Beta-hexosaminidase

Overview


Name	Beta-hexosaminidase
Smed ID	SMED30026336
Length (bp)	2276

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Beta-hexosaminidase (SMED30026336) t-SNE clustered cells

Violin plots show distribution of expression levels for Beta-hexosaminidase (SMED30026336) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Beta-hexosaminidase (SMED30026336) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Beta-hexosaminidase (SMED30026336) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30026336

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30026336	h1SMcG0013034	SmedASXL_016059	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
pharynx	SMED30026336	h1SMcG0013034	dd_Smed_v4_12408_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30026336	h1SMcG0013034	dd_Smed_v4_12408_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30026336	h1SMcG0013034	dd_Smed_v4_12408_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30026336	h1SMcG0013034	dd_Smed_v4_12408_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30026336	h1SMcG0013034	dd_Smed_v6_12408_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXB (hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879])

HSP 1 Score: 314.309 bits (804), Expect = 1.871e-97
Identity = 167/479 (34.86%), Postives = 264/479 (55.11%), Query Frame = 1

Query:  466 NCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE-IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHK-LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWR--------SRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            +C L+  A  RY   IF      H             + ++F     ++++ +S+      +  P+ + DESY + + +   ++ +++ WG LRGLET +QL++      Y    I ++ I D+P++ HRG++IDTSRH++P+  +L+ L+ M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N ++ V+EYAR RGIRV+PE D PGHT SW K   +LLT C S  + K   +GP+NP L  TY FL   + E+  +FPD  +H+G DEV   CW ++P+I+DFM++     + + L   +I K L ++  +N   K  IVW+E  +    L   T++++W+        SRV        G P+I S  +YLD  +YG  W ++Y  +  ++         ++GGEAC+W E+     ++  +WP   A+ E LW  K  R+   A  +L   RCRM+  GI+ 
Sbjct:   90 SCTLLEEAFRRYHGYIFGFYKWHH-------------EPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY---QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYS-RQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATIN---KGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRV-----TASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAA 543

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXA (hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878])

HSP 1 Score: 295.049 bits (754), Expect = 2.070e-90
Identity = 171/509 (33.60%), Postives = 268/509 (52.65%), Query Frame = 1

Query:  385 WPKPQSISISNQ-FTPVSDNPAFK-----ILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVD-NFHH-----IKKGHPIIYSTSYYLDHATYGASWVQFYVND---FENYLNLN--YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            WP PQ+   S+Q +    +N  F+          C +++ A +RY+  +F   S        +  K ++ +K+  +       +S+    C   ++P+    E+Y + ++    L+ S   WG LRGLET +QL++   +  +    I   +I D P++ HRGL++DTSRH++P+S +L+ L+ M  NKLNVFHWH+ DD SFP++S + PEL  KG+++ +   Y+   +K V+EYAR RGIRV+ E D PGHT SW      LLT C S       F GP+NP L  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+DFM+K    E+ + L   +I  L  +++     K  +VW+E  +    +  +T+IQ+WR  +  N+        K G   + S  +YL+  +YG  W  FY+ +   FE         +GGEACMW E+     +   +WP   A+AE LW  K   +   A  +L   RC +LR G+  
Sbjct:   24 WPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPR---PYLTGKRHTLEKNVLV-------VSVVTPGC--NQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTF---FINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTF-GPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSY--GKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQA 514

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXA (hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878])

HSP 1 Score: 295.049 bits (754), Expect = 2.704e-90
Identity = 172/517 (33.27%), Postives = 269/517 (52.03%), Query Frame = 1

Query:  385 WPKPQSISISNQ-FTPVSDNPAFK-----ILDKNCELINLAIERYKKRIFSDKSIT--------HVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVD-NFHH-----IKKGHPIIYSTSYYLDHATYGASWVQFYVND---FENYLNLN--YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            WP PQ+   S+Q +    +N  F+          C +++ A +RY+  +F   S          H +      K ++ +K+  +       +S+    C   ++P+    E+Y + ++    L+ S   WG LRGLET +QL++   +  +    I   +I D P++ HRGL++DTSRH++P+S +L+ L+ M  NKLNVFHWH+ DD SFP++S + PEL  KG+++ +   Y+   +K V+EYAR RGIRV+ E D PGHT SW      LLT C S       F GP+NP L  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+DFM+K    E+ + L   +I  L  +++     K  +VW+E  +    +  +T+IQ+WR  +  N+        K G   + S  +YL+  +YG  W  FY+ +   FE         +GGEACMW E+     +   +WP   A+AE LW  K   +   A  +L   RC +LR G+  
Sbjct:   24 WPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGWPHQAYPVFLGKRHTLEKNVLV-------VSVVTPGC--NQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTF---FINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTF-GPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSY--GKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQA 525

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXA (hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878])

HSP 1 Score: 291.582 bits (745), Expect = 2.590e-89
Identity = 170/504 (33.73%), Postives = 266/504 (52.78%), Query Frame = 1

Query:  385 WPKPQSISISNQ-FTPVSDNPAFK-----ILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVD-NFHH-----IKKGHPIIYSTSYYLDHATYGASWVQFYVND---FENYLNLN--YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLR 1833
            WP PQ+   S+Q +    +N  F+          C +++ A +RY+  +F   S        +  K ++ +K+  +       +S+    C   ++P+    E+Y + ++    L+ S   WG LRGLET +QL++   +  +    I   +I D P++ HRGL++DTSRH++P+S +L+ L+ M  NKLNVFHWH+ DD SFP++S + PEL  KG+++ +   Y+   +K V+EYAR RGIRV+ E D PGHT SW      LLT C S       F GP+NP L  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+DFM+K    E+ + L   +I  L  +++     K  +VW+E  +    +  +T+IQ+WR  +  N+        K G   + S  +YL+  +YG  W  FY+ +   FE         +GGEACMW E+     +   +WP   A+AE LW  K   +   A  +L   RC +LR
Sbjct:   24 WPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPR---PYLTGKRHTLEKNVLV-------VSVVTPGC--NQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTF---FINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTF-GPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSY--GKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLR 509

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Human
Match: HEXB (hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879])

HSP 1 Score: 239.58 bits (610), Expect = 4.985e-72
Identity = 125/327 (38.23%), Postives = 184/327 (56.27%), Query Frame = 1

Query:  919 MEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHK-LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWR--------SRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N ++ V+EYAR RGIRV+PE D PGHT SW K   +LLT C S  + K   +GP+NP L  TY FL   + E+  +FPD  +H+G DEV   CW ++P+I+DFM++     + + L   +I K L ++  +N   K  IVW+E  +    L   T++++W+        SRV        G P+I S  +YLD  +YG  W ++Y  +  ++         ++GGEAC+W E+     ++  +WP   A+ E LW  K  R+   A  +L   RCRM+  GI+ 
Sbjct:    1 MAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYS-RQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATIN---KGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRV-----TASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAA 318

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BLAST of Beta-hexosaminidase vs. Ensembl Celegans
Match: hex-1 (Beta-hexosaminidase A [Source:UniProtKB/Swiss-Prot;Acc:Q22492])

HSP 1 Score: 234.958 bits (598), Expect = 3.907e-68
Identity = 170/542 (31.37%), Postives = 261/542 (48.15%), Query Frame = 1

Query:  370 SVGQPWPKPQSISISNQFTPVS-DNPAFKILDK-NCE-LINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPL-NPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGK---GCWATDPRIKDFMKKNQIENVELLLV-LFIHKL-QLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV--DNFHHIK----KGHPIIYSTSYYLDHATYGASW-----------VQFYVNDFENYLNLNYV-----GGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAAS---QLEEQRCRMLRNGISVGVGSGPSECLYLPDD 1893
            SVG  WP P+ I   ++   ++ D     + DK +C+ L+++A     K +F               ++ +     FI T T++      + C +G  P     E Y +R+S    +I++   WG LR +E+L+ L+F   D       I   +I D P++  RG+MID+SRHF+ ++ +   L  M MNKLNV HWH+ D +SFP+ S   PEL+  GA+     YS   I +V+ +AR RGIRVIPE D+PGHTSSW +     LTEC    +G + F   L +P+ E  + F+ +   E+   FPD  +H+G DEV      CW  + +I+ FM++    N  +LL   F  KL +++ NL   +K  I W+E  + NN    N VI IW+     + +  +K    +  P+I S  +YL++  YGA W            ++Y  D  N+           GG A +W E      I   +WP   A AE LW        A     ++ E RCR++  G  +   + P  C +  D+
Sbjct:   30 SVGGVWPLPKKIVYGSKNRTITYDKIGIDLGDKKDCDILLSMADNYMNKWLFP-----------FPVEMKTGGTEDFIITVTVK------DECPSGP-PVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFY--DHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSPRHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFD-EKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKRKP-IFWQEVFD-NNIPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQPNNNPDYCPFEFDE 547

[Close]

Query:  370 SVGQPWPKPQSISISNQFTPVS-DNPAFKILDK-NCE-LINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPL-NPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGK---GCWATDPRIKDFMKKNQIENVELLLV-LFIHKL-QLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV--DNFHHIK----KGHPIIYSTSYYLDHATYGASW-----------VQFYVNDFENYLNLNYV-----GGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAAS---QLEEQRCRMLRNGISVGVGSGPSECLYLPDD 1893
            SVG  WP P+ I   ++   ++ D     + DK +C+ L+++A     K +F               ++ +     FI T T++      + C +G  P     E Y +R+S    +I++   WG LR +E+L+ L+F   D       I   +I D P++  RG+MID+SRHF+ ++ +   L  M MNKLNV HWH+ D +SFP+ S   PEL+  GA+     YS   I +V+ +AR RGIRVIPE D+PGHTSSW +     LTEC    +G + F   L +P+ E  + F+ +   E+   FPD  +H+G DEV      CW  + +I+ FM++    N  +LL   F  KL +++ NL   +K  I W+E  + NN    N VI IW+     + +  +K    +  P+I S  +YL++  YGA W            ++Y  D  N+           GG A +W E      I   +WP   A AE LW        A     ++ E RCR++  G  +   + P  C +  D+
Sbjct:   30 SVGGVWPLPKKIVYGSKNRTITYDKIGIDLGDKKDCDILLSMADNYMNKWLFP-----------FPVEMKTGGTEDFIITVTVK------DECPSGP-PVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFY--DHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSPRHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFD-EKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKRKP-IFWQEVFD-NNIPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQPNNNPDYCPFEFDE 547

[Close]

Query:  370 SVGQPWPKPQSISISNQFTPVS-DNPAFKILDK-NCE-LINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPL-NPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGK---GCWATDPRIKDFMKKNQIENVELLLV-LFIHKL-QLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV--DNFHHIK----KGHPIIYSTSYYLDHATYGASW-----------VQFYVNDFENYLNLNYV-----GGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAAS---QLEEQRCRMLRNGISVGVGSGPSECLYLPDD 1893
            SVG  WP P+ I   ++   ++ D     + DK +C+ L+++A     K +F               ++ +     FI T T++      + C +G  P     E Y +R+S    +I++   WG LR +E+L+ L+F   D       I   +I D P++  RG+MID+SRHF+ ++ +   L  M MNKLNV HWH+ D +SFP+ S   PEL+  GA+     YS   I +V+ +AR RGIRVIPE D+PGHTSSW +     LTEC    +G + F   L +P+ E  + F+ +   E+   FPD  +H+G DEV      CW  + +I+ FM++    N  +LL   F  KL +++ NL   +K  I W+E  + NN    N VI IW+     + +  +K    +  P+I S  +YL++  YGA W            ++Y  D  N+           GG A +W E      I   +WP   A AE LW        A     ++ E RCR++  G  +   + P  C +  D+
Sbjct:   30 SVGGVWPLPKKIVYGSKNRTITYDKIGIDLGDKKDCDILLSMADNYMNKWLFP-----------FPVEMKTGGTEDFIITVTVK------DECPSGP-PVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFY--DHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSPRHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSW-RGRKGFLTECFD-EKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKRKP-IFWQEVFD-NNIPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQPNNNPDYCPFEFDE 547

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BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0300774)

HSP 1 Score: 189.119 bits (479), Expect = 4.047e-51
Identity = 139/450 (30.89%), Postives = 215/450 (47.78%), Query Frame = 1

Query:  664 NMDESYQIRL---SQGNIL--ISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTS-SWEKSNYELLTECKSLHRGK----KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKN--QIENVELLLVLFIHKLQLMINL----NFPKKTLIVWEEASEKNNNLT-----KNTVIQIWRSRVDNFHH--IKKGHPIIYST--SYYLDHA-----TYGASWVQFYV--------------NDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFG-KRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECL 1878
            + DESY + +   + G++L  I++   +G   GLETLAQL+ V  D         +A I+D P YK RGL++DTSR++  +  +   L GM + KLN FHWHI+D  SFP + K  PEL+  GA+     Y+   +  VVEY R RGIRV+PE D P H    W+  N   +T C +    K    +   G L+P + E Y  L+D+Y  +F  F     H+G DEV   CW +   I+ +MKK    +E  + + +    + + +  +    N     +I+W     +   +      +  +IQIW + VD      +++G+ II S   + YLD       T G +W   Y+               D+E+++    +G E  +W+E   + T+    WP   A+AE LW      +  A S+L   R R++ NG+       P  CL
Sbjct:  151 DTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLI-VYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQHKN---MTACFNAQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHV----LGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPAEGWRQAESRLLLHRQRLVDNGLGAEAMQ-PQWCL 591

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0333567)

HSP 1 Score: 189.119 bits (479), Expect = 4.047e-51
Identity = 139/450 (30.89%), Postives = 215/450 (47.78%), Query Frame = 1

