Protein kinase domain-containing protein

Overview
NameProtein kinase domain-containing protein
Smed IDSMED30026298
Length (bp)1730
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein kinase domain-containing protein (SMED30026298) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30026298) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30026298) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30026298) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30026298

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30026298SMESG000014613.1 dd_Smed_v4_4447_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30026298SMESG000014613.1 dd_Smed_v4_4447_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30026298SMESG000027219.1 SMESG000014613.1 OX_Smed_1.0.22066ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30026298SMESG000014619.1 dd_Smed_v4_1212_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 104.375 bits (259), Expect = 7.306e-23
Identity = 54/137 (39.42%), Postives = 83/137 (60.58%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    + + GT        ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT-----PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 570
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 104.375 bits (259), Expect = 7.901e-23
Identity = 54/137 (39.42%), Postives = 83/137 (60.58%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    + + GT        ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  466 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT-----PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 597
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 104.375 bits (259), Expect = 8.039e-23
Identity = 54/137 (39.42%), Postives = 83/137 (60.58%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    + + GT        ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  435 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT-----PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 566
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 104.375 bits (259), Expect = 8.046e-23
Identity = 54/137 (39.42%), Postives = 83/137 (60.58%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    + + GT        ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  470 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT-----PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 601
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 104.375 bits (259), Expect = 8.046e-23
Identity = 54/137 (39.42%), Postives = 83/137 (60.58%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    + + GT        ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  470 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT-----PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 601
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-2 (Serine/threonine-protein kinase pak-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EFU0])

HSP 1 Score: 90.1225 bits (222), Expect = 7.855e-19
Identity = 61/189 (32.28%), Postives = 93/189 (49.21%), Query Frame = 1 
Query:  949 YKYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMI-FKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCI 1509
            Y++P  V   + +   D L++V E M GGSL   ++   +    I    +Q+L  L F+H  K+IHR+I   S+LL   G VKL++F    F   LS ++   + + GT         A EV+  EPY  +ADIWSFG  LIE+V  E P+      +A+  I  + +  + R         E++  CI
Sbjct:  281 YQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDF---GFCGQLSEEVPRRRSLVGT-----PYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCI 461
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-2 (Serine/threonine-protein kinase pak-2 [Source:UniProtKB/Swiss-Prot;Acc:G5EFU0])

HSP 1 Score: 90.1225 bits (222), Expect = 7.916e-19
Identity = 61/189 (32.28%), Postives = 93/189 (49.21%), Query Frame = 1 
Query:  949 YKYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMI-FKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCI 1509
            Y++P  V   + +   D L++V E M GGSL   ++   +    I    +Q+L  L F+H  K+IHR+I   S+LL   G VKL++F    F   LS ++   + + GT         A EV+  EPY  +ADIWSFG  LIE+V  E P+      +A+  I  + +  + R         E++  CI
Sbjct:  283 YQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDF---GFCGQLSEEVPRRRSLVGT-----PYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCI 463
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: F26E4.5 (Tyrosine-protein kinase [Source:UniProtKB/TrEMBL;Acc:O01325])

HSP 1 Score: 86.2705 bits (212), Expect = 1.167e-17
Identity = 52/155 (33.55%), Postives = 88/155 (56.77%), Query Frame = 1 
Query:  937 LKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIK--YCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            LKL++KY  V L  + T+Q+ + IV E   GG L+ ++     + S ++K  YC+QI +G++++  +++IHR++   +VLLD   N K+S+F  S F        + K  K  ++      +APE LL   Y  ++D+WSFG  + E+ + E PY
Sbjct:  251 LKLNHKY-VVRLYGVATQQEPIMIVMELCSGGCLKSRIEKKDEQLSDVLKRKYCKQIAKGMRYLEKKQVIHRDLAARNVLLDKSDNCKISDFGLSLF------GKLHKEQKLMKV--PIRWLAPETLLKGIYSSKSDVWSFGVVMFEVFSGEYPY 396
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 85.8853 bits (211), Expect = 1.610e-17
Identity = 50/145 (34.48%), Postives = 78/145 (53.79%), Query Frame = 1 
Query:  961 FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
             V  L  Y   D L++V E + GGSL   ++   +E  +I   C+++L+ L+F+H   +IHR+I   ++LL   G+VKL++F    F   LS +      K T +      +APEV+  + YG + D+WS G   IE+V  E PY
Sbjct:  303 IVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDF---GFCAQLSPEQ----RKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPY 440
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 85.8853 bits (211), Expect = 1.857e-17
Identity = 50/145 (34.48%), Postives = 78/145 (53.79%), Query Frame = 1 
Query:  961 FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
             V  L  Y   D L++V E + GGSL   ++   +E  +I   C+++L+ L+F+H   +IHR+I   ++LL   G+VKL++F    F   LS +      K T +      +APEV+  + YG + D+WS G   IE+V  E PY
Sbjct:  349 IVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFG---FCAQLSPEQ----RKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPY 486
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0100470)

HSP 1 Score: 89.3521 bits (220), Expect = 3.773e-18
Identity = 69/220 (31.36%), Postives = 103/220 (46.82%), Query Frame = 1 
Query:  952 KYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI-----APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFS-KFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGE-----PYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNSN 1575
            K+P  VEL   ++  D L+++ E   GG+L    SI      PL    I   C+ + EGL F+H  K+IHR++  G+VLL  +G VKL++F  S K  + +     F G            +APE++L E     PY  + DIWS G TLIE+   E P  + +    +  I K +    E+       F++ + K +      RPT   L+   F N N
Sbjct:   90 KHPNIVELYEAFSIDDKLWMLIEYCDGGALD---SIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGT--------PYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRN 298
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0072363)

HSP 1 Score: 89.3521 bits (220), Expect = 4.363e-18
Identity = 69/220 (31.36%), Postives = 103/220 (46.82%), Query Frame = 1 
Query:  952 KYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI-----APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFS-KFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGE-----PYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNSN 1575
            K+P  VEL   ++  D L+++ E   GG+L    SI      PL    I   C+ + EGL F+H  K+IHR++  G+VLL  +G VKL++F  S K  + +     F G            +APE++L E     PY  + DIWS G TLIE+   E P  + +    +  I K +    E+       F++ + K +      RPT   L+   F N N
Sbjct:   90 KHPNIVELYEAFSIDDKLWMLIEYCDGGALD---SIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGT--------PYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRN 298
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0332925)

HSP 1 Score: 89.3521 bits (220), Expect = 4.438e-18
Identity = 69/220 (31.36%), Postives = 103/220 (46.82%), Query Frame = 1 
Query:  952 KYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI-----APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFS-KFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGE-----PYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNSN 1575
            K+P  VEL   ++  D L+++ E   GG+L    SI      PL    I   C+ + EGL F+H  K+IHR++  G+VLL  +G VKL++F  S K  + +     F G            +APE++L E     PY  + DIWS G TLIE+   E P  + +    +  I K +    E+       F++ + K +      RPT   L+   F N N
Sbjct:   90 KHPNIVELYEAFSIDDKLWMLIEYCDGGALD---SIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGT--------PYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRN 298
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0072366)

