Aspartate--tRNA ligase, cytoplasmic

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDA---SRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+V+VEG V  V + + SCTQ  VEL ++ + V+S ++ RLPLQ++DA        +   A VN DTRLD R  +LRT T+QA+  L   I   F   L ++GF +I  P IISAASEGGANVF V YF + AYLAQSPQLYKQM I    +KV++I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DTMV IFK L++    EI  V KQF  EPF+FLEPTL L + E +AML EAG+EMG+ +DL+T NEK+LG L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQR+HDP +L E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:   56 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501          

Query:  919 TGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
             GLD+EM F+ HYHEV+  I DTMV IFK L++    EI  V KQF  EPF+FLEPTL L + E +AML EAG+EMG+ +DL+T NEK+LG L+K+K                             SNSYD FMRGEEI+SGAQR+HDP +L E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:    1 VGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKKQ---------------------------SNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 188          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI--EMGEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E    + V + G++H++R+ GK   F+V+RD    +QC+      ++  +      +   +   V    +L   P         EL  +  ++           I  A     DN +  + ++D +L+ R+  +R      I+     +   F  +   +G+ ++  P+++    EGGA +F++ YF ++A+L QS QLY +  +      V+ I++ +RAE S T RHL E+T ++ E  F   + ++L+ + D +  +   + K+ A  I   +   N +P +   P   +N+S+ +  L E  +  E G F    ED+    E      +      +  +L +FP+ ++ FY     +    + S D  M    EI+ G+ R+ D   +     + GI       Y +  +YG  PH G G+GLER +   L   +IR V ++PR   R TP
Sbjct:  121 EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCV------LADELCQCYNGVLLSTESSVAVYGMLNLTPKGKQAPGGHELSCDFWEL-----------IGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLP-ALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFL-TFDDLLNRLEDLVCDVVDRILKSPAGSIVH-ELNPNFQPPK--RPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPE-----RLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPRFVQRCTP 548          

Query:  604 YRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVK-----------YFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTI-----CDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAG------IEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFS-NSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDP 1548
            Y +F  RT    +I+ +  +      S+ +  GF  I+ P I S  SEG   +F+++           +FN  A+L  S QL+ ++ + G   +V+T    FRAENS + RHL EF  ++ E+ F     +++  I       TM+ + K  E            Q +          LI++++E V +L +A        E G   DL T +EK L K          +V++ +PL ++PFY   + D P  +  + D  + G  E+  G  R      L E   + G+  +  + YL+   +G  PH G G+G ER +   LG+DNI+ V  FPR P
Sbjct:  142 YPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEV-MSGAFTQVFTFGPTFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGA--DLRTEHEKYLVKHCGN---IPVFVIN-YPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLT-EVYQWYLDLRRFGSVPHGGFGMGFERYLQCILGVDNIKDVIPFPRFP 472          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDA---SRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGF 705
            A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+V+VEG V  V + + SCTQ  VEL ++ + V+S ++ RLPLQ++DA        +   A VN DTRLD R  +LRT T+QA+  L   I   F   L ++GF
Sbjct:   23 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGF 182          

Query:  196 ISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASR---------PDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            ++F+++  +N S A+K V ++G +H  R  GK  F+V+R  +Y+VQ   ++ EKISK M+ F+ +I KES+V+V  T+  V+ P+ESCTQ  VEL  + V VVS S  +LPLQIEDASR          + +N LA VNLDTRLD R  +LRT T+ AI  +   I   F + L  +GF +I  P IISA SEGGANVFEV YF   AYLAQSPQLYKQMAI G  +KVYTI  VFRAE+SNTHRH+TEF GLDLEM F+ HYHEV+ TI + +  +FK L++N   EIAAV  Q+  EPF+F EP LIL + + + +L E GIE+G+ +DL+T  EK LGKL+K+K+ TDFYVLDKFPL+VRPFYTMPDA    +SNSYD FMRGEEI+SGAQR+HD  ML E A  H + L  I+ Y++SF+YGC PHAGGGIGLERV ML+LGL NIR  S+FPRDP RLTP
Sbjct:   67 LNFLKVKEINVSNATKDVWVRGRIHTTRSKGKNCFLVLRQGVYTVQVAMFMNEKISKQMLKFVSSISKESIVDVYATINKVDNPIESCTQKDVELLAQQVFVVSTSAPKLPLQIEDASRRAPTDEEKASEQENQLAVVNLDTRLDNRVIDLRTPTSHAIFRIQAGICNQFRNILDVRGFVEIMAPKIISAPSEGGANVFEVSYFKGSAYLAQSPQLYKQMAIAGDFEKVYTIGPVFRAEDSNTHRHMTEFVGLDLEMAFNFHYHEVMETIAEVLTQMFKGLQQNYQDEIAAVGNQYPAEPFQFCEPPLILKYPDAITLLRENGIEIGDEDDLSTPVEKFLGKLVKEKYSTDFYVLDKFPLSVRPFYTMPDAHDERYSNSYDMFMRGEEILSGAQRIHDADMLVERAKHHQVDLAKIQSYIDSFKYGCPPHAGGGIGLERVTMLFLGLHNIRLASLFPRDPKRLTP 531          

Query:  196 ISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASR---------PDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            ++F+++  +N S A+K V ++G +H  R  GK  F+V+R  +Y+VQ   ++ EKISK M+ F+ +I KES+V+V  T+  V+ P+ESCTQ  VEL  + V VVS S  +LPLQIEDASR          + +N LA VNLDTRLD R  +LRT T+ AI  +   I   F + L  +GF +I  P IISA SEGGANVFEV YF   AYLAQSPQLYKQMAI G  +KVYTI  VFRAE+SNTHRH+TEF GLDLEM F+ HYHEV+ TI + +  +FK L++N   EIAAV  Q+  EPF+F EP LIL + + + +L E GIE+G+ +DL+T  EK LGKL+K+K+ TDFYVLDKFPL+VRPFYTMPDA    +SNSYD FMRGEEI+SGAQR+HD  ML E A  H + L  I+ Y++SF+YGC PHAGGGIGLERV ML+LGL NIR  S+FPRDP RLTP
Sbjct:   67 LNFLKVKEINVSNATKDVWVRGRIHTTRSKGKNCFLVLRQGVYTVQVAMFMNEKISKQMLKFVSSISKESIVDVYATINKVDNPIESCTQKDVELLAQQVFVVSTSAPKLPLQIEDASRRAPTDEEKASEQENQLAVVNLDTRLDNRVIDLRTPTSHAIFRIQAGICNQFRNILDVRGFVEIMAPKIISAPSEGGANVFEVSYFKGSAYLAQSPQLYKQMAIAGDFEKVYTIGPVFRAEDSNTHRHMTEFVGLDLEMAFNFHYHEVMETIAEVLTQMFKGLQQNYQDEIAAVGNQYPAEPFQFCEPPLILKYPDAITLLRENGIEIGDEDDLSTPVEKFLGKLVKEKYSTDFYVLDKFPLSVRPFYTMPDAHDERYSNSYDMFMRGEEILSGAQRIHDADMLVERAKHHQVDLAKIQSYIDSFKYGCPPHAGGGIGLERVTMLFLGLHNIRLASLFPRDPKRLTP 531          

Query:  247 VTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAK-VNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQM--AIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLE---MQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            V+IK ++H++R+ GK   F+V+RD    +QC+      ++  +      +   +   V+   ++   P         EL ++  +V           I  A     DN L +   +D  LD R+  +R      I+ +          +  + G+ ++  P+++    EGG+ +F + Y+ + AYL QS QLY +   A +G    VY IS+ +RAE S T RHL+E+  ++ E   + F +    +   +CDT+  +  +    +  E      +    PF+ +     + + +   + NE G +    ED+    E+ +   I         +L++FP  ++ FY    AD    + S D  M G  EI+ G+ R+     L  +  K G+       Y++  +YG  PH G G+GLER +      ++IR V ++PR   R  P
Sbjct:  124 VSIKAWVHRLRRQGKSLMFLVLRDGYGFLQCV------LNDKLCQSYDAVTLSTETSVQVYGIIKALPDGKSAPDGHELTVDYWEV-----------IGKAPAGGIDNVLNESAGVDVMLDNRHLVIRGENASRILRIRAAATRAMRDHFFAAGYTEVAPPTLVQTQVEGGSTLFGLDYYGEPAYLTQSSQLYLETCNAALG---DVYCISQSYRAEKSRTRRHLSEYQHVEAECAFITFDQLMDRIEALVCDTVDRLLADPVTKSLIEFVNPGYKAPARPFKRMPYKEAIEWLQKNDVRNEMGEKFVYGEDIAEAAERRMTDTIGVPI-----LLNRFPHGIKAFYMPRCADDNELTESVDLLMPGVGEIVGGSMRIWKEDQLLAAFEKGGLDSKNYYWYMDQRKYGSVPHGGYGLGLERFICWLTDTNHIRDVCLYPRFVGRCAP 545          

Query:  685 YLRSQGFRDINCPSIISAASEGGANVFEV-----------KYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNN-AAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            +  S+ F  I+ P +     EGG  VF+V               +  +L+ S QL+ + A+V   ++VY +   FRAE   +H HL+EF  L+ E+ F     E+   +   + H+   L  +    E A +  +  I   +F      + + E V +L   G ++      +  NE  L KL           +  +P+  +PFY   D      + S+D  + G  E+  G+ R        E   + G  +D    YLE    G  P  G GIG ER++   LG+ NI+    FPR
Sbjct:  132 FFMSRDFIHIDTPKLTRNDCEGGGEVFDVVTTTSTEAGDGGLKEEPMFLSVSSQLHLE-AMVSRLQRVYILGPSFRAERQQSHAHLSEFHMLEAEVAFVETIDEMCTLVESYIQHMISYLNSSKLEPETAIIGSKIPISNIKFPR----IRYDEAVHLLALKGSKVTAKSGFSKKNELDLVKLHDDHP----IFVTHYPVGQKPFYMARDGQ---LTLSFDLLVPGIGELAGGSLREQSA----EELQRRGCGIDW---YLEMRRRGQPPTGGFGIGFERMLQYLLGVQNIKDTVAFPR 411          

