Melanocortin 4 receptor
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30026936 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Melanocortin 4 receptor vs. Ensembl Human
Match: MC4R (melanocortin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6932]) HSP 1 Score: 66.6254 bits (161), Expect = 2.410e-11 Identity = 69/299 (23.08%), Postives = 133/299 (44.48%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS-------LIAAEMKKTPGPCFHL----LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
+G ++L +L ++ IA + P F+CSL +AD +V VS + T F + ++ S+ ++ SI SL +A+D Y +F+ L+Y +M + + I+S +W + G I F +++++ +++ C I + +M Y ++F + L + IRQ ++G T I++ VF+ C++P+F L IF IS N H + +L+++ NS I+P++YA R +E+R +++ +
Sbjct: 54 LGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSG--------ILFIIYSDSSAVI---------------------ICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFF-------LHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEI 316
BLAST of Melanocortin 4 receptor vs. Ensembl Human
Match: MC5R (melanocortin 5 receptor [Source:HGNC Symbol;Acc:HGNC:6933]) HSP 1 Score: 64.6994 bits (156), Expect = 8.038e-11 Identity = 73/323 (22.60%), Postives = 135/323 (41.80%), Query Frame = 2
Query: 230 NQNNISYENSDRNVGILIFF-IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS----------------LIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
N N S D + + +F +G ++L +L + I + P F+CSL +AD +V +S +IA + F S+ + S+ SL +A+D YV +F+ LRY +M R I++ +W FC G FI + + Y C I + +++ Y ++F + L + RQ+ ++G T ++L VF C++P+F + L+ + + Q SR F++ L++ NS ++P++YAFR +E+R +++ +
Sbjct: 25 NVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFD----SMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIW----------------AFCT------------GCGIVFILYSESTYVI-LCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFF-----LHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEI 309
BLAST of Melanocortin 4 receptor vs. Ensembl Human
Match: MC5R (melanocortin 5 receptor [Source:HGNC Symbol;Acc:HGNC:6933]) HSP 1 Score: 64.6994 bits (156), Expect = 8.038e-11 Identity = 73/323 (22.60%), Postives = 135/323 (41.80%), Query Frame = 2
Query: 230 NQNNISYENSDRNVGILIFF-IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS----------------LIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
N N S D + + +F +G ++L +L + I + P F+CSL +AD +V +S +IA + F S+ + S+ SL +A+D YV +F+ LRY +M R I++ +W FC G FI + + Y C I + +++ Y ++F + L + RQ+ ++G T ++L VF C++P+F + L+ + + Q SR F++ L++ NS ++P++YAFR +E+R +++ +
Sbjct: 25 NVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFD----SMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIW----------------AFCT------------GCGIVFILYSESTYVI-LCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFF-----LHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEI 309
BLAST of Melanocortin 4 receptor vs. Ensembl Human
Match: MC3R (melanocortin 3 receptor [Source:HGNC Symbol;Acc:HGNC:6931]) HSP 1 Score: 57.7658 bits (138), Expect = 1.466e-8 Identity = 74/302 (24.50%), Postives = 127/302 (42.05%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHN-------------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFR-KILEFNRDFIKLQASQVIRQKRG-VRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
+G ++L +L +L + + P FLCSL +AD +V VS A E L + + H SI +L +A+D YV +F+ LRY +M R L ++ +W+ + G + F V++ + ++ C I + L+M Y ++F L R A V Q+ ++G T I+L VF+ C++P FF + + ++ N I T F+ L++ NS I+P++YAFR E+R ++R +
Sbjct: 48 LGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVS-NALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCG--------VVFIVYSESKMVIV---------------------CLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAP-FFLHLVLIITCPTNPYCIC----YTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREIL 314
BLAST of Melanocortin 4 receptor vs. Ensembl Human
Match: MC2R (melanocortin 2 receptor [Source:HGNC Symbol;Acc:HGNC:6930]) HSP 1 Score: 56.9954 bits (136), Expect = 2.375e-8 Identity = 75/324 (23.15%), Postives = 139/324 (42.90%), Query Frame = 2
Query: 230 NQNNISYENSDRNVGIL---IFFIGSLALTSQLLTVLVIAFSWKKL-LPNIKFLCSLVMADTMVCVSLIAAEM--------KKTPGPCFHL----LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISL--STIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
N NN + NSD +L IFF S+ + L VL+ F K L P F+CSL ++D + + I + P F ++ SL + GSI SL+ +A D Y+ +F LRY ++ R + +++++W G I ++++++ V + S F +++ +L Y ++F R L + ++G T I+L VF+ C++P+ + ++ S + +S F V+G L++ N+ I+P +YAFR E+R +++++
Sbjct: 10 NINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTG--------ITMVIFSHHVPTVIT---------------FTSLFPLMLVFILCL------YVHMFLLARSHTRKISTL-------PRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMS-------LFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKM 290
BLAST of Melanocortin 4 receptor vs. Ensembl Celegans
Match: npr-16 (NeuroPeptide Receptor family [Source:UniProtKB/TrEMBL;Acc:A0A3B1DQQ4]) HSP 1 Score: 62.003 bits (149), Expect = 3.323e-10 Identity = 60/277 (21.66%), Postives = 120/277 (43.32%), Query Frame = 2
Query: 374 FLCSLVMAD-----TMVCVSLIAAEMKKTP-GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMA--------QGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVF-LSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
++ L +AD ++ V+ + K P GP L + T S++ + LA D Y+A+ RT +F+ + WI + F S+ V+ + I + P C W + + C+++I +L L++ +CY ++F K+ E + +L ++ R + + +T ++ + +F L C+SP++ F ++ S IF + + R I ++ +N +NP+LYA+R R +++ L
Sbjct: 46 YMIGLCLADFIYLADLILVAATSLNGKSWPFGPTICHLFHGTEATGKYASVLFVVLLAADRYIAMCKSDLCGRYRTYRTAIFLSGLAWIAA--------FICSLPLYVYADEIKVRMRPKNGTDSIENNHTLCIAHWPSPPHAQWYISVCSVMIFILPGLVIFYCYYHVFCKLREAAKGSRRLHRNK--RSRSSYQRVTRSVQRVVLFHLLCWSPFWLFNLF---SAIFRVRITTQLMR--IIVNIIHLFPYVNCALNPVLYAYRAENFRTAFKSLL 307
BLAST of Melanocortin 4 receptor vs. Ensembl Celegans
Match: npr-16 (NeuroPeptide Receptor family [Source:UniProtKB/TrEMBL;Acc:A0A3B1DQQ4]) HSP 1 Score: 62.003 bits (149), Expect = 3.325e-10 Identity = 60/277 (21.66%), Postives = 120/277 (43.32%), Query Frame = 2
Query: 374 FLCSLVMAD-----TMVCVSLIAAEMKKTP-GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMA--------QGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVF-LSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
++ L +AD ++ V+ + K P GP L + T S++ + LA D Y+A+ RT +F+ + WI + F S+ V+ + I + P C W + + C+++I +L L++ +CY ++F K+ E + +L ++ R + + +T ++ + +F L C+SP++ F ++ S IF + + R I ++ +N +NP+LYA+R R +++ L
Sbjct: 46 YMIGLCLADFIYLADLILVAATSLNGKSWPFGPTICHLFHGTEATGKYASVLFVVLLAADRYIAMCKSDLCGRYRTYRTAIFLSGLAWIAA--------FICSLPLYVYADEIKVRMRPKNGTDSIENNHTLCIAHWPSPPHAQWYISVCSVMIFILPGLVIFYCYYHVFCKLREAAKGSRRLHRNK--RSRSSYQRVTRSVQRVVLFHLLCWSPFWLFNLF---SAIFRVRITTQLMR--IIVNIIHLFPYVNCALNPVLYAYRAENFRTAFKSLL 307
BLAST of Melanocortin 4 receptor vs. Ensembl Celegans
Match: npr-16 (NeuroPeptide Receptor family [Source:UniProtKB/TrEMBL;Acc:A0A3B1DQQ4]) HSP 1 Score: 62.003 bits (149), Expect = 3.940e-10 Identity = 60/277 (21.66%), Postives = 120/277 (43.32%), Query Frame = 2
Query: 374 FLCSLVMAD-----TMVCVSLIAAEMKKTP-GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMA--------QGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVF-LSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
++ L +AD ++ V+ + K P GP L + T S++ + LA D Y+A+ RT +F+ + WI + F S+ V+ + I + P C W + + C+++I +L L++ +CY ++F K+ E + +L ++ R + + +T ++ + +F L C+SP++ F ++ S IF + + R I ++ +N +NP+LYA+R R +++ L
Sbjct: 56 YMIGLCLADFIYLADLILVAATSLNGKSWPFGPTICHLFHGTEATGKYASVLFVVLLAADRYIAMCKSDLCGRYRTYRTAIFLSGLAWIAA--------FICSLPLYVYADEIKVRMRPKNGTDSIENNHTLCIAHWPSPPHAQWYISVCSVMIFILPGLVIFYCYYHVFCKLREAAKGSRRLHRNK--RSRSSYQRVTRSVQRVVLFHLLCWSPFWLFNLF---SAIFRVRITTQLMR--IIVNIIHLFPYVNCALNPVLYAYRAENFRTAFKSLL 317
BLAST of Melanocortin 4 receptor vs. Ensembl Celegans
Match: npr-16 (NeuroPeptide Receptor family [Source:UniProtKB/TrEMBL;Acc:A0A3B1DQQ4]) HSP 1 Score: 62.003 bits (149), Expect = 4.183e-10 Identity = 60/277 (21.66%), Postives = 120/277 (43.32%), Query Frame = 2