Query:  664 NMDESYQIRL---SQGNIL--ISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTS-SWEKSNYELLTECKSLHRGK----KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKN--QIENVELLLVLFIHKLQLMINL----NFPKKTLIVWEEASEKNNNLT-----KNTVIQIWRSRVDNFHH--IKKGHPIIYST--SYYLDHA-----TYGASWVQFYV--------------NDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFG-KRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECL 1878
            + DESY + +   + G++L  I++   +G   GLETLAQL+ V  D         +A I+D P YK RGL++DTSR++  +  +   L GM + KLN FHWHI+D  SFP + K  PEL+  GA+     Y+   +  VVEY R RGIRV+PE D P H    W+  N   +T C +    K    +   G L+P + E Y  L+D+Y  +F  F     H+G DEV   CW +   I+ +MKK    +E  + + +    + + +  +    N     +I+W     +   +      +  +IQIW + VD      +++G+ II S   + YLD       T G +W   Y+               D+E+++    +G E  +W+E   + T+    WP   A+AE LW      +  A S+L   R R++ NG+       P  CL
Sbjct:  151 DTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLI-VYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQHKN---MTACFNAQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHV----LGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPAEGWRQAESRLLLHRQRLVDNGLGAEAMQ-PQWCL 591

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0073237)

HSP 1 Score: 189.119 bits (479), Expect = 4.047e-51
Identity = 139/450 (30.89%), Postives = 215/450 (47.78%), Query Frame = 1

Query:  664 NMDESYQIRL---SQGNIL--ISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTS-SWEKSNYELLTECKSLHRGK----KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKN--QIENVELLLVLFIHKLQLMINL----NFPKKTLIVWEEASEKNNNLT-----KNTVIQIWRSRVDNFHH--IKKGHPIIYST--SYYLDHA-----TYGASWVQFYV--------------NDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFG-KRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECL 1878
            + DESY + +   + G++L  I++   +G   GLETLAQL+ V  D         +A I+D P YK RGL++DTSR++  +  +   L GM + KLN FHWHI+D  SFP + K  PEL+  GA+     Y+   +  VVEY R RGIRV+PE D P H    W+  N   +T C +    K    +   G L+P + E Y  L+D+Y  +F  F     H+G DEV   CW +   I+ +MKK    +E  + + +    + + +  +    N     +I+W     +   +      +  +IQIW + VD      +++G+ II S   + YLD       T G +W   Y+               D+E+++    +G E  +W+E   + T+    WP   A+AE LW      +  A S+L   R R++ NG+       P  CL
Sbjct:  151 DTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLI-VYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQHKN---MTACFNAQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHV----LGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPAEGWRQAESRLLLHRQRLVDNGLGAEAMQ-PQWCL 591

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: Hexo1 (gene:FBgn0041630 transcript:FBtr0073235)

HSP 1 Score: 188.734 bits (478), Expect = 7.848e-51
Identity = 139/450 (30.89%), Postives = 215/450 (47.78%), Query Frame = 1

Query:  664 NMDESYQIRL---SQGNIL--ISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTS-SWEKSNYELLTECKSLHRGK----KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKN--QIENVELLLVLFIHKLQLMINL----NFPKKTLIVWEEASEKNNNLT-----KNTVIQIWRSRVDNFHH--IKKGHPIIYST--SYYLDHA-----TYGASWVQFYV--------------NDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFG-KRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECL 1878
            + DESY + +   + G++L  I++   +G   GLETLAQL+ V  D         +A I+D P YK RGL++DTSR++  +  +   L GM + KLN FHWHI+D  SFP + K  PEL+  GA+     Y+   +  VVEY R RGIRV+PE D P H    W+  N   +T C +    K    +   G L+P + E Y  L+D+Y  +F  F     H+G DEV   CW +   I+ +MKK    +E  + + +    + + +  +    N     +I+W     +   +      +  +IQIW + VD      +++G+ II S   + YLD       T G +W   Y+               D+E+++    +G E  +W+E   + T+    WP   A+AE LW      +  A S+L   R R++ NG+       P  CL
Sbjct:  151 DTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLI-VYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQHKN---MTACFNAQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHV----LGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNPAEGWRQAESRLLLHRQRLVDNGLGAEAMQ-PQWCL 591

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Fly
Match: fdl (gene:FBgn0045063 transcript:FBtr0346633)

HSP 1 Score: 181.8 bits (460), Expect = 3.019e-48
Identity = 139/456 (30.48%), Postives = 218/456 (47.81%), Query Frame = 1

Query:  517 SDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRL-SQGNIL---ISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTS-SWE---KSNYELLTECKSLHRGKKKFY------GPLNPILEETYLFLKDLYTELFL-LFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVL-FIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNT-VIQIWRSRV--DNFHHIKKGHPIIYS--TSYYLD------HATYGAS------WVQFYVNDFENYLNLN------YVGGEACMWNEFQSKETISQNIWPAMCAIAEILW 1767
            S KS  H  ++       +    K     T  ++ ISV    +     +N DE+YQ+   ++G+ L   I ++  +G   GL TL QL++   D D+      ++K+ D PK+++RGLM+DTSRHF  +  +   + GM + K+N FHWH++D QSFP+ S+ +PEL + GA+  + TYS   ++ V E+A+  G++VIPEID P H    W+   K     L  C  +++    FY      G LNP    TYL L+ +Y EL     P    H+G DEV   CWA       +     +  +    +L  + +L+L  N   PK  + VW  A      L  +   +Q+W      +N+  +  G+ +I+S   ++YLD       AT  A+      W   Y +     + L+       +GGE CMW E   +  +   +WP   A+AE LW
Sbjct:  166 SSKSRHHADLEPAATLFGATFGVKKAGDLTSVQVKISVLKSGDLNFSLDN-DETYQLSTQTEGHRLQVEIIANSYFGARHGLSTLQQLIWFD-DEDHLLHTYANSKVKDAPKFRYRGLMLDTSRHFFSVESIKRTIVGMGLAKMNRFHWHLTDAQSFPYISRYYPELAVHGAYSESETYSEQDVREVAEFAKIYGVQVIPEIDAPAHAGNGWDWGPKRGMGELAMC--INQQPWSFYCGEPPCGQLNPKNNYTYLILQRIYEELLQHTGPTDFFHLGGDEVNLDCWA------QYFNDTDLRGLWCDFMLQAMARLKLANNGVAPKH-VAVWSSALTNTKCLPNSQFTVQVWGGSTWQENYDLLDNGYNVIFSHVDAWYLDCGFGSWRATGDAACAPYRTWQNVYKHRPWERMRLDKKRKKQVLGGEVCMWTEQVDENQLDNRLWPRTAALAERLW 610

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexa (hexosaminidase A (alpha polypeptide) [Source:ZFIN;Acc:ZDB-GENE-050417-283])

HSP 1 Score: 316.235 bits (809), Expect = 1.102e-98
Identity = 178/516 (34.50%), Postives = 276/516 (53.49%), Query Frame = 1

Query:  385 WPKPQSISISNQ----------FTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKK--FYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKK----NQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRS---RVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFL---IAASQLEEQRCRMLRNGISV 1848
            WP PQ I  S +          FT   D+ A       C +++ A +RY   IF D      + D++++     K   F+       +S+SV+       P E+ DESY + +S+G  ++ S   WG LRGLE+ +QL++     DY    +   +I D P++  RGL++DTSRH++P+  +L+ L+ M  +K NVFHWHI DD SFP+QS++ P+L  KGAFH     Y+ + +  V+E+AR RGIRV+PE D PGHT SW K   +LLT C   ++G K    YGP++P ++ TY F++ L  E+  +FPD++VH+G DEV   CW ++P +  FM+K         +E   +  I  +   +N     KT IVW++  + +  + + TV++IW+    + +     K GH ++ S  +Y++H TYG  W   Y    +N+          +GGE  MW E+     ++  +WP  CA AE LW  +   L   +A  +LEE RC ++R GI  
Sbjct:   31 WPLPQEIQQSAESSGLSPQLFTFTYSQDSAA----QAGCSVLDTAFKRYFSIIFPD-----FTKDALHDMWLEPKA--FV-------LSVSVKTRGCDGYPDEDSDESYNLSVSEGQAVLRSVTVWGALRGLESFSQLVY---RDDYGAYFVNKTEIVDFPRFAFRGLLLDTSRHYLPLHAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSRTFPDLSKKGAFHPFTHIYTQSDVMRVIEHARMRGIRVVPEFDSPGHTQSWGKGQPDLLTPC---YKGSKPSGTYGPVDPTVDTTYRFMERLLKEVKFVFPDSYVHLGGDEVSFACWQSNPSVGKFMEKMGFGRDFTKLESFYMESIMNITAALN-----KTSIVWQDVFDYHERIPQGTVLEIWKGETYQTELSKMTKAGHRVLLSAPWYINHITYGQDWRNSYAVQPQNFSGTEEQKKLVIGGEVAMWGEYVDATNLNPRLWPRACAAAERLWSNEEKTLNADLAFPRLEEFRCELVRRGIQA 517

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 296.59 bits (758), Expect = 5.070e-91
Identity = 172/519 (33.14%), Postives = 270/519 (52.02%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKIL-------DKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR--VDNFHHIK-KGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISVGVGSGPSECLYL 1884
            WP PQ    S     +S   +F+I+         +C L+  A  RY + +F +             +    +K  F    +  ++ I+         PS   DESY + + + + ++ +   WG LRGLET +QL++   + DY    I    ISD P++ HRG+++D+SRHF+P+  +L NL  M MNK NVFHWHI DD SFPF S++ PEL  KGA+H     Y+ + +K V+E+AR RGIRV+ E D PGHT SW     +LLT C S       F   +NPIL  +Y F+  L+ E+  +FPD ++H+G DEV   CW ++P I+ FM +     +   L   +I +L  ++     KK  +VW+E  +    L  +TV+++W+     +   ++   G   I S  +YLD+ +YG  W ++Y  +  ++   +      +GGEAC+W E+     ++  +WP   A+AE LW       +  A ++L + RCRM+R GI       P+E L++
Sbjct:   38 WPLPQKYQSSAVAFKLS-AASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGE-----------LKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVY---EDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGP-VNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIVAAT--KKGYMVWQEVFDNGVKLKDDTVVEVWKGNDMKEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYYKVEPLDFTGTDAQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSDASVTDVGNAYTRLAQHRCRMVRRGI-------PAEPLFV 531

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexa (hexosaminidase A (alpha polypeptide) [Source:ZFIN;Acc:ZDB-GENE-050417-283])

HSP 1 Score: 295.819 bits (756), Expect = 7.939e-91
Identity = 174/515 (33.79%), Postives = 269/515 (52.23%), Query Frame = 1

Query:  385 WPKPQSISISNQ----------FTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKK--FYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKK----NQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR---VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFY------VNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFL---IAASQLEEQRCRMLRNGI 1842
            WP PQ I  S +          FT   D+ A       C +++ A +RY   IF D      + D++++     K   F+       +S+SV+       P E+ DESY + +S+G  ++ S   WG LRGLE+ +QL++     DY    +   +I D P++  RGL++DTSRH++P+  +L+ L+ M  +K NVFHWHI DD SFP+QS++ P+L  KGAFH     Y+ + +  V+E+AR RGIRV+PE D PGHT SW K   +LLT C   ++G K    YGP++P ++ TY F++ L  E+  +FPD++VH+G DEV   CW ++P +  FM+K         +E   +  I  +   +N     KT IVW++  + +       V+++W+      +     K G  +I +  +YLD      +W ++Y          E    L  +GGE  MW E+     ++  +WP  CA AE LW  +   L   +A  +LEE RC ++R GI
Sbjct:   31 WPLPQEIQQSAESSGLSPQLFTFTYSQDSAA----QAGCSVLDTAFKRYFSIIFPD-----FTKDALHDMWLEPKA--FV-------LSVSVKTRGCDGYPDEDSDESYNLSVSEGQAVLRSVTVWGALRGLESFSQLVY---RDDYGAYFVNKTEIVDFPRFAFRGLLLDTSRHYLPLHAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSRTFPDLSKKGAFHPFTHIYTQSDVMRVIEHARMRGIRVVPEFDSPGHTQSWGKGQPDLLTPC---YKGSKPSGTYGPVDPTVDTTYRFMERLLKEVKFVFPDSYVHLGGDEVSFACWYSNPSVGKFMEKMGFGRDFTKLESFYMESIMNITAALN-----KTSIVWQDVFDYHERPRSQYVVEVWKQGCYLCEMRRVTKAGLKVILAAPFYLDLPIPTQNWARYYGVRPLAFRGTEEQKKL-VIGGEVAMWGEYVDATNLNPRLWPRACAAAERLWSNEEKTLNADLAFPRLEEFRCELVRRGI 515

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 254.603 bits (649), Expect = 3.908e-76
Identity = 147/428 (34.35%), Postives = 227/428 (53.04%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKIL-------DKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR--VDNFHHIK-KGHPIIYSTSYYLDHATYGASWVQFY 1632
            WP PQ    S     +S   +F+I+         +C L+  A  RY + +F +             +    +K  F    +  ++ I+         PS   DESY + + + + ++ +   WG LRGLET +QL++   + DY    I    ISD P++ HRG+++D+SRHF+P+  +L NL  M MNK NVFHWHI DD SFPF S++ PEL  KGA+H     Y+ + +K V+E+AR RGIRV+ E D PGHT SW     +LLT C S        +GP+NPIL  +Y F+  L+ E+  +FPD ++H+G DEV   CW ++P I+ FM +     +   L   +I +L  ++     KK  +VW+E  +    L  +TV+++W+     +   ++   G   I S  +YLD+ +YG  W ++Y
Sbjct:   38 WPLPQKYQSSAVAFKLS-AASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGE-----------LKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVY---EDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGS-FGPVNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIVAAT--KKGYMVWQEVFDNGVKLKDDTVVEVWKGNDMKEELQNVTGAGFTTILSAPWYLDYISYGQDWQRYY 447

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BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 159.844 bits (403), Expect = 1.278e-43
Identity = 92/278 (33.09%), Postives = 141/278 (50.72%), Query Frame = 1

Query: 1087 GIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKK----GHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISVGVGSGPSECLYL 1884
            GIRV+ E D PGHT SW     +LLT C S       F   +NPIL  +Y F+  L+ E+  +FPD ++H+G DEV   CW ++P I+ FM +     +   L   +I +L  ++     KK  +VW+E  +    L  +T I +W+ R      + K    G   + ST +YL+  +YG  WV  Y  D +N+   +      +GGEAC+W E+     ++  +WP   A+AE LW       +  A ++L + RCRM+R GI       P+E L++
Sbjct:    2 GIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGP-VNPILNSSYEFMAQLFKEISTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFGTDYSKLESFYIQRLLDIVAAT--KKGYMVWQEVFDNGVKLKADTQIHVWKGRPQYQDEMAKVTAAGFSALLSTPWYLNRVSYGQDWVDIYKADPQNFNGTDAQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSDASVTDVGNAYTRLAQHRCRMVRRGI-------PAEPLFV 269