Query:  685 YLRSQGFRDINCPSIISAASEGGANVFEV-----------KYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNN-AAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            +  S+ F  I+ P +     EGG  VF+V               +  +L+ S QL+ + A+V   ++VY +   FRAE   +H HL+EF  L+ E+ F     E+   +   + H+   L  +    E A +  +  I   +F      + + E V +L   G ++      +  NE  L KL           +  +P+  +PFY   D      + S+D  + G  E+  G+ R        E   + G  +D    YLE    G  P  G GIG ER++   LG+ NI+    FPR
Sbjct:  132 FFMSRDFIHIDTPKLTRNDCEGGGEVFDVVTTTSTEAGDGGLKEEPMFLSVSSQLHLE-AMVSRLQRVYILGPSFRAERQQSHAHLSEFHMLEAEVAFVETIDEMCTLVESYIQHMISYLNSSKLEPETAIIGSKIPISNIKFPR----IRYDEAVHLLALKGSKVTAKSGFSKKNELDLVKLHDDHP----IFVTHYPVGQKPFYMARDGQ---LTLSFDLLVPGIGELAGGSLREQSA----EELQRRGCGIDW---YLEMRRRGQPPTGGFGIGFERMLQYLLGVQNIKDTVAFPR 411          

Query:  139 DQSVGKYGDAKL--EPFNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLA----KVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D + G+YG +++       +  +FV ++ ++  +   +V ++G +H  R  GKQ F+++R    +VQCI  VG+ ISK MV F GNIPKES+++++   V V   +ESCT+ ++EL +E + V+S++K++LPLQIEDASRP+  ++      +VN DTRLD R  +LRT  NQAI  L   +   F   L  QGF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI +T   IFK L    A EI +V +Q+ ++ F+FLEP LIL F++GVAML EAG+E G+ EDL+T NEK+LG+L+K K+ TDFY+LDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  HGI    I  Y+ESF YGC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   51 DHAAGRYGLSEMIQSKDKRSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKFAGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531          

Query:  139 DQSVGKYGDAKL--EPFNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLA----KVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D + G+YG +++       +  +FV ++ ++  +   +V ++G +H  R  GKQ F+++R    +VQCI  VG+ ISK MV F GNIPKES+++++   V V   +ESCT+ ++EL +E + V+S++K++LPLQIEDASRP+  ++      +VN DTRLD R  +LRT  NQAI  L   +   F   L  QGF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI +T   IFK L    A EI +V +Q+ ++ F+FLEP LIL F++GVAML EAG+E G+ EDL+T NEK+LG+L+K K+ TDFY+LDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  HGI    I  Y+ESF YGC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   51 DHAAGRYGLSEMIQSKDKRSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKFAGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531          

Query:  139 DQSVGKYGDAKL--EPFNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLA----KVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D + G+YG +++       +  +FV ++ ++  +   +V ++G +H  R  GKQ F+++R    +VQCI  VG+ ISK MV F GNIPKES+++++   V V   +ESCT+ ++EL +E + V+S++K++LPLQIEDASRP+  ++      +VN DTRLD R  +LRT  NQAI  L   +   F   L  QGF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI +T   IFK L    A EI +V +Q+ ++ F+FLEP LIL F++GVAML EAG+E G+ EDL+T NEK+LG+L+K K+ TDFY+LDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  HGI    I  Y+ESF YGC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   51 DHAAGRYGLSEMIQSKDKRSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKFAGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531          

Query:  589 DTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLE---MQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI--EMGEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D +LD R+  +R      ++ +   +   F  +  ++G+ ++  P+++    EGG+ +F++KYF ++AYL QS QLY +  +      V+TIS+ +RAE S T RHL E+T ++ E   + F      +   +CD +  + K       +    + K+ N +     +P   +N+ + +  L E  +  + G F    ED+    E             +  +L +FP  ++ FY     +    + S D  +    EI+ G+ R++D   L +   + GI       Y +   YG  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:  237 DVQLDNRHIMIRGENTSKVLKMRSVVTQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLP-ALGDVFTISQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLK-------SPWGYLVKELNPDFKPPQKPFRRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPE-----RKMTDTINEPIMLCRFPAEIKSFYMQRCKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTMPHGGYGLGLERFLCWLLNRYHIREVCLYPRFLDRCRP 558          

Query:  589 DTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLE---MQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI--EMGEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D +LD R+  +R      ++ +   +   F  +  ++G+ ++  P+++    EGG+ +F++KYF ++AYL QS QLY +  +      V+TIS+ +RAE S T RHL E+T ++ E   + F      +   +CD +  + K       +    + K+ N +     +P   +N+ + +  L E  +  + G F    ED+    E             +  +L +FP  ++ FY     +    + S D  +    EI+ G+ R++D   L +   + GI       Y +   YG  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:  237 DVQLDNRHIMIRGENTSKVLKMRSVVTQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLP-ALGDVFTISQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLK-------SPWGYLVKELNPDFKPPQKPFRRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPE-----RKMTDTINEPIMLCRFPAEIKSFYMQRCKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTMPHGGYGLGLERFLCWLLNRYHIREVCLYPRFLDRCRP 558          

Query:  199 SFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNN---LAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            + V +  +    A + + ++  +H  R  GKQ F+V+R   ++VQ +  VG++ SK MV F  NI KES+++VE  V  VE+ +ESC+Q  VEL +E + V+S+S++RLPLQ+EDA RP+ + +    A VN DTRLD R  +LRT T+QAI  L   +   F   L ++GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I     KV+ +  VFRAE+SNTHRHLTEF GLD+EM FS HYHEV+ +I DTMV IFK L      EI  V KQ+  EPF+FLEPTL L + EG+AML  AG+EMG+ EDL+T NEK+LG+L+K+K+ TDFYVLDK+PLAVRPFYTMPD     +SNSYD FMRGEEI+SGAQR+HD  +L E A+ H I L+ IK Y++SF YG  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   74 ALVRVQDLTLEKAEQQIWVRARIHTSRAKGKQCFLVLRHQQFTVQALLAVGDRASKQMVKFAANITKESIIDVEAVVKKVEQKIESCSQQDVELHVERIFVISQSEARLPLQLEDAVRPEGEGDEEGRATVNQDTRLDNRVIDLRTTTSQAIFRLQSGVCQLFRDTLINKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGLDIEMAFSYHYHEVIDSITDTMVQIFKGLRDRFQTEIQTVNKQYPSEPFKFLEPTLRLEYKEGLAMLRAAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPSNLKYSNSYDMFMRGEEILSGAQRIHDAQLLTERAMHHNIDLEKIKAYIDSFRYGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 531          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQA-FMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLI---LNFSEGVAMLNEAGIEM--GEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E++  + V + G++H++R+ GK   F+V+RD    +QC+        KL   + G +      E    +    KPV    Q+    ++                +  A     DN L  + ++D +L+ R+  +R      I+ +   +   F  +  S+G+ +I  P+++    EGG+ +F + YF + AYL QS QLY +  I       + I++ +RAE S T RHL+E+T ++ E  F   Y ++L+ + D +  +   + K+ AA +      ++I P +F  P      +N++E +  L E  I+   G F    ED+    E      +      +  +L +FP  ++ FY     +    + S D  M    EI+ G+ R+ D   L E   + GI       Y +  ++G  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:  129 EALREQRVKVFGWVHRLRRQGKNLLFIVLRDGTGFLQCVL-----TDKLCQCYNGLV---LSTESSVALYGTVKPVPEGKQAPGGHELHCDFWEL---------VGLAPAGGADNLLNEESDVDVQLNNRHMMIRGENVSKILKVRSAVTQCFRDHFFSRGYCEITPPTLVQTQVEGGSTLFGLNYFGENAYLTQSSQLYLETCIP-ALGDTFCIAQSYRAEQSRTRRHLSEYTHIEAECPFM-SYEDLLNRLEDLVCDVVDRVLKSPAAPLL-----YDINP-DFKPPKRPFKRMNYTEAIDWLKEHNIKKDDGTFYEFGEDIPEAPE-----RLMTDSINETILLCRFPAEIKSFYMQRCPEDRRLTESVDVLMPNVGEIVGGSMRIWDSDELLEGYKREGIDPTPYYWYTDQRKFGTCPHGGYGLGLERFLTWLLNRHHIRDVCLYPRFIQRCRP 556          

Query:  604 YRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDK------------AYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTL-----ILNFSEGVAMLNEAG------IEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNS-YDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            + +   RT    +++ +  +      S+ R  G+  I+ P I S   EG   +F+V+   DK            AYL  S QL+ ++ + G    VYT    FRAENS + RHL EF  ++ E+ F+    +++  + D      + +  N   ++    K       E ++P L     +++++E + +L  +        E G   DL T +EK L K       T  +V++ +P  ++PFY   + D+P  + +  D  + G  E+  G+ R     +L +   + G++ DT   YL+  E+G  PH G G+G ER +   LGL+NI+    F R
Sbjct:  149 FPHLRCRTNAFSSMLRIRSEATAAIQSFFRDHGYVQIHTPVITSNDCEGAGELFQVEPTGDKKDSDDPHFFSVPAYLTVSGQLHLEV-MAGAFSAVYTFGPTFRAENSQSRRHLAEFYMVEAEIAFTESLDDLMKVMEDLFKAATEHVFSNCTEDVELFHKHVAPGHREQVDPMLNRKFNVISYTEAIDILKSSSQNFTFSPEWGC--DLQTEHEKFLVKHCGN---TPVFVVN-YPYELKPFYARDNQDHPRHTAAAVDLLVPGVGELCGGSLREERLHLLTQRLSQAGLE-DTYAWYLQLREFGSVPHGGFGMGFERYLQCILGLNNIKDAIPFAR 478          

