HORMA domain-containing protein

Overview


Name	HORMA domain-containing protein
Smed ID	SMED30026877
Length (bp)	1619

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of HORMA domain-containing protein (SMED30026877) t-SNE clustered cells

Violin plots show distribution of expression levels for HORMA domain-containing protein (SMED30026877) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HORMA domain-containing protein (SMED30026877) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HORMA domain-containing protein (SMED30026877) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30026877

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 24

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30026877	h1SMcG0014746	Contig4866	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30026877	h1SMcG0014746	Contig4866	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30026877	h1SMcG0016893	Contig4866	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30026877	h1SMcG0016893	Contig4866	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
X1 cell	SMED30026877	h1SMcG0016893	SmedASXL_015454	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30026877	h1SMcG0016893	SmedASXL_015454	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
Smed sexual biotype	SMED30026877	h1SMcG0016893	Contig10893	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30026877	h1SMcG0016893	Contig10893	newmark_ests	PMID:29674431 Fincher et al., 2018
pharynx	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30026877	h1SMcG0016893	dd_Smed_v4_2201_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30026877	h1SMcG0016893	dd_Smed_v6_2201_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
cholinergic neuron	SMED30026877	h1SMcG0016893	dd_Smed_v6_2201_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
pigment cell	SMED30026877	h1SMcG0016893	dd_Smed_v6_2201_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
testis	SMED30026877	h1SMcG0015046	Contig4867	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
testis	SMED30026877	h1SMcG0015046	Contig4867	newmark_ests	PMID:28434803 Rouhana et al., 2017
testis	SMED30026877	h1SMcG0016893	Contig4867	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
testis	SMED30026877	h1SMcG0016893	Contig4867	newmark_ests	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD1 (HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245])

HSP 1 Score: 188.734 bits (478), Expect = 6.195e-54
Identity = 95/242 (39.26%), Postives = 145/242 (59.92%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TE QSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    1 MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 235

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BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD2 (HORMA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28383])

HSP 1 Score: 183.341 bits (464), Expect = 6.852e-53
Identity = 99/273 (36.26%), Postives = 159/273 (58.24%), Query Frame = 1

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTDK---VSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSE 876
            +FP+  T E +SL  +KKLFA +IS I Y+R +FPE ++ ++HL+ + LKILRED KCPG+  +I W++GCFDAL++ YL+  V+  YTD    + V E Y FKF Y ++  ++  D+ S + S       N+D    IKK+++ L+R L +     +PLP  V +TMKL YY+ +TP DY+P GF+    + F   + E IN ++G V T FHS ++ + T+    +   NN  + + ++       + + E    +  +++   CS+  SE
Sbjct:   20 VFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGT-NNED----IKKASVLLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSE 287

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Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTDK---VSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSE 876
            +FP+  T E +SL  +KKLFA +IS I Y+R +FPE ++ ++HL+ + LKILRED KCPG+  +I W++GCFDAL++ YL+  V+  YTD    + V E Y FKF Y ++  ++  D+ S + S       N+D    IKK+++ L+R L +     +PLP  V +TMKL YY+ +TP DY+P GF+    + F   + E IN ++G V T FHS ++ + T+    +   NN  + + ++       + + E    +  +++   CS+  SE
Sbjct:   20 VFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGT-NNED----IKKASVLLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSE 287

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BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD1 (HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245])

HSP 1 Score: 175.637 bits (444), Expect = 4.094e-49
Identity = 92/242 (38.02%), Postives = 141/242 (58.26%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TE QSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + Y+       YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    1 MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYV-------YTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 228

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BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD1 (HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245])

HSP 1 Score: 119.398 bits (298), Expect = 1.313e-30
Identity = 62/167 (37.13%), Postives = 94/167 (56.29%), Query Frame = 1

Query:  253 SKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +K+  W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    5 NKISRWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 164

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BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: him-3 (High Incidence of Males (Increased X chromosome loss); Meiotic chromosome core protein [Source:UniProtKB/TrEMBL;Acc:G5EBG0])

HSP 1 Score: 62.7734 bits (151), Expect = 1.308e-10
Identity = 53/207 (25.60%), Postives = 92/207 (44.44%), Query Frame = 1

Query:   22 NKMPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQD-----SVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGF 627
            +++P+A       W   FP     E+ S +F  +    A + I+  R I  E  F  + ++  KL +    S  P A +V +   G  DA+ + YL+   I FY    + D + E ++F+F YG +     S++  +D    +   L+A   + D  + +  ST+  L   I      +PLP+    + + + Y E  P DY P G+
Sbjct:   13 SEIPIA-----SQWKATFPVDLEIEKNSEMFALRYIKCASAFILDRRGILDEKCFKTRTID--KLLVTAFQSSVPAAKRVSSTFDGLRDAIQQGYLREFAIVFYKKPNEED-INEVFAFRFAYGDEGEIFVSLNNGIDTNESSQELLQAKFVDTDNTKQMFASTIKKLHRCI---KKMEPLPQGSDASFR-VSYTEKAPKDYTPEGY 207

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Query:   22 NKMPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQD-----SVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGF 627
            +++P+A       W   FP     E+ S +F  +    A + I+  R I  E  F  + ++  KL +    S  P A +V +   G  DA+ + YL+   I FY    + D + E ++F+F YG +     S++  +D    +   L+A   + D  + +  ST+  L   I      +PLP+    + + + Y E  P DY P G+
Sbjct:   13 SEIPIA-----SQWKATFPVDLEIEKNSEMFALRYIKCASAFILDRRGILDEKCFKTRTID--KLLVTAFQSSVPAAKRVSSTFDGLRDAIQQGYLREFAIVFYKKPNEED-INEVFAFRFAYGDEGEIFVSLNNGIDTNESSQELLQAKFVDTDNTKQMFASTIKKLHRCI---KKMEPLPQGSDASFR-VSYTEKAPKDYTPEGY 207

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BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: htp-1 (Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q20305])

HSP 1 Score: 60.8474 bits (146), Expect = 8.769e-10
Identity = 57/231 (24.68%), Postives = 111/231 (48.05%), Query Frame = 1

Query:   52 EKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTD------SGLEAVIKNDDAPETIKKSTLSLLRTL-ILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETI-NAKLGHVETDFHSFRM 720
            +K WSK+FP I +   +S  FM +   VA S ++  R+I  +  +F K+    KLK +    + P ++++   +R   DA    +LK V +    +  D +  IE +S KF Y ++   V   +T K        + L  ++   +  ++++   ++++R++  L     +PLPE+     +L Y ++  P ++  +GF   D + F    + I +A +GH+    H+  M
Sbjct:   21 DKKWSKLFPRIVSDPDRSSNFMTRAIYVAFSAVLRNRNILGQ-EYFTKNYITEKLKCMTLCFRNPRSNQIAQLLRNAGDATKDGFLKEVSLVITNNEGDLE-AIEVFSMKFIYFENGGVVARLSTDKNGQEDPHFAKLAQLVY--EGGDSVRDQMVTIVRSVQFLCTKVLEPLPEEFTANFRLEYTND-APSNFRIDGFE--DSSTFYTLPDDIQSATIGHLRPGCHAANM 244

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BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: htp-2 (Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q95XC8])

HSP 1 Score: 57.7658 bits (138), Expect = 9.342e-9
Identity = 55/229 (24.02%), Postives = 103/229 (44.98%), Query Frame = 1

Query:   52 EKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTY---GQDSVSVKLDNTSKTDSGLEAVIK-NDDAPETIKKSTLSLLRTL-ILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINA-KLGHVETDFHSFRM 720
            +KTWSK+FP+I +   +S  FM +   V  S ++  R+I  E  +F K+     L  +    K   A ++   +R   DA    +LK + +   T+       IE +S KF Y   G     +  DN  + D     + +   +  E+++   ++++R++  L     +PLP +     +L Y ++  P ++  +GF   D + F    + I +  +GH+    H+  M
Sbjct:   21 DKTWSKLFPSIVSDPDRSSNFMIRAIYVVFSAVLRQRNIL-EKEYFSKNYITENLSCMTLSFKNLRAHQIAQLLRAAGDATKDGFLKEISL-VVTEHDGDVEAIEVFSMKFIYFENGGVVARLSTDNNDQEDPHFAELAQLRYEGAESVRDQMVTIVRSVQFLCTKVLEPLPAEFTANFRLKYTND-APSNFRIDGFD--DSSTFYTLPDGIQSVTIGHLRPGHHAAHM 244

