Ribosomal protein S6 kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30026874 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 427.557 bits (1098), Expect = 1.737e-144 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 428.328 bits (1100), Expect = 1.824e-144 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 17 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFR--HINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 369
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 427.943 bits (1099), Expect = 1.641e-143 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB2 (ribosomal protein S6 kinase B2 [Source:HGNC Symbol;Acc:HGNC:10437]) HSP 1 Score: 418.313 bits (1074), Expect = 2.360e-140 Identity = 205/385 (53.25%), Postives = 272/385 (70.65%), Query Frame = 1
Query: 112 SDKDSMSFGAIRE---EKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERL-GYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
S D+ +R E EE +L S+ + + + PH FE+L V+G+GGYGKVF VRKV G + K+YAMKVL+KA+IVRN KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L GGELFT+LEREG +E+ ACFY+AEI+LA+GHLHS+GIIYRDLKPEN++L GH+KLTDFGL KES T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ T++KI+R L P Y + D L+K LKRNP +R+ G D +++ H FF+ +NWDD+L+ +V+PPF+P L+SE DVS FD+ FT Q P+ SPDD+ + + F GF+YVAP+V +S+
Sbjct: 24 SPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHC------FELLRVLGKGGYGKVFQVRKVQ-GTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK-TMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRH--MNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSI 398
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Match: RPS6KB1 (ribosomal protein S6 kinase B1 [Source:HGNC Symbol;Acc:HGNC:10436]) HSP 1 Score: 389.037 bits (998), Expect = 1.127e-128 Identity = 199/357 (55.74%), Postives = 248/357 (69.47%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGK A IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGK------------------------AMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 399
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rsks-1 (Ribosomal protein S6 kinase beta [Source:UniProtKB/Swiss-Prot;Acc:Q9NAH6]) HSP 1 Score: 395.971 bits (1016), Expect = 3.012e-131 Identity = 196/357 (54.90%), Postives = 259/357 (72.55%), Query Frame = 1
Query: 184 VTQSIEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS---TNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAE 1239
+ +SI++C +NP + +V DF++L V+G+GGYGKVF VRK T G D +++AMKVL+KA IVRN+KDTAHTK+ERNILE ++ PF+ L YAFQ+ LY++L Y GGELF +LEREG MEN A FY++EI +++ HLH +GIIYRDLKPEN+LLD GHVKLTDFGL KE T+TFCGTIEYMAPEIL R GH VDWWSLG L+FDML+GGPPF+ E+ ++ TI+KIL+ L P Y S + LIK LLKR+ RLG +D EEIKSH FF+ D W+ + +R++E PFKP+++++ D S FD+ FT P+ SP ++ + ++ F GF+YVAP+V E
Sbjct: 60 MMESIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTT-GSDNGQIFAMKVLQKATIVRNQKDTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRK-TIDKILKGRLTLPAYLSNEARDLIKKLLKRHVDTRLGAGLSDAEEIKSHAFFKTTD--WNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDSPCETNFSLNGDNPFVGFTYVAPSVLE 412
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 333.569 bits (854), Expect = 5.906e-105 Identity = 179/387 (46.25%), Postives = 245/387 (63.31%), Query Frame = 1
Query: 148 EEKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS---TNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNV-------AESVLSEPWIENKP 1275
EEK D E ++ + C + +P + FE+L V+G+G +GKVFLVRKV G D +YAMKVLKKA + +D TK ERNIL I HPF+VKLHYAFQ++ LY++L + GG+LFT L +E E+ FY+AE++LA+ HLHS GI+YRDLKPEN+LLD GH+K+TDFGLSKE+ S T +FCGT+EYMAPE++ R GH+ D+WSLG L+F+ML+G PF Q + T+ +IL+A L P + + + L++ L KRN + RLG D VEEIK H FF K I++ +L+++++PPFKP L + S FD FT + P SP + +IF GFS+V+ V A+SV S P + P
Sbjct: 19 EEKTDSSSETEIDIGDVRKCGEKADPRQ------FELLKVLGQGSFGKVFLVRKVR-GRDSGHVYAMKVLKKATL--KVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPF-QGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAK--IDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASAN-GHEIFRGFSFVSNAVMEERKLIAKSVRSVPTAKTNP 392 HSP 2 Score: 108.227 bits (269), Expect = 2.874e-24 Identity = 86/296 (29.05%), Postives = 148/296 (50.00%), Query Frame = 1
Query: 169 EENQLVTQSIE-ICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTL-MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLD-KCG---HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKIL------RAPLKFPMY--FSLDVMGLIKGLLKRNPKERLGYKNDVE 1005
EE +L+ +S+ + NP D+EIL IG G + +V K +K YA+K++KKA E+ +L H F+VKL ++ ++ +Y++ C GGEL L + +L E + +A + A+ +LHS+ + +RDL N+L K G +++ DFG +K+S T C T +++APE+LR++G+ D WSLG LL ML+G PF+ + T ++IL + + P++ S + L++ +L +P R+ K ++
Sbjct: 373 EERKLIAKSVRSVPTAKTNPFTD----DYEILEKIGNGAHS---VVHKCQMKATRRK-YAVKIVKKAVFDATEEVDI-------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPND--TPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQ 651
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 328.176 bits (840), Expect = 6.807e-103 Identity = 177/385 (45.97%), Postives = 243/385 (63.12%), Query Frame = 1
Query: 154 KYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS---TNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNV-------AESVLSEPWIENKP 1275
K D E ++ + C + +P + FE+L V+G+G +GKVFLVRKV G D +YAMKVLKKA + +D TK ERNIL I HPF+VKLHYAFQ++ LY++L + GG+LFT L +E E+ FY+AE++LA+ HLHS GI+YRDLKPEN+LLD GH+K+TDFGLSKE+ S T +FCGT+EYMAPE++ R GH+ D+WSLG L+F+ML+G PF Q + T+ +IL+A L P + + + L++ L KRN + RLG D VEEIK H FF K I++ +L+++++PPFKP L + S FD FT + P SP + +IF GFS+V+ V A+SV S P + P
Sbjct: 59 KTDSSSETEIDIGDVRKCGEKADPRQ------FELLKVLGQGSFGKVFLVRKVR-GRDSGHVYAMKVLKKATL--KVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPF-QGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAK--IDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASAN-GHEIFRGFSFVSNAVMEERKLIAKSVRSVPTAKTNP 430 HSP 2 Score: 107.457 bits (267), Expect = 5.168e-24 Identity = 76/238 (31.93%), Postives = 123/238 (51.68%), Query Frame = 1
Query: 169 EENQLVTQSIE-ICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTL-MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLD-KCG---HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
EE +L+ +S+ + NP D+EIL IG G + +V K +K YA+K++KKA E+ +L H F+VKL ++ ++ +Y++ C GGEL L + +L E + +A + A+ +LHS+ + +RDL N+L K G +++ DFG +K+S T C T +++APE+LR++G+ D WSLG LL ML+G PF+
Sbjct: 411 EERKLIAKSVRSVPTAKTNPFTD----DYEILEKIGNGAHS---VVHKCQMKATRRK-YAVKIVKKAVFDATEEVDI-------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFA 633
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 328.176 bits (840), Expect = 1.034e-102 Identity = 176/383 (45.95%), Postives = 242/383 (63.19%), Query Frame = 1
Query: 160 DEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS---TNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNV-------AESVLSEPWIENKP 1275
D E ++ + C + +P + FE+L V+G+G +GKVFLVRKV G D +YAMKVLKKA + +D TK ERNIL I HPF+VKLHYAFQ++ LY++L + GG+LFT L +E E+ FY+AE++LA+ HLHS GI+YRDLKPEN+LLD GH+K+TDFGLSKE+ S T +FCGT+EYMAPE++ R GH+ D+WSLG L+F+ML+G PF Q + T+ +IL+A L P + + + L++ L KRN + RLG D VEEIK H FF K I++ +L+++++PPFKP L + S FD FT + P SP + +IF GFS+V+ V A+SV S P + P
Sbjct: 41 DSSSETEIDIGDVRKCGEKADPRQ------FELLKVLGQGSFGKVFLVRKVR-GRDSGHVYAMKVLKKATL--KVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPF-QGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAK--IDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASAN-GHEIFRGFSFVSNAVMEERKLIAKSVRSVPTAKTNP 410 HSP 2 Score: 107.842 bits (268), Expect = 3.211e-24 Identity = 86/296 (29.05%), Postives = 148/296 (50.00%), Query Frame = 1
Query: 169 EENQLVTQSIE-ICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTL-MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLD-KCG---HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKIL------RAPLKFPMY--FSLDVMGLIKGLLKRNPKERLGYKNDVE 1005
EE +L+ +S+ + NP D+EIL IG G + +V K +K YA+K++KKA E+ +L H F+VKL ++ ++ +Y++ C GGEL L + +L E + +A + A+ +LHS+ + +RDL N+L K G +++ DFG +K+S T C T +++APE+LR++G+ D WSLG LL ML+G PF+ + T ++IL + + P++ S + L++ +L +P R+ K ++
Sbjct: 391 EERKLIAKSVRSVPTAKTNPFTD----DYEILEKIGNGAHS---VVHKCQMKATRRK-YAVKIVKKAVFDATEEVDI-------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPND--TPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQ 669
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Match: rskn-1 (Putative ribosomal protein S6 kinase alpha-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21734]) HSP 1 Score: 328.561 bits (841), Expect = 1.478e-102 Identity = 177/385 (45.97%), Postives = 243/385 (63.12%), Query Frame = 1
Query: 154 KYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS---TNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNV-------AESVLSEPWIENKP 1275
K D E ++ + C + +P + FE+L V+G+G +GKVFLVRKV G D +YAMKVLKKA + +D TK ERNIL I HPF+VKLHYAFQ++ LY++L + GG+LFT L +E E+ FY+AE++LA+ HLHS GI+YRDLKPEN+LLD GH+K+TDFGLSKE+ S T +FCGT+EYMAPE++ R GH+ D+WSLG L+F+ML+G PF Q + T+ +IL+A L P + + + L++ L KRN + RLG D VEEIK H FF K I++ +L+++++PPFKP L + S FD FT + P SP + +IF GFS+V+ V A+SV S P + P