Query:  589 DTRLDYRYFEL--RTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFND---KAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYH---EVLHTICDTMV-HI---FKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI---EMGEF-EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPL-AVRPFYTMPDADYP--------------GFSNSYDFFMRGEEIMSGAQRVHDPVMLRE------SAVKHGIKLDTIKD--YLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFP 1539
            +TR   RY +L       Q  +  +  I  Y  S+L   GF +I  P +        A  F + Y ND     Y+  +P+LY +M +VGG  +VY I R FR E  +   H  EFT  +  M ++  YH   E+   +   MV HI   +K     +  E  A +  F   PF  +  T  L    GV           EM +F +DL    E             D  V D   +  + P Y     D+P              G +  ++ F+  +EI +    ++DP+  RE       A   G       D  +  + EYG  P AG G+G++R+ M     +NI+ V +FP
Sbjct:  237 ETRFRQRYLDLILNDFVRQKFVTRSKIIT-YLRSFLDQLGFLEIETPMMNLIPGGAVAKPF-ITYHNDLNMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFYMAYA-DYHDLMEITEKLLSGMVKHITGAYKVTYHPDGPEGQAYEIDFT-PPFRRISMTQELEKELGVKFPPPDTYDSDEMRKFLDDLCVQKEVECPPPRTTARLLDKLVGDFLEVKCINPTYI---CDHPQIMSPLAKWHRSQKGLTERFELFVMKKEICNAYTELNDPIRQRELFEQQAKAKAEGDDEAMFIDETFCTALEYGLPPTAGWGMGIDRLTMFLTDSNNIKEVLLFP 584          

Query:  589 DTRLDYRYFEL--RTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFND---KAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYH---EVLHTICDTMV-HI---FKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI---EMGEF-EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPL-AVRPFYTMPDADYP--------------GFSNSYDFFMRGEEIMSGAQRVHDPVMLRE------SAVKHGIKLDTIKD--YLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFP 1539
            +TR   RY +L       Q  +  +  I  Y  S+L   GF +I  P +        A  F + Y ND     Y+  +P+LY +M +VGG  +VY I R FR E  +   H  EFT  +  M ++  YH   E+   +   MV HI   +K     +  E  A +  F   PF  +  T  L    GV           EM +F +DL    E             D  V D   +  + P Y     D+P              G +  ++ F+  +EI +    ++DP+  RE       A   G       D  +  + EYG  P AG G+G++R+ M     +NI+ V +FP
Sbjct:  151 ETRFRQRYLDLILNDFVRQKFVTRSKIIT-YLRSFLDQLGFLEIETPMMNLIPGGAVAKPF-ITYHNDLNMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFYMAYA-DYHDLMEITEKLLSGMVKHITGAYKVTYHPDGPEGQAYEIDFT-PPFRRISMTQELEKELGVKFPPPDTYDSDEMRKFLDDLCVQKEVECPPPRTTARLLDKLVGDFLEVKCINPTYI---CDHPQIMSPLAKWHRSQKGLTERFELFVMKKEICNAYTELNDPIRQRELFEQQAKAKAEGDDEAMFIDETFCTALEYGLPPTAGWGMGIDRLTMFLTDSNNIKEVLLFP 498          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNN---LAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A + V ++  +H  R  GKQ F+V+R   ++VQ +  VGE+ SK MV F  NI KES+V+VEG V  V++ +ESCTQ  VEL IE + V+S ++ RLPLQ+EDA RP+T+ +    A VN DTRLD R  +LRT T+QA+  L   +   F   L  +GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L ++EGVAML EAG+EMG+ EDL+T NEK+LG+L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHDP +L E A  H I L+ IK Y++SF +G  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   39 ADETVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGERASKQMVKFAANITKESIVDVEGVVRKVDQKIESCTQQDVELHIERIYVISAAEPRLPLQLEDAVRPETEGDEEGRATVNQDTRLDNRVIDLRTSTSQAVFGLQSGVCQLFRETLTQKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTLVQIFKGLQERFQTEIQTVCKQFPSEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPQDPKYSNSYDMFMRGEEILSGAQRVHDPQLLTERATHHAIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 484          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNN---LAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A + V ++  +H  R  GKQ F+V+R   ++VQ +  VGE+ SK MV F  NI KES+V+VEG V  V++ +ESCTQ  VEL IE + V+S ++ RLPLQ+EDA RP+T+ +    A VN DTRLD R  +LRT T+QA+  L   +   F   L  +GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L ++EGVAML EAG+EMG+ EDL+T NEK+LG+L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHDP +L E A  H I L+ IK Y++SF +G  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   86 ADETVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGERASKQMVKFAANITKESIVDVEGVVRKVDQKIESCTQQDVELHIERIYVISAAEPRLPLQLEDAVRPETEGDEEGRATVNQDTRLDNRVIDLRTSTSQAVFGLQSGVCQLFRETLTQKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTLVQIFKGLQERFQTEIQTVCKQFPSEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPQDPKYSNSYDMFMRGEEILSGAQRVHDPQLLTERATHHAIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 531          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNN---LAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A + V ++  +H  R  GKQ F+V+R   ++VQ +  VGE+ SK MV F  NI KES+V+VEG V  V++ +ESCTQ  VEL IE + V+S ++ RLPLQ+EDA RP+T+ +    A VN DTRLD R  +LRT T+QA+  L   +   F   L  +GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L ++EGVAML EAG+EMG+ EDL+T NEK+LG+L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHDP +L E A  H I L+ IK Y++SF +G  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   49 ADETVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGERASKQMVKFAANITKESIVDVEGVVRKVDQKIESCTQQDVELHIERIYVISAAEPRLPLQLEDAVRPETEGDEEGRATVNQDTRLDNRVIDLRTSTSQAVFGLQSGVCQLFRETLTQKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTLVQIFKGLQERFQTEIQTVCKQFPSEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPQDPKYSNSYDMFMRGEEILSGAQRVHDPQLLTERATHHAIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 494          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNN---LAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A + V ++  +H  R  GKQ F+V+R   ++VQ +  VGE+ SK MV F  NI KES+V+VEG V  V++ +ESCTQ  VEL IE + V+S ++ RLPLQ+EDA RP+T+ +    A VN DTRLD R  +LRT T+QA+  L   +   F   L  +GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L ++EGVAML EAG+EMG+ EDL+T NEK+LG+L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHDP +L E A  H I L+ IK Y++SF +G  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   60 ADETVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGERASKQMVKFAANITKESIVDVEGVVRKVDQKIESCTQQDVELHIERIYVISAAEPRLPLQLEDAVRPETEGDEEGRATVNQDTRLDNRVIDLRTSTSQAVFGLQSGVCQLFRETLTQKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTLVQIFKGLQERFQTEIQTVCKQFPSEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPQDPKYSNSYDMFMRGEEILSGAQRVHDPQLLTERATHHAIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 505          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNN---LAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A + V ++  +H  R  GKQ F+V+R   ++VQ +  VGE+ SK MV F  NI KES+V+VEG V  V++ +ESCTQ  VEL IE + V+S ++ RLPLQ+EDA RP+T+ +    A VN DTRLD R  +LRT T+QA+  L   +   F   L  +GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L ++EGVAML EAG+EMG+ EDL+T NEK+LG+L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHDP +L E A  H I L+ IK Y++SF +G  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   63 ADETVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGERASKQMVKFAANITKESIVDVEGVVRKVDQKIESCTQQDVELHIERIYVISAAEPRLPLQLEDAVRPETEGDEEGRATVNQDTRLDNRVIDLRTSTSQAVFGLQSGVCQLFRETLTQKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVDEIADTLVQIFKGLQERFQTEIQTVCKQFPSEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPQDPKYSNSYDMFMRGEEILSGAQRVHDPQLLTERATHHAIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 508          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTD---NNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A  +V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+++VEG V  V + + SCTQ  VEL ++ + V+S ++ RLPLQ++DA RP+ +   +  A VN DTRLD R  +LRT T+QAI  L   I   F   L ++GF +I  P IISAASEGGANVF V YF + AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L + E +AML EAG+EM + EDL+T NEK+LG+L+K+K+ TDFYVLDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQR+HDP +L E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:   56 ADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI--EMGEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E    + V + G++H++R+ GK   F+V+RD    +QC+      +S  +      +   +   V     L   P         EL  +  ++         + +  A   D   N  + ++D +L+ R+  +R      I+     I   F  +   +G+ ++  P+++    EGGA +F++ YF ++A+L QS QLY +  +      V+ I++ +RAE S T RHL EFT ++ E  F   + ++L+ + D +  +   + K+  A I   +   N +P +   P   +N+S+ +  L E  +  E G F    +D+    E      +      +  +L +FP+ ++ FY     + P  + S D  M    EI+ G+ R  D   + E   + GI       Y +  +YG  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:   70 EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCV------LSDDLCQCYNGVVLSTESSVAVYGTLNLTPKGKQAPGGHELSCDFWEL---------VGLAPAGGADNLIN-EESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRGYCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLP-ALGDVFCIAQSYRAEQSRTRRHLAEFTHVEAECPFL-TFEDLLNRLEDLVCDVVDRVLKSPVASI-VYELNPNFKPPK--RPFRRMNYSDAIEWLKEHDVKKEDGTFYEFGDDIPEAPE-----RLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQRKYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP 497          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI--EMGEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E    + V + G++H++R+ GK   F+V+RD    +QC+      +S  +      +   +   V     L   P         EL  +  ++         + +  A   D   N  + ++D +L+ R+  +R      I+     I   F  +   +G+ ++  P+++    EGGA +F++ YF ++A+L QS QLY +  +      V+ I++ +RAE S T RHL EFT ++ E  F   + ++L+ + D +  +   + K+  A I   +   N +P +   P   +N+S+ +  L E  +  E G F    +D+    E      +      +  +L +FP+ ++ FY     + P  + S D  M    EI+ G+ R  D   + E   + GI       Y +  +YG  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:  131 EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCV------LSDDLCQCYNGVVLSTESSVAVYGTLNLTPKGKQAPGGHELSCDFWEL---------VGLAPAGGADNLIN-EESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRGYCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLP-ALGDVFCIAQSYRAEQSRTRRHLAEFTHVEAECPFL-TFEDLLNRLEDLVCDVVDRVLKSPVASI-VYELNPNFKPPK--RPFRRMNYSDAIEWLKEHDVKKEDGTFYEFGDDIPEAPE-----RLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQRKYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP 558          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI--EMGEF----EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E    + V + G++H++R+ GK   F+V+RD    +QC+      +S  +      +   +   V     L   P         EL  +  ++         + +  A   D   N  + ++D +L+ R+  +R      I+     I   F  +   +G+ ++  P+++    EGGA +F++ YF ++A+L QS QLY +  +      V+ I++ +RAE S T RHL EFT ++ E  F   + ++L+ + D +  +   + K+  A I   +   N +P +   P   +N+S+ +  L E  +  E G F    +D+    E      +      +  +L +FP+ ++ FY     + P  + S D  M    EI+ G+ R  D   + E   + GI       Y +  +YG  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:  132 EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCV------LSDDLCQCYNGVVLSTESSVAVYGTLNLTPKGKQAPGGHELSCDFWEL---------VGLAPAGGADNLIN-EESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRGYCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLP-ALGDVFCIAQSYRAEQSRTRRHLAEFTHVEAECPFL-TFEDLLNRLEDLVCDVVDRVLKSPVASI-VYELNPNFKPPK--RPFRRMNYSDAIEWLKEHDVKKEDGTFYEFGDDIPEAPE-----RLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQRKYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP 559          