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BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: set-26 (Histone-lysine N-methyltransferase set-26 [Source:UniProtKB/Swiss-Prot;Acc:Q9U263])

HSP 1 Score: 49.6766 bits (117), Expect = 5.790e-6
Identity = 20/52 (38.46%), Postives = 30/52 (57.69%), Query Frame = 1

Query:  871 SEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
            +EE + +RC CG +  DG  I CE CK WQH  C G+  +    + + C++C
Sbjct:  789 AEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSK-YKCEMC 839

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BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: MBD-R2 (gene:FBgn0038016 transcript:FBtr0082611)

HSP 1 Score: 56.6102 bits (135), Expect = 5.423e-8
Identity = 26/65 (40.00%), Postives = 37/65 (56.92%), Query Frame = 1

Query:  877 EEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLK 1071
            +E  + C C   ++DG+MI CE C  WQH  C GI++E  VP+ +VC IC   NP      ++ K
Sbjct:  914 QEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYIC--RNPQRGRDSMRFK 976

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BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: upSET (gene:FBgn0036398 transcript:FBtr0333050)

HSP 1 Score: 52.7582 bits (125), Expect = 8.174e-7
Identity = 20/45 (44.44%), Postives = 27/45 (60.00%), Query Frame = 1

Query:  892 RCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
            RC C    DDG MI C+ C  WQH  C G I+   +PE ++C++C
Sbjct:  856 RCICELTHDDGYMICCDKCSAWQHVDCMG-IDRQNIPEEYMCELC 899

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BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: upSET (gene:FBgn0036398 transcript:FBtr0075768)

HSP 1 Score: 52.7582 bits (125), Expect = 8.174e-7
Identity = 20/45 (44.44%), Postives = 27/45 (60.00%), Query Frame = 1

Query:  892 RCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
            RC C    DDG MI C+ C  WQH  C G I+   +PE ++C++C
Sbjct:  856 RCICELTHDDGYMICCDKCSAWQHVDCMG-IDRQNIPEEYMCELC 899

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BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: ash1 (gene:FBgn0005386 transcript:FBtr0306009)

HSP 1 Score: 51.6026 bits (122), Expect = 2.035e-6
Identity = 33/104 (31.73%), Postives = 51/104 (49.04%), Query Frame = 1

Query:  805 KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNED--RQEICLIR 1110
            KE ++P++       P      S +E  +RC CG  KD+G+MI C  C  WQH+ C    + D   + + C+ C    P     +I L+EF E+  R  + L+R
Sbjct: 1830 KERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTEC---TKADIDADNYQCERC---EPREVDREIPLEEFTEEGHRYYLSLMR 1927

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: ash1 (gene:FBgn0005386 transcript:FBtr0306010)

HSP 1 Score: 51.6026 bits (122), Expect = 2.035e-6
Identity = 33/104 (31.73%), Postives = 51/104 (49.04%), Query Frame = 1

Query:  805 KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNED--RQEICLIR 1110
            KE ++P++       P      S +E  +RC CG  KD+G+MI C  C  WQH+ C    + D   + + C+ C    P     +I L+EF E+  R  + L+R
Sbjct: 1830 KERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTEC---TKADIDADNYQCERC---EPREVDREIPLEEFTEEGHRYYLSLMR 1927

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BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:436630])

HSP 1 Score: 187.193 bits (474), Expect = 7.137e-54
Identity = 94/224 (41.96%), Postives = 138/224 (61.61%), Query Frame = 1

Query:   67 KMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            +M P + + EQQSLV +KKL A+AIS+I Y+R +F E A+  K++  +K+ ILREDS CPGA ++++W++GCFDAL R YL+ V++  Y D  +P  V E Y FK  Y +     ++D  SK    L  +     A +  +KS++ L+R L +      PLP+ V + MKLLYYDE+TP +Y+P GF+  D      E E +N  +G V T FHS +M + T+K
Sbjct:   14 QMLPDVVSNEQQSLVLVKKLLAIAISSITYLRGLFSEKAYGRKYVGELKVYILREDS-CPGAQQIVHWLQGCFDALQRRYLRMVLLSIYCDPDNPQKVTECYQFKIKYTEKGP--QMDFESKNGQSLTKM-----ACDNTQKSSMLLVRKLYMLMQNLGPLPDDVCLNMKLLYYDEVTPQEYQPPGFKEDDNGTLMFEREPVNLTMGEVVTPFHSIKMNVTTEK 229

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: zte38 (zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB-GENE-060312-39])

HSP 1 Score: 164.851 bits (416), Expect = 3.671e-46
Identity = 87/250 (34.80%), Postives = 140/250 (56.00%), Query Frame = 1

Query:   91 TEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETR 840
            TE QSLVF+K++  +A+S+I Y+R IFPE ++  ++LE + +K+L++D   PGA K+I W+ GCFDAL++ YL+ +VIG +T   D + VIESY FKF Y +     ++D  S  +  +   +      E  KK++  L+R L L     + LP  V +TMKL Y D++TP +YEP GF+         E   ++ ++G +++ +H+ ++ +   +            S N      E E ETP L+  R
Sbjct:   21 TEAQSLVFVKRMVVIAVSSITYLRGIFPEDSYRSRYLEDLCIKVLKQDCSSPGAHKLIKWLMGCFDALEKRYLQMLVIGVHTSPHDSNHVIESYQFKFRYSEH--GPQMDILSNVNGDIRVTL------EDTKKASTLLIRKLFLLMQNLEALPTAVHLTMKLYYNDDVTPPEYEPPGFKAGANESLWFEGTAVHFRVGDLQSRYHTMKLRVTAAQSRLGKLQDGGQLSEN------EMEMETPSLHHIR 256

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: phf20l1 (PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-GENE-030131-5837])

HSP 1 Score: 62.003 bits (149), Expect = 1.577e-9
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS+C G++ ED +PE ++C IC D
Sbjct:  821 IVRCICEMDEENGFMIQCEECMCWQHSVCMGLL-EDSIPEQYICYICRD 868

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: phf20l1 (PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-GENE-030131-5837])

HSP 1 Score: 61.6178 bits (148), Expect = 1.824e-9
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS+C G++ ED +PE ++C IC D
Sbjct:  693 IVRCICEMDEENGFMIQCEECMCWQHSVCMGLL-EDSIPEQYICYICRD 740

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: phf20a (PHD finger protein 20, a [Source:ZFIN;Acc:ZDB-GENE-070912-270])

HSP 1 Score: 58.5362 bits (140), Expect = 1.772e-8
Identity = 32/88 (36.36%), Postives = 48/88 (54.55%), Query Frame = 1

Query:  775 SSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADAN 1038
            S +C   E E E +  V+      +   S T S+E   VRC C  ++++  M+ CE C  WQH  C G++EE+ VPE + C IC D++
Sbjct:  558 SESCGWSEDEMEADLDVITSPLSCSSVASTTESQE--TVRCVCEADEENDFMLQCEECLYWQHGTCMGLLEEN-VPERYSCFICRDSS 642

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: gstm1 (glutathione S-transferase mu 1 [Source:Xenbase;Acc:XB-GENE-971384])

HSP 1 Score: 162.54 bits (410), Expect = 1.380e-44
Identity = 86/223 (38.57%), Postives = 129/223 (57.85%), Query Frame = 1

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            + P   TTE QSLV +K+L AV++S I Y+R +FPEYA+  ++LE I +KILRED  CPG+++++ W+ GC+DAL + Y                TV E Y FKF Y   +    +D  S  ++G    I +D     +K++++ L+R L +      PLP  V++TMKL YYDE+TP DY+P GF+  +  G   E E +   +G V T FH  ++ + T+K
Sbjct:   15 ILPNRVTTETQSLVLVKRLLAVSVSCITYLRGLFPEYAYGTRYLEDICVKILREDKSCPGSTQLVKWMLGCYDALQKKY----------------TVTECYQFKFKY--TAFGPTMDFVS--NNGSSTSICSD-----VKRTSVMLIRKLYVLMQNLGPLPNDVYLTMKLFYYDEVTPADYQPPGFKEGNCEGLMFEGEPMYLNVGEVATPFHVLKVKVTTEK 212

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: PHF20L1 (PHD finger protein 20 like 1 [Source:NCBI gene;Acc:100145157])

HSP 1 Score: 60.4622 bits (145), Expect = 5.688e-9
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS C G++EE  +PE +VC IC+D
Sbjct:  559 IVRCVCEIDEENGFMIQCEECLCWQHSACMGLLEES-IPEQYVCYICSD 606

