noggin-like protein 8

Overview


Name	noggin-like protein 8 (ACO06233.1)
Smed ID	SMED30026932
Length (bp)	1189

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of noggin-like protein 8 (SMED30026932) t-SNE clustered cells

Violin plots show distribution of expression levels for noggin-like protein 8 (SMED30026932) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of noggin-like protein 8 (SMED30026932) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for noggin-like protein 8 (SMED30026932) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30026932

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 18

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
ventral region of the whole animal	SMED30026932	SMESG000008387.1	FJ471490.1	smed_ncbi_20200123	PMID:23318641 Chen et al., 2013
epidermis	SMED30026932	SMESG000008387.1	dd_Smed_v4_8738_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30026932	SMESG000008387.1	dd_Smed_v4_8738_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30026932	SMESG000008387.1	dd_Smed_v4_8738_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30026932	SMESG000008387.1	dd_Smed_v4_8738_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30026932	SMESG000008387.1	Contig47009	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30026932	SMESG000008387.1	Contig47009	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
head region	SMED30026932	SMESG000008387.1	dd_Smed_v6_8738_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
enteric muscle cell	SMED30026932	SMESG000008387.1	dd_Smed_v4_8738_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018
pharynx	SMED30026932	SMESG000008387.1	FJ471490.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
cephalic ganglia	SMED30026932	SMESG000008387.1	FJ471490.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
mouth	SMED30026932	SMESG000008387.1	FJ471490.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
dorsal region of the whole animal	SMED30026932	SMESG000008387.1	FJ471490.1	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
pharynx	SMED30026932	SMESG000008387.1	FJ471490	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
cephalic ganglia	SMED30026932	SMESG000008387.1	FJ471490	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
mouth	SMED30026932	SMESG000008387.1	FJ471490	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
dorsal region of the whole animal	SMED30026932	SMESG000008387.1	FJ471490	smed_ncbi_20200123	PMID:19174194 Molina et al., 2009
muscle cell	SMED30026932	SMESG000008387.1	dd_Smed_v4_8738_0_1	dd_Smed_v4	PMID:30962434 Cote et al., 2019

Note: Hover over icons to view figure legend

Homology

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BLAST of noggin-like protein 8 vs. Ensembl Human
Match: NOG (noggin [Source:HGNC Symbol;Acc:HGNC:7866])

HSP 1 Score: 60.8474 bits (146), Expect = 4.673e-10
Identity = 32/96 (33.33%), Postives = 52/96 (54.17%), Query Frame = 2

Query:  521 SVAADALNLTFHDG--TGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            ++ ++   L F +G   G +  L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+ S S  L +L W C+
Sbjct:  115 AMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSK--RSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 8 vs. Ensembl Zebrafish
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 60.4622 bits (145), Expect = 3.640e-10
Identity = 40/125 (32.00%), Postives = 63/125 (50.40%), Query Frame = 2

Query:  437 DTAWTSIDPPKTLKERGDNYRDMVESKLSVAA----DALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            D+ + S+ PP+  +  G+   D  E +L++A     D  NL F    G +    + + R  + WL   + C + Y W DLG  FWP+++R G C     +SCS P GM C+ + S  + +L W C
Sbjct:   67 DSRFLSVGPPQD-RYAGNEDLDEQELQLNLAGMMPKDIKNLDFDAPWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTK--RSCSVPEGMVCKPAKSTHITLLRWRC 188

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BLAST of noggin-like protein 8 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 56.9954 bits (136), Expect = 5.974e-9
Identity = 37/125 (29.60%), Postives = 63/125 (50.40%), Query Frame = 2

Query:  446 WTSIDPPKTLKERGDNYRDMVESKLS-------VAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            + SI+PP+  K  G +  ++ ES+L        +  +   + F    G ++   + + R  + WL     C + + W+DLG  FWP++++ G C N   +SCS P GM C+ + S  L +L W C
Sbjct:   76 FMSINPPED-KHAGQD--ELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNK--RSCSVPEGMVCKPAKSSHLTVLRWRC 195

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Query:  446 WTSIDPPKTLKERGDNYRDMVESKLS-------VAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            + SI+PP+  K  G +  ++ ES+L        +  +   + F    G ++   + + R  + WL     C + + W+DLG  FWP++++ G C N   +SCS P GM C+ + S  L +L W C
Sbjct:   76 FMSINPPED-KHAGQD--ELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNK--RSCSVPEGMVCKPAKSSHLTVLRWRC 195

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Query:  446 WTSIDPPKTLKERGDNYRDMVESKLS-------VAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            + SI+PP+  K  G +  ++ ES+L        +  +   + F    G ++   + + R  + WL     C + + W+DLG  FWP++++ G C N   +SCS P GM C+ + S  L +L W C
Sbjct:   76 FMSINPPED-KHAGQD--ELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKPSKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNK--RSCSVPEGMVCKPAKSSHLTVLRWRC 195

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BLAST of noggin-like protein 8 vs. Ensembl Zebrafish
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 55.0694 bits (131), Expect = 2.229e-8
Identity = 26/68 (38.24%), Postives = 37/68 (54.41%), Query Frame = 2