HSP 1 Score: 86.2705 bits (212), Expect = 4.178e-17
Identity = 67/217 (30.88%), Postives = 102/217 (47.00%), Query Frame = 1 
Query:  952 KYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI--APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFS-KFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGE-----PYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNSN 1575
            K+P  VEL   ++  D L+++ E   GG+L   +     PL    I   C+ + EGL F+H  K+IHR++  G+VLL  +G VKL++F  S K  + +     F G            +APE++L E     PY  + DIWS G TLIE+   E P  + +    +  I K +    E+       F++ + K +      RPT   L+   F N N
Sbjct:   90 KHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGT--------PYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRN 298
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0072364)

HSP 1 Score: 86.2705 bits (212), Expect = 4.178e-17
Identity = 67/217 (30.88%), Postives = 102/217 (47.00%), Query Frame = 1 
Query:  952 KYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI--APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFS-KFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGE-----PYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNSN 1575
            K+P  VEL   ++  D L+++ E   GG+L   +     PL    I   C+ + EGL F+H  K+IHR++  G+VLL  +G VKL++F  S K  + +     F G            +APE++L E     PY  + DIWS G TLIE+   E P  + +    +  I K +    E+       F++ + K +      RPT   L+   F N N
Sbjct:   90 KHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGT--------PYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRN 298
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 104.76 bits (260), Expect = 3.889e-23
Identity = 54/139 (38.85%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   G++   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ +F
Sbjct:  436 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSSTGVRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEF 570
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 104.76 bits (260), Expect = 3.926e-23
Identity = 54/139 (38.85%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   G++   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ +F
Sbjct:  430 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSSTGVRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEF 564
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 104.375 bits (259), Expect = 4.949e-23
Identity = 54/139 (38.85%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   G++   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ +F
Sbjct:  418 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSSTGVRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEF 552
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 104.375 bits (259), Expect = 5.083e-23
Identity = 57/142 (40.14%), Postives = 85/142 (59.86%), Query Frame = 1 
Query:  985 TEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            T +  L I  E MPGGS++ QL S   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  S+ L  +  +    K + GT        ++PEV+ GE YG +ADIWS G T++E++T+  P+ +F
Sbjct:  434 THEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGT-----PYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEF 570
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 103.99 bits (258), Expect = 6.207e-23
Identity = 57/142 (40.14%), Postives = 85/142 (59.86%), Query Frame = 1 
Query:  985 TEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            T +  L I  E MPGGS++ QL S   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  S+ L  +  +    K + GT        ++PEV+ GE YG +ADIWS G T++E++T+  P+ +F
Sbjct:  426 THEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGT-----PYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEF 562
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 103.605 bits (257), Expect = 1.317e-22
Identity = 56/142 (39.44%), Postives = 85/142 (59.86%), Query Frame = 1 
Query:  985 TEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +++  L I  E MPGGS++ QL +   L   V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    K + GT        ++PEV+ GE YG +ADIWS G T++E++T + P+ +F
Sbjct:  439 SQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGT-----PYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEF 575
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 103.219 bits (256), Expect = 1.766e-22
Identity = 56/142 (39.44%), Postives = 85/142 (59.86%), Query Frame = 1 
Query:  985 TEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +++  L I  E MPGGS++ QL +   L   V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    K + GT        ++PEV+ GE YG +ADIWS G T++E++T + P+ +F
Sbjct:  411 SQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGT-----PYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEF 547
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 102.449 bits (254), Expect = 2.874e-22
Identity = 53/139 (38.13%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  +Y +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   GI+   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  439 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGIRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 573
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 102.064 bits (253), Expect = 3.540e-22
Identity = 53/139 (38.13%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  +Y +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   GI+   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  421 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGIRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 555
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 96.2857 bits (238), Expect = 2.718e-20
Identity = 51/136 (37.50%), Postives = 82/136 (60.29%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  +V  +Y +QIL+G+ ++H   I+HR+I   ++L D  GNVKL +F  SK +  +   M   GIK   +      ++PEV+ GE YG +AD+WS   T++E++T + P+ ++
Sbjct:  431 LSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTIC--MSGTGIKS--VTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEY 562
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 105.145 bits (261), Expect = 2.835e-23
Identity = 55/136 (40.44%), Postives = 83/136 (61.03%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   GI+   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGIRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 570
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 101.293 bits (251), Expect = 5.488e-22
Identity = 54/141 (38.30%), Postives = 84/141 (59.57%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            ++  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GN+KL +F  SK L  +  +    K + GT        ++PEV+ GE YG +ADIWS   T++E++T + P+ +F
Sbjct:  429 QEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGT-----PYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEF 564
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk25 (serine/threonine kinase 25 (yeast) [Source:MGI Symbol;Acc:MGI:1891699])

HSP 1 Score: 87.0409 bits (214), Expect = 6.397e-19
Identity = 50/137 (36.50%), Postives = 73/137 (53.28%), Query Frame = 1 
Query:  982 YTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERP 1392
            Y +   L+I+ E + GGS    L   PLE + I    ++IL+GL ++H E+ IHR+I   +VLL  +G+VKL++F  +  L +         IK          +APEV+    Y F+ADIWS G T IE+   E P
Sbjct:   85 YLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ-------IKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP 214
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk39 (serine/threonine kinase 39 [Source:MGI Symbol;Acc:MGI:1858416])

HSP 1 Score: 90.8929 bits (224), Expect = 9.500e-19
Identity = 62/216 (28.70%), Postives = 108/216 (50.00%), Query Frame = 1 
Query:  976 TMYTEQDNLFIVTEDMPGGSL---------RQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLY---NLSTDMIFKGIKGTRIDDDACCVAPEVLLG-EPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXX-------XXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            T +  +D L++V + + GGS+         R +     LE ++I    +++LEGL ++H    IHR++  G++LL   G+V++++F  S FL    +++ + + K   GT      C +APEV+     Y F+AD+WSFG T IE+ T   PY K+   + + +  +           D E     G +F +++  C+    S RPT + L+   F
Sbjct:  138 TSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGT-----PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKF 348
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk25 (serine/threonine kinase 25 (yeast) [Source:MGI Symbol;Acc:MGI:1891699])

HSP 1 Score: 88.9669 bits (219), Expect = 2.334e-18
Identity = 61/194 (31.44%), Postives = 93/194 (47.94%), Query Frame = 1 
Query:  982 YTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            Y +   L+I+ E + GGS    L   PLE + I    ++IL+GL ++H E+ IHR+I   +VLL  +G+VKL++F  +  L +         IK          +APEV+    Y F+ADIWS G T IE+   E P         +++I K      E   +    F E ++ C++     RPT   L+   F
Sbjct:   85 YLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ-------IKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLE--GHHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O22040|ANP1_ARATH (Mitogen-activated protein kinase kinase kinase ANP1 OS=Arabidopsis thaliana OX=3702 GN=ANP1 PE=1 SV=2)