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: PHF20L1 (PHD finger protein 20 like 1 [Source:NCBI gene;Acc:100145157])

HSP 1 Score: 60.077 bits (144), Expect = 7.250e-9
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS C G++EE  +PE +VC IC+D
Sbjct:  571 IVRCVCEIDEENGFMIQCEECLCWQHSACMGLLEES-IPEQYVCYICSD 618

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: PHF20 (PHD finger protein 20 [Source:NCBI gene;Acc:100126218])

HSP 1 Score: 54.6842 bits (130), Expect = 3.336e-7
Identity = 23/49 (46.94%), Postives = 29/49 (59.18%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C    ++  MI CE C  WQH +C G++ ED VPE + C IC D
Sbjct:  634 IVRCMCEVQDENDFMIQCEECLCWQHGVCMGLL-EDNVPEKYKCYICQD 681

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: KMT2E (lysine (K)-specific methyltransferase 2E [Source:NCBI gene;Acc:779539])

HSP 1 Score: 51.9878 bits (123), Expect = 1.759e-6
Identity = 20/46 (43.48%), Postives = 28/46 (60.87%), Query Frame = 1

Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             RC CG   DDG MI C+ C  WQH  C G I+   +P++++C+ C
Sbjct:   99 TRCICGFTHDDGYMICCDKCSVWQHIDCMG-IDRQNIPDIYLCERC 143

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad2 (HORMA domain containing 2 [Source:MGI Symbol;Acc:MGI:1923078])

HSP 1 Score: 183.341 bits (464), Expect = 4.872e-53
Identity = 91/224 (40.62%), Postives = 140/224 (62.50%), Query Frame = 1

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKT-DSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTD 735
            +FP+  T E +SLV +KKLFA  IS I Y+R +FPE ++ D+ L+ + LKILRED KCPG+  +I W++GCFDAL++ YL   V+  YT+ K+P+ V E Y F+F Y +   ++  D++S + +SG ++        E IKK+   L+R L +      PLP  V +TMKL YY+ +TP DY+P GF+    + F   E E ++ ++G V + FHS ++ + T+
Sbjct:   20 IFPSQVTNEHESLVVVKKLFATCISCITYLRGLFPESSYRDRRLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMAVLTLYTNPKEPEKVTEIYQFRFKYTKKGTTMDFDSSSTSFESGTDS--------EDIKKACSLLIRQLYILMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEAVNSHFLLFEGEPVSLRMGSVSSGFHSMKVKVTTE 235

[Close]

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKT-DSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTD 735
            +FP+  T E +SLV +KKLFA  IS I Y+R +FPE ++ D+ L+ + LKILRED KCPG+  +I W++GCFDAL++ YL   V+  YT+ K+P+ V E Y F+F Y +   ++  D++S + +SG ++        E IKK+   L+R L +      PLP  V +TMKL YY+ +TP DY+P GF+    + F   E E ++ ++G V + FHS ++ + T+
Sbjct:   20 IFPSQVTNEHESLVVVKKLFATCISCITYLRGLFPESSYRDRRLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMAVLTLYTNPKEPEKVTEIYQFRFKYTKKGTTMDFDSSSTSFESGTDS--------EDIKKACSLLIRQLYILMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEAVNSHFLLFEGEPVSLRMGSVSSGFHSMKVKVTTE 235

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad1 (HORMA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915231])

HSP 1 Score: 184.496 bits (467), Expect = 1.185e-52
Identity = 91/233 (39.06%), Postives = 139/233 (59.66%), Query Frame = 1

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQ-----DSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +FP   +TE QSL+F+K+L AV++S I Y+R IFPE A+  ++L+ + +KIL+ED  CPG+S+++ W+ GC+DAL + YL+ +++  YT+  DP T+ E Y FKF Y +     D +S   +N S T S               KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   + +     +G V T FH+FR+ + T+K    N
Sbjct:   16 VFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSA------------DTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMEN 236

[Close]

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQ-----DSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +FP   +TE QSL+F+K+L AV++S I Y+R IFPE A+  ++L+ + +KIL+ED  CPG+S+++ W+ GC+DAL + YL+ +++  YT+  DP T+ E Y FKF Y +     D +S   +N S T S               KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   + +     +G V T FH+FR+ + T+K    N
Sbjct:   16 VFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSA------------DTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMEN 236

[Close]

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQ-----DSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +FP   +TE QSL+F+K+L AV++S I Y+R IFPE A+  ++L+ + +KIL+ED  CPG+S+++ W+ GC+DAL + YL+ +++  YT+  DP T+ E Y FKF Y +     D +S   +N S T S               KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   + +     +G V T FH+FR+ + T+K    N
Sbjct:   16 VFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSA------------DTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMEN 236

[Close]

BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2KIY6|HORM1_BOVIN (HORMA domain-containing protein 1 OS=Bos taurus OX=9913 GN=HORMAD1 PE=2 SV=2)

HSP 1 Score: 191.43 bits (485), Expect = 2.630e-54
Identity = 97/242 (40.08%), Postives = 146/242 (60.33%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TEQQSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D TSK  S    +   D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH+F++ + T++    N
Sbjct:    1 MATAQLQRTSMSALIFPNKISTEQQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALHKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTSNGPV--MDFTSKNQSNEPNMSSAD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVPTPFHTFKVKVTTERERMEN 235

[Close]

BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|A6QQY4|HORM2_BOVIN (HORMA domain-containing protein 2 OS=Bos taurus OX=9913 GN=HORMAD2 PE=2 SV=1)

HSP 1 Score: 188.734 bits (478), Expect = 2.805e-54
Identity = 89/223 (39.91%), Postives = 141/223 (63.23%), Query Frame = 1

Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFR-TCDYAGFRHETETINAKLGHVETDFHSFRMILKTD 735
            +FP+  T E +SL+ +KKLFA +IS I Y+R +FPE ++ ++HL+ + LKILRED KCPG+  +I W++GCFDAL++ YL+  V+  YT+ K+P+ V E Y FKF Y ++  ++  D+++ +        K+    E IKK+++ L+R L +      PLP  V +TM L YY+ +TP+DY+P GF+          E E +N ++G V T FHS ++ + T+
Sbjct:   20 VFPSQITNEHESLIMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLRMAVLTLYTNPKEPEKVTEIYQFKFKYTKEGATMDFDSSNTS-------FKSGTNSEDIKKASVLLIRKLYMLMQNLGPLPNDVILTMTLHYYNAVTPNDYQPPGFKEGVSSHLLLFEGEPVNLQVGMVSTGFHSMKVKVTTE 235

[Close]

BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|E2IUK4|HORM1_PIG (HORMA domain-containing protein 1 OS=Sus scrofa OX=9823 GN=HORMAD1 PE=2 SV=1)

HSP 1 Score: 189.504 bits (480), Expect = 1.438e-53
Identity = 99/244 (40.57%), Postives = 147/244 (60.25%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNY 759
            M  A L +    + +FP   +TEQQSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y   S    +D  SK  S   ++   D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH+F++ + T+K    N Y
Sbjct:    1 MATAQLQRTSMSALVFPNKISTEQQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYT--SNGPIMDFISKNQSSESSMSSAD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVPTPFHTFKVKVTTEKERMENIY 237

[Close]

BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|E2RSQ2|HORM1_CANLF (HORMA domain-containing protein 1 OS=Canis lupus familiaris OX=9615 GN=HORMAD1 PE=3 SV=1)

HSP 1 Score: 189.504 bits (480), Expect = 1.568e-53
Identity = 97/242 (40.08%), Postives = 146/242 (60.33%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TEQQSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   ++   D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH+F++ + T+K    N
Sbjct:    1 MATAQLQRTSMSALVFPNKISTEQQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYASNGPV--MDFISKNQSSESSMSSAD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVPTPFHTFKVKVTTEKERMEN 235

[Close]

BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q86X24|HORM1_HUMAN (HORMA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=HORMAD1 PE=1 SV=1)

HSP 1 Score: 188.734 bits (478), Expect = 2.975e-53
Identity = 95/242 (39.26%), Postives = 145/242 (59.92%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TE QSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    1 MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 235

[Close]

BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A3Q0KSN1 (HORMA domain-containing protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 342.043 bits (876), Expect = 6.731e-108
Identity = 205/536 (38.25%), Postives = 294/536 (54.85%), Query Frame = 1

