Gamma-glutamylcyclotransferase

Overview
NameGamma-glutamylcyclotransferase
Smed IDSMED30026774
Length (bp)945
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Gamma-glutamylcyclotransferase (SMED30026774) t-SNE clustered cells

Violin plots show distribution of expression levels for Gamma-glutamylcyclotransferase (SMED30026774) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Gamma-glutamylcyclotransferase (SMED30026774) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Gamma-glutamylcyclotransferase (SMED30026774) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30026774

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30026774h1SMcG0018271 dd_Smed_v4_2439_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30026774h1SMcG0018271 dd_Smed_v4_2439_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30026774h1SMcG0018271 dd_Smed_v4_2439_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30026774h1SMcG0018271 dd_Smed_v4_2439_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30026774h1SMcG0018271 dd_Smed_v4_2439_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30026774h1SMcG0018271 Contig51293newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30026774h1SMcG0018271 Contig51293uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Human
Match: CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680])

HSP 1 Score: 150.984 bits (380), Expect = 7.164e-44
Identity = 78/193 (40.41%), Postives = 114/193 (59.07%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKV 767
            ALW FGY SL+W+P F+YS+  VG ++GY RRF+QG T HRG+ + PGRV T+++D     WGVAY+V  E ++ KAL +L  RE + GGY   +VTF+P +    P++   YVA P+N  YLG     +A A QI   +G  G N EY+ ++ +FM+    Q      D++L  +   +      F P+E+ 
Sbjct:   32 ALWIFGYGSLVWRPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGE-QVSKALKYLNVREAVLGGYDTKEVTFYPQDAPDQPLKALAYVATPQNPGYLGPAPE-EAIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQ----DEHLAAIVDAVGTMLPCFCPTEQA 218
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Human
Match: CHAC2 (ChaC cation transport regulator homolog 2 [Source:HGNC Symbol;Acc:HGNC:32363])

HSP 1 Score: 132.88 bits (333), Expect = 2.506e-37
Identity = 70/186 (37.63%), Postives = 108/186 (58.06%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNG 746
            +W FGY SLIWK  F Y +++VG I  Y RRF+QG+T HRG P  PGRV T+++D +  VWGVAY +   ++E +KA +   E+    GGY    V F+P +    P  + +Y+   +N  YLG    ++  A QI  A G  G+N+EY+ ++   ++N + +    + D++LF L KL+ +   G
Sbjct:    1 MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPAGCVWGVAYRLPVGKEEEVKAYLDFREK----GGYRTTTVIFYPKDPTTKPFSVLLYIGTCDNPDYLGP-APLEDIAEQIFNAAGPSGRNTEYLFELANSIRNLVPE----EADEHLFALEKLVKERLEG 177
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Human
Match: CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680])

HSP 1 Score: 98.2117 bits (243), Expect = 3.368e-24
Identity = 60/193 (31.09%), Postives = 87/193 (45.08%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKV 767
            ALW FGY SL+W+P F+YS+  VG ++GY RRF+QG T HRG+ + PGRV T+++D     WGVAY+V  E                                              +N  YLG     +A A QI   +G  G N EY+ ++ +FM+    Q      D++L  +   +      F P+E+ 
Sbjct:   32 ALWIFGYGSLVWRPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGE----------------------------------------------QNPGYLGPAPE-EAIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQ----DEHLAAIVDAVGTMLPCFCPTEQA 173
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Celegans
Match: F22F7.7 (Gamma-glutamylcyclotransferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3ARZ2])

HSP 1 Score: 104.76 bits (260), Expect = 5.957e-27
Identity = 67/181 (37.02%), Postives = 91/181 (50.28%), Query Frame = 3 
Query:  183 SMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTF---FPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFEL 716
            S +LW FGY SLIW PGF++S        G+ RR YQG T HRG  + PGRVAT+I++ +S   GV + V  +  I  A+ +L +RE    GY F  V        +   T +     VAD +N  YLG    I   A +I  A+G  G N EYV  + E ++           D +LF+L
Sbjct:   10 SQSLWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEETNSYTNGVVFRVDGKSAIATAVKYLEQRE-CDNGYAFRMVPVQIRSAAHRRPTVVMALTCVADQQNELYLGPDDLIK-MAREIVTAKGCAGPNCEYVLNLAENLRKLFPNDE----DDHLFQL 184
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Celegans
Match: F22F7.7 (Gamma-glutamylcyclotransferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3ARZ2])

HSP 1 Score: 104.76 bits (260), Expect = 5.957e-27
Identity = 67/181 (37.02%), Postives = 91/181 (50.28%), Query Frame = 3 
Query:  183 SMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTF---FPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFEL 716
            S +LW FGY SLIW PGF++S        G+ RR YQG T HRG  + PGRVAT+I++ +S   GV + V  +  I  A+ +L +RE    GY F  V        +   T +     VAD +N  YLG    I   A +I  A+G  G N EYV  + E ++           D +LF+L
Sbjct:   10 SQSLWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEETNSYTNGVVFRVDGKSAIATAVKYLEQRE-CDNGYAFRMVPVQIRSAAHRRPTVVMALTCVADQQNELYLGPDDLIK-MAREIVTAKGCAGPNCEYVLNLAENLRKLFPNDE----DDHLFQL 184
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Celegans
Match: F22F7.7 (Gamma-glutamylcyclotransferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3ARZ2])

HSP 1 Score: 105.145 bits (261), Expect = 1.075e-26
Identity = 67/181 (37.02%), Postives = 91/181 (50.28%), Query Frame = 3 
Query:  183 SMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTF---FPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFEL 716
            S +LW FGY SLIW PGF++S        G+ RR YQG T HRG  + PGRVAT+I++ +S   GV + V  +  I  A+ +L +RE    GY F  V        +   T +     VAD +N  YLG    I   A +I  A+G  G N EYV  + E ++           D +LF+L
Sbjct:   47 SQSLWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEETNSYTNGVVFRVDGKSAIATAVKYLEQRE-CDNGYAFRMVPVQIRSAAHRRPTVVMALTCVADQQNELYLGPDDLIK-MAREIVTAKGCAGPNCEYVLNLAENLRKLFPNDE----DDHLFQL 221
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Celegans
Match: F22F7.7 (Gamma-glutamylcyclotransferase [Source:UniProtKB/TrEMBL;Acc:A0A0K3ARZ2])

HSP 1 Score: 105.145 bits (261), Expect = 1.075e-26
Identity = 67/181 (37.02%), Postives = 91/181 (50.28%), Query Frame = 3 
Query:  183 SMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTF---FPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFEL 716
            S +LW FGY SLIW PGF++S        G+ RR YQG T HRG  + PGRVAT+I++ +S   GV + V  +  I  A+ +L +RE    GY F  V        +   T +     VAD +N  YLG    I   A +I  A+G  G N EYV  + E ++           D +LF+L
Sbjct:   47 SQSLWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEETNSYTNGVVFRVDGKSAIATAVKYLEQRE-CDNGYAFRMVPVQIRSAAHRRPTVVMALTCVADQQNELYLGPDDLIK-MAREIVTAKGCAGPNCEYVLNLAENLRKLFPNDE----DDHLFQL 221
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Fly
Match: CG10365 (gene:FBgn0039109 transcript:FBtr0084447)