Query:  599 RMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            R F  WL     C + Y W+DLG  FWP++I+ G C +   +SCS+P GM C+   +     L W C+
Sbjct:  122 RKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFSE--RSCSFPEGMSCKPVKAVTKTFLRWYCQ 187

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BLAST of noggin-like protein 8 vs. Ensembl Xenopus
Match: nog4 (noggin 4 [Source:NCBI gene;Acc:733455])

HSP 1 Score: 71.633 bits (174), Expect = 1.286e-13
Identity = 29/70 (41.43%), Postives = 42/70 (60.00%), Query Frame = 2

Query:  590 HVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            HV    R WL+++A+C +   W DLG +FWP+W+R   C +    +CSWPPGM CR +    + +L W C
Sbjct:  146 HVQNEIRQWLVQRASCQLTSTWVDLGTVFWPRWVRHTDC-DGANTACSWPPGMACRQAQLTQIKLLAWHC 214

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BLAST of noggin-like protein 8 vs. Ensembl Xenopus
Match: nog (noggin [Source:NCBI gene;Acc:493191])

HSP 1 Score: 67.781 bits (164), Expect = 1.475e-12
Identity = 35/99 (35.35%), Postives = 56/99 (56.57%), Query Frame = 2

Query:  521 SVAADALNLTFHDG-TGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVN 814
            ++ A+   L F++G  G ++ L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+A+ S  L IL W C+  V 
Sbjct:  106 AMPAEIKGLEFYEGLQGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSK--RSCSVPEGMVCKAAKSMHLTILRWRCQRRVQ 202

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BLAST of noggin-like protein 8 vs. Ensembl Xenopus
Match: acad10 (acyl-CoA dehydrogenase family member 10 [Source:Xenbase;Acc:XB-GENE-967980])

HSP 1 Score: 56.225 bits (134), Expect = 1.587e-8
Identity = 27/68 (39.71%), Postives = 37/68 (54.41%), Query Frame = 2

Query:  599 RMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            R F  WL     C + Y W+DLG  FWP++I+ G C +   +SCS+P GM C+   S     L W C+
Sbjct:  128 RKFLQWLWAYTYCPVMYTWKDLGVRFWPRFIKEGHCFSE--KSCSFPEGMYCKPIKSVTKTFLRWYCQ 193

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BLAST of noggin-like protein 8 vs. Ensembl Mouse
Match: Nog (noggin [Source:MGI Symbol;Acc:MGI:104327])

HSP 1 Score: 60.8474 bits (146), Expect = 3.148e-10
Identity = 32/96 (33.33%), Postives = 52/96 (54.17%), Query Frame = 2

Query:  521 SVAADALNLTFHDG--TGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            ++ ++   L F +G   G +  L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+ S S  L +L W C+
Sbjct:  115 AMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSK--RSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 8 vs. UniProt/SwissProt
Match: sp|P49011|NOGG_XENLA (Noggin OS=Xenopus laevis OX=8355 GN=nog PE=1 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 5.178e-11
Identity = 34/99 (34.34%), Postives = 56/99 (56.57%), Query Frame = 2

Query:  521 SVAADALNLTFHDGTGTQ-YVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVN 814
            ++ A+   L F++G  ++ + L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+A+ S  L IL W C+  V 
Sbjct:  106 AMPAEIKGLEFYEGLQSKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSK--RSCSVPEGMVCKAAKSMHLTILRWRCQRRVQ 202

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BLAST of noggin-like protein 8 vs. UniProt/SwissProt
Match: sp|O93525|NOGG_CHICK (Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1)

HSP 1 Score: 63.929 bits (154), Expect = 1.923e-10
Identity = 33/96 (34.38%), Postives = 53/96 (55.21%), Query Frame = 2

Query:  521 SVAADALNLTFHDG--TGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            ++  +   L F+DG   G ++ L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+ + S  L IL W C+
Sbjct:  106 AMPGEIKGLEFYDGLQPGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGSRFWPRYVKVGSCYSK--RSCSVPEGMVCKPAKSVHLTILRWRCQ 199

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BLAST of noggin-like protein 8 vs. UniProt/SwissProt
Match: sp|Q9W741|NOGG1_DANRE (Noggin-1 OS=Danio rerio OX=7955 GN=nog1 PE=2 SV=1)

HSP 1 Score: 60.8474 bits (146), Expect = 2.191e-9
Identity = 40/125 (32.00%), Postives = 63/125 (50.40%), Query Frame = 2

Query:  437 DTAWTSIDPPKTLKERGDNYRDMVESKLSVAA----DALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            D+ + S+ PP+  +  G+   D  E +L++A     D  NL F    G +    + + R  + WL   + C + Y W DLG  FWP+++R G C     +SCS P GM C+ + S  + +L W C
Sbjct:   67 DSRFLSVGPPQD-RYAGNEDLDEQELQLNLAGMMPKDIKNLDFDAPWGKKRKASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTK--RSCSVPEGMVCKPAKSTHITLLRWRC 188

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BLAST of noggin-like protein 8 vs. UniProt/SwissProt
Match: sp|P97466|NOGG_MOUSE (Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1)