Query:  601 DYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVK-----------YFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFK---ELEKNNAAEIAAVKKQF----NIEPFEFLEPT--LILNFSEGVAMLNEAGIEMGEFE----DLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFS-NSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
             Y +   RT    +I+ +  +      SY +  GF  I+ P + S   EG   +F+V+           +F+  A+L  S QL+ ++ + G   +V+T    FRAENS + RHL EF  ++ E+ F     E L  +   M  +FK   E+  ++  E   +  QF         E +     LI++++E + +L +A            DL T +EK L +          +V++ +P  ++PFY   + D P  +  + D  + G  E+  G+ R     +L +   + G+     + YL+  ++G  PH G G+G ER +   LG+DNI+ V  FPR
Sbjct:  141 QYPHLRCRTNALGSILRVRSEATAAIHSYFKDNGFVHIHTPVLTSNDCEGAGELFQVEPSSKIKGPKESFFDVPAFLTVSGQLHLEV-MSGAFTQVFTFGPTFRAENSQSRRHLAEFYMVEAEISFV----ESLQDLMQVMEELFKATTEMVLSHCPEDVELCHQFIAAGQKGRLEHMLKNNFLIISYTEAIEILKQASQNFAFTPKWGVDLQTEHEKYLVRHCGN---IPVFVIN-YPSELKPFYMRENEDGPQNTVAAVDLLVPGVGELFGGSLREERYHVLEQRLARSGLT-KAYQWYLDLRKFGSVPHGGFGMGFERYLQCILGVDNIKDVIPFPR 470          

Query:  202 FVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDN---NLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
             V I+ +    A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+V+VEG V  V + + SCTQ  VEL ++ + V+S ++ RLPLQ++DA RP+ +      A VN DTRLD R  +LRT T+QAI  L   I   F   L ++GF +I  P IISAASEGGANVF V YF + AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L+K    EI  V KQF  EPF+FLEPTL L + E +AML EAGIEMG+ EDL+T NEK+LG+L+K+K+ TDFY+LDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQR+HDP ++ E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:   45 LVRISDLTVQKAGEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISSAEPRLPLQLDDAVRPEVEGEEEGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHPFRETLTNKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQKRFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGIEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLVTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501          

Query:  196 ISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASR---------PDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            ++F+++  +N S A+K V ++G +H  R  GK  F+V+R  +Y+VQ   ++ EKISK M+ F+ +I KES+V+V  T+  V+ P+ESCTQ  VEL  + V VVS S  +LPLQIEDASR          + +N LA VNLDTRLD R  +LRT T+ AI  +   I   F + L  +GF +I  P IISA SEGGANVFEV YF   AYLAQSPQLYKQMAI G  +KVYTI  VFRAE+SNTHRH+TEF GLDLEM F+ HYHEV+ TI + +  +FK L++N   EIAAV  Q+  EPF+F EP LIL + + + +L E GIE+G+ +DL+T  EK LGKL+K+K+ TDFYVLDKFPL+VRPFYTMPDA    +SNSYD FMRGEEI+SGAQR+HD  ML E A  H + L  I+ Y++SF+YGC PHAGGGIGLERV ML+LGL NIR  S+FPRDP RLTP
Sbjct:   67 LNFLKVKEINVSNATKDVWVRGRIHTTRSKGKNCFLVLRQGVYTVQVAMFMNEKISKQMLKFVSSISKESIVDVYATINKVDNPIESCTQKDVELLAQQVFVVSTSAPKLPLQIEDASRRAPTDEEKASEQENQLAVVNLDTRLDNRVIDLRTPTSHAIFRIQAGICNQFRNILDVRGFVEIMAPKIISAPSEGGANVFEVSYFKGSAYLAQSPQLYKQMAIAGDFEKVYTIGPVFRAEDSNTHRHMTEFVGLDLEMAFNFHYHEVMETIAEVLTQMFKGLQQNYQDEIAAVGNQYPAEPFQFCEPPLILKYPDAITLLRENGIEIGDEDDLSTPVEKFLGKLVKEKYSTDFYVLDKFPLSVRPFYTMPDAHDERYSNSYDMFMRGEEILSGAQRIHDADMLVERAKHHQVDLAKIQSYIDSFKYGCPPHAGGGIGLERVTMLFLGLHNIRLASLFPRDPKRLTP 531          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTD---NNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+++VEG V  V + + SCTQ  VEL ++ + V+S ++ RLPLQ++DA RP+ +   +  A VN DTRLD R  +LRT T+QAI HL   I   F   L ++GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L + E +AML EAG+EM + EDL+T NEK+LG+L+K+K+ TDFYVLDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQR+HDP +L E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:   56 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGIVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRIIDLRTSTSQAIFHLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKSNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTD---NNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A  +V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+++VEG V  V + + SCTQ  VEL ++ + V+S ++ RLPLQ++DA RP+ +   +  A VN DTRLD R  +LRT T+QAI  L   I   F   L ++GF +I  P IISAASEGGANVF V YF + AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DT+V IFK L++    EI  V KQF  EPF+FLEPTL L + E +AML EAG+EM + EDL+T NEK+LG+L+K+K+ TDFYVLDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQR+HDP +L E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:   56 ADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDA---SRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG+  SK MV F  NI KES+V+VEG V  V + +ESCTQ  VEL ++ + V+S ++ RLPLQ++DA        +   A VN DTRLD R  +LRT T+QA+  L   I   F   L ++GF +I  P IISAASEGGANVF V YF + AYLAQSPQLYKQM I    +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+  I DTMV IFK L++    EI  V KQF  EPF+FLEPTL L + E +AML EAG+EMG+ +DL+T NEK+LG LIK+K+ TDFY+LDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQR+HDP +L E A+ HGI L+ IK Y++SF +G  PHAGGGIGLERV ML+LGL N+R+ SMFPRDP RLTP
Sbjct:   56 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIESCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLIKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501          

Query:  139 DQSVGKYGDAKL----EPFNSNSISFVEIN-LVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRP----DTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D S G+YG A L    E F      FV +N L   +   ++V ++G +H  R  GKQ F+V+R    +VQCI  VGE+ISK MV F GN+ +ES+++V+  VV V   +ESCT+ T+EL IE + VVS++K +LPLQIEDASRP    D D+   +VN DTRLD R  +LRT  NQAI  L   +   F   L  +GF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI DT   IFK L  N + EIAAV +Q+N+EPF+FLEP LIL F+EGV ML EAG+E G+ EDL+T NEK+LG+L+K K+ TDFYVLDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  H I    I  Y+ESF +GC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   58 DVSAGRYGSAGLIQSKEKFEERK--FVPVNELSQPAHRDQLVWVRGRVHTSRSKGKQCFLVLRQQSSTVQCILAVGERISKQMVKFSGNVSRESIIDVQAKVVSVPNKIESCTEQTIELCIEQLFVVSQAKPQLPLQIEDASRPENLDDADSLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTVKGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIADTFTGIFKGLRDNYSQEIAAVNQQYNVEPFKFLEPPLILEFAEGVKMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYVLDKFPLAIRPFYTMPDPNNPMYSNSYDMFMRGEEILSGAQRIHDPDFLMERAKHHAIDTSKIAAYIESFRFGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 539          

Query:  139 DQSVGKYGDAKL----EPFNSNSISFVEIN-LVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASR---PDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D S G+YG A L    E F      FV ++ L   +   ++V ++G +H  R  GKQ F+V+R    +VQCI  VGE+ISK MV F GN+ +ES+++V+  VV V   +ESCT+ TVEL IE + VVS++K +LPLQIEDASR   PD  ++L  +VN DTRLD R  +LRT  NQAI  L   +   F   L ++GF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI DT   IFK L    +AEIAAV +QF +EPF+FLEP LIL F+EGV ML EAG+E G+ EDL+T NEK+LG+L+K K+ TDFYVLDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  H I    I  Y+ESF +GC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   58 DVSAGRYGSAGLIQSKEKFEDRK--FVSVSELSQPTCRDQLVWVRGRVHTSRSKGKQCFLVLRQQSSTVQCILAVGERISKQMVKFSGNVSRESIIDVQAKVVSVPNKIESCTEQTVELCIEQLFVVSQAKPQLPLQIEDASRAENPDDADSLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTTKGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIADTFTGIFKGLRDTYSAEIAAVNQQFKVEPFKFLEPPLILEFAEGVQMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYVLDKFPLAIRPFYTMPDPNNPMYSNSYDMFMRGEEILSGAQRIHDPDFLIERAKHHAIDTSKIAAYIESFRFGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 539          