HSP 1 Score: 110.538 bits (275), Expect = 4.230e-24
Identity = 79/240 (32.92%), Postives = 123/240 (51.25%), Query Frame = 1 
Query:  856 KCVAYAYDYKLTDINSMKILKYEIVTRLKLSYKYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLS-IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYE--RDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            K V  A ++   +     I + E   +L  +  +P  V  L    E D L I+ E +PGGS+   L    P   SV+  Y +Q+L GL+++H+  I+HR+I   ++L+D KG +KL++F  SK +  L+T    K +KGT        +APEV+L   + F ADIWS G T+IE+VT + P+ +  YKE   I        +    D  +    D ++ KC+  + + RPT S L+   F
Sbjct:   98 KQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGT-----PYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQ-QYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLL-KCLQEVPNLRPTASELLKHPF 330
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 105.145 bits (261), Expect = 1.983e-22
Identity = 55/136 (40.44%), Postives = 83/136 (61.03%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   GI+   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGIRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 570
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 104.375 bits (259), Expect = 3.509e-22
Identity = 54/137 (39.42%), Postives = 83/137 (60.58%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            L I  E MPGGS++ QL +   L  SV  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    + + GT        ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT-----PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 570
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9Y2U5|M3K2_HUMAN (Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2)

HSP 1 Score: 102.064 bits (253), Expect = 2.272e-21
Identity = 55/141 (39.01%), Postives = 84/141 (59.57%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            ++  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +  +    K + GT        ++PEV+ GE YG +ADIWS   T++E++T + P+ +F
Sbjct:  429 QEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGT-----PYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEF 564
[Close]
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9FZ36|M3K2_ARATH (Mitogen-activated protein kinase kinase kinase 2 OS=Arabidopsis thaliana OX=3702 GN=ANP2 PE=2 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 1.527e-20
Identity = 71/221 (32.13%), Postives = 114/221 (51.58%), Query Frame = 1 
Query:  910 ILKYEIVTRLKLSYKYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLS-IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYER-DCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            I + E   +L  +  +P  V  L    E + L I+ E +PGGS+   L        SV+  Y  Q+L GL+++H+  I+HR+I   ++L+D +G +KL++F  SK +  L+T    K +KGT        +APEV+L   + F ADIWS G T+IE+VT + P+ +  YKE   I        +        ++ ++ + KC+    + RPT S L+   F
Sbjct:  115 IQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPY-----WMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQ-QYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLKCLQQEPNLRPTASELLKHPF 329
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1S3K2F3 (mitogen-activated protein kinase kinase kinase 3 isoform X2 OS=Lingula unguis OX=7574 GN=LOC106178012 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 1.893e-24
Identity = 68/204 (33.33%), Postives = 108/204 (52.94%), Query Frame = 1 
Query:  961 FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI-APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKN 1569
             V+    + ++  L I  E MPGGS++ Q+ +  PL  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVK+ +F  SK L  + T    K + GT        ++PEV+ G+ YG +AD+WS G T++E++T   P+ +F    AI+ I       YE   +      +I++ C    Q +RP    L+   F N
Sbjct:  409 IVQYYGCHQDEKILSIFMEHMPGGSVKDQIRLYGPLTENVTRKYTRQILEGVTYLHHHMIVHRDIKGANILRDSIGNVKIGDFGASKRLQTICTQTGMKSVTGT-----PYWMSPEVINGDGYGRKADVWSIGCTVVEMLTSSPPWSEFEAMAAIFKIATADTPQYELPAHVSLVARDILELCFRKNQKDRPYAEELLKHRFVN 607
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2P6QMP9 (Putative mitogen-activated protein kinase kinase kinase STE-STE11 family OS=Rosa chinensis OX=74649 GN=RchiOBHm_Chr5g0080301 PE=3 SV=1)

HSP 1 Score: 115.161 bits (287), Expect = 1.973e-24
Identity = 71/204 (34.80%), Postives = 112/204 (54.90%), Query Frame = 1 
Query:  964 VELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEP--YGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKN 1569
            + LL+ +  ++ L+I+ E +  GSLR+     PL  S +  Y +QIL+GLK++HD+ +IHR+I C ++L+   G+VKL++F  +K +   + DM+    +GT     A  +APEV+  E   YG  ADIWS G T++E++TRE PYP   +  A   I   K               + I +C+     NRPT + L++  F N
Sbjct:  126 IALLSQFEHENILYILLELVTEGSLRKLYQTYPLTDSHVSVYTRQILQGLKYLHDQNVIHRDIKCANILVHANGSVKLADFGLAKAIK--TNDML--SCQGT-----ANWMAPEVVNPESPGYGLPADIWSLGCTVLEMLTREVPYPNLEWMAAACKIMMGKLPLVPDSL--SREAQDFIHRCLQVKPDNRPTAAQLLEHPFVN 318
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1S3K1D9 (mitogen-activated protein kinase kinase kinase 3 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106178012 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 2.031e-24
Identity = 68/204 (33.33%), Postives = 108/204 (52.94%), Query Frame = 1 
Query:  961 FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSI-APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKN 1569
             V+    + ++  L I  E MPGGS++ Q+ +  PL  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVK+ +F  SK L  + T    K + GT        ++PEV+ G+ YG +AD+WS G T++E++T   P+ +F    AI+ I       YE   +      +I++ C    Q +RP    L+   F N
Sbjct:  437 IVQYYGCHQDEKILSIFMEHMPGGSVKDQIRLYGPLTENVTRKYTRQILEGVTYLHHHMIVHRDIKGANILRDSIGNVKIGDFGASKRLQTICTQTGMKSVTGT-----PYWMSPEVINGDGYGRKADVWSIGCTVVEMLTSSPPWSEFEAMAAIFKIATADTPQYELPAHVSLVARDILELCFRKNQKDRPYAEELLKHRFVN 635
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0L8HR14 (Protein kinase domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22008257mg PE=4 SV=1)

HSP 1 Score: 118.627 bits (296), Expect = 2.385e-24
Identity = 73/189 (38.62%), Postives = 102/189 (53.97%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            L I  E MPGGSLRQQL +  PL  ++  KY +Q+LEGL F+H   I+HR+I C ++L + +GNVKL +F  SK L ++ +    K + GT        +APEV+ GE Y  +ADIWS G T++E+ T + P+P      AIY I   +   YE   +      + I  C       RPT   L+   F
Sbjct:  440 LSIFMEYMPGGSLRQQLQNYGPLNENLARKYTRQVLEGLAFLHKNVIVHRDIKCANILKNVQGNVKLGDFGASKRLQSICSMSGMKTVIGT-----PHWMAPEVINGEGYCRKADIWSLGCTVVEMFTMKPPWPDLESMAAIYKIATSEHPKYELPFHVSDIARDCIRNCFRKNSRERPTAEDLLRHRF 623
[Close]
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A453KRF3 (Protein kinase domain-containing protein OS=Aegilops tauschii subsp. strangulata OX=200361 PE=4 SV=1)

HSP 1 Score: 108.997 bits (271), Expect = 4.767e-23
Identity = 59/146 (40.41%), Postives = 89/146 (60.96%), Query Frame = 1 
Query:  961 FVELLTMYTEQDNLFIVTEDMPGGSLRQQLS-IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
             V  L    E+D L I+ E +PGGS++  L  +     +VI KY +QIL+GL+++H   IIHR+I   ++L+D KG +KL++F  SK +  L+T    K +KGT        +APEV++G  + F ADIWS G T+IE+ T + P+
Sbjct:   19 IVRYLGTVREEDTLNILLEFVPGGSIQSLLGKLGSFPEAVIRKYTRQILQGLEYLHSNAIIHRDIKGANILVDNKGCIKLADFGASKQVAKLATMTAAKTMKGT-----PHWMAPEVIVGSGHTFSADIWSVGCTVIEMATGKPPW 159
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704])