HSP 1 Score: 60.8474 bits (146), Expect = 2.202e-9
Identity = 32/96 (33.33%), Postives = 52/96 (54.17%), Query Frame = 2

Query:  521 SVAADALNLTFHDG--TGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            ++ ++   L F +G   G +  L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+ S S  L +L W C+
Sbjct:  115 AMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSK--RSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 8 vs. UniProt/SwissProt
Match: sp|Q13253|NOGG_HUMAN (Noggin OS=Homo sapiens OX=9606 GN=NOG PE=1 SV=1)

HSP 1 Score: 60.8474 bits (146), Expect = 2.244e-9
Identity = 32/96 (33.33%), Postives = 52/96 (54.17%), Query Frame = 2

Query:  521 SVAADALNLTFHDG--TGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            ++ ++   L F +G   G +  L + + R  + WL  +  C + Y W DLG  FWP++++ G C +   +SCS P GM C+ S S  L +L W C+
Sbjct:  115 AMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSK--RSCSVPEGMVCKPSKSVHLTVLRWRCQ 208

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BLAST of noggin-like protein 8 vs. TrEMBL
Match: C1JAC8 (Noggin-like protein 8 OS=Schmidtea mediterranea OX=79327 GN=nlg8 PE=2 SV=1)

HSP 1 Score: 580.096 bits (1494), Expect = 0.000e+0
Identity = 311/311 (100.00%), Postives = 311/311 (100.00%), Query Frame = 2

Query:  119 MMNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESXXXXXXXXXXXXXXXXYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 1051
            MMNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKRLLHEKRDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESRERNKRRWTKTRRRRRYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA
Sbjct:    1 MMNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKRLLHEKRDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESRERNKRRWTKTRRRRRYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 311

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BLAST of noggin-like protein 8 vs. TrEMBL
Match: A0A5K3F9N3 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 201.06 bits (510), Expect = 7.472e-58
Identity = 111/284 (39.08%), Postives = 169/284 (59.51%), Query Frame = 2

Query:  326 NMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERGDNY----------RDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEE--------------------DVNLREFN-----RRKQRESXXXXXXXXXXXXXXXXYPNEKTFNN-------QENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 1051
            +MR++G+ I+  ++++L P +S + + RL +LL  K D  WTS +PP+ L++RG +            + V+S L   A+ALN+TF D TG Q++LPE  +++FRNWL+++ATC MD+IW+DLG L+WP+WIR G+C+  L  SCSWPPGMKC+ SGSR L +L W CE+                     +NLR        RR+ R++   +     +  ++RR+   +           +E R ++ +RLI+  S+ +NGY C W V KYLI+DKC+CSCA
Sbjct:   36 SMRVMGQPINPNIVSHLHPDVSPRKIHRLWKLLGGKEDKYWTSEEPPRVLRQRGVSGMMSDASNPPGTNSVDSNLIRKANALNMTFRDQTGAQFLLPETQIQIFRNWLIEQATCEMDFIWKDLGSLYWPRWIRMGVCLARLGSSCSWPPGMKCQPSGSRVLRLLNWNCEDAAQASSNSPLSRQTRSLRQPTINLRYHQNSNEYRRQPRQTYLPHASPMWRYYQQRRWKGRRDVAGPLDPAQLEEQRARKARRLIEKLSVTANGYRCSWQVQKYLISDKCTCSCA 319

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BLAST of noggin-like protein 8 vs. TrEMBL
Match: A0A183LAN2 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS857 PE=4 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 1.370e-56
Identity = 125/358 (34.92%), Postives = 193/358 (53.91%), Query Frame = 2

Query:  110 SNFMMNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPST-NNDKYTKVNMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERG----------DNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEE--DVNLRE-----------------------------FNRRKQRESXXXXXXXXXXXXXXXXYPNEKTFNNQ--ENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 1051
            +N  +N+   + PVL  +LI+ ++       DM +                Y   + + DWP++  +++Y+K+NMRI+G+ ID +V+N+L P +S   +K+L+++L    D  WTS  PP+ L++RG          ++Y  + ++KL      LN TF +  G  + L +  ++ +R WL+++ATC MD+IWEDLGPLFWP+WIRRG+C+N    SCSWP GMKCR SGSRAL +L+W CE+   V  RE                                + +R++  R   +    +    Y   +   N   E R +R +RLIK  S+ +NGY+C W V KYLI+D+CSCSC+
Sbjct:   60 TNSPLNIIKHNSPVLSNSLISSID-------DMKQ----------------YKNNQPITDWPTSLASEEYSKINMRIMGQPIDPSVVNHLHPDVSQHKIKKLRKILSGNLDKEWTSETPPRVLRQRGISGSFNTNNQESYTSL-DAKLLKEIRELNFTFRNSYGVYFTLTDEQIQPYRYWLIERATCEMDFIWEDLGPLFWPRWIRRGVCLNRPGHSCSWPSGMKCRPSGSRALQLLHWKCEDAAQVQTREHAADQRIRRRVSMNTFHSGFYEMEPVTDIIKSKHKRDTYARLSLKDNSLQHINSYRKLQAHTNSKDEKRRRRARRLIKRLSVTANGYHCYWQVQKYLISDRCSCSCS 393

