: 13 CMAVLSVRADNSEM-LAPPPRPEEFTSAQQLRQYLAALNEYYSIMGRPRFGKRGD 66
BLAST of Neuropeptide Y prohormone 1 vs. UniProt/SwissProt
Match: sp|P0CJ22|NPY1_CONBE (Neuropeptide Y1-like conopeptide OS=Conus betulinus OX=89764 PE=1 SV=1) HSP 1 Score: 46.595 bits (109), Expect = 3.939e-7 Identity = 21/34 (61.76%), Postives = 26/34 (76.47%), Query Frame = 2 Query: 152 EPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRF 253 +PPA+P F E L NY+++LN YFAIVGRPRF Sbjct: 4 DPPARPAVFHSREELMNYVRELNRYFAIVGRPRF 37
BLAST of Neuropeptide Y prohormone 1 vs. UniProt/SwissProt
Match: sp|P41321|NPF_CORAP (Neuropeptide F OS=Cornu aspersum OX=6535 PE=1 SV=1) HSP 1 Score: 45.4394 bits (106), Expect = 1.185e-6 Identity = 19/38 (50.00%), Postives = 26/38 (68.42%), Query Frame = 2 Query: 140 SLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRF 253 + + PP +P F P LR Y+K+LNEY+AI+GR RF Sbjct: 2 TQMLSPPERPREFRHPNELRQYLKELNEYYAIMGRTRF 39
BLAST of Neuropeptide Y prohormone 1 vs. UniProt/SwissProt
Match: sp|P0CJ23|NPY2_CONBE (Neuropeptide Y2-like conopeptide OS=Conus betulinus OX=89764 PE=1 SV=1) HSP 1 Score: 44.669 bits (104), Expect = 1.834e-6 Identity = 20/34 (58.82%), Postives = 26/34 (76.47%), Query Frame = 2 Query: 152 EPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRF 253 +PPA+P F E L NY+++LN YFAIVGRPR+ Sbjct: 4 DPPARPAVFHSREELMNYVRELNLYFAIVGRPRY 37
BLAST of Neuropeptide Y prohormone 1 vs. TrEMBL
Match: E3T7T7 (Neuropeptide Y prohormone 1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 137.887 bits (346), Expect = 2.111e-40 Identity = 67/67 (100.00%), Postives = 67/67 (100.00%), Query Frame = 2 Query: 80 MTFIYGFLCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDRGFS 280 MTFIYGFLCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDRGFS Sbjct: 1 MTFIYGFLCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDRGFS 67
BLAST of Neuropeptide Y prohormone 1 vs. TrEMBL
Match: A0A3P7LY16 (Uncharacterized protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS6882 PE=3 SV=1) HSP 1 Score: 60.4622 bits (145), Expect = 1.705e-9 Identity = 24/36 (66.67%), Postives = 31/36 (86.11%), Query Frame = 2 Query: 149 IEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFG 256 ++PP KP F +PE LRNYI+K+NEYFA++GRPRFG Sbjct: 58 MQPPVKPPAFSNPEALRNYIRKVNEYFALIGRPRFG 93
BLAST of Neuropeptide Y prohormone 1 vs. TrEMBL
Match: Q9U0S9 (Neuropeptide Y OS=Lymnaea stagnalis OX=6523 GN=NPY PE=2 SV=1) HSP 1 Score: 60.077 bits (144), Expect = 2.006e-9 Identity = 28/51 (54.90%), Postives = 37/51 (72.55%), Query Frame = 2 Query: 110 TLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKR 262 ++ V+C++ L PP +PE F +P LR Y+K LNEY+AIVGRPRFGKR Sbjct: 15 AVMEVLCTEAML--TPPQRPEEFKNPNELRKYLKALNEYYAIVGRPRFGKR 63
BLAST of Neuropeptide Y prohormone 1 vs. TrEMBL
Match: A0A210PXD3 (Neuropeptide F OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT04777 PE=2 SV=1) HSP 1 Score: 60.077 bits (144), Expect = 2.428e-9 Identity = 25/57 (43.86%), Postives = 42/57 (73.68%), Query Frame = 2 Query: 101 LCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDR 271 +C LV+ + Q+++ +EPP +P F P+ LR+Y++ LNEY++IVGRPRFG+ ++ Sbjct: 12 VCALLVSQVTCQEAM-LEPPDRPHSFRTPDQLRSYLRALNEYYSIVGRPRFGRSVNK 67
BLAST of Neuropeptide Y prohormone 1 vs. TrEMBL
Match: G4LVY8 (Neuropeptide Y,putative OS=Schistosoma mansoni OX=6183 GN=Smp_159950 PE=3 SV=1) HSP 1 Score: 60.4622 bits (145), Expect = 2.719e-9 Identity = 26/46 (56.52%), Postives = 34/46 (73.91%), Query Frame = 2 Query: 125 ICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKR 262 I +++ I PP +P F+ PE LR Y+ KLNEYFAI+GRPRFG+R Sbjct: 74 IIKTRAVEIVPPERPFIFETPEALRTYLHKLNEYFAIIGRPRFGRR 119
BLAST of Neuropeptide Y prohormone 1 vs. Planmine SMEST
Match: SMESG000069090.1 (SMESG000069090.1) HSP 1 Score: 137.887 bits (346), Expect = 5.871e-44 Identity = 67/67 (100.00%), Postives = 67/67 (100.00%), Query Frame = 2 Query: 80 MTFIYGFLCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDRGFS 280 MTFIYGFLCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDRGFS Sbjct: 1 MTFIYGFLCLTLVNVICSQKSLFIEPPAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKRFDRGFS 67
BLAST of Neuropeptide Y prohormone 1 vs. Planmine SMEST
Match: SMESG000066803.1 (SMESG000066803.1) HSP 1 Score: 44.669 bits (104), Expect = 3.663e-7 Identity = 22/54 (40.74%), Postives = 30/54 (55.56%), Query Frame = 2 Query: 104 CLTLVNVICSQKSLFIEP-PAKPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKR 262 C LV ++C + + K FD + RNY++KLN + I GRPRFGKR Sbjct: 6 CYFLVFILCFMSFIHLNTCNQKRPMFDSADAFRNYLRKLNNEYMIAGRPRFGKR 59
BLAST of Neuropeptide Y prohormone 1 vs. Planmine SMEST
Match: SMESG000048959.1 (SMESG000048959.1) HSP 1 Score: 44.2838 bits (103), Expect = 4.112e-7 Identity = 18/33 (54.55%), Postives = 23/33 (69.70%), Query Frame = 2 Query: 164 KPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKR 262 + F PE LR Y+ ++NEY AIV RPR+GKR Sbjct: 21 RKSIFSSPEALRRYLLQMNEYLAIVARPRYGKR 53
BLAST of Neuropeptide Y prohormone 1 vs. Planmine SMEST
Match: SMESG000048959.1 (SMESG000048959.1) HSP 1 Score: 44.669 bits (104), Expect = 4.452e-7 Identity = 18/33 (54.55%), Postives = 23/33 (69.70%), Query Frame = 2 Query: 164 KPEFFDDPELLRNYIKKLNEYFAIVGRPRFGKR 262 + F PE LR Y+ ++NEY AIV RPR+GKR Sbjct: 35 RKSIFSSPEALRRYLLQMNEYLAIVARPRYGKR 67 The following BLAST results are available for this feature:
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 4
BLAST of Neuropeptide Y prohormone 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Neuropeptide Y prohormone 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30026988 ID=SMED30026988|Name=Neuropeptide Y prohormone 1|organism=Schmidtea mediterranea sexual|type=transcript|length=351bpback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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