HSP 1 Score: 102.449 bits (254), Expect = 1.760e-22
Identity = 57/142 (40.14%), Postives = 84/142 (59.15%), Query Frame = 1 
Query:  985 TEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            T +  L I  E MPGGS++ QL S   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  S+ L  +  +    K + GT        ++PEV+ GE YG +ADIWS G T++E++T   P+ +F
Sbjct:  431 THERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGT-----PYWMSPEVISGEGYGRKADIWSVGCTVVEMLTLRPPWAEF 567
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 102.064 bits (253), Expect = 2.626e-22
Identity = 52/139 (37.41%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   G++   +      ++PEV+ G+ YG +AD+WS G T++E++T + P+ ++
Sbjct:  430 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSSTGVRS--VTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEY 564
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 102.064 bits (253), Expect = 2.626e-22
Identity = 52/139 (37.41%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   G++   +      ++PEV+ G+ YG +AD+WS G T++E++T + P+ ++
Sbjct:  430 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSSTGVRS--VTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEY 564
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 102.064 bits (253), Expect = 2.626e-22
Identity = 52/139 (37.41%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   G++   +      ++PEV+ G+ YG +AD+WS G T++E++T + P+ ++
Sbjct:  430 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSSTGVRS--VTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEY 564
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968])

HSP 1 Score: 98.5969 bits (244), Expect = 3.336e-21
Identity = 53/140 (37.86%), Postives = 84/140 (60.00%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            EQ  L I  E MPGGS++ QL +   L   V  +Y +QIL+G+ ++H   I+HR+I   ++L D  GNVKL +F  SK +  +   M   GIK   +      ++PEV+ GE YG +AD+WS   T++E++T++ P+ ++
Sbjct:  430 EQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC--MSGTGIK--TVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEY 565
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 106.686 bits (265), Expect = 1.424e-24
Identity = 58/141 (41.13%), Postives = 85/141 (60.28%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNL-STDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +Q  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ F+H   I+HR+I   ++L D  GNVKL +F  SK L  + S     + + GT        ++PEV+ GE YG +ADIWS G T++E++T + P+ +F
Sbjct:  432 QQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGT-----PYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPWAEF 567
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: stk39 (serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GENE-140106-194])

HSP 1 Score: 86.2705 bits (212), Expect = 1.264e-18
Identity = 53/178 (29.78%), Postives = 90/178 (50.56%), Query Frame = 1 
Query: 1063 LEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLY---NLSTDMIFKGIKGTRIDDDACCVAPEVLLG-EPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXX-------XXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            LE  VI    +++LEGL ++H    IHR++  G++LL   G +++++F  S FL    +++ + + K   GT      C +APEV+     Y F+ADIWSFG T +E+ +   PY K+   + +           +    D E     G +F ++I +C+    + RPT + L+   F
Sbjct:    2 LEEPVIASILKEVLEGLDYLHRNGQIHRDVKAGNILLGEDGTIQIADFGVSAFLATGGDVTRNKVRKTFVGT-----PCWMAPEVMEQVRGYDFKADIWSFGITAMELASGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMVKKYGKSFRKLISQCLQKDPAKRPTAAELLKSKF 174
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 82.4185 bits (202), Expect = 5.347e-17
Identity = 61/196 (31.12%), Postives = 93/196 (47.45%), Query Frame = 1 
Query:  982 YTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNIN--CGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            Y +   L+I+ E + GGS    +   PLE   I    ++IL+GL ++H E+ IHR+I     +VLL  +G+VKL++F  +  L +         IK          +APEV+    Y F+ADIWS G T IE+   E P  +      +++I K      E +      F E +D C++     RPT   L+   F
Sbjct:   91 YLKGTKLWIIMEYLGGGSALDLIKPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQ-------IKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLEGNYSKA--FKEFVDSCLNKDPQFRPTAKELLKHKF 277
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008193.1 (pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-1 gene:ENSPMAG00000007385.1 transcript:ENSPMAT00000008193.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 80.8777 bits (198), Expect = 1.070e-16
Identity = 56/180 (31.11%), Postives = 86/180 (47.78%), Query Frame = 1 
Query:  859 CVAYAYDYKLTDINSMKILKYE-IVTRLKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
             V    + K TDI  +  L++  I+T   +    P   ++  Y  Q  L+ V        LR    I+P    +++ + + I  G+ ++H  KIIHR++   +VL+     VK+S+F  SK +   ST M F G            +APEV+  EP   + DIWSFG  L E++T E PY
Sbjct:   39 AVKKVREQKETDIKHLHKLRHPNIITFKGVCTHAPCYCIIMEYCAQGQLYEV--------LRAGRRISP---ELLVGWTRGIARGMSYLHLHKIIHRDLKSPNVLITHDDEVKISDFGTSKEMREKSTRMSFAGT--------VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 199
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399])

HSP 1 Score: 78.9518 bits (193), Expect = 1.254e-16
Identity = 46/155 (29.68%), Postives = 84/155 (54.19%), Query Frame = 1 
Query:  937 LKLSYKYPFV-ELLTMYTEQDNLFIVTEDMPGGSLRQQLSI-APLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            L L++ +P++  L + +  +++L  V E + GG L   + +    E      Y  +I+ GL+F+HD+ II+R++   ++LLD  G+VK+++F   K   N+  D+      GT        +APE+++G+ Y    D WSFG  L E++  + P+
Sbjct:   41 LSLAWGHPYLAHLYSTFQTKEHLMFVMEYLNGGDLMFHIQVKGRFEIDRATFYAAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCK--ENIVGDVRAGTFCGT-----PDYIAPEIVIGQKYNCSVDWWSFGVLLYEMLIGQSPF 188
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 91.6633 bits (226), Expect = 7.700e-20
Identity = 53/145 (36.55%), Postives = 82/145 (56.55%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQLS-IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEA 1419
            E  NL I  E +PGGS+   L+   P E S+I  + +QIL G+ ++H + IIHR+I   ++L+D KG VK+++F  SK L  L+     K  K   +      ++PEV+       +ADIWS G  +IE+ T + P+P F+  +A
Sbjct:  525 EGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNK----KQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQA 665
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 85.1149 bits (209), Expect = 1.085e-17
Identity = 48/149 (32.21%), Postives = 83/149 (55.70%), Query Frame = 1 
Query:  952 KYP-FVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            K+P  V  +  Y  + +L+++ E M GGSL   ++   L    I   C++ L GL+F+H + ++HR+I   ++LL  +G++KL++F F   +  L+       +K T +      +APEV+  + YG + DIWS G  +IE++  E PY
Sbjct:  673 KHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELN-------LKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPY 814
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061])

HSP 1 Score: 77.7962 bits (190), Expect = 1.071e-15
Identity = 48/151 (31.79%), Postives = 76/151 (50.33%), Query Frame = 1 
Query:  964 VELLTMYTEQ--DNLFIVTEDMPGGSLRQQLS-----IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            V+   M+T++   +++I  E M G SL             +   VI K  + +L GL ++H+ K+IHR+I   ++LL+ KG +KL +F  S    N S  M F G         +  +APE + G+PY    D+WS G TL+E+     P+
Sbjct:  274 VQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVN-SLAMTFTGT--------SFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPF 415
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242])