Sbjct: 78 KTDSSSETEIDIGDVRKCGEKADPRQ------FELLKVLGQGSFGKVFLVRKVR-GRDSGHVYAMKVLKKATL--KVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPF-QGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAK--IDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASAN-GHEIFRGFSFVSNAVMEERKLIAKSVRSVPTAKTNP 449 HSP 2 Score: 108.612 bits (270), Expect = 2.353e-24 Identity = 86/296 (29.05%), Postives = 148/296 (50.00%), Query Frame = 1
Query: 169 EENQLVTQSIE-ICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTL-MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLD-KCG---HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKIL------RAPLKFPMY--FSLDVMGLIKGLLKRNPKERLGYKNDVE 1005
EE +L+ +S+ + NP D+EIL IG G + +V K +K YA+K++KKA E+ +L H F+VKL ++ ++ +Y++ C GGEL L + +L E + +A + A+ +LHS+ + +RDL N+L K G +++ DFG +K+S T C T +++APE+LR++G+ D WSLG LL ML+G PF+ + T ++IL + + P++ S + L++ +L +P R+ K ++
Sbjct: 430 EERKLIAKSVRSVPTAKTNPFTD----DYEILEKIGNGAHS---VVHKCQMKATRRK-YAVKIVKKAVFDATEEVDI-------LLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPND--TPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQ 708
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6k (gene:FBgn0283472 transcript:FBtr0077114) HSP 1 Score: 416.387 bits (1069), Expect = 7.768e-140 Identity = 203/357 (56.86%), Postives = 262/357 (73.39%), Query Frame = 1
Query: 190 QSIEICDQTVNPHK-KVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKE---SATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
++I++C++ VNP K K+ DFE+ V+G+GGYGKVF VRK T G D K +AMKVLKKA IV N+KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L Y GGELF +LEREG +E+ CFY++EI LA+GHLH GIIYRDLKPEN+LLD GHVKLTDFGL KE T+TFCGTIEYMAPEIL R GH VDWWSLG L+FDML+G PPF+ E+ K+ TIE IL+A L P Y + + L++ L+KR +RLG D ++ H FF+ +NWDD+L+R++EPP KP L+SE DVS FD+ FT Q P+ SPDD+T + + IF GF+YVAP++ E +
Sbjct: 56 ETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRK-TAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKK-TIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKH--VNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSILEDM 408
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6k (gene:FBgn0283472 transcript:FBtr0333264) HSP 1 Score: 416.387 bits (1069), Expect = 7.768e-140 Identity = 203/357 (56.86%), Postives = 262/357 (73.39%), Query Frame = 1
Query: 190 QSIEICDQTVNPHK-KVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKE---SATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
++I++C++ VNP K K+ DFE+ V+G+GGYGKVF VRK T G D K +AMKVLKKA IV N+KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L Y GGELF +LEREG +E+ CFY++EI LA+GHLH GIIYRDLKPEN+LLD GHVKLTDFGL KE T+TFCGTIEYMAPEIL R GH VDWWSLG L+FDML+G PPF+ E+ K+ TIE IL+A L P Y + + L++ L+KR +RLG D ++ H FF+ +NWDD+L+R++EPP KP L+SE DVS FD+ FT Q P+ SPDD+T + + IF GF+YVAP++ E +
Sbjct: 56 ETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRK-TAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKK-TIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKH--VNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSILEDM 408
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0333715) HSP 1 Score: 311.997 bits (798), Expect = 4.285e-95 Identity = 164/344 (47.67%), Postives = 223/344 (64.83%), Query Frame = 1
Query: 226 HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKE--SATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHIS---EDIFTGFSYVAPNVAE 1239
H K FE+L V+G G +GKVFLVRK+ G+D LYAMKVLKKA + KD + +ER IL + H F+V+LHYAFQ+ LY++L + GG+LFT L +E E FY+AE++LA+ HLH+ GIIYRDLKPEN+LLD+ GH+ LTDFGLSK+ + T +FCGT+EYMAPEI+ R+GH F DWWS G L+++ML+G PF + ++Q T+ +ILR+ L P S + L++ L KRNP+ RLG + +IK+H FF I+W + ++V PPF P + S D FD +T++ SP DS G IS +IF GFS+VAP + E
Sbjct: 191 HDKADPSQFELLRVLGEGSFGKVFLVRKII-GKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQ-TRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFAT--IDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSK----SPRDSPGGPISASAHEIFRGFSFVAPVLLE 523 HSP 2 Score: 110.153 bits (274), Expect = 1.049e-24 Identity = 68/212 (32.08%), Postives = 111/212 (52.36%), Query Frame = 1
Query: 247 DFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERN--ILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGH----VKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
++ +L +GRG F V ++ KK YA+KV++KA + T+ E +L HP +V L+ ++ + Y+V+ GGEL + G + E++A + I+ A+ +LH G+++RDLKP N++ +KL D G +K+ T C T ++APE+L+R+G+ D WSLG LL+ MLSG PF+
Sbjct: 567 EYNLLQELGRG----TFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFA 774
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0077360) HSP 1 Score: 311.997 bits (798), Expect = 4.285e-95 Identity = 164/344 (47.67%), Postives = 223/344 (64.83%), Query Frame = 1
Query: 226 HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKE--SATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHIS---EDIFTGFSYVAPNVAE 1239
H K FE+L V+G G +GKVFLVRK+ G+D LYAMKVLKKA + KD + +ER IL + H F+V+LHYAFQ+ LY++L + GG+LFT L +E E FY+AE++LA+ HLH+ GIIYRDLKPEN+LLD+ GH+ LTDFGLSK+ + T +FCGT+EYMAPEI+ R+GH F DWWS G L+++ML+G PF + ++Q T+ +ILR+ L P S + L++ L KRNP+ RLG + +IK+H FF I+W + ++V PPF P + S D FD +T++ SP DS G IS +IF GFS+VAP + E
Sbjct: 191 HDKADPSQFELLRVLGEGSFGKVFLVRKII-GKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQ-TRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFAT--IDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSK----SPRDSPGGPISASAHEIFRGFSFVAPVLLE 523 HSP 2 Score: 110.153 bits (274), Expect = 1.049e-24 Identity = 68/212 (32.08%), Postives = 111/212 (52.36%), Query Frame = 1
Query: 247 DFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERN--ILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGH----VKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
++ +L +GRG F V ++ KK YA+KV++KA + T+ E +L HP +V L+ ++ + Y+V+ GGEL + G + E++A + I+ A+ +LH G+++RDLKP N++ +KL D G +K+ T C T ++APE+L+R+G+ D WSLG LL+ MLSG PF+
Sbjct: 567 EYNLLQELGRG----TFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFA 774
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Match: JIL-1 (gene:FBgn0020412 transcript:FBtr0076237) HSP 1 Score: 297.36 bits (760), Expect = 6.734e-88 Identity = 165/349 (47.28%), Postives = 221/349 (63.32%), Query Frame = 1
Query: 235 VSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEII-RHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSK----ESATSTNTFCGTIEYMAPEILRR--EGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLK----FPMYFSLDVMGLIKGLLKRNPKERLGYKN-DVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
VS+ DF+I+ V+G G YG+VFLVRK+T D KLYAMKVL K +V+ K HTK+ER +LE I R+PFLV LHYAFQS S LY+VL + GGELFT+L E++ YIAE+ LA+ LH GIIYRD+K EN+LLD GH+ L+DFGLSK E+ ++FCGT+EYMAPEI+R GH VDWWS+G L F++L+G PF+ S Q+ +I R K P FS + + +L++NPK RLG + D EIK H FF N INW ++ +++ + P+KP L +E DV F + FT+Q P D+ + I +F G++YVAP E +
Sbjct: 256 VSLNDFKIIRVLGTGAYGRVFLVRKLT-RHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFAT-SDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFF--NGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPSRIR--LFRGYTYVAPEHLEQM 598 HSP 2 Score: 74.3294 bits (181), Expect = 2.160e-13 Identity = 63/217 (29.03%), Postives = 100/217 (46.08%), Query Frame = 1
Query: 247 DFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYI-AEISLAIGHLHSKGIIYRDLKPENVLLD--KCGHVKLTDFGLSKESATSTNTFCG-------TIEYMAPEILRREG---HTFVVDWWSLGTLLFDMLSGGPPFSQ 858
D E+ T G YG V V D ++ K++ ++ +E D + + L+ H +V H F+ + +IV+ Y G EL + M+ +C I ++ +A+ H+HSK I+ DLKPEN++ + + VKL DFG SA N F T++Y PE+L ++ VD + LG L+ ML G P+ Q
Sbjct: 622 DLELGTRTSNGAYGTCHFV--VDSSTD--LVFLAKIIPLSKFRPSEVDALISCA----LDTTNHKNIVSYHGTFREKCETWIVMEYLSGPELTASIR-----MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIMFENREDRTVKLIDFG----SACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGATLYTMLVGHRPYRQ 821
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6kb1b (ribosomal protein S6 kinase b, polypeptide 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2038]) HSP 1 Score: 423.705 bits (1088), Expect = 1.688e-142 Identity = 215/385 (55.84%), Postives = 276/385 (71.69%), Query Frame = 1
Query: 142 IREEKYDEKEENQLVTQS------------IEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ +++ +E + N+L+ Q IEI + VN + + FE+L V+G+GGYGKVF VRKV+ G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RLG D E+++H FF+ +NWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E++
Sbjct: 16 VSDDELEEAQINELMDQCSGFEFNMDDCEKIEISEDNVNQGTENIRPECFELLRVLGKGGYGKVFQVRKVS-GAATGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRH--VNWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENI 396
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6kb1a (ribosomal protein S6 kinase b, polypeptide 1a [Source:ZFIN;Acc:ZDB-GENE-091113-52]) HSP 1 Score: 413.305 bits (1061), Expect = 2.585e-138 Identity = 215/391 (54.99%), Postives = 274/391 (70.08%), Query Frame = 1
Query: 190 QSIEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVED 1347
