Tyrosine-protein kinase

Overview


Name	Tyrosine-protein kinase
Smed ID	SMED30026402
Length (bp)	2044

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Tyrosine-protein kinase (SMED30026402) t-SNE clustered cells

Violin plots show distribution of expression levels for Tyrosine-protein kinase (SMED30026402) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tyrosine-protein kinase (SMED30026402) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tyrosine-protein kinase (SMED30026402) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30026402

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30026402	SMESG000045588.1 SMESG000029204.1	dd_Smed_v4_3147_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30026402	SMESG000045588.1 SMESG000029204.1	dd_Smed_v4_3147_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30026402	SMESG000045588.1 SMESG000029204.1	dd_Smed_v4_3147_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283])

HSP 1 Score: 431.409 bits (1108), Expect = 9.685e-144
Identity = 221/455 (48.57%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530

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Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530

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Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530

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BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283])

HSP 1 Score: 426.402 bits (1095), Expect = 1.032e-141
Identity = 223/461 (48.37%), Postives = 302/461 (65.51%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISS-----DMSEA-WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I +     D+ E  WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 536

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BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: HCK (HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840])

HSP 1 Score: 422.165 bits (1084), Expect = 1.117e-140
Identity = 215/450 (47.78%), Postives = 296/450 (65.78%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC-PQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDD-VYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            V AL+ YEA H +DL F KGD M +  +  E WW A    T+K GYIPSNYV   D   +    +  I+ K+A+++LL  GN +G+++IR    +K  Y+LSVR +D  +    VKHYKIRTLDN  GFYIS RS F  +  L+ +Y+   DGLC KL++ C   + + P +    E+ R+ ++LE+ LG G FGEV++  +N   +VAVK +KP SM    F+AEA +M  L H ++V++  V T+   +P++IITE MA G+LL++L+S EG K  L +++D  +QIAEGMA++E RN++HRDLRAANILV   L  K+ADFGLARV +D  Y A  G KFPIKWTAPEA     F++KSDVWSFG+L+ EIVTYGR PYPG+ N +V+  + +GYR+P P      CP+ELY I ++CW   PE RPTF ++Q + + +    ESQY
Sbjct:   62 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGD-TVKHYKIRTLDNG-GFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK---EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN----CPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQY 501

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56])

HSP 1 Score: 402.905 bits (1034), Expect = 7.118e-134
Identity = 206/467 (44.11%), Postives = 300/467 (64.24%), Query Frame = 2

Query:  281 NQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPC-SDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRH--KPPIQF---KDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLS----VKVADFGLAR--VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELY-AIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             +R T+ AL+ Y++R   DL F KGD MY+    +  WW   H  T +TGY+P N+V       S  E WY   I    A++ +L    P GT++IR   +D++ +AL++R  D  +N   VKHYKI+ LD++ G++I+ R  F ++  L++YY    DGLCC+LT   P+    +P +     ++ E+ R+ + L+R LG+G+FGEV+ GKW   VEVA+K +KP +M    F+ EA++M + +HP +V++  VCT+  E+P +IITE M NG+LL YLR+ +G  L +  ++DM +QIA GM YLE R  VHRDL A N+LV + +S    VKVADFGLAR  + +D+Y A TG KFPIKWTAPEA     F+VKSDVWS+G+L+YEI+T G+ PYPG+ NR+V+++V  GYR+P P G    CP+++Y  + LKCWD  P+ RPTF  L   F+ + ++ +  Y
Sbjct:   15 QERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTR--EEPFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNY 472

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56])

HSP 1 Score: 403.29 bits (1035), Expect = 2.429e-133
Identity = 206/467 (44.11%), Postives = 300/467 (64.24%), Query Frame = 2

Query:  281 NQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPC-SDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRH--KPPIQF---KDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLS----VKVADFGLAR--VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELY-AIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             +R T+ AL+ Y++R   DL F KGD MY+    +  WW   H  T +TGY+P N+V       S  E WY   I    A++ +L    P GT++IR   +D++ +AL++R  D  +N   VKHYKI+ LD++ G++I+ R  F ++  L++YY    DGLCC+LT   P+    +P +     ++ E+ R+ + L+R LG+G+FGEV+ GKW   VEVA+K +KP +M    F+ EA++M + +HP +V++  VCT+  E+P +IITE M NG+LL YLR+ +G  L +  ++DM +QIA GM YLE R  VHRDL A N+LV + +S    VKVADFGLAR  + +D+Y A TG KFPIKWTAPEA     F+VKSDVWS+G+L+YEI+T G+ PYPG+ NR+V+++V  GYR+P P G    CP+++Y  + LKCWD  P+ RPTF  L   F+ + ++ +  Y
Sbjct:   71 QERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTR--EEPFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNY 528

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Query:  281 NQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPC-SDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRH--KPPIQF---KDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLS----VKVADFGLAR--VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELY-AIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             +R T+ AL+ Y++R   DL F KGD MY+    +  WW   H  T +TGY+P N+V       S  E WY   I    A++ +L    P GT++IR   +D++ +AL++R  D  +N   VKHYKI+ LD++ G++I+ R  F ++  L++YY    DGLCC+LT   P+    +P +     ++ E+ R+ + L+R LG+G+FGEV+ GKW   VEVA+K +KP +M    F+ EA++M + +HP +V++  VCT+  E+P +IITE M NG+LL YLR+ +G  L +  ++DM +QIA GM YLE R  VHRDL A N+LV + +S    VKVADFGLAR  + +D+Y A TG KFPIKWTAPEA     F+VKSDVWS+G+L+YEI+T G+ PYPG+ NR+V+++V  GYR+P P G    CP+++Y  + LKCWD  P+ RPTF  L   F+ + ++ +  Y
Sbjct:   71 QERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTR--EEPFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNY 528

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56])

HSP 1 Score: 403.29 bits (1035), Expect = 2.666e-133
Identity = 206/467 (44.11%), Postives = 300/467 (64.24%), Query Frame = 2

Query:  281 NQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPC-SDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRH--KPPIQF---KDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLS----VKVADFGLAR--VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELY-AIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             +R T+ AL+ Y++R   DL F KGD MY+    +  WW   H  T +TGY+P N+V       S  E WY   I    A++ +L    P GT++IR   +D++ +AL++R  D  +N   VKHYKI+ LD++ G++I+ R  F ++  L++YY    DGLCC+LT   P+    +P +     ++ E+ R+ + L+R LG+G+FGEV+ GKW   VEVA+K +KP +M    F+ EA++M + +HP +V++  VCT+  E+P +IITE M NG+LL YLR+ +G  L +  ++DM +QIA GM YLE R  VHRDL A N+LV + +S    VKVADFGLAR  + +D+Y A TG KFPIKWTAPEA     F+VKSDVWS+G+L+YEI+T G+ PYPG+ NR+V+++V  GYR+P P G    CP+++Y  + LKCWD  P+ RPTF  L   F+ + ++ +  Y
Sbjct:   75 QERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTR--EEPFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNY 532

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BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56])

HSP 1 Score: 403.29 bits (1035), Expect = 2.666e-133
Identity = 206/467 (44.11%), Postives = 300/467 (64.24%), Query Frame = 2

Query:  281 NQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPC-SDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRH--KPPIQF---KDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLS----VKVADFGLAR--VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELY-AIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             +R T+ AL+ Y++R   DL F KGD MY+    +  WW   H  T +TGY+P N+V       S  E WY   I    A++ +L    P GT++IR   +D++ +AL++R  D  +N   VKHYKI+ LD++ G++I+ R  F ++  L++YY    DGLCC+LT   P+    +P +     ++ E+ R+ + L+R LG+G+FGEV+ GKW   VEVA+K +KP +M    F+ EA++M + +HP +V++  VCT+  E+P +IITE M NG+LL YLR+ +G  L +  ++DM +QIA GM YLE R  VHRDL A N+LV + +S    VKVADFGLAR  + +D+Y A TG KFPIKWTAPEA     F+VKSDVWS+G+L+YEI+T G+ PYPG+ NR+V+++V  GYR+P P G    CP+++Y  + LKCWD  P+ RPTF  L   F+ + ++ +  Y
Sbjct:   75 QERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTR--EEPFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNY 532

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src42A (gene:FBgn0264959 transcript:FBtr0335275)

HSP 1 Score: 391.734 bits (1005), Expect = 7.230e-129
Identity = 211/458 (46.07%), Postives = 287/458 (62.66%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH--YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQF------KDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRS--PEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ Y+AR  +DL F KG+ + I +D    WWLA    T+  GYIPSNYV          E WY   I   EA+KKLL   N  G ++IR  S+S+H  Y+LSVR  DT      VKHY+IR LD   GF+I+ R+ F  +  L+++Y  ++DGLC  L   C Q  KP  +          E+ R  ++  R LG+G FG+V+ G WNN+  VA+K LK  +MD   F+AEA++M KL H +++Q+  VCT   E+P++IITELM +G+LL YL++   +G+ L++  ++DM +QIA GMAYLES+N++HRDL A N+LV +   VK+ADFGLAR + +D Y A  G +FPIKWTAPEA    +FS+KSDVWSFG+L+ E+VTYGR PYPG+ N +VL +V  GYR+P P      C   LY I L+CW   P  RPTF  LQ   E +  + +S Y
Sbjct:   70 ALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNYVA--KLKSIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRD-SESRHNDYSLSVRDGDT------VKHYRIRQLDEG-GFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTV--EEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPN----CEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDY 511

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100508)

HSP 1 Score: 387.882 bits (995), Expect = 6.108e-127
Identity = 193/458 (42.14%), Postives = 289/458 (63.10%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDI--------EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARV-TDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             V AL+ Y++R   DL F KGD M +  D    WW  ++ TT++ G IP N+V  +    S    + ++  KEADK LL   NP GT+++RP   + + Y+LSV+ ++  + Y+V KHY+I+ LDN  G+YI+    FP++ +L+  Y  N  GLC  L+  CP   KP  Q  D+        E+ R  I+L R LG G+FGEV+ GKW NS++VAVK L+  +M  + F+ EA +M K  H R+V +  VC+Q  E+P++I+ E M+ G+LL++LR  +G+ L   +++ + +Q+A GM YLES+  +HRDL A N+L+ E+   K+ DFGLARV  DD Y    G++FP+KWTAPEA +  +FS+KSDVWS+G+L+ E+ TYG+ PYPG+ +R+V++ + +G+R+P P       PD +Y + L+CWDA PE RPTF  L   FE + + +E  Y
Sbjct:   99 VVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNG-GYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ--EEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100505)

HSP 1 Score: 387.882 bits (995), Expect = 6.108e-127
Identity = 193/458 (42.14%), Postives = 289/458 (63.10%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDI--------EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARV-TDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             V AL+ Y++R   DL F KGD M +  D    WW  ++ TT++ G IP N+V  +    S    + ++  KEADK LL   NP GT+++RP   + + Y+LSV+ ++  + Y+V KHY+I+ LDN  G+YI+    FP++ +L+  Y  N  GLC  L+  CP   KP  Q  D+        E+ R  I+L R LG G+FGEV+ GKW NS++VAVK L+  +M  + F+ EA +M K  H R+V +  VC+Q  E+P++I+ E M+ G+LL++LR  +G+ L   +++ + +Q+A GM YLES+  +HRDL A N+L+ E+   K+ DFGLARV  DD Y    G++FP+KWTAPEA +  +FS+KSDVWS+G+L+ E+ TYG+ PYPG+ +R+V++ + +G+R+P P       PD +Y + L+CWDA PE RPTF  L   FE + + +E  Y
Sbjct:   99 VVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNG-GYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ--EEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100504)

