delta(24)-sterol reductase

Overview
Namedelta(24)-sterol reductase
Smed IDSMED30026195
Length (bp)1796
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of delta(24)-sterol reductase (SMED30026195) t-SNE clustered cells

Violin plots show distribution of expression levels for delta(24)-sterol reductase (SMED30026195) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of delta(24)-sterol reductase (SMED30026195) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for delta(24)-sterol reductase (SMED30026195) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30026195

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
reproductive organSMED30026195SMESG000076611.1 Contig50154newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30026195SMESG000076611.1 Contig50154uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30026195SMESG000076611.1 Contig42597newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30026195SMESG000076611.1 Contig42597uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Human
Match: DHCR24 (24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859])

HSP 1 Score: 595.504 bits (1534), Expect = 0.000e+0
Identity = 283/514 (55.06%), Postives = 376/514 (73.15%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ +  KF  E+ +  +N FVE L++S D  V+MTG M+ + +  K +NSIG++YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +Q +L  F  ++ ++P+WLCPF L   PGLV P  +++E                 +Y+DIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+REK   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQ-ENHFVEGLLYSLDEAVIMTGVMTDEAEPSK-LNSIGNYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAE-----------------LYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Human
Match: DHCR24 (24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859])

HSP 1 Score: 595.504 bits (1534), Expect = 0.000e+0
Identity = 283/514 (55.06%), Postives = 376/514 (73.15%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ +  KF  E+ +  +N FVE L++S D  V+MTG M+ + +  K +NSIG++YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +Q +L  F  ++ ++P+WLCPF L   PGLV P  +++E                 +Y+DIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+REK   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQ-ENHFVEGLLYSLDEAVIMTGVMTDEAEPSK-LNSIGNYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAE-----------------LYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Human
Match: DHCR24 (24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859])

HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0
Identity = 283/526 (53.80%), Postives = 376/526 (71.48%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQ------------DIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ +  KF  E+ +  +N FVE L++S D  V+MTG M+ + +  K +NSIG++YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+Q            DIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +Q +L  F  ++ ++P+WLCPF L   PGLV P  +++E                 +Y+DIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+REK   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQ-ENHFVEGLLYSLDEAVIMTGVMTDEAEPSK-LNSIGNYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQLLCFSVSDVPQRDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAE-----------------LYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH 528
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Human
Match: DHCR24 (24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859])

HSP 1 Score: 184.882 bits (468), Expect = 8.845e-55
Identity = 84/131 (64.12%), Postives = 103/131 (78.63%), Query Frame = 3 
Query:  294 QIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTEN 686
            Q+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN
Sbjct:   36 QVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSEN 166
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Human
Match: DHCR24 (24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859])

HSP 1 Score: 177.948 bits (450), Expect = 7.079e-53
Identity = 80/122 (65.57%), Postives = 98/122 (80.33%), Query Frame = 3 
Query:  333 LCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLF 698
            +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN DLF
Sbjct:    1 MCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLF 122
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Celegans
Match: F52H2.6 (Diminuto-like protein [Source:UniProtKB/Swiss-Prot;Acc:O17397])

HSP 1 Score: 484.952 bits (1247), Expect = 1.789e-166
Identity = 247/529 (46.69%), Postives = 344/529 (65.03%), Query Frame = 3 
Query:  123 QRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYIN-LIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSP---------TENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDN-EFVEALVFSPDSGVVMTGNMSCKPKNKKQI-NSIGSFYKPWFFKHVE-FIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDAR 1670
            ++ + + + ++RW+FV+ FLLPLS L+N + + R+RI+  +NSAP  H  +VK+IQ+Q++ W  +G K+KL  ARPGW TMSFR   YK N+ KI  + L D+L ++ EK  V+ EP VTM QLS  L+  G+T+PV+PELDDLTVGGLI G G+E+ S K+G+FQHIC   ++V+ DGEL    P          ++  LF+A  WS GTI FLV+A IKII  K Y+K+ Y    ++ ++ E+   ++ +  +N +FVEAL+F+ + G +M G  S  P    ++ N IG +YK WF+ HVE  I K+  S+  E+IP+RDYYHRHS+SIFWE++DI+PFGNN +FR+L  W  PPKI+ LK T   V++K+Y+ SHVLQDMLVP+  +++ +  F+KEV I+P+WLCPF L   PGL++                   N  + MYVD+G YGV     Y    TTR LE+FVR V GFQM YAD YMTR E+ +MF+ +LYD  R       AFP+IYDKI +  R
Sbjct:   15 EKCVEFIMFHFRWVFVVPFLLPLSFLFNTVFDFRNRIVHAVNSAPNAHVRKVKHIQEQLKEWNDNGRKSKLVNARPGWLTMSFRFPLYKENATKIATDKLFDILDLDVEKMTVKAEPGVTMGQLSQYLISRGYTLPVLPELDDLTVGGLINGCGVESGSFKYGMFQHICTGYEVVMSDGELKNVYPDSAAKTEQAKQDNSLFFAIPWSQGTICFLVAATIKIIPCKKYVKLTYKKTETLSEMCEQLTEDSDRNSENVDFVEALMFNKEKGCIMLGEFSDGPDTHDEVVNPIGRWYKKWFYTHVEDLINKKHESI--EYIPLRDYYHRHSKSIFWELRDIVPFGNNVLFRYLMAWMCPPKIAFLKATTPNVLRKLYDRSHVLQDMLVPLDKLEECIDLFHKEVEIYPMWLCPFYLKSQPGLMKLR-----------------NATHKMYVDVGAYGVTSKDGYHHERTTRRLESFVRSVNGFQMTYADIYMTRAEYAEMFDRTLYDWKRASCKCIDAFPDIYDKICRSGR 524
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Celegans
Match: Y7A5A.1 (pep chromosome:WBcel235:X:15767437:15771509:-1 gene:WBGene00012407.1 transcript:Y7A5A.1.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y7A5A.1)

HSP 1 Score: 343.969 bits (881), Expect = 2.985e-111
Identity = 185/518 (35.71%), Postives = 301/518 (58.11%), Query Frame = 3 
Query:  156 RWIFVLIFLLPLSVLYNILSNIR---DRIIFYLNSAPKFHETRVKNIQKQIRTWW-MSGSKTK-LCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPT-ENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDN----EFVEALVFSPDSGVVMTGNMS-CKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVP-KVSTYDAFNTT---RNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKD 1664
            R + +++F LP S L+++    R   DR +    SA   H+ RV+ IQ Q+  W  +  S+ K LCTARP W ++S      K   H++ I+L DVL ++E+   V VEP +T++++   L+P G+T+ V  E+ D T+GGL  G G+ T SHK GL+Q   +  ++V  DG +IT + + E+ DLFY   WSHGT+GFLV   ++I++ K Y+ ++Y PCHS D+  +K    +     N    +++E  ++  +  V+M GN +    K+  ++N +  FYKPWF+KHVE  +K+      E+IP+  Y  RH+R+IFW ++ +IPFGN+ +FR   GW  PPK + LK T  + +++M     V QD+++P+  +++ +    K    +PL + P R++   G       ++    ++    N     Y M+ D+GVYG P +V   + +N T   R +E F R VGG+  LYAD +M+ +EF +MF+ +LY++VR +YH + AFP +YDK+  +
Sbjct:   18 RGLVIVLFCLPASFLFDLFIQFRIWLDRKL----SATTSHQQRVQKIQDQVTEWSKLPDSEQKPLCTARPNWLSLSTTFFD-KRKCHQVPIDLHDVLSLDEKNLTVTVEPNITVREICKFLIPKGYTLAVTLEIGDATLGGLAFGVGMTTYSHKVGLYQEAIVSYEVVTADGNVITVTDSNEHSDLFYCLPWSHGTLGFLVGLTLRIVKVKPYVHMEYIPCHSQDEYCKKIMELSGATDKNTKVADYLEVTIYDKNEAVIMVGNFADVDSKSNAKVNDVCWFYKPWFYKHVETFLKKGGE---EYIPLESYLLRHNRAIFWVVESMIPFGNHPVFRAFLGWLCPPKPAFLKFTTTQAVREMTFAKQVFQDIVMPLDTLKEQVDTAVKLFDTYPLLVYPCRIYDHKGGAPQGQLRAPPKSRLVPGTN-----YSMFNDLGVYGTPGQVERREPYNPTHAMRAMEKFTRDVGGYSFLYADIFMSEEEFNEMFDMTLYNQVRLRYHCDGAFPRLYDKVKPE 522
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Celegans
Match: Y7A5A.1 (pep chromosome:WBcel235:X:15767437:15771493:-1 gene:WBGene00012407.1 transcript:Y7A5A.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y7A5A.1)