Query:  139 DQSVGKYGDAKL----EPFNSNSISFVEIN-LVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASR---PDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D S G+YG A L    E F      FV ++ L   +   ++V ++G +H  R  GKQ F+V+R    +VQCI  VG++ISK MV F GN+ +ES+++V+  VV V   +ESCT+ T+EL IE + VVS++K +LPLQIEDASR   PD  ++L  +VN DTRLD R  +LRT  NQAI  L   +   F   L ++GF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI DT   IFK L  + +AEIAAV +QF +EPF+FLEP LIL F+EGV ML EAG+E G+ EDL+T NEK+LG+L+K K+ TDFYVLDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  H I    I  Y+ESF +GC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   58 DVSAGRYGSAGLIQSKEKFEDRK--FVSVSELSQPAYRDQLVWVRGRVHTSRSKGKQCFLVLRQQSSTVQCILAVGDRISKQMVKFSGNVSRESIIDVQAKVVSVPNKIESCTEQTIELCIEQLFVVSQAKPQLPLQIEDASRAENPDDADSLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTAKGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIADTFTGIFKGLRDSYSAEIAAVNQQFKVEPFKFLEPPLILEFAEGVQMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYVLDKFPLAIRPFYTMPDPNNPMYSNSYDMFMRGEEILSGAQRIHDPDFLLERAKHHAIDTSKIAAYIESFRFGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 539          

Query:  139 DQSVGKYGDAKL--EPFNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLA----KVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D +  +YG +++       +   FV ++ +N  +   +V ++G +H  R  GKQ F+++R    +VQCI  VG+ ISK MV F GNIPKES+++++   V V   +ESCT+  +EL +E + V+S++K++LPLQIEDASRP+  ++      +VN DTRLD R  +LRT  NQAI  L   +   F   L  +GF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KVYT+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI +T   IFK L    + EI AV +Q+ +EPF+FLEP LIL F+EGVAML EAGIE G+ EDL+T NEK+LG+L+K K+ TDFY+LDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  HGI +  I  Y+ESF YGC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   53 DHAAARYGLSEMIQSKDKRSEREFVTVSDLNAHVGKGLVWVRGRVHTTRAKGKQCFLILRQQSSTVQCILAVGDIISKQMVKFAGNIPKESIIDIQAKAVAVPTKIESCTEQLLELSVEQIFVISQAKAQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEKGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTAIFKGLRDKYSREIEAVGQQYKVEPFKFLEPPLILQFAEGVAMLREAGIETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPMYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGIDITKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 533          

Query:  139 DQSVGKYGDAKL----EPFNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPD----TDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D S G+YG A++    E +      F+ I  +N+ I    + ++G +H  R  GKQ F+++R    +VQCI  VG+  SK MV F GNI KES++++E   V V   +ESCT+  +EL I+ + VVS++K++LPLQIEDASRPD    TD    +VN DTRLD R  +LRT  NQAI  L   +   F   L  +GF +I+ P IISAASEGGANVF V YF D AYLAQSPQLYKQMAI     KV+T+  VFRAE+SNTHRHLTEF GLDLEM F  HYHEVLHTI +T   +FK L    A+EI AV++QF++EPF+FLEP L+L FSEGVAML EAGIE G+ EDL+T NEK+LG+L+K K+ TDFY+LDKFPLA+RPFYTMPD + P +SNSYD FMRGEEI+SGAQR+HDP  L E A  HGI ++ I  Y+ESF +GC PHAGGGIG+ERVVMLYLGLDNIR+ SMFPRDP RLTP
Sbjct:   57 DCSEGRYGIAEIIMSKEKYEDRH--FMAIGNLNQCIGKAPIWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDNTSKQMVKFAGNIHKESIIDIEAKAVAVPNKIESCTEQNLELVIQQLFVVSQAKAQLPLQIEDASRPDSLDDTDALNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEKGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVFTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGETFTAMFKGLRDRYASEIEAVRQQFDVEPFKFLEPPLVLKFSEGVAMLREAGIETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSGAQRIHDPEFLTERAKHHGIDINKIAAYIESFRFGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 537          

Query:  199 SFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDN---NLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTM 990
            + V +  +    A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG++ SK MV F  NI KES+V+           +ESC+Q  VEL IE + V+S++++RLPLQ+EDA RPD D      A VN DT+LD R  +LRT T+QAI  L   +   F   L ++GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I     KV+ +  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+ +I DTM
Sbjct:   17 TLVRVQDLTTQKAGQLVWVRARIHTSRAKGKQCFLVLRQQQFNVQALVAVGDRASKQMVKFAANITKESIVD-----------IESCSQQDVELHIERIYVISQAEARLPLQLEDAVRPDADGEEEGRATVNQDTKLDNRVIDLRTTTSQAIFRLQSGVCQLFRDTLINKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVIDSITDTM 272          

Query: 1216 TDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            TDFYVLDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHD  +L E A  HGI L+ IK Y++SF YG  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:  275 TDFYVLDKYPLAVRPFYTMPDPSNPKYSNSYDMFMRGEEILSGAQRVHDAQLLTERATHHGIDLEKIKAYIDSFRYGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 390          

Query:  199 SFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDN---NLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTM 990
            + V +  +    A ++V ++  +H  R  GKQ F+V+R   ++VQ +  VG++ SK MV F       +     G    VE+ +ESC+Q  VEL IE + V+S++++RLPLQ+EDA RPD D      A VN DT+LD R  +LRT T+QAI  L   +   F   L ++GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I     KV+ +  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+ +I DTM
Sbjct:   17 TLVRVQDLTTQKAGQLVWVRARIHTSRAKGKQCFLVLRQQQFNVQALVAVGDRASKQMVKF-------AHRGRGGGGAPVEQKIESCSQQDVELHIERIYVISQAEARLPLQLEDAVRPDADGEEEGRATVNQDTKLDNRVIDLRTTTSQAIFRLQSGVCQLFRDTLINKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVIDSITDTM 276          

Query: 1216 TDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            TDFYVLDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHD  +L E A  HGI L+ IK Y++SF YG  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:  279 TDFYVLDKYPLAVRPFYTMPDPSNPKYSNSYDMFMRGEEILSGAQRVHDAQLLTERATHHGIDLEKIKAYIDSFRYGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 394          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQA-FMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLI---LNFSEGVAMLNEAGIEMG-----EF-EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E +  + V + G++H++R+ GK   F+V+RD    +QC+        KL   + G +      E    +    KPV    Q+    ++                I  A     DN L  + ++D +L+ R+  +R      I+ +   +   F  +  S+G+ +I  P+++    EGG+ +F++ YF ++AYL QS QLY +  +       + I++ +RAE S T RHL+E+T ++ E  F   Y ++L+ + D +  +   + K+ AA +      ++I P +F  P      +N++E +  L E  I+       EF ED+    E      +      +  +L +FP  ++ FY     +    + S D  M    EI+ G+ R+ D   L E   + GI       Y +  ++G  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:  132 EPLREQRVKVFGWVHRLRRQGKNLLFIVLRDGTGFLQCVL-----TDKLCQCYNGLV---LSTESTVALYGTVKPVPEGKQAPGGHELHCDFWEM---------IGLAPAGGADNLLNEESDVDVQLNNRHMMIRGENVSKILRVRSTVTQCFRDHFFSRGYYEITPPTLVQTQVEGGSTLFKLDYFGEQAYLTQSSQLYLETCLP-ALGDTFCIAQSYRAEQSRTRRHLSEYTHIEAECPFM-SYEDLLNRLEDLVCDVVDRVLKSPAAALL-----YDINP-DFKPPKRPFKRMNYTEAIEWLKEHDIKKDDGTYYEFGEDIPEAPE-----RLMTDSINETILLCRFPAEIKSFYMQRCQEDRRLTESVDVLMPNVGEIVGGSMRIWDADELLEGYKREGIDPTPYYWYTDQRKFGSCPHGGYGLGLERFLTWLLNRHHIRDVCLYPRFIQRCRP 559          

Query:  226 ESIASKIVTIKGFLHQVRKTGKQA-FMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLI---LNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            E +  + V + G++H++R+ GK   F+V+RD    +QC+        KL   + G +      E    +    KPV    Q+    ++                I  A     DN L  + ++D +L+ R+  +R      I+ +   +   F  +  S+G+ +I  P+++    EGG+ +F++ YF ++AYL QS QLY +  +       + I++ +RAE S T RHL+E+T ++ E  F   Y ++L+ + D +  +   + K+ AA +      ++I P +F  P      +N++E +  L E  I+    +D  T  E             +  +++     V   +   D   P             EI+ G+ R+ D   L E   + GI       Y +  ++G  PH G G+GLER +   L   +IR V ++PR   R  P
Sbjct:   70 EPLREQRVKVFGWVHRLRRQGKNLLFIVLRDGTGFLQCVL-----TDKLCQCYNGLV---LSTESTVALYGTVKPVPEGKQAPGGHELHCDFWEM---------IGLAPAGGADNLLNEESDVDVQLNNRHMMIRGENVSKILRVRSTVTQCFRDHFFSRGYYEITPPTLVQTQVEGGSTLFKLDYFGEQAYLTQSSQLYLETCLP-ALGDTFCIAQSYRAEQSRTRRHLSEYTHIEAECPFM-SYEDLLNRLEDLVCDVVDRVLKSPAAALL-----YDINP-DFKPPKRPFKRMNYTEAIEWLKEHDIK----KDDGTYYEFGEVCAPLHL---NINIMNIVCFCVS-LWGQVDVLMPNVG----------EIVGGSMRIWDADELLEGYKREGIDPTPYYWYTDQRKFGSCPHGGYGLGLERFLTWLLNRHHIRDVCLYPRFIQRCRP 477          