HSP 1 Score: 387.882 bits (995), Expect = 6.108e-127
Identity = 193/458 (42.14%), Postives = 289/458 (63.10%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDI--------EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARV-TDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             V AL+ Y++R   DL F KGD M +  D    WW  ++ TT++ G IP N+V  +    S    + ++  KEADK LL   NP GT+++RP   + + Y+LSV+ ++  + Y+V KHY+I+ LDN  G+YI+    FP++ +L+  Y  N  GLC  L+  CP   KP  Q  D+        E+ R  I+L R LG G+FGEV+ GKW NS++VAVK L+  +M  + F+ EA +M K  H R+V +  VC+Q  E+P++I+ E M+ G+LL++LR  +G+ L   +++ + +Q+A GM YLES+  +HRDL A N+L+ E+   K+ DFGLARV  DD Y    G++FP+KWTAPEA +  +FS+KSDVWS+G+L+ E+ TYG+ PYPG+ +R+V++ + +G+R+P P       PD +Y + L+CWDA PE RPTF  L   FE + + +E  Y
Sbjct:   99 VVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNG-GYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ--EEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547

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BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0304990)

HSP 1 Score: 387.882 bits (995), Expect = 6.108e-127
Identity = 193/458 (42.14%), Postives = 289/458 (63.10%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDI--------EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARV-TDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
             V AL+ Y++R   DL F KGD M +  D    WW  ++ TT++ G IP N+V  +    S    + ++  KEADK LL   NP GT+++RP   + + Y+LSV+ ++  + Y+V KHY+I+ LDN  G+YI+    FP++ +L+  Y  N  GLC  L+  CP   KP  Q  D+        E+ R  I+L R LG G+FGEV+ GKW NS++VAVK L+  +M  + F+ EA +M K  H R+V +  VC+Q  E+P++I+ E M+ G+LL++LR  +G+ L   +++ + +Q+A GM YLES+  +HRDL A N+L+ E+   K+ DFGLARV  DD Y    G++FP+KWTAPEA +  +FS+KSDVWS+G+L+ E+ TYG+ PYPG+ +R+V++ + +G+R+P P       PD +Y + L+CWDA PE RPTF  L   FE + + +E  Y
Sbjct:   99 VVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNG-GYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ--EEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547

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BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: lyn (LYN proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-040912-7])

HSP 1 Score: 432.18 bits (1110), Expect = 1.062e-144
Identity = 226/459 (49.24%), Postives = 304/459 (66.23%), Query Frame = 2

Query:  275 MYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC--PQRHKPPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVT-DDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            M  +   V AL+ YEA H DDL F KG+ + I  +  E WW A   TT+K G+IPSNYV   D   +    + DIT K+A+++LL   N  G+Y+IR    SK  Y+LS+R  D  +   VVKHYKIR+LDN  G+YIS +  F +ISS+IK+Y   +DGLC KL  +C  P+  KP    KD  E+S+D I++ + LG G FGEV++  +NNS +VAVK LKP +M    F+ EA LM  L H R+V++  V T+   +P++IITE MANG+LL++L+S  G K++L +++D  +QIAEGMAY+E +N++HRDLRAAN+LV E L  K+ADFGLARV  DD Y A  G KFPIKWTAPEA     F++KSD+WSFGVL+YEI+TYG+ PYPG+ N +V+  V +GYR+P P      CP ELY I   CW   PE+RPTF ++Q + + +    E QY
Sbjct:   59 MEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGE-WWKARSLTTRKEGFIPSNYVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDA-QGQDVVKHYKIRSLDNG-GYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKP--WDKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKTLKPGTMSVEAFLEEANLMKTLQHDRLVRLYAVVTK--TEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPEN----CPVELYEIMTTCWKNKPEDRPTFDYIQSVLDDFYTATEGQY 506

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BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: src (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [Source:NCBI gene;Acc:325084])

HSP 1 Score: 428.328 bits (1100), Expect = 8.394e-143
Identity = 220/455 (48.35%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   TT ++GYIPSNYV   D   +  E WY   IT +++++ LL + N  GT+++R    +K  Y LSV  +D  K   V KHYKIR LD+  GFYI++R++F  +  L+ +Y+ + DGLC  LT  CP   KPP Q   +D  E+ RD +RL+  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM SQIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CPD L+ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   86 TFVALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQA--EEWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSVLDYDNVKGLNV-KHYKIRKLDSG-GFYITSRTQFSTLQQLVNHYRQHADGLCHSLTDVCPVL-KPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMGQGSLLDFLKGDMGKMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPDSLHELMLTCWRKEPEERPTFEYLQGFLEDYFTSTEPQY 528

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Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   TT ++GYIPSNYV   D   +  E WY   IT +++++ LL + N  GT+++R    +K  Y LSV  +D  K   V KHYKIR LD+  GFYI++R++F  +  L+ +Y+ + DGLC  LT  CP   KPP Q   +D  E+ RD +RL+  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM SQIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CPD L+ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   86 TFVALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQA--EEWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSVLDYDNVKGLNV-KHYKIRKLDSG-GFYITSRTQFSTLQQLVNHYRQHADGLCHSLTDVCPVL-KPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMGQGSLLDFLKGDMGKMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPDSLHELMLTCWRKEPEERPTFEYLQGFLEDYFTSTEPQY 528

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BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: fyna (FYN proto-oncogene, Src family tyrosine kinase a [Source:NCBI gene;Acc:373872])

HSP 1 Score: 424.476 bits (1090), Expect = 3.077e-141
Identity = 213/454 (46.92%), Postives = 300/454 (66.08%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC----PQRHKPPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ YEAR  DDL F KG+   I +     WW A   TT  TGYIPSNYV   D   +  E WY   +  K+A+++LL  GNP GT++IR    +K  Y+LS++ +D TK  +V KHYKIR LDN  G+YI+ R++F  +  L+ +Y     GLCC+L + C    P+     ++ KD+ E+ R+ ++L + LGNG FGEV++G WN + +VAVK LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+  EG+ L+L  ++DM +Q+A GMAY+E  N++HRDLR+ANILV + L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+VT GR PYPG+ NR+VL++V +GYR+P P      CP  L+ + L+CW   PE RPTF +LQ   E +    E QY
Sbjct:   89 ALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQA--EDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDETKGDHV-KHYKIRKLDNG-GYYITTRAQFETLQQLVHHYSARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQD----CPSSLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQY 531

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BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: src (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [Source:NCBI gene;Acc:325084])

HSP 1 Score: 421.779 bits (1083), Expect = 3.188e-140
Identity = 220/461 (47.72%), Postives = 301/461 (65.29%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEA------WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++  +       WWLA   TT ++GYIPSNYV   D   +  E WY   IT +++++ LL + N  GT+++R    +K  Y LSV  +D  K   V KHYKIR LD+  GFYI++R++F  +  L+ +Y+ + DGLC  LT  CP   KPP Q   +D  E+ RD +RL+  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM SQIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CPD L+ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   86 TFVALYDYESRTASDLSFRKGERLQIVNNTRKLNPREGDWWLARSLTTGESGYIPSNYVAPSDSIQA--EEWYFGKITRRDSERLLLNLENRRGTFLVRESETTKGAYCLSVLDYDNVKGLNV-KHYKIRKLDSG-GFYITSRTQFSTLQQLVNHYRQHADGLCHSLTDVCPVL-KPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMGQGSLLDFLKGDMGKMLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPDSLHELMLTCWRKEPEERPTFEYLQGFLEDYFTSTEPQY 534

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161])

HSP 1 Score: 429.483 bits (1103), Expect = 7.991e-144
Identity = 220/455 (48.35%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   ++ +TGYIPSNYV   D   +  E WY   IT +EA++ LL + NP GT+++R    +K  Y LSV  +D  +   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ RD +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +    E QY
Sbjct:   34 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQA--EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPT-AKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD----CPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQY 476

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161])

HSP 1 Score: 429.483 bits (1103), Expect = 9.032e-144
Identity = 220/455 (48.35%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   ++ +TGYIPSNYV   D   +  E WY   IT +EA++ LL + NP GT+++R    +K  Y LSV  +D  +   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ RD +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +    E QY
Sbjct:   41 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQA--EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPT-AKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD----CPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQY 483

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161])

HSP 1 Score: 429.098 bits (1102), Expect = 1.015e-143
Identity = 220/455 (48.35%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   ++ +TGYIPSNYV   D   +  E WY   IT +EA++ LL + NP GT+++R    +K  Y LSV  +D  +   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ RD +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +    E QY
Sbjct:   36 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQA--EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPT-AKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD----CPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQY 478

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161])

HSP 1 Score: 429.098 bits (1102), Expect = 2.274e-143
Identity = 220/455 (48.35%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   ++ +TGYIPSNYV   D   +  E WY   IT +EA++ LL + NP GT+++R    +K  Y LSV  +D  +   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ RD +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +    E QY
Sbjct:   58 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQA--EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPT-AKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD----CPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQY 500

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BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161])

HSP 1 Score: 430.254 bits (1105), Expect = 2.296e-143
Identity = 220/455 (48.35%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   ++ +TGYIPSNYV   D   +  E WY   IT +EA++ LL + NP GT+++R    +K  Y LSV  +D  +   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ RD +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +    E QY
Sbjct:   84 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQA--EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPT-AKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD----CPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQY 526

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BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Src (Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:98397])

HSP 1 Score: 429.869 bits (1104), Expect = 2.301e-143
Identity = 221/455 (48.57%), Postives = 299/455 (65.71%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   87 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 529

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Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   87 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 529

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Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   87 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 529

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BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Src (Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:98397])

HSP 1 Score: 424.861 bits (1091), Expect = 2.347e-141
Identity = 223/461 (48.37%), Postives = 301/461 (65.29%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISS-----DMSEA-WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I +     D+ E  WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   87 TFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 535

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Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISS-----DMSEA-WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I +     D+ E  WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   87 TFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 535

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BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P42687|SPK1_GIRTI (Tyrosine-protein kinase SPK-1 OS=Girardia tigrina OX=6162 PE=2 SV=1)