HSP 1 Score: 343.969 bits (881), Expect = 2.985e-111
Identity = 185/518 (35.71%), Postives = 301/518 (58.11%), Query Frame = 3 
Query:  156 RWIFVLIFLLPLSVLYNILSNIR---DRIIFYLNSAPKFHETRVKNIQKQIRTWW-MSGSKTK-LCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPT-ENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDN----EFVEALVFSPDSGVVMTGNMS-CKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVP-KVSTYDAFNTT---RNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKD 1664
            R + +++F LP S L+++    R   DR +    SA   H+ RV+ IQ Q+  W  +  S+ K LCTARP W ++S      K   H++ I+L DVL ++E+   V VEP +T++++   L+P G+T+ V  E+ D T+GGL  G G+ T SHK GL+Q   +  ++V  DG +IT + + E+ DLFY   WSHGT+GFLV   ++I++ K Y+ ++Y PCHS D+  +K    +     N    +++E  ++  +  V+M GN +    K+  ++N +  FYKPWF+KHVE  +K+      E+IP+  Y  RH+R+IFW ++ +IPFGN+ +FR   GW  PPK + LK T  + +++M     V QD+++P+  +++ +    K    +PL + P R++   G       ++    ++    N     Y M+ D+GVYG P +V   + +N T   R +E F R VGG+  LYAD +M+ +EF +MF+ +LY++VR +YH + AFP +YDK+  +
Sbjct:   18 RGLVIVLFCLPASFLFDLFIQFRIWLDRKL----SATTSHQQRVQKIQDQVTEWSKLPDSEQKPLCTARPNWLSLSTTFFD-KRKCHQVPIDLHDVLSLDEKNLTVTVEPNITVREICKFLIPKGYTLAVTLEIGDATLGGLAFGVGMTTYSHKVGLYQEAIVSYEVVTADGNVITVTDSNEHSDLFYCLPWSHGTLGFLVGLTLRIVKVKPYVHMEYIPCHSQDEYCKKIMELSGATDKNTKVADYLEVTIYDKNEAVIMVGNFADVDSKSNAKVNDVCWFYKPWFYKHVETFLKKGGE---EYIPLESYLLRHNRAIFWVVESMIPFGNHPVFRAFLGWLCPPKPAFLKFTTTQAVREMTFAKQVFQDIVMPLDTLKEQVDTAVKLFDTYPLLVYPCRIYDHKGGAPQGQLRAPPKSRLVPGTN-----YSMFNDLGVYGTPGQVERREPYNPTHAMRAMEKFTRDVGGYSFLYADIFMSEEEFNEMFDMTLYNQVRLRYHCDGAFPRLYDKVKPE 522
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Zebrafish
Match: dhcr24 (24-dehydrocholesterol reductase [Source:ZFIN;Acc:ZDB-GENE-041212-73])

HSP 1 Score: 583.563 bits (1503), Expect = 0.000e+0
Identity = 279/514 (54.28%), Postives = 372/514 (72.37%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L Y I++ RWIFV +FLLPLSV++++  ++R  IIF + SAPK H+ RV++IQ+Q+R W   G K  +CT RPGW T+S RVGKYK     I IN++D+L V+ ++K VRVEPL  M Q++A L  +GWT+PV+PELDDLTVGGL+MGTGIE+SSH +GLFQHIC+  +LVL DG L+ C+  EN DLFYA  WS GT+GFLV+A+I+II A+ ++K+ Y P   +D + +KF  E+    +N+FVE L +S D  V+MTG M+   +  K  N IG +YKPWFF+HVE  +KQ   V  E+IP+R YYHRH+RSIFWE+QDIIPFGNN +FR++FGW VPPKISLLKLTQGE I+K+YE  HV+QDMLVP++ I+ ++  F++++ ++PLWLCPF L   PG+V P  D+ E                 +YVDIG YG PKV  ++A ++TR LE FVR V GFQMLYAD YM RKEF +MF+ +LY K+RE+   + AFPE++DKI K AR+
Sbjct:   23 LEYVIIHQRWIFVCLFLLPLSVVFDVYYHLRAWIIFKMCSAPKQHDQRVRDIQRQVREWRKDGGKKYMCTGRPGWLTVSLRVGKYKKTHKNIMINMMDILEVDTKQKVVRVEPLANMGQVTALLNSIGWTLPVLPELDDLTVGGLVMGTGIESSSHIYGLFQHICVAFELVLADGSLVRCTEKENSDLFYAVPWSCGTLGFLVAAEIRIIPAQKWVKLHYEPVRGLDAICKKFAEESANK-ENQFVEGLQYSRDEAVIMTGVMTDHAEPDK-TNCIGYYYKPWFFRHVESFLKQN-RVAVEYIPLRHYYHRHTRSIFWELQDIIPFGNNPLFRYVFGWMVPPKISLLKLTQGETIRKLYEQHHVVQDMLVPMKDIKAAIQRFHEDIHVYPLWLCPFLLPNQPGMVHPKGDEDE-----------------LYVDIGAYGEPKVKHFEATSSTRQLEKFVRDVHGFQMLYADVYMERKEFWEMFDGTLYHKLREELGCKDAFPEVFDKICKSARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Zebrafish
Match: dhcr24 (24-dehydrocholesterol reductase [Source:ZFIN;Acc:ZDB-GENE-041212-73])

HSP 1 Score: 369.392 bits (947), Expect = 4.629e-123
Identity = 174/321 (54.21%), Postives = 234/321 (72.90%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQ 1094
            L Y I++ RWIFV +FLLPLSV++++  ++R  IIF + SAPK H+ RV++IQ+Q+R W   G K  +CT RPGW T+S RVGKYK     I IN++D+L V+ ++K VRVEPL  M Q++A L  +GWT+PV+PELDDLTVGGL+MGTGIE+SSH +GLFQHIC+  +LVL DG L+ C+  EN DLFYA  WS GT+GFLV+A+I+II A+ ++K+ Y P   +D + +KF  E+    +N+FVE L +S D  V+MTG M+   +  K  N IG +YKPWFF+HVE  +KQ   V  E+IP+R YYHRH+RSIFWE+Q
Sbjct:   23 LEYVIIHQRWIFVCLFLLPLSVVFDVYYHLRAWIIFKMCSAPKQHDQRVRDIQRQVREWRKDGGKKYMCTGRPGWLTVSLRVGKYKKTHKNIMINMMDILEVDTKQKVVRVEPLANMGQVTALLNSIGWTLPVLPELDDLTVGGLVMGTGIESSSHIYGLFQHICVAFELVLADGSLVRCTEKENSDLFYAVPWSCGTLGFLVAAEIRIIPAQKWVKLHYEPVRGLDAICKKFAEESANK-ENQFVEGLQYSRDEAVIMTGVMTDHAEPDKT-NCIGYYYKPWFFRHVESFLKQN-RVAVEYIPLRHYYHRHTRSIFWELQ 340
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Xenopus
Match: dhcr24 (24-dehydrocholesterol reductase [Source:NCBI gene;Acc:549554])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 278/514 (54.09%), Postives = 367/514 (71.40%), Query Frame = 3 
Query:  138 YFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQ--DIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            Y IV++RWIFV +FLLPLSV++++    R  ++F + SAPK H+ RVK+IQ Q+R W   G K  +CT RPGW T+S RVGKYK+    I INL+D+L V+ +++ VRVEPLV M Q++A L  + WT+PV+PELDDL +GGLIMGTGIE+SSH  GLFQHIC+  +LVL DG L+ C+PTEN DLFYA  WS GT+GFLV+A+IKI+ AK Y+K+ Y P   ++ + EKF  E+ K  +N FVE LV+S D  V+MTG ++       Q+N IG ++KPWFF+HVE  +K      TE+IP+R YYHRH++SIFWE+Q  DIIPFGN+ +FR+ FGW VPPKISLLKLTQGE I+K+YE  HV+QDMLVP++ +Q ++  F+ E+S++PLWLCPF L   PG++ P  +++E                 +YVDIG YG PK   +DA  + R LE FVR V GFQMLYAD YM+R+EF DMF+ +LY K+R K +   AFPE+YDKI K AR+
Sbjct:   25 YVIVHHRWIFVCLFLLPLSVIFDVYYYARAWLVFKMCSAPKQHDRRVKDIQDQVRQWKAEGGKNFMCTGRPGWLTVSLRVGKYKNTHKNIMINLMDILEVDTKRQPVRVEPLVNMGQVTALLNSISWTLPVVPELDDLKIGGLIMGTGIESSSHNFGLFQHICLAYELVLADGSLVRCTPTENSDLFYAVPWSCGTLGFLVAAEIKIVPAKKYVKLHYTPVKGLEKICEKFSRES-KNKENYFVEGLVYSADEAVIMTGVLT-DEAQAGQVNRIGQYWKPWFFRHVESYLKNNRDG-TEYIPLRHYYHRHTKSIFWELQVHDIIPFGNHPVFRYFFGWMVPPKISLLKLTQGETIRKLYEQHHVVQDMLVPMKCLQKAITAFHSEISVYPLWLCPFILPSHPGMIHPKGNEAE-----------------LYVDIGAYGEPKTKHFDAKGSMRRLEKFVRDVHGFQMLYADCYMSREEFWDMFDGALYQKLRGKLNCNNAFPEVYDKICKAARH 518
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Xenopus
Match: txlnb (taxilin beta [Source:Xenbase;Acc:XB-GENE-876994])