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ER+ILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG +E+ ACFY+AEISLA+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN R+G DV +I+ H FF+ INWDD+L+ K++PPFKP L+S DVS FDS FT+Q P+ SPDD+ + +F GF+Y+AP+V E++ + E K + + T VS K VED
Sbjct: 44 EKFEISEDSVNQGTEKIRPECFELLRVLGKGGYGKVFQVRKVA-GAASGKIFAMKVLKKAMIVRNAKDTAHTKAERSILEEVKHPFIVDLIYAFQTGEKLYLILEYLSGGELFMQLEREGIFLEDTACFYLAEISLALGHLHQKGIIYRDLKPENIMLNYNGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDMLTGAPPFTAENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNASVRIGASPRDVLDIQRHSFFRH--INWDDLLAFKIDPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDTKLSESDNQVFLGFTYIAPSVLENIKEKFTFEPKSRSPRKVLGS-PRTPVSPLKAEVED 429
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: BX000486.1 (ribosomal protein S6 kinase b, polypeptide 1a [Source:NCBI gene;Acc:562242]) HSP 1 Score: 413.305 bits (1061), Expect = 2.848e-138 Identity = 215/391 (54.99%), Postives = 274/391 (70.08%), Query Frame = 1
Query: 190 QSIEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVED 1347
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ER+ILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG +E+ ACFY+AEISLA+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN R+G DV +I+ H FF+ INWDD+L+ K++PPFKP L+S DVS FDS FT+Q P+ SPDD+ + +F GF+Y+AP+V E++ + E K + + T VS K VED
Sbjct: 45 EKFEISEDSVNQGTEKIRPECFELLRVLGKGGYGKVFQVRKVA-GAASGKIFAMKVLKKAMIVRNAKDTAHTKAERSILEEVKHPFIVDLIYAFQTGEKLYLILEYLSGGELFMQLEREGIFLEDTACFYLAEISLALGHLHQKGIIYRDLKPENIMLNYNGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDMLTGAPPFTAENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNASVRIGASPRDVLDIQRHSFFRH--INWDDLLAFKIDPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDTKLSESDNQVFLGFTYIAPSVLENIKEKFTFEPKSRSPRKVLGS-PRTPVSPLKAEVED 430
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6kb1b (ribosomal protein S6 kinase b, polypeptide 1b [Source:ZFIN;Acc:ZDB-GENE-040426-2038]) HSP 1 Score: 382.874 bits (982), Expect = 2.965e-126 Identity = 206/407 (50.61%), Postives = 271/407 (66.58%), Query Frame = 1
Query: 142 IREEKYDEKEENQLVTQS------------IEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGEL-------FTYLER--------EGTLMENQAC-------FYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ +++ +E + N+L+ Q IEI + VN + + FE+L V+G+GGYGKVF VRKV+ G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y G L F++ +G + + C FY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RLG D E+++H FF+ +NWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E++
Sbjct: 16 VSDDELEEAQINELMDQCSGFEFNMDDCEKIEISEDNVNQGTENIRPECFELLRVLGKGGYGKVFQVRKVS-GAATGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGLNLCFLEIDNFSFFPHSFCCCGVAKGLIQPLKCCSGLLTCSFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRH--VNWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENI 418
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Match: rps6ka2 (ribosomal protein S6 kinase, polypeptide 2 [Source:ZFIN;Acc:ZDB-GENE-090827-1]) HSP 1 Score: 339.347 bits (869), Expect = 6.629e-107 Identity = 189/438 (43.15%), Postives = 265/438 (60.50%), Query Frame = 1
Query: 166 KEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESA---TSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARF--GHTHVSECKKIVEDDVPGAQQISSNNQTKCV-PISNHSNAINGVSKSYKSPS 1458
K E+ + + +I +K FE+L V+G+G YGKVFLVRK+ G D +LYAMKVLKKA + +D +K ER+IL + HPF+VKLHYAFQ++ LY++L + GG+LFT L +E E FY+AE++LA+ HLHS GIIYRDLKPEN+LLD+ GH+K+TDFGLSKE+ +FCGTIEYMAPE++ R GHT DWWS G L+F+ML+G PF + K+ T+ IL+A L P + S +V L++ L KRNP RLG D VEEIK HIFF I+W+ + R+++PPFKP + D FD FT++ P SP + + +F GFS+VA N+ + +P E K N + + + H ++ ++ ED GA + +CV I++ A+ + +S K PS
Sbjct: 31 KLEDDSILKEFDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKIK-GSDTGQLYAMKVLKKATL--KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKE-TMALILKAKLGMPQFLSPEVQSLLRALFKRNPSNRLGAGPDGVEEIKRHIFFAT--IDWNKLYRREIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSPGVPASAN-AHQLFRGFSFVATNLGQ---EQPLTEIKQNSVNPIVQQLHGNNIHFTDGYELKEDIGIGAYSVCK----RCVHRITSVEYAVKIIDRSKKDPS 454 HSP 2 Score: 102.834 bits (255), Expect = 2.331e-22 Identity = 66/210 (31.43%), Postives = 113/210 (53.81%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKV-FLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVL-LDKCG---HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
+E+ IG G Y V ++T E YA+K+ I R++KD ++ +L +HP ++ L + +Y+V+ GGEL + R+ E +A + I+ + +LHS+G+++RDLKP N+L +D+ G +++ DFG +K+ T C T ++APE+L+++G+ D WSLG LL+ ML+G PF+
Sbjct: 415 YELKEDIGIGAYSVCKRCVHRITSVE-----YAVKI-----IDRSKKDP--SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYVDETGDPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGILLYTMLAGFTPFA 612
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 423.705 bits (1088), Expect = 1.304e-142 Identity = 212/357 (59.38%), Postives = 264/357 (73.95%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D +++ H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDD+T + + +F GF+YVAP+V ESV
Sbjct: 23 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVI-GAHTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFR--HINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESV 375
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 423.32 bits (1087), Expect = 1.666e-142 Identity = 212/357 (59.38%), Postives = 264/357 (73.95%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D +++ H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDD+T + + +F GF+YVAP+V ESV
Sbjct: 15 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVI-GAHTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFR--HINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESV 367
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 423.32 bits (1087), Expect = 4.313e-142 Identity = 212/357 (59.38%), Postives = 264/357 (73.95%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D +++ H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDD+T + + +F GF+YVAP+V ESV
Sbjct: 44 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVI-GAHTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESV 396
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 423.705 bits (1088), Expect = 5.885e-142 Identity = 212/357 (59.38%), Postives = 264/357 (73.95%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D +++ H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDD+T + + +F GF+YVAP+V ESV
Sbjct: 68 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVI-GAHTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESV 420
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Match: l3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:Xenbase;Acc:XB-GENE-1000732]) HSP 1 Score: 422.55 bits (1085), Expect = 6.092e-142 Identity = 212/357 (59.38%), Postives = 264/357 (73.95%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKV G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D +++ H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDD+T + + +F GF+YVAP+V ESV
Sbjct: 37 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVI-GAHTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDAIDVQGHPFFR--HINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVFVGFTYVAPSVLESV 389
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1270849]) HSP 1 Score: 427.557 bits (1098), Expect = 1.383e-143 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 414.461 bits (1064), Expect = 4.302e-139 Identity = 205/385 (53.25%), Postives = 271/385 (70.39%), Query Frame = 1
Query: 112 SDKDSMSFGAIRE---EKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
S D G +R E EE +L S+ + + + PH FE+L+V+G+GGYGKVF VRKV G + K+YAMKVL+KA+IV + KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L GGELFT+LEREG +E+ ACFY+AEI+LA+GHLHS GIIYRDLKPEN++L GH+KLTDFGL KES T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ T++KI++ L P Y + D L K LKRNP +R+G D +++ H FF+ INWDD+L+R+V+PPF+P L+SE DVS FD+ FT Q P+ SPDD+ + + F GF+YVAP+V +S+
Sbjct: 24 SPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHC------FELLSVLGKGGYGKVFQVRKVQ-GTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK-TMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRH--INWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSI 398
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 414.461 bits (1064), Expect = 4.302e-139 Identity = 205/385 (53.25%), Postives = 271/385 (70.39%), Query Frame = 1
Query: 112 SDKDSMSFGAIRE---EKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
S D G +R E EE +L S+ + + + PH FE+L+V+G+GGYGKVF VRKV G + K+YAMKVL+KA+IV + KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L GGELFT+LEREG +E+ ACFY+AEI+LA+GHLHS GIIYRDLKPEN++L GH+KLTDFGL KES T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ T++KI++ L P Y + D L K LKRNP +R+G D +++ H FF+ INWDD+L+R+V+PPF+P L+SE DVS FD+ FT Q P+ SPDD+ + + F GF+YVAP+V +S+
Sbjct: 24 SPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHC------FELLSVLGKGGYGKVFQVRKVQ-GTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK-TMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRH--INWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSI 398
