tRNA (Cytosine(34)-C(5))-methyltransferase

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMK--PSKSGEK-ESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W +F   +R  LPAT R+TG++  ++E+   +KNK+ ++L     ++ +   V  P  +P SWYP+E+AW  N S+  +RK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL++  HHK+LD+CAAPGSKT QL+EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNPIEDEAV+A++L +++G + L D+SN L GL    G+T+WKVM KD  W +  D VP +     R ++FPP D   + +++L+ C RILP +QNTGGFF+A+L K S +PW K  P   G+  E++ S   + A     + +DPS+++  P  +G    E                    +   +  + +  +     PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+  LLT + P   + S       + L+ G ++ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   43 KENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKEL---EDLEVDGQKVEVP--QPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQI----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLE-SPSFTGTGDTE-----------------IAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDAL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 705          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMK--PSKSGEK-ESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W +F   +R  LPAT R+TG+++                                        YP+E+AW  N S+  +RK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL++  HHK+LD+CAAPGSKT QL+EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNPIEDEAV+A++L +++G + L D+SN L GL    G+T+WKVM KD  W +  D VP +     R ++FPP D   + +++L+ C RILP +QNTGGFF+A+L K S +PW K  P   G+  E++ S   + A     + +DPS+++  P  +G    E                    +   +  + +  +     PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+  LLT + P   + S       + L+ G ++ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   43 KENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKR----------------------------------------YPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQI----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLE-SPSFTGTGDTE-----------------IAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDAL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 670          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHK 503
            ++N L   YY+ +      +W +F   +R  LPAT R+TG++  ++E+   +KNK+ ++L     ++ +   V  P  +P SWYP+E+AW  N S+  +RK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL++  HHK
Sbjct:   43 KENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKEL---EDLEVDGQKVEVP--QPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHK 179          

Query:   24 VKKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNT-------EKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
             ++   R R+ +YLN    K DL + Y  G F            +  EF        P T R    + + R+         L Q ++      N  V   PL K   W   +    +  S + I  TPE    H  L           Q A SMLP + L  + H ++LD+C APG KT+ + +++        TGV++AND  ++R   +V  L RL     ++   D   FP++         G     FDR+L D PCSG G + K+  +         +    LQ ++L  +++ +      GG +VY TCS+   E+E V+   L +    VRLV      TGL   + G TR                        FR   F P+      L+  RR  P   N  GFFIA  +K S
Sbjct:  251 AQREEGRSRS-EYLNR--LKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRD---------LAQALI------NRGVNLDPLGK---W--SKTGLVVYDSSVPIGATPEYLAGHYML-----------QGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKN------TGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVV-------GG-----FDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKR--NVRLVP-----TGLDFGQEGFTR------------------------FRERRFHPS------LRSTRRFYPHTHNMDGFFIAKFKKFS 584          

Query:   24 VKKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNT-------EKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
             ++   R R+ +YLN    K DL + Y  G F            +  EF        P T R    + + R+         L Q ++      N  V   PL K   W   +    +  S + I  TPE    H  L           Q A SMLP + L  + H ++LD+C APG KT+ + +++        TGV++AND  ++R   +V  L RL     ++   D   FP++         G     FDR+L D PCSG G + K+  +         +    LQ ++L  +++ +      GG +VY TCS+   E+E V+   L +    VRLV      TGL   + G TR                        FR   F P+      L+  RR  P   N  GFFIA  +K S
Sbjct:  251 AQREEGRSRS-EYLNR--LKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRD---------LAQALI------NRGVNLDPLGK---W--SKTGLVVYDSSVPIGATPEYLAGHYML-----------QGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKN------TGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVV-------GG-----FDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKR--NVRLVP-----TGLDFGQEGFTR------------------------FRERRFHPS------LRSTRRFYPHTHNMDGFFIAKFKKFS 584          

Query:   75 DRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQ-LQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVP-IAMRRSFRSSLFPPADVDS--LNLQYCRRILPQNQNTGGFFIALLEKVS 1256
            +++N+   +YYK    +  E+++EF   ++ +LP +FR  G  +   ++   ++N+F  +++     +  ++ V  P + P  WY +  A+Q   S+  +R  P L +LHNFL++E + G +SRQEAVSM+PPLLL   S H VLDLCAAPGSKT QL+EM+H   +  P G+VIAND++ KRCYM++H  L+R ++    V  +DA+ FP I      S S    + FDR+LADV CSGDGTLRKN ++W +W+P  G+  H +Q+ I R+  + L  GGRMVYSTCS+NPIEDEAV+A +L  ++G+++LVD S+ L  L  E+G+ +WKV  +D     S++++    M++   SSLFPP + ++  +NL +  RI P  Q+TGGFF+AL+EKVS
Sbjct:   39 EKENEKYWQYYKEQNVFPLEQFDEFRAALQRDLPVSFRFQGCHKDREQLIHEMENRFFGKIM-----EAGDTAVCVPKSLP--WYKE--AYQTPMSRTAVRSHPILAQLHNFLVTEAELGNLSRQEAVSMIPPLLLAPTSEHFVLDLCAAPGSKTTQLLEMIHENEEN-PKGMVIANDVDMKRCYMLIHHTLKRFRTAACAVTCEDAARFPHI------SDSDGGLIQFDRVLADVICSGDGTLRKNPEIWKKWTPQDGLGLHRMQIAIARKGAQQLKVGGRMVYSTCSMNPIEDEAVVAQLLRDSKGSLKLVDTSSLLPELKRETGVVQWKVFDRDMKLYKSLEDISEEKMKKVIVSSLFPPTEQEAKEMNLHFTMRITPHAQDTGGFFVALIEKVS 420          

Query: 1521 PPKKKARIFKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYR---NADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG-YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDV 2135
            P  KK ++FK++PF ++K DD+ W+ ++  Y + E F  Q L  R   + D   R  ++ N+ +K  V+ N  + ++  N G+K+F  +E +  N  +R+ QEG+  + +F+   +++ + T  D++ +L  D  L+       +   +    G V+    +  DD E +         W G  ++  Y+   ER HLLR+ G++  ++
Sbjct:  432 PAWKKKKMFKDEPFTFLKLDDERWNDIRNHYGVDESFLYQNLFSRRLESNDANSRQLFYANDAVKNFVKENMSK-VSIQNAGMKMFSRTEGKVENTRFRLSQEGIRYLFKFMQK-QKVKIGT-EDMLFMLKSDENLVPLEKLECKGDVRKQQNGTVV----VYCDDDEPV-------CTWVGYHTIAPYISKEERLHLLRMMGVDCAEI 626          

Query:  591 VVIANDIESKRCYMMVHQ-LQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVP-IAMRRSFRSSLFPPADVDS--LNLQYCRRILPQNQNTGGFFIALLEKVS 1256
            +VIAND++ KRCYM++H  L+R ++    V  +DA+ FP I      S S    + FDR+LADV CSGDGTLRKN ++W +W+P  G+  H +Q+ I R+  + L  GGRMVYSTCS+NPIEDEAV+A +L  ++G+++LVD S+ L  L  E+G+ +WKV  +D     S++++    M++   SSLFPP + ++  +NL +  RI P  Q+TGGFF+AL+EKVS
Sbjct:    1 MVIANDVDMKRCYMLIHHTLKRFRTAACAVTCEDAARFPHI------SDSDGGLIQFDRVLADVICSGDGTLRKNPEIWKKWTPQDGLGLHRMQIAIARKGAQQLKVGGRMVYSTCSMNPIEDEAVVAQLLRDSKGSLKLVDTSSLLPELKRETGVVQWKVFDRDMKLYKSLEDISEEKMKKVIVSSLFPPTEQEAKEMNLHFTMRITPHAQDTGGFFVALIEKVS 220          

Query: 1521 PPKKKARIFKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYR---NADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG-YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDV 2135
            P  KK ++FK++PF ++K DD+ W+ ++  Y + E F  Q L  R   + D   R  ++ N+ +K  V+ N  + ++  N G+K+F  +E +  N  +R+ QEG+  + +F+   +++ + T  D++ +L  D  L+       +   +    G V+    +  DD E +         W G  ++  Y+   ER HLLR+ G++  ++
Sbjct:  232 PAWKKKKMFKDEPFTFLKLDDERWNDIRNHYGVDESFLYQNLFSRRLESNDANSRQLFYANDAVKNFVKENMSK-VSIQNAGMKMFSRTEGKVENTRFRLSQEGIRYLFKFMQK-QKVKIGT-EDMLFMLKSDENLVPLEKLECKGDVRKQQNGTVV----VYCDDDEPV-------CTWVGYHTIAPYISKEERLHLLRMMGVDCAEI 426          

Query:  459 SMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLT----EGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPS---KSGEKESQPSP-METVASQETSEFSDPSEMK 1370
            S+LP + L  +   +VLD+C+APG KT+ +  ++        +GV+ AND    RC  ++  L RL     VV       F +I            P  FDRIL D PCSG G + K+Q +            H +Q +++  +L+ L      GG +VYSTCS+   E+EAV+  +L +      LV      TGL I   G TR                        FR   F P+      L   +R  P   N  GF++A ++K+S     K     K  EK +Q S   +  A  E SE SD  E K
Sbjct:   41 SLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMK------NSGVLFANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKI-----------RPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDANSPNGGYLVYSTCSVLVEENEAVVNFLLERRH--CELVP-----TGLSIGVDGYTR------------------------FRDYRFHPS------LSMTKRYYPHVHNIDGFYVAKIKKLSNAKMSKQGVMEKEKEKAAQKSQNKKNKAEAEASESSDDEEEK 299          

Query:  459 SMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLT----EGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPS---KSGEKESQPSP-METVASQETSEFSDPSEMK 1370
            S+LP + L  +   +VLD+C+APG KT+ +  ++        +GV+ AND    RC  ++  L RL     VV       F +I            P  FDRIL D PCSG G + K+Q +            H +Q +++  +L+ L      GG +VYSTCS+   E+EAV+  +L +      LV      TGL I   G TR                        FR   F P+      L   +R  P   N  GF++A ++K+S     K     K  EK +Q S   +  A  E SE SD  E K
Sbjct:  294 SLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKN------SGVLFANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKI-----------RPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDANSPNGGYLVYSTCSVLVEENEAVVNFLLERRH--CELVP-----TGLSIGVDGYTR------------------------FRDYRFHPS------LSMTKRYYPHVHNIDGFYVAKIKKLSNAKMSKQGVMEKEKEKAAQKSQNKKNKAEAEASESSDDEEEK 552          

Query: 1521 PPKKKARIFKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYR---NADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG-YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDV 2135
            P  KK ++FK++PF ++K DD+ W+ ++  Y + E F  Q L  R   + D   R  ++ N+ +K  V+ N  + ++  N G+K+F  +E +  N  +R+ QEG+  + +F+   +++ + T  D++ +L  D  L+       +   +    G V+    +  DD E +         W G  ++  Y+   ER HLLR+ G++  ++
Sbjct:   34 PAWKKKKMFKDEPFTFLKLDDERWNDIRNHYGVDESFLYQNLFSRRLESNDANSRQLFYANDAVKNFVKENMSK-VSIQNAGMKMFSRTEGKVENTRFRLSQEGIRYLFKFMQK-QKVKIGT-EDMLFMLKSDENLVPLEKLECKGDVRKQQNGTVV----VYCDDDEPV-------CTWVGYHTIAPYISKEERLHLLRMMGVDCAEI 228          