HSP 1 Score: 57.3806 bits (137), Expect = 3.768e-8
Identity = 33/114 (28.95%), Postives = 58/114 (50.88%), Query Frame = 3 
Query:  426 VLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRA 767
            +L V++EKK V VE  + +  L+  L   G  +  +  + ++   G+I GTG   +   HG+     + L L+   GE++ CS   N ++F AA    G++G ++S  I+   A
Sbjct:   75 ILKVDKEKKQVTVEGGMLLTDLNKELDKRGLALSNLGAVSEVAAAGVI-GTGTHNTGITHGILATQVVALALMTASGEILECSEATNPEIFQAARLHLGSLGVILSVTIQCRSA 187
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Xenopus
Match: txlnb (taxilin beta [Source:Xenbase;Acc:XB-GENE-876994])

HSP 1 Score: 56.9954 bits (136), Expect = 4.525e-8
Identity = 33/114 (28.95%), Postives = 58/114 (50.88%), Query Frame = 3 
Query:  426 VLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRA 767
            +L V++EKK V VE  + +  L+  L   G  +  +  + ++   G+I GTG   +   HG+     + L L+   GE++ CS   N ++F AA    G++G ++S  I+   A
Sbjct:   75 ILKVDKEKKQVTVEGGMLLTDLNKELDKRGLALSNLGAVSEVAAAGVI-GTGTHNTGITHGILATQVVALALMTASGEILECSEATNPEIFQAARLHLGSLGVILSVTIQCRSA 187
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Xenopus
Match: txlnb (taxilin beta [Source:Xenbase;Acc:XB-GENE-876994])

HSP 1 Score: 56.9954 bits (136), Expect = 4.614e-8
Identity = 33/114 (28.95%), Postives = 58/114 (50.88%), Query Frame = 3 
Query:  426 VLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRA 767
            +L V++EKK V VE  + +  L+  L   G  +  +  + ++   G+I GTG   +   HG+     + L L+   GE++ CS   N ++F AA    G++G ++S  I+   A
Sbjct:   75 ILKVDKEKKQVTVEGGMLLTDLNKELDKRGLALSNLGAVSEVAAAGVI-GTGTHNTGITHGILATQVVALALMTASGEILECSEATNPEIFQAARLHLGSLGVILSVTIQCRSA 187
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Mouse
Match: Dhcr24 (24-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1922004])

HSP 1 Score: 592.423 bits (1526), Expect = 0.000e+0
Identity = 282/514 (54.86%), Postives = 375/514 (72.96%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLV+M Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +L+L DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ + EKF  E+ +  +N FVE L++S D  V+MTG M+   +  K +NSIGS+YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +  +L  F  ++ ++P+WLCPF L   PGLV P  D++E                 +YVDIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+R++   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTRESQR-LENHFVEGLLYSLDEAVIMTGVMTDDVEPSK-LNSIGSYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCMSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAE-----------------LYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Mouse
Match: Gulo (gulonolactone (L-) oxidase [Source:MGI Symbol;Acc:MGI:1353434])

HSP 1 Score: 64.6994 bits (156), Expect = 1.631e-10
Identity = 36/112 (32.14%), Postives = 61/112 (54.46%), Query Frame = 3 
Query:  426 VLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKII 761
            VL V++EKK V VE  + +  L   L   G  +  +  + D+TVGG+I G+G   +  KHG+     + L L+  DG ++ CS + N D+F AA    G +G +++  ++ +
Sbjct:   75 VLQVDKEKKQVTVEAGILLTDLHPQLDKHGLALSNLGAVSDVTVGGVI-GSGTHNTGIKHGILATQVVALTLMKADGTVLECSESSNADVFQAARVHLGCLGVILTVTLQCV 185
[Close]
BLAST of delta(24)-sterol reductase vs. UniProt/SwissProt
Match: sp|Q15392|DHC24_HUMAN (Delta(24)-sterol reductase OS=Homo sapiens OX=9606 GN=DHCR24 PE=1 SV=2)

HSP 1 Score: 595.504 bits (1534), Expect = 0.000e+0
Identity = 283/514 (55.06%), Postives = 376/514 (73.15%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ +  KF  E+ +  +N FVE L++S D  V+MTG M+ + +  K +NSIG++YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +Q +L  F  ++ ++P+WLCPF L   PGLV P  +++E                 +Y+DIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+REK   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQ-ENHFVEGLLYSLDEAVIMTGVMTDEAEPSK-LNSIGNYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAE-----------------LYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. UniProt/SwissProt
Match: sp|Q60HC5|DHC24_MACFA (Delta(24)-sterol reductase OS=Macaca fascicularis OX=9541 GN=DHCR24 PE=2 SV=2)

HSP 1 Score: 594.734 bits (1532), Expect = 0.000e+0
Identity = 283/514 (55.06%), Postives = 376/514 (73.15%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLVTM Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +LVL DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ +  KF  E+ +  +N FVE L++S D  V+MTG M+ + +  K +NSIG++YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +Q +L  F  ++ ++P+WLCPF L   PGLV P  +++E                 +Y+DIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+REK   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVQGLEAICAKFTHESQRQ-ENHFVEGLLYSLDEAVIMTGVMTDEVEPSK-LNSIGNYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAE-----------------LYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. UniProt/SwissProt
Match: sp|Q5BQE6|DHC24_RAT (Delta(24)-sterol reductase OS=Rattus norvegicus OX=10116 GN=Dhcr24 PE=2 SV=2)

HSP 1 Score: 592.423 bits (1526), Expect = 0.000e+0
Identity = 282/514 (54.86%), Postives = 375/514 (72.96%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLV+M Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +L+L DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ + EKF  E+ +  +N FVE L++S D  V+MTG M+   +  K +NSIGS+YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +  +L  F  ++ ++P+WLCPF L   PGLV P  D++E                 +YVDIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+R++   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVQDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTHESQR-LENHFVEGLLYSLDEAVIMTGVMTDDVEPSK-LNSIGSYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAE-----------------LYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. UniProt/SwissProt
Match: sp|Q8VCH6|DHC24_MOUSE (Delta(24)-sterol reductase OS=Mus musculus OX=10090 GN=Dhcr24 PE=1 SV=1)

HSP 1 Score: 592.423 bits (1526), Expect = 0.000e+0
Identity = 282/514 (54.86%), Postives = 375/514 (72.96%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +++ RW+FV +FLLPLS++++I   +R  ++F L+SAP+ HE RV++IQKQ+R W   GSKT +CT RPGW T+S RVGKYK     I INL+D+L V+ +K+ VRVEPLV+M Q++A L  +GWT+PV+PELDDLTVGGLIMGTGIE+SSHK+GLFQHIC   +L+L DG  + C+P+EN DLFYA  WS GT+GFLV+A+I+II AK Y+K+ + P   ++ + EKF  E+ +  +N FVE L++S D  V+MTG M+   +  K +NSIGS+YKPWFFKHVE  +K       E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+LFGW VPPKISLLKLTQGE ++K+YE  HV+QDMLVP++ +  +L  F  ++ ++P+WLCPF L   PGLV P  D++E                 +YVDIG YG P+V  ++A +  R LE FVR V GFQMLYAD YM R+EF +MF+ SLY K+R++   + AFPE+YDKI K AR+
Sbjct:   23 LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTRESQR-LENHFVEGLLYSLDEAVIMTGVMTDDVEPSK-LNSIGSYYKPWFFKHVENYLKTNREGL-EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCMSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAE-----------------LYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH 516
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BLAST of delta(24)-sterol reductase vs. UniProt/SwissProt
Match: sp|O17397|DIML_CAEEL (Diminuto-like protein OS=Caenorhabditis elegans OX=6239 GN=F52H2.6 PE=3 SV=1)