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 395.201 bits (1014), Expect = 7.514e-133 Identity = 196/362 (54.14%), Postives = 256/362 (70.72%), Query Frame = 1
Query: 112 SDKDSMSFGAIRE---EKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDST 1176
S D G +R E EE +L S+ + + + PH FE+L+V+G+GGYGKVF VRKV G + K+YAMKVL+KA+IV + KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L GGELFT+LEREG +E+ ACFY+AEI+LA+GHLHS GIIYRDLKPEN++L GH+KLTDFGL KES T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ T++KI++ L P Y + D L K LKRNP +R+G D +++ H FF+ INWDD+L+R+V+PPF+P L+SE DVS FD+ FT Q P+ SPDD+
Sbjct: 24 SPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHC------FELLSVLGKGGYGKVFQVRKVQ-GTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK-TMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRH--INWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTA 375
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Match: Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1927343]) HSP 1 Score: 395.201 bits (1014), Expect = 7.514e-133 Identity = 196/362 (54.14%), Postives = 256/362 (70.72%), Query Frame = 1
Query: 112 SDKDSMSFGAIRE---EKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDST 1176
S D G +R E EE +L S+ + + + PH FE+L+V+G+GGYGKVF VRKV G + K+YAMKVL+KA+IV + KDTAHT++ERNILE ++HPF+V+L YAFQ+ LY++L GGELFT+LEREG +E+ ACFY+AEI+LA+GHLHS GIIYRDLKPEN++L GH+KLTDFGL KES T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ T++KI++ L P Y + D L K LKRNP +R+G D +++ H FF+ INWDD+L+R+V+PPF+P L+SE DVS FD+ FT Q P+ SPDD+
Sbjct: 24 SPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHC------FELLSVLGKGGYGKVFQVRKVQ-GTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK-TMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRH--INWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTA 375
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P23443|KS6B1_HUMAN (Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2) HSP 1 Score: 427.943 bits (1099), Expect = 7.878e-143 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P67998|KS6B1_RABIT (Ribosomal protein S6 kinase beta-1 OS=Oryctolagus cuniculus OX=9986 GN=RPS6KB1 PE=2 SV=1) HSP 1 Score: 427.557 bits (1098), Expect = 9.068e-143 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|P67999|KS6B1_RAT (Ribosomal protein S6 kinase beta-1 OS=Rattus norvegicus OX=10116 GN=Rps6kb1 PE=1 SV=1) HSP 1 Score: 427.557 bits (1098), Expect = 9.676e-143 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|Q8BSK8|KS6B1_MOUSE (Ribosomal protein S6 kinase beta-1 OS=Mus musculus OX=10090 GN=Rps6kb1 PE=1 SV=2) HSP 1 Score: 427.557 bits (1098), Expect = 9.676e-143 Identity = 215/357 (60.22%), Postives = 267/357 (74.79%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDST + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Match: sp|Q6TJY3|KS6B1_BOVIN (Ribosomal protein S6 kinase beta-1 OS=Bos taurus OX=9913 GN=RPS6KB1 PE=2 SV=1) HSP 1 Score: 426.402 bits (1095), Expect = 2.946e-142 Identity = 214/357 (59.94%), Postives = 266/357 (74.51%), Query Frame = 1
Query: 190 QSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ EI + +VN +K+ FE+L V+G+GGYGKVF VRKVT G + K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKRN RLG D E+++H FF+ INW+++L+RKVEPPFKP L+SE DVS FDS FT Q P+ SPDDS + + +F GF+YVAP+V ESV
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-GANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH--INWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSALSESANQVFLGFTYVAPSVLESV 422
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A4S2MBY0 (Non-specific serine/threonine protein kinase OS=Opisthorchis felineus OX=147828 GN=CRM22_001136 PE=4 SV=1) HSP 1 Score: 533.102 bits (1372), Expect = 9.774e-179 Identity = 274/501 (54.69%), Postives = 347/501 (69.26%), Query Frame = 1
Query: 82 SLTTDNDEKESDKDS----MSFGAIREEK-YDEKEENQLVTQ------SIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLF-------------ARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSKSYKSPSVIEKHNGVIKPSSSDLAL 1512
S+ DND + D++S G+ R E+ +K +N+ ++ ++EIC QTVNP+ +V +F I VIG+GGYGKVFLV+KV G+D+ KLYAMKVLKKAR+V NEKD AHT SERNIL+++RHPFLV+LHYAFQ+ SNLYIVL YCPGGELF YLEREG L+EN ACFY AEI LAIGHLHS GIIYRDLK ENVLLD+ GHVKLTDFGLSKE +TNTFCGTIEYMAPEI+R EGH VDWWSLGTLL+DMLSG PPFSQE SK+ T KIL APLKFP FS +V+ LI+GLL+R+PKERLG K DVEE+K H FF++++INW D+ R++ PPF+P L ++ DVS FD TFT QP++SP +++ I D+F GFSYV P+V E V+ EPW++ R+ + +H +E + DV AQ + S + +P + HS A G+ Y H G ++P+S+ A+
Sbjct: 8 SVEVDNDAEAVDEESECSDAKSGSQRTERNCQQKLQNEPFSEENGRKETVEICQQTVNPNNRVGSENFMIQRVIGKGGYGKVFLVQKVD-GKDKGKLYAMKVLKKARLVCNEKDKAHTVSERNILQMLRHPFLVRLHYAFQNHSNLYIVLEYCPGGELFNYLEREGALLENAACFYTAEIILAIGHLHSLGIIYRDLKSENVLLDRQGHVKLTDFGLSKEGVGTTNTFCGTIEYMAPEIIRCEGHGKAVDWWSLGTLLYDMLSGAPPFSQEESKEATTHKILTAPLKFPPAFSPEVVSLIRGLLRRDPKERLGSKEDVEEVKRHKFFRRHEINWSDVFHRRLRPPFRPKLAADNDVSMFDPTFTRLQPVVSPAENSRP-IPPDMFQGFSYVGPSVCEEVVREPWVDADAGTRRRQYRNQAALSAGRLRRMELAPSHWNEKPQNRLGDVRPAQPVHS--ELTSLPEARHSKA-TGMYNHY------HHHRGQVRPNSTTPAV 497
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A419PD32 (Non-specific serine/threonine protein kinase OS=Clonorchis sinensis OX=79923 GN=Rps6kb2 PE=4 SV=1) HSP 1 Score: 524.242 bits (1349), Expect = 1.180e-175 Identity = 262/455 (57.58%), Postives = 324/455 (71.21%), Query Frame = 1
Query: 190 QSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIR-HPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLF-------------ARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSKSYKSPSVIEKHNGVIKPSSSDLAL 1512
+++EIC QTVNP+ +V +F I VIG+GGYGKVFLV+KV G+D+ KLYAMKVLKKAR+V NEKD AHT SERNIL+++R HPFLV+LHYAFQ+ SNLYIVL YCPGGELF YLEREG L+EN ACFY AEI LAIGHLHS GIIYRDLK ENVLLD+ GHVKLTDFGLSKE +TNTFCGTIEYMAPEI+R EGH VDWWSLGTLL+DMLSG PPFSQE SK+ T KIL APLKFP FS +V+ LI+GLL+R+PKERLG K DVEE+K H FF++++INW D+ R++ PPF+P L ++ DVS FD TFT QP++SP +++ I D+F GFSYV P+V E V+ EPW++ R+ + +H +E + D AQ + S + +P + HS A G+ Y H G +P+S+ A+
Sbjct: 33 ETVEICQQTVNPNNRVGSENFMIQRVIGKGGYGKVFLVQKVD-GKDKGKLYAMKVLKKARLVCNEKDKAHTVSERNILQMLRQHPFLVRLHYAFQNHSNLYIVLEYCPGGELFNYLEREGALLENAACFYTAEIILAIGHLHSLGIIYRDLKSENVLLDRQGHVKLTDFGLSKEGVGTTNTFCGTIEYMAPEIIRCEGHGKAVDWWSLGTLLYDMLSGAPPFSQEESKEATTHKILTAPLKFPPAFSPEVVSLIRGLLRRDPKERLGSKEDVEEVKRHKFFRRHEINWSDVFHRRLRPPFRPKLAADNDVSMFDPTFTRLQPVVSPAENSRP-IPPDMFQGFSYVGPSVCEEVMREPWVDGDAGTRRRQYRNQAALSAGRLRRMELAPSHWNERPQSRLGDARPAQPVHS--ELTSLPEARHSKA-TGMYNHY------HHHRGQARPNSTTPAV 476
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A4E0QV28 (Non-specific serine/threonine protein kinase OS=Fasciola hepatica OX=6192 GN=D915_009964 PE=4 SV=1) HSP 1 Score: 526.554 bits (1355), Expect = 2.247e-175 Identity = 253/379 (66.75%), Postives = 301/379 (79.42%), Query Frame = 1
Query: 154 KYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIE-NKPNRRK 1287
KY +N +++EIC +TVNPH +VS +F I VIG+GGYGKVFLV+KV G D+ KLYAMKVLKKAR+V NEKD AHT SERNIL+++RHPFLV+LHYAFQ+ SNLYIVL YCPGGELF YLEREG L+EN ACFY+AEI LAIGHLHS GIIYRDLK ENVLLD+ GHVKLTDFGLSKE +TNTFCGTIEYMAPEI++ EGH VDWWSLGTLLFDMLSGGPPFSQE S++ T KIL APLKFP FS +V LIKGLLKR+P+ERLG K+DVEE+K H FF++++INW D+ +R+++PPFKP L ++ D S FD TFT QPI+SP D+ G I D+F GFSYVA +V E + + W E N +RR+
Sbjct: 48 KYGLGYDNIDGRETVEICQKTVNPHNRVSSENFNIQRVIGKGGYGKVFLVQKVD-GVDKGKLYAMKVLKKARLVCNEKDKAHTVSERNILQMLRHPFLVRLHYAFQNHSNLYIVLEYCPGGELFNYLEREGALLENAACFYVAEIVLAIGHLHSLGIIYRDLKSENVLLDRQGHVKLTDFGLSKEGVCTTNTFCGTIEYMAPEIIKYEGHGKAVDWWSLGTLLFDMLSGGPPFSQEESREATTHKILTAPLKFPPSFSPEVTSLIKGLLKRDPRERLGSKDDVEEVKRHKFFRRHEINWSDVFNRRLKPPFKPHLLADNDTSMFDPTFTRLQPIVSPSDA-GRSIPTDMFQGFSYVAQSVCEDSVRDTWAEPNSSSRRR 424
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A5K3FAY0 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 515.383 bits (1326), Expect = 5.119e-173 Identity = 244/385 (63.38%), Postives = 305/385 (79.22%), Query Frame = 1
Query: 91 TDNDEKESDKDSMSFGAIREE--KYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAE 1239
+ N+ ++D+ I E Y E +N+ T+ +EIC +TVNPHKKV+ DF++L VIG+GGYG V+LV+K T D+ K YAMKVLKKA+++RNEK+T HT SERNIL++++HPFLV+LHYAFQ++SNLYIVL YCPGGELF YLE E LME+ ACFYI+EI+LAIGHLHS GIIYRDLKPEN+LLDK GHVKLTDFGLSKE +TNTFCGTIEYMAPEI+R GH VDWWSLGTLLFDMLSGGPPFSQE +K+ T EKIL++ +KFP FS + + LI+GLLK++PKERLG KNDVE+IK H FF + +NWDD+ +RK+EPPFKP+L S++DVS FD +FT +PI+SP ++ T I D+F GFS+VA +V E
Sbjct: 26 SSNESAQADEHIPKMKEIEEHINNYSEALQNRPGTEVLEICGETVNPHKKVNAEDFQVLKVIGKGGYGTVYLVQKATKSPDKDKFYAMKVLKKAKLIRNEKNTMHTLSERNILQMLKHPFLVRLHYAFQNRSNLYIVLEYCPGGELFRYLETECFLMEDAACFYISEIALAIGHLHSLGIIYRDLKPENILLDKDGHVKLTDFGLSKEGVCTTNTFCGTIEYMAPEIIRCAGHGRAVDWWSLGTLLFDMLSGGPPFSQEGNKKATAEKILKSQVKFPPSFSTEAIHLIRGLLKKDPKERLGTKNDVEDIKQHSFFVQRGVNWDDVYNRKMEPPFKPELASDSDVSMFDPSFTGMKPIVSPGNTDDT-IPVDLFQGFSFVASSVVE 409
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Match: A0A3Q0KTP5 (Non-specific serine/threonine protein kinase OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 517.694 bits (1332), Expect = 9.490e-173 Identity = 258/429 (60.14%), Postives = 316/429 (73.66%), Query Frame = 1