Query: 374 FLCSLVMAD-----TMVCVSLIAAEMKKTP-GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMA--------QGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVF-LSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
++ L +AD ++ V+ + K P GP L + T S++ + LA D Y+A+ RT +F+ + WI + F S+ V+ + I + P C W + + C+++I +L L++ +CY ++F K+ E + +L ++ R + + +T ++ + +F L C+SP++ F ++ S IF + + R I ++ +N +NP+LYA+R R +++ L
Sbjct: 56 YMIGLCLADFIYLADLILVAATSLNGKSWPFGPTICHLFHGTEATGKYASVLFVVLLAADRYIAMCKSDLCGRYRTYRTAIFLSGLAWIAA--------FICSLPLYVYADEIKVRMRPKNGTDSIENNHTLCIAHWPSPPHAQWYISVCSVMIFILPGLVIFYCYYHVFCKLREAAKGSRRLHRNK--RSRSSYQRVTRSVQRVVLFHLLCWSPFWLFNLF---SAIFRVRITTQLMR--IIVNIIHLFPYVNCALNPVLYAYRAENFRTAFKSLL 317
BLAST of Melanocortin 4 receptor vs. Ensembl Celegans
Match: tkr-3 (TachyKinin Receptor family [Source:UniProtKB/TrEMBL;Acc:Q58AU0]) HSP 1 Score: 49.2914 bits (116), Expect = 3.733e-6 Identity = 59/221 (26.70%), Postives = 107/221 (48.42%), Query Frame = 2
Query: 503 SIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILG-SSGLFYPSINFCVWNNNISIVTNPMAQGYCF-IQWDCNIYRSGFCTIVIL--VLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSP-YFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
S+ +L A+ + +FF C M+ R+ V ++WI++ ++ GLF+ + F +NN SIV C + D +++ +VI+ + +I+ Y I KI ++ ++L +++ QK L TLII+ ++CFS +F E Y+ L+ + +I+ + + F S +L + NS +NPI+Y + YRRLF
Sbjct: 133 SVFTLVTSAVHEFRTMFF--SKCSQMSPRSAKRCVLLIWIMAVLVSLPHGLFHNTYEFPD-DNNTSIVQ-------CLPVYPDAGWWKTYNVYLVIIQYFVPMIILDTAYTMIAVKIWSLSQSRVELDETKMATQK-----LMRTLIIV---VACFSLCWFPLETYLLLNEL--KPEINGWKYINLVFFFSHWLAMSNSCLNPIIYGLYNTKYNEEYRRLF 333
BLAST of Melanocortin 4 receptor vs. Ensembl Fly
Match: TkR86C (gene:FBgn0004841 transcript:FBtr0112789) HSP 1 Score: 62.7734 bits (151), Expect = 3.825e-10 Identity = 52/223 (23.32%), Postives = 108/223 (48.43%), Query Frame = 2
Query: 503 SIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFC----TIVILVLS----ALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
S+ +L ++ D Y+A+ PL+ +RR + I+ ++W +SC+L + L Y SI + N S + CF+ W Y + ++ILVL+ ++M+ CY ++ ++L +R + Q+ K + + + I+S+F C+ PY F IY ++ +Q+++ + +L + N+ +NP++Y + + R ++R+
Sbjct: 170 SVFTLVAISFDRYIAIVHPLKR--RTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKS-------RTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICY-SLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIY-----AYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRI 377
BLAST of Melanocortin 4 receptor vs. Ensembl Fly
Match: TkR86C (gene:FBgn0004841 transcript:FBtr0082315) HSP 1 Score: 62.3882 bits (150), Expect = 4.906e-10 Identity = 65/291 (22.34%), Postives = 131/291 (45.02%), Query Frame = 2
Query: 503 SIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFC----TIVILVLS----ALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF-EFQXXXXXXXXXXXXXXVTKRNFSLRLKRYKIKEREDSCSRRHSDPENIPLQESCPVSKMTDVQSP 1348
S+ +L ++ D Y+A+ PL+ +RR + I+ ++W +SC+L + L Y SI + N S + CF+ W Y + ++ILVL+ ++M+ CY ++ ++L +R + Q+ K + + + I+S+F C+ PY F IY ++ +Q+++ + +L + N+ +NP++Y + + R ++R+ + + S +T +N S R R + K + S + + P+ SC + Q P
Sbjct: 170 SVFTLVAISFDRYIAIVHPLKR--RTSRRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKS-------RTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICY-SLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIY-----AYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSNRHTRAETKSQWKR-STMETQIQQAPVTSSCREQRSAQQQQP 444
BLAST of Melanocortin 4 receptor vs. Ensembl Fly
Match: Octbeta1R (gene:FBgn0038980 transcript:FBtr0100322) HSP 1 Score: 61.6178 bits (148), Expect = 7.200e-10 Identity = 60/242 (24.79%), Postives = 109/242 (45.04%), Query Frame = 2
Query: 497 NGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILG----SSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCN--------------IFRKILEFN-----RDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFE 1153
SIM L C+++D Y A+ PL Y +M +R + ++ +VW+ +L SG + + N+ +N I + + Y + + + G I++LS I+ + + K L+ + R I+++ S + +R + T II+S FL C+ P+F + I SL S I+ I F + F NS +NPI+YA+ R+ RA++++ +
Sbjct: 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPG-----IVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD----SCITPRLLVGILFWIGYF----NSALNPIIYAYFNRDFRAAFKKTLK 420
BLAST of Melanocortin 4 receptor vs. Ensembl Fly
Match: Octbeta1R (gene:FBgn0038980 transcript:FBtr0301484) HSP 1 Score: 61.6178 bits (148), Expect = 7.405e-10 Identity = 60/242 (24.79%), Postives = 109/242 (45.04%), Query Frame = 2
Query: 497 NGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILG----SSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCN--------------IFRKILEFN-----RDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFE 1153
SIM L C+++D Y A+ PL Y +M +R + ++ +VW+ +L SG + + N+ +N I + + Y + + + G I++LS I+ + + K L+ + R I+++ S + +R + T II+S FL C+ P+F + I SL S I+ I F + F NS +NPI+YA+ R+ RA++++ +
Sbjct: 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPG-----IVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD----SCITPRLLVGILFWIGYF----NSALNPIIYAYFNRDFRAAFKKTLK 420
BLAST of Melanocortin 4 receptor vs. Ensembl Fly
Match: Octbeta1R (gene:FBgn0038980 transcript:FBtr0331930) HSP 1 Score: 61.2326 bits (147), Expect = 1.024e-9 Identity = 60/242 (24.79%), Postives = 109/242 (45.04%), Query Frame = 2
Query: 497 NGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILG----SSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCN--------------IFRKILEFN-----RDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFE 1153
SIM L C+++D Y A+ PL Y +M +R + ++ +VW+ +L SG + + N+ +N I + + Y + + + G I++LS I+ + + K L+ + R I+++ S + +R + T II+S FL C+ P+F + I SL S I+ I F + F NS +NPI+YA+ R+ RA++++ +
Sbjct: 192 TASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPG-----IVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCD----SCITPRLLVGILFWIGYF----NSALNPIIYAYFNRDFRAAFKKTLK 420
BLAST of Melanocortin 4 receptor vs. Ensembl Zebrafish
Match: mc5rb (melanocortin 5b receptor [Source:ZFIN;Acc:ZDB-GENE-021223-4]) HSP 1 Score: 67.0106 bits (162), Expect = 9.286e-12 Identity = 75/309 (24.27%), Postives = 134/309 (43.37%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLV--------YSLRQTAHN----------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQAS-----QVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
+G ++L +L +L I + P F+CSL +AD +V VS HLL + +RQ + GS+ SL +A+D YV +F+ LRY +M R ++ +W S G I F ++++ T P+ +V LV M+ +++ + R +K A+ IRQ+ ++G T I+L +F+ C++P FF + + +S NI + S F++ L++ NS I+P++YA R +E+R +++ +
Sbjct: 48 LGLISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVS------NAWETIVIHLLANRSLVIEDHFIRQMDNVFDSLICISVVGSMWSLLAIAVDRYVTIFYALRYHNIMTVRRAGILIGSIWTFSTSCG--------IIFIIYSD-----TQPV--------------------VVCLVAMFFAMLLMMASLYSHMFLLARSHVKRMAALPGYNANIRQRASMKGAVTLTILLGIFIVCWAP-FFLHLILMISCPRNIYCVCFMSH----FNMYLILIMCNSVIDPLIYALRSQEMRKTFKEI 312
BLAST of Melanocortin 4 receptor vs. Ensembl Zebrafish
Match: mc2r (melanocortin 2 receptor [Source:ZFIN;Acc:ZDB-GENE-030502-2]) HSP 1 Score: 66.2402 bits (160), Expect = 1.425e-11 Identity = 55/217 (25.35%), Postives = 103/217 (47.47%), Query Frame = 2
Query: 500 GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
GSI S+ +A+D Y+++F LRY LM R +L I+ +W++ G+SG + G+ F I+ IV+ + L+++ Y ++F + +Q +K G+RG T I++ VF++C++P F +++ + I + R+ HV LL+ ++ I+P +YAFR E+R +Y+++
Sbjct: 110 GSIFSILAIAVDRYISIFHALRYHMLMTMRRVLIILFTIWVLC---GTSG--------------------ALMVGF-FEAATVKIF-----FIVLFFTALLLILLLYVHMFLLARHHANRIASMPGAQAQHRKSGLRGALTLTILIGVFVACWAP---FSLHLLIMMICPENPYCECYRSLFQLHV--VLLVSHAVIDPAIYAFRSVELRNTYKKML 292
BLAST of Melanocortin 4 receptor vs. Ensembl Zebrafish
Match: mc1r (melanocortin 1 receptor [Source:ZFIN;Acc:ZDB-GENE-030502-1]) HSP 1 Score: 64.6994 bits (156), Expect = 5.992e-11 Identity = 83/333 (24.92%), Postives = 149/333 (44.74%), Query Frame = 2
Query: 233 QNNISYEN----SDRNV-GI--------LIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLT-------------CLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