HSP 1 Score: 484.952 bits (1247), Expect = 2.276e-165
Identity = 247/529 (46.69%), Postives = 344/529 (65.03%), Query Frame = 3 
Query:  123 QRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYIN-LIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSP---------TENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDN-EFVEALVFSPDSGVVMTGNMSCKPKNKKQI-NSIGSFYKPWFFKHVE-FIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDAR 1670
            ++ + + + ++RW+FV+ FLLPLS L+N + + R+RI+  +NSAP  H  +VK+IQ+Q++ W  +G K+KL  ARPGW TMSFR   YK N+ KI  + L D+L ++ EK  V+ EP VTM QLS  L+  G+T+PV+PELDDLTVGGLI G G+E+ S K+G+FQHIC   ++V+ DGEL    P          ++  LF+A  WS GTI FLV+A IKII  K Y+K+ Y    ++ ++ E+   ++ +  +N +FVEAL+F+ + G +M G  S  P    ++ N IG +YK WF+ HVE  I K+  S+  E+IP+RDYYHRHS+SIFWE++DI+PFGNN +FR+L  W  PPKI+ LK T   V++K+Y+ SHVLQDMLVP+  +++ +  F+KEV I+P+WLCPF L   PGL++                   N  + MYVD+G YGV     Y    TTR LE+FVR V GFQM YAD YMTR E+ +MF+ +LYD  R       AFP+IYDKI +  R
Sbjct:   15 EKCVEFIMFHFRWVFVVPFLLPLSFLFNTVFDFRNRIVHAVNSAPNAHVRKVKHIQEQLKEWNDNGRKSKLVNARPGWLTMSFRFPLYKENATKIATDKLFDILDLDVEKMTVKAEPGVTMGQLSQYLISRGYTLPVLPELDDLTVGGLINGCGVESGSFKYGMFQHICTGYEVVMSDGELKNVYPDSAAKTEQAKQDNSLFFAIPWSQGTICFLVAATIKIIPCKKYVKLTYKKTETLSEMCEQLTEDSDRNSENVDFVEALMFNKEKGCIMLGEFSDGPDTHDEVVNPIGRWYKKWFYTHVEDLINKKHESI--EYIPLRDYYHRHSKSIFWELRDIVPFGNNVLFRYLMAWMCPPKIAFLKATTPNVLRKLYDRSHVLQDMLVPLDKLEECIDLFHKEVEIYPMWLCPFYLKSQPGLMKLR-----------------NATHKMYVDVGAYGVTSKDGYHHERTTRRLESFVRSVNGFQMTYADIYMTRAEYAEMFDRTLYDWKRASCKCIDAFPDIYDKICRSGR 524
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BLAST of delta(24)-sterol reductase vs. TrEMBL
Match: A0A1S3JWJ9 (delta(24)-sterol reductase OS=Lingula unguis OX=7574 GN=LOC106176554 PE=4 SV=1)

HSP 1 Score: 632.869 bits (1631), Expect = 0.000e+0
Identity = 300/522 (57.47%), Postives = 391/522 (74.90%), Query Frame = 3 
Query:  114 SWHQ-RLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNE-EKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            SW + R L Y ++NYRW+FV  FLLP+SV+Y++   +R+ I+F LNSAPK H+ +V+++Q+Q++ W   G +T++CTARPGW T+SFR G YK     I +NLID+L V+   ++ VRVEPL TM Q++ATL PLGWT+PV+PELDDLTVGGLIMG GIETSSHK+GLFQH C+  +LVL DG ++ CS  EN DLFYA  WS+GT+GFLVSADIKII AK Y++++Y P HS ++++  F+ ET K   NEFVE L++S +  V+MTGNM+    + K INSIG+F+KPWFFKHVE  ++    V  E+IP+R YYHRH+RSIFWE+QDIIPFGN+ +FR+LFGW VPPKISLLKLTQGE IK+MYE   ++QDMLVP+  +  +L  F+KEV ++PLWLCPF L  LPG+V P  DK                   MYVDIG YG PKV+ +D   TTRN+E FVR+V GFQMLYAD+YMTR+EFR+MF+H+LYDK+R + + + AFPE+YDK++K AR 
Sbjct:   17 SWAKFRGLEYILINYRWVFVCFFLLPISVIYDVFYFVRNWIVFKLNSAPKLHDKKVQDVQRQVKQWASDGCQTQMCTARPGWMTVSFRQGLYKRTMRNINVNLIDILEVDTTNRQVVRVEPLATMGQITATLNPLGWTLPVLPELDDLTVGGLIMGVGIETSSHKYGLFQHCCVAFELVLADGSVVKCSKDENPDLFYAVPWSYGTLGFLVSADIKIIPAKKYLRMEYKPVHSFNEILRVFEEETKKKTGNEFVEGLMYSENEAVIMTGNMTNDAPSDK-INSIGNFWKPWFFKHVEGFLRTGPGV--EYIPLRHYYHRHTRSIFWELQDIIPFGNHPVFRYLFGWMVPPKISLLKLTQGETIKRMYEQHQMIQDMLVPMADLGSALKCFHKEVKLYPLWLCPFYLPNLPGMVHPKGDKD-----------------AMYVDIGAYGEPKVNNFDPVKTTRNIEEFVRKVQGFQMLYADSYMTREEFREMFDHTLYDKMRGQLNCKKAFPEVYDKVNKKART 518
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BLAST of delta(24)-sterol reductase vs. TrEMBL
Match: A0A210QJU8 (Delta(24)-sterol reductase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT08722 PE=4 SV=1)

HSP 1 Score: 624.009 bits (1608), Expect = 0.000e+0
Identity = 291/512 (56.84%), Postives = 387/512 (75.59%), Query Frame = 3 
Query:  126 RLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISK 1661
            R L Y I NYRW+FV +FLLP+SV+Y+     R+ I+F +NSAPK H+ +VK++Q+Q++ W   G   ++CTARPGW T+SFR G YK +S KI +NL+D+L ++   + VRVEPLV+M Q+SA L PL WT+PV+PELDDLTVGGLIMG GIETSSHKHGLFQH C+  +LVL DG L+TCS T N++LFYA  WS+GT+GFLVSA++KII AK++++++Y P ++ DD++E F+ ETMK  DN+FVE LV+S ++ V+MTGN++ +    K IN IG F+KPWFFKHVE  +K+   V  E+IPIR YYHRH+RSIFWE+QDIIPFGN+ +FR+LFGW+VPPKISLLKLTQGE  K+MYE   ++QDMLVP+  ++++L  F++E+ ++PLWLCPF+LF  PG+V P  +  E                 MYVDIG YG PK   +DA  +TR LEA+V +V GFQMLYADTY+TR+EFR MF+H+LYD +R+    E AFPE+YDKI++
Sbjct:   28 RGLEYVIKNYRWVFVCLFLLPMSVVYDFYMYFRNWIVFQMNSAPKQHDKKVKDVQRQVKEWVSDGCTKQMCTARPGWMTISFRQGLYKQSSRKIKVNLVDILEIDSANQTVRVEPLVSMGQISAFLNPLDWTLPVLPELDDLTVGGLIMGVGIETSSHKHGLFQHCCVGYELVLADGTLVTCSATHNKELFYAVPWSYGTLGFLVSAELKIIPAKTFVRMEYRPVYTTDDMIETFEKETMKKRDNQFVEGLVYSNNTAVIMTGNLTDEADFDK-INPIGYFWKPWFFKHVEDFLKKGPDV--EYIPIRHYYHRHTRSIFWELQDIIPFGNHPVFRYLFGWSVPPKISLLKLTQGETTKRMYEKYQIIQDMLVPMTSLKEALGVFHEEIKMYPLWLCPFKLFNNPGMVHPKGNADE-----------------MYVDIGAYGSPKAINFDAIPSTRRLEAYVTKVNGFQMLYADTYLTREEFRKMFDHTLYDVMRDTLDCERAFPEVYDKINR 519
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BLAST of delta(24)-sterol reductase vs. TrEMBL
Match: A0A267ECF4 (FAD-binding PCMH-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig024933g3 PE=4 SV=1)