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BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770])

HSP 1 Score: 303.523 bits (776), Expect = 2.193e-93
Identity = 173/518 (33.40%), Postives = 277/518 (53.47%), Query Frame = 1

Query:  358 APTASVGQPWPKPQSISISNQ--FTPVSDNPAFKIL-------DKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGK-KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV---DNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
            A  +  G  WP PQ++ +S    + P S    F I+         +C L+  A  RY   +F               K  S K S   +   ++ + +S ++  +   P+   DESY++ + +   ++ ++Q WG LRGLET +QL++   +  +    I  + I D P++ HRG+++DTSRH++P+  +  NL+ M  NK NVFHWHI DD SFP+QS + P+L  KG++H     Y+   ++ V+EYAR RGIRV+PE D PGHT SW K    LLT C   ++G+    YGP+NPIL +TY F+   + E+  +FPD ++H+G DEV   CW ++P +  FM  +        L  + +  Q++  ++  KK  +VW+E  + N  L  +T+I++W+ ++   +       G   + S+ +YL+  +YG  W+Q Y  +  N+          +GGEACMW EF     ++  +WP   A+AE LW  +    +  A ++L + RCRMLR GI+ 
Sbjct:   44 AQDSPFGSLWPLPQTVILSADSFYIPPS---GFSIVHGSGSTAGTSCVLLQSAFRRYYDYMFGYSKW----------KRASAKPSNAGQLLQLQVVILSKDHQCH-RYPTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIY---EDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPC--FNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESY-YIQQVLGIVSSLKKGYMVWQEVFDNNVKLNPDTIIEVWKEQLYQEEMAAVTAAGFQALLSSPWYLNRISYGQDWIQVYKVEPANFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAA 541

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BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770])

HSP 1 Score: 302.368 bits (773), Expect = 6.207e-93
Identity = 173/519 (33.33%), Postives = 276/519 (53.18%), Query Frame = 1

Query:  358 APTASVGQPWPKPQSISISNQ--FTPVSDNPAFKIL-------DKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGK-KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR---VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFY------VNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
            A  +  G  WP PQ++ +S    + P S    F I+         +C L+  A  RY   +F               K  S K S   +   ++ + +S ++  +   P+   DESY++ + +   ++ ++Q WG LRGLET +QL++   +  +    I  + I D P++ HRG+++DTSRH++P+  +  NL+ M  NK NVFHWHI DD SFP+QS + P+L  KG++H     Y+   ++ V+EYAR RGIRV+PE D PGHT SW K    LLT C   ++G+    YGP+NPIL +TY F+   + E+  +FPD ++H+G DEV   CW ++P +  FM  +        L  + +  Q++  ++  KK  +VW+E  + N  +  +T++++W  +    + +     G P I +  +YLD+ +YG  W ++Y       N       L  +GGEACMW EF     ++  +WP   A+AE LW  +    +  A ++L + RCRMLR GI+ 
Sbjct:   44 AQDSPFGSLWPLPQTVILSADSFYIPPS---GFSIVHGSGSTAGTSCVLLQSAFRRYYDYMFGYSKW----------KRASAKPSNAGQLLQLQVVILSKDHQCH-RYPTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIY---EDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPC--FNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESY-YIQQVLGIVSSLKKGYMVWQEVFDNNVKINPDTIVEVWMGQNCYEELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYYKVEPLSFNGTAEQKQL-VIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAA 541

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770])

HSP 1 Score: 297.745 bits (761), Expect = 2.218e-92
Identity = 152/413 (36.80%), Postives = 238/413 (57.63%), Query Frame = 1

Query:  655 PSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGK-KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR---VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN--------YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
            P+   DESY++ + +   ++ ++Q WG LRGLET +QL++   +  +    I  + I D P++ HRG+++DTSRH++P+  +  NL+ M  NK NVFHWHI DD SFP+QS + P+L  KG++H     Y+   ++ V+EYAR RGIRV+PE D PGHT SW K    LLT C   ++G+    YGP+NPIL +TY F+   + E+  +FPD ++H+G DEV   CW ++P +  FM  +        L  + +  Q++  ++  KK  +VW+E  + N  +  +T++++W  +    + +     G P I +  +YLD+ +YG  W ++Y    E   N N         +GGEACMW EF     ++  +WP   A+AE LW  +    +  A ++L + RCRMLR GI+ 
Sbjct:   38 PTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIY---EDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPC--FNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESY-YIQQVLGIVSSLKKGYMVWQEVFDNNVKINPDTIVEVWMGQNCYEELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYY--KVEPLTNFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAA 442

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770])

HSP 1 Score: 286.189 bits (731), Expect = 4.227e-88
Identity = 150/410 (36.59%), Postives = 233/410 (56.83%), Query Frame = 1

Query:  655 PSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGK-KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV---DNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
            P+   DESY++ + +   ++ ++Q WG LRGLET +QL++   +  +    I  + I D P++ HRG+++DTSRH++P+  +  NL+ M  NK NVFHWHI DD SFP+QS + P+L  KG++H     Y+   ++ V+EYAR RGIRV+PE D PGHT SW K    LLT C   ++G+    YGP+NPIL +TY F+   + E+  +FPD ++H+G DEV   CW        ++   Q    +L        L ++ +L   KK  +VW+E  + N  L  +T+I++W+ ++   +       G   + S+ +YL+  +YG  W+Q Y  +  N+          +GGEACMW EF     ++  +WP   A+AE LW  +    +  A ++L + RCRMLR GI+ 
Sbjct:   38 PTVQSDESYELSVGENVAVLKANQVWGALRGLETFSQLIY---EDRFGAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPC--FNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCW--------YVANVQWTKHKLNFTFMSLFLGIVSSL---KKGYMVWQEVFDNNVKLNPDTIIEVWKEQLYQEEMAAVTAAGFQALLSSPWYLNRISYGQDWIQVYKVEPANFNGTAEQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAA 431

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Match: hexb (hexosaminidase B (beta polypeptide) [Source:NCBI gene;Acc:100145770])

HSP 1 Score: 286.189 bits (731), Expect = 3.508e-87
Identity = 168/519 (32.37%), Postives = 269/519 (51.83%), Query Frame = 1

Query:  358 APTASVGQPWPKPQSISISNQ--FTPVSDNPAFKIL-------DKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGK-KKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR---VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFY------VNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
            A  +  G  WP PQ++ +S    + P S    F I+         +C L+  A  RY   +F               K  S K S   +   ++ + +S ++  +   P+   DESY++ + +   ++ ++Q WG LRG   +     +     +    I  + I D P++ HRG+++DTSRH++P+  +  NL+ M  NK NVFHWHI DD SFP+QS + P+L  KG++H     Y+   ++ V+EYAR RGIRV+PE D PGHT SW K    LLT C   ++G+    YGP+NPIL +TY F+   + E+  +FPD ++H+G DEV   CW ++P +  FM  +        L  + +  Q++  ++  KK  +VW+E  + N  +  +T++++W  +    + +     G P I +  +YLD+ +YG  W ++Y       N       L  +GGEACMW EF     ++  +WP   A+AE LW  +    +  A ++L + RCRMLR GI+ 
Sbjct:   19 AQDSPFGSLWPLPQTVILSADSFYIPPS---GFSIVHGSGSTAGTSCVLLQSAFRRYYDYMFGYSKW----------KRASAKPSNAGQLLQLQVVILSKDHQCH-RYPTVQSDESYELSVGENVAVLKANQVWGALRGYFFIPPKFILCSVKQF---LINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPC--FNKGQLSGAYGPVNPILNDTYNFMYTFFQEISNVFPDQYIHLGGDEVDFSCWKSNPDVTKFMTDHGFGTDYCKLESY-YIQQVLGIVSSLKKGYMVWQEVFDNNVKINPDTIVEVWMGQNCYEELYKVTAAGFPAIMAAPWYLDYISYGQDWQKYYKVEPLSFNGTAEQKQL-VIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCRMLRRGIAA 516

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Mouse
Match: Hexb (hexosaminidase B [Source:MGI Symbol;Acc:MGI:96074])

HSP 1 Score: 316.235 bits (809), Expect = 1.211e-98
Identity = 173/507 (34.12%), Postives = 270/507 (53.25%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVS------DNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE-IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHK-LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNF---HHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            WP P+S+ +  +   +S      D+        +C L+  A  RY   +F      H               ++F     ++K+ +S+      E  PS + DE+Y + + +   ++ ++  WG LRGLET +QL++      +    I ++ I+D+P++ HRG++IDTSRHF+P+  +L+ L+ M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N ++ V+EYAR RGIRVIPE D PGHT SW K    LLT C +  + K + +GP++P +  TY F    + E+  +FPD  +H+G DEV   CWA++P I+ FMK+     +   L   +I K L+++ +L   KK  IVW+E  +    L   TV+++W+S   ++        G P I S  +YLD  +YG  W  +Y  +  N+          +GGEAC+W EF     ++  +WP   A+ E LW  K   +   A  +L   RCRM+  GI+ 
Sbjct:   36 WPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHH-------------GPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVY---QDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYN-QKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSL---KKNSIVWQEVFDDKVELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAA 522

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Mouse
Match: Hexa (hexosaminidase A [Source:MGI Symbol;Acc:MGI:96073])

HSP 1 Score: 289.271 bits (739), Expect = 1.779e-88
Identity = 169/508 (33.27%), Postives = 259/508 (50.98%), Query Frame = 1

Query:  385 WPKPQSI-SISNQFTPVSDNPAFK-----ILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHI------KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFG--KRNFLIAASQLEEQRCRMLRNGISV 1848
            WP PQ I +   ++T   +N  F+          C +++ A  RY+  +F   S    S     NK  +  K+  +       +S+    C   E P+    E+Y + ++    L++S   WG LRGLET +QL++   +  +    I   KI D P++ HRG+++DTSRH++P+S +L+ L+ M  NK NVFHWH+ DD SFP++S + PEL  KG+F+ +   Y+   +K V+EYAR RGIRV+ E D PGHT SW      LLT C S       F GP+NP L  TY F+  L+ E+  +FPD ++H+G DEV   CW ++P I+ FMKK    + + L   +I  L  +++     K  +VW+E  +    +  +T+IQ+WR  +   + +      + G   + S  +YL+   YG  W   Y  +   +          +GGEACMW E+     +   +WP   A+AE LW      N   A  +L   RC ++R GI  
Sbjct:   24 WPWPQYIQTYHRRYTLYPNNFQFRYHVSSAAQAGCVVLDEAFRRYRNLLFGSGSWPRPSFS---NKQQTLGKNILV-------VSVVTAEC--NEFPNLESVENYTLTINDDQCLLASETVWGALRGLETFSQLVWKSAEGTF---FINKTKIKDFPRFPHRGVLLDTSRHYLPLSSILDTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGAPGLLTPCYSGSHLSGTF-GPVNPSLNSTYDFMSTLFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDFKQLESFYIQTLLDIVSDY--DKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVEYMLEMQDITRAGFRALLSAPWYLNRVKYGPDWKDMYKVEPLAFHGTPEQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAVAERLWSSNLTTNIDFAFKRLSHFRCELVRRGIQA 513

[Close]

BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|P49614|HEXB_FELCA (Beta-hexosaminidase subunit beta OS=Felis catus OX=9685 GN=HEXB PE=2 SV=2)

HSP 1 Score: 321.242 bits (822), Expect = 9.452e-100
Identity = 180/516 (34.88%), Postives = 276/516 (53.49%), Query Frame = 1

Query:  364 TASVGQP-WPKPQSISISNQFTPVS-DNPAF-----KILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE---IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV--DNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
            +A+ G   WP P S+  S +   +S DN +            C L+  A  RY + IF                 +  ++        IE   + V    + E    P+   DESY + + +    + +++ WG+LRGLET +QL++      Y    + ++ I D+P++ HRG++IDT+RHF+P+  +L+ L+ M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N +  V+EYAR RGIRVIPE D PGHT SW K   +LLT C + H+    F GP+NPIL  TY FL   + E+ ++FPD  VH+G DEV   CW ++P I+ FMK+    ++   L   ++ KL  +++    KK  IVW+E  + +  L   T++Q+W+++V  +    +   G P+I S  +YLD  +YG  W  +Y  D  ++          +GGEAC+W EF     ++  +WP   A+ E LW  +    +  A ++L   RCRM+R GIS 
Sbjct:   23 SAAAGAALWPMPLSVKTSPRLLHLSRDNFSIGYGPSSTAGPTCSLLQEAFRRYHEYIFG---------------FDKRQRRPAKPNSAIELQQLLVTVVLDSECDLFPNITSDESYTLLVKEPVAFLKANRVWGVLRGLETFSQLIY---QDSYGTFTVNESDIIDSPRFPHRGILIDTARHFLPVKSILKTLDAMAFNKFNVLHWHIVDDQSFPYQSVTFPELSNKGSYSLSHVYTPNDVHTVIEYARLRGIRVIPEFDSPGHTQSWGKGQKDLLTPCYNEHKQSGTF-GPINPILNSTYNFLSQFFKEVSMVFPDHFVHLGGDEVEFQCWESNPEIQGFMKQKGFGKDFRRLESFYLQKLLGIVSTV--KKGSIVWQEVFDDHVKLLPGTIVQVWKNQVYTEELREVTAAGFPVILSAPWYLDWISYGQDWRNYYKVDPLHFDGSQEQKKLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPEDITSVGNAYNRLTVHRCRMVRRGISA 517

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BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|P20060|HEXB_MOUSE (Beta-hexosaminidase subunit beta OS=Mus musculus OX=10090 GN=Hexb PE=1 SV=2)