NNI+ + SD NV GI L +G ++L +L V+ I + P F+C L +AD +V VS + + LL+ + + H +++ + +A D Y+ +F+ LRY +M + + I+ +VW+ S + SS L F V++ + +++ C + G V LV +A++ Y ++F +R L S+ RQ ++G T I+L VF+ C+ P+F I I ++ +N F H + FL+++ NS I+P++YA+R +E+R + + L
Sbjct: 21 DNNITLNSNSTASDINVTGIAQIMIPQELFLMLGLISLVENILVVVAIIKNRNLHSPMYYFICCLAVADMLVSVSNVVETLFMLLTE-HGLLLVTAKMLQHLDNVIDIMICSSVVSSLSFLCTIAADRYITIFYALRYHSIMTTQRAVGIILVVWLAS--ITSSSL------FIVYHTDNAVIA-------------CLVTFFG----VTLVFTAVL----YLHMFILAHVHSRRITALHKSR--RQTTSMKGAITLTILLGVFILCWGPFFLHLILI-------LTCPTNPYCKCYFSHFNLFLILIICNSLIDPLIYAYRSQELRKTLKEL 314
BLAST of Melanocortin 4 receptor vs. Ensembl Zebrafish
Match: mc5ra (melanocortin 5a receptor [Source:ZFIN;Acc:ZDB-GENE-021223-3]) HSP 1 Score: 62.003 bits (149), Expect = 4.590e-10 Identity = 77/311 (24.76%), Postives = 131/311 (42.12%), Query Frame = 2
Query: 266 NVGILIFFI-GSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLV--YSLRQTAHN----------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIK----LQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
N+ +F I G ++L +L + I + P F+CSL +AD +V VS + L+V + +RQ + S+ SL +A+D YV +F+ LRY +M R I+ +W FC G FI IY IV LV IM+ +++ + R +K L I Q+ ++ T I+L +F+ C++P FF + + +S N+ + S F++ L++ NS I+P++YAFR +E+R + + +
Sbjct: 42 NIATEVFLILGIVSLLENILVICAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETIVIYLLTNRQLVVEDHFIRQMDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAALIIGGIW----------------TFCT------------GCGIVFI-----IYSDNTSVIVCLVSMFFIMLALMASLYSHMFMLARSHVKRIAALPGYNSIHQRASMKAAVTLTILLGIFIVCWAP-FFLHLILMISCPRNLYCMCFMSH----FNMYLILIMCNSVIDPLIYAFRSQEMRKTLKEI 314
BLAST of Melanocortin 4 receptor vs. Ensembl Zebrafish
Match: mc5ra (melanocortin 5a receptor [Source:ZFIN;Acc:ZDB-GENE-021223-3]) HSP 1 Score: 61.6178 bits (148), Expect = 5.992e-10 Identity = 77/311 (24.76%), Postives = 131/311 (42.12%), Query Frame = 2
Query: 266 NVGILIFFI-GSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLV--YSLRQTAHN----------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIK----LQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
N+ +F I G ++L +L + I + P F+CSL +AD +V VS + L+V + +RQ + S+ SL +A+D YV +F+ LRY +M R I+ +W FC G FI IY IV LV IM+ +++ + R +K L I Q+ ++ T I+L +F+ C++P FF + + +S N+ + S F++ L++ NS I+P++YAFR +E+R + + +
Sbjct: 30 NIATEVFLILGIVSLLENILVICAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETIVIYLLTNRQLVVEDHFIRQMDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAALIIGGIW----------------TFCT------------GCGIVFI-----IYSDNTSVIVCLVSMFFIMLALMASLYSHMFMLARSHVKRIAALPGYNSIHQRASMKAAVTLTILLGIFIVCWAP-FFLHLILMISCPRNLYCMCFMSH----FNMYLILIMCNSVIDPLIYAFRSQEMRKTLKEI 302
BLAST of Melanocortin 4 receptor vs. Ensembl Xenopus
Match: MC3R (melanocortin 3 receptor [Source:HGNC Symbol;Acc:HGNC:6931]) HSP 1 Score: 67.781 bits (164), Expect = 7.421e-12 Identity = 77/299 (25.75%), Postives = 144/299 (48.16%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS-----LIAAEMKKTPGPCFHLLVY------SLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNY--SRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
+G ++L +L +L I + P FLCSL +AD +V VS ++ A K +LL + S+ + SI +L +AID Y+ +F+ LRY +M + + ++ ++W SCI+ I F V++ + +++ C I + F T+++L+ + + ++ + + K + L V++Q+ ++G T I+L VF+ C++P+F L I IS SN T +F+ L++ NS I+P++YAFR E+R +++ +
Sbjct: 43 LGIISLLENILVILAILKNKNLHSPMYFFLCSLAVADMLVSVSNALETIVIAIQNKYLVIGDYLLQHLDDVFDSMICISLVASICNLLVIAIDRYITIFYALRYHSIMTVKKAIALIVVIW-TSCIIC-------GIVFIVFSESKTVIV-------CLI--------TMFFTMLVLMATMYVHMFLFARLHVKRIA------ALPVDGVVQQRTCMKGAITITILLGVFVVCWAPFF-------LHLILIISCPSNSYCVCYTSYFNTYLILIMCNSIIDPLIYAFRSLEMRKTFKEI 305
BLAST of Melanocortin 4 receptor vs. Ensembl Xenopus
Match: MC4R (melanocortin 4 receptor [Source:NCBI gene;Acc:100486677]) HSP 1 Score: 64.3142 bits (155), Expect = 1.134e-10 Identity = 71/299 (23.75%), Postives = 133/299 (44.48%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS-----LIAAEMKKTPGPCFHLLVY------SLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
+G ++L +L + I+ + P F+CSL +AD +V VS ++ T H++V S+ ++ SI SL +A+D Y +F+ L+Y ++ R + I+S +W I G + Y +++ + I+ C I I+ +M Y ++F + L + +RQ ++G T I+L VF++C+SP+F L IF +S N H + +L+++ NS I+P++YA R +E+R +++ +
Sbjct: 48 LGIVSLMENILVIAAISRNKNLHSPMYFFICSLAVADMLVSVSNGFETVVITLFNTTDKNTQHIIVNVDNILDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIITVRRAVVIISCIWTACSISGVLFIIY-------YDSAVVII----------------------CLISIIFTMLALMASLYVHMFMLARLHIKRIAVLPGTNSVRQVTNMKGAITLTILLGVFVACWSPFF-------LHLIFYVSCPRNPYCVCFMSHFNIYLILIMCNSVIDPLIYALRSQELRKTFKEM 310
BLAST of Melanocortin 4 receptor vs. Ensembl Xenopus
Match: pprc1 (peroxisome proliferator-activated receptor gamma, coactivator-related 1 [Source:Xenbase;Acc:XB-GENE-6469512]) HSP 1 Score: 63.5438 bits (153), Expect = 1.773e-10 Identity = 75/331 (22.66%), Postives = 138/331 (41.69%), Query Frame = 2
Query: 197 LTDISEIFRLINQNNISYENSDRNVGILIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMA-----------DTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
L +I IF +I N+ + FF+ SLA+ L++V + +W+ + N+ L+M D+M+C+S++A S+ SL +A+D YV +F+ LRY +M R I++ +W FC G FI + Y S + C I + +M+ Y ++F + L + Q+ ++G T I+L +F+ C++P FF + + +S N+ + S F++ L++ NS I+P++YAFR +E+R +++ +
Sbjct: 52 LENILVIFAIIKNKNLHSP--------MYFFVCSLAVADMLVSV---SNAWETITINLINNRHLIMEETFVRHIDNVFDSMICISVVA-------------------------SMCSLLAIAVDRYVTIFYALRYHNIMTMRRAGIIIACIW----------------TFCT------------GCGIIFILY----YESTYVIICLITMFFTMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVHQRTSMKGAITLTILLGIFIVCWAP-FFLHLILMISCPQNLYCVCFMSH----FNMYLILIMCNSVIDPMIYAFRSQEMRKTFKEI 309
BLAST of Melanocortin 4 receptor vs. Ensembl Xenopus
Match: ctu2 (cytosolic thiouridylase subunit 2 [Source:Xenbase;Acc:XB-GENE-5732028]) HSP 1 Score: 62.3882 bits (150), Expect = 5.530e-10 Identity = 72/277 (25.99%), Postives = 124/277 (44.77%), Query Frame = 2
Query: 374 FLCSLVMADTMVCVSLIAAEMKKTPGPC--FH--LLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTN-----PMAQGYCF----IQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKI-LEFNRDFIKLQASQVIRQ--KRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLI-MNSFINPILYAFRLREIRASYRRLFE 1153
F+ SL AD V V I + + G C FH L + SI SL +A D Y+A+ PLRY L+ R I+++ W++S ++G + + W+ + N PM + C + D +Y + F ++I + L+M+ Y IF + + +K+ + R +R V + II+ +F C+ P + T+F Q N R ++ + LL NS +NP++YA+R+RE R ++R++
Sbjct: 50 FVVSLAAADIAVGVLAIPFAIAISTGFCATFHACLFIACFVLVLTQSSIFSLLAIAADRYIAIRIPLRYNSLVTSRRANAIIAVCWLLSFVIGLTPMLG-------WHKEVPPSGNTTCRSPMIE--CLFENVVTMDYMVYYNFFACVLIPL---LLMLGIYLRIFMAARHQLKQMKMKVTCGERSRSTLQREVHAAKSLAIIVGLFALCWLPLHIINCF----TLF--CQACN--RPPLWIMYTAILLSHANSVVNPLIYAYRIREFRHTFRKILH 306
BLAST of Melanocortin 4 receptor vs. Ensembl Xenopus
Match: MC1R (melanocortin 1 receptor [Source:HGNC Symbol;Acc:HGNC:6929]) HSP 1 Score: 61.6178 bits (148), Expect = 8.455e-10 Identity = 51/218 (23.39%), Postives = 100/218 (45.87%), Query Frame = 2
Query: 515 LTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIR----QKRG-VRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
L +AID Y+ +F+ LRY +M R ++ + ++W +S + + F V++ + +++ C IV + +M+ Y ++F + R LQ + R Q R ++G T ++L VF C+ P F L +S ++ N+ F++ + +LL++ NS I+P++YAFR +E+R + + +
Sbjct: 134 LGAIAIDRYITIFYALRYHSIMTLRRVVIAIGVIWSVSLVCAAI--------FIVYHESRAVI---------------------LCLIVFFLFMLALMVALYIHMFALARQHARSISALQKGKSRRITPHQARANMKGAITLTLLLGVFFLCWGPLF-------LHLTLFVSCPGHHICNSYFYYFNIYLLLVICNSVIDPLIYAFRSQELRKTLKEI 315
BLAST of Melanocortin 4 receptor vs. Ensembl Mouse
Match: Mc4r (melanocortin 4 receptor [Source:MGI Symbol;Acc:MGI:99457]) HSP 1 Score: 67.0106 bits (162), Expect = 1.110e-11 Identity = 72/302 (23.84%), Postives = 140/302 (46.36%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS-------LIAAEMKKTPGPCFHL----LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRLFEF 1156