Query: 97 NDEKESDKDSMSFGAIREEKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKT----------LFARFGHTHVSECKKIVEDDV 1353
N+ K SD+ S +E E +E +++EIC +TVNP+ +V+ +F+I VIG+GGYGKVFLV+KV G D+ KLYAMKVLKKAR+V NEKD AHT SERNILE+++HPFLVKLHYAFQ+ SNLYIVL YC GGELF YLEREG L+EN ACFY +EI LAIGHLHS GIIYRDLK ENVLLD+ GHVKLTDFGLSKE +TNTFCGTIEYMAPEI+R EGH VDWWSLGTL++DMLSG PPFSQE S++ T KIL APLKFP FS +V+ LI+GLLKR+P ERLG K D+EEIK FF++++INW D+ +R+++PPF+P L +E DVS FD +FT QP++SP D G I D+F GFSYVAP+V E L + W +N P+R + R G H++ +I ED V
Sbjct: 33 NNTKSSDQLS------KELICSENKEEITTQETVEICQKTVNPNNRVNAENFKIQRVIGKGGYGKVFLVQKVD-GIDQGKLYAMKVLKKARLVCNEKDKAHTVSERNILEMLQHPFLVKLHYAFQNHSNLYIVLEYCHGGELFNYLEREGALLENAACFYASEIVLAIGHLHSLGIIYRDLKSENVLLDRQGHVKLTDFGLSKEGVCTTNTFCGTIEYMAPEIIRCEGHGKAVDWWSLGTLIYDMLSGTPPFSQEESREATTRKILTAPLKFPPSFSSEVISLIRGLLKRDPNERLGSKEDMEEIKRQKFFKRHEINWSDVYNRRLKPPFRPKLTAENDVSMFDPSFTRLQPVVSPVDG-GASIPPDMFQGFSYVAPSVCEDSLRDNWTDNLPSRHRRHGLRGAMSAGRLRRIGFGHLNAPNRIPEDIV 453
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kb1b (ribosomal protein S6 kinase B1 [Source:NCBI gene;Acc:103035647]) HSP 1 Score: 426.017 bits (1094), Expect = 1.829e-143 Identity = 213/357 (59.66%), Postives = 266/357 (74.51%), Query Frame = 1
Query: 190 QSIEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ IEI + +VN + + FE+L V+G+GGYGKVF VRKVT G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RLG D E+++H FF+ INWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E++
Sbjct: 41 EKIEISEDSVNQGTESIRPECFELLRVLGKGGYGKVFQVRKVT-GGGSGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRH--INWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENI 393
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: ENSAMXT00000004157.2 (ribosomal protein S6 kinase B2 [Source:NCBI gene;Acc:103031203]) HSP 1 Score: 424.091 bits (1089), Expect = 3.201e-143 Identity = 212/380 (55.79%), Postives = 275/380 (72.37%), Query Frame = 1
Query: 169 EENQLVTQSIEICDQTVN-PHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTL 1293
E L T+ +E+ + VN ++V FE+LTV+G+GGYGKVF VRKV G K++AMKVL+KA+IVRN KDTAHT++ER ILE +RHPF+V L YAFQ+ LY++L GGELF LE+EG ME+ ACFY+AEI+LA+GHLHS GIIYRDLKPEN++L+ GH+KLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L+FDM++G PPF+ E+ K+ TI+KIL+ + P Y + D LIK LLK+NP +RLG K D +I+ H FF+ INWDD+L ++VEPP++P L+S+ DVS FDS FT Q P+ SPDD+T + ++ F GF+YVAP+V ES+ +E +P + L
Sbjct: 28 ESEPLETEEVELTSEVVNRDSERVGPDCFELLTVLGKGGYGKVFQVRKVQ-GSQMGKIFAMKVLRKAKIVRNAKDTAHTRAEREILETVRHPFIVDLWYAFQTGGKLYLILECLSGGELFMQLEKEGIFMEDTACFYLAEITLALGHLHSNGIIYRDLKPENIMLNHEGHIKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILNRSGHNRAVDWWSLGALMFDMMTGSPPFTGENRKK-TIDKILKCKICLPPYLTPDARDLIKKLLKKNPSQRLGSGKGDCADIQKHPFFRH--INWDDLLHKRVEPPYRPSLQSDEDVSQFDSRFTRQTPVDSPDDTTLSGSADHAFAGFTYVAPSVLESLKEGFSVEPRPRPVRRL 403
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kb1b (ribosomal protein S6 kinase B1 [Source:NCBI gene;Acc:103035647]) HSP 1 Score: 425.246 bits (1092), Expect = 3.697e-143 Identity = 213/357 (59.66%), Postives = 266/357 (74.51%), Query Frame = 1
Query: 190 QSIEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
+ IEI + +VN + + FE+L V+G+GGYGKVF VRKVT G K++AMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RLG D E+++H FF+ INWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E++
Sbjct: 44 EKIEISEDSVNQGTESIRPECFELLRVLGKGGYGKVFQVRKVT-GGGSGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNNQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLNLPPYLTQEARDLLKRLLKRSASSRLGAGPGDATEVQTHPFFRH--INWDDLLARKVEPPFKPFLQSAEDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENI 396
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kal (ribosomal protein S6 kinase a, like [Source:NCBI gene;Acc:337670]) HSP 1 Score: 333.183 bits (853), Expect = 3.256e-105 Identity = 182/408 (44.61%), Postives = 250/408 (61.27%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCV-PISNHSNAINGVSKSYKSPS 1458
FE+L V+G+G +GKVFLVRK+ G D +LYAMKVLKKA + +D TK ER+IL + HPF+VKLHYAFQ++ LY++L + GG++FT L +E E FY+AE++LA+ HLH+ GI+YRDLKPEN+LLD+ GH+KLTDFGLSKES +FCGT+EYMAPE++ R GHT DWWSLG L+F+ML+G PF Q + T+ IL+A L P + SL+ L++ L KRNP RLG D VEEIK H FF + I+W+ + ++++PPFKP D CFD FT + P SP + + +F GFS+VAP E S P+ N + G S+ ++ ED G+ I +C+ ++ A+ + KS + PS
Sbjct: 69 FELLKVLGQGSFGKVFLVRKIM-GPDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHNLGIVYRDLKPENILLDEAGHIKLTDFGLSKESVDQDRKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPF-QGKDRNETMNMILKAKLGMPQFLSLEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHAFF--STIDWNKLYRQELQPPFKPAAGKPDDTFCFDPEFTAKTPKDSPGIPPSAN-AHQLFKGFSFVAPASLEESKSSPF-----NILPIVQMHSGAAQFSDVYELKEDIGVGSYSICK----RCIHRVTAMEFAVKIIDKSKRDPS 460 HSP 2 Score: 97.0561 bits (240), Expect = 1.132e-20 Identity = 62/210 (29.52%), Postives = 109/210 (51.90%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKV-FLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVL-LDKCGH---VKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
+E+ IG G Y + +VT E +A+K++ K++ R+ + ++ +HP ++ L + +Y+V GGEL + R+ E +A + I+ + +LH +G+++RDLKP N+L +D G+ +++ DFG +K+ T C T ++APE+L R+G+ D WSLG LL+ ML+G PF+
Sbjct: 421 YELKEDIGVGSYSICKRCIHRVTAME-----FAVKIIDKSK--RDPSEEIEI-----LMRYGQHPNIITLKDVYDEGRFVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGDNGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFA 618
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Match: rps6kal (ribosomal protein S6 kinase a, like [Source:NCBI gene;Acc:337670]) HSP 1 Score: 333.954 bits (855), Expect = 4.698e-105 Identity = 182/408 (44.61%), Postives = 250/408 (61.27%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKND-VEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCV-PISNHSNAINGVSKSYKSPS 1458
FE+L V+G+G +GKVFLVRK+ G D +LYAMKVLKKA + +D TK ER+IL + HPF+VKLHYAFQ++ LY++L + GG++FT L +E E FY+AE++LA+ HLH+ GI+YRDLKPEN+LLD+ GH+KLTDFGLSKES +FCGT+EYMAPE++ R GHT DWWSLG L+F+ML+G PF Q + T+ IL+A L P + SL+ L++ L KRNP RLG D VEEIK H FF + I+W+ + ++++PPFKP D CFD FT + P SP + + +F GFS+VAP E S P+ N + G S+ ++ ED G+ I +C+ ++ A+ + KS + PS
Sbjct: 60 FELLKVLGQGSFGKVFLVRKIM-GPDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHNLGIVYRDLKPENILLDEAGHIKLTDFGLSKESVDQDRKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLPF-QGKDRNETMNMILKAKLGMPQFLSLEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHAFF--STIDWNKLYRQELQPPFKPAAGKPDDTFCFDPEFTAKTPKDSPGIPPSAN-AHQLFKGFSFVAPASLEESKSSPF-----NILPIVQMHSGAAQFSDVYELKEDIGVGSYSICK----RCIHRVTAMEFAVKIIDKSKRDPS 451 HSP 2 Score: 97.0561 bits (240), Expect = 1.347e-20 Identity = 62/210 (29.52%), Postives = 109/210 (51.90%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKV-FLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVL-LDKCGH---VKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
+E+ IG G Y + +VT E +A+K++ K++ R+ + ++ +HP ++ L + +Y+V GGEL + R+ E +A + I+ + +LH +G+++RDLKP N+L +D G+ +++ DFG +K+ T C T ++APE+L R+G+ D WSLG LL+ ML+G PF+
Sbjct: 412 YELKEDIGVGSYSICKRCIHRVTAME-----FAVKIIDKSK--RDPSEEIEI-----LMRYGQHPNIITLKDVYDEGRFVYLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSGNPDSIRICDFGFAKQLRGDNGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFA 609
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 288.886 bits (738), Expect = 7.545e-92 Identity = 149/336 (44.35%), Postives = 219/336 (65.18%), Query Frame = 1
Query: 247 DFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNIL-EIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESA---TSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHI-------SEDIFTGFSYV 1221
DF+ LTV+G+G +GKV L + + G YA+KV+KK+ I+ +K+ H +ERN+L + +RHPFLV LHY+FQS LY V+ Y GGELF +L+R+G+ E++A FY AEI AIG+LHS I+YRDLKPEN+LLD GH+ LTDFGL KE ++T TFCGT EY+APE+L++ + VDWW LG +L++ML G PPF ++ KQ+ E IL PL+ + + +++GLL ++P +RLG +D+ EIK+H+FF + INW+D+ ++++ P+ P + D+ FD FT + +S S+ T + D F GF+Y+
Sbjct: 91 DFDFLTVLGKGSFGKVLLAKHKSDG----IFYAVKVMKKS-IILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQM-YESILHQPLQLRPCTTNAAISVLEGLLHKDPHQRLGATSDILEIKNHVFF--STINWNDLDAKRIPSPYNPGVSGPCDLHNFDPAFTAEPLSMSMAQSSDTSSVCANVDEAADAFVGFTYM 418
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 273.092 bits (697), Expect = 3.171e-85 Identity = 150/344 (43.60%), Postives = 207/344 (60.17%), Query Frame = 1
Query: 223 PHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHS-KGIIYRDLKPENVLLDKCGHVKLTDFGLSKESAT---STNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYK-NDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISED-----IFTGFSYVA 1224
P KV+M +F+ L ++G+G +GKV LVR+ G+ YAMK+LKK IV + + AHT +E +L+ +HPFL L Y+FQ+ L V+ Y GGELF +L RE E++ FY AEI A+ +LH+ K ++YRDLK EN++LDK GH+K+ DFGL KE T + TFCGT EY+APE+L + VDWW LG ++++M+ G PF + ++L E IL ++FP S D L+ GLLK++PK+RLG +D +EI H FF I W D+ RK+ PPFKP + SE D FD FT Q ++P D + S D F FSY A
Sbjct: 141 PKSKVTMNNFDYLKLLGKGTFGKVILVREKATGQ----YYAMKILKKEVIVAKD-EVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL-FELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFA--GIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITPPDRFDSMESLDNERRPHFPQFSYCA 476