HSP 1 Score: 142.895 bits (359), Expect = 3.069e-40
Identity = 75/171 (43.86%), Postives = 100/171 (58.48%), Query Frame = 3 
Query:  177 PKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFP-LNNLKTP-----IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEI 671
            P   A W FGY SL W PGF+Y+  I G I+GY RRF+QG  THRG  E PGRVAT+++D   + WG AY +T       AL +L +RE   GGY      FFP + +  TP     +E+ VYVA PEN+ +LG+   ++  A QI   +G  G N+EY+ ++  FM  EI
Sbjct:   52 PSDPACWVFGYGSLCWHPGFNYTKCITGYIRGYVRRFWQGNVTHRGCEEKPGRVATLVEDKEGITWGCAYRITGS----TALDYLKQRECTLGGYATIDTKFFPRVASQDTPFSGEAVEVLVYVATPENIYWLGD-DPVEEIAQQIVSCRGPSGHNAEYLLRLALFMHEEI 217
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Fly
Match: CG10365 (gene:FBgn0039109 transcript:FBtr0084448)

HSP 1 Score: 142.895 bits (359), Expect = 3.069e-40
Identity = 75/171 (43.86%), Postives = 100/171 (58.48%), Query Frame = 3 
Query:  177 PKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFP-LNNLKTP-----IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEI 671
            P   A W FGY SL W PGF+Y+  I G I+GY RRF+QG  THRG  E PGRVAT+++D   + WG AY +T       AL +L +RE   GGY      FFP + +  TP     +E+ VYVA PEN+ +LG+   ++  A QI   +G  G N+EY+ ++  FM  EI
Sbjct:   52 PSDPACWVFGYGSLCWHPGFNYTKCITGYIRGYVRRFWQGNVTHRGCEEKPGRVATLVEDKEGITWGCAYRITGS----TALDYLKQRECTLGGYATIDTKFFPRVASQDTPFSGEAVEVLVYVATPENIYWLGD-DPVEEIAQQIVSCRGPSGHNAEYLLRLALFMHEEI 217
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Fly
Match: CG10365 (gene:FBgn0039109 transcript:FBtr0084446)

HSP 1 Score: 142.895 bits (359), Expect = 3.069e-40
Identity = 75/171 (43.86%), Postives = 100/171 (58.48%), Query Frame = 3 
Query:  177 PKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFP-LNNLKTP-----IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEI 671
            P   A W FGY SL W PGF+Y+  I G I+GY RRF+QG  THRG  E PGRVAT+++D   + WG AY +T       AL +L +RE   GGY      FFP + +  TP     +E+ VYVA PEN+ +LG+   ++  A QI   +G  G N+EY+ ++  FM  EI
Sbjct:   52 PSDPACWVFGYGSLCWHPGFNYTKCITGYIRGYVRRFWQGNVTHRGCEEKPGRVATLVEDKEGITWGCAYRITGS----TALDYLKQRECTLGGYATIDTKFFPRVASQDTPFSGEAVEVLVYVATPENIYWLGD-DPVEEIAQQIVSCRGPSGHNAEYLLRLALFMHEEI 217
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Fly
Match: CG10365 (gene:FBgn0039109 transcript:FBtr0084449)

HSP 1 Score: 142.895 bits (359), Expect = 3.069e-40
Identity = 75/171 (43.86%), Postives = 100/171 (58.48%), Query Frame = 3 
Query:  177 PKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFP-LNNLKTP-----IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEI 671
            P   A W FGY SL W PGF+Y+  I G I+GY RRF+QG  THRG  E PGRVAT+++D   + WG AY +T       AL +L +RE   GGY      FFP + +  TP     +E+ VYVA PEN+ +LG+   ++  A QI   +G  G N+EY+ ++  FM  EI
Sbjct:   52 PSDPACWVFGYGSLCWHPGFNYTKCITGYIRGYVRRFWQGNVTHRGCEEKPGRVATLVEDKEGITWGCAYRITGS----TALDYLKQRECTLGGYATIDTKFFPRVASQDTPFSGEAVEVLVYVATPENIYWLGD-DPVEEIAQQIVSCRGPSGHNAEYLLRLALFMHEEI 217
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Fly
Match: CG2540 (gene:FBgn0030411 transcript:FBtr0073675)

HSP 1 Score: 102.834 bits (255), Expect = 5.381e-25
Identity = 70/192 (36.46%), Postives = 98/192 (51.04%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSS--VVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTF--FPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEP 755
            +W FGY SL+WK  F Y +R  G + G+KRRFYQ +  HRG PE PGRV T++  D +   V+GVAY +    +    L HL  RE    GY    + F  +P +  + PI++ +YVA   N  Y G+   +   A QI  + G  G N EY+  +   M    DQ      D++L EL   + +Y    EP
Sbjct:   74 VWIFGYGSLVWKTDFPYIDRRRGFVWGFKRRFYQHSIDHRGIPERPGRVVTLLPGDPAQDRVYGVAYRIAASQKG-AVLDHLDYRE--KNGYERCSLEFHEYPTDGAE-PIQVIMYVATQANDSYAGDVWQVPCIARQIFSSAGPSGPNREYLFNLAAAM----DQLFPGAVDEHLEELVACVKRYIVEDEP 257
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Zebrafish
Match: chac1 (ChaC, cation transport regulator homolog 1 (E. coli) [Source:NCBI gene;Acc:563855])

HSP 1 Score: 145.976 bits (367), Expect = 1.932e-42
Identity = 77/167 (46.11%), Postives = 103/167 (61.68%), Query Frame = 3 
Query:  162 ETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMK 662
            + +V  KS +LW FGY SL+WKP F Y    VG IKGYKRRF+ G   HRG  E PGRV T+I++D    WGVA+EVT   ++ ++L +L  RE + GGY    V FFP    + P++  VY+A P+N  YLG   S +  A QIA  +G  G N EY+ ++ EFM+
Sbjct:    4 QDIVAGKS-SLWIFGYGSLVWKPDFKYKRSKVGYIKGYKRRFWHGDNFHRGDDEMPGRVVTLIEEDDVCTWGVAFEVTGS-QMEESLKYLNVREAVRGGYLTRAVDFFPRGTNQPPVQALVYIATPDNPIYLGP-ASTEEIASQIAVCKGNSGHNIEYLLRLAEFMR 167
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Zebrafish
Match: chac2 (ChaC, cation transport regulator homolog 2 (E. coli) [Source:NCBI gene;Acc:557614])

HSP 1 Score: 127.872 bits (320), Expect = 1.318e-35
Identity = 67/186 (36.02%), Postives = 110/186 (59.14%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPI-EMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQN 743
            +W FGY SLIWK  F Y ++ VG +KG+ RRF+QG+T HRG P  PGRV T+I+D    VWGVAY++ + +++ +K  +   E+    GGY    VTF P +  + P+ +  +Y+   +N  YLG    ++  A QI K+ G  G+N++Y+ ++ + ++  + +      D +LF L +L+ + Q 
Sbjct:    1 MWVFGYGSLIWKVDFPYEDKRVGFVKGFSRRFWQGSTDHRGVPGKPGRVVTLIEDPEGCVWGVAYKLPSGQEQEVKEYLDYREK----GGYGVITVTFHPKDEQQQPMQDTLLYIGSCDNPNYLGP-APLETIAQQIVKSVGPSGKNTDYLFELADALRQLVPE----DLDDHLFSLERLVKQLQE 177
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Xenopus
Match: sgcg (sarcoglycan gamma [Source:Xenbase;Acc:XB-GENE-956423])