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BLAST of noggin-like protein 8 vs. TrEMBL
Match: A0A0R3UM00 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS8737 PE=4 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 7.954e-56
Identity = 111/294 (37.76%), Postives = 169/294 (57.48%), Query Frame = 2

Query:  326 NMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERGDNY----------RDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEE--------------------DVNLREFN---------------RRKQRESXXXXXXXXXXXXXXXXYPNEKTFNN-------QENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 1051
            +MR++G+ I+  ++++L P +S + + RL +LL  K D  WTS +PP+ L++RG +            + V+S L   A+ALN+TF D TG Q++LPE  +++FRNWL+++ATC MD+IW+DLG L+WP+WIR G+C+  L  SCSWPPGMKC+ SGSR L +L W CE+                     +NLR                  RR+ R++   +     +  ++RR+   +           +E R ++ +RLI+  S+ +NGY C W V KYLI+DKC+CSCA
Sbjct:  122 SMRVMGQPINPNIVSHLHPDVSPRKIHRLWKLLGGKEDKYWTSEEPPRVLRQRGVSGMMSDASNPPGTNSVDSNLIRKANALNMTFRDQTGAQFLLPETQIQIFRNWLIEQATCEMDFIWKDLGSLYWPRWIRMGVCLARLGSSCSWPPGMKCQPSGSRVLRLLNWNCEDAAQASSNSPLSRQTRSLRQPTINLRYHQQNVDGVPGTPNSNEYRRQPRQTYLPHASPMWRYYQQRRWKGRRDVAGPLDPAQLEEQRARKARRLIEKLSVTANGYRCSWQVQKYLISDKCTCSCA 415

[Close]

BLAST of noggin-like protein 8 vs. TrEMBL
Match: A0A0R3T561 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS2198 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 3.569e-54
Identity = 107/296 (36.15%), Postives = 161/296 (54.39%), Query Frame = 2

Query:  308 DKYTKVNMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERGDNY-----------RDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLRE-------------------FNRRKQRESXXXXXXXXXXXXXXXXYPNEKTF------------------NNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 1051
            D     +MR++G+ I+  +++ L P +S + + +L RLL  K D  WTS +PP+ L++RG +             + V++ L   A ALN+TF D TG QY+L +H +++FRNWL++ ATC MD+IW+DLG L+WP+WIR G+C+  L  SCSWPPGMKC+ SGSR L +L W CE+                          N R Q +  +  ++      ++   P  + +                    +E R ++ KRLI+  S+ ++GY C W V KYLI+DKC+CSCA
Sbjct:  129 DSTQARSMRVMGQPINPNIVSQLHPDVSPRKISKLWRLLGGKDDKYWTSEEPPRVLRQRGVSGMMSDGATHPPGANPVDTNLIRKAQALNMTFRDETGAQYLLTDHQIKIFRNWLIETATCEMDFIWKDLGSLYWPRWIRMGVCLARLGSSCSWPPGMKCQPSGSRVLRLLNWNCEDAAQAETSSNSDQALTRKVRSPEPSPMNLRYQFQDNQNGRQARQMYSQQAPSPMWRYYRLGRKKGRRDASLPLDPAQQEEGRARKAKRLIEKLSVTASGYRCSWQVQKYLISDKCTCSCA 424

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Cavefish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 53.9138 bits (128), Expect = 4.311e-8
Identity = 26/67 (38.81%), Postives = 37/67 (55.22%), Query Frame = 2

Query:  599 RMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            R  + WL     C + Y W+DLG  FWP++++ G C +   +SCS P GM C  + S  L +L W C
Sbjct:  108 RRLQLWLWSYTFCPVVYAWQDLGSRFWPRYVKVGSCASK--RSCSVPEGMVCSPAKSAHLTLLRWYC 172

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Cavefish
Match: ENSAMXT00000051007.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000650.1:142689:143405:-1 gene:ENSAMXG00000039724.1 transcript:ENSAMXT00000051007.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.373 bits (124), Expect = 1.557e-7
Identity = 26/72 (36.11%), Postives = 37/72 (51.39%), Query Frame = 2

Query:  605 FRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLR 820
             R +  ++A C +   W DLG  FWP+++R G C     +SCS P GM C  + S  + +L W C     LR
Sbjct:  119 LREFERERALCPVVQTWSDLGARFWPRYVRMGSCSRE--RSCSVPAGMLCTPAASTHVTLLRWRCARRGTLR 188

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009391.1 (pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-1 gene:ENSPMAG00000008500.1 transcript:ENSPMAT00000009391.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 82.0333 bits (201), Expect = 1.495e-18
Identity = 45/129 (34.88%), Postives = 57/129 (44.19%), Query Frame = 2