+G ++L +L ++ IA + P F+CSL +AD +V VS + T F + ++ S+ ++ SI SL +A+D Y +F+ L+Y +M R + I+S +W + G + F +++++ +++ C I S F T+++L+ S Y ++F + L + IRQ ++G T I++ VF+ C++P+F L +F IS N H + +L+++ N+ I+P++YA R +E+R +++ + F
Sbjct: 54 LGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSG--------VLFIIYSDSSAVII-------CLI--------SMFFTMLVLMASL------YVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFF-------LHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICF 319
BLAST of Melanocortin 4 receptor vs. Ensembl Mouse
Match: Mc5r (melanocortin 5 receptor [Source:MGI Symbol;Acc:MGI:99420]) HSP 1 Score: 62.7734 bits (151), Expect = 3.233e-10 Identity = 69/303 (22.77%), Postives = 134/303 (44.22%), Query Frame = 2
Query: 284 FFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADT-----------MVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQAS----QVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
FF+GSLA+ L++ ++ +W+ + + LV+ADT M+C+S++A S+ SL +A+D Y+ +F+ LRY +M R I++ +W FC+ + G FI IY I+ L+ M++ +++ + R+ +K A+ +RQ+ ++G T ++L +F+ C+SP FF + + +S N+ S +F++ L++ NS I+P++YA R +E+R +++ +
Sbjct: 120 FFVGSLAVADMLVS---MSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVA-------------------------SMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIW----------------TFCI------------SCGIVFI-----IYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSP-FFLHLILMISCPQNVYCSCFMS----YFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEI 356
BLAST of Melanocortin 4 receptor vs. Ensembl Mouse
Match: Mc3r (melanocortin 3 receptor [Source:MGI Symbol;Acc:MGI:96929]) HSP 1 Score: 58.9214 bits (141), Expect = 5.074e-9 Identity = 61/253 (24.11%), Postives = 109/253 (43.08%), Query Frame = 2
Query: 398 DTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFR-KILEFNRDFIKLQASQVIRQKRG-VRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
D+M+C+SL+A SI +L +AID YV +F+ LRY +M R L ++ ++W+ I G + F +++ + ++ C I + L+M Y ++F L R + A V Q+ ++G T I+L VF+ C++P FF + + ++ N I T F+ L++ NS I+P++YAFR E+R +++ +
Sbjct: 121 DSMICISLVA-------------------------SICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICG--------VMFIIYSESKMVIV---------------------CLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAP-FFLHLVLIITCPTNPYCIC----YTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEIL 314
BLAST of Melanocortin 4 receptor vs. Ensembl Mouse
Match: Adora2b (adenosine A2b receptor [Source:MGI Symbol;Acc:MGI:99403]) HSP 1 Score: 57.7658 bits (138), Expect = 9.914e-9 Identity = 78/315 (24.76%), Postives = 131/315 (41.59%), Query Frame = 2
Query: 251 ENSDRNVGILIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPC--FH--LLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVIL-----------VLSA-LIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
E D L I +LA+ +L + S P FL SL AD V + I + + G C FH L + SI SL +A+D Y+A+ PLRY L+ I++++W+++ +G + F WN+ S +N G C F +V + VL LIM+ Y IF + + + S+ Q R + + +I+ +F C+ P I+ T+F+ + + + + +V+ L NS +NPI+YA+R R+ R S+ ++
Sbjct: 4 ETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLT-------PFLGWNSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQLQRMELMDHSRTTLQ-REIHAAKSLAMIVGIFALCWLPVH----AINCITLFHPALAKDKPKWVM--NVAILLSHANSVVNPIVYAYRNRDFRYSFHKI 304
BLAST of Melanocortin 4 receptor vs. Ensembl Mouse
Match: Nmur2 (neuromedin U receptor 2 [Source:MGI Symbol;Acc:MGI:2441765]) HSP 1 Score: 57.7658 bits (138), Expect = 1.558e-8 Identity = 83/315 (26.35%), Postives = 132/315 (41.90%), Query Frame = 2
Query: 278 LIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKT----P---GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISI-------VTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQV-IRQKRGVRGLTTTL--IILSVFLSCFSPY--------FFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
LIF +G + LL LVIA P +L SL ++D +V + + E+ + P GP +L +T SI+S+T ++I+ YVA+ P R RR L I+S+VW S + I F + N S+ VT P+ W N + ++ LI + Y R RD L+A +V + R R T + +++ VF C++P+ F E SL+ +FN+ + VSG ++S +NPI+Y R RA++R +
Sbjct: 46 LIFVVGVIG---NLLVCLVIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQQFPNGSSVPGSATCTVTKPI--------WVYNFIIQATSFLFYILPMTLISVLYYLMGLR----LKRD-ESLEADKVTVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVDEWTESLAAVFNLIHV-----------VSGVFFYLSSAVNPIIYNLLSRRFRAAFRNV 333
BLAST of Melanocortin 4 receptor vs. UniProt/SwissProt
Match: sp|P56451|MC5R_BOVIN (Melanocortin receptor 5 OS=Bos taurus OX=9913 GN=MC5R PE=3 SV=1) HSP 1 Score: 74.3294 bits (181), Expect = 2.391e-13 Identity = 75/305 (24.59%), Postives = 128/305 (41.97%), Query Frame = 2
Query: 284 FFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMAD-----------TMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRLFEFQ 1159
FF+GSLA+ L++ ++ SW+ + + LVMAD +M+C+S++A S+ SL +A+D YV +F LRY +M R I+ +W G+ + Y + V C I + + L+M Y ++F R L +RQ+ GV+G T ++L VF+ C++P+F L I IS N + H + +L+++ NS I+P++YAFR +E+R +++ + FQ
Sbjct: 73 FFVGSLAVADMLVS---LSNSWETITIYLLTNKHLVMADASVRHLDNVFDSMICISVVA-------------------------SMCSLLAIAVDRYVTIFCALRYQRIMTGRRSGAIIGGIWAFCASCGTVFIVYYESTYVV-----------------------------ICLIAMFLTMLLLMASLYTHMFLLARTHIRRIATLPGHSSVRQRTGVKGAITLAMLLGVFIVCWAPFF-------LHLILMISCPHNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQ 313
BLAST of Melanocortin 4 receptor vs. UniProt/SwissProt
Match: sp|P41983|MC5R_SHEEP (Melanocortin receptor 5 OS=Ovis aries OX=9940 GN=MC5R PE=3 SV=1) HSP 1 Score: 72.7886 bits (177), Expect = 1.003e-12 Identity = 81/317 (25.55%), Postives = 138/317 (43.53%), Query Frame = 2
Query: 260 DRNVGI-LIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMAD-----------TMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRLFEFQ 1159
+RN+ I + FF+GSLA+ L++ ++ W+ + + LVMAD +M+C+S++A S+ SL +A+D YV +F LRY +M R I++ +W FC + G FI + Y S + C I + + L+M Y ++F R L +RQ+ GV+G T ++L VF+ C++P+F L I IS N + H + +L+++ NS I+P++YAFR +E+R +++ + FQ
Sbjct: 64 NRNLHIPMYFFVGSLAVADMLVS---LSNFWETITIYLLTNKHLVMADASVRHLDNVFDSMICISVVA-------------------------SMCSLLAIAVDRYVTIFCRLRYQRIMTGRRSGAIIAGIW----------------AFCT------------SCGTVFIVY----YESTYVVVCLIAMFLTMLLLMASLYTHMFLLARTHVRRIAALPGHSSVRQRTGVKGAITLAMLLGVFIICWAPFF-------LHLILMISCPQNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQ 313
BLAST of Melanocortin 4 receptor vs. UniProt/SwissProt
Match: sp|Q0Z8I9|MC4R_VULVU (Melanocortin receptor 4 OS=Vulpes vulpes OX=9627 GN=MC4R PE=3 SV=1) HSP 1 Score: 68.5514 bits (166), Expect = 2.629e-11 Identity = 70/299 (23.41%), Postives = 133/299 (44.48%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS-------LIAAEMKKTPGPCFHL----LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
+G ++L +L ++ IA + P F+CSL +AD +V VS + T F + ++ S+ ++ SI SL +A+D Y +F+ L+Y +M R + I+S +W + G I F +++++ +++ C I + +M Y ++F + L + IRQ ++G T I++ VF+ C++P+F L IF IS N H + +L+++ NS I+P++YA R +E+R +++ +
Sbjct: 54 LGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSG--------ILFIIYSDSTAVI---------------------ICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFF-------LHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEI 316
BLAST of Melanocortin 4 receptor vs. UniProt/SwissProt
Match: sp|O97504|MC4R_PIG (Melanocortin receptor 4 OS=Sus scrofa OX=9823 GN=MC4R PE=2 SV=1) HSP 1 Score: 68.1662 bits (165), Expect = 3.392e-11 Identity = 68/299 (22.74%), Postives = 134/299 (44.82%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS-------LIAAEMKKTPGPCFHL----LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
+G ++L +L ++ IA + P F+CSL +AD +V VS + T F + ++ S+ ++ SI SL +A+D Y +F+ L+Y +M + + I+S +W + + G + F +++++ +++ C I + +M Y ++F + L + IRQ ++G T I++ VF+ C++P+F L IF IS N H + +L+++ NS I+P++YA R +E+R +++ +
Sbjct: 54 LGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAVCTVSG--------VLFIIYSDSSAVI---------------------ICLITVFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFF-------LHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEI 316
BLAST of Melanocortin 4 receptor vs. UniProt/SwissProt