HSP 1 Score: 622.083 bits (1603), Expect = 0.000e+0
Identity = 299/531 (56.31%), Postives = 392/531 (73.82%), Query Frame = 3 
Query:   84 MEPLKYFKNNSWHQRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKY-HSEAAFPEIYDKISKDARN 1673
            M+P+   +N    ++L AY +VNYRW+FVL+FLLPLS+LY+    +R++IIF L SAP+ H+ RVK++Q+QI  W  SG + KLCTARPGW+ MSFR GKYK   + + +NLID+L VN   + VR EP+V+M QL+ATLLPLGWTIP++PELDDLTVGGL+MGTG+ETSSH HGLFQHIC   +LVL DG ++TCS TEN DLFYA  WS+GT+GFLVSA I++I A S++++ Y PCHS+++L + F  E+ K  +N+FVE LV+S +SGVVM G  S    +  +IN IG ++KPWFFKHVE  +K    V  EFIP R YYHRHSRSIFW++QDI+PFGN+ IFR+L GWAVPPK+SL+KLTQGE +KKMYE   ++QDMLVPI  +  ++  F++E++++PLWLCPF L   PG+++P  D+S+                 MYVDIG YG PK   Y A  TTR LEA+VR V GFQMLYADT+MT  EF  MF+H LYD++R+K   ++ AFP +YDKI++ AR+
Sbjct:    1 MDPMAGLENAPMSEKLFAYILVNYRWVFVLLFLLPLSLLYDAFFYVRNKIIFRLRSAPRQHDARVKDVQRQITAWAASGGRQKLCTARPGWQNMSFRRGKYKKTHYNVNVNLIDILEVNPNSRTVRCEPMVSMGQLTATLLPLGWTIPIVPELDDLTVGGLVMGTGVETSSHAHGLFQHICESYELVLADGSVVTCSATENSDLFYAVPWSYGTLGFLVSATIRLIPAHSFVRLTYIPCHSLEELSKTFADESAKREENDFVEGLVYSAESGVVMVGK-STNQADPDRINRIGDYWKPWFFKHVEQFLKTGGGV--EFIPTRHYYHRHSRSIFWQMQDIVPFGNHPIFRYLLGWAVPPKVSLMKLTQGETVKKMYETHQIIQDMLVPITDLAGAIKVFHREINMYPLWLCPFYLPDNPGMLRPRDDRSQ-----------------MYVDIGAYGAPKNPEYKAEATTRRLEAYVREVRGFQMLYADTFMTESEFEAMFDHRLYDRLRDKLARTKDAFPRVYDKINRSARD 511
[Close]
BLAST of delta(24)-sterol reductase vs. TrEMBL
Match: A0A267GHJ0 (FAD-binding PCMH-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig024933g1 PE=4 SV=1)

HSP 1 Score: 622.083 bits (1603), Expect = 0.000e+0
Identity = 299/531 (56.31%), Postives = 392/531 (73.82%), Query Frame = 3 
Query:   84 MEPLKYFKNNSWHQRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKY-HSEAAFPEIYDKISKDARN 1673
            M+P+   +N    ++L AY +VNYRW+FVL+FLLPLS+LY+    +R++IIF L SAP+ H+ RVK++Q+QI  W  SG + KLCTARPGW+ MSFR GKYK   + + +NLID+L VN   + VR EP+V+M QL+ATLLPLGWTIP++PELDDLTVGGL+MGTG+ETSSH HGLFQHIC   +LVL DG ++TCS TEN DLFYA  WS+GT+GFLVSA I++I A S++++ Y PCHS+++L + F  E+ K  +N+FVE LV+S +SGVVM G  S    +  +IN IG ++KPWFFKHVE  +K    V  EFIP R YYHRHSRSIFW++QDI+PFGN+ IFR+L GWAVPPK+SL+KLTQGE +KKMYE   ++QDMLVPI  +  ++  F++E++++PLWLCPF L   PG+++P  D+S+                 MYVDIG YG PK   Y A  TTR LEA+VR V GFQMLYADT+MT  EF  MF+H LYD++R+K   ++ AFP +YDKI++ AR+
Sbjct:    1 MDPMAGLENAPMSEKLFAYILVNYRWVFVLLFLLPLSLLYDAFFYVRNKIIFRLRSAPRQHDARVKDVQRQITAWAASGGRQKLCTARPGWQNMSFRRGKYKKTHYNVNVNLIDILEVNPNSRTVRCEPMVSMGQLTATLLPLGWTIPIVPELDDLTVGGLVMGTGVETSSHAHGLFQHICESYELVLADGSVVTCSATENSDLFYAVPWSYGTLGFLVSATIRLIPAHSFVRLTYIPCHSLEELSKTFADESAKREENDFVEGLVYSAESGVVMVGK-STNQADPDRINRIGDYWKPWFFKHVERFLKTGGGV--EFIPTRHYYHRHSRSIFWQMQDIVPFGNHPIFRYLLGWAVPPKVSLMKLTQGETVKKMYETHQIIQDMLVPITDLAGAIKVFHREINMYPLWLCPFYLPDNPGMLRPRDDRSQ-----------------MYVDIGAYGAPKNPEYKAEATTRRLEAYVREVRGFQMLYADTFMTESEFEAMFDHRLYDRLRDKLARTKDAFPRVYDKINRSARD 511
[Close]
BLAST of delta(24)-sterol reductase vs. TrEMBL
Match: V4BLP6 (FAD-binding PCMH-type domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_125011 PE=4 SV=1)

HSP 1 Score: 620.542 bits (1599), Expect = 0.000e+0
Identity = 292/521 (56.05%), Postives = 383/521 (73.51%), Query Frame = 3 
Query:  114 SWHQ-RLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            SW + R L Y +++YRW+FV +FLLP SV+Y+ +  +R+ ++F+ NSAPK HE +V+N+Q+Q+R W   GS   +CTARPGW  +SFR G YK     I +NL+D+L V+ EK+ + VEPL TM Q++A L PLGWT+PV+PELDDLTVGGLIMG GIETSSHK GLFQH C E +LVL DG ++TCS TEN DLFY+  WS+GT+GFLVSA +KI+ AK Y+K++Y P H+ D ++EKF+SE MK   N+FVE LV+S + GVVMT NM+ + +  K IN IG +YKPWFFKHVE  +K    +  E+IP+R YYHRH+RSIFWE+QDIIPFGNN IFR+L GW VPPKIS LKLTQGE IK+MYE   ++QDML+P++ +++SL  F+KE  ++PLWLCPF L+  PG+V P   + E                 MYVDIG YG P    Y+   TTR LEAFV +V GFQMLYAD+Y+TR+EF DMF+H+LY+K+R +   +AAFPE+YDK+++  R+
Sbjct:   20 SWIKYRGLEYVLIHYRWVFVCLFLLPASVVYDTIIFVRNWVVFHFNSAPKQHEKKVQNVQRQVRKWKNEGSVVPMCTARPGWSNISFRRGLYKKRLRNIEVNLLDILSVDIEKEILHVEPLATMGQITAFLNPLGWTLPVLPELDDLTVGGLIMGVGIETSSHKKGLFQHCCTEFELVLADGSVVTCSETENTDLFYSVPWSYGTLGFLVSAKMKIVPAKKYVKIEYAPVHTTDSMIEKFESECMKKEGNQFVECLVYSKNEGVVMTANMTDEAEEDK-INRIGYYYKPWFFKHVEGFLKSGPRI--EYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLCGWMVPPKISFLKLTQGETIKQMYEKYQIIQDMLIPMKNLKESLDVFHKETEVYPLWLCPFMLYDQPGMVHPAGGRDE-----------------MYVDIGAYGPPIAKGYETVTTTRKLEAFVTKVKGFQMLYADSYLTREEFYDMFDHTLYNKMRRELDCKAAFPEVYDKVNRKVRS 520
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Cavefish
Match: dhcr24 (24-dehydrocholesterol reductase [Source:ZFIN;Acc:ZDB-GENE-041212-73])