HSP 1 Score: 429.869 bits (1104), Expect = 4.597e-143
Identity = 209/440 (47.50%), Postives = 290/440 (65.91%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGF-YISNRSKFPNISSLIKYYQTNTDG-LCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTD-DVYNADTGT-KFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAG--GKIVCPDELYAIKLKCWDAYPENRPTFSHLQD 1597
            V+A + Y A    D+ F + ++MY+     E W   +     K G +PSNYV   DGSP S E W +I   EA+K L+++G   GTYIIRP      YALSVR FD  K   +VKH++I+TL +  G  Y  N   FPNI +LI++Y+ N  G     LT   P  ++PP+ F+DIE++R+ I +   +G G FG V+  KW  S EVA K L+ +  +R +F+ EA++MHKL H +IV++LGVCT+P + P+ II E M NG+L  YL++P+G+K  LN+M+ MM++I+EGMAYLES   VHRDLRA NILV  DL+ KVADFGL  +TD  + + +  T +FP KWTAPEA   + F+ KSDVWS+G++M+EI+T+  +PYP IP ++V+++VSKGYR+PNP      + CPDE+Y I + CWDA PE RPTF  LQ+
Sbjct:   38 VKAKYKYAASGDTDISFEEKEIMYVLEQFDEFWLKVVKQKDNKEGLVPSNYVSKQDGSPQSVEAWREIQRWEAEKSLMKIGLQKGTYIIRPSRKENSYALSVRDFDEKKKICIVKHFQIKTLQDEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDPMPDNYQPPVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILTWASSPYPDIPAKEVIEKVSKGYRMPNPEKFITGVCCPDEIYKIMIWCWDANPEKRPTFLVLQE 477

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BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P12931|SRC_HUMAN (Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3)

HSP 1 Score: 431.409 bits (1108), Expect = 4.651e-143
Identity = 221/455 (48.57%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530

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BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P13116|SRC2_XENLA (Tyrosine-protein kinase Src-2 OS=Xenopus laevis OX=8355 GN=src-b PE=2 SV=3)

HSP 1 Score: 431.024 bits (1107), Expect = 4.914e-143
Identity = 220/455 (48.35%), Postives = 301/455 (66.15%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   ++ +TGYIPSNYV   D   +  E WY   IT +EA++ LL + NP GT+++R    +K  Y LSV  +D ++   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ RD +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +    E QY
Sbjct:   84 TFVALYDYESRTETDLSFRKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQA--EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDASRGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTAVCPT-AKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD----CPESLHDLMFQCWRKDPEERPTFEYLQAFLEDYFTATEPQY 526

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BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P00523|SRC_CHICK (Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus OX=9031 GN=SRC PE=1 SV=4)

HSP 1 Score: 430.254 bits (1105), Expect = 1.092e-142
Identity = 222/455 (48.79%), Postives = 300/455 (65.93%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   TT +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   85 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQY 527

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BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q9WUD9|SRC_RAT (Proto-oncogene tyrosine-protein kinase Src OS=Rattus norvegicus OX=10116 GN=Src PE=1 SV=4)

HSP 1 Score: 429.869 bits (1104), Expect = 1.792e-142
Identity = 221/455 (48.57%), Postives = 299/455 (65.71%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   +T +TGYIPSNYV   D   +  E WY   IT +E+++ LL   NP GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F ++  L+ YY  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV E+L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P P      CP+ L+ +  +CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA--EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: G7YFZ5 (Tyrosine-protein kinase OS=Clonorchis sinensis OX=79923 GN=CLF_106945 PE=3 SV=1)

HSP 1 Score: 619.002 bits (1595), Expect = 0.000e+0
Identity = 284/448 (63.39%), Postives = 355/448 (79.24%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYF 1639
            VRAL++Y  +H DDL F KGD M++S D+S  WWLA H  T  TGYIPSNYV++DDG P+S + WYDI+ +EADK+LLR+GNP GTY+IR  S++++YALSVRH+D  +N YVVKHY+IR LDN+ G++ISNR  FPNI  LI YY    +GLCC+LT+ CP+ ++PP+QF+D EV+R+ I + R LG+GSFGEVYL KWN+SVEVAVK ++ +  DR++FI EA LMH+ +HPRIVQ+LGVCTQP ++PV+IITELMA GAL+++LR  EGQ+L L++++DMM+QIA GM YLE RN VHRDLRAANILVD D SVKV+DFGLA++  D   AD  TKFPIKWTAPEA +Q  FS+KSDVWSFGVLMYEIVTYG TPYPG+  RQ + EV KGYRLPNP      CPD+LY I LKCWD  PENRPTF  L D+F++W  + E+QYF
Sbjct:  109 VRALYTYTGQHQDDLPFRKGDTMFVS-DVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSETQNYALSVRHYDQERNIYVVKHYRIRVLDNDNGYFISNRITFPNIKDLISYYSRTAEGLCCRLTVPCPRDYRPPVQFRDFEVNRNSITMVRQLGHGSFGEVYLAKWNDSVEVAVK-MRLSHTDRTKFIEEARLMHEFHHPRIVQLLGVCTQPEDEPVYIITELMAKGALVDFLRGDEGQQLSLSDLIDMMAQIASGMTYLEERNSVHRDLRAANILVDSDNSVKVSDFGLAKIISDDAQADHSTKFPIKWTAPEAALQHIFSIKSDVWSFGVLMYEIVTYGGTPYPGMSTRQTIVEVDKGYRLPNPHTANHPCPDDLYNIMLKCWDVRPENRPTFRSLYDVFDNWASHVETQYF 554

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A4S2LUM5 (Tyrosine-protein kinase OS=Opisthorchis felineus OX=147828 GN=CRM22_004736 PE=3 SV=1)

HSP 1 Score: 618.616 bits (1594), Expect = 0.000e+0
Identity = 284/448 (63.39%), Postives = 355/448 (79.24%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYF 1639
            VRAL++Y  +H DDL F KGD M++S D+S  WWLA H  T  TGYIPSNYV++DDG P+S + WYDI+ +EADK+LLR+GNP GTY+IR  S++++YALSVRH+D  +N YVVKHY+IR LDN+ G++ISNR  FPNI  LI YY    +GLCC+LT+ CP+ ++PP+QF+D EV+R+ I + R LG+GSFGEVYL KWN+SVEVAVK ++ +  DR++FI EA LMH+ +HPRIVQ+LGVCTQP ++PV+IITELMA GAL+++LR  EGQ+L L++++DMM+QIA GM YLE RN VHRDLRAANILVD D SVKV+DFGLA++  D   AD  TKFPIKWTAPEA +Q  FS+KSDVWSFGVLMYEIVTYG TPYPG+  RQ + EV KGYRLPNP      CPD+LY I LKCWD  PENRPTF  L D+F++W  + E+QYF
Sbjct:  109 VRALYTYTGQHQDDLPFRKGDTMFVS-DVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSETQNYALSVRHYDQERNIYVVKHYRIRVLDNDNGYFISNRITFPNIKDLISYYSRTAEGLCCRLTVPCPRDYRPPVQFRDFEVNRNSITMVRQLGHGSFGEVYLAKWNDSVEVAVK-MRLSHTDRTKFIEEARLMHEFHHPRIVQLLGVCTQPEDEPVYIITELMAKGALVDFLRGDEGQQLSLSDLIDMMAQIASGMTYLEERNSVHRDLRAANILVDSDNSVKVSDFGLAKIISDDAQADHSTKFPIKWTAPEAALQHIFSIKSDVWSFGVLMYEIVTYGGTPYPGMSTRQTIVEVDKGYRLPNPHTANHPCPDDLYNIMLKCWDVRPENRPTFRSLYDVFDNWASHVETQYF 554

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A074ZSJ9 (Tyrosine-protein kinase OS=Opisthorchis viverrini OX=6198 GN=T265_04412 PE=3 SV=1)

HSP 1 Score: 618.616 bits (1594), Expect = 0.000e+0
Identity = 284/448 (63.39%), Postives = 355/448 (79.24%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYF 1639
            VRAL++Y  +H DDL F KGD M++S D+S  WWLA H  T  TGYIPSNYV++DDG P+S + WYDI+ +EADK+LLR+GNP GTY+IR  S++++YALSVRH+D  +N YVVKHY+IR LDN+ G++ISNR  FPNI  LI YY    +GLCC+LT+ CP+ ++PP+QF+D EV+R+ I + R LG+GSFGEVYL KWN+SVEVAVK ++ +  DR++FI EA LMH+ +HPRIVQ+LGVCTQP ++PV+IITELMA GAL+++LR  EGQ+L L++++DMM+QIA GM YLE RN VHRDLRAANILVD D SVKV+DFGLA++  D   AD  TKFPIKWTAPEA +Q  FS+KSDVWSFGVLMYEIVTYG TPYPG+  RQ + EV KGYRLPNP      CPD+LY I LKCWD  PENRPTF  L D+F++W  + E+QYF
Sbjct:  109 VRALYTYTGQHQDDLPFRKGDTMFVS-DVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSETQNYALSVRHYDQERNIYVVKHYRIRVLDNDNGYFISNRITFPNIKDLISYYSRTAEGLCCRLTVPCPRDYRPPVQFRDFEVNRNSITMVRQLGHGSFGEVYLAKWNDSVEVAVK-MRLSHTDRTKFIEEARLMHEFHHPRIVQLLGVCTQPEDEPVYIITELMAKGALVDFLRGDEGQQLSLSDLIDMMAQIASGMTYLEERNSVHRDLRAANILVDSDNSVKVSDFGLAKIISDDAQADHSTKFPIKWTAPEAALQHIFSIKSDVWSFGVLMYEIVTYGGTPYPGMSTRQTIVEVDKGYRLPNPHTANHPCPDDLYNIMLKCWDVRPENRPTFRSLYDVFDNWASHVETQYF 554

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: C1LGZ6 (Tyrosine-protein kinase OS=Schistosoma japonicum OX=6182 GN=fyn-prov PE=2 SV=1)

HSP 1 Score: 613.224 bits (1580), Expect = 0.000e+0
Identity = 280/448 (62.50%), Postives = 352/448 (78.57%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYF 1639
            VRAL+SY+  + DDL F KGD+M++ S MS+AWW A HA T  +GYIPSNYV LDDG P+S + WYDI  +EAD+KLL +GNP GTY+IRP S++++YALSVRH+D+ KN +VVKHY+IR LDNN GF+IS R+ FPNI  L+ YY  + DGLCC+L++ CP+ ++PP+QF+D E++RD I   R LG G+FGEVYL KWN SVEVAVK ++ +  DRSRFI EA LMH  +HPRIVQ+LGVCT+P +QPV+IITELM  GAL ++LR+ EG KL L++++D+M+QIA GM+YLE  N VHRDLRAANILVD+D SVKV+DFGLA++  D  +AD  TKFPIKWTAPEA +Q  FS+KSDVWSFG+LMYEIVTYG TPYPG+  RQ + EV KGYRLP P   +  CPD+LY +  KCWDA PENRPTF  L D+FE+W  + E+QY 
Sbjct:  117 VRALYSYQGHNQDDLPFQKGDIMFVVSGMSDAWWFARHAETGMSGYIPSNYVCLDDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVK-MRLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKIISDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHTPEHPCPDDLYNLMRKCWDARPENRPTFRSLYDVFENWSTHTEAQYL 563

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BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A094ZT02 (Tyrosine-protein kinase OS=Schistosoma haematobium OX=6185 GN=MS3_05644 PE=3 SV=1)