Match: sp|Q9MZV8|MC5R_PIG (Melanocortin receptor 5 (Fragment) OS=Sus scrofa OX=9823 GN=MC5R PE=3 SV=1) HSP 1 Score: 67.3958 bits (163), Expect = 3.771e-11 Identity = 76/311 (24.44%), Postives = 133/311 (42.77%), Query Frame = 2
Query: 236 NNISYENSDRNVGILIFF-IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS---------LIA-AEMKKTPGPCFHL--LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLRE 1123
N S D + + +F +G ++L +L + IA + +P F+CSL +AD +V +S LIA + + HL + S+ + S+ SL +A+D YV +F+ LRY LM R I++ +W + G + Y + V C + + + L+M Y ++F + R L + RQ+ ++G T ++L VF+ C++P+F L I IS N + H + +L+++ NS I+P++YAFR +E
Sbjct: 19 GNTSSPCEDMGIEVEVFLTLGLISLLENILVIGAIARNKNLHVPMYFFVCSLAVADMLVSLSNSWETITIYLIANKHLVLSDTSVRHLDNVFDSMICISLVASMCSLLAVAVDRYVTIFYALRYQHLMTGRRCGAIIAGIWALCTGCGPVFIVYYESTYVV-----------------------------VCLVAMFLTMLLLMASLYAHMFLQARAHVRRIAALPGYRSARQRTSMKGAVTLAMLLGVFIVCWAPFF-------LHLILMISCPQNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQE 293
BLAST of Melanocortin 4 receptor vs. TrEMBL
Match: A0A0L8HQC9 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22008667mg PE=4 SV=1) HSP 1 Score: 95.1301 bits (235), Expect = 1.562e-17 Identity = 72/314 (22.93%), Postives = 149/314 (47.45%), Query Frame = 2
Query: 260 DRNVGILIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEM-------------KKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNY---SRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFE 1153
DR + I++ + +A L ++ ++ N + + SL+M+D + + + A + + C + +V +L + ++++L +A+D Y+A+ PL++ LM+RR + +++ VW++ + G S P F N N YC C ++ F +++L M++ Y +F I ++ +LQ +R +GL TT+IIL ++ C+ PY E+ +++ + N+ + NY S+ ++ + L+ +NS +P++YA R+ +++ SYRRL
Sbjct: 40 DRLIAIILCIVAIIANAVSLFAIMQFKGTFTA---NKQLVTSLLMSDLFISLCFLTASLTNNNNFMFPVEGEDEGKSICIYAVVEALMISGQLTNLLNLAAMALDHYIAINIPLKHSYLMDRRHVGILIAGVWVLGSLCGFSDFLLP---FTPLYKN---CRNQKFLNYC-DTIKCTMFEPNFVLFAVVILCLFEMVFLYSQVFITIYKYP----QLQTRHAPNIRRNNKGLVTTIIILLSYIICWLPYCLMELTMTIVSATNLPDMINYYQISQKAQYYLYN--LIALNSIFDPLIYAIRMPDMQNSYRRLLR 337
BLAST of Melanocortin 4 receptor vs. TrEMBL
Match: R7VBJ0 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_200128 PE=4 SV=1) HSP 1 Score: 81.2629 bits (199), Expect = 9.108e-13 Identity = 79/316 (25.00%), Postives = 150/316 (47.47%), Query Frame = 2
Query: 260 DRNVGILIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKT--------PGP--------CFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMN-RRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIY--ISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
R +L + A+ + L++L I+ +L +++ + SL +D ++ +S+I K GP C + V +L T+ N ++ +L +A D Y+A+ PL + +M+ RR+ L ++S+ W IS + G S Y + +S T +C + + + Y + T I ++ + M++CY I +I + + + ++ K RGL TTL+I+ F+ C+ P F++ I + T +N S + ++ T L ++N+ +PI+YA R+ E++ YRRLF
Sbjct: 45 SRPASVLAIVLVIFAVLANALSLLAISQVRMRLTGHLRLVLSLASSDLLIGISVILFLFNKVIYQYFQPGEGPRHCRRRFWCVFVFVKALNSTSLNMTLFNLMAMAADHYLAILRPLHHQSMMSKRRSKLLLISL-WTISVVAGFSDYLYAIPKY---KRVVSRFT------FCEVVY-LSPYNEEYLTFGISFVAFVQMLYCYIRICVRIKQREKCMLVRTNGLHVQLKYNTRGLITTLLIVGTFVLCWLPMCLFQVALIIKVKTDYN-SVVPLLAKLTTIDQYLYDLHLINAICDPIIYAVRMSEVKLGYRRLF 348
BLAST of Melanocortin 4 receptor vs. TrEMBL
Match: K1RDJ9 (Sphingosine 1-phosphate receptor 1 OS=Crassostrea gigas OX=29159 GN=CGI_10022192 PE=4 SV=1) HSP 1 Score: 81.6481 bits (200), Expect = 1.131e-12 Identity = 77/313 (24.60%), Postives = 141/313 (45.05%), Query Frame = 2
Query: 299 LALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSL-------------IAAEMKKTP----GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFY--------PSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQI----SNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
LAL +L++ A L + K + SL ++D +V +S+ I M K C V S+ TAH S+++L +A+D Y++V PL Y +MN +++I+W+I+ I G S F +NFC + ++ T Y++ + I++ ++ + ++ Y I+R++ + N + L + K+ R TTL+I+ F+ C+ P F++ + + N + S R + + LL++NS +PI+YA RL+E++ Y RL
Sbjct: 106 LALAVNILSIAATAHIPHGLTHHSKLIISLAVSDILVTLSVFMHILIKVLVAPVIPPTMDKMEERLTSACMFQFVNSINITAHLISLLNLYAMALDHYISVMQPLHYYHIMNNFRGNLMITILWVIAVIGGFSNFFAGFGKTQKDSFVNFCEY----TLYTE---------------YQAEYIVIIMALICLVSILVIYIRIYREVKQINAKCVTL-LKDGLHNKKAFR---TTLLIIGTFVVCWLPSMTFQLAMIIQVHVNTESVRKLFSTLIRANKYLYA---LLLVNSLCDPIIYAVRLKEVQHGYFRLL 392
BLAST of Melanocortin 4 receptor vs. TrEMBL
Match: A0A402EG94 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Paroedura picta OX=143630 GN=parPi_0002716 PE=3 SV=1) HSP 1 Score: 79.337 bits (194), Expect = 1.603e-12 Identity = 93/349 (26.65%), Postives = 147/349 (42.12%), Query Frame = 2
Query: 209 SEIFRLINQNNIS-YEN-SDRNVGI-----------LIFFIGSLALTSQLLTVLVIAFSWKK---LLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHN-------------------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
SEI RL++Q NI EN S+ V I + F I L + LL ++ + WKK P F+CSL ++D + + KT F +L T GSI SL+ +A D Y+ +F+ LRY +M + L I+ ++W+ G + + + V + +I + GF + IL L Y ++F R I L + I Q+ ++G T I+L VFL C++P+ + ++ N + S FHV+G L++ N I+P++YAFR E+R S+RRLF
Sbjct: 7 SEIIRLVSQKNIHPSENISEFPVNITDCTQIIMPEEVFFTIAFLGIVENLLVLIAV---WKKKNLHSPMYVFICSLAVSDML-------GSLYKTLENIFIILCKKRYLTCQEDFEKVVDDVIDFMFILSLLGSIFSLSAIAADRYITIFYALRYHNIMTLQRALIILVVIWVFCAGSGIAMVIFSHETATVLSFSILL---------------------GFMLVFILCL--------YIHMFLLAHSHARK-IALLPTSTIHQRANMKGAITLTILLGVFLCCWAPFVLHMLLMTFCP-HNPYCVCYQS----IFHVNGILIMCNGVIDPMIYAFRSPELRNSFRRLF 310
BLAST of Melanocortin 4 receptor vs. TrEMBL
Match: A0A5N3XWJ3 (Uncharacterized protein (Fragment) OS=Muntiacus reevesi OX=9886 GN=FD755_009681 PE=4 SV=1) HSP 1 Score: 78.5666 bits (192), Expect = 3.640e-12 Identity = 79/308 (25.65%), Postives = 132/308 (42.86%), Query Frame = 2
Query: 284 FFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMAD-----------TMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGF---CTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRLFEFQ 1159
FF+GSLA+ L++ ++ SW+ + + LVMAD +M+C+S++A S+ SL +A+D YV +F+ LRY +M R I++ +W FC I IV Y S + C I + + L+M Y ++F R L +RQ+ GV+G T ++L VF+ C++P+F L I IS N + H + +L+++ NS I+P++YAFR +E+R +++ + FQ
Sbjct: 81 FFVGSLAVADMLVS---LSNSWETITIYLLTNKHLVMADASVRHLDNVFDSMICISVVA-------------------------SMCSLLAIAVDRYVTIFYALRYQRIMTGRRSGAIIAGIW----------------AFCTSCGTIFIVY----------------YESTYVIVCLIAMFLTMLLLMASLYTHMFLLARTHVRRIAALPGHSSVRQRTGVKGAVTLAMLLGVFIVCWAPFF-------LHLILMISCPQNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIICFQ 321
BLAST of Melanocortin 4 receptor vs. Ensembl Cavefish
Match: MC4R (melanocortin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6932]) HSP 1 Score: 68.5514 bits (166), Expect = 2.841e-12 Identity = 74/301 (24.58%), Postives = 138/301 (45.85%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS----------LIAAEMKKTPGPCFHL--LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRLF 1150
+G ++L +L + IA + P F+CSL +AD +V VS + + + G ++ + S+ ++ SI SL +A+D Y+ +F+ LRY ++ R L ++S +W + G + F V++ + +++ C I S F T++ L+ S Y ++F + L IRQ+ ++G T I+L VF+ C++P+F L I I+ N H + +L+++ NS I+P++YAFR E+R +++ +F
Sbjct: 57 LGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNASETIVIALISGGNVSISAGVIRNMDNIFDSMICSSLLASICSLLAIAVDRYITIFYALRYHHIVTVRRTLAVISCIWACCTVSG--------VLFIVYSESTTVLV-------CLI--------SMFFTMLALMASL------YVHMFLLARLHIKRIAALPGHAPIRQRANMKGAVTLTILLGVFVVCWAPFF-------LHLILMITCPRNPYCACFMSHFNMYLILIMCNSVIDPLIYAFRSHEMRKTFKEIF 321
BLAST of Melanocortin 4 receptor vs. Ensembl Cavefish
Match: taar10b (trace amine-associated receptor 10b [Source:ZFIN;Acc:ZDB-GENE-041014-67]) HSP 1 Score: 65.855 bits (159), Expect = 2.152e-11 Identity = 79/310 (25.48%), Postives = 135/310 (43.55%), Query Frame = 2
Query: 269 VGILIFFIGSLALT--SQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHL------LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVL----SALIMIWCYCNIFR------KILEFNRDFIKLQASQVIRQKRGVRGLTTTL-IILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYR 1141
V + IFF S LT LL ++ + + P + SL +AD +V ++ M ++ C++L + SL T SI++L +++D Y AV PL Y M T +F++ + W IS ++G G+ + +N + N N + +G C ++++ +V +L AL+M+ Y I + + IK A + + R T TL II+ VFLS + P+F I + YS + F + ++ NS NPI+YAF R +++