HSP 1 Score: 316.235 bits (809), Expect = 8.470e-98
Identity = 173/507 (34.12%), Postives = 270/507 (53.25%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVS------DNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE-IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHK-LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNF---HHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            WP P+S+ +  +   +S      D+        +C L+  A  RY   +F      H               ++F     ++K+ +S+      E  PS + DE+Y + + +   ++ ++  WG LRGLET +QL++      +    I ++ I+D+P++ HRG++IDTSRHF+P+  +L+ L+ M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N ++ V+EYAR RGIRVIPE D PGHT SW K    LLT C +  + K + +GP++P +  TY F    + E+  +FPD  +H+G DEV   CWA++P I+ FMK+     +   L   +I K L+++ +L   KK  IVW+E  +    L   TV+++W+S   ++        G P I S  +YLD  +YG  W  +Y  +  N+          +GGEAC+W EF     ++  +WP   A+ E LW  K   +   A  +L   RCRM+  GI+ 
Sbjct:   36 WPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHH-------------GPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVY---QDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYN-QKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSL---KKNSIVWQEVFDDKVELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAA 522

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BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|P07686|HEXB_HUMAN (Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=3)

HSP 1 Score: 315.464 bits (807), Expect = 3.479e-97
Identity = 177/527 (33.59%), Postives = 281/527 (53.32%), Query Frame = 1

Query:  355 HAPTASVGQPWPKPQSISISNQFTP-----------VSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE-IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHK-LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWR--------SRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
             AP+ S  +P P    + +S + TP           +S +P       +C L+  A  RY   IF      H             + ++F     ++++ +S+      +  P+ + DESY + + +   ++ +++ WG LRGLET +QL++      Y    I ++ I D+P++ HRG++IDTSRH++P+  +L+ L+ M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N ++ V+EYAR RGIRV+PE D PGHT SW K   +LLT C S  + K   +GP+NP L  TY FL   + E+  +FPD  +H+G DEV   CW ++P+I+DFM++     + + L   +I K L ++  +N   K  IVW+E  +    L   T++++W+        SRV        G P+I S  +YLD  +YG  W ++Y  +  ++         ++GGEAC+W E+     ++  +WP   A+ E LW  K  R+   A  +L   RCRM+  GI+ 
Sbjct:   44 RAPSVS-AKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPN-STAGPSCTLLEEAFRRYHGYIFGFYKWHH-------------EPAEFQAKTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY---QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYS-RQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATIN---KGSIVWQEVFDDKAKLAPGTIVEVWKDSAYPEELSRV-----TASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAA 543

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BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|Q6AXR4|HEXB_RAT (Beta-hexosaminidase subunit beta OS=Rattus norvegicus OX=10116 GN=Hexb PE=2 SV=1)

HSP 1 Score: 314.309 bits (804), Expect = 5.467e-97
Identity = 178/509 (34.97%), Postives = 270/509 (53.05%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVS------DNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEY---CFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHK-LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR--VDNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            WP P+S+ +  +   +S      DN        +C L+  A  RY   IF      H               +KF +   +EK+ + +     C     PS + DESY + + +   L+ +++ WG LRGLET +QL++      Y    I ++ I+D+P++ HRG++IDTSRH++P+  + + L+ M  NK NV HWHI DDQSFP+QS + PEL  KG++ ++  Y+ N I  V+EYAR RGIRVIPE D PGHT SW K    LLT C  + + + +  GP++P L  TY+F    + E+  +FPD  +H+G DEV   CWA++P I++FMKK     N   L   +I K L ++ +L   KK+ IVW++  +    L   TV+++W+S   ++    +   G P I S  +YLD  +YG  W  +Y  +  N+          +GGEAC+W E+     +   +WP   A+ E LW  +   N   A  +L   RCRM+  GI+ 
Sbjct:   35 WPMPRSVQVFPRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHH-------------GPAKFQDKPQLEKLLVFINLEPQC--DAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVY---QDAYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSWGKGQKNLLTPC-FIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEVEFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSL---KKSSIVWQDVFDDQVELQPGTVVEVWKSENYLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFEGSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLAVHRCRMVSRGIAA 521

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BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Match: sp|Q29548|HEXB_PIG (Beta-hexosaminidase subunit beta OS=Sus scrofa OX=9823 GN=HEXB PE=1 SV=2)

HSP 1 Score: 303.523 bits (776), Expect = 6.836e-93
Identity = 179/529 (33.84%), Postives = 275/529 (51.98%), Query Frame = 1

Query:  307 ERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTEC--KSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVEL---LLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHH---IKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISV 1848
            ER+A++ S      +W  P A        P+S+ +S        +P  K    +CE++  A  RY   IF        S    +                ++++ + VE   +   PS + +ESY + +     L+ ++  WG LRGLET +QL++      Y    + +++I D P++ HRG++IDT RHF+ +  + + L+ M  NK NV HWHI DDQSFP+QS +   L  KG++ ++  Y+ N ++ V+EYAR RGIRV+PE D PGH+ SW K   +LLT C  K +  G    +GP+NPIL  TY FL   + E+  +FPD  +HIG DEV   CWA++  I  FM++     + L   L  +F  K+  MI+    KK  IVW+EA +  +     TV+Q+W+     +      K G P+I S  +YLD  +YG  W  +Y  + +++   +      +GGEAC+W E+     ++  +WP   A+ E LW  K  R+   A S+L   RCRM+R GI+ 
Sbjct:   18 ERWARDTSGAESLGLWPLPFAVD----ISPRSLHLSPNNFFFGHSPTSKA-GSSCEILQEAFRRYYDFIFGFYKWHQGSYQLCFG-------------TELQQLQVHVESECD-TFPSISSNESYVLHVKGPEALLRANTVWGALRGLETFSQLIY---QDSYGTFTVNESEIIDFPRFPHRGILIDTGRHFLSVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSINFGVLSSKGSYSLSHVYTPNDVRMVIEYARIRGIRVMPEFDTPGHSRSWGKGQKDLLTPCYRKQVLSGT---FGPINPILNTTYNFLSKFFKEISTVFPDEFIHIGGDEVDFDCWASNSEILQFMQEKGFSQISLNSNLCTVF--KISNMISAM--KKRPIVWQEAFDGRDKFMPGTVVQVWKIEDYKWEQSLITKAGFPVILSAPWYLDLISYGQDWKNYYEVEPQDFPGSDKERKRVLGGEACLWGEYVDATNLTPRLWPRASAVGERLWSHKDVRDIHDAYSRLTIHRCRMVRRGIAA 517

[Close]

BLAST of Beta-hexosaminidase vs. TrEMBL
Match: A0A267DHF5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig005042g2 PE=4 SV=1)

HSP 1 Score: 380.178 bits (975), Expect = 3.675e-116
Identity = 211/600 (35.17%), Postives = 309/600 (51.50%), Query Frame = 1

Query:  313 FAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDK------------NC-----ELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE-------IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMIN------LNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVND-FENYLN--------------------------------LNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWF---GKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFN 1911
            FA    P  E+H+W AP  SVG+ WP+P     S     ++      +  K            +C     EL+ +A +RY++ I   ++++  +  +     +            I ++S+ +    + E       +PS +MDESY +++S+   ++S+ + WG+LRGL+T +QL++   D+    L I    I D P++KHRGL++DTSRH++ +  L  NL+ MEMNKLNVFHWHI DDQSFP+QS   P+L  KGA+  N  YS + I+ ++EYAR RGIRVIPE D P HT SW     E+ T+C +       FYGP+NP L  T+ FLK LY E+  +F D ++H+G DEVG  CW  +P +            + L+  +  +LQ +I        N  K+  IVW+EA +    L + T++Q+W+    +   + + G+ ++YST +YLD   YG  W + Y+ D   NY                                   N +GGEACMWNE+Q   T+ Q IWP   A+AE LW      R+ L A  ++EEQRCRM   GI VGV SGP  C   P   + S N
Sbjct:   83 FALLDPPDTEFHVWRAPFPSVGEAWPRPTRQYASRSRGRITAPEHLSLAAKEFQFVLTSPTESDCPIAVVELLKMAFQRYRRVIVDQRAVSVAAGAAADADGH------------IRQLSVRLTIQSSDEKWRTAPLMPSLDMDESYTLKISKTEAVLSAPEPWGVLRGLQTFSQLVWQTQDAA---LYINSTTIFDKPRFKHRGLLVDTSRHYLSMETLKTNLDAMEMNKLNVFHWHIVDDQSFPYQSVVFPKLSEKGAYDSNSIYSLSNIREIIEYARVRGIRVIPEFDTPAHTHSWSLGYPEIFTQCFNYANRWTGFYGPMNPALNATFDFLKKLYAEISSVFKDNYIHLGADEVGTSCWDNNPIVNRMRADFGFSRSDQLIDYYFRRLQNIITSLSAGKSNSNKRGFIVWQEAYDHGVMLKRGTIVQVWKGEASDVAMVAQAGYRVLYSTCWYLDRLEYGPQWTKMYLCDPIANYAGTYNGGPFQQQMPQQQPPPQQQQQQQPPPPSWMANVLGGEACMWNEYQDDNTVLQRIWPLASAVAERLWSSPEATRDLLAAGRRIEEQRCRMRARGIPVGVASGPGSCRPPPPAGNRSRN 667

[Close]

BLAST of Beta-hexosaminidase vs. TrEMBL
Match: A0A267E9J5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006253g2 PE=4 SV=1)

HSP 1 Score: 379.407 bits (973), Expect = 7.765e-116
Identity = 211/600 (35.17%), Postives = 311/600 (51.83%), Query Frame = 1

Query:  313 FAKEKSPVHEYHIWHAPTASVGQPWPKPQS---------ISISNQFTPVSDNPAFKIL---DKNC-----ELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGE-------IPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMIN------LNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVND-FENYLN--------------------------------LNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWF---GKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFN 1911
            FA    P  E+H+W AP  S+G+ WP+P           I+   Q +  +    F +    + +C     EL+ +A +RY++ I   ++++  +  +     +            I ++S+ +    + E       +PS +MDESY +++S+    +S+ + WG+LRGL+T +QL++   D+    L I    I D P++KHRGL++DTSRH++ +  L  NL+ MEMNKLNVFHWHI DDQSFP+QS   P+L  KGA+  N  YS + I+ ++EYAR RGIRVIPE D P HT SW     E+ T+C +       FYGP+NP L  T+ FLK LY E+  +F D ++H+G DEVG  CW  +P +            + L+  +  +LQ +I        N  K+  IVW+EA +    L + T++Q+W+    +   + + G+ ++YST +YLD   YG  W + Y+ D   NY                                   N +GGEACMWNE+Q   T+ Q IWP   A+AE LW      R+ L A  ++EEQRCRM   GI VGV SGP  C   P   + S N
Sbjct:   83 FALLDPPDTEFHVWRAPFPSLGEAWPRPTRQYTSRSRGRITAPEQLSLAAKEFQFVLTSPTESDCPIAVVELLKMAFQRYRRVIVDQRAVSVAAGAAADADGH------------IRQLSVRLTIQSSDEKWRTAPLMPSLDMDESYTLKISKTEAQLSAPEPWGVLRGLQTFSQLVWQTQDAA---LYINSTTIFDKPRFKHRGLLVDTSRHYLSMETLKTNLDAMEMNKLNVFHWHIVDDQSFPYQSVVFPKLSEKGAYDSNSIYSLSNIREIIEYARVRGIRVIPEFDTPAHTHSWSLGYPEIFTQCFNYANRWTGFYGPMNPALNATFDFLKKLYAEISSVFKDNYIHLGADEVGTSCWDNNPIVNRMRADFGFSRSDQLIDYYFRRLQNIITSLSAGKSNSNKRGFIVWQEAYDHGVMLKRGTIVQVWKGEASDVAMVAQAGYRVLYSTCWYLDRLEYGPQWTKMYLCDPIANYAGTYNGGPFQQQMPQQQPPPQQQQQQQPPPPSWMANVLGGEACMWNEYQDDNTVLQRIWPLASAVAERLWSSPEATRDLLAAGRRIEEQRCRMRARGIPVGVASGPGSCRPPPPAGNRSRN 667

[Close]

BLAST of Beta-hexosaminidase vs. TrEMBL
Match: A0A267E3Z4 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013942g3 PE=4 SV=1)

HSP 1 Score: 378.637 bits (971), Expect = 1.477e-115
Identity = 211/593 (35.58%), Postives = 313/593 (52.78%), Query Frame = 1

Query:  313 FAKEKSPVHEYHIWHAPTASVGQPWPKPQS---------ISISNQFTPVSDNPAFKIL---DKNC-----ELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMIN------LNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVND-FENYLN--------------------------------LNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWF---GKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFN 1911
            FA    P  E+H+W AP  S+G+ WP+P           I+   Q +  +    F +    + +C     EL+ +A +RY++ I   ++++  +  +     +  + S  +   TI+  S   ++     +PS +MDESY +++S+   ++S+ + WG+LRGL+T +QL++   D+    L +    I D P++KHRGL++DTSRH++ +  L  NL+ MEMNKLNVFHWHI DDQSFP+QS   P+L  KGA+  N  YS + I+ ++EYAR RGIRVIPE D P HT SW     E+ T+C +       FYGP+NP L  T+ FLK LY E+  +F D ++H+G DEVG  CW  +P +            + L+  +  +LQ +I        N  K+  IVW+EA +    L + T++Q+W+    +   + + G+ ++YST +YLD   YG  W + Y+ D   NY                                   N +GGEACMWNE+Q   T+ Q IWP   A+AE LW      R+ L A  ++EEQRCRM   GI VGV SGP  C   P   + S N
Sbjct:   83 FALLDPPDTEFHVWRAPFPSLGEAWPRPTRQYTSRSRGRITAPEQLSLAAKEFQFVLTSPTESDCPIAVVELLKMAFQRYRRVIVDQRAVSVAAGAAADADGHIWQLSVRL---TIQ--SSDEKWRTAPLMPSLDMDESYTLKISKTEAVLSAPEPWGVLRGLQTFSQLVWQTQDAA---LYVNSTTIFDKPRFKHRGLLVDTSRHYLSMETLKTNLDAMEMNKLNVFHWHIVDDQSFPYQSVVFPKLSEKGAYDSNSIYSLSNIREIIEYARVRGIRVIPEFDTPAHTHSWSLGYPEIFTQCFNYANRWTGFYGPMNPALNATFDFLKKLYAEISSVFKDNYIHLGADEVGTSCWDNNPIVNRMRADFGFSRSDQLIDYYFRRLQNIITSLSAGKSNSNKRGFIVWQEAYDHGVMLKRGTIVQVWKGEASDVAMVAQAGYRVLYSTCWYLDRLEYGPQWTKMYLCDPIANYAGTYNGGPFQQQMPQQQPPPQQQQQQQPPPPSWMANVLGGEACMWNEYQDDNTVLQRIWPLASAVAERLWSSPEATRDLLAAGRRIEEQRCRMRARGIPVGVASGPGSCRPPPPAGNRSRN 667