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001814.1 (pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gene:ENSPMAG00000001637.1 transcript:ENSPMAT00000001814.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 236.498 bits (602), Expect = 1.173e-73 Identity = 119/263 (45.25%), Postives = 171/263 (65.02%), Query Frame = 1
Query: 343 AMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLG-YKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFD 1128
++K K+ ++V+ K HT +E+ IL+ I PFLV+L Y+F+ SNLY+VL Y PGGE+F++L R G E + FY A+I LA +LHS +IYRDLKPEN+L+D+ G++++TDFG +K T T CGT EY+APEI+ +G+ VDWW+LG L+++M +G PPF + Q+ EKI+ ++FP +FS D+ L++ LL+ + +R G KN V +IK+H +F D W I RKVE PF P K D S FD
Sbjct: 8 SLKATKRTKVVK-LKQVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI-YEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTD--WIAIYQRKVEAPFIPKCKGPGDASNFD 266
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004683.1 (pep scaffold:Pmarinus_7.0:GL488517:199:5283:1 gene:ENSPMAG00000004265.1 transcript:ENSPMAT00000004683.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 196.823 bits (499), Expect = 4.177e-60 Identity = 93/178 (52.25%), Postives = 123/178 (69.10%), Query Frame = 1
Query: 463 AFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESA---TSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLG 987
AFQ++ LY++L + GG+LFT L +E E FY+AE++LA+ HLHS GIIYRDLKPEN+LLD+ GH+ LTDFGLSKES +FCGT+EYMAPE++ R+GHT DWWS G L+F+ML+G PF + K+ T+ IL+A L P + S + L++ L KRNP RLG
Sbjct: 1 AFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDESGHIGLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRKGHTHSADWWSFGVLMFEMLTGTLPFQGKDRKE-TMTMILKAKLGMPQFLSGEAQSLLRMLFKRNPGNRLG 177
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Match: mast2 (microtubule associated serine/threonine kinase 2 [Source:ZFIN;Acc:ZDB-GENE-050309-150]) HSP 1 Score: 210.305 bits (534), Expect = 3.149e-58 Identity = 128/339 (37.76%), Postives = 191/339 (56.34%), Query Frame = 1
Query: 223 PHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKAR-IVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNT------------------FCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPM---YFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDS 1173
P KK DFE + +I G YG V+LVR ++ ++ +AMK + K I+RN+ A ER+IL +PF+V + +F+++ +L +V+ Y GG+ T L+ G L + A Y AE LA+ +LH+ GI++RDLKP+N+L+ GHVKLTDFGLSK S T CGT EY+APE++ R+G+ VDWW++G +L++ L G PF ++ ++L +++ + +P DV LI GLL+RNP ERLG E+K H FF + ++WD +L +K E F P L+SE D S FD+ + S DD+
Sbjct: 205 PKKKPCEEDFETIKLISNGAYGAVYLVRH----KETRQRFAMKKINKQNLILRNQIQQAFV--ERDILTFAENPFVVGMFCSFETKRHLCMVMEYVEGGDCATLLKNLGALPVDMAQLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHVKLTDFGLSKIGLMSLTTNLYEEHIEKDTREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEEL-FGQVISDEIVWPEGEDALPSDVQDLITGLLERNPLERLGTGGAF-EVKQHQFF--HSLDWDGLLRQKAE--FVPQLESEEDTSYFDTRSDRYHHLDSEDDT 531
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710]) HSP 1 Score: 282.722 bits (722), Expect = 6.171e-87 Identity = 152/343 (44.31%), Postives = 219/343 (63.85%), Query Frame = 1
Query: 205 CDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSK---ESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVA 1224
D + +K +S+ DF++L VIG+G +GKV VRK +D +K+YA+K L+KA IV ++ + HT +ER +L + PF+V L ++FQS LY+VL + GGELF +L+ EG ++ FYIAE+ A+ LH +IYRDLKPEN+LLD GH+ L DFGL K + T+TFCGT EY+APEIL +G+T VDWW+LG LL++M++G PP+ E+ + +KIL+ PL FP F L+ GLL R+P RLG N +EI++H FF+ DI+W +L + PP+KP +KSE D + FD FT ++PI S D + + F G++Y+
Sbjct: 329 VDYKPSKNKPLSIDDFDLLKVIGKGSFGKVMQVRK----KDTQKIYALKALRKAYIV-SKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVP-VMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGV-NGTDEIRNHPFFK--DISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPIDSVVDEYLSASIQKQFGGWTYIG 662
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609]) HSP 1 Score: 281.952 bits (720), Expect = 1.573e-86 Identity = 147/336 (43.75%), Postives = 216/336 (64.29%), Query Frame = 1
Query: 226 HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSK---ESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVA 1224
+K +S+ DF++L VIG+G +GKV VRK +D +K+YA+K ++K+ IV ++ + HT +ER +L + PF+V L ++FQS LY VL + GGELF +L++EG ++A FY AE+ A+ +LH ++YRDLKPEN+LLD GH+ L DFGL K + T+TFCGT EY+APE+L G+T VDWW+LG LL++ML+G PP+ E ++ +KIL+ PL FP F D L+ GLL R+P RLGY N +EI++H FF + ++W +L + PP+KP + + D S FD FT ++PI S D + + F G++YV
Sbjct: 339 NKPLSIDDFDLLKVIGKGSFGKVMQVRK----KDTQKVYALKAIRKSYIV-SKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKM-YKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGY-NGADEIRNHPFFSQ--LSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPIDSVVDEYLSESVQKQFGGWTYVG 665
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: SCH9 (AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan [Source:SGD;Acc:S000001248]) HSP 1 Score: 283.493 bits (724), Expect = 6.816e-86 Identity = 156/342 (45.61%), Postives = 220/342 (64.33%), Query Frame = 1
Query: 247 DFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEII---RHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS-TNTFCGTIEYMAPEILRRE-GHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPM-YFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTN--------QQPILSPDDSTGTHISEDI---FTGFSYV 1221
DFE+L ++G+G +G+V+ V+K +D +++YAMKVL K IV+ + + AHT ERNIL PF+V L ++FQ+ ++LY+V Y GGELF +L++EG E++A FYIAE+ LA+ HLH I+YRDLKPEN+LLD G++ L DFGLSK TNTFCGT EY+APE+L E G+T +VD+WSLG L+F+M G PF E+++++ +KI +KFP S + +KGLL RNPK RLG +D E+++H FF DI+W+ + +K+ PPFKP L SE D S FD FT QP++ T T +S + F GF++V
Sbjct: 411 DFEVLRLLGKGTFGQVYQVKK----KDTQRIYAMKVLSKKVIVK-KNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKM-YQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFA--DIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMM-----TATPLSPAMQAKFAGFTFV 739
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 256.914 bits (655), Expect = 3.480e-80 Identity = 134/326 (41.10%), Postives = 203/326 (62.27%), Query Frame = 1
Query: 157 YDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLG-YKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKS-EADVSCFD 1128
Y+E++ Q + Q+ K S+ DF+IL +G G +G+V L+R G + YAMKVLKK +VR K HT ER +L I+ HPF++++ FQ +++++ Y GGELF+ L + A FY AE+ LA+ +LHSK IIYRDLKPEN+LLDK GH+K+TDFG +K T T CGT +Y+APE++ + + +DWWS G L+++ML+G PF +S+ T EKIL A L+FP +F+ DV L+ L+ R+ +RLG +N E++K+H +F+ ++ W+ +LSR +E P++P ++ + D S FD
Sbjct: 63 YNEEQYKQFIAQARVTSG-------KYSLQDFQILRTLGTGSFGRVHLIRSRHNG----RYYAMKVLKKEIVVRL-KQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFY-DSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFK--EVVWEKLLSRNIETPYEPPIQQGQGDTSQFD 373
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 254.218 bits (648), Expect = 4.010e-79 Identity = 130/301 (43.19%), Postives = 191/301 (63.46%), Query Frame = 1
Query: 232 KVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLG-YKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKS-EADVSCFD 1128
K S+ DF+IL +G G +G+V L+R G + YA+K LKK IV+ K HT ER +L I+ HPF++++ FQ +++V+ Y GGELF+ L + A FY AE+ LA+ +LHSK IIYRDLKPEN+LLDK GH+K+TDFG +K T T CGT +Y+APE++ + + VDWWS G L+++ML+G PF ++ + T E IL A LKFP +F D L+K L+ R+ ERLG +N E++K+H +F N++ W+ +L+R +E P++P ++ + D S FD
Sbjct: 82 KYSLSDFQILRTLGTGSFGRVHLIRSNHNG----RFYALKTLKKHTIVK-LKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMK-TYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWF--NEVIWEKLLARYIETPYEPPIQQGQGDTSQFD 374
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521]) HSP 1 Score: 420.239 bits (1079), Expect = 9.236e-143 Identity = 215/409 (52.57%), Postives = 284/409 (69.44%), Query Frame = 1
Query: 82 SLTTDNDEKESDKDSMSFGAIREEKYDEKEENQLVTQSIEICDQTVNPH-KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESA---TSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERL-GYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLS----EPWIENKPNR 1281
+L DE SD D G + YDE + +++++ ++TVNP +KV FE+L V+G+GGYGKVFLV+K G ++K++AMKVLKKA I+R++KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG +E+ ACFY++EIS+A+ HLH +GI+YRDLKPEN+LLD GHVKLTDFGL KES + T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF ++ K+ TI+KIL+ L P Y + + I+ LLKR+P+ RL G D IK+H FF+ I W+D+L++KVEPPF+P + E DVS FDS FT Q P+ SPDDS + + +IF GF+YVAP+V ES+ PW P +
Sbjct: 13 ALAAGEDELSSD-DEFDEGQV----YDEPMDGDERMETLQLSEETVNPKDEKVGPESFELLKVLGKGGYGKVFLVKK-NHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKK-TIDKILKGKLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRH--ICWEDLLAKKVEPPFRPSISGEEDVSQFDSKFTRQTPVDSPDDSMLSESASNIFQGFTYVAPSVLESLCRSDNFSPWKVRSPRK 412
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO31895 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWM6]) HSP 1 Score: 319.316 bits (817), Expect = 2.117e-101 Identity = 173/382 (45.29%), Postives = 233/382 (60.99%), Query Frame = 1
Query: 229 KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESA--TSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKN-DVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPD--DSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARF------GHTHVSECKKIV 1341