Sbjct: 52 VVLYIFFSASSLLTVIGNLLVIITVIHFKQLHTPTNYLIVSLAVADLLVGGVVMPPSMLRSVETCWYLGSIFCKIHSSLDVTVCTASILNLCIISLDRYYAVCHPLLYHSKMTPNTTVFMIFVCWTISVLVGF-GMIFLELN--ILGNEDFYYNNFVCEG------SCTVFQAKVGALVFSMLCFYIPALVMLSVYVKILHTARRQARAIHSTNTHIKNTAEEKANINKSERKATKTLAIIMGVFLSFWVPFFLCNC---------IDPFTGYSVPPLLFDLFLWVGYFNSTCNPIVYAFFYSWFRHAFK 343
BLAST of Melanocortin 4 receptor vs. Ensembl Cavefish
Match: ENSAMXT00000026447.2 (pep primary_assembly:Astyanax_mexicanus-2.0:3:55413204:55414361:-1 gene:ENSAMXG00000025721.2 transcript:ENSAMXT00000026447.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 61.6178 bits (148), Expect = 5.718e-10 Identity = 68/273 (24.91%), Postives = 116/273 (42.49%), Query Frame = 2
Query: 374 FLCSLVMADTMVCVSLIA---AEMKKTPGPCFHL----LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSAL-IMIWCYCNIFRKI------LEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
FL SL +AD VCV +A A + T P +L L+ S+ SI SL +A++ YVA+F P RY LM R L ++ + W+++ ++G P + W+ P GYCF ++ + VL+ L +M Y IF + + R A K+ ++ T+ ++L +F C+ P ++ L + + I H NS +NP LYA++++ R +++ +F
Sbjct: 125 FLVSLAVAD--VCVGALAIPCAILTDTGIPHNNLYLCLLMLSVLIMLTQSSIFSLLAVAVERYVAIFMPFRYHSLMTPRNALLVILVTWVLAFLIG----LVPIMG---WHK------TPPDSGYCFFVLVVDMTYMVYFNFFACVLTPLVVMFLIYAQIFVTVKHQVRRIAAERGVAGGGADGAANIKKEMKTATSLFLVLFLFTVCWIPLHVINCFLLLCPTCPV-PLPLLLTAIILSHA-------NSAVNPFLYAYKMKSFREAFKGIF 374
BLAST of Melanocortin 4 receptor vs. Ensembl Cavefish
Match: mc5ra (melanocortin 5a receptor [Source:ZFIN;Acc:ZDB-GENE-021223-3]) HSP 1 Score: 60.4622 bits (145), Expect = 1.188e-9 Identity = 76/317 (23.97%), Postives = 128/317 (40.38%), Query Frame = 2
Query: 266 NVGILIFFI-GSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS----------------LIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIK----LQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIM--NSFINPILYAFRLREIRASYRRL 1147
N+ +F I G ++L +L + I + P F+CSL +AD +V VS ++ + F S+ + S+ SL +A+D YV +F+ LRY +M R I++ +W FC G FI IY IV LV IM+ +++ + R +K L I Q+ ++ T I+L +F+ C++P+F L I IS N H + +L+++ NS I+P++YAFR +E+R + + +
Sbjct: 34 NIATEVFLILGIISLLENILVICAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETIIIYLLNNQQLVVEDHFIRQMDNVFD----SMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAALIIAGIW----------------TFCT------------GCGIVFI-----IYSDSTPVIVCLVSMFFIMLALMASLYSHMFMLARSHVKRIAALPGYNSIHQRASMKAAITLTILLGIFIVCWAPFF-------LHLILMISCPRNLYCMCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTLKEI 306
BLAST of Melanocortin 4 receptor vs. Ensembl Cavefish
Match: mc5rb (melanocortin receptor 5-like [Source:NCBI gene;Acc:103042566]) HSP 1 Score: 60.077 bits (144), Expect = 1.737e-9 Identity = 74/310 (23.87%), Postives = 129/310 (41.61%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPCFHLLV--------YSLRQTAHN----------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQAS-----QVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
+G ++L +L +L I + P F+CSL +AD +V VS HLL + +RQ + S+ SL +A+D YV +F+ LRY +M R I+ +W +FC G FI IY +V LV M+ +++ + R ++ A+ I+Q ++G T I+L +F+ C++P FF + + +S N+ I S F++ L++ NS I+P++YA R +E+R +++ +
Sbjct: 54 LGLVSLLENILVILAIVKNTNLHSPMYFFICSLAVADMLVSVS------NAWETIVIHLLANRRLVVEDHFIRQLDNVFDSLICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGMIIGSIW----------------SFCT------------GCGIIFI-----IYSDTTPVVVCLVAMFFGMLLLMASLYSHMFLLARSHVRRMAALPGYNASIQQWSSMKGAITLTILLGIFIVCWAP-FFLHLILMISCPRNLYCICFMSH----FNMYLILIMCNSVIDPLIYALRSQEMRKTFKEIL 319
BLAST of Melanocortin 4 receptor vs. Ensembl Sea Lamprey
Match: mc5ra (melanocortin 5a receptor [Source:ZFIN;Acc:ZDB-GENE-021223-3]) HSP 1 Score: 63.5438 bits (153), Expect = 1.395e-11 Identity = 74/305 (24.26%), Postives = 125/305 (40.98%), Query Frame = 2
Query: 290 IGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVS---------LIAAEMKKTPGPCFHLLVYSLRQTAHN-----------GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRG---VRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISN-YSRNTI-FFHVSGFLLIMNSFINPILYAFRLREIR 1129
+G ++L L + IA + P F+CSL +AD +VC+S L+ P P + Q N S+ +L +A+D Y +F+ L+Y ++ R +++ VW + G+ + Y W++ IV C I + V ++M Y ++F R S Q+ G ++G T I+L VF+ C++P+F L F IS +N Y I +F + L+++NS I+P++YAFR E+R
Sbjct: 15 LGIVSLVENALVIAAIARNRNMHSPMYCFICSLAVADLLVCLSNAWETIAIALVHGRHVHIPAP--------ILQHVDNVFDSFICISVVASMCNLLAIAVDRYXTIFYALQYHSIVTMRRAAVVIACVWAACVVSGTLFITY-------WDHRAVIV----------------------CLIALFVTMLVLMASLYAHMFALARSHARRISAQPRSSRQGQQHGAASLKGAVTLSILLGVFVFCWAPFF-------LHLTFIISCPANPYCCAYIAYFPLYLLLIMINSVIDPLIYAFRSPELR 275
BLAST of Melanocortin 4 receptor vs. Ensembl Sea Lamprey
Match: TAAR1 (trace amine associated receptor 1 [Source:HGNC Symbol;Acc:HGNC:17734]) HSP 1 Score: 62.003 bits (149), Expect = 7.223e-11 Identity = 84/329 (25.53%), Postives = 144/329 (43.77%), Query Frame = 2
Query: 239 NISYENSDRNVGILIFFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLC-SLVMADTMVCVSLIAAEMKKTPGPCFHL------LVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWN--NNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFR-------------KILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQ 1159
++SY + G+L+FFI S L + L+ +I F K+L + L SL AD +V + ++ M +T C+ L SL SI+ L+C+A D YVA+ PL Y + T+ F++ + W +C L F S WN +V + + C I N++ + T + IMI Y I+R L+ NRD + Q + + R+ + L II+ FL + P F + I ++++ + + +++ +L +NS INP+LYA R R +++ +F +
Sbjct: 23 HLSYTHGLVVQGVLLFFIISTILGNMLVIASIIYF--KQLQSHTNSLTLSLAAADLLVGLVVMPFSMMRTVHSCWFYGKLLCKLHCSLDYIFSTVSILHLSCVAFDRYVAICDPLHYTSRVTNNTVAFMLILCW--TCPLVYFAPFLLS-----WNIIGIEEMVQSRICADTCAIV--KNVWFAYVDTCCAFITPMAIMITTYVKIYRVARRQARQVSAASVALQLNRDERQNQWALMKREHNATKTLG---IIMGGFLFFWLPNFVASL---------IDPVNDFQTDPLVWNIVVWLGYINSTINPLLYASFNRPFRKAFKIMFSLE 328
BLAST of Melanocortin 4 receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010558.1 (pep scaffold:Pmarinus_7.0:GL477661:10193:14261:1 gene:ENSPMAG00000009564.1 transcript:ENSPMAT00000010558.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 57.7658 bits (138), Expect = 1.664e-9 Identity = 76/274 (27.74%), Postives = 125/274 (45.62%), Query Frame = 2
Query: 374 FLCSLVMADTMVCVSLIA---AEMKKTPGPCFH----LLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCF----IQWDCNIYRSGF-CTIVILVLSALIMIWCYCNIFRKI-LEFNRDFIKLQASQVIRQKRGVRGLTTTL-IILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLI-MNSFINPILYAFRLREIRASYRRLF 1150
FL SL +AD VCV +A A M P + +L+ S+ SI SL +A+D YVA+F P RY +M R L + + W+++ ++G P++ W+ +P + YC+ + + +Y + F C + L+ IM Y IF ++ + R + + Q+R ++ LT + S+FL F F +I L + IS + S ++ +L NS +NP LYA+R++ SYRR F
Sbjct: 52 FLVSLAVAD--VCVGAVAIPCAIMTDLGLPRHNFLLCVLMLSVLIMLTQSSIFSLLAVAVDRYVAIFNPFRYKVIMTHRNALITIVLTWLMAFLIG----LVPAMG---WHKG-----SP-SDSYCYFVAVVDMNYMVYFNFFGCVLTPLI----IMFVIYARIFLQVRHQLRRIANEARGGAGNAQERSMQSLTKEVKTATSLFLVLF---LFTVCWIPLHVLNCISLLCPGSNTPYGLLLAAIILSHANSVVNPFLYAYRMK----SYRRAF 299
BLAST of Melanocortin 4 receptor vs. Ensembl Sea Lamprey
Match: lpar1 (lysophosphatidic acid receptor 1 [Source:ZFIN;Acc:ZDB-GENE-030616-499]) HSP 1 Score: 57.7658 bits (138), Expect = 1.705e-9 Identity = 60/235 (25.53%), Postives = 107/235 (45.53%), Query Frame = 2
Query: 464 LLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVT----NPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLI--MNSFINPILYAFRLREIRASYRRLF 1150
+L L T+ S+ +L +AI+ ++ VF ++ M+ R ++ +++I+W++S I G+ PS+ WN SI T P+ I W S T LIM+ Y +IF + + + R++ + L T I+L F+ C++P + S + N+ Y FLLI +NS +NPI+Y+FR +E+ A+++R+
Sbjct: 103 MLRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSERRVVVVIAIIWLVSIITGA----IPSMG---WNCICSIGTCSTMAPLYSSSYVIFWA----GSNLSTF-------LIMVGLYGHIFVHVWRNTIPVSRNSSKSTQRREATMSLLITVTIMLGAFIVCWTPGLVILLLDSFCSDCNVLAFEKY-----------FLLIAELNSAMNPIIYSFRDKEMVATFKRIL 307
BLAST of Melanocortin 4 receptor vs. Ensembl Sea Lamprey
Match: adrb2a (adrenoceptor beta 2, surface a [Source:ZFIN;Acc:ZDB-GENE-100414-3]) HSP 1 Score: 55.4546 bits (132), Expect = 3.448e-9 Identity = 61/220 (27.73%), Postives = 98/220 (44.55%), Query Frame = 2