[Close]

BLAST of Beta-hexosaminidase vs. TrEMBL
Match: Q7Q0Z2 (Beta-hexosaminidase OS=Anopheles gambiae OX=7165 GN=AgaP_AGAP010056 PE=3 SV=4)

HSP 1 Score: 364.385 bits (934), Expect = 1.553e-113
Identity = 202/526 (38.40%), Postives = 304/526 (57.79%), Query Frame = 1

Query:  367 ASVGQPWPKPQSISISNQFTPVSDNP-AFKILDKNCELINLAIERYKKRIFSDKSITHVSVD------------SIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRS-RVDNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILW--FGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECL 1878
            A+ G+ WPKP++ + S Q+  +     AF+ ++ +C+L+  A+ERY+K + S  + T  ++             S  +  N   +S       +E++ + ++     E+P  +MDE Y I +      +SS   WG+LR LE+ +Q+  VV+  D + L I    I D P++ HRGL++DTSRHFI    L++ L+GM  NKLNVFHWHI DD SFP++SK+ PEL  KGA+H +M Y+   I+ ++E AR RGIRV+ E D PGHT SW  S+ ELLTEC+  +RGK    GP++P  E TY FL +L+ E+  +FPD +VH+G DEVG  CWA++P I ++MK+N++ + E+L   FI ++   I++    ++ +VW+E       L K TV+ +W   R D  + I + G P + S+ +YLDH + G  W +FY  D  +++         +GGEACMW+E  +   I   I+P + A AE LW      N   AA +LEEQ CRM   GI     +GP  C+
Sbjct:   37 ATKGEIWPKPRNQTTSQQYYTIKTGSFAFQSMNYSCDLLEKALERYQKLVLSIGNTTRRAMHNRGYAFQSRNELSSASHANRSWRSDTNWAGYLEQVQVDLKAPCE-ELPHLSMDEEYTINIDDFQARLSSFSIWGMLRALESFSQM--VVLSDDGSMLRINSTTIDDGPRFSHRGLLVDTSRHFIDTCTLVKILDGMAYNKLNVFHWHIVDDHSFPYESKAFPELSEKGAYHPSMVYTQRDIQMIIEEARLRGIRVMSEFDTPGHTRSWGVSHPELLTECQDQYRGK---LGPMDPTRESTYTFLSNLFREVIEVFPDQYVHLGGDEVGFECWASNPNILEYMKQNRLYSFEMLEEKFIQRIVDQIDV--LNRSSLVWQEVYVNGVRLPKGTVVHVWTGNRQDLLNKITRDGLPALLSSCWYLDHLSTGGDWRKFYNCDPHDFIGTGQQKSLVLGGEACMWSEVVNGHNILPRIFPRVSATAEKLWSPASVNNADEAARRLEEQTCRMNHRGIPAQPPNGPGFCI 554

[Close]

BLAST of Beta-hexosaminidase vs. TrEMBL
Match: A0A1S4H3Q6 (Beta-hexosaminidase OS=Anopheles gambiae OX=7165 PE=3 SV=1)

HSP 1 Score: 365.155 bits (936), Expect = 3.327e-113
Identity = 202/526 (38.40%), Postives = 304/526 (57.79%), Query Frame = 1

Query:  367 ASVGQPWPKPQSISISNQFTPVSDNP-AFKILDKNCELINLAIERYKKRIFSDKSITHVSVD------------SIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRS-RVDNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILW--FGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECL 1878
            A+ G+ WPKP++ + S Q+  +     AF+ ++ +C+L+  A+ERY+K + S  + T  ++             S  +  N   +S       +E++ + ++     E+P  +MDE Y I +      +SS   WG+LR LE+ +Q+  VV+  D + L I    I D P++ HRGL++DTSRHFI    L++ L+GM  NKLNVFHWHI DD SFP++SK+ PEL  KGA+H +M Y+   I+ ++E AR RGIRV+ E D PGHT SW  S+ ELLTEC+  +RGK    GP++P  E TY FL +L+ E+  +FPD +VH+G DEVG  CWA++P I ++MK+N++ + E+L   FI ++   I++    ++ +VW+E       L K TV+ +W   R D  + I + G P + S+ +YLDH + G  W +FY  D  +++         +GGEACMW+E  +   I   I+P + A AE LW      N   AA +LEEQ CRM   GI     +GP  C+
Sbjct:   82 ATKGEIWPKPRNQTTSQQYYTIKTGSFAFQSMNYSCDLLEKALERYQKLVLSIGNTTRRAMHNRGYAFQSRNELSSASHANRSWRSDTNWAGYLEQVQVDLKAPCE-ELPHLSMDEEYTINIDDFQARLSSFSIWGMLRALESFSQM--VVLSDDGSMLRINSTTIDDGPRFSHRGLLVDTSRHFIDTCTLVKILDGMAYNKLNVFHWHIVDDHSFPYESKAFPELSEKGAYHPSMVYTQRDIQMIIEEARLRGIRVMSEFDTPGHTRSWGVSHPELLTECQDQYRGK---LGPMDPTRESTYTFLSNLFREVIEVFPDQYVHLGGDEVGFECWASNPNILEYMKQNRLYSFEMLEEKFIQRIVDQIDV--LNRSSLVWQEVYVNGVRLPKGTVVHVWTGNRQDLLNKITRDGLPALLSSCWYLDHLSTGGDWRKFYNCDPHDFIGTGQQKSLVLGGEACMWSEVVNGHNILPRIFPRVSATAEKLWSPASVNNADEAARRLEEQTCRMNHRGIPAQPPNGPGFCI 599

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexa (beta-hexosaminidase subunit alpha-like [Source:NCBI gene;Acc:103046771])

HSP 1 Score: 311.227 bits (796), Expect = 9.571e-97
Identity = 181/525 (34.48%), Postives = 273/525 (52.00%), Query Frame = 1

Query:  349 IWHAPTASVGQPWPKPQSISISNQ---FTPVSDNPAFK---ILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQ--IKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKK----NQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRS-----RVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKR---NFLIAASQLEEQRCRMLRNGISV 1848
            I H     V   WP PQ I+ S      +P S + ++         C +++ A +RY   IF D +             +  + S      T   +S+SV+       P E  DESY + ++ G   + +   WG LRGLE+ +QL++      YN   +   +I D P+++ RGL++DTSRH++P++ +L+ L+ M  +K NVFHWHI DD SFP+QS S+P+L  KGAFH  MT+ Y Q  +K V+ +AR RGIRVIPE D PGHT SW K    LLT C         F GP+NPIL+ TY F+  L+ E+  +FPD++VH+G DEV   CW ++P ++ FM K    +    +E   +  I  +   +N     KT IVW++  +    + K+TV++IW+      R +       G+ ++ S  +Y++H +YG  W   Y    +N+   +      +GGE CMW E+     +   +WP  CA AE LW  +    N   A  +LE+ RC ++R GI  
Sbjct:   17 ILHYEAGQVFGVWPMPQQITQSTDRYLLSPQSFSFSYSKDSAAQSGCSVLDSAFKRYYSLIFPDAA-------------DGARFSNIWMDPTPFTVSVSVKSGECDGYPDEGSDESYNLSVAAGAAALKAQSVWGALRGLESFSQLVY---QDKYNMYFVNKTEIQDFPRFEFRGLLLDTSRHYLPLNAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSYSYPDLSSKGAFH-PMTHIYTQSDVKRVISHARMRGIRVIPEFDTPGHTQSWGKGQPNLLTPCYKGDVPSGTF-GPVNPILDSTYQFMSGLFKEMKSVFPDSYVHLGGDEVNFACWKSNPNVRAFMTKMGFGHDYTKLESYYIENIVNISSALN-----KTPIVWQDVFDYRERIPKDTVLEIWKGVPADYRTELAKITHAGYRVLLSAPWYINHISYGQDWRNSYTVQPQNFSGTDQQKALVIGGEVCMWGEYVDATNLHPRLWPRACAAAERLWSNEEMTSNVDQAFPRLEKFRCSLIRRGIQA 518

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 306.605 bits (784), Expect = 1.528e-94
Identity = 179/520 (34.42%), Postives = 276/520 (53.08%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKILDKN-------CELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPEL-YIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIW-RSRVDNFHH--IKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYL 1884
            WP PQ I IS     +S +  F+I   N       C L+  A  RY   IF +      +   +++           E   ++ +  + +   +G  P+   DESYQ+ + Q   ++ +   WG LRGLET +QL++   + DY    I    ISD P++ HRG+++DTSRH++P+  +L NL  M MNK NVFHWHI DD SFPF S++ P+L   KGAFH     Y+ + +K V+E+AR RGIRV+ E D PGHT SW K   +LLT C S       F GP+NPIL  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+ FM +    ++ + L   +I +L  +++     K  +VW+E  +    L  +TV+++W  + VD         G   I S  +YLD+ +YG  W ++Y  +  ++          +GGEAC+W E+     ++  +WP   A+ E LW  +  ++   A ++L + RCRM++ GI       P+E LY+
Sbjct:   67 WPLPQKIQISGAAFQLS-SAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNARKQGKNQQKVFDS----------ELQELQVLLTAKDPECDG-YPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVY---EDDYGAHKINKTSISDFPRFAHRGILLDTSRHYLPLKAILTNLEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRKGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTF-GPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIVSAT--NKGYMVWQEVFDNGVKLKGDTVVEVWMNNNVDGELQKVTGSGFTTILSAPWYLDYISYGQDWQKYYKVEPLSFQGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGI-------PAEPLYI 561

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 306.605 bits (784), Expect = 2.289e-94
Identity = 179/520 (34.42%), Postives = 276/520 (53.08%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKILDKN-------CELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPEL-YIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIW-RSRVDNFHH--IKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYL 1884
            WP PQ I IS     +S +  F+I   N       C L+  A  RY   IF +      +   +++           E   ++ +  + +   +G  P+   DESYQ+ + Q   ++ +   WG LRGLET +QL++   + DY    I    ISD P++ HRG+++DTSRH++P+  +L NL  M MNK NVFHWHI DD SFPF S++ P+L   KGAFH     Y+ + +K V+E+AR RGIRV+ E D PGHT SW K   +LLT C S       F GP+NPIL  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+ FM +    ++ + L   +I +L  +++     K  +VW+E  +    L  +TV+++W  + VD         G   I S  +YLD+ +YG  W ++Y  +  ++          +GGEAC+W E+     ++  +WP   A+ E LW  +  ++   A ++L + RCRM++ GI       P+E LY+
Sbjct:   85 WPLPQKIQISGAAFQLS-SAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNARKQGKNQQKVFDS----------ELQELQVLLTAKDPECDG-YPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVY---EDDYGAHKINKTSISDFPRFAHRGILLDTSRHYLPLKAILTNLEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRKGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTF-GPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIVSAT--NKGYMVWQEVFDNGVKLKGDTVVEVWMNNNVDGELQKVTGSGFTTILSAPWYLDYISYGQDWQKYYKVEPLSFQGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGI-------PAEPLYI 579

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 304.294 bits (778), Expect = 1.819e-93
Identity = 178/521 (34.17%), Postives = 273/521 (52.40%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKILDKN-------CELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPEL-YIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV---DNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYL 1884
            WP PQ I IS     +S +  F+I   N       C L+  A  RY   IF +      +   +++           E   ++ +  + +   +G  P+   DESYQ+ + Q   ++ +   WG LRGLET +QL++   + DY    I    ISD P++ HRG+++DTSRH++P+  +L NL  M MNK NVFHWHI DD SFPF S++ P+L   KGAFH     Y+ + +K V+E+AR RGIRV+ E D PGHT SW K   +LLT C S       F GP+NPIL  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+ FM +    ++ + L   +I +L  +++     K  +VW+E  +    L  +T + +W+      D    I   G   + S+ +YL+  +YG  W   Y  D +N+          +GGEAC+W E+     ++  +WP   A+ E LW  +  ++   A ++L + RCRM++ GI       P+E LY+
Sbjct:   85 WPLPQKIQISGAAFQLS-SAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNARKQGKNQQKVFDS----------ELQELQVLLTAKDPECDG-YPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVY---EDDYGAHKINKTSISDFPRFAHRGILLDTSRHYLPLKAILTNLEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRKGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTF-GPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIVSAT--NKGYMVWQEVFDNGVKLKADTQLHVWKENPQYQDEMARITAAGFYTLLSSPWYLNRISYGQDWQAVYKADPQNFNGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGI-------PAEPLYI 580

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Match: hexb (hexosaminidase B (beta polypeptide) [Source:ZFIN;Acc:ZDB-GENE-030131-2333])

HSP 1 Score: 249.98 bits (637), Expect = 1.429e-73
Identity = 160/520 (30.77%), Postives = 247/520 (47.50%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKILDKN-------CELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRV---DNFHHI-KKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGK--RNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYL 1884
            WP PQ I IS     +S +  F+I   N       C L+  A  RY   IF +      +   +++           E   ++ +  + +   +G  P+   DESYQ+ + Q   ++ +   WG LRGLET +QL++   + DY                                         M MNK NVFHWHI DD SFPF S++ P+L  +GAFH     Y+ + +K V+E+AR RGIRV+ E D PGHT SW K   +LLT C S       F GP+NPIL  TY F+   + E+  +FPD ++H+G DEV   CW ++P I+ FM +    ++ + L   +I +L  +++     K  +VW+E  +    L  +T + +W+      D    I   G   + S+ +YL+  +YG  W   Y  D +N+          +GGEAC+W E+     ++  +WP   A+ E LW  +  ++   A ++L + RCRM++ GI       P+E LY+
Sbjct:   85 WPLPQKIQISGAAFQLS-SAGFQITHANGSTAGPSCSLLQNAFRRYFDYIFGNARKQGKNQQKVFDS----------ELQELQVLLTAKDPECDG-YPNLKTDESYQLEVDQPTSVLKAANVWGALRGLETFSQLVY---EDDYG-------------------------------------AEAMAMNKFNVFHWHIVDDHSFPFLSRTFPDLSQRGAFHPYTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGKGQPDLLTPCFSGSSPTGTF-GPVNPILNSTYDFMTRFFKEVSTVFPDAYIHLGGDEVDFSCWKSNPDIQKFMDQQGFGQDYKKLESYYIQRLLDIVSAT--NKGYMVWQEVFDNGVKLKADTQLHVWKENPQYQDEMARITAAGFYTLLSSPWYLNRISYGQDWQAVYKADPQNFNGTAEQKKLVIGGEACLWGEYVDGTNLTPRLWPRASAVGERLWSDENVKDINSAYNRLAKHRCRMVQRGI-------PAEPLYI 542