Query:   30 KRHNRGRANKYLNEEDRKNDLMMEYYK-GIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLI--VKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD--KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWC-SSIDEVPIAMRRSFRSSLFP-PAD-VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDR-SFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPL----ITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            KR +R +A  Y  E  R N   ++YY+        E+W +F  ++R  LP TFRVTGF+ +++ +  +I+ +   + +  V          V  PL  P  WYP+ +A+QL+ ++ +IR++  L +LHNFLI ET  G ISRQEAVSM+PP++LD+    KVLD+CAAPGSKTAQL+E LHA  +  KIP G V+AND+++ RCYM+VHQ +RL SPC++V   D+S+FP +    ++    K+ + FD+IL DVPCSGDGTLRKN D+W +W+     N H +Q +I+RR  EML  GGR+VYSTCSLNPIE+EAVL  I+  A G + LVD  + + GL  + G+T WK+  K+     +  +EVP ++    R  +FP PAD +  + L+ C R+LP  Q++GGFF+A+LEK   L + K             +E V   ET++   P+  +P     G P EE+                                S    P +KK R+  +KEDP+ +   +D  +  +K+FY++ E    + L+ R    K++N Y+ +E ++ LV  N++ +I  +N GVK F   E+R + + +R+ QEG++    F+G+ RR+ +  R DL+ +L    P       E  +  Q+  + L +G  + +Y  Q        R  L   GWRG SSLR YV   E  H+LRL G +
Sbjct:   23 KRTDR-QAQPY-EEIKRDNAFFIKYYQLQKICATDEEWTQFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLP--WYPNGLAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGSKTAQLIEALHAAPEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLVT--TKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGGRLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFEEVPESLHTIIRPGMFPLPADEMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDV----------VELVKLNETAK--QPA-AEPQVDADGKPIEEK--------------------------------SVPWGPQRKKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLV-LNNENNIKIINTGVKTFVRCENRHTVHPFRLAQEGLQTSNAFMGASRRIQVE-REDLVMMLNCTDPTQPPSTHELKKETQERCKELGVGSCILKYVDQ--------RFTLYTVGWRGTSSLRAYVQKDETIHILRLLGAD 674          

Query:  429 CGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML----TEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
             G    Q A S+LP + L  + + ++LD+C+APG K + +  ++        TGV+ AND    R   +V    RL     VV  +D + F  I               FDR+L D PC+G G + K+  +    S       + LQ K+L  +++      + GG +VYSTCS+ P E+E V+   L +    V+LV      TGL     G T+                        FR   F P    SLNL   +R  P   N  GF++A L+K S
Sbjct:  414 AGHYMIQGASSLLPVMALAPQENERILDMCSAPGGKGSHIASIMKN------TGVLFANDSNRDRIKAIVANFHRLGIVNAVVSCEDGTKFRNIM------------TGFDRVLLDAPCTGTGVVSKDPSVKTTKSEVDVQRCYNLQRKLLLTAIDCTDAKSSTGGYIVYSTCSVLPEENEWVIDYALKKR--NVKLVP-----TGLDFGVEGFTK------------------------FRQHRFHP----SLNL--TKRYYPHTHNMDGFYVAKLKKFS 639          

Query:  450 EAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQD---LWP-RWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAV----LAAILSQAQGTVRLVDISNRLTGLISE 1046
            +  S LPPL L ++   +VLD CA+PG K+  +++ LH          ++ NDI+  R    +++L+++    +   ++  +   R+ L  S +++      FD+IL DVPC+ D  +   QD     P R    L + E  LQ  IL   L +L  GG +VYSTCSL+PI+++ V    L  + ++   T  + D+S R T L S+
Sbjct:  276 DGASTLPPLFLQVKPGERVLDACASPGGKSLLMLQTLHLDH-------LVCNDIQESR----LNKLRKVMQEYLFDYKERWA-GKRLILSQSDARNLDQYEQFDKILVDVPCTTDRHVLNEQDNNIFKPTRIKERLRIPE--LQAGILANCLRLLRPGGSLVYSTCSLSPIQNDGVVHMALQKVFTEYGITTTIKDLS-RHTALFSD 467          

Query:  477 LLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPML----FDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTG 1034
            +LD +   ++LD+CAAPG+KT+ + E++    D+   G V+A D  + R   M+ +L   +S    V     ++      P +       P      FDRIL D PCSG G  R       +    L    H +Q ++  ++++++  GG +VYSTC++   E E ++A  L +    +RL D + R  G
Sbjct:  222 VLDPQPGERILDMCAAPGNKTSHIAELMG---DR---GSVVALDNSASRVRSMLPKLGHYKSITAHVFNSTEAVAADA--PSAPVGEFTGPPFPCESFDRILLDAPCSGLGN-RPQLSCSIKQVKVLSSYPH-IQRRLFEQAVQLVRPGGILVYSTCTVTEDECECLVAWALRKFV-ELRLTDATPRWGG 400          

Query:  477 LLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPML----FDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTG 1034
            +LD +   ++LD+CAAPG+KT+ + E++    D+   G V+A D  + R   M+ +L   +S    V     ++      P +       P      FDRIL D PCSG G  R       +    L    H +Q ++  ++++++  GG +VYSTC++   E E ++A  L +    +RL D + R  G
Sbjct:  141 VLDPQPGERILDMCAAPGNKTSHIAELMG---DR---GSVVALDNSASRVRSMLPKLGHYKSITAHVFNSTEAVAADA--PSAPVGEFTGPPFPCESFDRILLDAPCSGLGN-RPQLSCSIKQVKVLSSYPH-IQRRLFEQAVQLVRPGGILVYSTCTVTEDECECLVAWALRKFV-ELRLTDATPRWGG 319          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLN---LQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGES-GLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEK--SEPPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDVVAAARKDNGDRN 2171
            ++N L   YY+ +      ++ EF   MR  LPAT R+TG++  ++E+   +K K+ +++     ++ +   +  P  +P SWYPDE+AW  N S+  +RK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL IE  HK+LD+CAAPGSKTAQL+EMLH+  D   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+        +GK  +LF DRIL DVPCSGDGT+RKN D+W +W+    ++ H LQ++I  R +E L  GGRMVYSTCSLNPIEDEAV+AA+L +++G++ L D S  L GL    G+T WKVM K+  W S+  EVP +     R ++FPP+D + L    L+ C RILP +QNTGGFF+A+L K + +PW +       +   S  E    +E      P+++ P  G S   P EE                      +   P       E     PP KK ++  FKEDPF ++  DD  +  ++ FY++S +FP   ++ R  +GK+R+ Y  ++ L+ ++  NS+R +  +N GVK+   + D    G  +R+ QEGV  +  +I +  R++  +  D+  LLT + P +++         + L +G ++ +Y L +    + P+ P+   GWRG++S+R +V  +ER H LR+ G+E        R   G RN
Sbjct:   37 KENKLFEHYYQELKIVPDGEFEEFMEAMREPLPATIRITGYKSHAKEILHTLKEKYFKEV---QDLEVDGQKIEAP--QPLSWYPDELAWHTNLSRKILRKSPLLEKFHQFLVSETESGNISRQEAVSMIPPLLLKIEPQHKILDMCAAPGSKTAQLIEMLHSDMDVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLHF----DNNGKKDILFYDRILCDVPCSGDGTMRKNIDVWKKWTTSNSLHLHGLQLRIAVRGVEQLAVGGRMVYSTCSLNPIEDEAVIAALLEKSEGSLELADASPDLPGLKYMPGITSWKVMTKEGQWFSNFSEVPTSRHTQIRPTMFPPSDSEKLTEMRLERCVRILPHHQNTGGFFVAVLVKKAPMPWNRRHPKLRNKEVSSSGEVAPVEELQMDESPTDVPPADGPSTDAPVEE----------------GERNPSVPETPEPVEVKKENVCGPPPPKKMKLFGFKEDPFVFLTEDDPIFPPIQSFYDLSPDFPKLNVLTRTHEGKKRHLYMVSKELRNVLLNNSER-MKVINTGVKVLSRNNDGEQFGCAFRLAQEGVYTLCPYIRA--RIINISVEDVKVLLTQENPFLSKLGDEAHMQAKKLEMGSIVLRY-LPDPKDLDAPQCPIDLCGWRGKTSIRAFVSRNERLHYLRMVGVE------VFRDKQGKRN 711          

Query:  156 TMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLN---LQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGES-GLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEK--SEPPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDVVAAARKDNGDRN 2171
             MR  LPAT R+TG++  ++E+   +K K+ +++     ++ +   +  P  +P SWYPDE+AW  N S+  +RK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL IE  HK+LD+CAAPGSKTAQL+EMLH+  D   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+        +GK  +LF DRIL DVPCSGDGT+RKN D+W +W+    ++ H LQ++I  R +E L  GGRMVYSTCSLNPIEDEAV+AA+L +++G++ L D S  L GL    G+T WKVM K+  W S+  EVP +     R ++FPP+D + L    L+ C RILP +QNTGGFF+A+L K + +PW +       +   S  E    +E      P+++ P  G S   P EE                      +   P       E     PP KK ++  FKEDPF ++  DD  +  ++ FY++S +FP   ++ R  +GK+R+ Y  ++ L+ ++  NS+R +  +N GVK+   + D    G  +R+ QEGV  +  +I +  R++  +  D+  LLT + P +++         + L +G ++ +Y L +    + P+ P+   GWRG++S+R +V  +ER H LR+ G+E        R   G RN
Sbjct:    3 AMREPLPATIRITGYKSHAKEILHTLKEKYFKEV---QDLEVDGQKIEAP--QPLSWYPDELAWHTNLSRKILRKSPLLEKFHQFLVSETESGNISRQEAVSMIPPLLLKIEPQHKILDMCAAPGSKTAQLIEMLHSDMDVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLHF----DNNGKKDILFYDRILCDVPCSGDGTMRKNIDVWKKWTTSNSLHLHGLQLRIAVRGVEQLAVGGRMVYSTCSLNPIEDEAVIAALLEKSEGSLELADASPDLPGLKYMPGITSWKVMTKEGQWFSNFSEVPTSRHTQIRPTMFPPSDSEKLTEMRLERCVRILPHHQNTGGFFVAVLVKKAPMPWNRRHPKLRNKEVSSSGEVAPVEELQMDESPTDVPPADGPSTDAPVEE----------------GERNPSVPETPEPVEVKKENVCGPPPPKKMKLFGFKEDPFVFLTEDDPIFPPIQSFYDLSPDFPKLNVLTRTHEGKKRHLYMVSKELRNVLLNNSER-MKVINTGVKVLSRNNDGEQFGCAFRLAQEGVYTLCPYIRA--RIINISVEDVKVLLTQENPFLSKLGDEAHMQAKKLEMGSIVLRY-LPDPKDLDAPQCPIDLCGWRGKTSIRAFVSRNERLHYLRMVGVE------VFRDKQGKRN 651          

Query:  429 CGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSE 1346
             G    Q A S LP + L  +    VLD+ AAPG KT  + +++        TG+++AND    R   +V  + RL     V+   D   FP++         G     FDR+L D PCSG G + K+  +         +    LQ +++  +++ +      GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G TR                        F+   F P+      L+  RR  P + N  GFF+A L+K+S      P K  E + +   MET AS E  E
Sbjct:  361 AGHYMLQGASSFLPVMALSPQEGESVLDMSAAPGGKTTYMAQLMRN------TGMIVANDANVDRLKSVVGNIHRLGVTNAVICNYDGRQFPKVM-------GG-----FDRVLLDAPCSGTGVISKDPAVKTGKDEADILRSAHLQKELILSAIDSVNADSQTGGYLVYCTCSIMVEENEWVVDYALKKR--NVKLVP-----TGLDFGKEGFTR------------------------FKEKRFHPS------LKLSRRFYPHSHNMDGFFVAKLKKLSNTIPTAP-KETENQEESLVMETAASSEMKE 615          