Query:  437 DTAWTSIDPPKTLKERGD--------NYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            D  W S+  P +    GD        +       KL  AA ALN T    +G      E        WLL+KA C +   W DLG +FWP+W+RR  C  +    CSWP GM C  + S  + IL W C
Sbjct:   43 DPFWMSVKRPSSSSTTGDIGALATRSSAVTAAGRKLHAAARALNFTVLTDSGAAVAATEATAAFMTRWLLQKAECGVASSWHDLGSVFWPRWVRRSHCEESGGGGCSWPAGMSCAPAQSTHIKILAWHC 171

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Sea Lamprey
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 56.9954 bits (136), Expect = 8.872e-10
Identity = 27/79 (34.18%), Postives = 42/79 (53.16%), Query Frame = 2

Query:  566 GTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            G +  + +   R    WL     C + Y W+DLG  FWP++++ G C N   +SCS+P GM C+   S +  +L W C+
Sbjct:  120 GQKIKIGKRARRKILQWLWSYTFCPVLYTWKDLGERFWPRFVKEGSCYN--GRSCSFPEGMACKPFKSASKTLLRWHCQ 196

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011420.1 (pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gene:ENSPMAG00000010393.1 transcript:ENSPMAT00000011420.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 5.277e-9
Identity = 27/67 (40.30%), Postives = 38/67 (56.72%), Query Frame = 2

Query:  599 RMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            R  + +L     C + Y W+DLG  FWP+++R G C +   +SCS P GM C+A  S +  IL W C
Sbjct:  145 RKMQLFLWAYTQCPVAYAWKDLGGRFWPRYVREGSCQSG--RSCSIPAGMSCKAQRSTSKAILRWYC 209

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Sea Lamprey
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 51.2174 bits (121), Expect = 9.591e-8
Identity = 27/79 (34.18%), Postives = 39/79 (49.37%), Query Frame = 2

Query:  566 GTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            G +  L +   R F  WL     C + Y W++L   FWP++I+ G C +  A+SCS P GM C+         L W C+
Sbjct:  131 GQKLKLGKRARRKFLQWLWAHTACPVVYSWKELNVRFWPRYIKEGSCYS--ARSCSVPEGMVCKPVKFSNKTFLRWHCQ 207

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Nematostella
Match: EDO36981 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH37])

HSP 1 Score: 58.5362 bits (140), Expect = 7.458e-11
Identity = 28/76 (36.84%), Postives = 42/76 (55.26%), Query Frame = 2

Query:  581 LPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEED 808
            L   + R    WLL++  C + Y W D+GP FWP++++R  C    ++ CS  P  +C  S SR  +IL W C +D
Sbjct:    1 LSREMERFMMGWLLQRENCPVVYSWRDMGPHFWPRFVKRATCK---SKQCSIDPSTQCEPSNSRYFNILRWHCMDD 73

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Nematostella
Match: EDO36952 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH36])

HSP 1 Score: 44.669 bits (104), Expect = 4.339e-6
Identity = 23/67 (34.33%), Postives = 38/67 (56.72%), Query Frame = 2

Query:  599 RMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 799
            R  + WL + ++C +   W+D G L WP++   G C      +CS+P GMKC+ S ++ + +L W C
Sbjct:   26 RKLQLWLWELSSCPVYQKWKDQGQLIWPRYRNIGRCSRK--STCSYPGGMKCKRSKTKRVALLRWFC 90

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Medaka
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 61.6178 bits (148), Expect = 1.221e-10
Identity = 36/122 (29.51%), Postives = 58/122 (47.54%), Query Frame = 2

Query:  437 DTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACE 802
            D  + SI  P  +     +Y+  ++  +      L+LT     G +  + +   R F  WL     C + Y W+DLG  FWP++I+ G C +   +SCS+P GM C+ + S     L W C+
Sbjct:   72 DPNFMSISSPLQVNLSASDYQVKLQGPMPNEIKKLDLT-ETPYGKRVKVGKKARRKFLQWLWTYTHCPVVYTWKDLGVRFWPRYIKEGKCFSE--RSCSFPEGMSCKPAKSINKIFLRWYCQ 190

[Close]

BLAST of noggin-like protein 8 vs. Ensembl Medaka
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 58.5362 bits (140), Expect = 1.432e-9
Identity = 35/126 (27.78%), Postives = 63/126 (50.00%), Query Frame = 2

Query:  437 DTAWTSIDPPKTLKERGDNYRD---MVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEE 805
            D+ + S+ PP  +K   ++  D   +  +   +  +   + F   +G ++   + + R  + WL   + C + Y W DLG  FWP+++R G C++   +SCS P GM C+ + S  L  L W C +
Sbjct:   78 DSRFLSVSPPVEVKHAANDELDDFALQRAGGIMPKEIRAVDFDLQSGKKHKPSKKLKRRLQQWLWAYSFCPVLYSWTDLGNRFWPRFVRVGSCLSK--RSCSVPEGMVCKPASSTHLTTLRWRCVQ 201

[Close]

BLAST of noggin-like protein 8 vs. Planmine SMEST
Match: SMESG000008387.1 (SMESG000008387.1)

HSP 1 Score: 577.785 bits (1488), Expect = 0.000e+0
Identity = 310/310 (100.00%), Postives = 310/310 (100.00%), Query Frame = 2