Query:   28 MPVALLTKEK--TWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKD--PD-----TVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---------KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNL----KATDIKLKEFN-EDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTK---NKGCDLIYCFYNNFFRLSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  A+  K+    WSKMFP     E QSLVF+KKLFAVA+S ++Y R IFPE AF DK LEGI+LKIL+E S  P +SK++ W++GCFDA+DRH+LK+  I  Y+  KD  P       +IESY F+ +YGQ+ +S+ L   +K +S     I +    E  +K+TLSLL+ +  AG     LP ++ +TMKL YYDE+TP+ Y P GF+  D   F  E + IN +LG+V+T  HS +M ++T +   + + VKS+KS+  ++   E         K NE   L+ + +     S     E +  RCPCG NKDDG+MI+C+ C  WQH++CF I++E  VP  HVC+ICA   P L      TD  ++  + E R+  CL RR L  C + D + P  +A  LG+E  V +G+F+ L+KE  +    P+R  K    +  + I C    FF  + + DK ++ S  +           +P KR       + SK T     +E        SQD       +KRRK  +A TP+
Sbjct:    1 MATAVAVKQNIGNWSKMFPNELGVEIQSLVFIKKLFAVAVSYVLYFRDIFPESAFHDKQLEGIELKILKESSMLPASSKIVYWLKGCFDAIDRHFLKSATIALYSADKDLHPSEFCEYNIIESYCFRLSYGQEKLSLDLKTENKRESSTLCEISDFSEIEA-RKATLSLLKNIQTAGERLSKLPSELMITMKLQYYDEVTPESYVPPGFKRADNVSFNFEEDNINIRLGNVKTAHHSIKMHIQTSRRLLSGS-VKSTKSTQEDESIHELSLGSLNASKVNENDDLSLSFQQQTLVSDENESESYEARCPCGVNKDDGVMILCDGCDKWQHAVCFRILQEGDVPTSHVCEICAKLKPELLRTGGTTDETIQNLSVEARKATCLFRRVLALCLNEDSVSPAFIARSLGIEYTVARGLFNRLIKEQVIKGAGPRRGEKLVEKEYLENIVC--PRFFSHNSLHDKTSMVSPQMLTAQKPTTIRRTPGKRAH-----DASKSTSEKEYDE----LFNPSQDYRASPTTSKRRKMDMANTPI 523

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BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A5K4EXM2 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 341.273 bits (874), Expect = 8.962e-108
Identity = 203/534 (38.01%), Postives = 295/534 (55.24%), Query Frame = 1

Query:   28 MPVALLTKEK--TWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKD--PD-----TVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---------KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNL----KATDIKLKEFN-EDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTKNKGCDLIYCFYNNFFRLSKVVDKVALESLVLNKYF-NSVVENNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  A+  K+    WSKMFP     E QSLVF+KKLFAVA+S ++Y R IFPE AF DK LEGI+LKIL+E S  P +SK++ W++GCFDA+DRH+LK+  I  Y+  KD  P       +IESY F+ +YGQ+ +S+ L   +K +S     I +    E  +K+TLSLL+ +  AG     LP ++ +TMKL YYDE+TP+ Y P GF+  D   F  E + IN +LG+V+T  HS +M ++T +   + + VKS+KS+  ++   E         K NE   L+ + +     S     E +  RCPCG NKDDG+MI+C+ C  WQH++CF I++E  VP  HVC+ICA   P L      TD  ++  + E R+  CL RR L  C + D + P  +A  LG+E  V +G+F+ L+KE  +    P+R                     K+V+K  LE++V  ++F ++ + + +  KR       + SK T     +E        SQD       +KRRK  +A TP+
Sbjct:    1 MATAVAVKQNIGNWSKMFPNELGVEIQSLVFIKKLFAVAVSYVLYFRDIFPESAFHDKQLEGIELKILKESSMLPASSKIVYWLKGCFDAIDRHFLKSATIALYSADKDLHPSEFCEYNIIESYCFRLSYGQEKLSLDLKTENKRESSTLCEISDFSEIEA-RKATLSLLKNIQTAGERLSKLPSELMITMKLQYYDEVTPESYVPPGFKRADNVSFNFEEDNINIRLGNVKTAHHSIKMHIQTSRRLLSGS-VKSTKSTQEDESIHELSLGSLNASKVNENDDLSLSFQQQTLVSDENESESYEARCPCGVNKDDGVMILCDGCDKWQHAVCFRILQEGDVPTSHVCEICAKLKPELLRTGGTTDETIQNLSVEARKATCLFRRVLALCLNEDSVSPAFIARSLGIEYTVARGLFNRLIKEQVIKGAGPRRG-------------------EKLVEKEYLENIVCPRFFSHNSLHDKTSMKRAH-----DASKSTSEKEYDE----LFNPSQDYRASPTTSKRRKMDMANTPI 504

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BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A504YP75 (HORMA domain-containing protein 2 OS=Fasciola gigantica OX=46835 GN=FGIG_01587 PE=4 SV=1)

HSP 1 Score: 333.569 bits (854), Expect = 2.094e-104
Identity = 208/551 (37.75%), Postives = 315/551 (57.17%), Query Frame = 1

Query:   28 MPVALLTKE--KTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFY----------TDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN---------NYVKSSKSS-----------NCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNL----KATDIKLKEFN-EDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTKNKGCDLI--YCFYNNFFRLSKVVDKVALESLVLNKY-FNSVVENNS-PAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  A+  KE   +WS++FPT   TE  SLVF+KKLFAVA+S ++Y+R +FPE AFFDK LEG++LKILRED K P +SKV+ W+RGCFDA+DR +LK+ +I  Y          TD +D   +IESYSFK TY   S+S+++ +T++  S     + N  + E IK++T++LL T+  A +    +PE +F+TM+L Y++E TP+DY P GFR  D   F  +   +N ++G+V+T FHS +M ++T+    +N         N ++ S+ S             +K   E E  + +  ++ +     S T   E + VRCPCG NKDDG+MI+C+ C  WQH++CF I+EE  VP  H+C++C  + PNL      TDI L+    E+R+  CL+RRA++ C S D + P  +A  L V+    +G+F+ L+KEGAL    PKR  K    + +    F   F   SK + +V LES   N+   NS     S P+   R+     L    ++   ++ +   + A +DS +  +  +R++ GIA TP+
Sbjct:    1 MATAVAAKEIVGSWSRLFPTELGTEVYSLVFVKKLFAVAVSYVLYLRRLFPENAFFDKQLEGVRLKILREDVKFPSSSKVVYWLRGCFDAIDRQFLKSAIITLYSQDQSDGISKTDYEDCK-IIESYSFKLTYANSSISLQVLSTNEESSSSTFKLSN-GSNEDIKRATINLLGTIRSACSKLRRIPENLFMTMRLQYFEETTPEDYIPPGFRAADDITFLFDGNPVNLRIGNVQTAFHSIKMNIQTNSEFLSNFKGISLNVDNNIELSQQSVDLDEEVAGVQTQSKSALEDELSSSLRQQSLQ-----SETDQSEMYDVRCPCGVNKDDGVMILCDGCGMWQHAVCFRILEEKDVPSSHICELCCVSKPNLLLDGGLTDITLQGITKENRKSQCLLRRAVLLCASLDSVSPSLIAKNLEVDYTTARGIFNRLVKEGALKDAGPKRGEKLVQKEFLETVVFGRVFQTDSKQLGEV-LESRDANQSPKNSNTPTTSHPSATMRRTPRRKLETPCESFLESQLDCRESQAPEDSPV--QVKRRKRSGIANTPI 541

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BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A4Z2CM86 (HORMA domain-containing protein OS=Schistosoma japonicum OX=6182 GN=EWB00_009285 PE=4 SV=1)

HSP 1 Score: 328.946 bits (842), Expect = 8.903e-103
Identity = 205/538 (38.10%), Postives = 298/538 (55.39%), Query Frame = 1