Query:  604 YRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVK--------------YFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTL-----ILNFSEGVAMLNEAG---IEMGEFE-DLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFS-NSYDFFMR-GEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            Y +   RT    +++ +  +      SY R  GF  I+ P I S   EG   +F+V+              +F+  +YL  S QL+ ++ + G    VYT    FRAENS + RHL EF  ++ E+ F+    ++L  + D +    + L  + A ++    K  +    E ++  L     +++++E + +L  +    I   E+  DL T +E     L+K       +V D +P  ++PFY   + D P  +  + D  +    E+  G+ R   P +L+      G++ +T   YL+  E+G  PH G G+G ER +   LG+DNI+    F R
Sbjct:  149 YPHLRCRTNAFSSLLRIRSEATSAIHSYFRDNGFVQIHTPIITSNDCEGAGELFQVEPAGNEHSSDKENPHFFSVPSYLTVSGQLHLEV-MAGAFPAVYTFGPTFRAENSQSRRHLAEFYMVEAEISFTESLEDLLKLMEDLLKTSTEHLLSHCAEDVELFHKYVSPGHREKVDLILKRKFNVISYTEAIDILKRSSQQFIYKPEWGCDLQTEHE---KFLVKHCGDVPVFVTD-YPYDLKPFYARDNQDQPQHTAAAVDLLVPIVGELCGGSLREERPELLKTRLAGAGLE-ETYAWYLQLREFGSVPHGGFGMGFERYLQCVLGVDNIKDTIPFAR 480          

Query:  235 ASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTD---NNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            A + + ++  +H  R  GKQ F+V+R   ++VQ I  VG+ +SK MV F  +I KES+V+VEG V  V++ +ESCTQ  VEL IE + VVS S  +LPLQ++DA+RP+ D   +  A VN DTRLD R  +LRT T+QAI  L   +   F   L ++GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I G  +KV+ I  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+ +I DT+V IFK L+     EI  V +Q+  EPF+FLEP+L L F E +AML EAG+EMG+ EDL+T NEK+LG+L+K+K+ TDF++LDK+PLAVRPFYTMPD   P  SNSYD FMRGEEI+SGAQRVHDP +L E A  HGI L+ IK Y++SF YG  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   86 ADQKLWVRARVHTSRSKGKQCFLVLRQQQFNVQGIVAVGQNVSKQMVKFAASINKESIVDVEGFVRKVDQKIESCTQQDVELHIEQIFVVSMSDPKLPLQLDDATRPENDKEEDGRATVNQDTRLDNRILDLRTTTSQAIFRLQAGVCHLFRETLINKGFVEIQTPKIISAASEGGANVFTVTYFKTNAYLAQSPQLYKQMCISGDFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVESIGDTLVQIFKGLQTRYQTEIQTVGRQYPAEPFKFLEPSLRLEFPEALAMLREAGVEMGDEEDLSTPNEKLLGRLVKQKYDTDFFILDKYPLAVRPFYTMPDHRDPKTSNSYDMFMRGEEILSGAQRVHDPELLTERARHHGIDLEKIKAYIDSFRYGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFPRDPKRLTP 531          

Query:  523 LPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRS-QGFRDINCPSIISAASEGGANVFEVKYFNDKAY--LAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQF 945
            LP +I D           K +   R+ YRY +LR+   Q  +    D+      YL +  GF D+  P++    + GGA  F V       +  L QSPQ +KQ+ +VGG  + + I+R +R E S   R   EFT +D+EM F
Sbjct:  111 LPFEIHD---------FTKKSEALRMKYRYLDLRSSQMQHNLRTRSDMVMRMRDYLCNIHGFVDVETPTLFKR-TPGGAKEFVVPSREPGRFYCLPQSPQQFKQLLMVGGIDRYFQIARCYRDEGSKPDRQ-PEFTQVDIEMSF 243          

Query: 1306 YDFFMRGEEIMSGAQRVHDPVMLRESAVKHGI---KLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            YD  + G EI  G+ R+HD  +  +  V H +    ++ +   LE+ E G  PH G  +GL+R+V   +G  +IR V  FP+
Sbjct:  480 YDLVLNGSEIGGGSIRIHDAAL--QKHVLHDVLKEDVELLGHLLEALESGAPPHGGIALGLDRLVATVVGSASIRDVIAFPK 559          

Query:  589 DTRLDYRYFELRTITNQAIIH---LTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFND---KAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHT----ICDTMVHI---FKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGV-AMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKF------PLAVRPFYTMPDADYP--------------GFSNSYDFFMRGEEIMSGAQRVHDPVMLRE------SAVKHGIKLDTIKD--YLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFP 1539
            +TR   RY +L  I N  +     +   I  Y   +L S GF ++  P +   A    A  F + + ND     Y+  +P+LY +M +VGG  +VY I R FR E  +   H  EFT  +  M ++  Y++++      +   ++HI   FK +   +  E   V+  F   PF  L  +LI +    +   L  A     E   L      +   +      T   +LDK          V P +     D+P              G +  ++ F+  +E+++    ++DP+  R+      +A   G     + D  +  + EYG  P AG G+G++R+ M     +NI+ V +FP
Sbjct:  254 ETRYRQRYLDL--ILNDYVRQKFIVRAKIINYVRHFLDSLGFLEVETPMMNIIAGGAAARPF-ITHHNDLNMDLYMRIAPELYLKMLVVGGMDRVYEIGRQFRNEGIDL-THNPEFTTCEFYMAYA-DYNDLMEITEKLLSARVMHITGGFKIVLHPDGPEGEGVEVDFT-PPFRRL--SLIGDLERVLDTKLPAADTLSTEEARLAVDKLCVEKGVECPAPRTMARLLDKLVGEFLEVTCVNPTFI---CDHPQIMSPLAKWHRKVKGLTERFELFVMKKEVVNAYTELNDPLRQRQLFEEQANAKAAGDDEAMLIDETFCTALEYGLPPTAGWGMGIDRLTMFLTNSNNIKEVLLFP 601          

Query:  196 ISFVEINLVNESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEK--ISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAK---VNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLE--PTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDT--IKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            + FV+++   +S   K V  +  +H  R+ G   AF+ +R     +Q +    ++  ISK MV + G++  ES+V V G V  V++P++S T   +E+ I  +  +S +   LP+ +EDASR + +   A    VNLDTRLDYR  +LRT+TNQAI  +   +   F  YL ++ F +++ P ++ A SEGG++VFEV YF  KAYLAQSPQ  KQ  IV   ++VY I  VFRAENSNTHRH+TEFTGLD+EM F  HYHEVL T+ +  V IF EL K  A EI  V+KQ+ +E F+  +    + L + EG+ ML  AG E+G+FEDL+T NEK LGKL++ K+ TDFY+LDKFPL +RPFYTMPD   P +SNSYDFFMRGEEI+SGAQR+HD  +L+E    HG+  +   +KDY + F YGC PHAGGGIGLERVVM YL L NIRR S+FPRDP RL P
Sbjct:   94 VKFVDLDEAKDS--DKEVLFRARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISKNMVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNLEIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTNQAIFRIQAGVCELFREYLATKKFTEVHTPKLLGAPSEGGSSVFEVTYFKGKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSELPKRFAHEIELVRKQYPVEEFKLPKDGKMVRLTYKEGIEMLRAAGKEIGDFEDLSTENEKFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHDHALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFPRDPKRLRP 557          

Query:  247 VTIKGFLHQVRKTGKQAFMVIRDDIYSVQCI-----AWVGEKISKLM---VNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQI---EXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYV-LDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            V + G++H++R   K  F+V+RD    +QC+     A   + +   +   V   G I K               P        VEL +   E V +    +     +I + S P              LD R+  LR     A++ +   +          +   ++  P ++    EGG+ +F++ Y+ ++AYL QS QLY +  +      VYTI   FRAE S+T RHL+E+T ++ E+ F   + ++L  I   +V   + + ++  A    + KQ N        P + L + + +  LNE  I+  E ED    ++       K        + L +FP+ ++ FY    +D P  + S D  M    EI  G+ R+ D   L     + GI  D    +++  +YG  PH G GIG ER++        +R  S++PR   R  P
Sbjct:  132 VKVSGWIHRLRSNKKVIFVVLRDGSGFIQCVLSGDLALAQQTLDLTLESTVTLYGTIVKL--------------PEGKTAPGGVELNVDYYEVVGLAPGGEDSFTNKIAEGSDPSL-----------LLDQRHLALRGDALSAVMKVRAALLKSVRRVYDEEHLTEVTPPCMVQTQVEGGSTLFKMNYYGEEAYLTQSSQLYLETCL-ASLGDVYTIQESFRAEKSHTRRHLSEYTHIEAELAF-LTFDDLLQHIETLIVKSVQYVLEDPIA--GPLVKQLNPNFKAPKAPFMRLQYKDAITWLNEHDIKNEEGEDFKFGDDIAEAAERKMTDTIGVPIFLTRFPVEIKSFYMKRCSDDPRVTESVDVLMPNVGEITGGSMRIDDMDELMAGFKREGIDTDAYYWFIDQRKYGTCPHGGYGIGTERILAWLCDRFTVRDCSLYPRFSGRCKP 554          

Query:  622 RTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVK---------YFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKEL----------------EKNNAAEIAAVKKQFNIEP-FEFL--EPTLILNFSEGVAMLNEAGIEMGEF-------EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHD-PVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            RT    AI+ L   ++F F+ Y +   F  ++ P + S   EG   +F+V          YF    YL  S QL+ ++  +    + +T+S  FRAE S+T RHL+EF  L++EM F    +E+   +  T+ HI K                  E N ++E++  ++   I+  +E L  E    + ++  + +L +   E+  F       + L T +E     L  + F +  +V D +P   +PFY   ++        +D  + G  EI+ G+ R  D   + RE   +   +   +  Y+   + G +PH G G+G ER +    G  NI+    F R
Sbjct:  146 RTAYLSAILRLRSFVEFQFMLYFQKNHFTKVSPPILTSNDCEGAGELFQVSTNTSPTASSYFGKPTYLTVSTQLHLEILALS-LSRCWTLSPCFRAEKSDTPRHLSEFWMLEVEMCFVNSVNELTSFVETTIKHIIKACIDNQQELLPKQFISSQENNASSELSINQETQQIKTRWEDLINEKWHNITYTNAIEILKKRHNEVSHFKYEPKWGQPLQTEHE---KFLAGEYFKSPVFVTD-YPRLCKPFYMKQNSTPDDTVGCFDLLVPGMGEIIGGSLREDDYDKLCREMKARGMNRSGELDWYVSLRKEGSAPHGGFGLGFERFISYLYGNHNIKDAIPFYR 484          