Query:  122 MNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESXXXXXXXXXXXXXXXXYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 1051
            MNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKRLLHEKRDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESRERNKRRWTKTRRRRRYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA
Sbjct:    1 MNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKRLLHEKRDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESRERNKRRWTKTRRRRRYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSCA 310

[Close]

BLAST of noggin-like protein 8 vs. Planmine SMEST
Match: SMESG000016086.1 (SMESG000016086.1)

HSP 1 Score: 180.644 bits (457), Expect = 1.364e-53
Identity = 106/287 (36.93%), Postives = 165/287 (57.49%), Query Frame = 2

Query:  212 KANVKVSEVLKRKDPFGYGKIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXX-XXXXDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREF----NRRKQRESXXXXXXXXXXXXXXXXYPNEKTFNN---QENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSC 1048
            KA VK+S+V+  K      +  +   WP    DK  K+ ++++G NI     +N +P +  +N K+L++L      DT W SI+ P  L+      +     +L  A   LN TF D  G    +PE++  +FR WL++ ++C M+++WEDLG +FWP WIRRG+C +  ++SCSWP GM C+ SGSR LH+L W C +D N  E     N + + ++++  K+     +RRRR+P+    NN   +    K+  R+ ++ S AS+GY+C+W + KY INDKCSC C
Sbjct:   34 KAKVKLSDVMNEK------RRSRSESWPPDEQDKNFKLGIKLIGDNISANFDSNTKPNLQQRNPKKLEKLFWKYHLDTQWLSINKPDVLRGLMPVEQINARQELMKAVGNLNFTFVDSVGAMLEIPENMQNLFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTS--SKSCSWPSGMACKHSGSRTLHLLRWVCLKDTNGTEAKKLQNFKIKLKTQKMKKQMLYYQKRRRRFPDSTRSNNLSKEVQSKKKATRITRLLSRASDGYFCQWSMLKYYINDKCSCQC 312

[Close]

BLAST of noggin-like protein 8 vs. Planmine SMEST
Match: SMESG000017268.1 (SMESG000017268.1)

HSP 1 Score: 133.65 bits (335), Expect = 2.549e-36
Identity = 85/252 (33.73%), Postives = 131/252 (51.98%), Query Frame = 2

Query:  296 STNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSXXXXXXXXXXXXXXDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLT-FHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESXXXXXXXXXXXXXXXXYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSC 1048
              N+     + +++LG+ ID  +  +L PK  S N ++L ++L +K D  WTSI  P   K    +Y    + +L    D +NLT   +G      + E +  + ++WL+ K++C + YIWEDLG LFWP++ +R  C+N   +SCSWPPGMKC   G   ++ L W+C E     + N +  R    +  R+    +   R   EK       R + +KRLIK TS+  NGY C+W +    I + C CSC
Sbjct:   26 GVNSPGRIPIRVQVLGETIDPILTKDLLPKYHSLNERKLIKILGDKFDPFWTSISRPVMEKYNKLSY----DPRLEQFIDKVNLTNLRNGK-----ISEEMETLLKDWLVDKSSCQVKYIWEDLGNLFWPRFFKRASCINTSVKSCSWPPGMKCHLGGKHMIYYLRWSCYESSQPIQHNNQNPRRPLYQENRKLHNRKPVHRLWTEK------RRKQHLKRLIKKTSVWRNGYMCEWRIKAVNIENICECSC 262

[Close]

BLAST of noggin-like protein 8 vs. Planmine SMEST
Match: SMESG000007405.1 (SMESG000007405.1)

HSP 1 Score: 113.62 bits (283), Expect = 8.935e-29
Identity = 63/194 (32.47%), Postives = 100/194 (51.55%), Query Frame = 2

Query:  491 NYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNR--------RKQRESXXXXXXXXXXXXXXXXYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSC 1048
            N  + ++S+L       N  F +  G +  L   +L   + WL ++++C M+YIW +L P FWP+WI++G+CV+    SCSWPPGM C+A  ++ L +L + CEED    +++         R  R+ R+       +   + R  N +    +  +  R K LI       NG+YCKW    Y +N+ CSCSC
Sbjct:   75 NGTNKIDSRLRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVS--LTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVFQGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNELCSCSC 266

[Close]

BLAST of noggin-like protein 8 vs. Planmine SMEST
Match: SMESG000034704.1 (SMESG000034704.1)

HSP 1 Score: 113.62 bits (283), Expect = 1.136e-28
Identity = 63/194 (32.47%), Postives = 100/194 (51.55%), Query Frame = 2

Query:  491 NYRDMVESKLSVAADALNLTFHDGTGTQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNR--------RKQRESXXXXXXXXXXXXXXXXYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKYLINDKCSCSC 1048
            N  + ++S+L       N  F +  G +  L   +L   + WL ++++C M+YIW +L P FWP+WI++G+CV+    SCSWPPGM C+A  ++ L +L + CEED    +++         R  R+ R+       +   + R  N +    +  +  R K LI       NG+YCKW    Y +N+ CSCSC
Sbjct:   96 NGTNKIDSRLRNLIKMKNFVFKNKRGEKMNLTSDILDSIKLWLEEESSCQMEYIWHELEPSFWPRWIKKGLCVS--LTSCSWPPGMSCKAKKTKNLDLLQFRCEEDPKKIKYDADERAMQQLRLTRQKRQYKIYNRKRGVFQGRSNNSRRVVTKREKEVRTKMLIFSLREYMNGFYCKWVKTLYYVNELCSCSC 287