HSP 1 Score: 77.7962 bits (190), Expect = 2.133e-15
Identity = 51/142 (35.92%), Postives = 74/142 (52.11%), Query Frame = 1 
Query:  994 DNLFIVTEDMPGGSLRQQL--------SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            D+L++V E M GGSL   +        S +PL    I    ++  +GLKF+HD+ IIHR+I   +VLLD +  VK+++F F   L    TD   K  K   +      +APEV+    Y  + D+WS G   IE++  E PY
Sbjct:  634 DDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARL----TD---KRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPY 768
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 76.2554 bits (186), Expect = 6.210e-15
Identity = 56/193 (29.02%), Postives = 89/193 (46.11%), Query Frame = 1 
Query: 1000 LFIVTEDMPGGSLRQQLSIAP--LEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNS 1572
            L+I+ E    GSLR+ +S +   L  +    Y  Q L GLK++H E +IHR+I   ++LL     VKL++F  S  +   S+ +   G            +APE+L        +DIWS GAT++E++T+  PY   T  +A      +    Y    ++     + + KC       RPT   L+   + NS
Sbjct:   95 LYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVN--SSALTLAGTLN--------WMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLT--DANIYYAVENDTYYPPSSFSEP-LKDFLSKCFVKNMYKRPTADQLLKHVWINS 274
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 105.916 bits (263), Expect = 1.292e-25
Identity = 60/170 (35.29%), Postives = 99/170 (58.24%), Query Frame = 1 
Query:  898 NSMKILKYEIVTRLKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            N +K L+ EI   +K       V+   + T+  +++I  E +PGGS+ + +     L  S+  KY +QILEG+ ++H  +I+HR+I   ++L D  GNVKL++F  SK L  + +   F+ + GT        +APEV+ GE YG +AD+WS G T++E++T + P+  F
Sbjct:   46 NEVKALEGEI-EFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGFRSVHGT-----PYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADF 209
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO27976 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7S3])

HSP 1 Score: 91.2781 bits (225), Expect = 1.742e-20
Identity = 48/142 (33.80%), Postives = 85/142 (59.86%), Query Frame = 1 
Query:  976 TMYTEQDNLFIVTEDMPGGSLRQQLS-IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKG-NVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            T +T   N+F+  E M GGS+   LS   P E +++I+Y +QIL+G+ ++H+ +++HR+I   ++L+D  G ++++++F  +     L+T +   G    ++      +APEVL GE YG   D+WS G  LIE+ T + P+
Sbjct:  109 TRHTGHFNIFL--EWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAA---RLATQITGAGEFQGQLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPW 245
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1])

HSP 1 Score: 89.7373 bits (221), Expect = 7.593e-20
Identity = 53/151 (35.10%), Postives = 81/151 (53.64%), Query Frame = 1 
Query:  955 YPFVELLTMYTEQ---DNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMI-FKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            YP   ++ MY      D L++V E + GG+L   ++   L    +   C+ +L+ L F+H + +IHR+I   S+LL   G VKLS+F F      ++ DM   K + GT        +APEV+  +PYG + DIWS G  ++E+V  E PY
Sbjct:   81 YPHPNIVEMYGSHLVGDELWVVMEFLEGGTLTDIVTHTNLSEEQVACVCRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDFGFCA---QVTEDMPRRKSLVGT-----PYWMAPEVISRKPYGTEVDIWSLGIMVLEMVDGEPPY 223
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33129 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST31])

HSP 1 Score: 90.5077 bits (223), Expect = 2.660e-19
Identity = 72/269 (26.77%), Postives = 132/269 (49.07%), Query Frame = 1 
Query:  850 IEKCVAYAYDYKLTDINSMKILKYEIVTRLKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSL----RQQLSIAP-------LEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGF--QADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTN---------FDEIIDKCISSIQSNRPTVSFLIDD-YFKNSN*QDW 1587
            +EKC A + D  + +I++M    +E V           V   T +  +  L+IV   + GGS+    +Q++   P       LE  +I    +++L+GL++ H   +IHR++  G++LL   G+V+L++F  S  + +   D     ++ T +    C +APEV+  + +G+  +ADIWSFG T IE+ T   PY KF   + + +  +      E  C  G+          F +++  C+    +NRP  + L+ + +FK +  +D+
Sbjct:   49 LEKCGA-SIDEMMKEIHAMSQCNHENV-----------VNYYTSFVVRQELWIVMRLLNGGSMLDVIKQRIKQQPGLVDEGVLEEDIIATVLREVLKGLEYFHKNGLIHRDVKAGNILLATDGSVQLADFGVSSAISDYG-DRTKPKMRKTFVGT-PCWMAPEVMEQQVHGYNHKADIWSFGITAIELATGTAPYAKFPAMKVLMLTLQNDPPRMET-CADGSTRDYKKYSKVFKKMVSLCLQKEPANRPDANELLKNPFFKKAKGKDY 302
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2])

HSP 1 Score: 89.3521 bits (220), Expect = 1.323e-18
Identity = 53/161 (32.92%), Postives = 94/161 (58.39%), Query Frame = 1 
Query:  925 IVTRLKLSYKYPFVELL--TMYTEQDNLFIVTEDMPGGSLRQQLS-IAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKG-NVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPY 1395
            I+ RLK  +    ++ L  T +T   N+F+  E M GGS+   LS   P E +++I+Y +QIL+G+ ++H+ +++HR+I   ++L+D  G ++++++F  +     L+T +   G    ++      +APEVL GE YG   D+WS G  LIE+ T + P+
Sbjct:  631 ILARLKHPH---LIKCLGATRHTGHFNIFL--EWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAA---RLATQITGAGEFQGQLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPW 783
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 103.99 bits (258), Expect = 6.854e-23
Identity = 56/142 (39.44%), Postives = 85/142 (59.86%), Query Frame = 1 
Query:  985 TEQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLS-TDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            T +  L I  E MPGGS++ QL S   L  +V  +Y +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  S+ L  +  +    K + GT        ++PEV+ GE YG +ADIWS G T++E++T+  P+ +F
Sbjct:  461 TMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGIKSVTGT-----PYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEF 597
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 103.219 bits (256), Expect = 8.661e-23
Identity = 54/139 (38.85%), Postives = 84/139 (60.43%), Query Frame = 1 
Query:  991 QDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +  L I  E MPGGS++ QL +   L  +V  KY +QILEG+ ++H   I+HR+I   ++L D  GNVKL +F  SK L  +   M   GI+   +      ++PEV+ GE YG +AD+WS G T++E++T + P+ ++
Sbjct:  427 EKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGIRS--VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 561
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 99.3673 bits (246), Expect = 1.610e-21
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +Q  L I  E MPGGS++ QL +   L   V  +Y +QIL+G+ ++H   I+HR+I   ++L D  GNVKL +F  SK +  +   M   GIK   +      ++PEV+ GE YG +AD+WS   T++E++T++ P+ ++
Sbjct:  400 DQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC--MSGTGIKS--VTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEY 535
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 99.3673 bits (246), Expect = 1.897e-21
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +Q  L I  E MPGGS++ QL +   L   V  +Y +QIL+G+ ++H   I+HR+I   ++L D  GNVKL +F  SK +  +   M   GIK   +      ++PEV+ GE YG +AD+WS   T++E++T++ P+ ++
Sbjct:  430 DQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC--MSGTGIKS--VTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEY 565
[Close]
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 99.3673 bits (246), Expect = 1.897e-21
Identity = 52/140 (37.14%), Postives = 84/140 (60.00%), Query Frame = 1 
Query:  988 EQDNLFIVTEDMPGGSLRQQL-SIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKF 1404
            +Q  L I  E MPGGS++ QL +   L   V  +Y +QIL+G+ ++H   I+HR+I   ++L D  GNVKL +F  SK +  +   M   GIK   +      ++PEV+ GE YG +AD+WS   T++E++T++ P+ ++
Sbjct:  430 DQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTIC--MSGTGIKS--VTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEY 565
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000014613.1 (SMESG000014613.1)