HSP 1 Score: 137.502 bits (345), Expect = 9.595e-39
Identity = 73/181 (40.33%), Postives = 106/181 (58.56%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLN-NLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLI 728
            +LW FGY SL+WKP F +++  VG + GY R+F+QG T HRG+P+ PGRV T+ +D S   WG+AYEV  + +I  +L HL  RE + GGY    V F+P +   +  +   VY+A P+N +YLG   S +  A QI    G  G N EY+ ++ EFM N          D++LF + + +
Sbjct:   17 SLWIFGYGSLVWKPNFEFTSSKVGFVPGYSRKFWQGDTFHRGSPQMPGRVVTLQEDYSECTWGIAYEVRGK-QIELSLEHLDVRESVLGGYITKLVKFYPQDEGEEGAVLALVYIATPQNPRYLGP-ASEEEIAAQIVACSGCAGHNIEYLLRLAEFMHNCCPNAE----DKHLFSIEEAL 191
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Xenopus
Match: cyyr1 (cysteine and tyrosine-rich 1 [Source:Xenbase;Acc:XB-GENE-854805])

HSP 1 Score: 125.561 bits (314), Expect = 1.346e-34
Identity = 67/182 (36.81%), Postives = 103/182 (56.59%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVT-NEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
            +W FGY SLIWK  F Y  ++VG I  Y RRF+QG+T HRG P  PGRV T+++D    VWGVAY +   ++E +KA +   E+    GGY      F+P +    P  + +Y+   +N  YLG    ++  A QI  A G  G+N+EY+ ++   ++N + +      D++LF L +L+ +
Sbjct:    1 MWVFGYGSLIWKVDFPYVEKLVGYITCYSRRFWQGSTDHRGVPGKPGRVVTLVEDPEGCVWGVAYRLPEGKEEEVKAYLDFREK----GGYRTSTGVFYPKDPSIKPFNVLLYIGTCDNPDYLGP-APLEDIAEQILNAVGPSGRNTEYLFELANSLRNLVPE----DADEHLFSLERLVRQ 173
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Xenopus
Match: sgcg (sarcoglycan gamma [Source:Xenbase;Acc:XB-GENE-956423])

HSP 1 Score: 125.561 bits (314), Expect = 3.458e-34
Identity = 72/200 (36.00%), Postives = 107/200 (53.50%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLN-NLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKVRQTIPI 785
            +LW FGY SL+WKP F +++  VG + GY R+F+QG T HRG+P+      T+    S   WG+AYEV  + +I  +L HL  RE + GGY    V F+P +   +  +   VY+A P+N +YLG   S +  A QI    G  G N EY+ ++ EFM N          D++LF + + +      F P+E+     P+
Sbjct:   17 SLWIFGYGSLVWKPNFEFTSSKVGFVPGYSRKFWQGDTFHRGSPQMVSIPPTMYNGISECTWGIAYEVRGK-QIELSLEHLDVRESVLGGYITKLVKFYPQDEGEEGAVLALVYIATPQNPRYLGP-ASEEEIAAQIVACSGCAGHNIEYLLRLAEFMHNCCPNAE----DKHLFSIEEALVALFVLFGPAEQAFAGSPV 210
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Xenopus
Match: sgcg (sarcoglycan gamma [Source:Xenbase;Acc:XB-GENE-956423])

HSP 1 Score: 122.094 bits (305), Expect = 6.507e-33
Identity = 68/185 (36.76%), Postives = 101/185 (54.59%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLN-NLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQ 740
            +LW FGY SL+WKP F +++  VG + GY R+F+QG T HRG+P+      T+    S   WG+AYEV  + +I  +L HL  RE + GGY    V F+P +   +  +   VY+A P+N +YLG   S +  A QI    G  G N EY+ ++ EFM N          D++LF + + +  + 
Sbjct:   17 SLWIFGYGSLVWKPNFEFTSSKVGFVPGYSRKFWQGDTFHRGSPQMVSIPPTMYNGISECTWGIAYEVRGK-QIELSLEHLDVRESVLGGYITKLVKFYPQDEGEEGAVLALVYIATPQNPRYLGP-ASEEEIAAQIVACSGCAGHNIEYLLRLAEFMHNCCPNAE----DKHLFSIEEALVAFH 195
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Xenopus
Match: cyyr1 (cysteine and tyrosine-rich 1 [Source:Xenbase;Acc:XB-GENE-854805])

HSP 1 Score: 103.219 bits (256), Expect = 3.089e-26
Identity = 61/182 (33.52%), Postives = 94/182 (51.65%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVT-NEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
            +W FGY SLIWK  F Y  ++VG I  Y RRF+QG+T HRG P                VWGVAY +   ++E +KA +   E+    GGY      F+P +    P  + +Y+   +N  YLG    ++  A QI  A G  G+N+EY+ ++   ++N + +      D++LF L +L+ +
Sbjct:    1 MWVFGYGSLIWKVDFPYVEKLVGYITCYSRRFWQGSTDHRGVP------------GKGCVWGVAYRLPEGKEEEVKAYLDFREK----GGYRTSTGVFYPKDPSIKPFNVLLYIGTCDNPDYLGP-APLEDIAEQILNAVGPSGRNTEYLFELANSLRNLVPE----DADEHLFSLERLVRQ 161
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Mouse
Match: Chac1 (ChaC, cation transport regulator 1 [Source:MGI Symbol;Acc:MGI:1916315])

HSP 1 Score: 145.976 bits (367), Expect = 4.464e-42
Identity = 71/158 (44.94%), Postives = 100/158 (63.29%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMK 662
            ALW FGY SL+WKP F+YS+  VG ++GY RRF+QG T HRG+ + PGRV T+++D     WGVAY+V  E ++ +AL +L  RE + GGY   +VTF+P +    P+    YVA P+N  YLG     +  A QI   +G  G N EY+ ++ +FM+
Sbjct:   33 ALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGE-QVNEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPE-EVIATQILACRGFSGHNLEYLLRLADFMQ 188
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Mouse
Match: Chac2 (ChaC, cation transport regulator 2 [Source:MGI Symbol;Acc:MGI:1915294])

HSP 1 Score: 129.798 bits (325), Expect = 2.289e-36
Identity = 68/186 (36.56%), Postives = 107/186 (57.53%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNG 746
            +W FGY SLIWK  F Y +++VG I  Y RRF+QG+T HRG P  PGRV T+++D    VWGVAY++   ++E +K  +   E+    GGY    V F+P ++   P  + +Y+   +N  YLG    ++  A QI  A G  G+N+EY+ ++ + ++  + +      D++LF L KL+ +   G
Sbjct:    1 MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPGGSVWGVAYKLPVGKEEEVKTYLDFREK----GGYRTTTVIFYPKDSTTKPFSVLLYIGTCDNPNYLGP-APLEDIAEQIFNAAGPSGRNTEYLFELADSVRKLVPEDA----DEHLFSLEKLVKERLEG 177
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Mouse
Match: Chac2 (ChaC, cation transport regulator 2 [Source:MGI Symbol;Acc:MGI:1915294])

HSP 1 Score: 107.457 bits (267), Expect = 4.870e-28
Identity = 62/186 (33.33%), Postives = 98/186 (52.69%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNG 746
            +W FGY SLIWK  F Y +++VG I  Y RRF+QG+T HRG P                VWGVAY++   ++E +K  +   E+    GGY    V F+P ++   P  + +Y+   +N  YLG    ++  A QI  A G  G+N+EY+ ++ + ++  + +      D++LF L KL+ +   G
Sbjct:    1 MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVP------------GKGSVWGVAYKLPVGKEEEVKTYLDFREK----GGYRTTTVIFYPKDSTTKPFSVLLYIGTCDNPNYLGP-APLEDIAEQIFNAAGPSGRNTEYLFELADSVRKLVPEDA----DEHLFSLEKLVKERLEG 165
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. UniProt/SwissProt
Match: sp|Q9BUX1|CHAC1_HUMAN (Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Homo sapiens OX=9606 GN=CHAC1 PE=1 SV=3)