Query:  450 EAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLP---------DSQSKSGKSPMLFDRILADVPCSGD--GTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQ 992
            +A S+LP L LD+     VLDLCAAPG KT  L++  H+         + AND+   R   +   LQ              S  P+ FL          D +    +    FDR+L DVPC+ D    + +  +++ R           LQ+++L   ++   +GG +VYSTCSL+ +++E V+   +S AQ
Sbjct:  168 DAASVLPVLALDVRPGQTVLDLCAAPGGKTLALLQA-HS------VNHLWANDLSVSRTGRLRKILQ--------------SYVPKEFLDEENIHITCIDGRELGMREEKSFDRVLVDVPCTTDRHSAVVEENNIFKRSRTKERQKLPLLQIQLLVAGIQAARQGGLIVYSTCSLSQLQNECVVQQAISVAQ 338          

Query:  453 AVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQD-----LWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGT 998
            A S+LP L L+++    VLDLCAAPG K+   + +L   T     G++  N+++  R   ++  L+    P +   R   S    + L D +S     P  +D++L D PCS D +     D     +W +    L +    LQ ++L  +L  +  GG +VYSTC+++  E+++V+  +L+   G 
Sbjct:  157 AASLLPVLALNVQEGENVLDLCAAPGGKS---LAILQTATP----GLLHCNEVDQHRHDWLLKTLESYVPPSL---RHLLS----VTLQDGRSIGTMQPGAYDKVLVDAPCSNDRSWLYTPDTHRGEMWLKERTQLPL----LQKELLCSALAAVRPGGIVVYSTCTMSRAENQSVVEEVLASYPGV 325          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----PPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL++ET+ G ISRQEAVSM+PP+LL ++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGTLRKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+A++L +++G++ L D+++ + GL    G+T+WKVM K+  W    +++P +     R ++FPP D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K  +  + + +P     V++ + S    P  +K V   S   ++E  ++ ++                  +P    ++S K++     PP KK ++  FKEDPF ++  DD  +D ++ FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R+V  +  D+  LLT + P +++FS+  Q+      +G ++ +Y+    + E + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   35 KENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKEL---QDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREV---LYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNK--RQPKLQRRPP----VSACDASIAVAPELVKAVTENSAGMADEPAVDTENG---------------ETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINA--RIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETL-QCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVE 696          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----PPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL++ET+ G ISRQEAVSM+PP+LL ++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGTLRKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+A++L +++G++ L D+++ + GL    G+T+WKVM K+  W    +++P +     R ++FPP D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K  +  + + +P     V++ + S    P  +K V   S   ++E  ++ ++                  +P    ++S K++     PP KK ++  FKEDPF ++  DD  +D ++ FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R+V  +  D+  LLT + P +++FS+  Q+      +G ++ +Y+    + E + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   21 KENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKEL---QDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREV---LYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNK--RQPKLQRRPP----VSACDASIAVAPELVKAVTENSAGMADEPAVDTENG---------------ETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINA--RIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETL-QCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVE 682          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----PPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL++ET+ G ISRQEAVSM+PP+LL ++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGTLRKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+A++L +++G++ L D+++ + GL    G+T+WKVM K+  W    +++P +     R ++FPP D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K  +  + + +P     V++ + S    P  +K V   S   ++E  ++ ++                  +P    ++S K++     PP KK ++  FKEDPF ++  DD  +D ++ FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R+V  +  D+  LLT + P +++FS+  Q+      +G ++ +Y+    + E + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   22 KENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKEL---QDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREV---LYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNK--RQPKLQRRPP----VSACDASIAVAPELVKAVTENSAGMADEPAVDTENG---------------ETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINA--RIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETL-QCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVE 683          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----PPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL++ET+ G ISRQEAVSM+PP+LL ++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGTLRKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+A++L +++G++ L D+++ + GL    G+T+WKVM K+  W    +++P +     R ++FPP D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K  +  + + +P     V++ + S    P  +K V   S   ++E  ++ ++                  +P    ++S K++     PP KK ++  FKEDPF ++  DD  +D ++ FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R+V  +  D+  LLT + P +++FS+  Q+      +G ++ +Y+    + E + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   25 KENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKEL---QDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREV---LYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNK--RQPKLQRRPP----VSACDASIAVAPELVKAVTENSAGMADEPAVDTENG---------------ETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINA--RIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETL-QCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVE 686          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----PPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL++ET+ G ISRQEAVSM+PP+LL ++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGTLRKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+A++L +++G++ L D+++ + GL    G+T+WKVM K+  W    +++P +     R ++FPP D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K  +  + + +P     V++ + S    P  +K V   S   ++E  ++ ++                  +P    ++S K++     PP KK ++  FKEDPF ++  DD  +D ++ FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R+V  +  D+  LLT + P +++FS+  Q+      +G ++ +Y+    + E + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   37 KENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKEL---QDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREV---LYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNK--RQPKLQRRPP----VSACDASIAVAPELVKAVTENSAGMADEPAVDTENG---------------ETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINA--RIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETL-QCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVE 698          

Query:   27 KKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSL---NLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----------PPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            +KR   G    Y  E  ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +KNK+ ++L     ++ +   V  P  +P SWYP+E+AW  N S+  +RK+P L K H FL+SET+ G ISRQEAVSM+PPLLL++E HHK+LD+CAAPGSKT QL+EMLHA      P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNP+EDEAV+AA+L +++G + L D+S  L GL    G+++WKVM +D  W +   EVP       R ++FPP D++ L   +L+ C RILP +QNTGGFF+A+L K + +PW K         QP         +++E  +P     V    G PS++  +E +                     S T  N+E +E           PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+ TLLT + P   + S       + L+ G V+ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   27 RKRGQAGWEGGY-PEIVKENKLFEHYYQELKIVPEGEWDQFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKEL---EDLEVDGQKVEVP--QPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTV----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNK--------RQPK-----VQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGD--------------SETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKTLLTQENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 704          

Query:  156 TMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSL---NLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----------PPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++R  LPAT R+TG++  ++E+   +KNK+ ++L     ++ +   V  P  +P SWYP+E+AW  N S+  +RK+P L K H FL+SET+ G ISRQEAVSM+PPLLL++E HHK+LD+CAAPGSKT QL+EMLHA      P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNP+EDEAV+AA+L +++G + L D+S  L GL    G+++WKVM +D  W +   EVP       R ++FPP D++ L   +L+ C RILP +QNTGGFF+A+L K + +PW K         QP         +++E  +P     V    G PS++  +E +                     S T  N+E +E           PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+ TLLT + P   + S       + L+ G V+ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:    3 SLREPLPATLRITGYKSHAKEILHCLKNKYFKEL---EDLEVDGQKVEVP--QPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTV----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNK--------RQPK-----VQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGD--------------SETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKTLLTQENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 638          

Query:   27 KKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSL---NLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----------PPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            +KR   G    Y  E  ++N L   YY+ +      +W++F  ++R  LPAT R+TG+++                                        YP+E+AW  N S+  +RK+P L K H FL+SET+ G ISRQEAVSM+PPLLL++E HHK+LD+CAAPGSKT QL+EMLHA      P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNP+EDEAV+AA+L +++G + L D+S  L GL    G+++WKVM +D  W +   EVP       R ++FPP D++ L   +L+ C RILP +QNTGGFF+A+L K + +PW K         QP         +++E  +P     V    G PS++  +E +                     S T  N+E +E           PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+ TLLT + P   + S       + L+ G V+ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   27 RKRGQAGWEGGY-PEIVKENKLFEHYYQELKIVPEGEWDQFMESLREPLPATLRITGYKR----------------------------------------YPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTV----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNK--------RQPK-----VQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGD--------------SETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKTLLTQENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 669          

Query:  360 SKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEH--------FLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
            S + I  TPE    H  L           Q A SMLP + L  + H ++LD+C APG KT+ + +++        TGV++AND  + R   +V  L RL     ++   D   FP++               FDR+L D PCSG G + K+        P +  N+          LQ ++L  +++ +      GG +VY TCS+   E+E V+   L +    VRLV      TGL   + G TR                        F++  F P       L+  RR  P   N  GFFIA  +K S
Sbjct:  336 SSVPIGATPEYLAGHYML-----------QGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKN------TGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVV------------GGFDRVLLDAPCSGTGVISKD--------PAVKTNKDEKDIQRCAHLQKELLLSAIDSVNAASKTGGYLVYCTCSITVEENEWVVDYALKKR--NVRLVP-----TGLDFGQEGFTR------------------------FQARRFHP------TLRSTRRFYPHTHNMDGFFIAKFKKFS 573          

Query:  453 AVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQR-LQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGT-LRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISN 1022
            A S+LP L L++     VLDLCAAPG K+  L++  +        G ++ N+ +  R   +   L+  +  P I V+        ++   D +      P  FD++L D PCS D + L  +      +      N   LQ++++R +++ L  GG +VYSTC+L+  E++ V++ +L+     V  VDIS 
Sbjct:  118 AASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYP-------GYLLCNEYDRPRGRWLRQTLESFIPQPLINVI--------KVSELDGREMGDAQPATFDKVLVDAPCSNDRSWLFSSDSQKAAYRIHQRKNLPVLQVELVRSAIKALRPGGLLVYSTCTLSKAENQDVISEVLTSDSNIVP-VDISG 293          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----PPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL++ET+ G ISRQEAVSM+PP+LL ++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGTLRKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+A++L +++G++ L D+++ + GL    G+T+WKVM K+  W    +++P +     R ++FPP D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K  +  + + +P     V++ + S    P  +K V   S   ++E  ++ ++                  +P    ++S K++     PP KK ++  FKEDPF ++  DD  +D ++ FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R+V  +  D+  LLT + P +++FS+  Q+      +G ++ +Y+    + E + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   45 KENKLFEHYYQELKIVPDGEWDKFMASLREPLPATIRITGYKSHAKEILHCLKEKYFKEL---QDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVNETESGNISRQEAVSMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLVENNGSREV---LYYDRILCDVPCSGDGTLRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVASEIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNK--RQPKLQRRPP----VSACDASIAVAPELVKAVTENSAGMADEPAVDTENG---------------ETKPCTNQSDSSKTDIVCCPPPSKKMKLFGFKEDPFVFVSEDDPIFDPIQTFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYTLYPFINA--RIVTVSIEDIKVLLTQENPFLSKFSKETQKQANNFDMGSIVLKYEPDPQEPETL-QCPIVLCGWRGKTSIRSFVPKNERLHYLRMMGVE 706          