HSP 1 Score: 552.362 bits (1422), Expect = 0.000e+0
Identity = 268/514 (52.14%), Postives = 361/514 (70.23%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L Y I++ RWIFV +FLLPLSV++++   +R  IIF + SAPK H+ RV++IQ+Q+R W   G K  +CT RPGW T              I IN++D+L V+ +++ VRVEPL  M Q++A L  +GWT+PV+PELDDLTVGGL+MGTGIE+SSH +GLFQHIC+  +LVL DG L+ C+  EN DLFY+  WS GT+GFLV+A+I+II A+ ++K+ Y     +D++ + F  E+    +N+FVE L +S D  V+MTG M+   +  K IN IG +YKPWFFKHVE  +K +  V  E+IP+R YYHRH+RSIFWE+QDIIPFGNN +FR++FGW VPPKISLLKLTQGE I+++YE  HV+QDMLVP++ I+ +L  F++++ ++PLWLCPF L   PG+V P  ++ E                 +YVDIG YG PKV  ++A  +TR LE FVR V GFQMLYAD YM R EF +MF+ +LY K+R++   E AFPE+YDKI K AR+
Sbjct:   23 LDYVIIHQRWIFVCLFLLPLSVIFDVYYYVRAWIIFKMCSAPKLHDQRVRDIQRQVREWKKEGGKKHMCTGRPGWLT-------------NIMINMMDILQVDTKRQVVRVEPLANMGQVTALLNSIGWTLPVLPELDDLTVGGLVMGTGIESSSHIYGLFQHICVAYELVLADGSLVRCTEKENSDLFYSVPWSCGTLGFLVAAEIRIIPARKWVKLRYKAVRGLDNICKTFSEESANK-ENQFVEGLQYSLDEAVIMTGTMTDDAEPDK-INRIGYYYKPWFFKHVEQYLKDD-RVAVEYIPLRHYYHRHTRSIFWELQDIIPFGNNPLFRYVFGWMVPPKISLLKLTQGETIRRLYEQHHVVQDMLVPMKNIKMALTRFHQDIHVYPLWLCPFILPSQPGMVHPKGNEDE-----------------LYVDIGAYGEPKVKHFEAQASTRQLEKFVRDVHGFQMLYADVYMERPEFWEMFDGTLYHKLRKELGCEEAFPEVYDKICKAARH 503
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Sea Lamprey
Match: dhcr24 (24-dehydrocholesterol reductase [Source:ZFIN;Acc:ZDB-GENE-041212-73])

HSP 1 Score: 598.971 bits (1543), Expect = 0.000e+0
Identity = 281/516 (54.46%), Postives = 372/516 (72.09%), Query Frame = 3 
Query:  126 RLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            R L Y +V +RW+FV +FLLPLSVL++    IR  ++F + SAPK H+ RV++IQKQ+R W   G +T +CT RPGW T+S RVGKYK     I INL+D+L V+ +++ VRVEPLV M Q+++ L  +GWT+PV+PELDDLTVGGLIMGTGIETSSH +GLFQHIC+  +LVL DG L+ CS TEN DLFYA  WS+GT+GFLV+A+++I+ A+ Y+K+ Y P   +D +   FQ E  +P    FVE L++  +  V+MTG ++   +  K IN+IG ++KPWFFKHVE  + +      E+IP+R Y+HRH+RSIFWE+QDIIPFGN+ +FR L GW VPPKI+LLKLTQGEV++K+YE  HV+QDMLVP+  +Q SL  F+ E++++PLWLCPFRL  +PG+V P  D+ E                 MYVDIG YG PK+  Y A  TTR LE FVR   GFQMLYAD+YM+R+EF +MF+ +LY K+R++Y  E AFPE+YDKI K AR+
Sbjct:   21 RGLEYVLVQHRWLFVCLFLLPLSVLFDAYYFIRAWLVFRMCSAPKQHDQRVRDIQKQVRQWRAEGGQTYMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKRQIVRVEPLVNMGQVTSLLSSIGWTLPVVPELDDLTVGGLIMGTGIETSSHIYGLFQHICVSFELVLADGSLVRCSETENSDLFYAVPWSYGTLGFLVAAEVRIVPARHYVKLRYTPVRGLDAICSTFQHECTRPDPATFVEGLMYGRNEAVIMTGELTDTAEPDK-INNIGYYWKPWFFKHVEGFLHKSGPPCVEYIPLRHYHHRHTRSIFWELQDIIPFGNHPVFRMLLGWMVPPKIALLKLTQGEVVRKLYEQHHVVQDMLVPMHALQKSLTCFHDEINLYPLWLCPFRLPSVPGMVHPKSDQEE-----------------MYVDIGAYGEPKMKGYTAGTTTRRLEQFVRDQHGFQMLYADSYMSREEFWNMFDPTLYQKMRKQYGCEGAFPEVYDKICKAARH 518
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Yeast
Match: ALO1 (D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress [Source:SGD;Acc:S000004551])

HSP 1 Score: 50.447 bits (119), Expect = 5.073e-7
Identity = 33/102 (32.35%), Postives = 53/102 (51.96%), Query Frame = 3 
Query:  456 VRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKII 761
            V V+  + + QL+  L   G++I  +  + + +V G+I  TG   SS  HGL     + L +V   GEL       + ++F AA  S G IG +VSA I+++
Sbjct:   91 VTVDAGMRLYQLNEFLGAKGYSIQNLGSISEQSVAGII-STGSHGSSPYHGLISSQYVNLTIVNGKGELKFLDAENDPEVFKAALLSVGKIGIIVSATIRVV 191
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Nematostella
Match: EDO36241 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ62])

HSP 1 Score: 569.311 bits (1466), Expect = 0.000e+0
Identity = 284/519 (54.72%), Postives = 362/519 (69.75%), Query Frame = 3 
Query:  126 RLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVN----EEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDAR 1670
            R + + I++ RWIFV +FLLP+SVLY     +R+ + F   S P+ H+ RV+ +Q+Q++ W   G K  +CTARPGW T+S RVGKYK     I +NL+D+L +N    E    VRVEP+VTM QL+  L+PLGWTIPV+PELDDLTVGGLIMG GIE+SSHK GLFQHIC+   LVL DG L+  S  ENE LFY+  WSHGT+GFLV+A+I II AK Y+++ Y P HS  +L   F  E+M   +NEFVEAL +S    VVMTG    + +  K +N IG F+KPWFFKHV+  +K    V  E+IP+RDYYHRH+RSIFWE+QDIIPFGNN I+R+LFGW +PPKISLLKLTQGE ++++YE  HV+QDMLVPI  + +SL  F++   ++PLW+CP  L + PGLV    DK              +    MYVDIG YG PKV  + A    R +EAFV+ V GFQMLYAD+YMTR+EFR MF+H LYDK+RE+   + AFPEIYDK+S+ AR
Sbjct:   23 RGVEHIIIHQRWIFVCLFLLPVSVLYESFLFVRNWLAFKYYSDPERHKERVQKVQEQVQKWNKDGRKQPMCTARPGWMTVSPRVGKYKKTHCNIDVNLMDILEINCAAGESTGVVRVEPMVTMGQLTHALVPLGWTIPVLPELDDLTVGGLIMGCGIESSSHKFGLFQHICVGFDLVLADGTLVHASKKENEHLFYSIPWSHGTLGFLVAAEIIIIPAKKYVRLSYNPVHSKKELETSFTRESMSK-ENEFVEALAYSEIEAVVMTGTFEDEAEPDK-LNPIGYFWKPWFFKHVQSYLKSGPGV--EYIPLRDYYHRHTRSIFWELQDIIPFGNNVIWRYLFGWVMPPKISLLKLTQGETLRRLYEQHHVVQDMLVPIETLGNSLSCFHENFELYPLWICPMYLPRTPGLVHAPVDKRR-----------PHSDGRMYVDIGAYGTPKVKNFVARENMRRVEAFVKSVDGFQMLYADSYMTREEFRAMFDHELYDKLREEMQCKEAFPEIYDKVSRAAR 526
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Nematostella
Match: EDO44935 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU13])