Query:   28 MPVALLTKEK--TWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDT------VIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---------KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNL----KATDIKLKEFN-EDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTK---NKGCDLIYCFYNNFFRLSKVVDKVALESLVLNKYFN---SVVENNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  AL  K+    WSKMFP     E QSLVF+KKLFAVA+S ++Y R IFPE AF DK LEGI+LKIL+E S  P +SK++ W++GCFDA+DR +LK+  I  Y+  KD  +      V ESY F+ +Y +  +S+ L + +K +      I N    E I+K+TL+LL+ + +A      LP ++ +TMKL YYDE+TP++Y P GF+  D   F  E + IN +LG+V T  HS +M ++T +   + + VKS++S+  ++   E         K NE   L+ + +     S     + +  RCPCG NKDDG+MI+C+ C  WQH++CF I+EE  VP  HVC+ICA   P L      TD  ++  N E R+  CL RRAL  C S D +    +A  LGVE  V +G+F+ L+KE  +    P+R  K    +  + I C    FF  + + +K++L ++V  +      S     +P KR       N SK T +   +E    F   +QDS      +KR+K  +A TP+
Sbjct:    1 MATALEIKQNIGNWSKMFPNELGVELQSLVFIKKLFAVAVSYVLYFRDIFPESAFHDKQLEGIELKILKESSILPASSKIVYWLKGCFDAIDRQFLKSATIALYSTKKDSHSNICEYNVFESYCFRLSYCRKKLSLDLTSENKREPSSVCEISNCSEAE-IRKATLNLLKNIQIASERLSKLPPELMITMKLQYYDEVTPENYVPPGFKRADDVTFTFEEDNINVRLGNVRTVHHSIKMHIQTSRRLLSGS-VKSTQSTQEDESIHELSLCSLGTSKANEKDDLSLSFQQQTLRSNENESQIYEARCPCGVNKDDGVMILCDGCDKWQHAVCFRILEEGDVPTSHVCEICAKLKPELLQAGGITDETIQNLNVEARKATCLFRRALALCLSEDSVSSAFIARSLGVEYTVARGLFNRLIKEQVVKGQGPRRGEKLVEKEYLENIIC--PRFFSCTSLEEKLSLGTMVSPQLLTPQKSTAALRTPGKRA-----YNASKSTVDKECDE----FFHYNQDSE-TSPSSKRKKMDMANTPI 524

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BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A2C9KAD6 (HORMA domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106052935 PE=4 SV=1)

HSP 1 Score: 330.487 bits (846), Expect = 9.184e-103
Identity = 182/426 (42.72%), Postives = 241/426 (56.57%), Query Frame = 1

Query:   55 KTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKT------------------DKVSFTNNYVKSSKSSNCNKPEFEKENETPVLN----ETRKITPNCSRT--------CSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD-ANPNLKATDIKLKEF-NEDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALV 1236
            KTW  +FP    TEQ+S +F+KKL AVAISNI Y+R+IFPE+A+ DK LE + LKILR++S CPGA +VI WV+GCFDALD+ YLK ++IG Y D  DP++VIESY+FKF+Y          N  K  S   +        E  KK+T+ LLRTL++  NT   LP+ V +TMKL YYDE+TP DYEP GFR  + + F    E  N  +G V T FH  ++ +KT                  D+V   +N    ++S+   +   EK      LN      +K++P    +          EE F VRCPCG N+DDG+M+MC  CK WQH ICF I  ED+ P  H+CD+CA   N  L+ TD  L      +RQ  CL RR L  C     I   QL+  LG++ NV +G+ + L KE  L+
Sbjct:   13 KTWESIFPNEQVTEQKSALFVKKLLAVAISNITYLRAIFPEHAYGDKSLEDLNLKILRDESSCPGACQVIKWVKGCFDALDKKYLKTLIIGIYIDPNDPESVIESYTFKFSYNNHGEIDIYRNDKKVSSAYSS--------EETKKATIRLLRTLVILTNTLTSLPDNVMMTMKLFYYDEVTPADYEPPGFRPANDSAFHFAEEATNIAIGEVVTPFHMVKLRIKTGSKQFEFEDEPVEVMEHSDQVMSISNAGLDNESNMLQEITSEKAKSVSALNIELKGDKKLSPTQPDSKKSPGKPKPDEENFLVRCPCGCNEDDGLMVMCSCCKFWQHGICFLIKSEDKAPTDHICDVCAKPGNAKLEPTDSYLSSLCTVERQGTCLWRRTLSACLEYKRIIAPQLSRRLGIDNNVAQGLINRLEKEKFLI 430

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BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:103046361])

HSP 1 Score: 189.504 bits (480), Expect = 3.353e-55
Identity = 92/225 (40.89%), Postives = 140/225 (62.22%), Query Frame = 1

Query:   64 SKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            S+M P +  TEQQSLV +KKL A+A+S+I Y+R +FPE A+  K++E  K+ ILRE   CPGAS+++ W++GCFDAL + YL+ +++  Y+D + P  V E Y F+  Y +     +LD  SK    +  +  ND     IKK+++ L+R L        PLP+ V + MKL YYDE+TP+DY+P GF+  + +    E E +N  +G V T FH+ ++ + T+K
Sbjct:   14 SQMLPRVVATEQQSLVVVKKLLAIAVSSITYLRGLFPEKAYGSKYIEEQKVMILREQRTCPGASQIVQWLQGCFDALQKRYLRLILLSIYSDPEFPQKVTECYQFRIQYTEK--GPRLDFESKNQKRVTKMDCND-----IKKASILLVRKLYTLMQNLGPLPDSVCLNMKLSYYDEVTPEDYQPVGFKEGNNSTLVFEKEPVNLTMGEVVTPFHTLKVDVTTEK 231

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:103046361])

HSP 1 Score: 189.119 bits (479), Expect = 8.567e-55
Identity = 92/225 (40.89%), Postives = 140/225 (62.22%), Query Frame = 1

Query:   64 SKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            S+M P +  TEQQSLV +KKL A+A+S+I Y+R +FPE A+  K++E  K+ ILRE   CPGAS+++ W++GCFDAL + YL+ +++  Y+D + P  V E Y F+  Y +     +LD  SK    +  +  ND     IKK+++ L+R L        PLP+ V + MKL YYDE+TP+DY+P GF+  + +    E E +N  +G V T FH+ ++ + T+K
Sbjct:   14 SQMLPRVVATEQQSLVVVKKLLAIAVSSITYLRGLFPEKAYGSKYIEEQKVMILREQRTCPGASQIVQWLQGCFDALQKRYLRLILLSIYSDPEFPQKVTECYQFRIQYTEK--GPRLDFESKNQKRVTKMDCND-----IKKASILLVRKLYTLMQNLGPLPDSVCLNMKLSYYDEVTPEDYQPVGFKEGNNSTLVFEKEPVNLTMGEVVTPFHTLKVDVTTEK 231

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:103046361])

HSP 1 Score: 189.119 bits (479), Expect = 1.291e-54
Identity = 92/225 (40.89%), Postives = 140/225 (62.22%), Query Frame = 1

Query:   64 SKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            S+M P +  TEQQSLV +KKL A+A+S+I Y+R +FPE A+  K++E  K+ ILRE   CPGAS+++ W++GCFDAL + YL+ +++  Y+D + P  V E Y F+  Y +     +LD  SK    +  +  ND     IKK+++ L+R L        PLP+ V + MKL YYDE+TP+DY+P GF+  + +    E E +N  +G V T FH+ ++ + T+K
Sbjct:   14 SQMLPRVVATEQQSLVVVKKLLAIAVSSITYLRGLFPEKAYGSKYIEEQKVMILREQRTCPGASQIVQWLQGCFDALQKRYLRLILLSIYSDPEFPQKVTECYQFRIQYTEK--GPRLDFESKNQKRVTKMDCND-----IKKASILLVRKLYTLMQNLGPLPDSVCLNMKLSYYDEVTPEDYQPVGFKEGNNSTLVFEKEPVNLTMGEVVTPFHTLKVDVTTEK 231

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BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: zte38 (zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB-GENE-060312-39])

HSP 1 Score: 174.866 bits (442), Expect = 4.855e-50
Identity = 85/222 (38.29%), Postives = 137/222 (61.71%), Query Frame = 1

Query:   61 WSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFR--TCDYAGFRHETETINAKLGHVETDFHSFRM 720
            W  +F     T++QSLVF+K++  +A+S+I Y+R IFPE A+  ++LE + +K++RED   P A + + W+ GCFDAL++ YL+ V+IG + D  D + VIESY FKF Y +    + +      ++ +E  +  +D     KK+++ L+R L L     D LP++V++TMKL YYD++TP DYEP GF+   CD   F  E   ++ ++G + T FH  ++
Sbjct:   23 WDSLFQQELRTQEQSLVFVKRMLVLAVSSITYLRGIFPEDAYRSRYLEDLCIKVIREDCSSPAACRTVKWMMGCFDALEKEYLQIVLIGVHRDPDDTNHVIESYQFKFKYSEHGPQMDI----LRNNSMEMSVTMEDT----KKASVLLIRKLFLLMQNLDALPDEVYLTMKLYYYDDVTPPDYEPPGFKEGVCDSLWF--EGTAVHFRVGDLHTPFHVLKV 234