Query:   27 KKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSL---NLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSE-----------PPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            +KR   G    Y  E  ++N L   YY+ +      +W++F  ++R  LPAT R+TG++  ++E+   +KNK+ ++L     ++ +   V  P  +P SWYP+E+AW  N S+  +RK+P L K H FL+SET+ G ISRQEAVSM+PPLLL++E HHK+LD+CAAPGSKT QL+EMLHA      P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNP+EDEAV+AA+L +++G + L D+S  L GL    G+++WKVM +D  W +   EVP       R ++FPP D++ L   +L+ C RILP +QNTGGFF+A+L K + +PW K         QP         +++E  +P     V    G PS++  +E +                     S T  N+E +E           PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+ TLLT + P   + S       + L+ G V+ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   27 RKRGQAGWEGGY-PEIVKENKLFEHYYQELKIVPEGEWDQFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKEL---EDLEVDGQKVEVP--QPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTV----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNK--------RQPK-----VQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGD--------------SETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKTLLTQENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 704          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLF-DRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMK--PSKSGEK-ESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLF--GISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L   YY+ +      +W +F   +R  LPAT R+TG++  ++E+   +KNK+ ++L     ++ +   V  P  +P SWYP+E+AW  N S+  +RK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL++  HHK+LD+CAAPGSKT QL+EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +       G+  +LF DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R  E L EGGRMVYSTCSLNPIEDEAV+A++L +++G + L D+SN L GL    G+T+WKVM KD  W +  D VP +     R ++FPP D   + +++L+ C RILP +QNTGGFF+A+L K S +PW K  P   G+  E++ S   + A     + +DPS+++  P  +G    E                    +   +  + +  +     PP KK ++F  KEDPF +I  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++    S +     +R+ QEG+  +  FI S  R++  +  D+  LLT + P   + S       + L+ G ++ +Y+  + + + + + P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   43 KENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKEL---EDLEVDGQKVEVP--QPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQI----DVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLE-SPSFTGTGDTE-----------------IAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINS--RIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDAL-QCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLE 705          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMK---------PSKSGEKESQPSPMETVA-----SQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLR 2108
            ++N L   YY+ +      +W++F   +R  LPAT R+TG++  ++E+   +K K+ ++L     I+ +   +  P  +P SWYP+E+AW  N S+  IRK+PEL+K H FL+SET+ G ISRQEAVSM+PP+LL+++ HHK+LD+CAAPGSKTAQ++EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ + ++ S+     + +DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNP+EDEAV+ ++L +++G++ L D+++ L GL    G+T+W+VM K+  W    ++VP +     R ++FP  D   + S+NL  C RILP +QNTGGFF+A+L K + +PW K         P    +    P  ++ VA     + E +  ++  E KP   +SG                                 ++ T+S    PP KK ++F  KEDPF ++  DD  ++ +++FY +   FP + L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K+   + D    G  YR+ QEG+  +  FI +  R++  +  D+  LLT + P +++FS+  Q+    L +G ++ +Y+      E + + P+   GWRG++S+R +V    R +L++
Sbjct:   41 KENKLFEHYYQELKIVPDGEWDKFMDALREPLPATIRITGYKSHAKEILHCLKEKYFKEL---PDIEVDGQKIEAP--QPLSWYPEELAWHTNLSRKIIRKSPELEKFHQFLVSETESGNISRQEAVSMIPPVLLNVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPRLLIENNGSREV---LYYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIVSLLDKSEGSLELADVASELPGLKWMPGITQWRVMTKEGQWFEKWEDVPTSRHTQIRPTMFPLKDEEKLKSMNLNRCMRILPHHQNTGGFFVAVLIKKAPMPWNKRQPKLQRRPPVSVCDASVAPEIVKAVADISAIADEPAVDAENGETKPCTNQSG---------------------------------SSKTDSVCCPPPSKKMKLFGFKEDPFVFLSEDDPIFEPIQKFYALDPSFPKKNLLTRTQEGKKRQLYMVSKELRNVLLHNSEK-MKVINTGIKVLCRNNDGEQYGCAYRLAQEGIYSLYPFINA--RILTVSVEDIKVLLTQENPFLSKFSKETQKQANNLDMGSIVLKYEPDPQQPETL-QCPIVLCGWRGKTSIRSFVFFLHRINLVQ 694          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMET----VASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKS---EPPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDVVAAARKD 2156
            ++N+L   YY+        +W+ F   +R  LPAT R+TG++  +RE+   +K K+  +L     ++ +   V  P A   SWYP+E+AW  N S+  +RK+P+L++ H FL+SET+CG ISRQEAVSM+PPLLL++   HK+LD+CAAPGSKTAQL+EMLHA  +   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  P + +        K  + +DRIL DVPCSGDGT+RKN D+W +W+    +  H LQ++I  R +E L EGGRMVYSTCSLNPIE+EAV+A++L ++QG + L D+S+ L GL    G+T+WKVM+KD  W     +VP   +   R ++FP  +   + ++NL+ C RILP +QNTGGFF+A+L K S +PW   +K   K  Q  P +T    V +    + S+ +  KP   E   P                        +++   ++    S+K     PP KK ++F  KEDPF ++  DD  +  +++FY +   FP   L+ R  +GK+R  Y  ++ L+ ++  NS++ +  +N G+K++  + D    G  +R+ QEG+  +  FI +  R+V     D+  LLT + P +++FS   Q+  + +++G ++ +Y+   +  +++ + P+   GW+G++SLR +V  +ER H LR+ G   V+V  A RK+
Sbjct:   43 KENELFERYYREQRIVPDGEWDAFMAALREPLPATLRITGYKSHAREILHCLKEKYFREL---QHLEVDGQKVEMPQA--LSWYPEELAWHTNLSRKILRKSPQLERFHQFLVSETECGNISRQEAVSMIPPLLLNVNPDHKILDMCAAPGSKTAQLIEMLHADMNVPFPKGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASSIPNLQV---DVDGRKETLFYDRILCDVPCSGDGTMRKNIDVWKKWTTQNSLQLHGLQLRIATRGVEQLAEGGRMVYSTCSLNPIENEAVIASLLEKSQGALELADVSSELPGLKRMPGITKWKVMLKDGQWFEEWKDVPSNRQTQIRPTMFPIKEEEKLKAMNLERCIRILPHHQNTGGFFVAVLIKKSPMPW---NKRQPKVHQKLPGKTEDTEVTATNAGDGSEDATEKPTLAEDEEPK-----------------------KVQELQNSDTEQSKKGVCGPPPSKKMKLFGFKEDPFVFLPEDDPLFLPIQKFYALDPSFPKMNLLTRTQEGKKRQLYMVSKELRNVLLNNSEK-MKVINTGIKVWSRNSDGEQFGCAFRLAQEGIYTLYPFIHA--RIVNVCIEDVKILLTQENPFLSKFSSETQRKVKDMAMGSIVLKYEPDPEKPDDL-QCPIVLCGWQGKTSLRAFVPKNERLHYLRMMG---VEVFKAKRKE 709          

Query:    3 YINLI*MVKKRHNRGRANKYLNEED-RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLA-KPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKI--------------PTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGK----SPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML----TEG---GRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL------------ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKP-DDKAWDGLKQFYEISE-------------EFPNQQLMYRNA--DGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFI----GSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIP---LRFAGWRGRSSLRHYVGVHERSHLLRLCGMEP 2126
            Y+  +  V  RH R R   +   ED ++N L  EYY+G    +  +W +F   ++ +LP TFRVTGFR+Q++E+  LIK ++ E++       + +      +A K   WYPDE+AWQL+ ++  +RKTPELK LH FL+SE + G ISRQEAVSMLPPL+LD+ S+H VLDLCAAPGSK+AQLVE+LHA  +                PTG+VIAND++ KRCYMMVHQ++RLQSPC ++ ++DA+ FP++++P S ++  +       LFDR+LADVPCSGDGTLRKN DLW RW+P LG++EH+LQ++ILRR LE+L    ++G   GR+VYSTCS NP+E+EAV+A +L   QG+VRLV+  ++L  +            +   GLT+W+VM K   W    ++VP +   + R SLFPP DV  L+L+ C RI+P +QNTGGFF+A+LEK++ LPWMK ++            T  +   +  S+P      PG   +   E+                 D +Q   RP    TN+ K EP  KK R+F E+PF YI P  D  W G++ +Y ISE              FP   L+YR+   + +RR +Y+TN L K+++E+NS R +  V+ GV+LF I ED+ FNGYR+LQ+GV++ + F+    G   RL  +  SDL+ LL  +MPLI+  + S Q  +  ++ GPV+ +Y   +D     P +P   L FAGWRG  SLRHY+G HER HL+RL  +EP
Sbjct:    8 YVFFVSQVMGRHGRPRVGHHCFTEDTKRNALFEEYYQGQCIVSESEWPDFMCHLQQDLPITFRVTGFREQNKELLRLIKCRYREEISQITFPSSEDGKSHNHIAFKALPWYPDELAWQLDTNRFVVRKTPELKILHQFLVSEMESGNISRQEAVSMLPPLVLDVRSYHAVLDLCAAPGSKSAQLVELLHADAESQCVTAVANEVWPYSEPTGMVIANDVDQKRCYMMVHQVKRLQSPCTMITQEDATCFPKLYVPQSSTEKDQLTVNEQFLFDRVLADVPCSGDGTLRKNPDLWLRWNPNLGISEHYLQLRILRRGLELLRDRCSDGQDYGRLVYSTCSFNPLENEAVVANMLHACQGSVRLVE-PDKLPSVTLFKTEAEPNRFVVRPGLTKWRVMNKKGCWFDKFEDVPPSQHSNIRPSLFPPEDVSKLHLERCMRIVPHDQNTGGFFLAVLEKIAPLPWMKQARG-----------TFMATGAAMASEPGVSTGNPGLGEIAVSEK---------------SADLNQPGKRPHDPQTNTNKEEP--KKPRVFNENPFTYIDPVGDTEWHGIRDYYGISEMLHPDDFSPPSDRRFPPSHLLYRSTKEELRRRQFYYTNGLTKRIIESNSARGLKIVSSGVRLFSIMEDKQFNGYRLLQDGVDLADAFLPARGGRRIRLTAAEYSDLVLLLQEEMPLISRMTSSTQAQWSAMNPGPVLIEYCPSSDGEPIDPNLPQCRLIFAGWRGVKSLRHYIGRHERLHLMRLANLEP 748          

Query:   33 RHNRGRANKYLNEED-RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLA-KPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKI--------------PTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPM----LFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEG-------GRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLV--DISNRLTGLISES---------GLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKP-DDKAWDGLKQFYEISE-------------EFPNQQLMYRNA--DGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFI----GSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDD---SEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEP 2126
            RH R R  ++   ED ++N L  EYY+G    +  +W  F   ++ +LP TFRVTGFR+Q++E+  LIK ++ E++       + +      +A K   WYPDE+AWQL+ ++  +RKTPELK LH FL+SE + G ISRQEAVSMLPPL+LD+ S+H VLDLCAAPGSK+AQLVE+LHA  +                PTG+VIAND++ KRCYMMVHQ++RLQSPC ++ ++DA+ FP++++P S ++  ++ +    LFDR+LADVPCSGDGTLRKN DLW RW+P LG++EH+LQ++ILRR LE+L +        GR+VYSTCS NP+E+EAV+A +L   QG+VRLV  D    +T   +E+         GLT+W+VM K   W    ++VP +   + R SLFPP DV  L+L+ C RI+P +QNTGGFF+A+LEK++ LPWMK ++             VA+    E    SE+    G  G              +    EK  D +Q   RP    TN+ K EP  KK R+F E+PF YI P  D  W G++ +Y ISE              FP   L+YR+   + +RR +Y+TN L+K+++E+NS R +  V+ GV+LF I ED+ FNGYR+LQ+GV++ + F+    G   RL  +   DL+ LL  +MPLI+  + S Q  + +++ GPV+ +Y   +D       +P+  L FAGWRG  SLRHY+G HER HL+RL  +EP
Sbjct:    3 RHGRPRVGRHCFTEDTKRNALFEEYYQGQCIVSESEWPAFMYHLQQDLPITFRVTGFREQNKELLRLIKYRYREEISQITFPSSEDGQSHKHIAFKALPWYPDELAWQLDTNRFVVRKTPELKVLHQFLVSEMESGNISRQEAVSMLPPLVLDVRSYHAVLDLCAAPGSKSAQLVELLHADAESQCITEVANEVWPYSEPTGMVIANDVDQKRCYMMVHQVKRLQSPCTMITQEDATCFPKLYVPQSSTEKDQTTVNEQFLFDRVLADVPCSGDGTLRKNPDLWLRWNPNLGISEHYLQLRILRRGLELLRDHCANGQDYGRLVYSTCSFNPLENEAVVANMLHACQGSVRLVEPDKLPSVTLFKTEAEPNRFLVRPGLTKWRVMNKKGCWFDKFEDVPPSQHSNIRPSLFPPEDVSELHLERCMRIVPHDQNTGGFFLAVLEKIAPLPWMKQARR----------TFVATDAAVE----SELGVSAGNPGF------------GEITVSEKSADPNQSGKRPHDPQTNTNKEEP--KKPRVFSENPFTYIDPVGDTEWHGIRDYYGISEMLHPDDFSPPSDRRFPPSHLLYRSTKEELRRRQFYYTNGLIKRIIESNSARGLKIVSSGVRLFSIMEDKQFNGYRLLQDGVDLADAFLPARGGRRIRLTAAEYPDLVLLLQEEMPLISRMTSSTQAQWSVMNPGPVLIEYCPSSDGEPLDSNLPQCRLVFAGWRGVKSLRHYIGRHERLHLMRLANLEP 733          