HSP 1 Score: 610.912 bits (1574), Expect = 0.000e+0
Identity = 279/448 (62.28%), Postives = 352/448 (78.57%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYF 1639
            VRAL+SY+  + DDL F KGD+M++ S MS+AWW A H+ T  +GYIPSNYV L+DG P+S + WYDI  +EAD+KLL +GNP GTY+IRP S++++YALSVRH+D+ KN +VVKHY+IR LDNN GF+IS R+ FPNI  LI YY  + DGLCC+L++ CP+ ++PP+QF+D E++RD I   R LG G+FGEVYL KWN SVEVAVK ++ +  DRSRFI EA LMH  +HPRIVQ+LGVCT+P +QPV+IITELM  GAL ++LR+ EG KL L++++D+M+QIA GM+YLE  N VHRDLRAANILVD+D SVKV+DFGLA++  D  +AD  TKFPIKWTAPEA +Q  FS+KSDVWSFG+LMYEIVTYG TPYPG+  RQ + EV KGYRLP P   +  CPD+LY +  KCWDA PENRPTF  L D+FE+W  + E+QY 
Sbjct:  117 VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLINYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVK-MRLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKIISDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHTPEHPCPDDLYNLMRKCWDARPENRPTFRSLYDVFENWSTHTEAQYL 563

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BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: fyna (tyrosine-protein kinase fyna [Source:NCBI gene;Acc:103043249])

HSP 1 Score: 422.55 bits (1085), Expect = 1.579e-140
Identity = 212/454 (46.70%), Postives = 299/454 (65.86%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC----PQRHKPPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ YEAR  DDL F KG+   I +     WW A   TT  TGYIPSNYV   D   +  E WY   +  K+A+++LL  GNP GT++IR    +K  Y+LS++ +D  K  +V KHYKIR LDN  G+YI+ R++F  +  L+++Y     GLCC+L + C    P+     ++ KD+ E+ R+ ++L + LGNG FGEV++G WN + +VAVK LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+  EG+ L+L  ++DM +Q+A GMAY+E  N++HRDLR+ANILV + L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+VT GR PYPG+ NR+VL++V +GYR+P P      CP  L+ + L+CW   PE RPTF +LQ   E +    E QY
Sbjct:   89 ALYDYEARTEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQA--EDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDDIKGDHV-KHYKIRKLDNG-GYYITTRAQFETLQQLVQHYSARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVS---EEPIYIVTEYMGKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQY 531

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BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: src (proto-oncogene tyrosine-protein kinase Src [Source:NCBI gene;Acc:103038924])

HSP 1 Score: 421.394 bits (1082), Expect = 4.821e-140
Identity = 220/462 (47.62%), Postives = 300/462 (64.94%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSS-------HEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++    WWLA   TT ++GYIPSNYV   D   +         + WY   IT +++++ LL + N  GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F N+  L+ +Y+ + DGLC  LT  CP   KP  Q   +D  E+ R+ +RL+  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM SQIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFGVL+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CPD L+ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTASDLSFRKGERLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQAEDHLRLTLEKRWYFGKITRRDSERLLLSLDNRRGTFLVRESETTKGAYCLSVLDFDNVKGLNV-KHYKIRKLDSG-GFYITSRTQFSNLQQLVSHYRKHADGLCHFLTDVCPVL-KPQTQGLARDAWEIPRESLRLDLKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMGQGSLLDFLKGDMGKILRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPDSLHDLMLTCWRKEPEERPTFEYLQGFLEDYFTSTEPQY 539

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: src (proto-oncogene tyrosine-protein kinase Src [Source:NCBI gene;Acc:103038924])

HSP 1 Score: 419.468 bits (1077), Expect = 2.568e-139
Identity = 221/461 (47.94%), Postives = 301/461 (65.29%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEA------WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KG+ + I ++  +       WWLA   TT ++GYIPSNYV   D   +  E WY   IT +++++ LL + N  GT+++R    +K  Y LSV  FD  K   V KHYKIR LD+  GFYI++R++F N+  L+ +Y+ + DGLC  LT  CP   KP  Q   +D  E+ R+ +RL+  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M  G+LL++L+   G+ LRL +++DM SQIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFGVL+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CPD L+ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   88 TFVALYDYESRTASDLSFRKGERLQIVNNTRKLNCREGDWWLARSLTTGESGYIPSNYVAPSDSIQA--EEWYFGKITRRDSERLLLSLDNRRGTFLVRESETTKGAYCLSVLDFDNVKGLNV-KHYKIRKLDSG-GFYITSRTQFSNLQQLVSHYRKHADGLCHFLTDVCPVL-KPQTQGLARDAWEIPRESLRLDLKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMGQGSLLDFLKGDMGKILRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPDSLHDLMLTCWRKEPEERPTFEYLQGFLEDYFTSTEPQY 536

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: clul1 (tyrosine-protein kinase yes [Source:NCBI gene;Acc:103029125])

HSP 1 Score: 418.313 bits (1074), Expect = 7.516e-139
Identity = 214/452 (47.35%), Postives = 298/452 (65.93%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ YEAR +DDL F KGD   I ++    WW A    T K GYIPSNYV   D   +  E WY   +  K+A++ LL  GN  GT+++R    +K  Y+LS+R +D  K   V KHYKIR LDN  G+YI+ R++F  +  L+K+Y  + DGLC +LT  CP   KP  Q   KD  E+ R+ +RLE  LG G FGEV++G WN + +VA+K LKP +M    F+ EA++M KL H ++V +  V +   E+P++I+TE M  G+LL++L+  EG+ L+L +++DM +QIA+GMA++E  N++HRDLRAANILV ++L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+VT GR PYPG+ NR+VL++V +GYR+P P G    CP+ L+ +   CW   P+ RPTF ++Q   E +    E QY
Sbjct:  102 ALYDYEARTSDDLSFKKGDRFQIINNTEGDWWEARSINTGKKGYIPSNYVAPADSIQA--EEWYFGKMGRKDAERLLLVPGNQRGTFLVRESETTKGAYSLSIRDWDDMKGDNV-KHYKIRKLDNG-GYYITTRAQFETLQKLVKHYTEHADGLCYRLTTVCPTV-KPQTQGLAKDAWEIPRESLRLELKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLYAVVS---EEPIYIVTEYMGKGSLLDFLKEGEGKYLKLPQLVDMAAQIADGMAFIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG----CPESLHEMMRLCWKKEPDERPTFEYIQSFLEDYFTATEPQY 541

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BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: SRC (proto-oncogene tyrosine-protein kinase Src-like [Source:NCBI gene;Acc:103042998])

HSP 1 Score: 417.927 bits (1073), Expect = 1.098e-138
Identity = 216/462 (46.75%), Postives = 304/462 (65.80%), Query Frame = 2

Query:  272 VMYNQR--PTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            +M  QR   T  AL+ YE+R T DL F KG+ + I ++    WWLA   TT ++GYIPSNYV   D   +    +  IT +++++ LL + N  GT+++R    +K  Y LSV  +D  K   + KHYKIR LD+  GFYI++R++F ++  L+ +Y+T+ DGLC  LT  CP   KP  Q   +D  E+ R+ +RL+  LG G FGEV++G WN +  VA+K LK  +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+  +G+ LRL +++DM SQIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CP  ++ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   79 IMSPQRGVTTFVALYDYESRTTADLTFKKGERLQILNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQAEEWFFGKITRRDSERLLLNIQNRRGTFLVRESETTKGAYCLSVLDYDNMKGLNI-KHYKIRKLDSG-GFYITSRTQFTSLQQLVLHYRTHADGLCHVLTDICPML-KPQTQGLARDAWEIPRESLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKRGTMSPEAFLEEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSQGSLLDFLKGDKGKFLRLPQLVDMASQIAAGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELATKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPSSMHELMLSCWRKEPEERPTFEYLQGFLEDYFTSTEPQY 530

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72])

HSP 1 Score: 422.165 bits (1084), Expect = 1.828e-142
Identity = 213/450 (47.33%), Postives = 296/450 (65.78%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDD-VYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            V AL+ +E  + DD+ F KGD M I  +  E WW+A        GYIPSNYV   +   +    +  ++ KE ++ LL  GN IG Y++R    +K  Y+LSVR +D T N  VV+HYKIRTLDN  G++IS R  FP++ +LI++Y  ++DGLC KL   C  +    +  KD  E+ RD ++L + LG G FGEV++G +NN  +VA+K +KP SM    F+ EA LM  L HPR+V++  V TQ   +P++I+TE M NG+LL+YL+S EG  L + +M+DM +QIAEGMA++E +N++HRDLRAANILV+E L+ K+ADFGLAR+ +D  Y A  G KFPIKWTAPEA     FS+KSDVWSFG+L+ EI+T+GR PYPG+ N  V+ ++ +GYR+P P       P +LY + + CW   PE RPTF +LQ + E +  + E QY
Sbjct:    3 VVALYDFEQLNPDDMGFKKGDKMRIIQERGE-WWMAELMDGSHKGYIPSNYVAKANSLETEEWFFSGVSRKEGERLLLAPGNSIGAYLLRDSESNKGSYSLSVRDYDIT-NGDVVRHYKIRTLDNG-GYFISARLTFPDLFALIQHYTAHSDGLCQKLLRPCVSKKPQQLWEKDAWEIPRDSLKLSKRLGAGQFGEVWMGIYNNRTKVAIKTMKPGSMSPEAFLDEANLMKTLQHPRLVRLYAVVTQ---EPIYIVTEFMENGSLLDYLKSTEGSTLPMPKMIDMAAQIAEGMAFIERKNYIHRDLRAANILVNEQLASKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEIITFGRIPYPGMSNSDVIRQLERGYRMPCPEQ----APKQLYGVMMDCWKERPEERPTFEYLQGVLEDFFTSTEGQY 442

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: clul1 (clusterin-like 1 (retinal) [Source:ZFIN;Acc:ZDB-GENE-031118-57])

HSP 1 Score: 421.394 bits (1082), Expect = 1.007e-141
Identity = 217/460 (47.17%), Postives = 303/460 (65.87%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEA--------WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ Y+AR  DDL F KG+   I ++  E         WW A   +T   GYIPSNYV   D   +  E WY   ++ K+A+++LL  GNP GT++IR    +K  Y+LS+R +D  K   V KHYKIR LDN  G+YI+ R++F  +  L+++Y  + DGLC KLTL CP   KP  Q   +D  E+ RD ++LE  LG G FGEV+ G WN + +VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+  +G+ L+L +++DM +QIA GMAY+E  N++HRDLRAANILV ++L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA M  RF++KSDVWSFG+L+ E+VT GR PYPG+ NR+VL++V +GYR+P P      CP+ L+ + ++CW   PE RPTF +LQ   E +    E QY
Sbjct:   20 ALYDYDARTQDDLSFRKGEKFQIINNTIEVAVVYREGDWWEARSLSTGNKGYIPSNYVAPADSVQA--EEWYFGKVSRKDAERQLLCPGNPRGTFLIRESETTKGAYSLSIRDWDEVKGDNV-KHYKIRKLDNG-GYYITTRAQFDTLQKLVQHYSEHADGLCYKLTLVCPN-EKPQTQGLARDAWEMPRDSLKLELKLGQGCFGEVWAGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS---EEPIYIVTEFMSKGSLLDFLKEGDGRYLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAMFGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPPS----CPESLHELMMQCWKKDPEERPTFEYLQAFLEDYFTATEPQY 467