HSP 1 Score: 977.237 bits (2525), Expect = 0.000e+0
Identity = 487/511 (95.30%), Postives = 495/511 (96.87%), Query Frame = 1 
Query:   43 MARYLIKLTDLVTQNSVNTFEILQSDNVVYLKVKLSGKIGGRAQDFQIHSTDSVNNPLNDNRSISDISFTGNLFYTISKEQSDDIILYVKRNYCGIPKFLQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLQQCEFDNSKVKIWAGESLIVNITLLNPLNTEDENVTQVIGRFEFSATETVASLKEFILNENRQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVDMSKRTDIIINTADKTKEKYYARYPGTINSSVIEKCVAYAYDYKLTDINSMKILKYEIVTRLKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYFKNSN 1575
            MARYLIKLTDL TQNSVNTFEILQSDNVVYLKVKLS KIGGRAQDFQIHSTDSVNNPLNDNRSISDISF GNLFYTISKEQSDDIILYVKRNYCGIPKFLQFPKLTTIGQLISELKTLYNIQKNFYI Q NGSFADNNATL+QC+FDNSKVKIW GE+ IVNITLLNPLNTED+NV   IGRFEFSATETVASLKEFILNEN+QFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVDMSKRTDIIINTADKTKEKYYARYPGTINSSVIEKCVAYAYD KLTDINSMKILKYEIVTRLKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIF GIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPK TYK+AIYII  +KKIDYER+CYAGTNFDEIIDKCIS IQSNRPTVSFLIDDYFKNSN
Sbjct:    1 MARYLIKLTDLFTQNSVNTFEILQSDNVVYLKVKLSDKIGGRAQDFQIHSTDSVNNPLNDNRSISDISFAGNLFYTISKEQSDDIILYVKRNYCGIPKFLQFPKLTTIGQLISELKTLYNIQKNFYIFQENGSFADNNATLEQCKFDNSKVKIWVGENYIVNITLLNPLNTEDKNV---IGRFEFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVDMSKRTDIIINTADKTKEKYYARYPGTINSSVIEKCVAYAYDCKLTDINSMKILKYEIVTRLKLSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFMGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKLTYKKAIYIIKNEKKIDYERNCYAGTNFDEIIDKCISPIQSNRPTVSFLIDDYFKNSN 508
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000014619.1 (SMESG000014619.1)

HSP 1 Score: 603.979 bits (1556), Expect = 0.000e+0
Identity = 314/506 (62.06%), Postives = 383/506 (75.69%), Query Frame = 1 
Query:   55 LIKLTDLVTQNSVNTFEILQSDNVVYLKVKLSGKIGGRAQDFQIHSTDSVN-NPLNDNRSISDISFTGNLFYTISKEQSDDIILYVKRNYCGIPKFLQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLQQCEFDNSKVKIWAGESLIVNITLLNPLNTEDENVTQVIGRFEFSATETVASLKEFILNENRQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVDMSKRTDIIINTADKTKEKYYARYPGTINSSVIEKCVAYAYDYKLTDINSMKILKYEIVTRLKLSYK--YPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTVSFLIDDYF 1563
            +I L ++   N + TFE+L SDN++YLK KL+ +I  R QD ++    ++   PLN+N  I        L+Y+I +E++DDIIL++KRNYCGIPKF QFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATL+QC+FDNSKVKIW GESLIVNITLLNPLNTEDENVTQVIGRF+FSATETVASLKEFILNEN+QFHNLQLFTETSFLDDKKQLASYPLDRECKIYCV+MS + ++ I +   T  K+   Y G IN S    C    Y   ++D N+ K  KYE++TRLKL Y    PFVEL+ MYTE + L IVTE M GGSL+ +LS A L  + I KYC+QIL+GL+F+H EKIIHRNINC SVL+DG GN KL+NF+ SKFL+N +TDM+  GI G+++DDD CCVAPEVLLGEPYGF+AD+WSFGA LI+IV+ +RPYP     +A  +I + + I YE      + +D II +CI  IQ +RP    L +D+ 
Sbjct:    3 VITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQRNIAVPPLNNNGRIP----CKELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLEQCKFDNSKVKIWVGESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTG-KFADIYLGKIN-SFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLS-ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEP---IISGYDAIIARCIRPIQKHRPNAWELHNDFL 498
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000014940.1 (SMESG000014940.1)

HSP 1 Score: 236.113 bits (601), Expect = 1.432e-70
Identity = 164/482 (34.02%), Postives = 247/482 (51.24%), Query Frame = 1 
Query:  118 DNVVYLKVKLSGKIGGRAQDFQIHSTDSVNNPLNDNRSI-SDISFTGNLFYTISKEQSDDIILYVKRNYCGIPKFLQFPKLTTIGQLISELKTLYNIQ-KNFYILQGNGSFADNNATLQQCEFDNSKVKIWAGESLIVNITLLNPLNTEDENVTQVIGRFEFSATETVASLKEFI---LNENRQFHNLQLFTETSFLDDKKQLASYPLDRE-CKIYCVDMSKRTDIIINTADKTKEKYYARYPGTINSSVIEKCVAYAYDYKLTDINSMKILKYEIVTRLKLSYK--YPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTV 1539
            DN V +K ++S  I        + +       LNDN  I S+I     +FY +S+  ++ I++ + +N+  IPK++Q     T+ QL   L +      K F   +      DN A       + SK+K+W G  L+V + + +PL  +    TQ     E S TE++ +LK+ I   ++  ++   L LFTETSFL D K L  YP+ RE C+IY  D+ K      N      E  YAR          E+     Y  +   +    IL+YEIVTR+ LS      F EL+ MY +    +IVT+ M  GSL+   +   L    II+Y  QI E L +MH  ++IHR+++C SVL+    N+KLSNF  S++L+  +T  + +GI G++I+     +APEVL  +PYG ++DIWSFG T++E++TR+RPYP        + I   K I+Y ++        E IDKC+   Q  RPT 
Sbjct:   26 DNAVIIKKRISDLINIEVHKINLFAERW--QRLNDNDFIDSNIKL---IFYEVSQPITEKIVVQMMKNHFNIPKWIQVKTEATVLQLKKILSSFSESHLKTFLFTEAGEMLLDNTAIKSYDLMNASKLKVWRGNDLLVQLEICDPLAKDPS--TQKRFPLEISVTESIINLKKKISEKISIGKEI-KLALFTETSFLQDGKCLLDYPIPRENCQIYYADLIKEE--TANIKGPLAEGRYARIFEGEFGQFNERVAIKRYKIEERRVEDANILRYEIVTRIMLSKANVSRFAELMAMYDDSKYFYIVTDFMEQGSLKDIYTARQLNDHEIIRYSIQISEALDYMHSNRLIHRDLSCSSVLVGSDNNIKLSNFQLSEYLF--TTAQLLEGIPGSKIESQQLWLAPEVLHKKPYGIKSDIWSFGVTVMEMLTRDRPYPNMNIVSGSHKICNNKCIEYNKN--ISPKISEFIDKCLHECQCERPTA 493
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000014940.1 (SMESG000014940.1)