Query: 500 GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIF---RKILEF-------------NRDFIKLQASQVIR--QKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILY 1105
SI +L +A+D Y+AV PLRY LMN+R FI+ VW++S ++ F P I W + + N A+ C +++ ++ + + V L +MI Y +F RK +E + IK A ++ R ++ R L T +I+ F C+ P+F + NI Q+ T F +L +NS NPI+Y
Sbjct: 7 ASIDTLCVIAVDRYIAVARPLRYETLMNKRRARFIIVAVWLVSALIS----FLP-IEMGWWKSEAAAAANNTAEDVC--EFNISLEYAVASSSVSFYLPLTVMIILYSKVFREARKQMEKINTSEGRFYNNANDSATIKNPARKLSRFLSRKEHRALKTLGLIMGTFTLCWLPFF----------VVNIVQVVWNCVPTGVFVSLNWLGYINSAFNPIIY 209
BLAST of Melanocortin 4 receptor vs. Ensembl Nematostella
Match: EDO35245 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM13]) HSP 1 Score: 65.0846 bits (157), Expect = 1.293e-11 Identity = 79/331 (23.87%), Postives = 137/331 (41.39%), Query Frame = 2
Query: 236 NNISYENSD-----RNVG---ILIFFIGSLALTSQLLTVLVIA---FSWKKLLPNIKFLCSLVMADTMVC---VSLIAAEMKKTPG----PCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCT----IVILVLSALIMIWCYCNIFR----KILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIF--NISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRR 1144
+N++ NS R++G I + + LTS L LV A F ++ P F+ SL +AD +V V A + G C L V + N S+++L ++ D Y+A+ PLRY M +++ W+ S +S PS+ W + + C I+W + S + + IMI+CYC IF+ + + ++ + Q S + R L T LI++ F + PY F SL+ +F + ++ N + + ++N INP++Y+ R + R R+
Sbjct: 2 DNLTLANSTEITPTRSIGERVIQAIVLSIICLTSVLGNALVAATIHFDYRLHKPTFYFIASLSVADIIVGAVYVPFFAVAVLDGWGFGTIWCDVLAV--TVSLSFNASLVTLALVSWDRYLAITKPLRYQAFMTSERAAALIAGAWVHSLFWAAS----PSVG---WGE----IAFDLDTNICRIEWSSKVESSKVYSLFLAFFAFFIPTAIMIYCYCKIFKVARHHVKQIKQNSVSSQQSVTVND---TRALKTILIVIGAFAVAWLPYTMF----SLTKLFAPGVVKVEATGSNAVL-----TVTLLNGCINPVIYSLRDKRFRNGIRK 307
BLAST of Melanocortin 4 receptor vs. Ensembl Nematostella
Match: EDO39915 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8R2]) HSP 1 Score: 63.5438 bits (153), Expect = 4.277e-11 Identity = 62/222 (27.93%), Postives = 101/222 (45.50%), Query Frame = 2
Query: 491 AHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCF-IQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQA--SQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
A S ++LT +A++ + A+ P R + I ++V VWI LG S Y +I F + CF +I R T+++ +L A+I+ +CY I R + + + Q S +I +++ + L T + VF C P FEIY+S+ T + +Q R I + FLL N+ +NP++YAF R S+ RL
Sbjct: 124 AMTVSAITLTVIAVERFKALVLPFREKLKLTEARIPYVVIFVWIFG--LGFSLSSYINIEF------------DSKRELCFDFSGKFHIIR----TVMVSILPAVIIAFCYLGIVRGLYWTRTIYTERQGIQSDIISKRKLCKLLVTVTV---VFFLCHLPRALFEIYLSVITKYTDAQ---KKRLDIAVEIGDFLLFTNAALNPLIYAFNSSNYRRSFSRL 321
BLAST of Melanocortin 4 receptor vs. Ensembl Nematostella
Match: EDO37207 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGH3]) HSP 1 Score: 59.6918 bits (143), Expect = 5.495e-10 Identity = 62/240 (25.83%), Postives = 100/240 (41.67%), Query Frame = 2
Query: 500 GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDF--------IKLQASQVI------------RQKR------GVRGLTTTLIILSVFLSCFSPYFFFEIYISLS-TIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASY 1138
S++SL ++ID Y A+ PL+Y LM R +V+ VW+ S + G F P +C + +TN + C +W +I + F L+M + Y +I R L+ + I R++R + T LI++ FL C+SP+F I ++ +F Q ++ FF + +L +MNS NPILY R R S+
Sbjct: 73 ASMLSLAAVSIDRYFAIITPLKYPMLMTPRMAFMLVAWVWLQSLLCG----FLPIFGWC----RYTYITN---ESICTAEWGSSIPYTMFIFGACFFAPLLVMFYSYYHILLAARRHARQMALKVGDIATPLKTAVAITLPSADNNAKRKREEREAKFKSDTKAAKTLLIVMGTFLFCWSPHF-----IGMTCLLFPSCQWPDW-----FFATTTWLAMMNSGCNPILYGVLNRRFRRSF 291
BLAST of Melanocortin 4 receptor vs. Ensembl Nematostella
Match: EDO49367 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG65]) HSP 1 Score: 59.6918 bits (143), Expect = 6.150e-10 Identity = 70/276 (25.36%), Postives = 118/276 (42.75%), Query Frame = 2
Query: 374 FLCSLVMADTMVCVSLIAAEMKKTPG-------PCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCT---IVILVLSALIMIWCYCNIFRKIL-EFNRDFIKLQASQVIRQKRGVRGL------TTTL-IILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
F+ SL +AD + + + + +T G CF L +++ SI +L +++D Y+ + P +Y M + L V VWI S IL S +SI+ P A+G + C F T IV +L LI++ Y ++ + L +F + I A+Q +KR R + T TL ++L F C+ P+F + S + R +F+ L +NS NP +YA+ E R ++R++
Sbjct: 34 FIASLAVADLLYGLIGLPFRIVQTSGTRVFTLNECF-LWIWA-DMVCAAASIANLAVISVDRYLKITKPFQYHIRMTHKRALLAVVAVWIYSAILAS----------------LSIMPWPGAKGVHLFEQSCTNLNQVFYTVANIVAFILPLLILVLNYVMVYVEALKQFRKMKILTVATQCKEEKRKQRSVIRDFKATKTLAVVLGTFTICWCPFFILFTVTQYRPLVLFSLPPGW-REFVFYMTYCVLPNLNSACNPFIYAYFNSEFRRAFRKI 290
BLAST of Melanocortin 4 receptor vs. Ensembl Nematostella
Match: EDO29093 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T4L9]) HSP 1 Score: 59.6918 bits (143), Expect = 1.442e-9 Identity = 60/223 (26.91%), Postives = 99/223 (44.39%), Query Frame = 2
Query: 503 SIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGS----SGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLI-ILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSR--NTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
S+ LT +A++ Y A+ PL + + R + +V ++W +S +L F P +N C + T Y NI + LI+ CY +I + +L N I + + I+ + + L L + V+ CF+P+ F IY++ N SQ N S N +F ++ L+ NS +NP+LYAF+ +SYRR F
Sbjct: 523 SVAFLTVVAVERYHAMVKPLSHRFRLGREQVWKVVMVIWFVSILLNIPIFIDVKFDPQLNVC--RSAFDFTTGKETATYLAFYLGINI-----------CIPGLIITACYLSILKGLLITNS--ICSETVETIQGREEKKKLAKLLASVTGVYFICFAPFVIFMIYLTAEKFLN-SQDKNSSPLLNYTYFVLTS-LIFSNSCLNPVLYAFQ----SSSYRRGF 724
BLAST of Melanocortin 4 receptor vs. Ensembl Medaka
Match: adora2b (adenosine A2b receptor [Source:NCBI gene;Acc:101172755]) HSP 1 Score: 67.781 bits (164), Expect = 6.284e-12 Identity = 82/292 (28.08%), Postives = 138/292 (47.26%), Query Frame = 2
Query: 374 FLCSLVMADTMV-CVSL-----IAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWN------NNISIVTNPM------AQGY--------CFIQWDCNI-YRSGFCTIVILVLSALIMIWCYCNIF----RKILEFNRDFIKLQAS--QVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
FL SL +AD +V C+++ I+ + C L + L T SI SL +AID Y+AV PLRY LM +T IV+I+WI+S ++G I F WN NN S+ N +G+ C+ + ++ Y F V ++L LIM+ Y IF +++ + + S Q + QK +R + II+ +F C+ P ++ T+F + ++ ++ +V+ L NS +NPI+YA+R++E R ++R++
Sbjct: 49 FLVSLAVADILVGCLAMPFAITISMGLYVDFYGCLFLACFVLVLT--QSSIFSLLAIAIDRYLAVKIPLRYKELMTGKTAREIVAILWILSFVIG-------LIPFFGWNLKNKSCNNSSVKDNTTNSEETKDRGHLLQSCKVKCYFETVVDMEYMVYFNFFVCVLLPLLIMLGIYVKIFIVARKQLRQIELKCVGNGGSQNQGLLQKE-IRAAKSLSIIVGLFAICWLPVHI----LNCLTLF----YKDLNKPSVVMYVAIILSHANSAVNPIIYAYRIQEFRNTFRKIL 322
BLAST of Melanocortin 4 receptor vs. Ensembl Medaka
Match: ENSORLT00000043029.1 (pep primary_assembly:ASM223467v1:24:10821650:10823686:1 gene:ENSORLG00000028309.1 transcript:ENSORLT00000043029.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 67.0106 bits (162), Expect = 6.786e-12 Identity = 79/305 (25.90%), Postives = 137/305 (44.92%), Query Frame = 2
Query: 275 ILIFFIGSLALTS---QLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPC--FHLLVYSLRQ----TAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTL-IILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQ 1159
IL FF+ L++ + LL ++ IA+ + P + SL +AD +V + + M + C + L+ +R T SIM+L C+++D Y AV PL Y +N+ ++F++ + W IS ++G G+ +N N +G CFI + + V +IM+ Y IF R I++ A + R T TL +L VFL C++P+F ++ F S I T+ +L + NS +NP +YAF + R++++ + +Q
Sbjct: 39 ILYFFLALLSVITVCGNLLVIISIAYFKQLHTPTHSLILSLAVADLLVGIVVFPLSMAFSLSSCLFYEGLLCKVRDSFDITLSTCSIMNLCCISVDRYFAVCQPLMYKTKINQHVVVFMIVVSWGISALIG-IGVIIAGLN------------NDKCKGSCFIDI---LMANTIGPTVSFYFPVIIMLCIYLKIFLVAQRQARS-IQMAAKCAAAVSKMERKSTKTLATVLGVFLCCWTPFFLCITFLP----FTSSPIPVPVIETL-----NWLALSNSMLNPFIYAFFYQWFRSAFKIILIYQ 317
BLAST of Melanocortin 4 receptor vs. Ensembl Medaka
Match: adrb2a (beta-2 adrenergic receptor [Source:NCBI gene;Acc:101170279]) HSP 1 Score: 65.855 bits (159), Expect = 2.907e-11 Identity = 61/232 (26.29%), Postives = 105/232 (45.26%), Query Frame = 2
Query: 500 GSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIF----RKILEFNRDFIKLQA-SQVIRQKRGV----------RGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