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Sea Lamprey
Match: hexa (hexosaminidase A (alpha polypeptide) [Source:ZFIN;Acc:ZDB-GENE-050417-283])

HSP 1 Score: 290.812 bits (743), Expect = 3.526e-90
Identity = 166/481 (34.51%), Postives = 266/481 (55.30%), Query Frame = 1

Query:  466 NCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFN--GEIPSENMDE--SYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMT-YSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKK--KFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHH-----IKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISV 1848
             C++++ A  RY   IFS       S     +K++    +K      +  +S+ V+   N   + P        + ++ +  G  L+ +   WG LRGLET +QL +   D+D N + +   ++ D P+++HRGL++DTSRH++P+  +LE L+ M  NKLNVFHWHI DDQSFP+QS++ PEL  KGA++ +   Y+   +  V+ YAR+RGIRVIPE D PGHT SW K    LLT C   + GK+    +GP++P+   TY F+K L+ E+   FPD ++H+G DEV   CW ++P I  FM+K    ++ + L   +I ++ L I  ++ KK  +VW+E  +    L  +TV+ +W+   +++          G   + S  +Y++   YG  W ++Y  +  ++   +      VGGEAC+W E+     ++  +WP   A+AE LW  K    +  A S+L + RCRM+R GI+ 
Sbjct:   23 GCQVLDDAFRRYYNIIFSGSPYPGAS-----SKLHRKPTTKTRAVGEVSLLSVLVQSSHNDCNDFPGLKCLSVLTDELSVQAGESLLQAPSVWGALRGLETFSQLAYRD-DNDGNKILMNKTEVVDFPRFRHRGLLLDTSRHYLPLIVILETLDAMAYNKLNVFHWHIVDDQSFPYQSQTFPELSEKGAYNPSRAIYTETDVGAVIWYARERGIRVIPEFDTPGHTQSWGKGEPNLLTPC---YNGKEPSGLFGPVHPVTNSTYDFMKKLFNEISNAFPDHYIHLGGDEVSFSCWQSNPDITSFMEKMSFGKDYKKLESYYIQQI-LDIVASY-KKGYMVWQEVFDNGVKLKPDTVVHVWKFMAEHYKQEMADVTAAGFSTLLSAPWYINSIAYGQDWTKYYAVEPLDFHGTDKQKELVVGGEACLWGEYVDGTNLTPRLWPRASAVAERLWSDKSVTDVNDAYSRLAKHRCRMVR-GIAA 491

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO49845 (Beta-hexosaminidase [Source:UniProtKB/TrEMBL;Acc:A7RET7])

HSP 1 Score: 273.092 bits (697), Expect = 1.066e-82
Identity = 168/506 (33.20%), Postives = 262/506 (51.78%), Query Frame = 1

Query:  376 GQPWPKPQSISISNQ-FTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMT--YSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWR-------SRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFY---VNDFENYLNLN--YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKR--NFLIAASQLEEQRCRMLRNGI 1842
            G  WP PQ+     + F+ + +  +F I  K  +++  A+ RY    F D ++T        +K+   + ++ I     + + ++              DESY + ++     I ++  WG LRGLET +Q++    D  Y   A G+ KI D P++ HR  MIDTSRH++ +S + + L+ M   K NV HWH+ DDQSFPFQS++ P L  +G+F+ N T  YS   + ++++YAR RGIRVIPE D PGHT SW +S   LLT+C           GP++P ++  Y FLK  + E+   FPD ++H+G DEVG GCW ++P I  +M+K +       L  + ++ +L+  +    K  I+W+E  + +  +  +TV+ +W+       ++V     +K     I S+ +YL++ +YG  W  +Y     DFE         +GG  CMW EF     I    WP   AIAE LW  K   +   A +++ E RCR L  GI
Sbjct:   48 GSIWPNPQAQKPDGKVFSLLPNKFSFSINGKTSDVLKAAVNRYMNLTFPDFTVTKKD-----DKLPFMEGAEVIVVDDYKPMDLTT-------------DESYTLTVTAPQSSIYAYTVWGALRGLETFSQIVHQSEDGMY--YAKGN-KIEDYPRFHHRAFMIDTSRHYLKLSIIKKFLDAMSYAKFNVLHWHVVDDQSFPFQSQTFPSLSDQGSFN-NKTHVYSPADVADIIDYARMRGIRVIPEFDTPGHTYSW-RSIPNLLTKCCDAKGKPTGSLGPIDPTIDSNYDFLKAFFGEVAKRFPDQYIHLGGDEVGFGCWQSNPNITAWMEKMRFGTNYSKLEEY-YETKLLNIIGGLGKQYIIWQEVVDNDVKVLPDTVVNVWKGGWPAELAKVTGAKKLKA----ILSSPWYLNYISYGIDWPNYYKVEPTDFEGTDQEKELVIGGTGCMWGEFVDGTNILARTWPRALAIAERLWSSKSTTDMTSAYARIWEHRCRYLLRGI 525

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BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO26761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TB56])

HSP 1 Score: 201.06 bits (510), Expect = 2.386e-58
Identity = 125/332 (37.65%), Postives = 180/332 (54.22%), Query Frame = 1

Query:  817 AKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECK---SLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHH------IKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN------YVGGEACMWNEFQSKETISQNIWPAMCAIAEILW 1767
             KISD P++  RGL+ID +RHF P+  +  NL  +   K+NVFHWH++DDQ F  +SK +P+L+   +    + Y+ +QIK+VV+YA + GIRVIPEIDVPGH ++   +  EL ++ K   +L R    F   LNP +++TY FL++L+ E+  LFPD + HIG DE     W+ + ++  F KK+ ++    L   F  KL+ +++  F KK L+ W+E   K  N+    VI  WR   +           KKG+  + S  YY+D      S V  Y  D      L        +GGEA MW E  +  TI   IWP   AIAE  W
Sbjct:    1 TKISDTPRFLWRGLLIDAARHFQPVDVIKRNLEALAAVKMNVFHWHLTDDQGFRIESKVYPKLHELAS--DGLYYTQHQIKDVVKYAARLGIRVIPEIDVPGHATAILTAYPELGSKDKYTYTLQRNAGIFDPTLNPTIDKTYEFLENLFAEVTSLFPDEYFHIGGDENEGKHWSENKKMTAFKKKHNLKTNHDLQTYFNIKLEKILS-KFGKK-LMGWDEIMTK--NMPTTAVIHSWRGTTEGLKESTLIEAAKKGYQSVLSNGYYIDRM---QSVVHHYKVDPIGNAKLTPAQRARVLGGEATMWGELVTPLTIDSRIWPRTAAIAERFW 323

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BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO29436 (Beta-hexosaminidase [Source:UniProtKB/TrEMBL;Acc:A7T3N0])

HSP 1 Score: 146.747 bits (369), Expect = 2.018e-37
Identity = 134/449 (29.84%), Postives = 206/449 (45.88%), Query Frame = 1

Query:  385 WPKPQSISISNQFTPVSDNPAFKI-LDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQG-NILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKN----QIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR-VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYV----GGEACMWNE 1698
            WP P+ +  S    P+S   AF I      E++   I RY + I      TH+   +  +++N  K+        +E + ISV+   + E  +E     Y +    G    +++   +G L G+ET +QL   VVD    + ++    ISD P + HRGLM+DT R F P+  L   L+ M   KLNV H+H+SD   F  +SK  P+L      + +  Y+ + ++N+V YAR RGIRV+PE++   H +       + L  C   H G  + Y   N     T   +K + +E+  LFP+   H+GLDEV             F  KN     +++ E  L L  H LQL        K    WEEA     ++T  TVIQ W++  +     +K+      S+ +YL++   G + +Q +  D    LN   V    GGE  MW +
Sbjct:   35 WPLPRELEASGGPLPLS--LAFTIQTSSESEILARGITRYLEII-----TTHLHT-AARSRVNGSKE--------LEVLRISVKS--DDESLNEGTSYEYSLSFDSGPQATLTALTPYGALYGMETFSQL---VVDGSLVYTSV---SISDKPSFVHRGLMLDTGRRFFPMDLLYNTLDAMSYVKLNVLHFHLSDLCRFSVESKLFPDL----RNNESEIYTQDDVRNLVAYARDRGIRVMPEVEGAAHANGLLGLKNKGLQFCN--HSGYTQLY---NDPQGNTLKTMKAILSEMVPLFPEQIFHLGLDEV-------------FTDKNCTLQSLQSFE--LALQEHLLQL-------GKIPAAWEEALSSTKSVTNRTVIQAWKAEGIKTIVDLKQFAINSLSSHFYLNYM--GVTPLQLWT-DIAVGLNETEVQYLLGGEMAMWTD 425

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BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO42823 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0E8])

HSP 1 Score: 88.5817 bits (218), Expect = 4.683e-18
Identity = 68/263 (25.86%), Postives = 115/263 (43.73%), Query Frame = 1

Query:  676 SYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGA---FHINMT-------------------YSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFY-------------------GPLNPILEETYLFLKDLYTELFLLFPD----THVHIGLDEVGKGCW 1329
            S +I++++  I ++     G+  G++TL  L     D +     +    I D P+Y +RG+ +D  R+F+  + +L+ L+ M   K+N FH+H++DD+ +  +     EL   G+   + IN T                   YS +  K +++ A    I+VIPE D+PGH  +  KS        K  +  +   Y                     +NP +E TY F++ + TE+  +  D    T  H G DEV  G W
Sbjct:  252 SLEIKVAEKEIKLTGSHASGVFYGVQTLIAL----ADKENT---VPMVTIKDAPRYGYRGMHLDVGRNFMEKAAVLKLLDAMATYKMNKFHFHLTDDEGWRLEIPGLEELTTVGSKRCYDINTTRCILSQLGSGPSPSTSAQYYSVSDYKEILKRANDLHIQVIPEFDMPGHGYAAIKSMEARFKRLKDSNPSEASKYILSDFNDTSKYLSIQYFTDNAINPCIESTYAFIEKVLTEVKSMHKDIQPLTVYHFGGDEVAHGAW 507

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BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Match: EDO45498 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSQ4])

HSP 1 Score: 87.8113 bits (216), Expect = 7.390e-18
Identity = 68/277 (24.55%), Postives = 119/277 (42.96%), Query Frame = 1

Query:  676 SYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMT-----------------------YSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEK---SNYELLTECKSLHRGKK---------------KFY--GPLNPILEETYLFLKDLYTEL----FLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKK 1365
            S ++  +   ILI+      +  G+++L  L      S Y    +    I D P++++RG+ ID  R+F+P S++L+ ++   M KLN  H H++DD+ +  +    PEL   G+   +                         Y+ ++ ++++ YAR R + VIPE D+PGH  +  K   S Y         ++  +               +F+    +NP LE TY F++ +  ++    F + P    H G DEV  G W   P      +K
Sbjct:  287 SLEVDAAAERILITGVTPLAVFWGVQSLLSLGH----SGY----VPKVTIRDAPRFEYRGMEIDLGRNFMPKSEILKLIDATSMYKLNKLHLHLTDDEGWRLEIPGLPELTTLGSKRCHDPKEHDCIDSQLGSGPGTGNSGTGYYTVSEYRDILRYARDRHVEVIPEFDMPGHGHAAIKAMQSRYRKYLAMGDKYKANQYILSDPLDKSEYLSVQFFTDNAINPCLESTYEFIEHIVFQVRRMHFDVQPLKTFHFGGDEVAHGAWTKSPACAALAQK 555

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Match: hexb (hexosaminidase subunit beta [Source:NCBI gene;Acc:101158618])

HSP 1 Score: 319.316 bits (817), Expect = 9.119e-100
Identity = 183/523 (34.99%), Postives = 275/523 (52.58%), Query Frame = 1

Query:  376 GQPWPKPQSISISNQFTPVSDNPAFKILDK-------NCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHH-----IKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISVGVGSGPSECLY 1881
            G  WP PQ + IS     +S    F+  D        +C L+  A  RY   IF               K++  +++  +E   ++ +SI+         PS   DESY++ +     ++ +   WG L GLET +QL++   + DY    I   K+SD P++ HRG+++D+SRHF+PI  LL NL  M MNK NVFHWHI DDQSFP+ S++ P+L  +GA+H  +  Y+ + +K V+E+AR RGIRVIPE D PGHT SW K   +LLT C S       F GP+NPIL  TY F+   + E+  +FPD +VH+G DEV   CW ++P IK FM +    ++   L   +I KL  ++     KK  I+W+E  +    L  +T+I +W+   + + +        G+  + S+ +YL+  +YG  W   Y  D +++          +GGEAC+W E+     ++  +WP   A+AE LW  K    I  A ++L   RCRM+  GI       P+E L+
Sbjct:   40 GSLWPLPQKVQISEVPLKLS-GATFEFTDAKGSTAGPSCSLLQSAYRRYYDYIFGGPK---------KQKMSRNRRAGPLELTELQ-VSITSPDSQCDGYPSVTSDESYELSVDVPVAVLKAPTVWGALHGLETFSQLVY---EDDYGAKTINSTKVSDFPRFAHRGILLDSSRHFLPIKVLLANLETMAMNKFNVFHWHIVDDQSFPYLSRTFPQLSQQGAYHPYSHVYTPSDVKMVIEFARLRGIRVIPEFDTPGHTQSWGKGQMDLLTPCFSGATPSGSF-GPVNPILNTTYDFMSRFFKEVSDVFPDGYVHLGGDEVDFTCWKSNPDIKKFMDRQGFGQDYSKLESFYIQKLLDIVTTT--KKGYIIWQEVFDNGVKLKPDTLIHVWKGNQEQYQNEMAKITSAGYQTLLSSPWYLNRISYGQDWQSTYKADPQDFKGTEEQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSAKDVTDINDAYNRLSAHRCRMVERGI-------PAEPLF 538