Query:    3 YINLI*MVKKRHNRGRANKYLNEED-RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLA-KPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKI--------------PTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGK----SPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML----TEG---GRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL------------ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKP-DDKAWDGLKQFYEISE-------------EFPNQQLMYRNA--DGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFI----GSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIP---LRFAGWRGRSSLRHYVGVHERSHLLRLCGMEP 2126
            Y+  +  V  RH R R   +   ED ++N L  EYY+G    +  +W +F   ++ +LP TFRVTGFR+Q++E+  LIK ++ E++       + +      +A K   WYPDE+AWQL+ ++  +RKTPELK LH FL+SE + G ISRQEAVSMLPPL+LD+ S+H VLDLCAAPGSK+AQLVE+LHA  +                PTG+VIAND++ KRCYMMVHQ++RLQSPC ++ ++DA+ FP++++P S ++  +       LFDR+LADVPCSGDGTLRKN DLW RW+P LG++EH+LQ++ILRR LE+L    ++G   GR+VYSTCS NP+E+EAV+A +L   QG+VRLV+  ++L  +            +   GLT+W+VM K   W    ++VP +   + R SLFPP DV  L+L+ C RI+P +QNTGGFF+A+LEK++ LPWMK ++        + M T A+           M   PG S  P                                  TN+ K EP  KK R+F E+PF YI P  D  W G++ +Y ISE              FP   L+YR+   + +RR +Y+TN L K+++E+NS R +  V+ GV+LF I ED+ FNGYR+LQ+GV++ + F+    G   RL  +  SDL+ LL  +MPLI+  + S Q  +  ++ GPV+ +Y   +D     P +P   L FAGWRG  SLRHY+G HER HL+RL  +EP
Sbjct:    8 YVFFVSQVMGRHGRPRVGHHCFTEDTKRNALFEEYYQGQCIVSESEWPDFMCHLQQDLPITFRVTGFREQNKELLRLIKCRYREEISQITFPSSEDGKSHNHIAFKALPWYPDELAWQLDTNRFVVRKTPELKILHQFLVSEMESGNISRQEAVSMLPPLVLDVRSYHAVLDLCAAPGSKSAQLVELLHADAESQCVTAVANEVWPYSEPTGMVIANDVDQKRCYMMVHQVKRLQSPCTMITQEDATCFPKLYVPQSSTEKDQLTVNEQFLFDRVLADVPCSGDGTLRKNPDLWLRWNPNLGISEHYLQLRILRRGLELLRDRCSDGQDYGRLVYSTCSFNPLENEAVVANMLHACQGSVRLVE-PDKLPSVTLFKTEAEPNRFVVRPGLTKWRVMNKKGCWFDKFEDVPPSQHSNIRPSLFPPEDVSKLHLERCMRIVPHDQNTGGFFLAVLEKIAPLPWMKQARG-------TFMATGAA-----------MASEPGVSTDPQ---------------------------------TNTNKEEP--KKPRVFNENPFTYIDPVGDTEWHGIRDYYGISEMLHPDDFSPPSDRRFPPSHLLYRSTKEELRRRQFYYTNGLTKRIIESNSARGLKIVSSGVRLFSIMEDKQFNGYRLLQDGVDLADAFLPARGGRRIRLTAAEYSDLVLLLQEEMPLISRMTSSTQAQWSAMNPGPVLIEYCPSSDGEPIDPNLPQCRLIFAGWRGVKSLRHYIGRHERLHLMRLANLEP 723          

Query:   33 RHNRGRANKYLNEED-RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLE---QLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKI--------------PTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPM----LFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML-------TEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVD-----------ISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKP-DDKAWDGLKQFYEISE-------------EFPNQQLMYRNA--DGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFI----GSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIP---LRFAGWRGRSSLRHYVGVHERSHLLRLCGMEP 2126
            RH R R  +    ED ++N L  EYY+G    +  +W +F   ++ +LP TFRVTGFR+Q++E+  LIK ++ E   Q+I  +  D      +    K   WYPDE+AWQL+  +  +RKTPELK LH FL+SE + G ISRQEAVSMLPPL+LD+ S+H VLDLCAAPGSK+AQLVE+LHA  +                PTG+V+AND++ KRCYMMVHQ++RLQSPC ++ ++DA+ FP++++P S ++  ++ +    LFDR+LADVPCSGDGTLRKN DLW RW+P LG++EH+LQ +ILRR LE+L        + GR+VYSTCS NP+E+EAV+A +L   QG+VRLV+            +      +   GLT+W+VM K   W    +EVP +   + R SLFPP DV  L+L+ C RI+P +QNTGGFF+A+LEK++ LPWMK ++            T  + + +  S+P      PG   +   E                  D +Q   RP    TN+ + EP  KK R+F E+PF YI P  D  W G++ +Y I+E              FP   L+YR+   + +RR +Y+TN L+K+++E+NS R +  V+ GV+LF I ED+ FNGYR+LQ+GV++ + F+    G   RL  +   DL+ LL  +MPLI+  + S Q  +  ++ GPV+ +Y   +      P +P   L FAGWRG  SLRHY+G HER HL+RL  +EP
Sbjct:    3 RHGRPRVGRRCFTEDTKRNALFEEYYRGQSIVSESEWPDFMYHLQQDLPITFRVTGFREQNKELLRLIKYRYREEISQIIFPSSEDGQSH--NHITFKALPWYPDELAWQLDTDRFVVRKTPELKVLHQFLVSEMESGNISRQEAVSMLPPLVLDVRSYHAVLDLCAAPGSKSAQLVELLHADAESQCVTEVSNDAWPYSEPTGMVVANDVDQKRCYMMVHQVKRLQSPCTMITQEDATCFPKLYVPQSSTEKDQTTVNEQFLFDRVLADVPCSGDGTLRKNPDLWLRWNPNLGISEHYLQSRILRRGLELLRDRCADGQDYGRLVYSTCSFNPLENEAVVANMLHACQGSVRLVEPDKLPFVTLLKTAADPNRFLVRPGLTKWRVMNKKGCWFDKFEEVPPSQHSNIRPSLFPPEDVSELHLERCMRIVPHDQNTGGFFLAVLEKIAPLPWMKQAR-----------RTFVATDVAVESEPGVSAGYPGLGDIAVFEN---------------SADPNQPGKRPHDPQTNANQEEP--KKPRVFNENPFTYIDPVRDTEWHGIRDYYGIAEMLHPDDSSPPSNRRFPPSHLLYRSTKEELRRRQFYYTNGLIKRIIESNSARGLKIVSSGVRLFSIMEDKQFNGYRLLQDGVDLADAFLPPHGGRRIRLTAAEYPDLVLLLQEEMPLISRMTSSTQAQWSAMNPGPVLIEYCPSSGCEPTDPNLPHCRLIFAGWRGVKSLRHYIGRHERLHLMRLANLEP 733          

Query:   21 MVKKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKN--KIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKI---------PTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPD-SQSKSGKSPM---LFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEG------GRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLI------------SESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKP-DDKAWDGLKQFYEISE---------------EFPNQQLMYRNADG--KRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFIGSV--RRLVLS--TRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSE---EMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEP 2126
            MV+KR  R   +++   E R+N    +YYKG       +W  F   ++ ELP TFRVTGFR+Q+RE+  LIK+++  ++I       D+ E           SWYP+E+AWQL+AS+  +RKTPELK LH+FL+SET+ G ISRQEAVSMLPPLLLDI S+H VLDLCAAPGSK+AQLVE+LHA  +           PTG+V+AND++ KRCYMMVHQ++RLQSPC V+ ++DA+ FPR+++PD S  K+ K  M   LFDR+LADVPCSGDGTLRKN DLW RWSP LG+ EH+LQ++ILRR LE+L +       GR+VYSTCS NP+E+EAV+A++L   QG VRLV   +RL  +             +  GLT W+VM K   W    ++VP + + + R SLFPP ++  L L  C R+ PQ+QNTGGFF+A+LEKV+ LPWMKP+           +  +  QE +E  D S++     E+  P E                              T  N   S    KK R+F E+PF YI P DDK W  ++ +Y I E                F    L+YR+     +RR +Y+TN+L KQ++++N  R I  VN GV++F I ED+ F GYR+LQ+GV++ + F+     RR+ L+    SDL  LL  +MPLI+  + + Q  +  L+ GPV+  Y   N + E    +P+  L FAGWRG  SLRHY+G HER HL+RL  ++P
Sbjct:    1 MVRKRRPRVGHHQF-TPETRQNFQFEQYYKGQGLIVDSEWPAFMHALQQELPVTFRVTGFREQNRELLRLIKHRYRNEIIKLQFPATDSGEVQQQHISFDSLSWYPNELAWQLDASRFVVRKTPELKVLHHFLVSETESGNISRQEAVSMLPPLLLDIRSYHSVLDLCAAPGSKSAQLVELLHADAETKRTADWSYTEPTGLVVANDVDQKRCYMMVHQVKRLQSPCTVITQEDATCFPRLYVPDPSTLKTDKVEMTQFLFDRVLADVPCSGDGTLRKNPDLWLRWSPNLGIAEHYLQLRILRRGLELLRDTTSDGDHGRLVYSTCSFNPLENEAVIASMLHACQGAVRLVG-PDRLACVTRRGPDASRGRFQTRPGLTSWRVMNKKGCWFDKFEDVPQSQQCNLRPSLFPPPNITELGLDRCFRVFPQDQNTGGFFLAVLEKVAPLPWMKPTGPRSYTFVGPIVSGICDQEEAE--DASDLI----ETDFPPEPN--------------------------KQTCENECSSAIESKKPRVFNENPFTYIDPSDDKDWANIRDYYGIMETSDHDAVDPKNGVIRNFCPANLLYRSTGDELRRRQFYYTNKLAKQIIQSNLCRGIKIVNCGVRMFCIMEDKQFTGYRLLQDGVDLADAFLPETGGRRIHLTWMQYSDLKLLLEEEMPLISRMTMTTQSQWNRLTPGPVLIDYSPSNTEVETEQNLPQCRLVFAGWRGIQSLRHYIGRHERLHLMRLANLDP 726          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQY--DLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            ++N L  +YY+ +      ++ EF   MR  LPAT R+TG++  ++E+   +K K+ +  I   +ID  +  +  P A   SWYPDE AW  N S+  +RK+P L+K H FL+SET+CG ISRQEAVSM+PPLLL IE HHK+LD+CAAPGSKTAQL+EMLH+  D   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +   +    K  + +DR+L DVPCSGDGT+RKN D+W +W+    ++ H LQ++I  R +E L  GGRMVYSTCSLNPIEDEAV+A++L +++G + LVD S  L GL    G+T WK+M K+  W S   EVP       R ++FPP D   + S+ L+ C RILP +QNTGGFF+A+L K   +PW +         QP      A+  T++   P E     G+   PSEE      +                   P A   +     PP KK ++  FKEDPF ++  DD  +  ++ FY +S +FP   ++ R  +GK+R+ Y  ++ L+ ++  NS+R +  +N GVK++  + D    G  +R+ QEG+  +  +I +  R++  +  D+  LLT + P ++   +      + L +G ++ +Y  DL++ D+   P+ P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   38 KENKLFEQYYQELKIVPEGEFEEFMEAMREPLPATIRITGYKSHAKEILHTLKEKYFKD-IQDLEIDGQK--IEAPQA--LSWYPDEQAWHTNMSRKILRKSPLLEKFHQFLVSETECGNISRQEAVSMIPPLLLKIEPHHKILDMCAAPGSKTAQLIEMLHSDMDVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASCIPRLMV---EQNGTKDVLFYDRVLCDVPCSGDGTMRKNIDVWKKWTTSNSLHLHGLQLRIAVRGVEQLAVGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELVDASADLPGLKYMPGITSWKLMTKEGQWYSDWSEVPTNRHTQIRPTMFPPTDPEKLQSMKLERCMRILPHHQNTGGFFVAVLMKKGPMPWNR--------RQPKLRNKGATPSTAQ---PEEPPAEEGDGETPSEEPPCISDASENPP-------------EPEAK-KDGVCGPPPSKKMKLFGFKEDPFVFLTEDDPVFPPIQTFYNLSSDFPKLNVLTRTHEGKKRHLYMVSKELRNVLLNNSER-MKVINTGVKVWSRNNDGEQFGCAFRLAQEGIYTLNPYIRA--RVINISVEDVKVLLTEENPFLSRLGEDAHAQAKKLEMGSIVLRYQPDLKDPDA---PQCPIELCGWRGKTSIRAFVPRNERLHYLRMVGVE 690          