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 395.971 bits (1016), Expect = 5.073e-132
Identity = 208/451 (46.12%), Postives = 280/451 (62.08%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKT-------GYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPP---IQFKDI---EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVT----DDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQ 1594
            AL+ Y+ R  +DL F +G+L+ ++   +  WW A   T   +       GYIP+NYV   +      E W+  DI   +A+K LL   N  G ++IR     K  Y+LSVR   T      VKHY+IR LD N GF+IS R  F N+  L++YY++N+DGLC  L   C     P    + +  +   E+ R  I+L++ LG G FGEV+ G WNNS  VAVK LKP +M +  FI EA++M +L H  ++Q+  VC+Q  E+P++IITELM +G+LL+YLR P G++L+  E++DM  QIA GMAYLES+N++HRDL A NILV E    KVADFGLAR+     +D Y    G K PIKWTAPEA    RFSVKSDVWSFG+L+YE++TYGR PYP + N +VL ++ +GYR+P P      CP   Y+I L+CW+   E RPTF  LQ
Sbjct:    3 ALYDYDGRTNEDLSFKEGELLEVTDKTNSDWWYAQKKTASTSNERYNTRGYIPANYVA--EYQSLDAEPWFFGDIKRADAEKYLLADVNTTGAFLIRQSESRKTDYSLSVRDGST------VKHYRIRQLDENGGFFISRRVTFQNLIELVQYYKSNSDGLCMALQKPCVVIEAPTTIGLSYNTVDKWEIPRASIQLQKRLGAGMFGEVWQGLWNNSTLVAVKTLKPGAMKKEEFIGEAQIMKQLRHANLIQLYAVCSQ--EEPIYIITELMRHGSLLDYLRGPLGKQLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDN----CPPLFYSIMLECWNKKEEERPTFETLQ 439

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72])

HSP 1 Score: 396.356 bits (1017), Expect = 1.641e-131
Identity = 207/454 (45.59%), Postives = 292/454 (64.32%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVR-HFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC----PQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDD-VYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            V AL+ Y+  H DDL F +GD + I  + ++ WW A    TKK GYIPSN+V   +        +  ++ K+A+++LL  GN IG+Y+IR    +K  Y+LSVR H     +   VKHYKIRTLD   G++I++R  F  +  L+ YY    DGLC KL   C    PQ+   P +    E+ R+ I+LE+ LG G FG+V++G +N   +VAVK +KP SM    F+ EA LM  L H ++V++  V T   ++P+FI+TE M  G+LL++L++ EG +L+  +M+DM +Q+AEGMA++E +N++HRDLRAANILV+ +L  K+ADFGLAR+ +D  Y A  G KFPIKWTAPEA     FS+KSDVWSFG+L+ E+VT+GR PYPG+ N +V+  + +GYR+P P      CP ELY+I  +CW   PE RPTF +LQ + E +    E QY
Sbjct:   68 VVALYDYDPIHADDLCFRRGDQLVIVEEGND-WWKARSVATKKEGYIPSNFVAKVNSIEKEEWFFKGLSRKDAERQLLLCGNKIGSYLIRDSETNKGSYSLSVRDHIVEVGD--TVKHYKIRTLDKG-GYFITSRITFHTLQELVVYYHLKADGLCQKLGKPCIAIQPQK---PWEKDAWEIPRESIKLEKKLGAGQFGDVWMGVYNKKTKVAVKMMKPGSMAPQAFLEEANLMKTLQHDKLVRLHAVVT---DEPIFIVTEYMEKGSLLDFLKTSEGSRLKQPKMIDMCAQVAEGMAFIEDKNYIHRDLRAANILVNVNLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEMVTFGRIPYPGMTNPEVIRSLERGYRMPKPDN----CPCELYSIMQECWRQKPEERPTFEYLQSLLEDFYTATELQY 507

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BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006670.1 (pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene:ENSPMAG00000006016.1 transcript:ENSPMAT00000006670.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 358.992 bits (920), Expect = 1.122e-118
Identity = 178/369 (48.24%), Postives = 245/369 (66.40%), Query Frame = 2

Query:  521 KLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ------FKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARV----TDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQ 1594
            +L++ GN  G++++R    S H Y+LSVR  DT      VKHYKIR L+    F+I+ R++F  +  L++ Y  + +GLC  L   C ++  P  +          E+ R  ++L + LG G FGEV+ G WN +  VA+K LK  +MDR  F+ EA+LM +L HP+++Q+  VCTQ  E+P++IITELM+NG+L NYL++PEG+ L L E++DM +Q+A GMAYLE++N++HRDL A NILV E  + KVADFGLARV     +D Y A  G+KFPIKWTAPEA    RFS+KSDVWSFGVL++EI+TYG+ PYPG  N +VL  V +GYR+P P G    CP   Y + L+CW+   + RPTF  LQ
Sbjct:    9 QLMKSGNVHGSFLVRQSETSGHGYSLSVRDGDT------VKHYKIRVLEKG-SFFITRRNQFATLRDLVQSYSRDANGLCVTLNQPCLKKEMPQTEGLSSDMADKWEIPRSSVQLVKRLGAGQFGEVWQGLWNKTTPVAIKTLKQGTMDRDDFLREAQLMKRLRHPKLIQLYAVCTQ--EEPIYIITELMSNGSLANYLQTPEGRSLDLVELVDMAAQVAAGMAYLEAQNYIHRDLAARNILVAEHNACKVADFGLARVIKMSNEDEYEARVGSKFPIKWTAPEAANYNRFSIKSDVWSFGVLLHEIITYGKLPYPGQTNAEVLAAVDRGYRMPCPPG----CPQAFYDLMLECWNVDDQARPTFETLQ 364

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BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 103.99 bits (258), Expect = 2.148e-23
Identity = 86/265 (32.45%), Postives = 131/265 (49.43%), Query Frame = 2

Query:  842 LERVLGNGSFGEVY--LGKWNNSVEVAVKQLK-PNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYL-RSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINA 1624
            L++V+G GS+G VY  + K  + V VA+K++   N  + +  +AE  L+  LNH  IV+  G   +  E  ++I+ E  ANG+L   + RS  G  L  NE    ++Q   G+ YL     +HRD++AANIL+  D +VK+ADFG++ + +       GT   + W APE    R  S  SD+WS G  + E++T    PY  + +  +   V      P P+       D L     KC+      RPT   L    +H  IN+
Sbjct:   27 LKQVIGRGSYGVVYKAINKHTDQV-VAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYE--LYILLEYCANGSLRRLISRSSTG--LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGT---LNWMAPEILGNRGASTLSDIWSLGATVVEMLT-KNPPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLS----KCFVKNMYKRPTADQL---LKHVWINS 274

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BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 100.908 bits (250), Expect = 2.782e-23
Identity = 68/221 (30.77%), Postives = 120/221 (54.30%), Query Frame = 2

Query:  791 KPPIQFKDI--EVSRDCIRLERVLGNGSFGEVYLGKWN-NSVEVAVKQLKPNSMDRSRFIA----EAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPY 1432
            KP +Q++D   + S    ++ R LG GSFG V+L + N N    A+K LK +++ + + +     E  ++  ++HP I+++ G  T    Q VF++ + +  G L + LR  + Q+          +++   + YL S++ ++RDL+  NIL+D++  +K+ DFG A+   DV     GT     + APE    + ++   D WSFGVL+YE++  G TP+
Sbjct:   71 KPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWG--TFQDSQQVFMVMDYIEGGELFSLLR--KSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTP---DYIAPEVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPF 283

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BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 103.219 bits (256), Expect = 4.771e-23
Identity = 79/268 (29.48%), Postives = 138/268 (51.49%), Query Frame = 2

Query:  851 VLGNGSFGEVYLGKWNNSVEV-AVKQLK-PNSMDRSRFI--------AEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEML--DMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVY-NADTGTKFPIKWTAPE-AGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKL-------KCWDAYPENRPTFSHL 1591
            ++G GSFG VYL     + E+ AVKQ++ P    ++  I        +E   +  L+H  IVQ LG   +     +F+  E +A G++ + +R       R +E L   + +Q+ +G+AYL S+  +HRD++A N+L+D+D   K++DFG++R + D+Y N+D   +  + W APE    ++ +S K D+WS G ++ E+   G+ P+        L+ V+  +++        +  D L  I          C++  PE RPT + L
Sbjct: 1180 MIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFL--EYVAGGSVGSLIR----MYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWSN------LEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANEL 1434

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BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952])

HSP 1 Score: 88.5817 bits (218), Expect = 1.113e-19
Identity = 71/230 (30.87%), Postives = 116/230 (50.43%), Query Frame = 2

Query:  839 RLERVLGNGSFGEVYLG-KWNNSVEVAVKQLKPNSMDR--SRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRS------PEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGM-QRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPA 1498
            +LE+ LGNG++  VY G      V VA+K++K +S +   S  I E  LM +L H  IV++  V     E  + ++ E M N  L  Y+ S      P G  L LN +     Q+ +G+A+      +HRDL+  N+L+++   +K+ DFGLAR      N  +     + + AP+  M  R +S   D+WS G ++ E++T G+  +PG  + + L  +      PN +
Sbjct:    9 QLEK-LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHT--ENKLTLVFEFMDND-LKKYMDSRTVGNTPRG--LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNES 231

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BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 88.9669 bits (219), Expect = 2.055e-19
Identity = 61/200 (30.50%), Postives = 105/200 (52.50%), Query Frame = 2

Query:  848 RVLGNGSFGEVYLGK-WNNSVEVAVKQLKPNSMDRSRFIA----EAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPY 1432
            R LG GSFG V+L +  +N    A+K LK   + R + +     E  ++  + HP I+++ G       Q +F+I + +  G L + LR  + Q+          +++   + YL S++ ++RDL+  NIL+D++  +K+ DFG A+   DV     GT     + APE    + ++   D WSFG+L+YE++  G TP+
Sbjct:   91 RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDA--QQIFMIMDYIEGGELFSLLR--KSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTP---DYIAPEVVSTKPYNKSIDWWSFGILIYEMLA-GYTPF 282

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BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18])

HSP 1 Score: 264.618 bits (675), Expect = 1.925e-83
Identity = 134/290 (46.21%), Postives = 185/290 (63.79%), Query Frame = 2

Query:  818 EVSRDCIRLERVLGNGSFGEVYLGKWNN-SVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQD----IFEHWEINAESQYFS*FSIVLFFH 1669
            E+ R  I ++  LG G +GEVY G W   +  VAVK L+  +M+   F+ EA +M  + H  +VQ+LGVCT+ P  P +IITE M NG LL+YLRSP+G+ L    ++ M +Q+   M+YLES NF+HRDL A N LV ++  VKVADFGL+R V++D+Y A  G KFPIKWTAPEA     FS+KSDVW+FG+L++E+ TYG +PYPGI   QV D++  GYR+P P G    CP E+Y++   CW   P +RP+F  + +    +F    +N E  Y S   +  + H
Sbjct:    8 EIERTEIAMKHKLGGGQYGEVYEGTWKKYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREP--PFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEG----CPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSNVN-EGVYISYIKVYFYIH 290