HSP 1 Score: 162.925 bits (411), Expect = 1.063e-45
Identity = 89/231 (38.53%), Postives = 132/231 (57.14%), Query Frame = 1 
Query:  853 EKCVAYAYDYKLTDINSMKILKYEIVTRLKLSYK--YPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTV 1539
            E+     Y  +   +    IL+YEIVTR+ LS      F EL+ MY +    +IVT+ M  GSL+   +   L    II+Y  QI E L +MH  ++IHR+++C SVL+    N+KLSNF  S++L+  +T  + +GI G++I+     +APEVL  +PYG ++DIWSFG T++E++TR+RPYP        + I   K I+Y ++        E IDKC+   Q  RPT 
Sbjct:   39 ERVAIKRYKIEERRVEDANILRYEIVTRIMLSKANVSRFAELMAMYDDSKYFYIVTDFMEQGSLKDIYTARQLNDHEIIRYSIQISEALDYMHSNRLIHRDLSCSSVLVGSDNNIKLSNFQLSEYLF--TTAQLLEGIPGSKIESQQLWLAPEVLHKKPYGIKSDIWSFGVTVMEMLTRDRPYPNMNIVSGSHKICNNKCIEYNKNI--SPKISEFIDKCLHECQCERPTA 265
[Close]
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000014940.1 (SMESG000014940.1)

HSP 1 Score: 162.925 bits (411), Expect = 1.237e-45
Identity = 89/231 (38.53%), Postives = 132/231 (57.14%), Query Frame = 1 
Query:  853 EKCVAYAYDYKLTDINSMKILKYEIVTRLKLSYK--YPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKFTYKEAXXXXXXXXXXDYERDCYAGTNFDEIIDKCISSIQSNRPTV 1539
            E+     Y  +   +    IL+YEIVTR+ LS      F EL+ MY +    +IVT+ M  GSL+   +   L    II+Y  QI E L +MH  ++IHR+++C SVL+    N+KLSNF  S++L+  +T  + +GI G++I+     +APEVL  +PYG ++DIWSFG T++E++TR+RPYP        + I   K I+Y ++        E IDKC+   Q  RPT 
Sbjct:   50 ERVAIKRYKIEERRVEDANILRYEIVTRIMLSKANVSRFAELMAMYDDSKYFYIVTDFMEQGSLKDIYTARQLNDHEIIRYSIQISEALDYMHSNRLIHRDLSCSSVLVGSDNNIKLSNFQLSEYLF--TTAQLLEGIPGSKIESQQLWLAPEVLHKKPYGIKSDIWSFGVTVMEMLTRDRPYPNMNIVSGSHKICNNKCIEYNKNI--SPKISEFIDKCLHECQCERPTA 276
The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K37.306e-2339.42mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K37.901e-2339.42mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K38.039e-2339.42mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K38.046e-2339.42mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K38.046e-2339.42mitogen-activated protein kinase kinase kinase 3 [... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pak-27.855e-1932.28Serine/threonine-protein kinase pak-2 [Source:Uni... [more]
pak-27.916e-1932.28Serine/threonine-protein kinase pak-2 [Source:Uni... [more]
F26E4.51.167e-1733.55Tyrosine-protein kinase [Source:UniProtKB/TrEMBL;... [more]
pak-11.610e-1734.48Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
pak-11.857e-1734.48Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Slik3.773e-1831.36gene:FBgn0035001 transcript:FBtr0100470[more]
Slik4.363e-1831.36gene:FBgn0035001 transcript:FBtr0072363[more]
Slik4.438e-1831.36gene:FBgn0035001 transcript:FBtr0332925[more]
Slik4.178e-1730.88gene:FBgn0035001 transcript:FBtr0072366[more]
Slik4.178e-1730.88gene:FBgn0035001 transcript:FBtr0072364[more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k33.889e-2338.85mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k33.926e-2338.85mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k34.949e-2338.85mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k25.083e-2340.14mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k26.207e-2340.14mitogen-activated protein kinase kinase kinase 2 [... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K21.317e-2239.44mitogen-activated protein kinase kinase kinase 2 [... [more]
MAP3K21.766e-2239.44mitogen-activated protein kinase kinase kinase 2 [... [more]
samd82.874e-2238.13sterile alpha motif domain containing 8 [Source:Xe... [more]
samd83.540e-2238.13sterile alpha motif domain containing 8 [Source:Xe... [more]
dennd1a2.718e-2037.50DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map3k32.835e-2340.44mitogen-activated protein kinase kinase kinase 3 [... [more]
Map3k25.488e-2238.30mitogen-activated protein kinase kinase kinase 2 [... [more]
Stk256.397e-1936.50serine/threonine kinase 25 (yeast) [Source:MGI Sym... [more]
Stk399.500e-1928.70serine/threonine kinase 39 [Source:MGI Symbol;Acc:... [more]
Stk252.334e-1831.44serine/threonine kinase 25 (yeast) [Source:MGI Sym... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O22040|ANP1_ARATH4.230e-2432.92Mitogen-activated protein kinase kinase kinase ANP... [more]
sp|Q61084|M3K3_MOUSE1.983e-2240.44Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q99759|M3K3_HUMAN3.509e-2239.42Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q9Y2U5|M3K2_HUMAN2.272e-2139.01Mitogen-activated protein kinase kinase kinase 2 O... [more]
sp|Q9FZ36|M3K2_ARATH1.527e-2032.13Mitogen-activated protein kinase kinase kinase 2 O... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3K2F31.893e-2433.33mitogen-activated protein kinase kinase kinase 3 i... [more]
A0A2P6QMP91.973e-2434.80Putative mitogen-activated protein kinase kinase k... [more]
A0A1S3K1D92.031e-2433.33mitogen-activated protein kinase kinase kinase 3 i... [more]
A0A0L8HR142.385e-2438.62Protein kinase domain-containing protein OS=Octopu... [more]
A0A453KRF34.767e-2340.41Protein kinase domain-containing protein OS=Aegilo... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k21.760e-2240.14mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k32.626e-2237.41mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k32.626e-2237.41mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k32.626e-2237.41mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k223.336e-2137.86mitogen-activated protein kinase kinase kinase 3-l... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k21.424e-2441.13mitogen-activated protein kinase kinase kinase 2 [... [more]
stk391.264e-1829.78serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GE... [more]
stk25a5.347e-1731.12serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
ENSPMAT00000008193.11.070e-1631.11pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-... [more]
PRKCD1.254e-1629.68protein kinase C delta [Source:HGNC Symbol;Acc:HGN... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
STE117.700e-2036.55Signal transducing MEK kinase; involved in pheromo... [more]
STE201.085e-1732.21Cdc42p-activated signal transducing kinase; involv... [more]
MKK21.071e-1531.79MAPKK involved in the protein kinase C signaling p... [more]
CLA42.133e-1535.92Cdc42p-activated signal transducing kinase; member... [more]
CDC156.210e-1529.02Protein kinase of the Mitotic Exit Network; locali... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414101.292e-2535.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO279761.742e-2033.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458467.593e-2035.10Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO331292.660e-1926.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361501.323e-1832.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k26.854e-2339.44mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k38.661e-2338.85mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.610e-2137.14mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.897e-2137.14mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.897e-2137.14mitogen-activated protein kinase kinase kinase 3 [... [more]
back to top
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000014613.10.000e+095.30SMESG000014613.1[more]
SMESG000014619.10.000e+062.06SMESG000014619.1[more]
SMESG000014940.11.432e-7034.02SMESG000014940.1[more]
SMESG000014940.11.063e-4538.53SMESG000014940.1[more]
SMESG000014940.11.237e-4538.53SMESG000014940.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30026298 ID=SMED30026298|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1730bp
CTAATATTTGTTTAAATAATTATCGATGATGATGATTTGAATATGGCAAG
GTATTTAATAAAGCTAACAGATCTTGTCACACAAAATAGTGTGAATACGT
TTGAAATTCTTCAAAGTGACAATGTCGTTTATTTGAAGGTGAAATTGTCT
GGCAAAATTGGTGGAAGAGCACAAGATTTTCAAATTCATTCAACAGATTC
TGTGAATAATCCATTAAACGATAACAGATCAATTTCTGATATTTCATTCA
CTGGGAATTTATTTTATACAATTTCCAAAGAACAATCTGACGACATAATT
CTCTACGTTAAGCGCAATTATTGCGGCATTCCGAAGTTTTTGCAATTTCC
GAAACTTACTACAATCGGCCAATTAATTTCGGAATTGAAAACATTATATA
ATATTCAAAAGAATTTCTATATATTGCAAGGAAATGGCTCGTTTGCTGAC
AATAATGCGACATTGCAGCAATGCGAATTCGACAATTCGAAGGTCAAAAT
ATGGGCGGGTGAAAGTTTAATTGTCAACATTACCCTTCTGAATCCACTGA
ACACAGAGGATGAAAATGTCACTCAAGTTATTGGTAGATTTGAATTCTCA
GCTACGGAAACGGTTGCTAGTTTAAAGGAATTTATTCTAAATGAAAATAG
ACAATTTCATAATTTACAACTGTTTACAGAAACATCATTTTTAGACGATA
AGAAGCAATTAGCAAGCTATCCGCTTGACAGAGAGTGCAAAATCTATTGT
GTAGATATGTCGAAGAGAACTGATATAATTATAAATACTGCTGATAAAAC
AAAAGAAAAATATTATGCAAGATATCCTGGTACAATAAATTCCTCTGTAA
TTGAAAAGTGTGTTGCATATGCATATGATTACAAGCTGACCGATATCAAC
AGCATGAAAATATTAAAATATGAAATCGTAACTCGCCTTAAGTTATCGTA
TAAATATCCGTTTGTTGAACTTTTGACTATGTATACGGAGCAGGACAATC
TTTTCATAGTTACGGAGGATATGCCTGGAGGATCGCTGAGACAGCAACTG
AGTATTGCACCATTGGAAGCGTCGGTAATCATCAAGTATTGTCAGCAAAT
ACTTGAAGGGCTAAAGTTCATGCATGACGAAAAAATTATTCACAGGAACA
TTAACTGCGGAAGTGTTCTTCTCGATGGAAAGGGAAATGTGAAACTCTCA
AACTTTCACTTTTCTAAATTCCTTTATAATCTATCAACAGACATGATATT
CAAGGGCATTAAAGGCACCAGAATTGATGATGACGCCTGTTGTGTTGCAC
CAGAAGTGCTGCTTGGTGAACCCTATGGATTTCAAGCTGACATATGGTCA
TTTGGAGCGACGCTTATTGAGATCGTTACTCGTGAACGGCCTTATCCAAA
GTTTACTTATAAGGAAGCTATTTATATAATAGGAAAAAAAAAAAAAATTG
ATTATGAGCGAGATTGTTACGCCGGCACAAATTTTGATGAAATAATTGAC
AAGTGCATCAGTTCAATACAATCGAACAGACCAACCGTTTCATTCTTGAT
TGATGATTATTTTAAGAATTCCAATTGACAAGATTGGTCTAAAACCTTTC
TTTGATTGAAGCTTCTTTTTTTATTTCTATCCAACTACTACTGCATGATA
TTCTATTTTAGTGTATTTTTTGAATTTAATTTTCGGTTGTTGTATTTTTT
AGTATACTTTATTCAAGCAGTTCACTCCCG
back to top