HSP 1 Score: 150.984 bits (380), Expect = 3.440e-43
Identity = 78/193 (40.41%), Postives = 114/193 (59.07%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKV 767
            ALW FGY SL+W+P F+YS+  VG ++GY RRF+QG T HRG+ + PGRV T+++D     WGVAY+V  E ++ KAL +L  RE + GGY   +VTF+P +    P++   YVA P+N  YLG     +A A QI   +G  G N EY+ ++ +FM+    Q      D++L  +   +      F P+E+ 
Sbjct:   32 ALWIFGYGSLVWRPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGE-QVSKALKYLNVREAVLGGYDTKEVTFYPQDAPDQPLKALAYVATPQNPGYLGPAPE-EAIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQ----DEHLAAIVDAVGTMLPCFCPTEQA 218
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. UniProt/SwissProt
Match: sp|B3STU3|CHAC1_RAT (Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Rattus norvegicus OX=10116 GN=Chac1 PE=2 SV=1)

HSP 1 Score: 147.132 bits (370), Expect = 1.161e-41
Identity = 71/158 (44.94%), Postives = 100/158 (63.29%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMK 662
            ALW FGY SL+WKP F+YS+  VG ++GY RRF+QG T HRG+ + PGRV T+++D     WGVAY+V  E ++ +AL +L  RE + GGY   +VTF+P +    P+    YVA P+N  YLG     +  A QI   +G  G N EY+ ++ +FM+
Sbjct:   32 ALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVRGE-QVSEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPE-EVIATQILACRGFSGHNLEYLLRLADFMQ 187
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. UniProt/SwissProt
Match: sp|Q5SPB6|CHAC1_DANRE (Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Danio rerio OX=7955 GN=chac1 PE=3 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 1.459e-41
Identity = 77/167 (46.11%), Postives = 103/167 (61.68%), Query Frame = 3 
Query:  162 ETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMK 662
            + +V  KS +LW FGY SL+WKP F Y    VG IKGYKRRF+ G   HRG  E PGRV T+I++D    WGVA+EVT   ++ ++L +L  RE + GGY    V FFP    + P++  VY+A P+N  YLG   S +  A QIA  +G  G N EY+ ++ EFM+
Sbjct:    4 QDIVAGKS-SLWIFGYGSLVWKPDFKYKRSKVGYIKGYKRRFWHGDNFHRGDDEMPGRVVTLIEEDDVCTWGVAFEVTGS-QMEESLKYLNVREAVRGGYLTRAVDFFPRGTNQPPVQALVYIATPDNPIYLGP-ASTEEIASQIAVCKGNSGHNIEYLLRLAEFMR 167
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. UniProt/SwissProt
Match: sp|Q8R3J5|CHAC1_MOUSE (Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Mus musculus OX=10090 GN=Chac1 PE=1 SV=2)

HSP 1 Score: 145.976 bits (367), Expect = 3.122e-41
Identity = 71/158 (44.94%), Postives = 100/158 (63.29%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMK 662
            ALW FGY SL+WKP F+YS+  VG ++GY RRF+QG T HRG+ + PGRV T+++D     WGVAY+V  E ++ +AL +L  RE + GGY   +VTF+P +    P+    YVA P+N  YLG     +  A QI   +G  G N EY+ ++ +FM+
Sbjct:   33 ALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGE-QVNEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPE-EVIATQILACRGFSGHNLEYLLRLADFMQ 188
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. UniProt/SwissProt
Match: sp|Q8WUX2|CHAC2_HUMAN (Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 1.204e-36
Identity = 70/186 (37.63%), Postives = 108/186 (58.06%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNG 746
            +W FGY SLIWK  F Y +++VG I  Y RRF+QG+T HRG P  PGRV T+++D +  VWGVAY +   ++E +KA +   E+    GGY    V F+P +    P  + +Y+   +N  YLG    ++  A QI  A G  G+N+EY+ ++   ++N + +    + D++LF L KL+ +   G
Sbjct:    1 MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPAGCVWGVAYRLPVGKEEEVKAYLDFREK----GGYRTTTVIFYPKDPTTKPFSVLLYIGTCDNPDYLGP-APLEDIAEQIFNAAGPSGRNTEYLFELANSIRNLVPE----EADEHLFALEKLVKERLEG 177
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. TrEMBL
Match: A0A0R3SXP4 (Gamma-glutamylcyclotransferase OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS10531 PE=3 SV=1)

HSP 1 Score: 199.519 bits (506), Expect = 4.024e-59
Identity = 103/200 (51.50%), Postives = 135/200 (67.50%), Query Frame = 3 
Query:  168 MVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIK--DDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPL-----NNLKTP---IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKY 737
            M+CP++  L+ FGY SLIWKP  +YS   VG IKGYKRRFYQGTTTHRGTPE PGRV T++   D  + VWG  +EV   +EI  A+ HLAEREMI GGY FD V F+P      NN + P   I  +VY+A+P N QY+G    ++ QA QIA A G CG NSEY+ K++EF+  E+  ++ + +D+Y F+L  L+N+Y
Sbjct:   21 MLCPETGKLYIFGYGSLIWKPNINYSRSWVGYIKGYKRRFYQGTTTHRGTPEQPGRVLTLLPSIDKEARVWGKVFEVDGVEEINAAIEHLAEREMILGGYRFDAVPFYPFKNCEKNNCEQPQEVIRSFVYIAEPGNDQYIGK-APLEVQARQIALAHGFCGPNSEYLRKLIEFIIKEVP-KDELHHDKYSFDLWYLVNEY 218
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. TrEMBL
Match: A0A564Z0U8 (Gamma-glutamylcyclotransferase OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS11415 PE=3 SV=1)

HSP 1 Score: 199.134 bits (505), Expect = 4.631e-59
Identity = 103/200 (51.50%), Postives = 135/200 (67.50%), Query Frame = 3 
Query:  168 MVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIK--DDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPL-----NNLKTP---IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKY 737
            M+CP++  L+ FGY SLIWKP  +YS   VG IKGYKRRFYQGTTTHRGTPE PGRV T++   D  + VWG  +EV   +EI  A+ HLAEREMI GGY FD V F+P      NN + P   I  +VY+A+P N QY+G    ++ QA QIA A G CG NSEY+ K++EF+  E+  ++ + +D+Y F+L  L+N+Y
Sbjct:   21 MLCPETGKLYIFGYGSLIWKPNINYSRSWVGYIKGYKRRFYQGTTTHRGTPEQPGRVLTLLPSIDKEARVWGKVFEVDGVEEINAAIEHLAEREMILGGYRFDAVPFYPFKNCEKNNCEQPQEVIRSFVYIAEPGNDQYIGK-APLEVQARQIALAHGFCGPNSEYLRKLIEFIIKEVP-KDELHHDKYSFDLWYLVNEY 218
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. TrEMBL
Match: A0A068WF22 (Gamma-glutamylcyclotransferase OS=Echinococcus granulosus OX=6210 GN=EgrG_000864000 PE=3 SV=1)

HSP 1 Score: 195.667 bits (496), Expect = 6.741e-58
Identity = 101/210 (48.10%), Postives = 138/210 (65.71%), Query Frame = 3 
Query:  168 MVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATII--KDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPL-------------NNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFE 752
            M+CP +  L+ FGY SLIW+P  SY+    G IKGYK RFYQGTTTHRGTP++PGRV T++  K+  + VWG AYEV   ++I  A+ HLAEREMI GGY FD+V+FFP              + L   I  +VY+A+P N QYLG    ++ QA+QIA A G CG+N EY+ K+V+F+ +E+  +N I+ DQY+  L +L+ +Y +  E
Sbjct:    1 MICPGNGKLYIFGYGSLIWRPNISYTRSWSGYIKGYKIRFYQGTTTHRGTPQYPGRVVTLLPSKNKEARVWGKAYEVDGAEQINAAIEHLAEREMILGGYKFDEVSFFPRRVIHENPEGQQNESQLPDVIRAFVYIAEPGNDQYLGK-APLEVQAHQIATAVGHCGRNVEYLQKLVDFINSEVP-KNDIRNDQYILNLWRLVKEYSHNAE 208
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. TrEMBL
Match: A0A0R3T237 (Gamma-glutamylcyclotransferase OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS973 PE=3 SV=1)