Query:  156 TMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD---VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARI--FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQY--DLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
             MR  LPAT R+TG++  ++E+   +K K+ +  I   +ID  +  +  P A   SWYPDE AW  N S+  +RK+P L+K H FL+SET+CG ISRQEAVSM+PPLLL IE HHK+LD+CAAPGSKTAQL+EMLH+  D   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  PR+ +   +    K  + +DR+L DVPCSGDGT+RKN D+W +W+    ++ H LQ++I  R +E L  GGRMVYSTCSLNPIEDEAV+A++L +++G + LVD S  L GL    G+T WK+M K+  W S   EVP       R ++FPP D   + S+ L+ C RILP +QNTGGFF+A+L K   +PW +         QP      A+  T++   P E     G+   PSEE      +                   P A   +     PP KK ++  FKEDPF ++  DD  +  ++ FY +S +FP   ++ R  +GK+R+ Y  ++ L+ ++  NS+R +  +N GVK++  + D    G  +R+ QEG+  +  +I +  R++  +  D+  LLT + P ++   +      + L +G ++ +Y  DL++ D+   P+ P+   GWRG++S+R +V  +ER H LR+ G+E
Sbjct:    3 AMREPLPATIRITGYKSHAKEILHTLKEKYFKD-IQDLEIDGQK--IEAPQA--LSWYPDEQAWHTNMSRKILRKSPLLEKFHQFLVSETECGNISRQEAVSMIPPLLLKIEPHHKILDMCAAPGSKTAQLIEMLHSDMDVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASCIPRLMV---EQNGTKDVLFYDRVLCDVPCSGDGTMRKNIDVWKKWTTSNSLHLHGLQLRIAVRGVEQLAVGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELVDASADLPGLKYMPGITSWKLMTKEGQWYSDWSEVPTNRHTQIRPTMFPPTDPEKLQSMKLERCMRILPHHQNTGGFFVAVLMKKGPMPWNR--------RQPKLRNKGATPSTAQ---PEEPPAEEGDGETPSEEPPCISDASENPP-------------EPEAK-KDGVCGPPPSKKMKLFGFKEDPFVFLTEDDPVFPPIQTFYNLSSDFPKLNVLTRTHEGKKRHLYMVSKELRNVLLNNSER-MKVINTGVKVWSRNNDGEQFGCAFRLAQEGIYTLNPYIRA--RVINISVEDVKVLLTEENPFLSRLGEDAHAQAKKLEMGSIVLRYQPDLKDPDA---PQCPIELCGWRGKTSIRAFVPRNERLHYLRMVGVE 629          

Query:  429 CGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKP 1373
             G    Q A S+LP + L  +    VLD+ +APG KT  + +++        TGV+IAND  + R   +V  + RL     ++   D   FP++         G     FDR+L D PCSG G + K+  +              LQ +++  +++ +      GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G TR                        F+   F P+      L+  RR  P + N  GFF+A L+K S      P+   E+E        VAS+E S+ S P++ KP
Sbjct:  333 AGHYMLQGASSLLPVMALSPQEGETVLDMSSAPGGKTTYMAQLMRN------TGVIIANDASADRLKSVVGNIHRLGVTNSIICNYDGRQFPKVM-------GG-----FDRVLLDAPCSGTGVISKDPAVKTSKDDSDIQRSAHLQKELILAAIDSVNAESQTGGYLVYCTCSIMVEENEWVVDYALKKR--NVKLVP-----TGLDFGKEGFTR------------------------FKEKRFHPS------LKLTRRFYPHSHNMDGFFVAKLKKFSNTIPTAPADQKEEEEPAEAETPVASEEPSKNSKPAKSKP 597          

Query:  429 CGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKP 1373
             G    Q A S+LP + L  +    VLD+ +APG KT  + +++        TGV+IAND  + R   +V  + RL     ++   D   FP++         G     FDR+L D PCSG G + K+  +              LQ +++  +++ +      GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G TR                        F+   F P+      L+  RR  P + N  GFF+A L+K S      P+   E+E        VAS+E S+ S P++ KP
Sbjct:  365 AGHYMLQGASSLLPVMALSPQEGETVLDMSSAPGGKTTYMAQLMRN------TGVIIANDASADRLKSVVGNIHRLGVTNSIICNYDGRQFPKVM-------GG-----FDRVLLDAPCSGTGVISKDPAVKTSKDDSDIQRSAHLQKELILAAIDSVNAESQTGGYLVYCTCSIMVEENEWVVDYALKKR--NVKLVP-----TGLDFGKEGFTR------------------------FKEKRFHPS------LKLTRRFYPHSHNMDGFFVAKLKKFSNTIPTAPADQKEEEEPAEAETPVASEEPSKNSKPAKSKP 629          

Query:  429 CGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKP 1373
             G    Q A S+LP + L  +    VLD+ +APG KT  + +++        TGV+IAND  + R   +V  + RL     ++   D   FP++         G     FDR+L D PCSG G + K+  +              LQ +++  +++ +      GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G TR                        F+   F P+      L+  RR  P + N  GFF+A L+K S      P+   ++E        VAS+E S+ S P++ KP
Sbjct:  365 AGHYMLQGASSLLPVMALSPQEGETVLDMSSAPGGKTTYMAQLMRN------TGVIIANDASADRLKSVVGNIHRLGVTNSIICNYDGRQFPKVM-------GG-----FDRVLLDAPCSGTGVISKDPAVKTSKDDSDIQRSAHLQKELILAAIDSVNAESQTGGYLVYCTCSIMVEENEWVVDYALKKR--NVKLVP-----TGLDFGKEGFTR------------------------FKEKRFHPS------LKLTRRFYPHSHNMDGFFVAKLKKFSNTIPTAPADQ-KEEEPAEAETPVASEEPSKNSKPAKSKP 628          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAG-TDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLP------------DSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEH 860
            ++N     YY+       ++W  F   +R  LPATFR+TG++  + E+   +K+KF  +L+    ++ +   V  P  +   WYP+E  WQ+N S+  IRK   L+  H FLI+ET+ G ISRQEAVSM+PPLLL +E HHKVLD+CAAPGSKTAQL+EMLH+  +  +P G +IAND ++KRCY++VHQ +RL SPC++V   DA   P + +              + + + +  + FDRILADVPCSGDGTLRKN D+W +W+P  G+N H
Sbjct:   13 KENKQFEAYYQEQAIVPKDEWGAFMEALREPLPATFRITGYKSHADELLRCLKSKFFSELV---GLEVDGQPVEAP--QQLEWYPNEFGWQVNLSRKSIRKCHLLEAFHQFLITETESGNISRQEAVSMIPPLLLKVEPHHKVLDMCAAPGSKTAQLIEMLHSDMSTPLPDGFIIANDSDNKRCYLLVHQSKRLHSPCVIVCNHDAGSLPLLQMTPATSAAAGEAAATATAATTRRFLRFDRILADVPCSGDGTLRKNIDVWKKWTPGNGLNMH 281          

Query:   84 NDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML----TEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
            ND +M    G+F  +  +  EF        P T R    + + RE         L Q ++      N  V   PL K   W   ++   +  S + +  TPE    H  L           Q A S+LP + L  + + K+LD+CAAPG KT+   +++        TG ++AND+ S+R   +V  L RL     +V   D     ++        SG     FDR+L D PCSG G + K+  +         +    LQ ++L  +++ L    T GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G TR+K                    R F  S           L+  RR  P   N  GFF++  +K+S
Sbjct:   82 NDFLMSLLSGLFPLS--ELIEFLEANEVHRPVTIRTNTLKTRRRE---------LAQALI------NRGVNLDPLGK---W--SKVGLVIFDSSVPVGATPEYLAGHYML-----------QGASSLLPVMALAPQENEKLLDMCAAPGGKTSYAAQLMRN------TGAIVANDVNSERLKSVVGNLHRLGVTNSIVCNYDGRALAKVM-------SG-----FDRVLLDAPCSGTGIISKDPSVKTSKDEKDILRCAHLQKQLLLTAIDCLDAASTTGGFLVYCTCSVTVEENEWVVDYALRKRN--VKLVP-----TGLDFGKEGFTRFK-------------------ERRFHPS-----------LKLTRRFYPHTHNMDGFFVSKFKKLS 389          

Query:   84 NDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML----TEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
            ND +M    G+F  +  +  EF        P T R    + + RE         L Q ++      N  V   PL K   W   ++   +  S + +  TPE    H  L           Q A S+LP + L  + + K+LD+CAAPG KT+   +++        TG ++AND+ S+R   +V  L RL     +V   D     ++        SG     FDR+L D PCSG G + K+  +         +    LQ ++L  +++ L    T GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G TR+K                    R F  S           L+  RR  P   N  GFF++  +K+S
Sbjct:   91 NDFLMSLLSGLFPLS--ELIEFLEANEVHRPVTIRTNTLKTRRRE---------LAQALI------NRGVNLDPLGK---W--SKVGLVIFDSSVPVGATPEYLAGHYML-----------QGASSLLPVMALAPQENEKLLDMCAAPGGKTSYAAQLMRN------TGAIVANDVNSERLKSVVGNLHRLGVTNSIVCNYDGRALAKVM-------SG-----FDRVLLDAPCSGTGIISKDPSVKTSKDEKDILRCAHLQKQLLLTAIDCLDAASTTGGFLVYCTCSVTVEENEWVVDYALRKRN--VKLVP-----TGLDFGKEGFTRFK-------------------ERRFHPS-----------LKLTRRFYPHTHNMDGFFVSKFKKLS 398          

Query:  450 EAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCI-------------VVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----------GGRMVYSTCSLNPIEDEAVLAAILSQA 989
            +A S+LP L LD++  H+VLDLCAAPG KT  L++   A  D++ +     ND+ + R      +LQR+    +             V VR    IF          KS +   ++DR+L D PC+ D           R S     N  F + ++  R      +          GG +VYSTCSL+ +++  V+ A LS A
Sbjct:  159 DAASLLPVLALDVQLGHRVLDLCAAPGGKTLALLQT--ACCDQLTS-----NDVSASR----TGRLQRVLRTYVPRDAEEAGVPAGGVSVRTRDGIF--------WLKSAEERGVYDRVLVDAPCTND-----------RHSLHEEENNIFSRSRMKERQQLPALQTQLLLLACRPGGVVVYSTCSLSQLQNSCVVEAALSLA 331          