KK FE+L V+G+G +GKVFLVRKV G D LYAMKVLKKA + +D T ER+IL ++HPF+V+L+YAFQ++ +Y++L + GG+LFT L +E E FY+AE++LA+ HLH GIIYRDLKPEN+LLD GHV LTDFGLSKES T +FCGT+EYMAPE++ R GH+ DWWS G L+F+ML+G PF Q ++ T+ IL+A L P + + + L++ L KRNP RLG + +E+IK H FF + INW+ + R+++PPFKP D FD FT++ P SP S H +F GFSYVAP++ E P P R + + G S C++ V
Sbjct: 2 KKADPSQFELLKVLGQGSFGKVFLVRKVI-GADAGTLYAMKVLKKATL--KVRDRMRTMKERDILVDVQHPFIVRLNYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDASGHVALTDFGLSKESEHDQKTYSFCGTVEYMAPEVVNRRGHSQAADWWSYGVLMFEMLTGSLPF-QGKDRKDTMNMILKAKLGMPQFLTPEAQSLLRQLFKRNPLNRLGAGDLGIEDIKKHPFF--STINWELLYKREIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAVPPSATCH---QLFRGFSYVAPDIVEVETRGPAARAFPIRTTCILDEYEIKEEIGKGAYSSCRRCV 374 HSP 2 Score: 107.842 bits (268), Expect = 1.342e-24 Identity = 70/219 (31.96%), Postives = 117/219 (53.42%), Query Frame = 1
Query: 223 PHKKVSMID-FEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLL-DKCG---HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS 855
P + ++D +EI IG+G Y R+ D K+ YA+K+ +K + KD ++ +L HP +V L A+++ +YIV+ GGEL + + L E +A + ++ I LH +G+++RDLKP N++ D G +++ DFG +K+ + T C T ++APE+L+++G+ D WSLG LL+ MLSG PF+
Sbjct: 346 PIRTTCILDEYEIKEEIGKGAYSSC---RRCVNKADGKE-YAVKIFEKPK-----KDP--SEEMEILLRFGHHPNIVHLRDAYEAGKQVYIVMELMRGGELLDRILKHKCLSEREAGNIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFAKQMRATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPFA 553
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO39163 (Ribosomal protein S6 kinase [Source:UniProtKB/TrEMBL;Acc:A7SAZ2]) HSP 1 Score: 305.449 bits (781), Expect = 2.679e-94 Identity = 162/364 (44.51%), Postives = 231/364 (63.46%), Query Frame = 1
Query: 229 KKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRH-PFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTN-----TFCGTIEYMAPEILR--REGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIE---KILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRK 1287
+KV + +FE+L V+G G YGKVFL RK G + +L+AMKVLKKA IV+ K HT++ER +LE +R PFLV LH+AFQ+++ L++++ Y GGELFT+L + E++ YI EI +A+ HLH GIIYRD+K EN+LLDK GHV LTDFGLSKE A + +FCGTIEYMAPE+++ GH VDWWSLG L++++L+G PF+ + K E +IL P S + + L+ LL+++PK+RLG K E+K+H FF+ D W D+ +++ PFKP ++ E DVS F FT+ P SP T ++ +F G+S+VAP++ + E +P +RK
Sbjct: 9 EKVGIENFELLRVLGTGAYGKVFLARK-RGGHHDGRLFAMKVLKKATIVQKAKTAEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRLYIGEIVVALDHLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFAAPNSGERAYSFCGTIEYMAPEVVKGGSRGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQSEISKRILHNNPPMPHDLSAEAIDLLHKLLQKDPKKRLGAKG-AHELKAHPFFKAFD--WADLAEKRIPAPFKPRIRDELDVSNFSEEFTDMAPTYSPAAVPKT--ADRVFRGYSFVAPSI---IFGENEFNQQPVQRK 363 HSP 2 Score: 112.464 bits (280), Expect = 6.216e-26 Identity = 77/274 (28.10%), Postives = 134/274 (48.91%), Query Frame = 1
Query: 265 VIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLL---DKCGHVKLTDFGLS--KESATSTNTFCGTIEYMAPEILRR----EGHTFVVDWWSLGTLLFDMLSGGPPFSQ-----ESSKQLTIEKILRAPLKFP----MYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQ 1032
V+G G + + G++ YA+K++ + HT+ +++ HP +V L+ +Q + + Y+V+ GGEL + ++ E+ A + +I A+ +H +G+++RDLKPEN+L + +K+ DFG + K A T C T+ Y APE+L + G+ D WSLG +L+ MLSG PF +SS +++I + ++F S LI+GLL +P +RL V+E+ H + +
Sbjct: 401 VLGDGSFSTCRRCVHLRSGQE----YAVKIISRR--------CDHTREVQSLKMCHGHPNIVTLYDVYQDEFHTYLVMELLAGGELLERIRKKKMFTESAASVIMRKIVSAVEFMHQRGVVHRDLKPENLLFVDNSEDAEIKIVDFGFACVKPEAQQLQTPCFTLSYAAPEVLDQTVSNSGYDESCDLWSLGVILYTMLSGQVPFQSSGSWYKSSTGFVMQRITQGDVRFDGQQWQSISPQAKDLIQGLLTVDPSQRL----TVQEVLRHDWLR 658
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2]) HSP 1 Score: 285.804 bits (730), Expect = 1.224e-90 Identity = 170/424 (40.09%), Postives = 249/424 (58.73%), Query Frame = 1
Query: 4 ESLNIFTK*FLLLQMHGSLEYINTYDSLTTDNDEKESDKDSMSFGAIREEKYDEKEENQLVTQSIEICD--QTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNIL-EIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPI-----LSPDD---STGTHISEDIFTGFSYVAPN 1230
E LN F +L G+L++ + + L+ DN + + DE E+ +E D ++ NP K S DF L VIG+G +GKVFL + + E K YA+KVL K+ I R + H +ERN+L + + HPFLV LHY+FQ++ LY VL Y GGELF +L+RE E++A FY AEI+ AIG+LH IIYRDLKPEN+LLD GH+ LTDFGL KE + +T+TFCGT EY+APE+LR++ + VDWW LG +L++M+ G PPF + ++ + IL PL+ S +++GLL+++ +RLG + D E+I++H FF+ INW +++R +EPP+ P++ + D+ FD F ++P+ S D S +D F GF+YVAP+
Sbjct: 7 EGLNDFI--VKILTHPGALDHPDVREFLSLDNPKNA-------------QANDEDEQPGSDDADVEKIDLGESNNPKAKPS--DFLFLKVIGKGSFGKVFLSKN----KQEDKFYAIKVLNKSAI-RKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEM-YDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRS--INWQQLVARGIEPPYNPNVSGQLDLKHFDPEFV-REPVPGSVGKSADSNFVSASVDDPDDAFVGFTYVAPS 404
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Match: EDO44938 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU22]) HSP 1 Score: 268.085 bits (684), Expect = 4.400e-82 Identity = 144/346 (41.62%), Postives = 209/346 (60.40%), Query Frame = 1
Query: 235 VSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILE-IIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFS--------QESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY--KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTH-ISEDIFTGFSYVAP 1227
+S+ DF ++ VIGRG Y KV LV + K++YAMKV+KK +V +++D ++E+++ E HPFLV LH FQ+ S L+ V+ Y GG+L +++R+ L E+ A FY AEI A+ LH KG+IYRDLK +NVLLD GH+KLTD+G+ KE T+TFCGT Y+APEILR E + F VDWW+LG LL++ML+G PF ++++ + IL P++ P S+ ++KG L +NP ERLG + +I SH FF+ ++W+ + +R+V PPFKP + + FD FTN+ +PDD I + F GF Y+ P
Sbjct: 217 ISVNDFNLIRVIGRGSYAKVMLVEL----KKTKRIYAMKVVKK-ELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTSSRLFFVIEYVSGGDLMYHMQRQRRLPEDHARFYSAEICCALNFLHEKGVIYRDLKLDNVLLDSDGHIKLTDYGMCKEGIRPGDVTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDIVGSADNPDQNTEDYLFQVILEKPIRIPRSLSVKAASILKGYLNKNPTERLGCHPQTGFADITSHAFFRT--VSWEQLEARQVTPPFKPRQEDPYGLENFDPQFTNEDVQFTPDDPKMLETIDQTEFEGFEYINP 555
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1a (ribosomal protein S6 kinase beta-1 [Source:NCBI gene;Acc:101174287]) HSP 1 Score: 426.017 bits (1094), Expect = 1.198e-143 Identity = 224/401 (55.86%), Postives = 275/401 (68.58%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERL-GYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSK 1440
FE+L V+G+GGYGKVF VRKV+ G K+YAMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RL G D E++ H FF+ INWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E+V + E K R F T +S K D S N T C H ++GV +
Sbjct: 39 FELLKVLGKGGYGKVFQVRKVS-GASSGKIYAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLSLPPYLTQEARDLLKKLLKRSASSRLGGGPGDAAEVQVHPFFRH--INWDDLLARKVEPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENVKEKFSFEPK-LRSPRKFPGSPRTLLSPLKFSGGDSWLRGPLPSGNPSTVCPGSGEHPMEVSGVEQ 434
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1a (ribosomal protein S6 kinase beta-1 [Source:NCBI gene;Acc:101174287]) HSP 1 Score: 426.017 bits (1094), Expect = 1.738e-143 Identity = 224/401 (55.86%), Postives = 275/401 (68.58%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERL-GYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSK 1440
FE+L V+G+GGYGKVF VRKV+ G K+YAMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RL G D E++ H FF+ INWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E+V + E K R F T +S K D S N T C H ++GV +
Sbjct: 49 FELLKVLGKGGYGKVFQVRKVS-GASSGKIYAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLSLPPYLTQEARDLLKKLLKRSASSRLGGGPGDAAEVQVHPFFRH--INWDDLLARKVEPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENVKEKFSFEPK-LRSPRKFPGSPRTLLSPLKFSGGDSWLRGPLPSGNPSTVCPGSGEHPMEVSGVEQ 444
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: RPS6KB2 (ribosomal protein S6 kinase beta-2 [Source:NCBI gene;Acc:101163545]) HSP 1 Score: 424.091 bits (1089), Expect = 3.672e-143 Identity = 209/364 (57.42%), Postives = 269/364 (73.90%), Query Frame = 1
Query: 169 EENQLVTQSIEICDQTVN-PHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
E + T+ +E+ + VN ++V FE+LTV+G+G YGKVF VRKV G K++AMKVLKKA+IVRN KDTAHT++ER ILE +RHPF+V L YAFQ+ LY++L GGELF LE+EG ME+ ACFY+ EI+LA+GHLHS GIIYRDLKPEN++L+ GH+KLTDFGL KES + T+TFCGTIEYMAPEIL R GH VDWWSLG L++DM++G PPF+ E+ K+ TI+KIL+ L P Y ++D LIK LLK+NP +RLG K D +I+ H FF++ INWDD+L+++VEPP+KP L SE DVS FD+ FT Q P+ SPDDS +H +E F GF+YVAP+V ES+
Sbjct: 28 EPENVQTEEVELTSEIVNRDSERVGPDCFELLTVLGKGAYGKVFQVRKVQ-GLQIGKIFAMKVLKKAKIVRNAKDTAHTRAEREILETVRHPFIVDLLYAFQTGGKLYLILECLSGGELFMQLEKEGIFMEDTACFYLGEITLALGHLHSNGIIYRDLKPENIMLNHQGHIKLTDFGLCKESIHDGSVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDMMTGSPPFTAENRKK-TIDKILKCKLNLPPYLTIDARELIKKLLKKNPAQRLGSGKADAADIQKHSFFKQ--INWDDLLNKRVEPPYKPQLHSEEDVSQFDTRFTRQTPVDSPDDSRLSHSAELAFAGFTYVAPSVLESL 387
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: RPS6KB2 (ribosomal protein S6 kinase beta-2 [Source:NCBI gene;Acc:101163545]) HSP 1 Score: 423.705 bits (1088), Expect = 4.707e-143 Identity = 208/358 (58.10%), Postives = 267/358 (74.58%), Query Frame = 1