The following BLAST results are available for this feature:

BLAST of noggin-like protein 8 vs. Ensembl Human
BLAST of noggin-like protein 8 vs. Ensembl Celegans
BLAST of noggin-like protein 8 vs. Ensembl Fly
BLAST of noggin-like protein 8 vs. Ensembl Zebrafish
BLAST of noggin-like protein 8 vs. Ensembl Xenopus
BLAST of noggin-like protein 8 vs. Ensembl Mouse
BLAST of noggin-like protein 8 vs. UniProt/SwissProt
BLAST of noggin-like protein 8 vs. TrEMBL
BLAST of noggin-like protein 8 vs. Ensembl Cavefish
BLAST of noggin-like protein 8 vs. Ensembl Sea Lamprey
BLAST of noggin-like protein 8 vs. Ensembl Yeast
BLAST of noggin-like protein 8 vs. Ensembl Nematostella
BLAST of noggin-like protein 8 vs. Ensembl Medaka
BLAST of noggin-like protein 8 vs. Planmine SMEST

BLAST of noggin-like protein 8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
NOG	4.673e-10	33.33	noggin [Source:HGNC Symbol;Acc:HGNC:7866]	[more]

BLAST of noggin-like protein 8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nog1	3.640e-10	32.00	noggin 1 [Source:NCBI gene;Acc:30174]	[more]
nog3	5.974e-9	29.60	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	5.974e-9	29.60	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	5.974e-9	29.60	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog2	2.229e-8	38.24	noggin 2 [Source:NCBI gene;Acc:30185]	[more]

BLAST of noggin-like protein 8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nog4	1.286e-13	41.43	noggin 4 [Source:NCBI gene;Acc:733455]	[more]
nog	1.475e-12	35.35	noggin [Source:NCBI gene;Acc:493191]	[more]
acad10	1.587e-8	39.71	acyl-CoA dehydrogenase family member 10 [Source:Xe...	[more]

BLAST of noggin-like protein 8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Nog	3.148e-10	33.33	noggin [Source:MGI Symbol;Acc:MGI:104327]	[more]

BLAST of noggin-like protein 8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P49011\|NOGG_XENLA	5.178e-11	34.34	Noggin OS=Xenopus laevis OX=8355 GN=nog PE=1 SV=1	[more]
sp\|O93525\|NOGG_CHICK	1.923e-10	34.38	Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1	[more]
sp\|Q9W741\|NOGG1_DANRE	2.191e-9	32.00	Noggin-1 OS=Danio rerio OX=7955 GN=nog1 PE=2 SV=1	[more]
sp\|P97466\|NOGG_MOUSE	2.202e-9	33.33	Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1	[more]
sp\|Q13253\|NOGG_HUMAN	2.244e-9	33.33	Noggin OS=Homo sapiens OX=9606 GN=NOG PE=1 SV=1	[more]

BLAST of noggin-like protein 8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C1JAC8	0.000e+0	100.00	Noggin-like protein 8 OS=Schmidtea mediterranea OX...	[more]
A0A5K3F9N3	7.472e-58	39.08	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A183LAN2	1.370e-56	34.92	Uncharacterized protein OS=Schistosoma margrebowie...	[more]
A0A0R3UM00	7.954e-56	37.76	Uncharacterized protein OS=Mesocestoides corti OX=...	[more]
A0A0R3T561	3.569e-54	36.15	Uncharacterized protein OS=Rodentolepis nana OX=10...	[more]

BLAST of noggin-like protein 8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog3	4.311e-8	38.81	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
ENSAMXT00000051007.1	1.557e-7	36.11	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of noggin-like protein 8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000009391.1	1.495e-18	34.88	pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-...	[more]
nog3	8.872e-10	34.18	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
ENSPMAT00000011420.1	5.277e-9	40.30	pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gen...	[more]
nog2	9.591e-8	34.18	noggin 2 [Source:NCBI gene;Acc:30185]	[more]

BLAST of noggin-like protein 8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin-like protein 8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36981	7.458e-11	36.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36952	4.339e-6	34.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of noggin-like protein 8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog2	1.221e-10	29.51	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog1	1.432e-9	27.78	noggin 1 [Source:NCBI gene;Acc:30174]	[more]