HSP 1 Score: 192.2 bits (487), Expect = 2.451e-56
Identity = 102/206 (49.51%), Postives = 134/206 (65.05%), Query Frame = 3 
Query:  159 KETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEW---PGRVATII--KDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNL------KTP--IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKY 737
            +  M+CP+S  L+ FGY SLIWKP  +YS   +G IKGYKRRFYQGTTTHRGTP+    PGRV T++   D    VWG  +EV   DEI  A+ HLAEREMI GGY FD V F+P  N       ++P  I+  VY+A+P N QY+G    ++ QA QIA A G CG NSEY+ K++EF+  E+ + N + +D+Y  +L  L+N+Y
Sbjct:   18 RPEMLCPESGKLYIFGYGSLIWKPNITYSRSWIGYIKGYKRRFYQGTTTHRGTPQQASEPGRVLTLLPSSDKEQRVWGKLFEVDGVDEINAAIEHLAEREMILGGYRFDVVPFYPFKNCENNNYEQSPEVIQSIVYIAEPGNDQYIGK-APLEVQARQIAIAHGFCGPNSEYLKKLIEFIIEEVPKDN-LHHDKYSLDLWNLVNEY 221
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. TrEMBL
Match: A0A0X3QFB1 (Gamma-glutamylcyclotransferase (Fragment) OS=Schistocephalus solidus OX=70667 GN=TR97098 PE=3 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 3.638e-56
Identity = 101/221 (45.70%), Postives = 144/221 (65.16%), Query Frame = 3 
Query:  147 VEYLKETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATII--KDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTF------FPLNN----------LKTP----IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQN 743
            V +L+  MV P++  L+ FGY SLIWKP  +YS   VG I+GY RRFYQGTTTHRGTPEWPGRVAT++  ++  + VWGV YE+    +I  AL HLAEREMITGGY FD+V F      F   N          L  P    + + VY+A+P N QY+G+   ++ QA QIAKA G CG N +Y+ ++V+F++ E+ + + + +++YL +L++L+  Y++
Sbjct:   45 VSFLRSQMVNPRTGKLYIFGYGSLIWKPNITYSRSWVGYIEGYNRRFYQGTTTHRGTPEWPGRVATLVPARNAKTRVWGVTYEIQGRKDIDAALEHLAEREMITGGYRFDEVDFVARKLIFAAPNSPEDEWSKDLLVKPEPARLNVQVYIAEPGNPQYIGD-APLEVQANQIAKATGHCGPNVDYLFRLVDFVRQEVPKEDLL-FEKYLLDLSQLVEDYRS 263
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Cavefish
Match: chac1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:NCBI gene;Acc:103029103])

HSP 1 Score: 142.124 bits (357), Expect = 6.209e-41
Identity = 74/180 (41.11%), Postives = 106/180 (58.89%), Query Frame = 3 
Query:  183 SMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNK 722
            S +LW FGY SL+WKP F +    VG ++GYKRRF+ G   HRG  E PGRV T+I++D +  WGVA+EVT   ++ ++L +L  RE + GGY    V F P    + PI+  VY+A  +N  YLG   S D  A QIA  +G  G N EY+ ++ +FM++     +    D +LF + +
Sbjct:   13 SSSLWIFGYGSLVWKPDFKFKRSKVGFVRGYKRRFWHGDNFHRGNDETPGRVVTLIEEDDASTWGVAFEVTGS-QVEESLKYLNVREAVRGGYLTRFVEFVPRGENQVPIQALVYIATADNPIYLGP-ASTDEIAAQIAVCKGKTGHNIEYLLRLADFMRHSCPDVD----DPHLFSIER 186
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Cavefish
Match: chac2 (ChaC cation transport regulator homolog 2 [Source:NCBI gene;Acc:103027661])

HSP 1 Score: 123.635 bits (309), Expect = 5.100e-34
Identity = 66/181 (36.46%), Postives = 104/181 (57.46%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLIN 731
            +W FGY SLIWK  F Y  + VG I+G+ RRF+QG+T HRG P  PGRV T+I+D    VWGVAY++ +  ++ +K  +   E+    GGY    VTF P    +   +  +Y+   +N  YLG    ++  A QI K+ G  G+N+EY+ ++ E ++  + + +    D +LF L +++ 
Sbjct:    1 MWVFGYGSLIWKVDFPYEEKRVGFIRGFSRRFWQGSTDHRGVPGKPGRVVTLIEDPEGCVWGVAYKLPSGREKEVKEYLDYREK----GGYSVLTVTFHPKEEDEPMQDTLLYIGSHDNPNYLGP-APLELIAQQILKSVGPSGRNTEYLFELAEALRQLVPEDS----DDHLFSLERMVK 172
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Cavefish
Match: chac2 (ChaC cation transport regulator homolog 2 [Source:NCBI gene;Acc:103027661])

HSP 1 Score: 100.908 bits (250), Expect = 1.502e-25
Identity = 59/181 (32.60%), Postives = 95/181 (52.49%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEV-TNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLIN 731
            +W FGY SLIWK  F Y  + VG I+G+ RRF+QG+T HRG P                VWGVAY++ +  ++ +K  +   E+    GGY    VTF P    +   +  +Y+   +N  YLG    ++  A QI K+ G  G+N+EY+ ++ E ++  + + +    D +LF L +++ 
Sbjct:    1 MWVFGYGSLIWKVDFPYEEKRVGFIRGFSRRFWQGSTDHRGVP------------GKGCVWGVAYKLPSGREKEVKEYLDYREK----GGYSVLTVTFHPKEEDEPMQDTLLYIGSHDNPNYLGP-APLELIAQQILKSVGPSGRNTEYLFELAEALRQLVPEDS----DDHLFSLERMVK 160
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Sea Lamprey
Match: chac1 (ChaC, cation transport regulator homolog 1 (E. coli) [Source:NCBI gene;Acc:563855])

HSP 1 Score: 137.502 bits (345), Expect = 5.457e-40
Identity = 72/166 (43.37%), Postives = 97/166 (58.43%), Query Frame = 3 
Query:  168 MVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKN 665
            M+   + +LW FGY SL+W+PGF+YS   VG ++GY RRF+QG   HRGTP+ PGRV T+I+D  +  WGVA+EV +  EI  AL HLA RE   GGY    V F  +      +   VY+A P N Q++G   S  A    +A   G  G N EYV ++ + M+ 
Sbjct:    3 MLGEVASSLWLFGYGSLVWRPGFAYSAVRVGFVRGYSRRFWQGDCEHRGTPQQPGRVVTLIEDKDACTWGVAFEVRSH-EIAPALAHLAVREQELGGYDTRFVDF--VTEEGDAVTALVYIATPHNHQFVGP-ASPQAIGAVVAGCSGHAGHNVEYVLRLAQAMRQ 164
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Sea Lamprey
Match: chac2 (ChaC, cation transport regulator homolog 2 (E. coli) [Source:NCBI gene;Acc:557614])