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BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO49804 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFY7])

HSP 1 Score: 219.935 bits (559), Expect = 2.011e-67
Identity = 109/221 (49.32%), Postives = 143/221 (64.71%), Query Frame = 2

Query:  893 WNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCW 1552
            W  ++ VAVK +K  +M    FI EA++M +  H  +VQ+ G+C+   E+P++II ELM  G LL+YLR  +  KL+  EM +M+ Q+A  M YLES NF+HRDL A N L+ E+ +VKVADFGLAR V DD Y A  GTKFPIKW APE  +  +FS KSDVW+FG+L +E+ T G+ PYP   N  V+  V  GYRL  P    + CPD  Y+   KCW
Sbjct:    2 WRGTIPVAVKMMKDGAMSEEDFIEEAKVMKQFQHGNLVQLYGICS---EKPIYIIQELMKGGCLLHYLRKSQF-KLQSAEMTEMVRQVAAAMKYLESHNFIHRDLAARNCLIGENRTVKVADFGLARYVIDDEYTASEGTKFPIKWAAPEVILYSKFSSKSDVWAFGILAWEVYTGGKQPYPATNNTDVVQMVINGYRLEKP----LRCPDAAYSTMRKCW 214

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BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8])

HSP 1 Score: 216.083 bits (549), Expect = 1.768e-63
Identity = 112/262 (42.75%), Postives = 163/262 (62.21%), Query Frame = 2

Query:  818 EVSRDCIRLERVLGNGSFGEVYLGKWN----NSVEVAVKQLKPNSMDRSR--FIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFS 1585
            E+ +  ++LE+V+G G FG+VY G       N++ VA+K LK  S  ++R  F++EA +M +   P ++ + GV ++    P+ I+TE M+NG+L N+L+  +  KL L +++ M   IA GM YL   NFVHRDL A NILV E L  KVADFGL+R  +D     +G K P++WTAPEA   R+FS  SDVWS+G+L++E  ++   PY    N +V+D V  GYRLP P    + CP  ++ I L+CWDA    RP+F+
Sbjct:   52 ELDKRWLKLEKVIGGGEFGDVYKGTLKRPGENTIPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKT--HPLMIVTEFMSNGSLDNFLKKMD-SKLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSRELEDSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPP----MSCPKVIHQIMLECWDADRTKRPSFA 306

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BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7])

HSP 1 Score: 215.312 bits (547), Expect = 1.973e-63
Identity = 114/276 (41.30%), Postives = 171/276 (61.96%), Query Frame = 2

Query:  818 EVSRDCIRLERVLGNGSFGEVYLGKWNN----SVEVAVKQLKPNSMDRSR--FIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADT------GTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEH 1609
            E+++D ++LE ++G G F +VY G   N      +VAVK LKP S  ++R  F  EA +M + +HP ++ + GV T+   +P+ IITE + NG+L N+L+S +G+   L +++ +   +A GMAYL   NF+HRDL A NILV ++L+ KV+DFGL+R  DD    +       G K P++WTAPEA   R+FS  SDVWS+G+L++EI+++G  PY    N QV+D V  GYRLP P    + CP  ++ + L CWD    +RP F+ +   F+ 
Sbjct:   21 EINKDDLKLEIIIGGGEFADVYRGVLTNEDKTQEKVAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRT--RPMMIITEFLENGSLDNFLKSNDGRLTTL-QLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAP----MKCPKVIHNLMLDCWDKEKTSRPKFADIVRRFDE 289

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BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO33732 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD3])

HSP 1 Score: 196.823 bits (499), Expect = 2.890e-58
Identity = 105/238 (44.12%), Postives = 153/238 (64.29%), Query Frame = 2

Query:  818 EVSRDCIRLERVLGNGSFGEVYLGKWNN----SVEVAVKQLKPNSMDRSR--FIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADT------GTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNP 1495
            E+++D ++LE V+G G F +VY G   N      +VAVK LKP S  ++R  F  EA +M + +HP ++ + GV T+   +P+ IITE + NG+L N+L+S +G +L   +++ +   +A GMAYL   NF+HRDL A NILV ++L+ KV+DFGL+R  DD    +       G K P++WTAPEA   R+FS  SDVWS+G+L++EI+++G  PY    N QV+D V  GYRLP P
Sbjct:   22 EINKDDLKLEIVIGGGEFADVYRGVLTNEDKTQEKVAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRT--RPMMIITEFLENGSLENFLKSNDG-RLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAP 256

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BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: yrk (proto-oncogene tyrosine-protein kinase Yrk [Source:NCBI gene;Acc:101155365])

HSP 1 Score: 424.091 bits (1089), Expect = 2.599e-141
Identity = 214/454 (47.14%), Postives = 303/454 (66.74%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC----PQRHKPPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ Y+AR  DDL F KG+   I ++    WW A    T K+GYIPSNYV   D   +  E WY   +  K+A+++LL  GNP GT++IR    +K  Y+LS+R +D TK  +V KHYKIR LDN  G+YI+ RS+F  +  L+++Y     GLCC+L  SC    P+     ++ KD+ E+ R+ ++L + LGNG FGEV++G WN + +VAVK LKP +M    F+ EA++M +L H ++VQ+  V +   E+P++IITE M+ G+LL++L+  EGQ L+L +++DM +QIA GMAY+E  N++HRDLRAANILV ++L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E++T GR PYPG+ NR+VL++V +GYR+P   G    CP  L+ + L+CW   P+ R TF +LQ   E +    E QY
Sbjct:   81 ALYDYDARTEDDLTFQKGEKFQIINNTEGDWWEARSLDTGKSGYIPSNYVAPIDSIQA--EEWYFGKMGRKDAERQLLGQGNPRGTFLIRESETTKGAYSLSIRDWDDTKGDHV-KHYKIRKLDNG-GYYITTRSQFDTVQQLVEHYTERAAGLCCRLIGSCKRGMPKLADLSVKTKDMWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVS---EEPIYIITEFMSEGSLLDFLKDGEGQTLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCAPG----CPASLHELMLQCWRREPDERHTFEYLQSFLEDYFTATEPQY 523

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: SRC (SRC proto-oncogene, non-receptor tyrosine kinase [Source:NCBI gene;Acc:101173856])

HSP 1 Score: 422.55 bits (1085), Expect = 1.837e-140
Identity = 218/455 (47.91%), Postives = 301/455 (66.15%), Query Frame = 2

Query:  293 TVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            T  AL+ YE+R   DL F KGD + I ++    WWLA   TT ++GYIPSNYV   D   +  E WY   IT +++++ LL + N  GT+++R    +K  Y LSV  +D  K   V KHYKIR LD+  GFYI++R++F ++  L+ +Y+ ++DGLC  LT  CP   KP  Q   +D  E+ R+ +RL+  LG G FGEV++G WN +  VA+K LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+   G+ LRL +++DM +QIA GMAY+E  N+VHRDLRAANILV ++L  KVADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFGVL+ E+ T GR PYPG+ NR+VLD+V +GYR+P PA     CP  L+ + L CW   PE RPTF +LQ   E +  + E QY
Sbjct:   96 TFVALYDYESRTASDLTFRKGDRLQIVNNTEGDWWLARSLTTGESGYIPSNYVAPSDSIQA--EEWYFGKITRRDSERLLLNLQNRRGTFLVRESETTKGAYCLSVLDYDNAKGLNV-KHYKIRKLDSG-GFYITSRTQFTSLQQLVFHYRKHSDGLCHALTDVCPV-AKPQTQGLARDAWEIPRESLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSQGSLLDFLKGDTGKLLRLPQLVDMAAQIAAGMAYVEKMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCPA----ECPSSLHELMLSCWRKDPEERPTFEYLQGFLEDYFTSTEPQY 538

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: YES1 (YES proto-oncogene 1, Src family tyrosine kinase [Source:NCBI gene;Acc:101158313])

HSP 1 Score: 421.009 bits (1081), Expect = 7.588e-140
Identity = 215/452 (47.57%), Postives = 301/452 (66.59%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSKH-YALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQ--FKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ YEAR +DDL F KGD   I ++    WW A   TT K GYIPSNYV   D   +  E WY   +  K+A++ LL  GN  GT+++R    +K  Y+LS+R +D+ K   V KHYKIR LDN  G+YI+ R++F  +  L+K+Y  + DGLC +LT  CP   KP  Q   KD  E+SR+ ++LE  LG G FGEV++G WN + +VA+K LKP +M    F+ EA++M KL H ++V +  V +   E+P++I+TE M+ G+LL++L+  EG+ L L  ++DM ++IA+GMA++E  N++HRDLRAANILV ++L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E+VT GR PYPG+ NR+VL++V +GYR+P P G    CP+ L+ +   CW   P+ RPTF +LQ   E +  + E QY
Sbjct:  105 ALYDYEARTSDDLTFKKGDRFQIINNTEGDWWEARSITTGKKGYIPSNYVAPADSIQA--EEWYFGKMGRKDAERLLLNPGNDRGTFLVRESETTKGAYSLSIRDWDSAKGDNV-KHYKIRKLDNG-GYYITTRAQFDTLQKLVKHYTEHADGLCHRLTTVCPTV-KPQTQGLAKDAWEISRESLQLELKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLFAVVS---EEPIYIVTEYMSKGSLLDFLKEGEGKFLNLVMLVDMAAKIADGMAFIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG----CPESLHEMMKLCWKKEPDERPTFEYLQSFLEDYFTSTEPQY 544

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BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: fyna (tyrosine-protein kinase fyna [Source:NCBI gene;Acc:101157019])

HSP 1 Score: 417.927 bits (1073), Expect = 9.230e-139
Identity = 209/454 (46.04%), Postives = 298/454 (65.64%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSC----PQRHKPPIQFKDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ YEAR  DDL F KG+   I +     WW A   TT  TGYIPSNYV   D   +  E WY   +  K+A+++LL  GN  GT++IR    +K  Y+LS++ +D  K  +V KHYKIR LDN  G+YI+ R++F  +  L+++Y     GLCC+L   C    P+     ++ KD+ E+ R+ ++L + LGNG FGEV++G WN + +VAVK LKP +M    F+ EA++M KL H ++VQ+  V +   E+P++I+TE M+ G+LL++L+  EG+ L+L  ++DM +Q+A GMAY+E  N++HRDLR+ANILV + L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  +F++KSDVWSFG+L+ E+VT GR PYPG+ NR+VL++V +GYR+P P      CP  L+ + ++CW   PE RPTF +LQ   E +    E QY
Sbjct:   89 ALYDYEARTEDDLSFRKGERFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQA--EDWYFGKLGRKDAERQLLSSGNARGTFLIRESETTKGAYSLSIQDWDDIKGDHV-KHYKIRKLDNG-GYYITTRAQFETLQQLVQHYSARAAGLCCRLIAPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDGLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQD----CPTSLHELMVQCWKKDPEERPTFEYLQAFLEDYFTATEPQY 531

[Close]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: yrk (proto-oncogene tyrosine-protein kinase Yrk [Source:NCBI gene;Acc:101155365])

HSP 1 Score: 417.542 bits (1072), Expect = 1.023e-138
Identity = 214/453 (47.24%), Postives = 301/453 (66.45%), Query Frame = 2