Query:  529 LQIEDASRPDTDNNLAKVNLDTRL------DYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKA-------YLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEK 1017
            +Q+ED +  +  N       D +L      ++RY +LR    Q  +     I     +   +  F ++  P +  A  EG A  F V     ++        L QSPQ YKQ+ +  G  K Y ++R FR E+    R   EFT +D+EM F+ +  +V+  I  T+  ++ +  K
Sbjct:  120 VQLEDITVLNASNKKPAQMQDFKLSAIYPPEFRYLQLRNPKYQDFLKKRSSISKEIRNSFNNFDFTEVETPMLFKATPEG-AREFLVPTRTKRSDGKPSFYALDQSPQQYKQLLMASGVNKYYQMARCFRDEDLRADRQ-PEFTQVDMEMAFA-NSEDVMKIIEKTVSGVWSKFSK 292          

Query: 1306 YDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDY----LESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            YD  + G E+  G+ R+HDP  L++   +  +K+D   +     L +F+ G  PHAG  IG +R+  +    ++IR V  FP+
Sbjct:  545 YDLVVNGVELGGGSTRIHDP-RLQDYIFEDILKIDNAYELFGHLLNAFDMGTPPHAGFAIGFDRMCAMICETESIRDVIAFPK 626          

Query:  172 LEPFNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            L+     S  ++++  + E +  K V ++  +H  R TGKQ FM +RD  Y+VQ +    + +SK MV F   I +ES+++VEG V    + ++SC+Q  VE+ ++ + V+S S+ RLPLQIEDASRP+TD  LA VN DTRLD R  +LRT+ NQAI  +   +   F  +L S+GF +I+ P IISAASEGGANVFEV YF  KA+LAQSPQLYKQMA+ G   KVYTI  VFRAE+SNTHRHLTEF GLD+EM F  HYHEV+ TI D   +IFK L++  A +IA V+KQ+  EPF+FLEP LIL + EGV ML EAGIEMG  EDL+T NEK LGKL+K+K+ TDF++LDK+PL +RPFYTMPD   P  SNSYD F+RGEE++SGAQR+HDP  L+E A  HGI L+TIK Y++SF YG  PHAGGGIGL RVVMLYL L N+R+ SMFPRDP R+TP
Sbjct:   44 LQSKEKTSRQWLKVQALTEDMVGKRVLVRARIHTSRATGKQCFMTLRDRQYTVQALCAASDVVSKHMVKFAAGINRESIIDVEGEVKAAAQKIKSCSQQDVEILVDKLFVISLSEPRLPLQIEDASRPETDE-LAHVNQDTRLDNRIIDLRTVPNQAIFSIEAGVCKLFREFLDSKGFHEIHTPKIISAASEGGANVFEVSYFKGKAFLAQSPQLYKQMALTGDFDKVYTIGSVFRAEDSNTHRHLTEFIGLDVEMSFYEHYHEVVRTIGDMFNYIFKGLQERYAEDIAKVQKQYPSEPFKFLEPALILEYREGVDMLREAGIEMGYEEDLSTPNEKFLGKLVKQKYDTDFFILDKYPLCIRPFYTMPDPFNPNVSNSYDMFIRGEEVLSGAQRIHDPEKLKERASHHGIDLETIKSYIDSFRYGAPPHAGGGIGLARVVMLYLDLHNVRKSSMFPRDPKRITP 506          

Query:  586 LDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQ--FNIEPFEFLEPTLILNFSEGVAMLNEAGIEMG-EFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            +DT+LD R+  LR  T   I+ +   +   F  +   +G+ ++  P ++    EGG+ +F+  YF + A+L QS QLY + AI      V+ I+  +RAE S T RHL E   L + +        ++   C  +  + K     +     +++ +         FL   L   FS  ++ +N     +     D+    E             +  +L +FP+ ++ FY     D    + S D  M G  EI+ G+ R+     L E   + GI       Y +  +YG  PH G G+GLER +   L   +IR V  +PR   R  P
Sbjct:  244 IDTQLDNRHIMLRGETLAKILRMRSVVTHCFREHYFDRGYVELTPPCMVQTQVEGGSTLFKFNYFGEDAFLTQSSQLYLETAI-PALGDVFCIAESYRAEQSRTRRHLAETFDLLIYLGTRPESCNIVAIYCQAINQVLKSHIPCSFCTDLSLRPRPVHKACRLRFLSTAL---FSRLISSINSETFTLKIRVNDIPEMPE-----RKMTDQINEPILLCRFPVEIKSFYMQKCDDDRRLTESVDLLMPGVGEIIGGSMRMWKYDELIEGYKREGIDPAPYFWYTDQRKYGSCPHGGYGLGLERFLTWLLNRQHIRDVCFYPRFVGRCQP 564          

Query: 1309 DFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            D  M G  EI+ G+ R+     L E   + GI       Y +  +YG  PH G G+GLER +   L   +IR V  +PR   R  P
Sbjct:    2 DLLMPGVGEIIGGSMRMWKYDELIEGYKREGIDPAPYFWYTDQRKYGSCPHGGYGLGLERFLTWLLNRQHIRDVCFYPRFVGRCQP 87          

Query:  202 FVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPD---TDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
             V +  +    A +++ ++  +H  R  GKQ F+V+R   ++VQ +  VG++ SK MV F  NI KES+V+VE  V  VE+ +ESC+Q  VEL +E + V+S++++RLPLQ+EDA RPD    + + A VN DTRLD R  +LRT T+QA+  L   +   F   L  +GF +I  P IISAASEGGANVF V YF   AYLAQSPQLYKQM I     KV+ +  VFRAE+SNTHRHLTEF GLD+EM F+ HYHEV+ +I DTMV IFK L  N   EI  V KQF  EPF+FLEPTL L ++EGVAML EAG+EMG+ +DL+T NEK+LG+L+K+K+ TDFYVLDK+PLAVRPFYTMPD   P +SNSYD FMRGEEI+SGAQRVHD  +L E A  H I L+ IK Y++SF YG  PHAGGGIGLERV MLYLGL N+R+ SMFPRDP RLTP
Sbjct:   75 LVRVQDLTPEKADQLIWLRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDRASKQMVKFAANITKESIVDVEAAVRKVEQKIESCSQQDVELHVERIFVISQAEARLPLQLEDAVRPDGEGEEESRATVNQDTRLDNRVIDLRTTTSQAVFRLQSGVCQLFRDTLTKKGFVEIQTPKIISAASEGGANVFTVSYFKTSAYLAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVIESITDTMVQIFKGLRDNFQTEIQTVNKQFPSEPFKFLEPTLRLEYTEGVAMLREAGVEMGDEDDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPHNPKYSNSYDMFMRGEEILSGAQRVHDAQLLTERAQHHQIDLEKIKSYIDSFRYGAPPHAGGGIGLERVCMLYLGLHNVRQTSMFPRDPKRLTP 531          

Query:  205 VEINLVNESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNL-AKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLI---LNFSEGVAMLNEAGIEMG-----EF-EDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            V+I  + E    + V + G++H++R+ GK   F+V+RD    +QC+      +S  +      +   +   V     +   P         EL  +  ++           I  A     DN L  + ++D +L+ R+  +R      I+ +   +   F  +  S+G+ +I  P+++    EGG+ +F + YF ++AYL QS QLY +  I       + I++ +RAE S T RHL E+T ++ E  F   + ++L+ + D +  +   + K+ A ++      ++I P  F  P      +N++E +  L E  ++       EF ED+    E             +  +L +FP  ++ FY     +    + S D  M    EI+ G+ R+ D   L +   + GI       Y +  +YG  PH G G+GL+R +   L   +IR V ++PR   R  P
Sbjct:  126 VKIRHLEEKRGQR-VKVFGWVHRLRRQGKNLMFIVLRDGTGFLQCV------LSDKLCQCYNGLMLSTESSVVLYGTINAVPEGKQAPGGHELHCDFWEL-----------IGLAPAGGADNLLNEESDVDVQLNNRHMMIRGENVSKILRVRSTVTQCFRDHFFSRGYYEITPPTLVQTQVEGGSTLFNLNYFGEEAYLTQSSQLYLETCIP-ALGDTFCIAQSYRAEQSRTRRHLAEYTHIEAECPFIT-FEDLLNRLEDLVCDVVDRVLKSPAGQLL-----YDINP-NFQPPKRPFKRMNYTEAIEWLKEHDVKKDDGSYYEFGEDIPEAPE-----RQMTDAINETILLCRFPAEIKSFYMQRCPEDRRLTESVDVLMPNVGEIVGGSMRIWDSDELLDGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLDRFLTWLLNRHHIRDVCLYPRFIQRCRP 559          

Query:  607 RYFELRTITN--QAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVK-----------YFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFN--IEP--FEFLEPTL-----ILNFSEGVAMLNEAGIEMGEFE-----DLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFS-NSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            ++  LR  TN   +++ +  +      SY ++ GF  I+ P+I S   EG   +F+V+           +F+   YL  S QL+ ++ + G   +VYT    FRAENS + RHL EF  ++ E+ F+    E +  +   M  +F+ + ++  A        F+  + P   + L+  L     ++ ++E + +L  +  E   F      DL T +E     L+K       +V D +P  ++PFY   + D+P  +  + D  + G  E+  G+ R     +LR    + G++ DT   YL+   +G  PH G G+G ER +   LG+DNI+ V  FPR
Sbjct:  148 QFLHLRCRTNAFSSLLRIRSEATAAVHSYFKNNGFLLIHTPTITSNDCEGAGELFQVEPPGTTFANEGSFFSVPVYLTVSGQLHLEV-MSGAFPRVYTFGPTFRAENSQSRRHLAEFFMVEAEISFT----ESIEDLTKVMEELFRSVTESVLAHCEEDVDLFHKYVAPGHRDTLDDMLRKSFPVITYTEAIDILKRSS-ETFTFPTDWGCDLMTEHE---KFLVKHCGNIPVFVTD-YPYDLKPFYARDNQDHPKHTAAAVDLLVPGVGELCGGSLREERLDLLRSRLGECGLE-DTYSWYLDLRRFGSVPHGGFGLGFERYLQCILGVDNIKDVIPFPR 477          