HSP 1 Score: 68.5514 bits (166), Expect = 1.393e-14
Identity = 42/137 (30.66%), Postives = 74/137 (54.01%), Query Frame = 3 
Query:  327 PGRVATIIKDDSSVVWGVAYEVTNE-DEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
            PGRV T++KD  + VWGVAY++ ++  E +K  + + E+    GGY+   V F+P      P    +YV   +N  +LG    ++  A QI  + G  GQN+EY+ ++   M+  + +      DQ+L+ L +++ +
Sbjct:    2 PGRVVTLVKDPGNSVWGVAYKIRDDLREDVKRTLDIREQ----GGYNTSFVMFYPREVENEPFLSMLYVGTEDNPNFLG-PAPMEEIAQQILMSSGPSGQNTEYLFELANTMRRLVPE----APDQHLYTLEEMVRE 129
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Yeast
Match: GCG1 (Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle [Source:SGD;Acc:S000000965])

HSP 1 Score: 81.2629 bits (199), Expect = 1.225e-18
Identity = 68/228 (29.82%), Postives = 101/228 (44.30%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATII-------------------------KDDSSVVWGVAYEVTNE--DEILKAL---------IHLAEREMITGGYH----FDKVTFFPLNNL--KTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNE--IDQRNWIKYDQYLFELNKLINKYQ 740
             +W  GY SLI+KP   Y++RI   I G+ RRF+Q +T HRGTP  PGRVAT+I                           D  V  GV Y +  E   E+ + L         +H  E  + T   H     + +   P +N   K  +   VY+   +N  ++G   ++D  A  IA + G  G N EY+ K+ + +     + +R  I  D YL  L + +NKY+
Sbjct:    7 GIWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTDHRGTPANPGRVATLIPYEDIIRQTAFLKNVNLYSESAPIQDPDDLVTIGVVYYIPPEHAQEVREYLNVREQNGYTLHEVEVHLETNREHEAELGEALEQLPRHNKSGKRVLLTSVYIGTIDNEAFVG-PETVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPIMKERGRIT-DHYLTALLETVNKYR 232
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Nematostella
Match: EDO40292 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7S8])

HSP 1 Score: 149.828 bits (377), Expect = 5.138e-44
Identity = 76/181 (41.99%), Postives = 111/181 (61.33%), Query Frame = 3 
Query:  183 SMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKL 725
            S ++W FGY SLIWKP F+Y   +VG I+G++R+F+QG+  HRG  E PGRV T+ +     VWGVAY+V+ ED I  AL  L +RE+  GGY    +TF+P +    P    +Y A PEN  Y G   + +  A QI  A GV G N EY+ ++ +FM++++ Q      D++LF ++K+
Sbjct:   20 SDSIWVFGYGSLIWKPDFTYERSVVGHIRGFERKFWQGSVWHRGNEETPGRVVTLEEHLEGQVWGVAYKVSGED-IDTALGRLNKREIALGGYELHNLTFYPQDQSLEPFNALLYAATPENSLYFGK-ETPEKLALQIVSAHGVSGPNVEYLFRIADFMRSKVPQVE----DKHLFAVDKI 194
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Nematostella
Match: EDO49305 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH77])

HSP 1 Score: 143.665 bits (361), Expect = 5.688e-42
Identity = 78/193 (40.41%), Postives = 114/193 (59.07%), Query Frame = 3 
Query:  162 ETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDE--ILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
            +  V  +   LW FGY SL+WK  F Y  ++ G IKGY R+FYQG+  HRG P  PGRVAT++ D  S VWG++Y+V  +DE  +L+ L  + E++  T G+     TF P  NL+   ++ +YVA  EN  YLG    +   AYQIA ++G  G+NSEY+  +   ++   +  +  + D +LFEL KL+ K
Sbjct:    4 DNFVLEEGQDLWIFGYGSLVWKVNFPYKKKVAGYIKGYVRKFYQGSCDHRGVPGKPGRVATLLPDSKSTVWGISYQVDAQDEPSVLRYL-DIREKDGYTAGF----TTFHPSGNLEEQFQVMLYVATQENEFYLGP-APLPEIAYQIAHSKGTSGKNSEYLLNLAAVIEKITEHDH--QCDNHLFELEKLVKK 188
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Medaka
Match: chac1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:NCBI gene;Acc:101167586])

HSP 1 Score: 151.754 bits (382), Expect = 1.299e-44
Identity = 78/176 (44.32%), Postives = 106/176 (60.23%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFEL 716
            +LW FGY SL+WKP F Y    VG I+GYKRRF+ G   HRG+   PGRV T+I+DD +V WGVA+EV+   ++ +AL +L  RE + GGY    V FFP +    P++  VY+A  +N  YLG     D  A QIA + G  G N EY+ ++ EFM++   Q      DQ+LF +
Sbjct:   11 SLWIFGYGSLVWKPDFKYRKSRVGFIRGYKRRFWHGDDFHRGSQAAPGRVVTLIEDDDAVTWGVAFEVSGP-QVEEALAYLNVRETVCGGYVTKMVDFFPGDEGPAPVQALVYIATSDNPLYLGPASPEDIGA-QIASSSGKSGHNLEYLLRLAEFMRSSCPQVE----DQHLFSV 180
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Medaka
Match: chac1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:NCBI gene;Acc:101167586])

HSP 1 Score: 148.288 bits (373), Expect = 1.452e-43
Identity = 74/163 (45.40%), Postives = 100/163 (61.35%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQ 677
            +LW FGY SL+WKP F Y    VG I+GYKRRF+ G   HRG+   PGRV T+I+DD +V WGVA+EV+   ++ +AL +L  RE + GGY    V FFP +    P++  VY+A  +N  YLG     D  A QIA + G  G N EY+ ++ EFM++   Q
Sbjct:   11 SLWIFGYGSLVWKPDFKYRKSRVGFIRGYKRRFWHGDDFHRGSQAAPGRVVTLIEDDDAVTWGVAFEVSGP-QVEEALAYLNVRETVCGGYVTKMVDFFPGDEGPAPVQALVYIATSDNPLYLGPASPEDIGA-QIASSSGKSGHNLEYLLRLAEFMRSSCPQ 171
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Medaka
Match: ENSORLT00000031171.1 (glutathione-specific gamma-glutamylcyclotransferase 1 [Source:NCBI gene;Acc:101169827])

HSP 1 Score: 143.665 bits (361), Expect = 1.785e-41
Identity = 72/158 (45.57%), Postives = 99/158 (62.66%), Query Frame = 3 
Query:  189 ALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMK 662
            +LW FGY SL+WKPGF +    VG IKGYKRRF+ G   HRG  + PGRV T++ DD +  WGVAYEV+ E +I + L +L  RE++ GGY  + V F P  N +  +   VY+A  +N  YLG     +  A QI+  +G  G N+EY+ ++VEFM+
Sbjct:   15 SLWIFGYGSLVWKPGFRFRKSKVGHIKGYKRRFWHGDDFHRGDKDKPGRVVTLVADDEACTWGVAYEVS-ESQIEETLQYLNIREVVFGGYTTEMVEFIPKENNQDTLLALVYIATSDNPIYLGPASDKEIAA-QISICRGNTGHNTEYLQRLVEFMR 170
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Medaka
Match: chac2 (ChaC cation transport regulator homolog 2 [Source:NCBI gene;Acc:101167244])