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Match: hexb (hexosaminidase subunit beta [Source:NCBI gene;Acc:101158618])

HSP 1 Score: 318.161 bits (814), Expect = 3.160e-99
Identity = 185/521 (35.51%), Postives = 273/521 (52.40%), Query Frame = 1

Query:  376 GQPWPKPQSISISNQFTPVSDNPAFKILDK-------NCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIK---KGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLN-----YVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLI--AASQLEEQRCRMLRNGISVGVGSGPSECLY 1881
            G  WP PQ + IS     +S    F+  D        +C L+  A  RY   IF               K++  +++  +E   ++ +SI+         PS   DESY++ +     ++ +   WG L GLET +QL++   + DY    I   K+SD P++ HRG+++D+SRHF+PI  LL NL  M MNK NVFHWHI DDQSFP+ S++ P+L  +GA+H  +  Y+ + +K V+E+AR RGIRVIPE D PGHT SW K   +LLT C S       F GP+NPIL  TY F+   + E+  +FPD +VH+G DEV   CW ++P IK FM +    ++   L   +I KL  ++     KK  I+W+E  +    L  +TV+ +W     +    K    G+  I S  +YLD+ +Y   W ++Y  +  N+          +GGEAC+W E+     ++  +WP   A+AE LW  K    I  A ++L   RCRM+  GI       P+E L+
Sbjct:   40 GSLWPLPQKVQISEVPLKLS-GATFEFTDAKGSTAGPSCSLLQSAYRRYYDYIFGGPK---------KQKMSRNRRAGPLELTELQ-VSITSPDSQCDGYPSVTSDESYELSVDVPVAVLKAPTVWGALHGLETFSQLVY---EDDYGAKTINSTKVSDFPRFAHRGILLDSSRHFLPIKVLLANLETMAMNKFNVFHWHIVDDQSFPYLSRTFPQLSQQGAYHPYSHVYTPSDVKMVIEFARLRGIRVIPEFDTPGHTQSWGKGQMDLLTPCFSGATPSGSF-GPVNPILNTTYDFMSRFFKEVSDVFPDGYVHLGGDEVDFTCWKSNPDIKKFMDRQGFGQDYSKLESFYIQKLLDIVTTT--KKGYIIWQEVFDNGVKLKPDTVVHVWMGSGSDAEMNKVTTAGYTTILSAPWYLDYISYAQDWQKYYKVEPLNFNGTEEQKKLVIGGEACLWGEYVDATNLTPRLWPRASAVAERLWSAKDVTDINDAYNRLSAHRCRMVERGI-------PAEPLF 536

[Close]

BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Match: hexa (beta-hexosaminidase subunit alpha [Source:NCBI gene;Acc:101172329])

HSP 1 Score: 283.493 bits (724), Expect = 1.248e-85
Identity = 167/519 (32.18%), Postives = 269/519 (51.83%), Query Frame = 1

Query:  349 IWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILD--------KNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFH-INMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQI-ENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWR-----SRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYV------NDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKR---NFLIAASQLEEQRCRMLR 1833
            I++A   +V   WP P +++ S +  P+  NP     D        + C L++ A  RY   IF D +  +  ++   N   S              + IS ++      P+++  E Y + +S G   +++   WG+LRGLET +QL++     D     + +  I D P+++ RG+++DTSRH++P+  +L+ L+ M  +K NVFHWHI DD SFP+QS+S PEL  KGAFH     Y+ + ++ V+ YAR RGIRV+PE D PGHT SW K    LLT C         F GP+NP L+ TY F+   + E+  +FPD+++H+G DEV   CW ++P ++ FM+K     +   L   +I  +  + + N   KT IVW++  + +   +  +V+++W+      +V      K G  +I ++ +YLD      +W ++Y          E    L  +GGE CMW E+     +   +WP   A AE LW  ++   +   A  +LE+ RC++LR
Sbjct:   24 IFYAGLNAVKGVWPLPHALTSSVEQYPL--NPQTFAFDYGKHSATQQGCSLLDAAFRRYFLLIFPDYTAENGQLEVAANNSFS--------------LYISTDHNDCENYPNDDSSERYNLSVSAGQASLNAATVWGILRGLETFSQLVY---QDDLGSYFVNETFIEDFPRFQFRGVLLDTSRHYLPVHAILKTLDAMSYSKFNVFHWHIVDDPSFPYQSRSFPELSKKGAFHPATHIYTQSDVRRVISYARMRGIRVLPEFDSPGHTGSWGKGQSHLLTPCYKGGAPSGTF-GPVNPALQSTYQFMASFFKEVTSVFPDSYIHLGGDEVDFSCWRSNPHVRAFMQKMGFGGDFPKLEAFYIENIVNITSAN--NKTSIVWQDVFDYHERRSALSVVEVWKHGCYLCKVRQV--TKAGLRVILASPWYLDLPGPTHNWARYYTVWPLAFPGSEKQKRL-VIGGEVCMWGEYVDATNLFPKLWPRASAAAERLWSDEKQTSSVEKAFPRLEDFRCKLLR 517

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BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000008181.1 (SMESG000008181.1)

HSP 1 Score: 1343.18 bits (3475), Expect = 0.000e+0
Identity = 646/648 (99.69%), Postives = 646/648 (99.69%), Query Frame = 1

Query:  166 LQFSPNIPASIAEMKGIEKIKLESLDSYNLTAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNLMFIVLLLITCLYFLYS 2109
            LQFSPNIPASIAEMKGIEKIKLESLDSYN TAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSN MFIVLLLITCLYFLYS
Sbjct:   10 LQFSPNIPASIAEMKGIEKIKLESLDSYNRTAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNFMFIVLLLITCLYFLYS 657

[Close]

BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000008181.1 (SMESG000008181.1)

HSP 1 Score: 1338.17 bits (3462), Expect = 0.000e+0
Identity = 646/650 (99.38%), Postives = 646/650 (99.38%), Query Frame = 1

Query:  166 LQFSPNIPASIAEMKGIEKIKLESLDSYNLTAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNN--LTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNLMFIVLLLITCLYFLYS 2109
            LQFSPNIPASIAEMKGIEKIKLESLDSYN TAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNN  LTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSN MFIVLLLITCLYFLYS
Sbjct:   10 LQFSPNIPASIAEMKGIEKIKLESLDSYNRTAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNNNVKLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNFMFIVLLLITCLYFLYS 659

[Close]

BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000008181.1 (SMESG000008181.1)

HSP 1 Score: 1328.54 bits (3437), Expect = 0.000e+0
Identity = 646/677 (95.42%), Postives = 646/677 (95.42%), Query Frame = 1

Query:  166 LQFSPNIPASIAEMKGIEKIKLESLDSYNLTAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHK-----------------------------LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNLMFIVLLLITCLYFLYS 2109
            LQFSPNIPASIAEMKGIEKIKLESLDSYN TAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHK                             LQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSN MFIVLLLITCLYFLYS
Sbjct:   10 LQFSPNIPASIAEMKGIEKIKLESLDSYNRTAYYDENLQKFVFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSKFIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKQRKFTQGKVSFYGRGTKTRSFHFRICDLQLQLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVNDFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFLIAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFSLHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNFMFIVLLLITCLYFLYS 686

[Close]

BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000002681.1 (SMESG000002681.1)

HSP 1 Score: 363.614 bits (932), Expect = 3.450e-114
Identity = 204/549 (37.16%), Postives = 311/549 (56.65%), Query Frame = 1

Query:  346 HIWHAPTASVGQPWPKPQSISISN---QFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNK--INSCKKSKFIETCTIEK----ISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHI-NMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKL-----QLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR--VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVND----------FENYLNL--------NYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFL----IAASQLEEQRCRMLRNGISVGVGSGPSEC 1875
            H+W AP  + GQ WP P S+       +  P SDN  FK+ + N  ++  A+ RYK  I + K++++      + +  +N+  +   +    ++     ++I VE   + + PS  M+E+YQI +S   I IS+ +TWG LRGLE+L+Q+M+    +    + I + K+ D P++KHRG+M+DT+RHFIP   +++NL+ M MNK+NVFHWH++DDQSFP  +++H E  + GA+   +  Y    +K ++EYAR RGIRVIPEID P HT SW KS+ E++T C  ++      YGP+N     TY  L  LY ++  LFPD  +H+G DEV   C +++  I+ +M+   + +V+ L+  +  KL     QL ++ N  ++  IVW+EA E+N+ L K T++Q+W+S+   +     K+   +IYS  +YLD   YGA W+  Y  D            +Y+N+        N +GGEA MW EF   + +   IWP   A AE LW    NF+     AAS+LEE RCRM    I  GV SG  +C
Sbjct:  124 HVWRAPFMTFGQIWPHPFSVITRADIYEVCPKSDNLIFKLTNVNNYILQEAVMRYKDIICTQKAVSYYPSHWRHQEPILNNANEGDLLTNAKLKGELHIVNIYVE-SDSHQWPSLYMNETYQISVSLKGIFISAKETWGALRGLESLSQMMW---RTRAGRIFINETKVQDQPRFKHRGVMLDTARHFIPKDIIMKNLDAMVMNKMNVFHWHLTDDQSFPLITENHAEFALHGAYDPEHKVYRPEVVKEIIEYARVRGIRVIPEIDSPSHTLSWRKSHPEVMTRCIDMNGKWSGHYGPVNMAAASTYRLLTSLYKDIINLFPDQWIHLGSDEVATSCLSSNQAIQSWMRSRGMFSVDSLIDFYTRKLQNIITQLGLSNNNKQRGFIVWQEAYERNSVLKKGTIVQLWKSQSTAEAATLAKQNIQVIYSACWYLDRLEYGAQWLNHYQCDPGDEYGNQMVMNDYVNVPVNDNWRENILGGEAAMWLEFLDADNVIPRIWPLASAAAERLW--SPNFINNAEKAASRLEEMRCRMFSRSIPAGVASGAGDC 666

[Close]

BLAST of Beta-hexosaminidase vs. Planmine SMEST
Match: SMESG000002681.1 (SMESG000002681.1)

HSP 1 Score: 363.614 bits (932), Expect = 3.697e-114
Identity = 204/549 (37.16%), Postives = 311/549 (56.65%), Query Frame = 1

Query:  346 HIWHAPTASVGQPWPKPQSISISN---QFTPVSDNPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNK--INSCKKSKFIETCTIEK----ISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGLLRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIPISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHI-NMTYSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRGKKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATDPRIKDFMKKNQIENVELLLVLFIHKL-----QLMINLNFPKKTLIVWEEASEKNNNLTKNTVIQIWRSR--VDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVND----------FENYLNL--------NYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFL----IAASQLEEQRCRMLRNGISVGVGSGPSEC 1875
            H+W AP  + GQ WP P S+       +  P SDN  FK+ + N  ++  A+ RYK  I + K++++      + +  +N+  +   +    ++     ++I VE   + + PS  M+E+YQI +S   I IS+ +TWG LRGLE+L+Q+M+    +    + I + K+ D P++KHRG+M+DT+RHFIP   +++NL+ M MNK+NVFHWH++DDQSFP  +++H E  + GA+   +  Y    +K ++EYAR RGIRVIPEID P HT SW KS+ E++T C  ++      YGP+N     TY  L  LY ++  LFPD  +H+G DEV   C +++  I+ +M+   + +V+ L+  +  KL     QL ++ N  ++  IVW+EA E+N+ L K T++Q+W+S+   +     K+   +IYS  +YLD   YGA W+  Y  D            +Y+N+        N +GGEA MW EF   + +   IWP   A AE LW    NF+     AAS+LEE RCRM    I  GV SG  +C
Sbjct:  134 HVWRAPFMTFGQIWPHPFSVITRADIYEVCPKSDNLIFKLTNVNNYILQEAVMRYKDIICTQKAVSYYPSHWRHQEPILNNANEGDLLTNAKLKGELHIVNIYVE-SDSHQWPSLYMNETYQISVSLKGIFISAKETWGALRGLESLSQMMW---RTRAGRIFINETKVQDQPRFKHRGVMLDTARHFIPKDIIMKNLDAMVMNKMNVFHWHLTDDQSFPLITENHAEFALHGAYDPEHKVYRPEVVKEIIEYARVRGIRVIPEIDSPSHTLSWRKSHPEVMTRCIDMNGKWSGHYGPVNMAAASTYRLLTSLYKDIINLFPDQWIHLGSDEVATSCLSSNQAIQSWMRSRGMFSVDSLIDFYTRKLQNIITQLGLSNNNKQRGFIVWQEAYERNSVLKKGTIVQLWKSQSTAEAATLAKQNIQVIYSACWYLDRLEYGAQWLNHYQCDPGDEYGNQMVMNDYVNVPVNDNWRENILGGEAAMWLEFLDADNVIPRIWPLASAAAERLW--SPNFINNAEKAASRLEEMRCRMFSRSIPAGVASGAGDC 676

The following BLAST results are available for this feature:

BLAST of Beta-hexosaminidase vs. Ensembl Human
BLAST of Beta-hexosaminidase vs. Ensembl Celegans
BLAST of Beta-hexosaminidase vs. Ensembl Fly
BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
BLAST of Beta-hexosaminidase vs. Ensembl Mouse
BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
BLAST of Beta-hexosaminidase vs. TrEMBL
BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
BLAST of Beta-hexosaminidase vs. Ensembl Sea Lamprey
BLAST of Beta-hexosaminidase vs. Ensembl Yeast
BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
BLAST of Beta-hexosaminidase vs. Ensembl Medaka
BLAST of Beta-hexosaminidase vs. Planmine SMEST