Query:  302 ALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWY--DITHKEADKKLLRMGNPIGTYIIRPCSDSK-HYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQF---KDI-EVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLAR-VTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            AL+ Y+AR  DDL F KG+   I ++    WW A    T K+GYIPSNYV   D   +  E WY   +  K+A+++LL  GNP GT++IR    +K  Y+LS+R +D TK  +V KHYKIR LDN  G+YI+ RS+F  +  L+++Y  + DGLC  LT SCP  +  P+     +D  EV R+ + L++ LG G FG+V +G WN + +VAVK LKP +M    F+ EA++M +L H ++VQ+  V +   E+P++IITE M+ G+LL++L+  EGQ L+L +++DM +QIA GMAY+E  N++HRDLRAANILV ++L  K+ADFGLAR + D+ Y A  G KFPIKWTAPEA +  RF++KSDVWSFG+L+ E++T GR PYPG+ NR+VL++V +GYR+P   G    CP  L+ + L+CW   P+ R TF +LQ   E +    E QY
Sbjct:   81 ALYDYDARTEDDLTFQKGEKFQIINNTEGDWWEARSLDTGKSGYIPSNYVAPIDSIQA--EEWYFGKMGRKDAERQLLGQGNPRGTFLIRESETTKGAYSLSIRDWDDTKGDHV-KHYKIRKLDNG-GYYITTRSQFDTVQQLVEHYTGSNDGLCYYLTKSCP--NSVPLTMGLARDAWEVPRETLTLQKKLGQGCFGDVCMGMWNGTTKVAVKTLKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVS---EEPIYIITEFMSEGSLLDFLKDGEGQTLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCAPG----CPASLHELMLQCWRREPDERHTFEYLQSFLEDYFTATEPQY 520

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000045588.1 (SMESG000045588.1)

HSP 1 Score: 1042.72 bits (2695), Expect = 0.000e+0
Identity = 517/517 (100.00%), Postives = 517/517 (100.00%), Query Frame = 2

Query:   92 MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMXXXXXXXXXXXXXXXXXXVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYFS 1642
            MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMILSPPLQQQMIPSSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYFS
Sbjct:    1 MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMILSPPLQQQMIPSSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYFS 517

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000029204.1 (SMESG000029204.1)

HSP 1 Score: 1042.72 bits (2695), Expect = 0.000e+0
Identity = 517/517 (100.00%), Postives = 517/517 (100.00%), Query Frame = 2

Query:   92 MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMXXXXXXXXXXXXXXXXXXVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYFS 1642
            MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMILSPPLQQQMIPSSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYFS
Sbjct:    1 MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMILSPPLQQQMIPSSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQYFS 517

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000060646.1 (SMESG000060646.1)

HSP 1 Score: 659.062 bits (1699), Expect = 0.000e+0
Identity = 307/447 (68.68%), Postives = 366/447 (81.88%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            VRAL++Y   +  DL F KGD+M +SSD++E WW A H    +TGYIPSNYV +DDG+P+SHE W+DI H EAD+KLL MGNP GTYIIRP SDS++ ALS+RHFD  +N+YVVKHYKIRTLDN  G+YIS+R+ FP+I +LI +Y  +TDGLCC+LT   P++HKPP QF++IEV+R CI L R LGNGSFGEV+LGKWN+ +EVAVK ++PN MD   F+ EA+LMHKL+HPRIVQILGVCT+P   P++IITELMA GALLN+LR  EGQKL L +ML M+SQIAEGMAYLES+ FVHRDLRAANILV +DLSVKVADFGLAR+T+D Y AD GTKFPIKWTAPEAG++R FSVKSDVWSFGVLM+EI+TYGRTPY G  N +VL+EVS+GYRLPNP GGKI CP ELY I L CWDA  E RPTFS L+D FE++ I  E QY
Sbjct:   42 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNG-GYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 487

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000060646.1 (SMESG000060646.1)

HSP 1 Score: 652.129 bits (1681), Expect = 0.000e+0
Identity = 302/447 (67.56%), Postives = 366/447 (81.88%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            VRAL++Y   +  DL F KGD+M +SSD++E WW A H    +TGYIPSNYV +DDG+P+SHE W+DI H EAD+KLL MGNP GTYIIRP SDS++ ALS+RHFD  +N+YVVKHYKIRTLDN  G+YIS+R+ FP+I +LI +Y  +TDGLCC+LT   P++HKPP QF++IEV+R CI L R LGNGSFGEV+LGKWN+ +EVAVK ++PN MD   F+ EA+LMHKL+HPRIVQILGVCT+P   P++IITELMA GALLN+LR  EGQKL L +ML M+SQIAEGMAYLES+ FVHRDLRAANILV +DLSVKVADFGLAR+T+D Y AD GTKFPIKWTAPEAG++R FSVKSDVWSFGVLM+EI+TYGRTPY G PN +VL+ VS+GYRLPNP G +IVCP  LY I L CWDA  E RPTFS+++D+F+++ I  E  Y
Sbjct:   42 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNG-GYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFPNNKVLESVSRGYRLPNPHGERIVCPRLLYNIMLSCWDAISEKRPTFSYMKDVFDNFAIANEPLY 487

[Close]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000060646.1 (SMESG000060646.1)

HSP 1 Score: 650.588 bits (1677), Expect = 0.000e+0
Identity = 304/447 (68.01%), Postives = 370/447 (82.77%), Query Frame = 2

Query:  296 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 1636
            VRAL++Y+ R+  DL F+KGD+++++S+M++ WW+A H+ T   GYIPSNYVV+DDGSP+S EG+++I H EADKKLL MG   GTYIIRP SDS++ ALS+RHFD  +N+YVVKHYKIRTLDN  G+YIS+R+ FP+I +LI +Y  +TDGLCC+LT   P++HKPP QF++IEV+R CI L R LGNGSFGEV+LGKWN+ +EVAVK ++PN MD   F+ EA+LMHKL+HPRIVQILGVCT+P   P++IITELMA GALLN+LR  EGQKL L +ML M+SQIAEGMAYLES+ FVHRDLRAANILV +DLSVKVADFGLAR+T+D Y AD GTKFPIKWTAPEAG++R FSVKSDVWSFGVLM+EI+TYGRTPY G  N +VL+EVS+GYRLPNP GGKI CP ELY I L CWDA  E RPTFS L+D FE++ I  E QY
Sbjct:   30 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNG-GYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 475

The following BLAST results are available for this feature:

BLAST of Tyrosine-protein kinase vs. Ensembl Human
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
BLAST of Tyrosine-protein kinase vs. TrEMBL
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
BLAST of Tyrosine-protein kinase vs. Planmine SMEST

BLAST of Tyrosine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SRC	9.685e-144	48.57	SRC proto-oncogene, non-receptor tyrosine kinase [...	[more]
SRC	9.685e-144	48.57	SRC proto-oncogene, non-receptor tyrosine kinase [...	[more]
SRC	9.685e-144	48.57	SRC proto-oncogene, non-receptor tyrosine kinase [...	[more]
SRC	1.032e-141	48.37	SRC proto-oncogene, non-receptor tyrosine kinase [...	[more]
HCK	1.117e-140	47.78	HCK proto-oncogene, Src family tyrosine kinase [So...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
src-1	7.118e-134	44.11	Tyrosine protein-kinase src-1 [Source:UniProtKB/S...	[more]
src-1	2.429e-133	44.11	Tyrosine protein-kinase src-1 [Source:UniProtKB/S...	[more]
src-1	2.429e-133	44.11	Tyrosine protein-kinase src-1 [Source:UniProtKB/S...	[more]
src-1	2.666e-133	44.11	Tyrosine protein-kinase src-1 [Source:UniProtKB/S...	[more]
src-1	2.666e-133	44.11	Tyrosine protein-kinase src-1 [Source:UniProtKB/S...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Src42A	7.230e-129	46.07	gene:FBgn0264959 transcript:FBtr0335275	[more]
Src64B	6.108e-127	42.14	gene:FBgn0262733 transcript:FBtr0100508	[more]
Src64B	6.108e-127	42.14	gene:FBgn0262733 transcript:FBtr0100505	[more]
Src64B	6.108e-127	42.14	gene:FBgn0262733 transcript:FBtr0100504	[more]
Src64B	6.108e-127	42.14	gene:FBgn0262733 transcript:FBtr0304990	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lyn	1.062e-144	49.24	LYN proto-oncogene, Src family tyrosine kinase [So...	[more]
src	8.394e-143	48.35	v-src avian sarcoma (Schmidt-Ruppin A-2) viral onc...	[more]
src	8.394e-143	48.35	v-src avian sarcoma (Schmidt-Ruppin A-2) viral onc...	[more]
fyna	3.077e-141	46.92	FYN proto-oncogene, Src family tyrosine kinase a [...	[more]
src	3.188e-140	47.72	v-src avian sarcoma (Schmidt-Ruppin A-2) viral onc...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cthrc1	7.991e-144	48.35	collagen triple helix repeat containing 1 [Source:...	[more]
cthrc1	9.032e-144	48.35	collagen triple helix repeat containing 1 [Source:...	[more]
cthrc1	1.015e-143	48.35	collagen triple helix repeat containing 1 [Source:...	[more]
cthrc1	2.274e-143	48.35	collagen triple helix repeat containing 1 [Source:...	[more]
cthrc1	2.296e-143	48.35	collagen triple helix repeat containing 1 [Source:...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Src	2.301e-143	48.57	Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:9...	[more]
Src	2.301e-143	48.57	Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:9...	[more]
Src	2.301e-143	48.57	Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:9...	[more]
Src	2.347e-141	48.37	Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:9...	[more]
Src	2.347e-141	48.37	Rous sarcoma oncogene [Source:MGI Symbol;Acc:MGI:9...	[more]

BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P42687\|SPK1_GIRTI	4.597e-143	47.50	Tyrosine-protein kinase SPK-1 OS=Girardia tigrina ...	[more]
sp\|P12931\|SRC_HUMAN	4.651e-143	48.57	Proto-oncogene tyrosine-protein kinase Src OS=Homo...	[more]
sp\|P13116\|SRC2_XENLA	4.914e-143	48.35	Tyrosine-protein kinase Src-2 OS=Xenopus laevis OX...	[more]
sp\|P00523\|SRC_CHICK	1.092e-142	48.79	Proto-oncogene tyrosine-protein kinase Src OS=Gall...	[more]
sp\|Q9WUD9\|SRC_RAT	1.792e-142	48.57	Proto-oncogene tyrosine-protein kinase Src OS=Ratt...	[more]