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BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: phf20l1 (PHD finger protein 20 like 1 [Source:NCBI gene;Acc:103026102])

HSP 1 Score: 62.003 bits (149), Expect = 1.115e-9
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS+C G++ ED +PE ++C IC D
Sbjct:  750 IVRCICEMDEENGFMIQCEECMCWQHSVCMGLL-EDSIPEQYICYICRD 797

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BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009606.1 (pep scaffold:Pmarinus_7.0:GL481528:14094:14964:-1 gene:ENSPMAG00000008686.1 transcript:ENSPMAT00000009606.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.8702 bits (185), Expect = 4.055e-17
Identity = 34/92 (36.96%), Postives = 53/92 (57.61%), Query Frame = 1

Query:  478 ETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            E  K++T+ L+R L +     D +PE V +TMKL YYDE+TP+DY+P GFR         + +    ++GHV + FHS ++ +  D+    N
Sbjct:   15 EETKRATILLIRKLFVLMQHLDEMPEDVSLTMKLFYYDEVTPEDYQPPGFRASSTDPLNFQGDPATLRVGHVASTFHSMKLRITVDRSQVDN 106

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004065.1 (pep scaffold:Pmarinus_7.0:GL479372:18838:35317:1 gene:ENSPMAG00000003707.1 transcript:ENSPMAT00000004065.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.003 bits (149), Expect = 1.868e-10
Identity = 24/49 (48.98%), Postives = 32/49 (65.31%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC CG N++ G MI CE C  WQHS+C G  EE+ +P+ + C +C D
Sbjct:  646 IVRCSCGINEETGFMIQCEMCSCWQHSVCMGFTEEN-IPDRYSCHVCQD 693

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Match: kmt2e (lysine (K)-specific methyltransferase 2E [Source:ZFIN;Acc:ZDB-GENE-030131-4120])

HSP 1 Score: 54.6842 bits (130), Expect = 3.248e-8
Identity = 21/46 (45.65%), Postives = 28/46 (60.87%), Query Frame = 1

Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             RC CG   DDG MI C+ C  WQH  C G I+  R+P+ ++C+ C
Sbjct:  117 TRCVCGFTHDDGYMICCDKCSVWQHIDCMG-IDRQRIPDTYLCEFC 161

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Yeast
Match: HOP1 (Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein-DNA filaments [Source:SGD;Acc:S000001334])

HSP 1 Score: 73.1738 bits (178), Expect = 3.537e-14
Identity = 90/422 (21.33%), Postives = 174/422 (41.23%), Query Frame = 1

Query:  100 QSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHL-----------------EGIKLKILREDSKCPGASKVINWV-RGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETI-----KKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDY---AGFRHETETINAKL--GHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---KENETPVLNETRKITP----------------NCSRTCSEEEFFV---------RCPCGGN--KDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINV 1191
            QS   ++ +  ++   + ++R +FP+  F D+                     IK+K L    K   A  +++W+ +G F ++    LKA+ +G +  ++DP  ++E+Y F F Y +++      N S    G +     D   ETI     ++    L+R  I+   + +PLP+K F+TM+L++ D +  +DY+P  F+   +   A  +  T   N  +  G + T  H   + + +   + T++  K+  ++      F+   ++ E   L E+    P                N S+   +   FV          C CG    K   ++  C++C+   H IC+G      + +   C       P+L   D K  +F    Q++ +IR+   +        P  + +++   INV
Sbjct:   21 QSQKLLQTMLTMSFGCLAFLRGLFPDDIFVDQRFVPEKVEKNYNKQNTSQNNSIKIKTLIR-GKSAQADLLLDWLEKGVFKSIRLKCLKALSLGIF--LEDPTDLLENYIFSFDYDEENNVNINVNLSGNKKGSKNA---DPENETISLLDSRRMVQQLMRRFIIITQSLEPLPQKKFLTMRLMFNDNVD-EDYQPELFKDATFDKRATLKVPTNLDNDAIDVGTLNTKHHKVALSVLS---AATSSMEKAGNTNFIRVDPFDLILQQQEENKLEESVPTKPQNFVTSQTTNVLGNLLNSSQASIQPTQFVSNNPVTGICSCECGLEVPKAATVLKTCKSCRKTLHGICYGNFLHSSIEKCFTCIF----GPSL---DTKWSKF----QDLMMIRKVFRFLVRKKKGFPASITELIDSFINV 421

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Yeast
Match: SET3 (Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication [Source:SGD;Acc:S000001737])

HSP 1 Score: 54.6842 bits (130), Expect = 2.798e-8
Identity = 19/47 (40.43%), Postives = 29/47 (61.70%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             + C C  N DDG  I C++C  WQH+IC+GI +    P+ ++C+ C
Sbjct:  117 IITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAPDDYLCNSC 163

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
Match: EDO47610 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLI6])

HSP 1 Score: 234.572 bits (597), Expect = 1.698e-70
Identity = 154/453 (34.00%), Postives = 225/453 (49.67%), Query Frame = 1

Query:   46 TKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNG-------FRTCDYAGFRHETETINAKLGHVETDFHSFRMI---LKTDKV---SFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNE-DRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGCDLIYCFYNNFFRLSKVVDKVALESLVLNKYF 1362
            +K  +WS +FP    TEQQS++F+KKL AVA+S++ Y+R+IFPE+AF D+ LE + LKIL++DS CPGA +VI W++GCFDALD+ YL+ +VIG Y D  DPDT+IESY+FK  +        LD      S ++  IK +     +K+       T + AG     L        + +  D   P D+  N        F   D             K    ++D  S +++   ++ DKV   S     ++ S      +   +   ETP + E  + T +           V C CG N+DDG+MIMC  CK W+H++C+GI++E++ P+ HVC  C       + TD  L E    + Q   L RRAL+ C     I P  ++  LGVE+ V  G+ + L KEG  V    K K               RL K+V+K  L+   L +Y 
Sbjct:   11 SKTVSWSSIFPPEQVTEQQSVLFVKKLLAVAVSSVSYLRAIFPEHAFGDRRLEDLNLKILKDDSACPGACQVIQWIKGCFDALDKKYLRMIVIGIYADADDPDTIIESYTFKNNH-------HLDTDPDITSRVKLRIKTELHQFELKEDDEEDDTTGVNAGG----LIRNNADVDEGMEEDSQMPLDHTDNTPVTHSREFEAVDDHTPPTTPTETTRKSAKRQSD--SQQVVPDGMECDKVPIESPNTPGLRGSAGGVSTRASSQPSGETPNIEEDMQKTDDT----------VSCACGYNEDDGLMIMCGICKFWEHAVCYGILQEEQAPDFHVCAKCCRKPGQPQCTDALLGELGSVELQAAALWRRALLACSEMSRILPTTMSRRLGVEMTVAHGLVNKLEKEG-FVRSAAKGK---------------RLGKIVNKTMLKEEELKEYI 424

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
Match: EDO37170 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGK9])

HSP 1 Score: 50.0618 bits (118), Expect = 1.992e-6
Identity = 20/48 (41.67%), Postives = 30/48 (62.50%), Query Frame = 1

Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
            +RC C  +++ G MI CE C  WQHS C G+ E   VP  ++C +C++
Sbjct:  179 IRCRCNLSEEGGFMIQCEQCLTWQHSECVGLTEL-TVPSKYLCYVCSN 225

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: hormad1 (HORMA domain-containing protein 1 [Source:NCBI gene;Acc:101155880])

HSP 1 Score: 167.933 bits (424), Expect = 5.376e-47
Identity = 85/237 (35.86%), Postives = 130/237 (54.85%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            M  A   K    +++ P    TEQQS+V +KKL A+A+S I Y+R IFP  A+  K++E  ++ IL     CPGA ++I+W++GCFDA+ + +L+ V++  Y D ++P  V E Y F+  Y   S    +D  S ++  L      +      KK+++ L+R L        PLPE V + MKL YYD++TP DY+P GFR  +      E E +   +G V T FH  +  + T+K
Sbjct:    1 MAFAQRVKSSQVTQLLPNEVVTEQQSIVVVKKLLAIAVSAITYLRGIFPGKAYGTKYVEDQQVMILTGGRSCPGADQIIDWMQGCFDAIQKKFLRTVIMSIYNDPENPQKVTEYYQFRIQY--TSNGAHMDFESNSNQKLSTTTYGN-----TKKASILLVRKLYTLMQNLGPLPENVCLNMKLTYYDDVTPQDYQPPGFREAEGDVLEFEKEPVKLTMGEVTTPFHCVKFDMATEK 230