SI +L +AID YVA+ P RY L+ + +V +W+I+ + YP I+ VW +N S + + C Q+ NI +I+ + +IM++ Y +F R++ + N+ + S + RG + L T II+ F C+ P+F L+ I +I ++NYS F + ++ NS NP++Y R E R +++ L
Sbjct: 125 ASIGTLCVIAIDRYVAITAPFRYQSLLTKCRARIVVIFIWVIAALTS-----YPPIHMNVWRSNTSEAEKCLNKTDC-CQFHTNIQYGITSSIISFYIPLIIMVFVYSRVFLAAKRQLKKINQSVGRFHVDSSEDKNGRGQKKAKFYLREHKALKTLGIIMGTFTLCWLPFFI------LNVIASIWNVNNYS----VFMILNWIGYSNSMFNPVIYC-RSPEFRYAFKELL 339
BLAST of Melanocortin 4 receptor vs. Ensembl Medaka
Match: ENSORLT00000038808.1 (pep primary_assembly:ASM223467v1:24:10807507:10809687:1 gene:ENSORLG00000026588.1 transcript:ENSORLT00000038808.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 65.0846 bits (157), Expect = 3.380e-11 Identity = 78/305 (25.57%), Postives = 136/305 (44.59%), Query Frame = 2
Query: 275 ILIFFIGSLALTS---QLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLIAAEMKKTPGPC--FHLLVYSLRQ----TAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTL-IILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQ 1159
IL FF+ L++ + LL ++ IA+ + P + SL +AD +V + + M + C + L+ +R T SIM+L C+++D Y AV PL Y +N+ ++F++ + W IS ++G G+ +N + +G CFI + + V +IM+ Y IF R I++ A + R T TL +L VFL C++P+F ++ F S I T+ +L + NS +NP +YAF + R++++ + Q
Sbjct: 38 ILYFFLALLSVITICGNLLVIISIAYFKQLHTPTHSLILSLAVADLLVGIVVFPLSMAFSLSSCLFYEGLLCKVRDSFDITLSTCSIMNLCCISVDRYFAVCQPLMYKTKINQHVVVFMIVVSWGISALIG-IGVIIAGLN------------DDKCEGSCFIDI---LMANTIGPTVSFYFPVIIMLCIYLKIFLVAQRQARS-IQMAAKCAAAVSKMERKSTKTLATVLGVFLCCWTPFFLCITFLP----FTSSPIPVPVIETL-----NWLTLSNSMLNPFIYAFFYQWFRSAFKIIVSGQ 316
BLAST of Melanocortin 4 receptor vs. Ensembl Medaka
Match: gpr186 (G protein-coupled receptor 186 [Source:ZFIN;Acc:ZDB-GENE-060503-489]) HSP 1 Score: 65.0846 bits (157), Expect = 3.487e-11 Identity = 62/263 (23.57%), Postives = 118/263 (44.87%), Query Frame = 2
Query: 362 PNIKFLCSLVMADTMVCVSLIAAEMKK---TPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINF-CVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRK---ILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIR 1129
P L SL +AD + V+LI + + P LL L T+ S+ SL +A+D Y+++ L Y +RR ++ +VW+ +C +G+ P++ + C+ + + V P+ + Y ++ GF +V + L I C + R+ + R F+ R G RG + +++LSVF+ C+ P+ + + + + S ++ + + +S +NPILY+ R ++IR
Sbjct: 70 PVFLLLASLGLADLLAGVALILHFLFQFCVEPRDWSQLLTSGLLVTSLTASLCSLMGVALDRYLSLSHALTYGSGQSRRRAATLLLLVWLGACAIGAG----PAMGWHCLEDLDSCSVAPPLTRTY------LSLLCGGFLVVVAVTLQLYAGI---CRVARRHAHAIATQRHFLPTNQPYANRHSTG-RGFSRLILVLSVFVGCWMPFSLWGL------------LGDASSPPLYTYATLVPAAGSSLLNPILYSLRNKDIR 306
BLAST of Melanocortin 4 receptor vs. Planmine SMEST
Match: SMESG000016279.1 (SMESG000016279.1) HSP 1 Score: 630.172 bits (1624), Expect = 0.000e+0 Identity = 337/338 (99.70%), Postives = 337/338 (99.70%), Query Frame = 2
Query: 392 MADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQXXXXXXXXXXXXXXVTKRNFSLRLKRYKIKEREDSCSRRHSDPENIPLQESCPVSKMTDVQSPXXXXXXXXXXXXCRTKIGS 1405
MADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQSSIRSRISHASISAVTKRNFSLRLKRYKIKEREDSCSRRHSDPENIPLQESCPVSKMTDVQSPVKVNNN NLVVICRTKIGS
Sbjct: 1 MADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQASQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQSSIRSRISHASISAVTKRNFSLRLKRYKIKEREDSCSRRHSDPENIPLQESCPVSKMTDVQSPVKVNNNKNLVVICRTKIGS 338
BLAST of Melanocortin 4 receptor vs. Planmine SMEST
Match: SMESG000055536.1 (SMESG000055536.1) HSP 1 Score: 90.5077 bits (223), Expect = 4.255e-19 Identity = 100/340 (29.41%), Postives = 169/340 (49.71%), Query Frame = 2
Query: 284 FFIGSLALTSQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCVSLI----------------------AAEMKKTP---GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKL------------QASQ-------VIRQ-------KRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLF 1150
F IG L++ +L V+ I L NI+ +C LV D +V V +I + E+ TP PC L+++ LR +NG+++SLT LA+DLYVA+ +PL Y LM + + FI+ +++I+ L S L+ P + N + + N YCF +W +I +S + T I++++ +++ Y +F +I F+++ ++ A+Q V+R K+ RGLTTTL++L FL CF P F E+Y+ +S S Y + + L ++ S ++P+LY++RL++I+ SY RLF
Sbjct: 30 FTIGILSVFLNILAVIAICRIRGSLPVNIRLVCCLVAFDLLVSVVVIFETSISVIFYSATHKAVNDTIESNEIHLTPLKYHPCMALILHILRYAGYNGTLLSLTALAVDLYVAIMYPLNYSSLMRKDRVNFIIVFIFVIALTLASCILYVP----LLIRNEMPLARN---FSYCFQRWQSHI-KSCYATFGIVLIAIVVVSVVYITVFYQIRNFHKNGVRCAQYTNKQVPLNNNANQGNKTRNNVLRGSSNTSNLKKNQRGLTTTLVLLLAFLCCFLPSFIIEMYLMISANHLTSM---YQYDIKLTQIMLNLPLICSALDPLLYSYRLKDIQISYLRLF 358
BLAST of Melanocortin 4 receptor vs. Planmine SMEST
Match: SMESG000018665.1 (SMESG000018665.1) HSP 1 Score: 73.9442 bits (180), Expect = 6.754e-15 Identity = 50/174 (28.74%), Postives = 90/174 (51.72%), Query Frame = 2
Query: 671 FCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQA------------SQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLL---IMNSFINPILYAFRLREIRASYRRL 1147
F + +N +++ +CF+ W+ +I +S T +ILV+ I+ Y I F F Q S+ I+ KR RGL T +++LS FL CF P EIY+++S+ F+ + Y R + ++ L+ I++S +NP+LY +RL+E+++ +R++
Sbjct: 12 FPISKSNREHFPGSVSKSFCFLTWNNHI-KSNLITFIILVIGLFIVSIVYVIAIYNIHGFRNQFSTTQTNRSKNLPWTSRISKAIKFKRHYRGLFTIILLLSSFLCCFLPSIILEIYLTISSTFH--KFEEYHRKIV--SITRLLMTLPILSSVLNPLLYCYRLKEVKSGFRKI 180
BLAST of Melanocortin 4 receptor vs. Planmine SMEST
Match: SMESG000023113.1 (SMESG000023113.1) HSP 1 Score: 56.9954 bits (136), Expect = 1.312e-8 Identity = 75/287 (26.13%), Postives = 120/287 (41.81%), Query Frame = 2
Query: 311 SQLLTVLVIAFSWKKLLPNIKFLCSLVMADTMVCV-----SLIAAEMKKTP-GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFIKLQA--SQVIRQKRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRL 1147
+ L+ V VI F + +FLCSL ++D V V S+I ++ P G F S SI+ L +AID Y+++ LRY LM R L I+ +W++S ++ ++ WN G C D N + ++ + L + Y I+R I F I+ Q S+ + K + + T +I+ +F C+ P+F + + + N I F ++ +NS NPILY F RE R S+ RL
Sbjct: 35 NTLVVVSVIKFRRLRSQMCFRFLCSLAISDICVAVFVMFVSMIYFLVQLWPFGWVFCYFWMSCDVMCCTASILHLCAVAIDRYISIAHGLRYATLMTGRRALTIIVAIWLLSVLISFVPIYSNWFGPLNWNGTF--------HGSC--DLDVNHVYALISSLTSFYIPFLALSVIYFEIYR-IASFQAKQIRHQQSRSESKKSKNDRKAIKTVGLIVGLFSLCWFPFFIMYV------VRGFCKTCFIDNNWILFIT--WIGYVNSSFNPILYCFTQREFRNSFIRL 302
BLAST of Melanocortin 4 receptor vs. Planmine SMEST
Match: SMESG000011585.1 (SMESG000011585.1) HSP 1 Score: 51.2174 bits (121), Expect = 9.615e-7 Identity = 69/340 (20.29%), Postives = 142/340 (41.76%), Query Frame = 2
Query: 269 VGILIFFIGSLALTSQLLTVLVIAFSWKKLLPNIK------FLCSLVMADTMVCVSLIAAEMKKTP-------GPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYVAVFFPLRYCCLMNRRTILFIVSIVWIISCILGSSGLFYPSINFCVWNNNISIVTNPMAQGYCFIQWDCNIYRSGFCTIVILVLSALIMIWCYCNIFRKILEFNRDFI-----------------KLQASQVIRQ-------------KRGVRGLTTTLIILSVFLSCFSPYFFFEIYISLSTIFNISQISNYSRNTIFFHVSGFLLIMNSFINPILYAFRLREIRASYRRLFEFQ 1159
+GI++ F S LVI WK P ++ F+ SL AD +V + ++ + +T GP + S S++ + C+ +D Y+A+ P +Y ++ + I+++ WI S ++ + I+ ++ ++V + C + N+ + + + + + IM Y IF++ + I +Q+ I++ KR + T II+ F++C+ P+F + T+ N+ Q S+ S I + ++ +NS +NPI+YAF RE R +++++ ++
Sbjct: 30 MGIIVIFAASFG------NGLVIISVWK--YPRLRRQITNHFVFSLAFADFLVAILVMPFNLIQTVNNGRWLFGPVLCNIFNSNDVFFSTASLIHIGCIGLDRYIAIIKPFKYEIILTNSRVAIILTVSWITSLLIS-----HIPIHSGIYTTEENLVLLKFCRLVC--HFKVNMIYAIVSSTISFWIPSSIMCVVYLKIFKEAKNQEKKIILATPYPKENRNSLTLDMNIQSQNFIKKSQSVSSNMSKRNFKREHKAAKTLGIIMGCFIACWLPFFIWY------TVSNVCQ-SSCSFPEIIGDIVFWIGYVNSTLNPIIYAFYNREFRKAFKQVLKYN 347 The following BLAST results are available for this feature:
BLAST of Melanocortin 4 receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Melanocortin 4 receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Melanocortin 4 receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Melanocortin 4 receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30026936 ID=SMED30026936|Name=Melanocortin 4 receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=1421bpback to top protein sequence of SMED30026936-orf-1 >SMED30026936-orf-1 ID=SMED30026936-orf-1|Name=SMED30026936-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=339bp MADTMVCVSLIAAEMKKTPGPCFHLLVYSLRQTAHNGSIMSLTCLAIDLYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