BLAST of Tyrosine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G7YFZ5	0.000e+0	63.39	Tyrosine-protein kinase OS=Clonorchis sinensis OX=...	[more]
A0A4S2LUM5	0.000e+0	63.39	Tyrosine-protein kinase OS=Opisthorchis felineus O...	[more]
A0A074ZSJ9	0.000e+0	63.39	Tyrosine-protein kinase OS=Opisthorchis viverrini ...	[more]
C1LGZ6	0.000e+0	62.50	Tyrosine-protein kinase OS=Schistosoma japonicum O...	[more]
A0A094ZT02	0.000e+0	62.28	Tyrosine-protein kinase OS=Schistosoma haematobium...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
fyna	1.579e-140	46.70	tyrosine-protein kinase fyna [Source:NCBI gene;Acc...	[more]
src	4.821e-140	47.62	proto-oncogene tyrosine-protein kinase Src [Source...	[more]
src	2.568e-139	47.94	proto-oncogene tyrosine-protein kinase Src [Source...	[more]
clul1	7.516e-139	47.35	tyrosine-protein kinase yes [Source:NCBI gene;Acc:...	[more]
SRC	1.098e-138	46.75	proto-oncogene tyrosine-protein kinase Src-like [S...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hck	1.828e-142	47.33	HCK proto-oncogene, Src family tyrosine kinase [So...	[more]
clul1	1.007e-141	47.17	clusterin-like 1 (retinal) [Source:ZFIN;Acc:ZDB-GE...	[more]
frk	5.073e-132	46.12	fyn-related Src family tyrosine kinase [Source:ZFI...	[more]
hck	1.641e-131	45.59	HCK proto-oncogene, Src family tyrosine kinase [So...	[more]
ENSPMAT00000006670.1	1.122e-118	48.24	pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
CDC15	2.148e-23	32.45	Protein kinase of the Mitotic Exit Network; locali...	[more]
TPK3	2.782e-23	30.77	cAMP-dependent protein kinase catalytic subunit; p...	[more]
BCK1	4.771e-23	29.48	MAPKKK acting in the protein kinase C signaling pa...	[more]
PHO85	1.113e-19	30.87	Cyclin-dependent kinase; has ten cyclin partners; ...	[more]
TPK1	2.055e-19	30.50	cAMP-dependent protein kinase catalytic subunit; p...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO47195	1.925e-83	46.21	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49804	2.011e-67	49.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40994	1.768e-63	42.75	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33736	1.973e-63	41.30	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33732	2.890e-58	44.12	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
yrk	2.599e-141	47.14	proto-oncogene tyrosine-protein kinase Yrk [Source...	[more]
SRC	1.837e-140	47.91	SRC proto-oncogene, non-receptor tyrosine kinase [...	[more]
YES1	7.588e-140	47.57	YES proto-oncogene 1, Src family tyrosine kinase [...	[more]
fyna	9.230e-139	46.04	tyrosine-protein kinase fyna [Source:NCBI gene;Acc...	[more]
yrk	1.023e-138	47.24	proto-oncogene tyrosine-protein kinase Yrk [Source...	[more]

BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000045588.1	0.000e+0	100.00	SMESG000045588.1	[more]
SMESG000029204.1	0.000e+0	100.00	SMESG000029204.1	[more]
SMESG000060646.1	0.000e+0	68.68	SMESG000060646.1	[more]
SMESG000060646.1	0.000e+0	67.56	SMESG000060646.1	[more]
SMESG000060646.1	0.000e+0	68.01	SMESG000060646.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30026402 ID=SMED30026402|Name=Tyrosine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2044bp
TTTGGAAATAAACTTTAAGTTTGAGTGAAAGTTAAATAAGAAATATTTGT
TTATTAAATAAATGAAAAACTTTCATAATTATTTTTGAAAGATGGGTAAC
TGCTTGTCAATTGAAAACAACCAGAAACAACAATATCCAAAACCAAGTAA
CAGAGAAAAAAGTTATAATTTTGAAGTAACTAATATTTCCCAAAATAATT
CTGAAACACAACAAATGATTCTTTCTCCTCCTTTACAACAACAAATGATT
CCTTCATCTCCAATACCTCCAGTCATGTATAATCAGAGACCAACTGTTAG
AGCATTATTTTCTTACGAAGCTCGTCACACAGATGATTTGGAATTTAGTA
AAGGGGATTTAATGTATATTTCATCAGACATGTCAGAAGCTTGGTGGCTT
GCTTTACATGCAACTACTAAAAAAACTGGATATATTCCAAGTAATTATGT
CGTTCTTGATGATGGTTCACCATCTAGTCACGAAGGATGGTATGATATTA
CTCATAAAGAAGCTGATAAGAAATTATTAAGAATGGGTAACCCAATTGGT
ACATATATAATTAGACCATGTTCTGACTCTAAACATTACGCTTTATCTGT
TCGTCATTTTGATACCACTAAAAATTATTACGTTGTTAAGCATTACAAAA
TTCGAACATTAGATAATAATTTGGGATTTTATATTAGTAACAGATCGAAA
TTTCCCAATATTAGTAGCCTTATCAAATATTACCAAACTAATACCGATGG
ATTGTGCTGCAAATTAACACTGTCCTGTCCTCAGAGGCACAAACCTCCGA
TTCAATTTAAAGATATTGAAGTTAGTCGAGATTGTATTCGTTTGGAAAGA
GTTTTGGGAAATGGAAGCTTTGGAGAAGTTTACCTTGGTAAATGGAATAA
TTCTGTCGAGGTTGCCGTTAAACAATTGAAGCCAAATTCTATGGATAGGA
GTCGGTTTATAGCTGAAGCTGAACTGATGCATAAATTGAATCATCCGAGA
ATCGTACAAATTCTCGGAGTTTGTACACAACCCCCAGAGCAGCCAGTTTT
TATTATCACCGAATTAATGGCTAACGGAGCACTTCTGAATTATTTGCGCA
GTCCAGAAGGCCAAAAATTGAGACTAAATGAAATGCTTGACATGATGTCC
CAAATTGCCGAAGGAATGGCATATCTTGAATCGAGAAATTTCGTTCATCG
TGACTTGCGCGCTGCCAATATTTTGGTTGATGAAGATCTTTCAGTGAAAG
TTGCGGATTTCGGATTGGCCAGAGTCACTGATGACGTGTATAACGCTGAC
ACAGGTACTAAATTCCCCATCAAATGGACTGCGCCAGAAGCCGGAATGCA
GCGGAGATTCAGTGTCAAATCCGACGTCTGGTCGTTCGGGGTGTTGATGT
ATGAGATCGTAACATACGGCAGAACTCCCTATCCAGGAATTCCCAATCGG
CAGGTGTTGGACGAGGTCAGCAAAGGCTATCGATTACCGAATCCGGCCGG
TGGAAAGATTGTTTGTCCCGATGAGTTGTATGCAATAAAATTGAAATGCT
GGGACGCCTATCCGGAAAACAGGCCGACCTTCAGTCATTTACAAGATATT
TTTGAGCACTGGGAAATCAATGCAGAGTCTCAATATTTCAGTTGATTTTC
AATTGTTTTGTTTTTTCATTGGTTGATCGCAGCAGCCAATTTGTCATATA
GATCTTCAAGAAAATTTTTTTTCACGTTCGATTTTTTGTTAATTTGCATT
TTTTTAAATATCATGTATTTTTCAATAATTTACTAGCAGTCGATTGGTCT
CCTTTTGCATATTGCCAACAGCCAATAGAAATGCAGGATAATTATTTTAA
TTGGTGTATATAGTTCGACGATAATAGTAATATTAATGATGCTAAAGAAG
CTCAAGATAAGATAAATTATTTTAACATTACAAAATTGTAAAGCAATAAT
TGAACGTTTGATAAAATATATATTACGTAACTTTTTATTGATTTATAATT
TTTTCGTTTATGTTCCCCATTTTGATTTTACTACTATATTTGAT

protein sequence of SMED30026402-orf-1

>SMED30026402-orf-1 ID=SMED30026402-orf-1|Name=SMED30026402-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=518bp
MGNCLSIENNQKQQYPKPSNREKSYNFEVTNISQNNSETQQMILSPPLQQ
QMIPSSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEA
WWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGN
PIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISN
RSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIR
LERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLN
HPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLD
MMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVY
NADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGI
PNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHL
QDIFEHWEINAESQYFS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000034	epidermis

Vocabulary: **INTERPRO**
Term	Definition
IPR036860	SH2_dom_sf
IPR036028	SH3-like_dom_sf
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR001452	SH3_domain
IPR000980	SH2
IPR020635	Tyr_kinase_cat_dom
IPR008266	Tyr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR000719	Prot_kinase_dom
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001452	SH3 domain	PRINTS	PR00452	SH3DOMAIN	coord: 81..96 score: 31.71 coord: 111..123 score: 46.57 coord: 67..77 score: 40.18
IPR001452	SH3 domain	SMART	SM00326	SH3_2	coord: 67..124 e-value: 5.1E-17 score: 72.5
IPR001452	SH3 domain	PFAM	PF00018	SH3_1	coord: 70..117 e-value: 1.0E-11 score: 44.3
IPR001452	SH3 domain	PROSITE	PS50002	SH3	coord: 64..125 score: 24.956
IPR000980	SH2 domain	PRINTS	PR00401	SH2DOMAIN	coord: 152..162 score: 26.49 coord: 181..191 score: 55.22 coord: 163..174 score: 36.27 coord: 203..217 score: 26.21
IPR000980	SH2 domain	SMART	SM00252	SH2_5	coord: 131..220 e-value: 8.5E-20 score: 81.8
IPR000980	SH2 domain	PFAM	PF00017	SH2	coord: 135..214 e-value: 3.5E-13 score: 49.4
IPR000980	SH2 domain	PROSITE	PS50001	SH2	coord: 136..229 score: 16.158
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PRINTS	PR00109	TYRKINASE	coord: 361..379 score: 64.6 coord: 427..449 score: 65.01 coord: 323..336 score: 49.73 coord: 408..418 score: 66.01
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 250..502 e-value: 1.8E-89 score: 299.5
IPR020635	Tyrosine-protein kinase, catalytic domain	SMART	SM00219	tyrkin_6	coord: 249..504 e-value: 1.2E-123 score: 426.7
IPR036860	SH2 domain superfamily	GENE3D	G3DSA:3.30.505.10		coord: 126..240 e-value: 6.9E-24 score: 86.0
IPR036860	SH2 domain superfamily	SUPERFAMILY	SSF55550	SH2 domain	coord: 101..230
None	No IPR available	PIRSF	PIRSF000615	TyrPK_CSF1-R	coord: 337..516 e-value: 1.2E-48 score: 163.6 coord: 239..341 e-value: 3.0E-14 score: 49.8
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 242..508 e-value: 5.0E-88 score: 296.6
None	No IPR available	GENE3D	G3DSA:2.30.30.40		coord: 62..124 e-value: 1.2E-18 score: 68.3
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..21
None	No IPR available	PANTHER	PTHR24418:SF402	TYROSINE PROTEIN-KINASE SRC-1	coord: 64..515
None	No IPR available	PANTHER	PTHR24418	TYROSINE-PROTEIN KINASE	coord: 64..515
None	No IPR available	CDD	cd11845	SH3_Src_like	coord: 68..119 e-value: 4.70017E-21 score: 84.1712
IPR008266	Tyrosine-protein kinase, active site	PROSITE	PS00109	PROTEIN_KINASE_TYR	coord: 367..379
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 255..277
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 249..509 score: 43.566
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 236..511
IPR036028	SH3-like domain superfamily	SUPERFAMILY	SSF50044	SH3-domain	coord: 43..124