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: zte38 (HORMA domain-containing protein 1-like [Source:NCBI gene;Acc:101175349])

HSP 1 Score: 165.236 bits (417), Expect = 8.762e-47
Identity = 77/205 (37.56%), Postives = 126/205 (61.46%), Query Frame = 1

Query:  124 LFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            + AVA+S+I Y+R IFPEYA+  ++L  + +K+L E+   PGASKV+ W+ G FDAL++ YL+ + IG YTD ++P+ +IE+Y F F Y +    + +      +  ++  ++N       K++++ L+R L L     D LP KV++TMKL YYD+ITP DY+P GF+   Y     E   ++ K+G V T +H+ R+ +  ++
Sbjct:    1 MMAVAVSSITYLRGIFPEYAYRSRYLADMCIKVLHENGNTPGASKVVKWLMGSFDALEKQYLQVISIGVYTDPENPNCIIEAYQFNFRYTEKGPEMNILRNKNVE--MQVTLEN------TKQASVLLIRKLFLLMQNLDALPNKVYLTMKLYYYDDITPADYQPPGFKEGVYDHLWFEGMPVHFKVGEVHTSYHALRVQVSVEQ 197

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: hormad1 (HORMA domain-containing protein 1 [Source:NCBI gene;Acc:101155880])

HSP 1 Score: 152.91 bits (385), Expect = 1.735e-41
Identity = 82/237 (34.60%), Postives = 125/237 (52.74%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            M  A   K    +++ P    TEQQS+V +KKL A+A+S I Y+R IFP  A+  K++E  ++ IL     CPGA ++I+W++GCFDA+ + +L+ V++           V E Y F+  Y   S    +D  S ++  L      +      KK+++ L+R L        PLPE V + MKL YYD++TP DY+P GFR  +      E E +   +G V T FH  +  + T+K
Sbjct:    1 MAFAQRVKSSQVTQLLPNEVVTEQQSIVVVKKLLAIAVSAITYLRGIFPGKAYGTKYVEDQQVMILTGGRSCPGADQIIDWMQGCFDAIQKKFLRTVIMS---------KVTEYYQFRIQY--TSNGAHMDFESNSNQKLSTTTYGN-----TKKASILLVRKLYTLMQNLGPLPENVCLNMKLTYYDDVTPQDYQPPGFREAEGDVLEFEKEPVKLTMGEVTTPFHCVKFDMATEK 221

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: kmt2e (lysine methyltransferase 2E [Source:NCBI gene;Acc:101162568])

HSP 1 Score: 53.5286 bits (127), Expect = 4.913e-7
Identity = 21/47 (44.68%), Postives = 28/47 (59.57%), Query Frame = 1

Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
              RC CG   DDG MI C+ C  WQH  C GI  ++ +PE ++C+ C
Sbjct:  116 ITRCICGFTHDDGYMICCDKCSAWQHIDCMGIDRQN-IPETYLCERC 161

[Close]

BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: kmt2e (lysine methyltransferase 2E [Source:NCBI gene;Acc:101162568])

HSP 1 Score: 52.7582 bits (125), Expect = 7.008e-7
Identity = 21/46 (45.65%), Postives = 28/46 (60.87%), Query Frame = 1

Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             RC CG   DDG MI C+ C  WQH  C GI  ++ +PE ++C+ C
Sbjct:   53 TRCICGFTHDDGYMICCDKCSAWQHIDCMGIDRQN-IPETYLCERC 97

[Close]

BLAST of HORMA domain-containing protein vs. Planmine SMEST
Match: SMESG000066514.1 (SMESG000066514.1)

HSP 1 Score: 988.793 bits (2555), Expect = 0.000e+0
Identity = 489/513 (95.32%), Postives = 489/513 (95.32%), Query Frame = 1

Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGCDLIYCFYNNFFRLSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPVISSNH 1566
            MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKG             LSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSIN           DSLIVEKCNKRRKGGIATTPVISSNH
Sbjct:    1 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKG-------------LSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSIN-----------DSLIVEKCNKRRKGGIATTPVISSNH 489

The following BLAST results are available for this feature:

BLAST of HORMA domain-containing protein vs. Ensembl Human
BLAST of HORMA domain-containing protein vs. Ensembl Celegans
BLAST of HORMA domain-containing protein vs. Ensembl Fly
BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
BLAST of HORMA domain-containing protein vs. Ensembl Mouse
BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
BLAST of HORMA domain-containing protein vs. TrEMBL
BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
BLAST of HORMA domain-containing protein vs. Ensembl Yeast
BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
BLAST of HORMA domain-containing protein vs. Ensembl Medaka
BLAST of HORMA domain-containing protein vs. Planmine SMEST

BLAST of HORMA domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HORMAD1	6.195e-54	39.26	HORMA domain containing 1 [Source:HGNC Symbol;Acc:...	[more]
HORMAD2	6.852e-53	36.26	HORMA domain containing 2 [Source:HGNC Symbol;Acc:...	[more]
HORMAD2	6.852e-53	36.26	HORMA domain containing 2 [Source:HGNC Symbol;Acc:...	[more]
HORMAD1	4.094e-49	38.02	HORMA domain containing 1 [Source:HGNC Symbol;Acc:...	[more]
HORMAD1	1.313e-30	37.13	HORMA domain containing 1 [Source:HGNC Symbol;Acc:...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
him-3	1.308e-10	25.60	High Incidence of Males (Increased X chromosome lo...	[more]
him-3	1.308e-10	25.60	High Incidence of Males (Increased X chromosome lo...	[more]
htp-1	8.769e-10	24.68	Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q2...	[more]
htp-2	9.342e-9	24.02	Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q9...	[more]
set-26	5.790e-6	38.46	Histone-lysine N-methyltransferase set-26 [Source...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MBD-R2	5.423e-8	40.00	gene:FBgn0038016 transcript:FBtr0082611	[more]
upSET	8.174e-7	44.44	gene:FBgn0036398 transcript:FBtr0333050	[more]
upSET	8.174e-7	44.44	gene:FBgn0036398 transcript:FBtr0075768	[more]
ash1	2.035e-6	31.73	gene:FBgn0005386 transcript:FBtr0306009	[more]
ash1	2.035e-6	31.73	gene:FBgn0005386 transcript:FBtr0306010	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hormad1	7.137e-54	41.96	HORMA domain containing 1 [Source:NCBI gene;Acc:43...	[more]
zte38	3.671e-46	34.80	zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB...	[more]
phf20l1	1.577e-9	48.98	PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-...	[more]
phf20l1	1.824e-9	48.98	PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-...	[more]
phf20a	1.772e-8	36.36	PHD finger protein 20, a [Source:ZFIN;Acc:ZDB-GENE...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gstm1	1.380e-44	38.57	glutathione S-transferase mu 1 [Source:Xenbase;Acc...	[more]
PHF20L1	5.688e-9	51.02	PHD finger protein 20 like 1 [Source:NCBI gene;Acc...	[more]
PHF20L1	7.250e-9	51.02	PHD finger protein 20 like 1 [Source:NCBI gene;Acc...	[more]
PHF20	3.336e-7	46.94	PHD finger protein 20 [Source:NCBI gene;Acc:100126...	[more]
KMT2E	1.759e-6	43.48	lysine (K)-specific methyltransferase 2E [Source:N...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hormad2	4.872e-53	40.63	HORMA domain containing 2 [Source:MGI Symbol;Acc:M...	[more]
Hormad2	4.872e-53	40.63	HORMA domain containing 2 [Source:MGI Symbol;Acc:M...	[more]
Hormad1	1.185e-52	39.06	HORMA domain containing 1 [Source:MGI Symbol;Acc:M...	[more]
Hormad1	1.185e-52	39.06	HORMA domain containing 1 [Source:MGI Symbol;Acc:M...	[more]
Hormad1	1.185e-52	39.06	HORMA domain containing 1 [Source:MGI Symbol;Acc:M...	[more]

BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q2KIY6\|HORM1_BOVIN	2.630e-54	40.08	HORMA domain-containing protein 1 OS=Bos taurus OX...	[more]
sp\|A6QQY4\|HORM2_BOVIN	2.805e-54	39.91	HORMA domain-containing protein 2 OS=Bos taurus OX...	[more]
sp\|E2IUK4\|HORM1_PIG	1.438e-53	40.57	HORMA domain-containing protein 1 OS=Sus scrofa OX...	[more]
sp\|E2RSQ2\|HORM1_CANLF	1.568e-53	40.08	HORMA domain-containing protein 1 OS=Canis lupus f...	[more]
sp\|Q86X24\|HORM1_HUMAN	2.975e-53	39.26	HORMA domain-containing protein 1 OS=Homo sapiens ...	[more]

BLAST of HORMA domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3Q0KSN1	6.731e-108	38.25	HORMA domain-containing protein OS=Schistosoma man...	[more]
A0A5K4EXM2	8.962e-108	38.01	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
A0A504YP75	2.094e-104	37.75	HORMA domain-containing protein 2 OS=Fasciola giga...	[more]
A0A4Z2CM86	8.903e-103	38.10	HORMA domain-containing protein OS=Schistosoma jap...	[more]
A0A2C9KAD6	9.184e-103	42.72	HORMA domain-containing protein OS=Biomphalaria gl...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hormad1	3.353e-55	40.89	HORMA domain containing 1 [Source:NCBI gene;Acc:10...	[more]
hormad1	8.567e-55	40.89	HORMA domain containing 1 [Source:NCBI gene;Acc:10...	[more]
hormad1	1.291e-54	40.89	HORMA domain containing 1 [Source:NCBI gene;Acc:10...	[more]
zte38	4.855e-50	38.29	zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB...	[more]
phf20l1	1.115e-9	48.98	PHD finger protein 20 like 1 [Source:NCBI gene;Acc...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ENSPMAT00000009606.1	4.055e-17	36.96	pep scaffold:Pmarinus_7.0:GL481528:14094:14964:-1 ...	[more]
ENSPMAT00000004065.1	1.868e-10	48.98	pep scaffold:Pmarinus_7.0:GL479372:18838:35317:1 g...	[more]
kmt2e	3.248e-8	45.65	lysine (K)-specific methyltransferase 2E [Source:Z...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
HOP1	3.537e-14	21.33	Meiosis-specific protein required for chromosome s...	[more]
SET3	2.798e-8	40.43	Defining member of the SET3 histone deacetylase co...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO47610	1.698e-70	34.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37170	1.992e-6	41.67	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hormad1	5.376e-47	35.86	HORMA domain-containing protein 1 [Source:NCBI gen...	[more]
zte38	8.762e-47	37.56	HORMA domain-containing protein 1-like [Source:NCB...	[more]
hormad1	1.735e-41	34.60	HORMA domain-containing protein 1 [Source:NCBI gen...	[more]
kmt2e	4.913e-7	44.68	lysine methyltransferase 2E [Source:NCBI gene;Acc:...	[more]
kmt2e	7.008e-7	45.65	lysine methyltransferase 2E [Source:NCBI gene;Acc:...	[more]

BLAST of HORMA domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000066514.1	0.000e+0	95.32	SMESG000066514.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30026877 ID=SMED30026877|Name=HORMA domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1619bp
GAAATTTTTCAAATAATCTGAAACAAAATGCCTGTTGCTCTACTAACAAA
AGAAAAGACATGGTCCAAAATGTTTCCTACTATATTTACAACAGAACAGC
AAAGTTTAGTATTTATGAAAAAATTGTTTGCAGTTGCCATTTCTAATATA
GTGTACATCAGATCGATTTTTCCTGAATATGCTTTTTTTGATAAGCATTT
GGAGGGTATAAAGCTAAAAATTCTTAGGGAAGATAGCAAATGTCCTGGAG
CGTCTAAAGTGATAAATTGGGTTAGAGGCTGTTTTGATGCTTTAGATCGA
CATTATTTGAAAGCAGTTGTGATTGGATTTTATACAGACATTAAAGATCC
AGATACAGTAATCGAATCGTATTCATTTAAATTCACTTATGGTCAAGATT
CTGTATCTGTAAAACTTGATAATACTTCCAAGACCGATTCCGGATTAGAA
GCTGTCATTAAAAATGATGATGCGCCAGAGACAATAAAAAAATCTACCTT
AAGTTTGCTCCGAACTTTGATTTTAGCTGGAAATACTCAGGACCCTTTGC
CAGAAAAGGTTTTTGTTACAATGAAATTGCTTTATTATGACGAAATTACT
CCTGACGATTATGAGCCCAATGGGTTTCGAACGTGTGACTATGCCGGTTT
TAGACACGAAACTGAAACTATTAATGCTAAATTAGGTCATGTTGAAACTG
ATTTTCACAGTTTCCGAATGATATTAAAAACGGATAAAGTATCATTTACT
AATAATTACGTAAAAAGTTCTAAAAGTAGTAACTGCAATAAGCCTGAATT
TGAAAAAGAAAATGAAACGCCTGTTTTAAATGAAACAAGAAAAATCACGC
CAAACTGTAGCAGGACTTGCTCTGAAGAGGAGTTTTTTGTCAGATGTCCT
TGTGGGGGAAACAAGGATGATGGAATTATGATAATGTGTGAAAATTGTAA
AAATTGGCAACACTCTATCTGTTTTGGAATTATAGAGGAAGATCGTGTTC
CTGAAGTTCATGTGTGTGATATATGCGCAGACGCCAACCCGAATTTGAAA
GCCACGGATATTAAATTGAAAGAGTTCAATGAAGACCGACAAGAGATTTG
CTTAATACGCAGAGCGTTGATTTATTGCAAGTCATCTGATGTTATCGAAC
CTGGACAATTAGCTGATGTATTAGGTGTTGAAATAAATGTTGGTAAAGGA
GTTTTTCACACATTGCTTAAAGAAGGAGCTTTAGTTAATCCTAAAAGAAA
AACAAAAAATAAAGGGTGTGATCTAATTTACTGTTTTTATAATAATTTTT
TTAGACTTTCAAAAGTTGTTGACAAAGTTGCTTTAGAATCCCTTGTATTA
AATAAATATTTTAATTCTGTCGTTGAAAATAATTCACCAGCAAAAAGAAA
GCGAAAAATTGATGAAGTAAACTTATCAAAATTTACGGATAATATGTCCA
TTAATGAAAACAACCTTAATTTTGCTATTGCATCCCAGGATTCATTAATC
GTTGAAAAATGCAATAAAAGAAGAAAAGGGGGGATTGCTACAACACCTGT
TATATCTTCGAATCATTAATGTGTTGTGTTTAGTTTTTAATAGTTATTAA
AATAAATTCTTTAAAATTA

protein sequence of SMED30026877-orf-1

>SMED30026877-orf-1 ID=SMED30026877-orf-1|Name=SMED30026877-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=514bp
MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPE
YAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIG
FYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAP
ETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGF
RTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKS
SNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGI
MIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEF
NEDRQEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEG
ALVNPKRKTKNKGCDLIYCFYNNFFRLSKVVDKVALESLVLNKYFNSVVE
NNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRK
GGIATTPVISSNH*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000070	intestinal phagocyte
PLANA:0000099	neuron
PLANA:0000463	cholinergic neuron
PLANA:0002075	pigment cell
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036570	HORMA_dom_sf
IPR001965	Znf_PHD
IPR013083	Znf_RING/FYVE/PHD
IPR003511	HORMA_dom
IPR011011	Znf_FYVE_PHD

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001965	Zinc finger, PHD-type	SMART	SM00249	PHD_3	coord: 289..334 e-value: 9.4E-4 score: 28.5
IPR036570	HORMA domain superfamily	GENE3D	G3DSA:3.30.900.10		coord: 10..279 e-value: 2.4E-74 score: 251.8
IPR036570	HORMA domain superfamily	SUPERFAMILY	SSF56019	The spindle assembly checkpoint protein mad2	coord: 21..233
IPR003511	HORMA domain	PFAM	PF02301	HORMA	coord: 26..227 e-value: 7.5E-55 score: 185.8
IPR003511	HORMA domain	PROSITE	PS50815	HORMA	coord: 24..233 score: 33.095
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 286..353 e-value: 1.5E-16 score: 61.6
None	No IPR available	PANTHER	PTHR46462:SF3	UPSET, ISOFORM A	coord: 253..335
None	No IPR available	PANTHER	PTHR46462	FAMILY NOT NAMED	coord: 253..335
IPR011011	Zinc finger, FYVE/PHD-type	SUPERFAMILY	SSF57903	FYVE/PHD zinc finger	coord: 281..340