protein sequence of SMED30026298-orf-1

>SMED30026298-orf-1 ID=SMED30026298-orf-1|Name=SMED30026298-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=512bp
MARYLIKLTDLVTQNSVNTFEILQSDNVVYLKVKLSGKIGGRAQDFQIHS
TDSVNNPLNDNRSISDISFTGNLFYTISKEQSDDIILYVKRNYCGIPKFL
QFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLQQCEFDNSK
VKIWAGESLIVNITLLNPLNTEDENVTQVIGRFEFSATETVASLKEFILN
ENRQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVDMSKRTDIIINTA
DKTKEKYYARYPGTINSSVIEKCVAYAYDYKLTDINSMKILKYEIVTRLK
LSYKYPFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYC
QQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTD
MIFKGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERP
YPKFTYKEAIYIIGKKKKIDYERDCYAGTNFDEIIDKCISSIQSNRPTVS
FLIDDYFKNSN*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000418head
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR011009Kinase-like_dom_sf
IPR029071Ubiquitin-like_domsf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0004702signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0005515protein binding
GO:0016301kinase activity
GO:0016740transferase activity
GO:0042803protein homodimerization activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0006915apoptotic process
GO:0007163establishment or maintenance of cell polarity
GO:0016310phosphorylation
GO:0023014signal transduction by protein phosphorylation
GO:0032874positive regulation of stress-activated MAPK cascade
GO:0036481intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:0042542response to hydrogen peroxide
GO:0046777protein autophosphorylation
GO:0050772positive regulation of axonogenesis
GO:0051645Golgi localization
GO:0051683establishment of Golgi localization
GO:0090168Golgi reassembly
Vocabulary: cellular component
TermDefinition
GO:0000139Golgi membrane
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0070062extracellular exosome
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 266..507
e-value: 8.4E-42
score: 145.1
NoneNo IPR availablePANTHERPTHR45832FAMILY NOT NAMEDcoord: 299..500
NoneNo IPR availableCDDcd17039Ubl_ubiquitin_likecoord: 179..234
e-value: 0.00565521
score: 33.7238
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 291..500
e-value: 3.9E-30
score: 105.1
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 171..504
score: 25.474
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 281..505
IPR029071Ubiquitin-like domain superfamilySUPERFAMILYSSF54236Ubiquitin-likecoord: 179..234