Query:  577 KVNLDTRLDY--RYFELRTITN--QAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVK-----------YFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFN--IEPFEFLEPT-LILNFSEGVAMLNEAGIEMGEFE-----DLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNS-YDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            K+     L+Y  ++  LR  TN   +++ +  +      SY ++ GF  I+ P+I S   EG   +F+V+           +F+   YL  S QL+ ++ + G   +VYT    FRAENS + RHL EF  ++ E+ F+    E +  +   M  +F+ + ++  A        F+  + P   + P    + ++E + +L  +  E   F      DL T +EK L K          +V D +P  ++PFY   + D+P  + +  D  + G  E+  G+ R     +LR            + +YL+   +G  PH G G+G ER +   LG+DNI+ V  FPR
Sbjct:  114 KIKERHSLEYIRQFLHLRCRTNAFSSLLRIRSEATAAVHSYFKNNGFLLIHTPTITSNDCEGAGELFQVEPPGTTFANEGSFFSVPVYLTVSGQLHLEV-MSGAFPRVYTFGPTFRAENSQSRRHLAEFFMVEAEISFT----ESIEDLTKVMEELFRSVTESVLAHCEEDVDLFHKYVAPGHRVSPEGHSITYTEAIDILKRSS-ETFTFPTDWGCDLMTEHEKFLVKHCGN---IPVFVTD-YPYDLKPFYARDNQDHPKHTAAAVDLLVPGVGELCGGSLREERLDLLR----------SRLGEYLDLRRFGSVPHGGFGLGFERYLQCILGVDNIKDVIPFPR 440          

Query:  589 DTRLDYRYFEL--RTITNQAIIHLTDDIKFYFISYLRSQGFRDINCP--SIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRH--YHEVLHTICDTMV-HI---FKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGE----FEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAV--------RPFYTMPDADY----PGFSNSYDFFMRGEEIMSGAQRVHDPVMLRE------SAVKHGIKLDTIKD--YLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFP 1539
            +TR   RY +L       Q  I +   I  Y  S+L   GF +I  P  +II   +     +      + K Y+  +P+LY +M +VGG  +VY + R FR E  +   H  EFT  +  M ++ +    E+   +   MV HI   +K     +  E  A +  F   PF  +  T  L  + GV        +  E    F+DL                  D  V D   +           P    P A +     G +  ++ F+  +EI +    ++DP+  RE       A   G       D  +  + EYG  P AG G+G++R+ M     +NI+ V +FP
Sbjct:  245 ETRFRQRYLDLILNDFVRQKFI-IRAKIITYLRSFLDQMGFLEIETPMMNIIPGGAVARPFITHHNELDMKLYMRVAPELYHKMLVVGGIDRVYEVGRQFRNEGIDL-THNPEFTTCEFYMAYADYTDLMEITEKLLSGMVKHITGGYKVTYHPDGPEGQAYEIDFT-PPFRKVSMTHDLEKAMGVKFPPTDSYDSDETRKFFDDLCVQKGVECPPPRTTARLLDKLVGDFLEVTCINPTFIIDHPQIMSPLAKWHRSKKGLTERFELFVMKKEICNAYTELNDPIRQRELFEQQAKAKAEGDDEAMFIDETFCTALEYGLPPTAGWGMGIDRLTMFLTDSNNIKEVLLFP 592          

Query:  301 MVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            MVIRDDIYSVQC+AWVGEKISK MVNFIGNIPKESLVEVEGTVVLVEKPVESCTQSTVELQIESVKVVSRSKSRLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEKILGKLIKKKFGTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP
Sbjct:    1 MVIRDDIYSVQCVAWVGEKISKPMVNFIGNIPKESLVEVEGTVVLVEKPVESCTQSTVELQIESVKVVSRSKSRLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEKILGKLIKKKFGTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 421          

Query:  370 MVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            MVNFIGNIPKESLVEVEGTVVLVEKPVESCTQSTVELQIESVKVVSRSKSRLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEKILGKLIKKKFGTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP
Sbjct:    1 MVNFIGNIPKESLVEVEGTVVLVEKPVESCTQSTVELQIESVKVVSRSKSRLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGIEMGEFEDLTTTNEKILGKLIKKKFGTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 398          

Query:  202 FVEINLVNESIASKIVTIKGFLHQVRKTGKQ-AFMVIRDDIYSVQCIAWVGEKISKLM----------VNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYLRSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLAQSPQLYKQ--MAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEKNNAAEIAAVKKQFNIEPFEFLEPTLILNFSEGVAMLNEAGI---EMGEFE---DLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRG-EEIMSGAQRVHDPVMLRESAVKHGIKLDTIKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPRDPSRLTP 1563
            +  +N +++S+  + + +KG +  +RK  K+  F+ +RD    +QC+  + +K+ K+           V   G + +               P ++ T   +EL  +  +        L   +E A   ++  N A    D + + R+  +R       I +       F  + ++ GF +   P+I+    EGG+ +F+  YF + AYL+QS QLY +  + ++G C   + I+R +RAE S T RHL+E+  ++ E+ F   + ++L  I D +V + K   +   + +  V    N +P E  +P   + + + +  L+E  I   E G++E   D+    E+ +  +I K       +L +FP+ ++ FY     D P  + S D  + G  EI+ G+ R+ D   L     +  +       Y +   +G SPH G G+G ER +   L  ++IR V ++PR   R  P
Sbjct:   19 YCHLNKLSQSVGQRFL-VKGRVQHLRKQSKKLWFLTLRDGTGYLQCV--LEDKLCKIKEASQLERECSVAIYGTVKEL--------------PADNKTVGGIELIADFWE--------LIGGVERAGGIESVVN-ADSEPDVQFNNRHLMIRGENTSKTILMQSFAFEAFRKFYKNGGFSETAPPTIVQTQCEGGSTLFKFDYFGEDAYLSQSSQLYLETLVPVLGNC---FCITRSYRAEKSRTRRHLSEYNHIEAELDFI-SFDDLLTHIEDMLVSVSKLALEIGGSTLLDVNP--NYKPLE--KPFCRMEYKDAIKFLDEHNICKAEGGKYEFGDDIPEAAERRMTDIINKPI-----MLTRFPVELKAFYMAKCHDDPRVTESVDVLIPGVGEIVGGSMRIWDSKELLAGYARENLDPTPYYWYTDMRAFGSSPHGGYGLGFERFLTWMLDKEHIRDVCLYPRYTGRCEP 453          

Query:  682 SYLRSQGFRDINCPSIISAASEGGANVFE--VKYFNDKAY-----LAQSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYHEVLHTICDTMVHIFKELEK----NNAAEIAAVKKQFNIEPFEFLEPTLI-----------LNFSEGVAMLNEA-----GIEMGEFEDLTTTNEXXXXXXXXXXXXTDFYVLDKFPLAVRPFYTMPDADYPGFSNSYDFFMRGEEIMSGAQRVHDPVMLRESAVKHGIKLDT-IKDYLESFEYGCSPHAGGGIGLERVVMLYLGLDNIRRVSMFPR 1542
            +Y+ +  + +++ P + S   EG    ++  ++  N+        L  S QL+ + A+V G  KVYT+  +FRA  S T  HL+EF  L++E   S + + V+  +C+++ H+ K L +    NNA  +  ++K   ++  EF    L+           ++F + V +L E+     G+ + E E     ++    +L+        +V D FP++ +PFY  P+                 E++ G+ R  D   L+ S +KH    +T +  YL+    G  PH+G G+G +R++  + G+ NI+ V  FPR
Sbjct:  108 NYMITNEYLEVDPPILTSIDCEGAGEAYKAIIETPNESIIIKPQNLTVSAQLHLE-ALVLGYGKVYTLGPIFRANKSRTRHHLSEFLMLEVE---SININSVI-DLCNSIEHLIKTLSRDFFNNNADNLELIRKSNLVQSEEFSGLELLSETISDNNFIRISFQQAVEILKESKIISPGLRIEEIE----FSKSEEQRLVSLLGNRPVFVTD-FPMSQKPFYCRPNEGGETVMAVDLLLPFVGEVVGGSVRDTDYDRLK-SRMKHAKLNETDMNWYLDLRGTGSCPHSGFGVGFDRLLQFWTGVYNIQDVVTFPR 411          

Query:  181 FNSNSISFVEINLVNESIASKIVTIKGFLHQVRKTGKQAFMVIRDDIYSVQCIAWVGEKISKLMVNFIGNIPKXXXXXXXXXXXXXXKPVESCTQSTVELQIEXXXXXXXXXXXLPLQIEDASRPDTDNNLAKVNLDTRLDYRYFELRTITNQAIIHLTDDIKFYFISYL-RSQGFRDINCPSIISAASEGGANVFEVKYFNDKAYLA--QSPQLYKQMAIVGGCKKVYTISRVFRAENSNTHRHLTEFTGLDLEMQFSRHYH 960
            F+S S   +    +N     + V + G+LH  R  G    +++RD    VQ I       + L+   I ++     VE         +  E      VE+ I+ ++V++ +   LP  I+D           K +   RL +RY +LR    Q I+ L   ++F F  +L +   F +I  PS+  + S GGA  F V   +     A  QSPQ +KQ+ +VGG  +   ++R +R E S   R   EFT LDLEM F   +H
Sbjct:   24 FSSYSNRILNCGDINLKTCDQKVVLYGWLHNSRFKGN--ILLLRDSSGIVQLIPN-----NDLICKSIPSLESVIKVEGLVKKRPENQINEKIKTGLVEVLIDKLEVLNEADKNLPFFIKDYH---------KTSEMHRLKHRYIDLRREDIQNILRLRSSLEFSFCEFLIKINNFVNIGTPSLFKS-SPGGAREFVVPTKDPGMCYALIQSPQQHKQLLMVGGVDRYMQLARCYRNEMSRPDRQ-PEFTQLDLEMSFIEKHH 268