HSP 1 Score: 128.642 bits (322), Expect = 8.124e-36
Identity = 73/184 (39.67%), Postives = 106/184 (57.61%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVT--NEDEILKALIHLAEREMITGGYHFDKVTFFPL-NNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
            +W FGY SLIWK  F Y  + VG IKG+ RRF+QG+T HRG P  PGRV T+++D    VWGVAY++    E E+   L H   RE   GGY    V F+P  ++  +P E  +Y+    N  YLG   S+D  A QI  + G  G+N+EY+ K+ + +++ + + +    D +LF L  L+ +
Sbjct:    1 MWVFGYGSLIWKVDFPYQEKRVGYIKGFSRRFWQGSTDHRGVPGKPGRVVTVVEDPEGCVWGVAYKLPEGREQEVKDYLDH---RE--KGGYQVITVPFYPRPSSTSSPCETLLYIGSQGNPNYLGP-ASMDDIANQIINSTGPSGKNTEYLFKLADAVRSILPEDS----DAHLFSLESLVRE 174
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Medaka
Match: chac2 (ChaC cation transport regulator homolog 2 [Source:NCBI gene;Acc:101167244])

HSP 1 Score: 104.375 bits (259), Expect = 1.370e-26
Identity = 62/163 (38.04%), Postives = 93/163 (57.06%), Query Frame = 3 
Query:  255 VGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVT--NEDEILKALIHLAEREMITGGYHFDKVTFFPL-NNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
            VG IKG+ RRF+QG+T HRG P  PGRV T+++D    VWGVAY++    E E+   L H   RE   GGY    V F+P  ++  +P E  +Y+    N  YLG   S+D  A QI  + G  G+N+EY+ K+ + +++ + + +    D +LF L  L+ +
Sbjct:   21 VGYIKGFSRRFWQGSTDHRGVPGKPGRVVTVVEDPEGCVWGVAYKLPEGREQEVKDYLDH---REK--GGYQVITVPFYPRPSSTSSPCETLLYIGSQGNPNYLGP-ASMDDIANQIINSTGPSGKNTEYLFKLADAVRSILPEDS----DAHLFSLESLVRE 173
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Planmine SMEST
Match: SMESG000028525.1 (SMESG000028525.1)

HSP 1 Score: 459.529 bits (1181), Expect = 2.365e-165
Identity = 218/218 (100.00%), Postives = 218/218 (100.00%), Query Frame = 3 
Query:  132 MVNISVEYLKETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKVRQTIPI 785
            MVNISVEYLKETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKVRQTIPI
Sbjct:    1 MVNISVEYLKETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGFEPSEKVRQTIPI 218
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Planmine SMEST
Match: SMESG000028527.1 (SMESG000028527.1)

HSP 1 Score: 209.534 bits (532), Expect = 6.587e-67
Identity = 103/211 (48.82%), Postives = 146/211 (69.19%), Query Frame = 3 
Query:  150 EYLKETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQNGF-EPSEKVRQTI 779
            EY + + +   +  +  FGY SLIWKP F +++R+VG I+GYKRRFYQ + THRGT E PGRVATIIKD+ S VWGV+Y +  E++I KAL HL  RE+ TGGY  +++ F+P +    P    VYVA  +N  ++G+GGS++ QAYQI KA+G CG+N EYV KV +FM+NE+  +NW ++D YL++L +LI  ++ G   PS  +  T+
Sbjct:    7 EYNRNSEMLSDTKCISIFGYGSLIWKPEFEFNSRVVGFIQGYKRRFYQSSVTHRGTVESPGRVATIIKDNKSTVWGVSYRIIGEEKISKALEHLFGREIQTGGYCNEEILFYPNDITAEPHITNVYVALEDNDLFVGSGGSLEIQAYQIVKAKGFCGRNIEYVAKVADFMENEL-TKNWEEFDPYLYKLMRLIRAFEKGVRRPSSSIVHTV 216
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Planmine SMEST
Match: SMESG000008876.1 (SMESG000008876.1)

HSP 1 Score: 145.206 bits (365), Expect = 8.154e-42
Identity = 79/205 (38.54%), Postives = 116/205 (56.59%), Query Frame = 3 
Query:  192 LWTFGYASLIWKPGFSYS-NRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLN-NLKTP-------------------IEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINKYQN 743
             + FGY SLIW PGF ++ N I+G    + RRFYQG+   RGTPEWPGRVAT++    S  WG+AY VT+   ++K + HL EREM+ G Y   K+ F P    L  P                   I    Y+A+  N QY+G   SID +++QI +A G+ G N+EYV K+ +F ++++   N ++ D YL E+ + +  ++N
Sbjct:   19 FFIFGYGSLIWNPGFEHAGNPIIGFACEHVRRFYQGSQNFRGTPEWPGRVATLVPISHSRTWGLAYRVTHPASVIKTIDHLIEREMVAGEYQQLKICFHPFKPTLGDPDFSEDINTYPCCCYENSVMINAITYIANTSNSQYIG-PASIDVESFQIFQASGIAGTNTEYVEKIGKFHRDQVP--NGLEEDPYLKEIMRNLEMFKN 220
[Close]
BLAST of Gamma-glutamylcyclotransferase vs. Planmine SMEST
Match: SMESG000077716.1 (SMESG000077716.1)