BLAST of noggin-like protein 8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000008387.1	0.000e+0	100.00	SMESG000008387.1	[more]
SMESG000016086.1	1.364e-53	36.93	SMESG000016086.1	[more]
SMESG000017268.1	2.549e-36	33.73	SMESG000017268.1	[more]
SMESG000007405.1	8.935e-29	32.47	SMESG000007405.1	[more]
SMESG000034704.1	1.136e-28	32.47	SMESG000034704.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30026932
GenBank	ACO06233.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30026932 ID=SMED30026932|Name=noggin-like protein 8|organism=Schmidtea mediterranea sexual|type=transcript|length=1189bp
TGTCAAAAACGCAGTTACCGAGCCAGATTAGCCGTTGAAATCAGCCAATA
GGATTCGTGGAATTATTTTTAATCAATATTACAGTGAATTCTCCTTCGCT
TTAAACAGATCTAATTTTATGATGAATCTTTATTCTAGATCATGTCCAGT
TTTATTTGCCACTTTGATAACGTTTCTAAATGCGCTTTATTACGATCCGA
ATGATATGGGTAAAGCCAATGTAAAAGTCAGTGAAGTTTTAAAACGAAAA
GACCCGTTTGGTTATGGGAAAATCCGTCAAGTTCATGATTGGCCGTCGAC
AAATAACGATAAATATACAAAAGTCAATATGAGAATTTTGGGGAAAAATA
TTGATCAAACTGTTCTGAATAATTTGCGACCAAAAATGTCCTCGAAAAAT
CTCAAACGATTGAAACGTCTGCTCCACGAGAAAAGAGACACCGCATGGAC
TTCGATAGATCCACCGAAAACTTTGAAAGAACGAGGGGACAATTATCGAG
ATATGGTGGAATCTAAATTATCCGTCGCAGCGGATGCTTTGAATTTAACG
TTTCATGATGGTACTGGGACTCAATATGTTTTACCGGAACACGTTTTGAG
AATGTTTCGAAATTGGCTGCTGAAAAAAGCTACTTGTGTTATGGATTACA
TTTGGGAAGATCTTGGTCCTTTATTTTGGCCTCAGTGGATTCGTCGAGGC
ATTTGTGTCAATAATTTAGCACAGTCATGCTCATGGCCACCTGGAATGAA
ATGCAGAGCCTCAGGTTCAAGGGCTTTGCATATACTTTATTGGGCATGTG
AAGAAGACGTGAATCTTAGAGAATTCAATAGAAGAAAACAGCGAGAATCA
CGGGAACGAAACAAAAGGAGATGGACAAAAACCAGGCGTCGTCGTCGATA
TCCAAACGAAAAAACTTTTAACAATCAAGAAAACCGAAATAAACGAATAA
AACGATTAATCAAAATGACAAGTTTAGCTTCAAATGGATATTATTGTAAA
TGGGATGTTCATAAATATCTTATTAATGACAAATGTTCCTGTTCTTGTGC
TTAGTTAGACATCTTTTGCACTGTGTAATTAGATTGTATCATTTCGAAAT
CCATTATCCATGTTTATGTTTTCTTTTCTCAGTTCTGGAAACCGAATATC
ATTTTCTCCGAAATATTATTTGTAAGACTTATTTCAAAT

protein sequence of SMED30026932-orf-1

>SMED30026932-orf-1 ID=SMED30026932-orf-1|Name=SMED30026932-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=312bp
MMNLYSRSCPVLFATLITFLNALYYDPNDMGKANVKVSEVLKRKDPFGYG
KIRQVHDWPSTNNDKYTKVNMRILGKNIDQTVLNNLRPKMSSKNLKRLKR
LLHEKRDTAWTSIDPPKTLKERGDNYRDMVESKLSVAADALNLTFHDGTG
TQYVLPEHVLRMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNL
AQSCSWPPGMKCRASGSRALHILYWACEEDVNLREFNRRKQRESRERNKR
RWTKTRRRRRYPNEKTFNNQENRNKRIKRLIKMTSLASNGYYCKWDVHKY
LINDKCSCSCA*

Aliases

The feature 'noggin-like protein 8' has the following synonyms


Synonym
nlg-8

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000044	cephalic ganglia
PLANA:0000072	mouth
PLANA:0000101	muscle cell
PLANA:0000141	dorsal region of the whole animal
PLANA:0000143	ventral region of the whole animal
PLANA:0000418	head
PLANA:0002032	epidermal cell
PLANA:0003104	enteric muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR008717	Noggin
IPR029034	Cystine-knot_cytokine

Vocabulary: **biological process**
Term	Definition
GO:0030514	negative regulation of BMP signaling pathway
GO:0045596	negative regulation of cell differentiation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	PFAM	PF05806	Noggin	coord: 86..310 e-value: 6.2E-20 score: 72.0
None	No IPR available	GENE3D	G3DSA:1.10.287.520		coord: 121..172 e-value: 2.3E-30 score: 108.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 244..261
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 244..268
None	No IPR available	PANTHER	PTHR10494:SF6	NOGGIN	coord: 84..310
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..22 score: 0.617
IPR029034	Cystine-knot cytokine	GENE3D	G3DSA:2.10.90.10		coord: 84..230 e-value: 2.3E-30 score: 108.1
IPR029034	Cystine-knot cytokine	SUPERFAMILY	SSF57501	Cystine-knot cytokines	coord: 86..310
IPR008717	Noggin	PANTHER	PTHR10494	BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN	coord: 84..310

Main menu

noggin-like protein 8

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 18

Owlery

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