Query: 187 TQSIEICDQTVN-PHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESV 1245
T+ +E+ + VN ++V FE+LTV+G+G YGKVF VRKV G K++AMKVLKKA+IVRN KDTAHT++ER ILE +RHPF+V L YAFQ+ LY++L GGELF LE+EG ME+ ACFY+ EI+LA+GHLHS GIIYRDLKPEN++L+ GH+KLTDFGL KES + T+TFCGTIEYMAPEIL R GH VDWWSLG L++DM++G PPF+ E+ K+ TI+KIL+ L P Y ++D LIK LLK+NP +RLG K D +I+ H FF++ INWDD+L+++VEPP+KP L SE DVS FD+ FT Q P+ SPDDS +H +E F GF+YVAP+V ES+
Sbjct: 33 TEEVELTSEIVNRDSERVGPDCFELLTVLGKGAYGKVFQVRKVQ-GLQIGKIFAMKVLKKAKIVRNAKDTAHTRAEREILETVRHPFIVDLLYAFQTGGKLYLILECLSGGELFMQLEKEGIFMEDTACFYLGEITLALGHLHSNGIIYRDLKPENIMLNHQGHIKLTDFGLCKESIHDGSVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDMMTGSPPFTAENRKK-TIDKILKCKLNLPPYLTIDARELIKKLLKKNPAQRLGSGKADAADIQKHSFFKQ--INWDDLLNKRVEPPYKPQLHSEEDVSQFDTRFTRQTPVDSPDDSRLSHSAELAFAGFTYVAPSVLESL 386
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Match: rps6kb1a (ribosomal protein S6 kinase beta-1 [Source:NCBI gene;Acc:101174287]) HSP 1 Score: 425.246 bits (1092), Expect = 5.030e-143 Identity = 224/401 (55.86%), Postives = 275/401 (68.58%), Query Frame = 1
Query: 250 FEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES---ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERL-GYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSK 1440
FE+L V+G+GGYGKVF VRKV+ G K+YAMKVLKKA IVRN KDTAHTK+ERNILE ++HPF+V L YAFQ+ LY++L Y GGELF LEREG ME+ ACFY+AEIS+A+GHLH KGIIYRDLKPEN++L+ GHVKLTDFGL KES T T+TFCGTIEYMAPEIL R GH VDWWSLG L++DML+G PPF+ E+ K+ TI+KIL+ L P Y + + L+K LLKR+ RL G D E++ H FF+ INWDD+L+RKVEPPFKP L+S DVS FDS FT+Q P+ SPDDST + + +F GF+YVAP+V E+V + E K R F T +S K D S N T C H ++GV +
Sbjct: 66 FELLKVLGKGGYGKVFQVRKVS-GASSGKIYAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK-TIDKILKCKLSLPPYLTQEARDLLKKLLKRSASSRLGGGPGDAAEVQVHPFFRH--INWDDLLARKVEPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDSTLSESANQVFLGFTYVAPSVLENVKEKFSFEPK-LRSPRKFPGSPRTLLSPLKFSGGDSWLRGPLPSGNPSTVCPGSGEHPMEVSGVEQ 461
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000046977.1 (SMESG000046977.1) HSP 1 Score: 785.408 bits (2027), Expect = 0.000e+0 Identity = 378/378 (100.00%), Postives = 378/378 (100.00%), Query Frame = 1
Query: 553 MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSKSYKSPSVIEKHNGVIKPSSSDLALASLVPANGKGSVKTEPIGNLKYNKKKSFDFGQPKINGTLNGAGNIFTNDTSKNKCSIM 1686
MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSKSYKSPSVIEKHNGVIKPSSSDLALASLVPANGKGSVKTEPIGNLKYNKKKSFDFGQPKINGTLNGAGNIFTNDTSKNKCSIM
Sbjct: 1 MENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEPWIENKPNRRKTLFARFGHTHVSECKKIVEDDVPGAQQISSNNQTKCVPISNHSNAINGVSKSYKSPSVIEKHNGVIKPSSSDLALASLVPANGKGSVKTEPIGNLKYNKKKSFDFGQPKINGTLNGAGNIFTNDTSKNKCSIM 378
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000004478.1 (SMESG000004478.1) HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0 Identity = 293/406 (72.17%), Postives = 337/406 (83.00%), Query Frame = 1
Query: 46 MHGSLEYINTYDSLTT-DNDE-KESDKDSMSFGAIREEKYDEKEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAESVLSEP 1257
M SL+YI T D + + DND + S++D +S + ++EE+ + +S+EIC VNP K+SM DF++L VIGRGGYGKVFLV+K + G DE KLYAMKVLKKARI+RNEKDTAHTKSERNILE+IRHPFLVKLHYAFQ+QSNLYIVLTYC GGELFTYLEREGTLMENQACFY+AEISLAIGHLH GIIYRDLKPENVLLDK GHVKLTDFGLSKES + TNTFCGTIEYMAPEIL+R GH VDWWSLGTLLFDMLSGGPPFSQE KQ TI KIL + + +P YFS +V+ LI+GLLKRNPKERLG KNDVE+IK+H FF+ +DINW D+ R+++PPFKP+LKSE DVSCFDSTFT QQPI++PDD G HI D+F GFSYVAPNVA SVL+EP
Sbjct: 1 MESSLDYIVTEDDIVSKDNDFIRLSERDELSIQQFIQNGPLKREEDDDI-ESVEICQSVVNPGVKISMEDFKVLNVIGRGGYGKVFLVQKSSSGHDENKLYAMKVLKKARIIRNEKDTAHTKSERNILEMIRHPFLVKLHYAFQNQSNLYIVLTYCSGGELFTYLEREGTLMENQACFYVAEISLAIGHLHKTGIIYRDLKPENVLLDKKGHVKLTDFGLSKESVSLTNTFCGTIEYMAPEILKRGGHGKEVDWWSLGTLLFDMLSGGPPFSQECDKQETITKILHSTIAYPKYFSSEVVRLIQGLLKRNPKERLGCKNDVEDIKNHEFFKTHDINWSDVYHRRMDPPFKPELKSEMDVSCFDSTFTGQQPIMTPDDCNGAHILPDLFQGFSYVAPNVASSVLNEP 405
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000068122.1 (SMESG000068122.1) HSP 1 Score: 360.918 bits (925), Expect = 4.760e-119 Identity = 187/361 (51.80%), Postives = 254/361 (70.36%), Query Frame = 1
Query: 166 KEENQLVTQSIEICDQTVNP-HKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEK-DTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESATS--TNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERL-GYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNV 1233
K+E ++S++IC++TVNP KV+ DF++L +G+GGYG+VFL +KV G + +AMKV+KKAR++ N+K DT + +ERNILE + HPFLVKL++AFQ+ +L++VL Y GGELF LER+ TL E++A FY+AE +LA+GHLHS G+IYRDLK ENV+LD+ GHVKLTDFGLSKE T++FCGT+EYMAPEIL+R GH VDWWS+G LL+DML G PF + Q+ I+K+ A LK P + + L+K LL +NPK RL G + DVEEIK H FF+ INWD L+R+++PPF P+L S DVS FD ++ ++SP + ++ F FSYV+P V
Sbjct: 40 KDEYDSTSKSVDICEETVNPPGVKVTSHDFDLLKKLGKGGYGQVFLAKKVN-GAMAGEYFAMKVVKKARLITNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFLVLEYLAGGELFMQLERQHTLTEDEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGNSPFVGGNRSQV-IQKVTNAKLKIPRFLTDSGKHLLKNLLNKNPKARLGGGEKDVEEIKRHFFFRS--INWDKALARELKPPFIPELSSRDDVSLFDKNIVSEPCMISPTTTDDSNCY--WFENFSYVSPQV 394
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000059433.1 (SMESG000059433.1) HSP 1 Score: 348.977 bits (894), Expect = 8.164e-111 Identity = 186/387 (48.06%), Postives = 250/387 (64.60%), Query Frame = 1
Query: 121 DSMSFGAIREEKYDE--------KEENQLVTQSIEICDQTVNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKES-----ATSTNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGY-KNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPILSPDDSTGTHISEDIFTGFSYVAPNVAE 1239
DS + E + DE +EE ++++ D+ K+ FE+L V+G+G +GKVFLVRKV+ + + LYAMKVLKKA + +D TK ER+IL IRHPF+V LHYAFQ++ +Y++L + GG+LF+ L +E E+ FY+AE++LA+ HLHS GI+YRDLKPEN+LLD+ GH+KLTDFGLSKES A T +FCGT+EYMAPE++ R+GH DWWS G L+F+ML+G PF Q SS++ T+ IL+A L P + S + L++ L KRNP R+G+ +EEIKS FFQ INW D+L+RKV PPFKP D SCFDS FT++ P SP +E IF GFSYVAP+V +
Sbjct: 8 DSFHISNLNEVEVDEEFSDNAFSQEEEATEVNAVDLVDE------KLDSSHFELLRVLGQGSFGKVFLVRKVSEPQ-QGILYAMKVLKKASL--KVQDRKRTKMERDILAAIRHPFIVTLHYAFQNEGKVYLILEFLKGGDLFSRLSKEFMFTEDDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEDGHIKLTDFGLSKESIYNDDANRTFSFCGTVEYMAPEVVNRKGHGTAADWWSFGVLMFEMLTGQLPF-QGSSRKETMTMILKAKLSMPQFLSSEAQTLLRVLFKRNPSNRIGFGPKGIEEIKSQPFFQL--INWKDLLNRKVTPPFKPKATCLDDTSCFDSQFTSKTPKESPCQPASATANE-IFRGFSYVAPDVLQ 381 HSP 2 Score: 100.523 bits (249), Expect = 7.222e-22 Identity = 62/211 (29.38%), Postives = 106/211 (50.24%), Query Frame = 1
Query: 268 IGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNILEIIR-------HPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCG----HVKLTDFGLSKESATSTN---TFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQ 858
IG+G + + T G + YA+KV+ + R+++E + HP +VKL + Q+ + +++ Y GGEL T + + E +A + ++ + +LH+ +++RDLKP N+L K ++ + DFG +K+ T C T ++APE+L+++G+ D WSLG LLF MLSG PF+Q
Sbjct: 417 IGKGSFSVCYRAVHKTTGVN----YAIKVIDGTK--------------RDVIEEVEILFRFGAHPHIVKLKEVYVQQNTVSLIMEYLEGGELLTNILSQKYFSEKEASKILYVLTETVHYLHTNLVVHRDLKPSNILYSKKDTNPENLVICDFGFAKQQRAENGLLMTPCYTANFVAPEVLKKQGYDKASDVWSLGVLLFIMLSGKTPFTQ 609
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Match: SMESG000022857.1 (SMESG000022857.1) HSP 1 Score: 286.96 bits (733), Expect = 6.303e-90 Identity = 162/406 (39.90%), Postives = 246/406 (60.59%), Query Frame = 1
Query: 61 EYINTYDSLTTDNDEKESDKDSMSFGAIREEKYDEKEE--NQLVTQSIEICDQT---VNPHKKVSMIDFEILTVIGRGGYGKVFLVRKVTPGEDEKKLYAMKVLKKARIVRNEKDTAHTKSERNIL-EIIRHPFLVKLHYAFQSQSNLYIVLTYCPGGELFTYLEREGTLMENQACFYIAEISLAIGHLHSKGIIYRDLKPENVLLDKCGHVKLTDFGLSKESAT---STNTFCGTIEYMAPEILRREGHTFVVDWWSLGTLLFDMLSGGPPFSQESSKQLTIEKILRAPLKFPMYFSLDVMGLIKGLLKRNPKERLGYKNDVEEIKSHIFFQKNDINWDDILSRKVEPPFKPDLKSEADVSCFDSTFTNQQPI--------LSPDDSTGTHISEDIFTGFSYVAP 1227
E +N + + D+ + K+ F I + YD +EE + V ++ D V+ +K DF+ + IG+G +GKVFL R+ + G ++A+KVL K I + + H SERNIL + +RHPFL +L+++FQ++ LY L Y GGELF +L++E + + +A FY AEI ++G+LHSK IIYRDLKPEN+LLD GH+ LTDFGL KE +T+TFCGT EY+APE++++E + VDWWS G+++++ML G PPF + + Q+ ++IL +PL + ++ L+++NPKERLGYKND +EIK H FF + I+W +++++V+PPF P + S AD+ D F +++PI L+ +D F GFSYV P
Sbjct: 75 EGLNEFVTKLLDSPDIWELKEVRDFFGIDRQNYDHEEEVSQENVDENYPHEDNINLGVSENKLAKPADFDFIKTIGKGSFGKVFLARRKSDG----AVFAVKVLYKENI-KKRNEVKHIMSERNILVQNLRHPFLCRLYFSFQTKRKLYFFLDYVNGGELFFHLQKERSFSQKRAQFYAAEIGSSLGYLHSKNIIYRDLKPENILLDAQGHIILTDFGLCKEGIEREGTTSTFCGTPEYLAPEVIKKEPYDRSVDWWSFGSVIYEMLFGLPPFYSQDTHQM-YQRILNSPLPLRGNCPSVISDILVKLIRKNPKERLGYKNDFDEIKVHPFFSQ--IDWVALVNKQVKPPFVPQVSSNADIRNIDPEF-HKEPISGSIPNSQLNRRTQLSVEDVDDSFVGFSYVPP 471 The following BLAST results are available for this feature:
BLAST of Ribosomal protein S6 kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Ribosomal protein S6 kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30026874 ID=SMED30026874|Name=Ribosomal protein S6 kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1827bpback to top protein sequence of SMED30026874-orf-1 >SMED30026874-orf-1 ID=SMED30026874-orf-1|Name=SMED30026874-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=548bp MHGSLEYINTYDSLTTDNDEKESDKDSMSFGAIREEKYDEKEENQLVTQSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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