HSP 1 Score: 106.686 bits (265), Expect = 3.092e-27
Identity = 72/184 (39.13%), Postives = 105/184 (57.07%), Query Frame = 3 
Query:  198 TFGYASLIWKPGFSYSNRIVGCIKGYKRRFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHLAEREMITGGYHFDKVTFFPLNNLKT-----PIEMYVYVADPENMQYLGNGGSIDAQAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLINK 734
             FGYASLI  P   Y NR +GCIK Y  R YQG+    G+ +WPGRVAT++  D ++ +GVA+ V +E ++ ++  +L  RE+    Y    + F+PL N  T     P  +  +VA P+N QYLG    ++ QAYQI KAQ     N+ YV  ++ F   +I Q   ++ D YL +L +LI +
Sbjct:   28 VFGYASLITFPHIKYYNRQIGCIKNYATRLYQGSIV-LGSLDWPGRVATLVPADGNLCFGVAFYVNDEAKV-ESWEYLNLREI---NYSLVSMEFYPLINDNTGVSNEPETVVTFVALPDNEQYLGE-CELELQAYQILKAQNK-WPNTRYVENLLAFYA-KIPQS--LQNDNYLVDLKELIER 201
The following BLAST results are available for this feature:
BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CHAC17.164e-4440.41ChaC glutathione specific gamma-glutamylcyclotrans... [more]
CHAC22.506e-3737.63ChaC cation transport regulator homolog 2 [Source:... [more]
CHAC13.368e-2431.09ChaC glutathione specific gamma-glutamylcyclotrans... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
F22F7.75.957e-2737.02Gamma-glutamylcyclotransferase [Source:UniProtKB/... [more]
F22F7.75.957e-2737.02Gamma-glutamylcyclotransferase [Source:UniProtKB/... [more]
F22F7.71.075e-2637.02Gamma-glutamylcyclotransferase [Source:UniProtKB/... [more]
F22F7.71.075e-2637.02Gamma-glutamylcyclotransferase [Source:UniProtKB/... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG103653.069e-4043.86gene:FBgn0039109 transcript:FBtr0084447[more]
CG103653.069e-4043.86gene:FBgn0039109 transcript:FBtr0084448[more]
CG103653.069e-4043.86gene:FBgn0039109 transcript:FBtr0084446[more]
CG103653.069e-4043.86gene:FBgn0039109 transcript:FBtr0084449[more]
CG25405.381e-2536.46gene:FBgn0030411 transcript:FBtr0073675[more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
chac11.932e-4246.11ChaC, cation transport regulator homolog 1 (E. col... [more]
chac21.318e-3536.02ChaC, cation transport regulator homolog 2 (E. col... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sgcg9.595e-3940.33sarcoglycan gamma [Source:Xenbase;Acc:XB-GENE-9564... [more]
cyyr11.346e-3436.81cysteine and tyrosine-rich 1 [Source:Xenbase;Acc:X... [more]
sgcg3.458e-3436.00sarcoglycan gamma [Source:Xenbase;Acc:XB-GENE-9564... [more]
sgcg6.507e-3336.76sarcoglycan gamma [Source:Xenbase;Acc:XB-GENE-9564... [more]
cyyr13.089e-2633.52cysteine and tyrosine-rich 1 [Source:Xenbase;Acc:X... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Chac14.464e-4244.94ChaC, cation transport regulator 1 [Source:MGI Sym... [more]
Chac22.289e-3636.56ChaC, cation transport regulator 2 [Source:MGI Sym... [more]
Chac24.870e-2833.33ChaC, cation transport regulator 2 [Source:MGI Sym... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9BUX1|CHAC1_HUMAN3.440e-4340.41Glutathione-specific gamma-glutamylcyclotransferas... [more]
sp|B3STU3|CHAC1_RAT1.161e-4144.94Glutathione-specific gamma-glutamylcyclotransferas... [more]
sp|Q5SPB6|CHAC1_DANRE1.459e-4146.11Glutathione-specific gamma-glutamylcyclotransferas... [more]
sp|Q8R3J5|CHAC1_MOUSE3.122e-4144.94Glutathione-specific gamma-glutamylcyclotransferas... [more]
sp|Q8WUX2|CHAC2_HUMAN1.204e-3637.63Glutathione-specific gamma-glutamylcyclotransferas... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0R3SXP44.024e-5951.50Gamma-glutamylcyclotransferase OS=Hymenolepis dimi... [more]
A0A564Z0U84.631e-5951.50Gamma-glutamylcyclotransferase OS=Hymenolepis dimi... [more]
A0A068WF226.741e-5848.10Gamma-glutamylcyclotransferase OS=Echinococcus gra... [more]
A0A0R3T2372.451e-5649.51Gamma-glutamylcyclotransferase OS=Rodentolepis nan... [more]
A0A0X3QFB13.638e-5645.70Gamma-glutamylcyclotransferase (Fragment) OS=Schis... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
chac16.209e-4141.11ChaC glutathione specific gamma-glutamylcyclotrans... [more]
chac25.100e-3436.46ChaC cation transport regulator homolog 2 [Source:... [more]
chac21.502e-2532.60ChaC cation transport regulator homolog 2 [Source:... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
chac15.457e-4043.37ChaC, cation transport regulator homolog 1 (E. col... [more]
chac21.393e-1430.66ChaC, cation transport regulator homolog 2 (E. col... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
GCG11.225e-1829.82Gamma-glutamyl cyclotransferase; cleaves the gamma... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO402925.138e-4441.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO493055.688e-4240.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
chac11.299e-4444.32ChaC glutathione specific gamma-glutamylcyclotrans... [more]
chac11.452e-4345.40ChaC glutathione specific gamma-glutamylcyclotrans... [more]
ENSORLT00000031171.11.785e-4145.57glutathione-specific gamma-glutamylcyclotransferas... [more]
chac28.124e-3639.67ChaC cation transport regulator homolog 2 [Source:... [more]
chac21.370e-2638.04ChaC cation transport regulator homolog 2 [Source:... [more]
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BLAST of Gamma-glutamylcyclotransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000028525.12.365e-165100.00SMESG000028525.1[more]
SMESG000028527.16.587e-6748.82SMESG000028527.1[more]
SMESG000008876.18.154e-4238.54SMESG000008876.1[more]
SMESG000077716.13.092e-2739.13SMESG000077716.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30026774 ID=SMED30026774|Name=Gamma-glutamylcyclotransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=945bp
ATAGTAGAATTATAAACAATTTTTATCGAAAATTGATTATCGTAATTCGA
CGGGTTTAAATAACATAATATATGTAAACTTCACAAATAATTTCATCATT
CGATATCAGGGATTTTTCTGGTCAGATTATAATGGTCAATATAAGCGTAG
AATATTTGAAAGAGACGATGGTCTGTCCCAAATCTATGGCCTTATGGACT
TTTGGATATGCTTCATTGATTTGGAAGCCCGGGTTTAGCTATTCTAATAG
AATTGTTGGTTGTATAAAAGGCTATAAACGTCGTTTCTATCAAGGCACAA
CTACTCACAGAGGTACACCAGAATGGCCAGGTCGTGTAGCAACTATTATT
AAAGATGACAGTAGTGTTGTGTGGGGTGTTGCATATGAAGTTACTAACGA
AGACGAAATATTAAAAGCTTTAATACACTTAGCTGAACGTGAAATGATTA
CTGGTGGCTATCATTTTGACAAAGTTACATTTTTTCCTCTGAACAATTTG
AAAACTCCTATAGAAATGTACGTTTATGTAGCTGATCCTGAAAATATGCA
ATATCTGGGTAATGGGGGATCGATAGATGCACAGGCATATCAAATTGCAA
AAGCTCAAGGTGTTTGTGGACAAAATTCAGAATATGTTAATAAAGTAGTA
GAATTTATGAAAAATGAAATCGACCAGAGAAATTGGATCAAATATGATCA
ATATTTATTTGAGTTAAACAAACTTATTAACAAATATCAAAATGGGTTTG
AACCTAGTGAAAAAGTAAGACAAACAATTCCAATATTAGTAAAGGAAGCC
AAAGAAGATGAAGAGCTCAAACTATTAAAGCTGAAATAATTTGAAATTTT
AACTCATTTTCAAGAATCTCAACATTATTATTTTTGGTGCTTTTTCCATT
CAGCTTCCATGTTTATATTTTTAAATATAATTTTTTAACACAAGC
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protein sequence of SMED30026774-orf-1

>SMED30026774-orf-1 ID=SMED30026774-orf-1|Name=SMED30026774-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=236bp
MVNISVEYLKETMVCPKSMALWTFGYASLIWKPGFSYSNRIVGCIKGYKR
RFYQGTTTHRGTPEWPGRVATIIKDDSSVVWGVAYEVTNEDEILKALIHL
AEREMITGGYHFDKVTFFPLNNLKTPIEMYVYVADPENMQYLGNGGSIDA
QAYQIAKAQGVCGQNSEYVNKVVEFMKNEIDQRNWIKYDQYLFELNKLIN
KYQNGFEPSEKVRQTIPILVKEAKEDEELKLLKLK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016829lyase activity
GO:0003839gamma-glutamylcyclotransferase activity
GO:0016740transferase activity
GO:0016746transferase activity, transferring acyl groups
Vocabulary: INTERPRO
TermDefinition
IPR036568GGCT-like_sf
IPR006840ChaC
IPR013024GGCT-like
Vocabulary: biological process
TermDefinition
GO:0006751glutathione catabolic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006840Glutathione-specific gamma-glutamylcyclotransferasePFAMPF04752ChaCcoord: 21..202
e-value: 2.9E-50
score: 170.8
IPR006840Glutathione-specific gamma-glutamylcyclotransferasePANTHERPTHR12192CATION TRANSPORT PROTEIN CHAC-RELATEDcoord: 17..205
NoneNo IPR availableGENE3DG3DSA:3.10.490.10coord: 10..197
e-value: 9.3E-14
score: 53.3
NoneNo IPR availablePANTHERPTHR12192:SF2GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1coord: 17..205
IPR013024Gamma-glutamyl cyclotransferase-likeCDDcd06661GGCT_likecoord: 24..134
e-value: 5.03383E-13
score: 61.2066
IPR036568Gamma-glutamyl cyclotransferase-like superfamilySUPERFAMILYSSF110857Gamma-glutamyl cyclotransferase-likecoord: 21..142