Query:  477 LLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPM-----------------LFDRILADVPCSGDG---------TLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLA 971
            +LD+    +VLD+CAAPG KT  +  ++        TG +IA D  + +   + +   RL    I           + F  DS       P                   FDR+L D PCS  G         +LR+ Q   P            LQ K+L  ++ +L  GG ++Y+TCS+   E+E  +A
Sbjct:  234 VLDVRPGLRVLDMCAAPGGKTTHIATLMGD------TGEIIALDKTAAKVQKIQNNASRLNLKSI-----------QTFCCDSTQAIASGPHTGKGLLWWVGHPPFPEEYFDRVLLDAPCSALGKRPCLGFPASLRQLQSYAP------------LQRKLLAAAVALLRPGGVLLYTTCSVASAENERQVA 395          

Query:   48 RANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDS--LNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARI---FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGK-RRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEF-SQSMQQAF----QILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLL-RLCGME 2123
            RA K  +E  ++N+   +YYK +  +  ++W EF  T +  LP TFR+TG R+ + EV  L K + L  L     ++     +  P+  P  WYPD +AWQL+  K  IRK  +  K   FL+ E   G ISRQEAVSM+PP++L+++ HH VLD+CAAPGSKTAQL+E LH  TD+ P+G V+AND +++R +M+VHQL+RL S  ++VV  DA  FPRI L    S +    + FDRIL DVPCSGDGT+RKN ++W  W+   G+  H +Q+ IL R L +L   GR+VYSTCSLNPIE+EAV+A  L +    +RLV+  ++L GLI   G+++W V  ++ +  +  DE  +        S F P++ ++   NLQ C R+ P  QNTGGFFI + EKV             ++S  +  E ++S+  +  S+  + K +                                             K E  +KK R+     E+PF ++ P  +A      FY I   F     + RNA G+  R  Y     LK +++AN DR +  +  GVKLF          +RI  E + I++  + S  R+V +    L  LL    P   +  S+++   F      LS G        +ND ++E   +P+    W+G   +   V   +   LL R+ G++
Sbjct:   22 RAQKNWSELVKENEKWEKYYKTLALFPEDQWEEFKKTCQAPLPLTFRITGSRKHAGEVLNLFKERHLPNLT---NVEFEGEKIKAPVELP--WYPDHLAWQLDVPKTVIRKNEQFAKTQRFLVVENAVGNISRQEAVSMIPPIVLEVKPHHTVLDMCAAPGSKTAQLIEALHKDTDE-PSGFVVANDADARRSHMLVHQLKRLNSANLMVVNHDAQFFPRIRL-HGNSNNKNDVLKFDRILCDVPCSGDGTMRKNVNVWKDWNTQAGLGLHAVQLNILNRGLHLLKNNGRLVYSTCSLNPIENEAVVAEALRKWGDKIRLVNCDDKLPGLIRSKGVSKWPVYDRNLTEKTKGDEGTL-------DSFFSPSEEEASKFNLQNCMRVYPHQQNTGGFFITVFEKV-------------EDSTEAATEKLSSETPALESEGPQTKKI---------------------------------------------KVEEVQKKERLPRDANEEPFVFVDPQHEALKVCWDFYGIDNIFDRNTCLVRNATGEPTRVVYTVCPALKDVIQANDDR-LKIIYSGVKLFVSQRSDIECSWRIQSESLPIMKHHMKS-NRIVEANLEMLKHLLIESFPNFDDIRSKNIDNDFVEKMTKLSSGCAFIDVS-RNDPAKENLFLPV----WKGNKCINLMVCKEDTHELLYRIFGID 646          

Query:  144 EFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEML----TEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSE 1346
            EF+       P T R    + + R+         L Q +V      N  V   P+    SW   ++  Q+  S++ I  TPE    H  L           Q A S LP + LD   + ++LD+ AAPG KT  +  M+        TG V AND    R   ++  + RL     +V   DA  FP++         G     FDRIL D PCSG G + K+Q +    +    +    LQ ++L  +++ +      GG +VYSTCS+   EDEAV+   L + +  V+LVD     TGL I +   T                        S+R   F P+      ++  RR  P   N  GFF+A  +K+       PS   + ++     ET A +E  E
Sbjct:  260 EFFEANEIARPITIRTNTLKTRRRD---------LAQTLV------NRGVNLQPIG---SWT--KVGLQIFDSQVPIGATPEYLAGHYIL-----------QAASSFLPVIALDPHENERILDMAAAPGGKTTYISAMMKN------TGCVFANDANKSRTKSLIANIHRLGCTNTIVCNYDAREFPKVI-------GG-----FDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPHLQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRK-RPNVKLVD-----TGLAIGKEAFT------------------------SYRGKKFHPS------VKLARRYYPHTYNVDGFFVAKFQKIG------PSSFDDNQASAKEKETAARKEALE 574          

Query:   78 RKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDK-IPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPAD--VDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPW-MKPSKSGEK--ESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARI---FKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVE--ANSDRDINFVNLGVKLFGISEDRSFNG-YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQ-QAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRL 2111
            ++N +  +YYK +      +W +F T +R ELP+TFR+TG R  +  +  ++K+ +L+QL  K    + +  V  P + P  WYPDE+AW++N S+  IRK+P +KK H FL+ ET+CG ISRQEAVSM+PPLL+DI+   K+LD CAAPGSKT+Q++EMLH   +  I  G+VIAN++++KRCYM++HQ +RL+SP  V+   DAS +P + +   +    ++P+LFDRIL DVPCSGDGT+RKN  +W +W+P LGV+ H  Q++IL R++EML  GGR+VYSTC+++PIE+E+V+A +L  + G + LVD+SN L  L    GL  WK+MMKD S  +  D    A    FR S+ PP D    +++L+ C R+ P  Q+TGGFFIA L K    PW ++   S  K    QP P E     +TS+  D +       +SG+                  +   +   +    + T + +  SEPP KK R    FKEDPF  +  DD  W  ++ ++     FP+ QL+ R+  GK+RN Y  +  ++ L+E     + D+  ++ GVK     +       +R++QEG+E +  ++   +R V  T+ D+ TL+ +D P   +FSQS + Q  ++  +G V+F YD ++    +  +  L F GW+ R+S+R  +   ++ H   L
Sbjct:    3 KENPMFEKYYKALGIVPESEWEQFITALRQELPSTFRITGSRSHANMLLQVLKHNYLDQL--KEATAHLDEQVDPPTSLP--WYPDELAWKVNLSRKFIRKSPSIKKFHQFLVQETECGNISRQEAVSMIPPLLMDIKPGQKILDTCAAPGSKTSQIIEMLHGDKETGIAEGLVIANELQNKRCYMLIHQSKRLRSPSCVITNHDASTYPTLHV--KKENGDRTPLLFDRILCDVPCSGDGTMRKNPLIWNKWTPQLGVSLHRTQLRILARAMEMLEVGGRIVYSTCTMSPIENESVVAEMLRNSDGALELVDLSNELPNLKRSPGLHSWKLMMKDGSEVTGCDPGSPAFLGGFRPSMLPPPDNEAKAMHLECCIRVYPHQQDTGGFFIAALVKTKQAPWEIRRCNSIAKWLPWQPPP-ENKVDADTSDMQDDTMTN--EDDSGV-----------------DDFNKETYDVNDVFAKTESENTSSEPPCKKPRTNLGFKEDPFILLPDDDPHWPIIRDYFGFVPSFPSAQLLIRSIGGKKRNVYLVSRNVQALLECAGGDNDDVKLISAGVKTLTRCDGEELGCEFRLMQEGIENVVPYV--TKRKVFITQEDVFTLVRHDKPFSNKFSQSTRDQLSKVSGLGCVIFLYDPESHSPSDTIKCNLCFCGWKARTSIRALMSRSDKMHYATL 665          

Query:   84 NDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTE----GGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
             + +ME +  +F  N  +  EF        P T R    + + R+         L Q ++      N  V   P+ K   W   ++   +  S + I  TPE    H  +           Q + SMLP + L  +   +VLD+CAAPG KT  L  ++        TG+V+AND + +R   +V  + RL     VV   D   FP++         G     FDR L D PCSG G + K+  +    +    +    +Q +++  +++ +      GG +VYSTCS+   EDE V+   LS+    V+LV      TGL     G ++                        FR   F P+      L+  RR      N  GFF+A L+K S
Sbjct:   99 GEFLMEKFLEMFQLN--ELIEFLEANEVHRPVTIRTNSLKTRRRD---------LAQALI------NRGVNLDPVGK---W--SKVGLVVYDSSVPIGATPEYLAGHYMI-----------QGSSSMLPVMALAPQEKERVLDMCAAPGGKTTYLAALMKN------TGIVVANDAKKERTKALVANIHRLGVTNTVVCNYDGRAFPKVM-------GG-----FDRTLLDAPCSGTGVISKDPSVKTNKTEKDILRCSHVQKELILAAIDSVDAKSPTGGYIVYSTCSIMVEEDEWVVDYALSKRH--VKLVP-----TGLDFGREGFSK------------------------FRGRHFHPS------LKLTRRFYAHAHNMDGFFVAKLKKFS 406          

Query:  450 EAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVM 1073
            +A S+LP + LD+     VLD+CA+PG KT  ++++L         G ++AN+    R   +   +Q        + +   +I  R    D     G  P  +DRIL D PCS D    ++      WS         LQ K++  +L  LT  GR+VYSTC+++P E++ V+  +L   +   + + I       ISE  +  W  M
Sbjct:   12 DAASLLPVICLDVGPDSTVLDMCASPGGKTVAMMQLLSE------RGGLVANEPTQSRRRKLRKVIQEY------IPKGQTNITIRGM--DGTKFGGLEPCSYDRILVDAPCSTDRHCLRSGFQTDSWSEKKSQKFSQLQNKLVMSALGSLTSDGRVVYSTCTMSPYENDGVIQGVLENFRHGGKNISIER-----ISEEQIAAWGEM 200          

Query:  477 LLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDAS-IFPRIFLPDSQSKSGKSP----MLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIA 1238
            +L  +S   VLD+CAAPG KT  +  ++         G+++A D    +   ++   +  +   +     DAS        P S+  S  SP      FDRIL D PCS  G  R    +  +        +  LQ KI   ++ +L  GG +VYSTC++ P E+E  +A  L    G +RLV     L G               DC   S  D   +      RSS+ P  DVD++                GFFIA
Sbjct:  266 ILGPQSGESVLDMCAAPGGKTCHIAALMKN------KGLIVAFDKSQPKIQKIIANCEMQKVSIVKTHVIDASKALDTKAAPSSRDVSTTSPPYPPEAFDRILLDAPCSALGQ-RPQSVVHMKLKELQSFPK--LQRKIFSSAVGLLRPGGTLVYSTCTITPEENEKQVAWALRSFPG-LRLVPQVPHLGG-----------PGFPDCGL-SDHDRGLVQRFDPTRSSVEPCCDVDTI----------------GFFIA 486          

Query:  432 GFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQD-ASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRK---------NQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEK 1250
            G I  Q+  S LP  ++ +     V+D CAAPG+K++ L   L+        G V + DI + R  +M  Q+++  + C+V   +    + PR     SQ ++       + I+ D  CSG G + +           DL  R            Q+ +L  +        ++ YSTCS++  E+E V+   L  +QG   L               L  W                P      F+ +            + C R  P++ +T GFF+AL ++
Sbjct:  202 GHILLQDKASCLPAHVISLPPGAHVIDACAAPGNKSSHLAAKLN------NNGRVFSFDISASRLAVMQKQMKKAGATCVVTEHKSFLDVDPR----SSQYRN------VEYIVVDPSCSGSGIISRLDGLVSDEQEDDLQQRLESLAD-----FQLSVLTHAFS-FPAVKKVAYSTCSIHSQENEDVVHKALKVSQGQFELAH------------ALESW----------------PSRGLPVFQGA------------EKCLRASPESDHTNGFFVALFQR 422          