HSP 1 Score: 53.1434 bits (126), Expect = 1.898e-7
Identity = 29/106 (27.36%), Postives = 55/106 (51.89%), Query Frame = 3 
Query:  426 VLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVS 743
            VL +++EK+ V ++  +T+ +L   L   G   P +  +  ++  G+I  T +  +   +GL       L ++   GE+ITCS   NED+F +     G++G ++S
Sbjct:   84 VLEIDQEKQQVTMQAGLTLTELHTVLDIHGLGFPNLGAVSGISCAGVI-STCVHGTGFNYGLLATHVSRLDIMTASGEIITCSRMHNEDIFRSVICGMGSVGVILS 188
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Medaka
Match: dhcr24 (24-dehydrocholesterol reductase [Source:NCBI gene;Acc:101172722])

HSP 1 Score: 565.074 bits (1455), Expect = 0.000e+0
Identity = 271/514 (52.72%), Postives = 364/514 (70.82%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +V+ RWIFV  FLLPLSV++++   +R  IIF + SAPK H+ RV+++Q+Q+R W   G+K+ +CT RPGW T+S RVGKYK     I IN++D+L V+ +++ V+VEPL  M Q++A L  +GWT+PV+PELDDLTVGGL+MGTGIE+SSH +GLFQHIC+  +LVL DG L+ CS  EN DLF+A  WS GT+GFLV+A+IKI+ AK ++K+   P   ++++  +F +E      N FVE L +S DS VVMTG M+   +  K IN IG  +KPWFFKHVE  +K E     E+IP+R YYHRH+RSIFWE+QDIIPFGNN +FR LFGW VPPKISLLKLTQGE I+++YE  HV+QDMLVP++++Q ++  F++++ ++PLWLCPF L    G+V P  D+ E                 +YVDIG YG PKV  ++A  +TR LE FVR   GFQMLYAD YM R+EF +MF+  LY ++RE+   + AFPE+Y KI K AR+
Sbjct:   23 LEHVLVHQRWIFVCAFLLPLSVIFDVYYYVRAWIIFKMCSAPKLHDQRVRDVQRQVREWRKDGAKSHMCTGRPGWLTVSLRVGKYKKTHKNILINMMDILEVDTKRQVVKVEPLANMGQVTALLNGMGWTLPVLPELDDLTVGGLVMGTGIESSSHIYGLFQHICVAYELVLADGSLVRCSEEENVDLFHAVPWSCGTLGFLVAAEIKIVPAKPWVKLRLEPVRGLENICRRF-AEASSNKQNTFVEGLQYSLDSAVVMTGTMTDHAEPDK-INRIGLHFKPWFFKHVEGYLK-EGRTGVEYIPLRQYYHRHTRSIFWELQDIIPFGNNPVFRWLFGWMVPPKISLLKLTQGETIRRLYEQRHVVQDMLVPMKHLQAAITRFHQDIKVYPLWLCPFLLLPGRGMVHPKGDQEE-----------------LYVDIGAYGEPKVKHFEAKASTRQLEKFVRDCHGFQMLYADVYMDREEFWEMFDGQLYHRLREELGCKDAFPEVYSKICKSARH 516
[Close]
BLAST of delta(24)-sterol reductase vs. Ensembl Medaka
Match: dhcr24 (24-dehydrocholesterol reductase [Source:NCBI gene;Acc:101172722])

HSP 1 Score: 556.214 bits (1432), Expect = 0.000e+0
Identity = 272/530 (51.32%), Postives = 364/530 (68.68%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEK----------------KFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            L + +V+ RWIFV  FLLPLSV++++   +R  IIF + SAPK H+ RV+++Q+Q+R W   G+K+ +CT RPGW T+S RVGKYK     I IN++D+L V+ ++                K V+VEPL  M Q++A L  +GWT+PV+PELDDLTVGGL+MGTGIE+SSH +GLFQHIC+  +LVL DG L+ CS  EN DLF+A  WS GT+GFLV+A+IKI+ AK ++K+   P   ++++  +F +E      N FVE L +S DS VVMTG M+   +  K IN IG  +KPWFFKHVE  +K E     E+IP+R YYHRH+RSIFWE+QDIIPFGNN +FR LFGW VPPKISLLKLTQGE I+++YE  HV+QDMLVP++++Q ++  F++++ ++PLWLCPF L    G+V P  D+ E                 +YVDIG YG PKV  ++A  +TR LE FVR   GFQMLYAD YM R+EF +MF+  LY ++RE+   + AFPE+Y KI K AR+
Sbjct:   23 LEHVLVHQRWIFVCAFLLPLSVIFDVYYYVRAWIIFKMCSAPKLHDQRVRDVQRQVREWRKDGAKSHMCTGRPGWLTVSLRVGKYKKTHKNILINMMDILEVDTKRQHTVNKRGRLTNKFNTKVVKVEPLANMGQVTALLNGMGWTLPVLPELDDLTVGGLVMGTGIESSSHIYGLFQHICVAYELVLADGSLVRCSEEENVDLFHAVPWSCGTLGFLVAAEIKIVPAKPWVKLRLEPVRGLENICRRF-AEASSNKQNTFVEGLQYSLDSAVVMTGTMTDHAEPDK-INRIGLHFKPWFFKHVEGYLK-EGRTGVEYIPLRQYYHRHTRSIFWELQDIIPFGNNPVFRWLFGWMVPPKISLLKLTQGETIRRLYEQRHVVQDMLVPMKHLQAAITRFHQDIKVYPLWLCPFLLLPGRGMVHPKGDQEE-----------------LYVDIGAYGEPKVKHFEAKASTRQLEKFVRDCHGFQMLYADVYMDREEFWEMFDGQLYHRLREELGCKDAFPEVYSKICKSARH 532
[Close]
BLAST of delta(24)-sterol reductase vs. Planmine SMEST
Match: SMESG000076611.1 (SMESG000076611.1)

HSP 1 Score: 1100.12 bits (2844), Expect = 0.000e+0
Identity = 530/530 (100.00%), Postives = 530/530 (100.00%), Query Frame = 3 
Query:   84 MEPLKYFKNNSWHQRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 1673
            MEPLKYFKNNSWHQRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN
Sbjct:    1 MEPLKYFKNNSWHQRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQSETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWFFKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKISKDARN 530
[Close]
BLAST of delta(24)-sterol reductase vs. Planmine SMEST
Match: SMESG000022021.1 (SMESG000022021.1)

HSP 1 Score: 342.043 bits (876), Expect = 6.701e-110
Identity = 200/526 (38.02%), Postives = 295/526 (56.08%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTK--LCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSP-TENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEK---FQSETMKPFDN--EFVEALVFSPDSGVVMTGN-MSCKPKNKKQ-INSIGSFYKPWFFKHVEFIMKQEISV----FTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRHLFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNKEVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVDIGVYGVPKV----STYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFNHSLYDKVREKYHSEAAFPEIYDKI 1655
            L  F+  +R + V++F LP S ++ +L N R  ++   +     H  RV+ IQKQ+R W     + +  LC +RP W ++S    K K    KI I L  +L  NE K+ V VEP VT+ Q++  LL   + +    E+ D T GGL MG G+ T SHK GLFQ   +   LVL DG  I      E+ +L++   WSHG++GFLVS ++KII A  YIK+ Y P   M++   +   F        DN  +F+EA VFS D  V++ G+ +  K   K   IN I  +YKPWF+KHVE  +K+ I+       E IPI+DY  RH+RSIFW ++ IIPF NN +FR  FGW  PPK + LK T    I+    V  V QD+++P+  +++S+    K  +I+P+ + P +LF       P+     ++      +  V+  Y M+ D+GVYGVP+       YD     R++E F+R  GG+  LYAD +M ++EF +MF+ S Y+K+ +KYH++ AFP +YDK+
Sbjct:    7 LVEFLEEHRGLVVVMFCLPASFVFGLLINFRTYLVQLFSRFSGSHLDRVRKIQKQVRKWNEIPKENRKLLCNSRPNWLSLSTTFFK-KEECQKIEIPLFQILEFNEMKRTVTVEPYVTVGQITDYLLKRKFVLACTLEISDATCGGLAMGVGMTTHSHKVGLFQESVVSYGLVLSDGSFIHVEKDNEHSNLYHCLPWSHGSLGFLVSLELKIISATDYIKLRYRPVVGMENYCNQMRIFSGAESSYNDNIPDFLEATVFSHDESVIIFGDFIEIKTHTKNYYINDISKWYKPWFYKHVESFLKKPINADGFSGEEIIPIKDYLFRHNRSIFWVLEAIIPFCNNPLFRLFFGWMCPPKPAFLKFTTTPGIRAFTFVKQVFQDIVLPMTALEESIELSEKLFNIYPILIYPCKLF----FQNPS---RGLLRNPKTIQMTVDSDYGMFYDLGVYGVPRAIKLKQKYDPSKAMRSMEKFIRDQGGYSFLYADIFMNKEEFCEMFDLSNYEKICQKYHADNAFPHLYDKV 524
[Close]
BLAST of delta(24)-sterol reductase vs. Planmine SMEST
Match: SMESG000022021.1 (SMESG000022021.1)