BLAST of Beta-hexosaminidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HEXB	1.871e-97	34.86	hexosaminidase subunit beta [Source:HGNC Symbol;Ac...	[more]
HEXA	2.070e-90	33.60	hexosaminidase subunit alpha [Source:HGNC Symbol;A...	[more]
HEXA	2.704e-90	33.27	hexosaminidase subunit alpha [Source:HGNC Symbol;A...	[more]
HEXA	2.590e-89	33.73	hexosaminidase subunit alpha [Source:HGNC Symbol;A...	[more]
HEXB	4.985e-72	38.23	hexosaminidase subunit beta [Source:HGNC Symbol;Ac...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
hex-1	3.907e-68	31.37	Beta-hexosaminidase A [Source:UniProtKB/Swiss-Pro...	[more]
hex-1	3.907e-68	31.37	Beta-hexosaminidase A [Source:UniProtKB/Swiss-Pro...	[more]
hex-1	3.907e-68	31.37	Beta-hexosaminidase A [Source:UniProtKB/Swiss-Pro...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hexo1	4.047e-51	30.89	gene:FBgn0041630 transcript:FBtr0300774	[more]
Hexo1	4.047e-51	30.89	gene:FBgn0041630 transcript:FBtr0333567	[more]
Hexo1	4.047e-51	30.89	gene:FBgn0041630 transcript:FBtr0073237	[more]
Hexo1	7.848e-51	30.89	gene:FBgn0041630 transcript:FBtr0073235	[more]
fdl	3.019e-48	30.48	gene:FBgn0045063 transcript:FBtr0346633	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hexa	1.102e-98	34.50	hexosaminidase A (alpha polypeptide) [Source:ZFIN;...	[more]
hexb	5.070e-91	33.14	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]
hexa	7.939e-91	33.79	hexosaminidase A (alpha polypeptide) [Source:ZFIN;...	[more]
hexb	3.908e-76	34.35	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]
hexb	1.278e-43	33.09	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hexb	2.193e-93	33.40	hexosaminidase B (beta polypeptide) [Source:NCBI g...	[more]
hexb	6.207e-93	33.33	hexosaminidase B (beta polypeptide) [Source:NCBI g...	[more]
hexb	2.218e-92	36.80	hexosaminidase B (beta polypeptide) [Source:NCBI g...	[more]
hexb	4.227e-88	36.59	hexosaminidase B (beta polypeptide) [Source:NCBI g...	[more]
hexb	3.508e-87	32.37	hexosaminidase B (beta polypeptide) [Source:NCBI g...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Hexb	1.211e-98	34.12	hexosaminidase B [Source:MGI Symbol;Acc:MGI:96074]	[more]
Hexa	1.779e-88	33.27	hexosaminidase A [Source:MGI Symbol;Acc:MGI:96073]	[more]

BLAST of Beta-hexosaminidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P49614\|HEXB_FELCA	9.452e-100	34.88	Beta-hexosaminidase subunit beta OS=Felis catus OX...	[more]
sp\|P20060\|HEXB_MOUSE	8.470e-98	34.12	Beta-hexosaminidase subunit beta OS=Mus musculus O...	[more]
sp\|P07686\|HEXB_HUMAN	3.479e-97	33.59	Beta-hexosaminidase subunit beta OS=Homo sapiens O...	[more]
sp\|Q6AXR4\|HEXB_RAT	5.467e-97	34.97	Beta-hexosaminidase subunit beta OS=Rattus norvegi...	[more]
sp\|Q29548\|HEXB_PIG	6.836e-93	33.84	Beta-hexosaminidase subunit beta OS=Sus scrofa OX=...	[more]

BLAST of Beta-hexosaminidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267DHF5	3.675e-116	35.17	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A267E9J5	7.765e-116	35.17	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A267E3Z4	1.477e-115	35.58	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
Q7Q0Z2	1.553e-113	38.40	Beta-hexosaminidase OS=Anopheles gambiae OX=7165 G...	[more]
A0A1S4H3Q6	3.327e-113	38.40	Beta-hexosaminidase OS=Anopheles gambiae OX=7165 P...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hexa	9.571e-97	34.48	beta-hexosaminidase subunit alpha-like [Source:NCB...	[more]
hexb	1.528e-94	34.42	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]
hexb	2.289e-94	34.42	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]
hexb	1.819e-93	34.17	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]
hexb	1.429e-73	30.77	hexosaminidase B (beta polypeptide) [Source:ZFIN;A...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
hexa	3.526e-90	34.51	hexosaminidase A (alpha polypeptide) [Source:ZFIN;...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Beta-hexosaminidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49845	1.066e-82	33.20	Beta-hexosaminidase [Source:UniProtKB/TrEMBL;Acc:...	[more]
EDO26761	2.386e-58	37.65	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29436	2.018e-37	29.84	Beta-hexosaminidase [Source:UniProtKB/TrEMBL;Acc:...	[more]
EDO42823	4.683e-18	25.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45498	7.390e-18	24.55	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Beta-hexosaminidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
hexb	9.119e-100	34.99	hexosaminidase subunit beta [Source:NCBI gene;Acc:...	[more]
hexb	3.160e-99	35.51	hexosaminidase subunit beta [Source:NCBI gene;Acc:...	[more]
hexa	1.248e-85	32.18	beta-hexosaminidase subunit alpha [Source:NCBI gen...	[more]

BLAST of Beta-hexosaminidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000008181.1	0.000e+0	99.69	SMESG000008181.1	[more]
SMESG000008181.1	0.000e+0	99.38	SMESG000008181.1	[more]
SMESG000008181.1	0.000e+0	95.42	SMESG000008181.1	[more]
SMESG000002681.1	3.450e-114	37.16	SMESG000002681.1	[more]
SMESG000002681.1	3.697e-114	37.16	SMESG000002681.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30026336 ID=SMED30026336|Name=Beta-hexosaminidase|organism=Schmidtea mediterranea sexual|type=transcript|length=2276bp
CTTGAAATTACATCTGTAATTTGGTTGTTGAATAGCCAACTAATAAACAA
TAGAAAACCAAGGTTGAACGTGATTGTATTTGATTCTCAATTCGAACAAA
CTGGCTGTCATTTAATGATCGATAATTAAATTATTACGATGATTATTGCA
ATATGTCTAATTATTTTGCAGTTCTCTCCCAATATTCCGGCTTCTATTGC
TGAAATGAAAGGAATAGAAAAAATTAAACTAGAATCTCTCGATTCATATA
ATCTTACTGCATATTACGACGAAAATCTTCAAAAGTTTGTGTTCGCTGAT
TCTCCTGAAAGATTTGCTAAAGAGAAAAGCCCAGTCCACGAATATCACAT
ATGGCATGCTCCAACAGCCAGCGTTGGACAACCTTGGCCGAAGCCACAGT
CAATATCCATATCAAATCAGTTTACTCCAGTATCGGACAATCCAGCTTTT
AAAATTCTAGATAAAAATTGTGAACTGATTAACTTGGCAATTGAACGGTA
CAAGAAACGAATTTTTTCCGATAAAAGTATCACTCATGTCTCAGTTGACA
GCATTTATAATAAGATTAATTCTTGCAAAAAGAGCAAATTTATTGAAACA
TGCACTATAGAAAAAATATCCATCTCAGTCGAGTATTGTTTCAATGGAGA
AATTCCCAGTGAAAACATGGATGAATCATATCAAATAAGACTATCGCAAG
GAAATATTTTAATTTCCAGCCATCAAACATGGGGATTATTAAGAGGTTTG
GAAACATTGGCCCAGTTAATGTTTGTCGTTGTAGACTCAGATTATAACTG
GCTGGCTATAGGAGACGCAAAGATATCTGATAATCCGAAGTATAAGCATC
GAGGGCTTATGATAGATACAAGCCGGCATTTCATCCCTATATCCAAGTTG
CTGGAAAATTTGAATGGCATGGAAATGAATAAATTGAATGTGTTTCACTG
GCATATTTCGGATGATCAGTCATTTCCATTTCAAAGCAAATCTCATCCCG
AACTGTATATCAAAGGAGCTTTTCACATTAACATGACTTATAGTTATAAT
CAAATTAAAAATGTTGTTGAATATGCTCGTCAAAGGGGTATCCGAGTAAT
TCCTGAGATAGATGTCCCAGGTCACACGTCTTCTTGGGAGAAAAGCAATT
ATGAATTACTGACTGAATGTAAATCATTGCACAGAGGCAAAAAAAAGTTT
TACGGTCCATTGAACCCGATCTTAGAAGAAACTTATCTATTTTTGAAAGA
TCTGTATACTGAATTGTTTCTTCTGTTTCCTGATACTCATGTTCATATCG
GTTTAGATGAAGTTGGTAAAGGATGCTGGGCAACTGATCCGAGAATTAAA
GACTTTATGAAAAAGAATCAAATAGAAAATGTCGAATTGTTGCTAGTTTT
ATTTATTCACAAATTGCAATTAATGATAAATTTAAATTTTCCTAAGAAAA
CATTAATAGTATGGGAAGAGGCTTCAGAAAAAAATAACAATCTGACGAAG
AATACTGTAATCCAAATCTGGAGAAGTCGGGTGGACAATTTTCATCATAT
CAAAAAAGGTCATCCTATAATATACTCTACTAGTTATTACCTAGATCACG
CCACATACGGCGCCTCTTGGGTCCAGTTCTATGTGAATGATTTTGAAAAC
TATTTGAATCTCAATTATGTTGGAGGTGAAGCGTGCATGTGGAATGAGTT
TCAGTCTAAGGAGACAATTTCGCAAAATATTTGGCCTGCTATGTGCGCAA
TCGCGGAAATTTTGTGGTTTGGCAAGAGAAACTTTTTGATAGCAGCTAGT
CAGCTGGAAGAACAGAGATGTCGAATGCTGAGAAACGGAATAAGTGTTGG
TGTTGGCAGTGGCCCGAGTGAATGTTTATATTTACCAGACGACATTCACA
TTTCTTTTAATTTATCGTGCCATTATCATACATTTTCGTTGCATGGATTC
CCGAAATTGACTGGAATTCTTAAAGCCTCCTTGATGTTCGTGCTGGGCTT
CATGACCCACTTCTGGATCCAAATGATTATTCGACACAAGAAAAAGATAT
ATTCAAATCTCATGTTTATTGTCCTACTACTGATCACTTGTCTATATTTT
TTATATTCCTAAGAGAAATGCCTCGAGTGAATACTGGATTGCATTTTAAT
GATATTATTTTATTTATGCAGAAAAGTCTTTTTCGAAATTATTTTGTTTG
TTTAGTTATATTTTGCCTTTTGTCGTTTATTTAACAGTTGATGCCAATAA
TATATTATTATGTATGGGTATGAACC

protein sequence of SMED30026336-orf-1

>SMED30026336-orf-1 ID=SMED30026336-orf-1|Name=SMED30026336-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=658bp
MIIAICLIILQFSPNIPASIAEMKGIEKIKLESLDSYNLTAYYDENLQKF
VFADSPERFAKEKSPVHEYHIWHAPTASVGQPWPKPQSISISNQFTPVSD
NPAFKILDKNCELINLAIERYKKRIFSDKSITHVSVDSIYNKINSCKKSK
FIETCTIEKISISVEYCFNGEIPSENMDESYQIRLSQGNILISSHQTWGL
LRGLETLAQLMFVVVDSDYNWLAIGDAKISDNPKYKHRGLMIDTSRHFIP
ISKLLENLNGMEMNKLNVFHWHISDDQSFPFQSKSHPELYIKGAFHINMT
YSYNQIKNVVEYARQRGIRVIPEIDVPGHTSSWEKSNYELLTECKSLHRG
KKKFYGPLNPILEETYLFLKDLYTELFLLFPDTHVHIGLDEVGKGCWATD
PRIKDFMKKNQIENVELLLVLFIHKLQLMINLNFPKKTLIVWEEASEKNN
NLTKNTVIQIWRSRVDNFHHIKKGHPIIYSTSYYLDHATYGASWVQFYVN
DFENYLNLNYVGGEACMWNEFQSKETISQNIWPAMCAIAEILWFGKRNFL
IAASQLEEQRCRMLRNGISVGVGSGPSECLYLPDDIHISFNLSCHYHTFS
LHGFPKLTGILKASLMFVLGFMTHFWIQMIIRHKKKIYSNLMFIVLLLIT
CLYFLYS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR025705	Beta_hexosaminidase_sua/sub
IPR015883	Glyco_hydro_20_cat
IPR029018	Hex-like_dom2
IPR029019	HEX_eukaryotic_N
IPR013781	Glyco_hydro_catalytic_dom
IPR017853	Glycoside_hydrolase_SF

Vocabulary: **biological process**
Term	Definition
GO:0005975	carbohydrate metabolic process
GO:0008152	metabolic process

Vocabulary: **molecular function**
Term	Definition
GO:0004563	beta-N-acetylhexosaminidase activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR025705	Beta-hexosaminidase	PRINTS	PR00738	GLHYDRLASE20	coord: 510..526 score: 33.69 coord: 358..376 score: 33.73 coord: 190..210 score: 41.13 coord: 527..544 score: 32.83 coord: 380..393 score: 48.05 coord: 229..246 score: 55.05 coord: 258..279 score: 51.65 coord: 312..329 score: 68.18
IPR025705	Beta-hexosaminidase	PIRSF	PIRSF001093	B-hxosamndse_ab_euk_	coord: 45..585 e-value: 6.3E-138 score: 458.4
IPR029019	Beta-hexosaminidase, eukaryotic type, N-terminal	PFAM	PF14845	Glycohydro_20b2	coord: 82..210 e-value: 4.8E-15 score: 56.4
IPR015883	Glycoside hydrolase family 20, catalytic domain	PFAM	PF00728	Glyco_hydro_20	coord: 235..544 e-value: 1.2E-78 score: 265.0
IPR029018	Beta-hexosaminidase-like, domain 2	GENE3D	G3DSA:3.30.379.10		coord: 77..232 e-value: 4.5E-26 score: 93.8
IPR029018	Beta-hexosaminidase-like, domain 2	SUPERFAMILY	SSF55545	beta-N-acetylhexosaminidase-like domain	coord: 83..234
None	No IPR available	GENE3D	G3DSA:3.20.20.80		coord: 233..579 e-value: 3.6E-109 score: 367.1
None	No IPR available	PANTHER	PTHR22600	BETA-HEXOSAMINIDASE	coord: 76..570
None	No IPR available	PANTHER	PTHR22600:SF20	BETA-HEXOSAMINIDASE A	coord: 76..570
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..18 score: 0.552
None	No IPR available	TMHMM	TMhelix		coord: 608..630
None	No IPR available	TMHMM	TMhelix		coord: 637..656
IPR017853	Glycoside hydrolase superfamily	SUPERFAMILY	SSF51445	(Trans)glycosidases	coord: 235..570

Main menu

Beta-hexosaminidase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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