Query:   33 RHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTD-KIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPA---DVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKE-SQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIF--KEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNG--YRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGME 2123
            R N G    Y +   ++N L  +YYK        ++ +F   MR  LPAT R+TG++  ++E+   +K+K+ + L    ++D +   +  P  +P SWYPDE+AW  N S+  IRK+P L+K H FL+SET+ G ISRQEAVSM+PPLLL I+ HHK+LD+CAAPGSKTAQL+EMLHA  D   P G VIAND+++KRCY++VHQ +RL SPCI+VV  DAS  P + + DS SK  K  +L+DR+L DVPCSGDGT+RKN D+W +W+    ++ H LQ++I  R +E L  GGRMVYSTCSLNPIEDEAV+AA+L +++G + L D S  L GL    G+  WK+M K+  W S   EVP +     R S+FPP     V S++L+ C RILP +QNTGGFF+A+L K + +PW K      K+ S  S   T  S  T    D  ++     + G+P E                 + +      + +    +     PP KK ++F  KEDPF ++  DD  +  ++ FY++S +FP   ++ R  +GK+R+ Y  ++ L+ ++  NS+R I  +N GVK++  + D    G  +R+ QEG+  ++ ++ S  R++    +D+  LLT + P +++  +      + + +G V+ ++ + N D+   P+ P++  GWRG++S+R +V  +ER H LR+ G+E
Sbjct:   18 RENAGWGAGYADIV-KENKLFEQYYKEQGLVPEGEFEQFMEAMREPLPATIRITGYKSHAKEILHCLKDKYFKDL---QELDIDGQKIEAP--RPLSWYPDELAWHTNMSRKIIRKSPLLEKFHQFLVSETESGNISRQEAVSMIPPLLLKIQPHHKILDMCAAPGSKTAQLIEMLHADMDVPFPEGFVIANDVDNKRCYLLVHQAKRLNSPCIMVVNHDASCIPALQV-DSDSK--KDVLLYDRVLCDVPCSGDGTMRKNIDVWKKWTTSNSLHLHGLQLRIAVRGVEQLAVGGRMVYSTCSLNPIEDEAVIAALLEKSEGALELDDASADLPGLKYMPGVASWKLMTKEGQWYSDWSEVPKSRHTQIRPSMFPPKGPEKVASMHLERCMRILPHHQNTGGFFVAVLVKKAPMPWNKRHPKLRKDFSSSSAAMTGGSPVTPSPEDTPQLLSEEADGGVPVE-----------TVDGAAQQEALHGAPKEAGAGGDGACGPPPSKKLKLFGYKEDPFVFLTEDDPVFSAIQSFYDLSPDFPKLNVLTRTHEGKKRHLYMVSKELRNVLLNNSER-IKVINTGVKVWSRNSDGEEFGCAFRLAQEGIYTLQPYVCS--RIIRVVMNDIKVLLTQENPFLSKLEEDAHAQAKQMGMGSVVLKF-IPNSDNPTEPQCPIQLCGWRGKTSIRAFVPRNERLHYLRMLGVE 699          

Query:  429 CGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLT----EGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEM 1367
             G    Q A S LP + L  +    VLD+ +APG KT  + +++        TGV++AND  S+R   +V  + RL     VV   D   FP++         G     FDR+L D PCSG G + K+  +         +    LQ +++  +++ +      GG +VY TCS+   E+E V+   L +    V+LV      TGL   + G T +K                      FR   F P+      L+  RR  P + N  GFF+A L+K S +    P+   EKE +    +T  ++ T+  S P ++
Sbjct:  385 AGHYMLQGASSFLPVMALSPQEGEMVLDMSSAPGGKTTYIAQLMRN------TGVIVANDANSERLKSVVGNIHRLGVTNTVVCNYDGRQFPKVM-------GG-----FDRVLLDAPCSGTGVIAKDPAVKTSKDEADILRSAHLQKELILSAIDSVNAESPSGGYVVYCTCSITVEENEWVVDYALKKR--NVKLVP-----TGLDFGKEGFTNFK---------------------QFR---FHPS------LKLTRRFYPHSHNMDGFFVAKLKKFSNVV---PTVPAEKEEE----KTDTTEATASPSAPKDL 640          

Query:  450 EAVSMLPPLLLDIESHHKVLDLCAAPGSKT-----AQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQ----SKSGKS-----PMLFDRILADVPCSGD--GTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVL--AAILSQAQGTVRLVDISNR-LTGLISES 1049
            +A S+LP L LD++  H VLDLCAAPG KT      QLV  L              ND  + R   +   L               S  P+ FL D +    S  G +        FDR+L DVPC+ D    +  + +++ +           LQ ++L   ++    GG +VYSTCSL+  ++ +V+  A  L+Q    ++L  ++ R LT + S++
Sbjct:  168 DAASVLPCLALDVQEGHTVLDLCAAPGGKTLALLQTQLVRFL------------CVNDASTSRTSRLRKVLH--------------SYVPKQFLTDERVRISSFDGTTWGEIEKNTFDRVLVDVPCTTDRHSLMEDDNNIFSKSRTGERRRLPQLQAELLLAGIQAACPGGEIVYSTCSLSLNQNLSVVEQAVYLAQENFGIQLQVVNLRALTKMFSDT 360          

Query:  453 AVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPC----IVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGD-----------GTLR-KNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAIL 980
            A S+LP L L +    +VLDLC+APG K    + ++ + T       +  N+ +  R   +   L+    P     + V  +D  +        +Q+++G     +D++L D PCS D           G  R KN++  P            LQ ++LR +L  +  GG +VYSTC+L+  E+ AV+  IL
Sbjct:  190 AASLLPVLALQVRDEDRVLDLCSAPGGKA---IAIMQSAT----PAFLCCNEPDPHRRDWLTKTLESFLPPSLNSRVTVTGRDGRLI-------AQTEAG----FYDKVLVDAPCSNDRSWLYSSSNQQGAQRLKNREKLPS-----------LQAQLLRSALSAVRPGGVVVYSTCTLSSYENWAVVEKIL 352          

Query:  432 GFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDS-QSKSGKSPMLFDRILADVPCSGDGTL----RKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVS 1256
            G I  Q+  S LP  LL   S   V+D CAAPG+KT+ L  ++         G + A D+++KR   M   L R    C  +  QD   F ++  PDS Q K        + +L D  CSG G +    R + D   R +          Q++ L  ++       R+VYSTCS++  E+E V+ A L Q   + RLV +            L +W                           L P        L  C R       T GFF+ALLEK S
Sbjct:  203 GHIILQDKASCLPAYLLKPPSGSHVIDACAAPGNKTSHLAAIMKN------KGKLFAFDLDAKRLATMSTLLLRAGVTCQQLAHQD---FLKVN-PDSPQYKD------VEYVLLDPSCSGSGMVCLQDRSSAD-QTRLASLAA-----FQLRCLNHAVR-FPRLKRLVYSTCSIHSQENEEVITAFLQQ-NSSFRLVPL------------LPQWP-----------------------ERGLAP--------LSQCLRASTSKTRTHGFFVALLEKHS 415          

Query:   21 MVKKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMXXXXXXXXXXXXXXXXXXQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKPDDKAWDGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFIGSVRRLVLSTRSDLMTLLTYDMPLITEFSQSMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDVVAAARKDNGDRNYCFG 2183
            MVKKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSK GKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMEIKSE KEDSVEKETDESQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKPDDKAW GLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFIG VRRLVLSTRSDLMTLLTYDMPLITEFSQ MQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDVVAAARKDNGDRNYCFG
Sbjct:    1 MVKKRHNRGRANKYLNEEDRKNDLMMEYYKGIFNWNTEKWNEFYTTMRTELPATFRVTGFRQQSREVQWLIKNKFLEQLIVKNKIDNNESVVSGPLAKPFSWYPDEMAWQLNASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDASIFPRIFLPDSQSKFGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGLISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKVSGLPWMKPSKSGEKESQPSPMETVASQETSEFSDPSEMKPVPGESGLPSEEELMEIKSEAKEDSVEKETDESQIRIRPSATVTNSEKSEPPKKKARIFKEDPFYYIKPDDKAWYGLKQFYEISEEFPNQQLMYRNADGKRRNYYFTNELLKQLVEANSDRDINFVNLGVKLFGISEDRSFNGYRILQEGVEIIERFIGPVRRLVLSTRSDLMTLLTYDMPLITEFSQPMQQAFQILSIGPVMFQYDLQNDDSEEMPRIPLRFAGWRGRSSLRHYVGVHERSHLLRLCGMEPVDVVAAARKDNGDRNYCFG 721          

Query:  357 ASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDA-SIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKV 1253
            ++K  I  TPE    H  L           Q + SMLP + L  +   ++LDLCAAPG KT+ + +++        TG++ ANDI   R   +   L R+     VV+  D  SI  ++               F+R+L D PC+G G + K++ +              +Q ++L  +++    GG +VYSTCS+   E+E V              +D + R   + ISE+GL   K  M                  +FR+  F      + N+   RR  P   N  GFF+A L+K+
Sbjct:  293 SAKCAIGATPEYLAGHYIL-----------QGSSSMLPVMALAPKKGERILDLCAAPGGKTSHIAQIM------ANTGIIFANDINKDRLKAVTSNLSRMGVMNTVVICNDGRSIHKKV-------------KNFNRVLCDAPCTGTGVISKDKSIKASKDEEDLKILTCIQKQLLCSAIDACKVGGYVVYSTCSILVEENEQV--------------IDYACRKRNVKISETGLFGIKGFM------------------NFRAKHF------NQNMDRTRRYYPHENNMDGFFLAKLQKI 525          

Query:  357 ASKMEIRKTPELKKLHNFLISETDCGFISRQEAVSMLPPLLLDIESHHKVLDLCAAPGSKTAQLVEMLHAGTDKIPTGVVIANDIESKRCYMMVHQLQRLQSPCIVVVRQDA-SIFPRIFLPDSQSKSGKSPMLFDRILADVPCSGDGTLRKNQDLWPRWSPFLGVNEHFLQMKILRRSLEMLTEGGRMVYSTCSLNPIEDEAVLAAILSQAQGTVRLVDISNRLTGL-ISESGLTRWKVMMKDCSWCSSIDEVPIAMRRSFRSSLFPPADVDSLNLQYCRRILPQNQNTGGFFIALLEKV 1253
            ++K  I  TPE    H  L           Q + SMLP + L  +   ++LDLCAAPG KT+ + +++        TG++ ANDI   R   +   L R+     VV+  D  SI  ++               F+R+L D PC+G G + K++ +              +Q ++L  +++    GG +VYSTCS+   E+E V              +D + R   + ISE+GL   K  M                  +FR+  F      + N+   RR  P   N  GFF+A L+K+
Sbjct:  293 SAKCAIGATPEYLAGHYIL-----------QGSSSMLPVMALAPKKGERILDLCAAPGGKTSHIAQIM------ANTGIIFANDINKDRLKAVTSNLSRMGVMNTVVICNDGRSIHKKV-------------KNFNRVLCDAPCTGTGVISKDKSIKASKDEEDLKILTCIQKQLLCSAIDACKVGGYVVYSTCSILVEENEQV--------------IDYACRKRNVKISETGLFGIKGFM------------------NFRAKHF------NQNMDRTRRYYPHENNMDGFFLAKLQKI 525