HSP 1 Score: 165.236 bits (417), Expect = 3.956e-46
Identity = 101/270 (37.41%), Postives = 146/270 (54.07%), Query Frame = 3 
Query:  132 LAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRIIFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTK--LCTARPGWKTMSFRVGKYKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVMPELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSP-TENEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEK---FQSETMKPFDN--EFVEALVFSPDSGVVMTGN 917
            L  F+  +R + V++F LP S ++ +L N R  ++   +     H  RV+ IQKQ+R W     + +  LC +RP W ++S    K K    KI I L  +L  NE K+ V VEP VT+ Q++  LL   + +    E+ D T GGL MG G+ T SHK GLFQ   +   LVL DG  I      E+ +L++   WSHG++GFLVS ++KII A  YIK+ Y P   M++   +   F        DN  +F+EA VFS D  V++ G+
Sbjct:    7 LVEFLEEHRGLVVVMFCLPASFVFGLLINFRTYLVQLFSRFSGSHLDRVRKIQKQVRKWNEIPKENRKLLCNSRPNWLSLSTTFFK-KEECQKIEIPLFQILEFNEMKRTVTVEPYVTVGQITDYLLKRKFVLACTLEISDATCGGLAMGVGMTTHSHKVGLFQESVVSYGLVLSDGSFIHVEKDNEHSNLYHCLPWSHGSLGFLVSLELKIISATDYIKLRYRPVVGMENYCNQMRIFSGAESSYNDNIPDFLEATVFSHDESVIIFGD 275
The following BLAST results are available for this feature:
BLAST of delta(24)-sterol reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
DHCR240.000e+055.0624-dehydrocholesterol reductase [Source:HGNC Symbo... [more]
DHCR240.000e+055.0624-dehydrocholesterol reductase [Source:HGNC Symbo... [more]
DHCR240.000e+053.8024-dehydrocholesterol reductase [Source:HGNC Symbo... [more]
DHCR248.845e-5564.1224-dehydrocholesterol reductase [Source:HGNC Symbo... [more]
DHCR247.079e-5365.5724-dehydrocholesterol reductase [Source:HGNC Symbo... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
F52H2.61.789e-16646.69Diminuto-like protein [Source:UniProtKB/Swiss-Pro... [more]
Y7A5A.12.985e-11135.71pep chromosome:WBcel235:X:15767437:15771509:-1 gen... [more]
Y7A5A.12.985e-11135.71pep chromosome:WBcel235:X:15767437:15771493:-1 gen... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of delta(24)-sterol reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dhcr240.000e+054.2824-dehydrocholesterol reductase [Source:ZFIN;Acc:Z... [more]
dhcr244.629e-12354.2124-dehydrocholesterol reductase [Source:ZFIN;Acc:Z... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
dhcr240.000e+054.0924-dehydrocholesterol reductase [Source:NCBI gene;... [more]
txlnb3.768e-828.95taxilin beta [Source:Xenbase;Acc:XB-GENE-876994][more]
txlnb4.525e-828.95taxilin beta [Source:Xenbase;Acc:XB-GENE-876994][more]
txlnb4.614e-828.95taxilin beta [Source:Xenbase;Acc:XB-GENE-876994][more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Dhcr240.000e+054.8624-dehydrocholesterol reductase [Source:MGI Symbol... [more]
Gulo1.631e-1032.14gulonolactone (L-) oxidase [Source:MGI Symbol;Acc:... [more]
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BLAST of delta(24)-sterol reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q15392|DHC24_HUMAN0.000e+055.06Delta(24)-sterol reductase OS=Homo sapiens OX=9606... [more]
sp|Q60HC5|DHC24_MACFA0.000e+055.06Delta(24)-sterol reductase OS=Macaca fascicularis ... [more]
sp|Q5BQE6|DHC24_RAT0.000e+054.86Delta(24)-sterol reductase OS=Rattus norvegicus OX... [more]
sp|Q8VCH6|DHC24_MOUSE0.000e+054.86Delta(24)-sterol reductase OS=Mus musculus OX=1009... [more]
sp|O17397|DIML_CAEEL2.276e-16546.69Diminuto-like protein OS=Caenorhabditis elegans OX... [more]
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BLAST of delta(24)-sterol reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3JWJ90.000e+057.47delta(24)-sterol reductase OS=Lingula unguis OX=75... [more]
A0A210QJU80.000e+056.84Delta(24)-sterol reductase OS=Mizuhopecten yessoen... [more]
A0A267ECF40.000e+056.31FAD-binding PCMH-type domain-containing protein OS... [more]
A0A267GHJ00.000e+056.31FAD-binding PCMH-type domain-containing protein OS... [more]
V4BLP60.000e+056.05FAD-binding PCMH-type domain-containing protein OS... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
dhcr240.000e+052.1424-dehydrocholesterol reductase [Source:ZFIN;Acc:Z... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
dhcr240.000e+054.4624-dehydrocholesterol reductase [Source:ZFIN;Acc:Z... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ALO15.073e-732.35D-Arabinono-1,4-lactone oxidase; catalyzes the fin... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO362410.000e+054.72Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO449351.898e-727.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of delta(24)-sterol reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dhcr240.000e+052.7224-dehydrocholesterol reductase [Source:NCBI gene;... [more]
dhcr240.000e+051.3224-dehydrocholesterol reductase [Source:NCBI gene;... [more]
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BLAST of delta(24)-sterol reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000076611.10.000e+0100.00SMESG000076611.1[more]
SMESG000022021.16.701e-11038.02SMESG000022021.1[more]
SMESG000022021.13.956e-4637.41SMESG000022021.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30026195 ID=SMED30026195|Name=delta(24)-sterol reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=1796bp
TTGAAGTTCGCATGTTACATTTCAAAGTCCACAGTTGAAAAGTTATGTAT
AAGTTATTTGCACAATGATTTTTATAACGAAAAATGGAACCATTAAAATA
TTTCAAAAATAATTCATGGCACCAAAGACTTCTAGCATATTTTATAGTTA
ATTATCGGTGGATTTTTGTTTTAATTTTCTTGTTACCACTGTCAGTTTTA
TATAACATCCTTTCAAATATTAGAGATAGGATCATTTTTTATTTAAATAG
TGCTCCTAAATTCCATGAGACTCGAGTTAAAAATATACAAAAACAAATCA
GAACTTGGTGGATGAGCGGGTCGAAAACAAAATTATGTACTGCTAGACCA
GGATGGAAAACTATGTCGTTTAGAGTGGGGAAATATAAATCTAATAGTCA
CAAAATTTATATAAATTTAATTGATGTTCTTTTTGTTAATGAAGAAAAGA
AATTTGTTCGAGTTGAACCGTTAGTTACAATGAAACAGCTATCTGCAACC
TTATTACCTCTTGGTTGGACAATTCCTGTAATGCCAGAATTAGACGATCT
AACAGTTGGTGGTCTTATAATGGGCACTGGGATAGAGACATCTTCACATA
AACACGGATTGTTTCAGCACATTTGTATTGAACTGAAATTGGTTCTTCAC
GATGGCGAACTAATTACTTGTTCTCCTACAGAAAATGAAGACCTATTTTA
TGCTGCATTCTGGTCACATGGAACTATAGGTTTTCTTGTATCTGCTGATA
TAAAAATAATACGAGCTAAATCATATATAAAGGTAGATTATTATCCATGT
CATTCAATGGATGATTTGGTGGAGAAATTTCAATCAGAAACTATGAAACC
TTTCGACAATGAATTCGTAGAGGCTCTTGTGTTTTCCCCTGATTCCGGGG
TAGTGATGACAGGCAACATGAGCTGCAAACCAAAAAATAAAAAGCAGATA
AATTCTATAGGAAGCTTCTATAAACCTTGGTTTTTCAAACACGTTGAATT
CATTATGAAGCAAGAAATAAGTGTATTTACAGAATTTATTCCAATTCGGG
ATTATTATCACCGTCACTCTCGCAGCATATTCTGGGAGATACAGGATATT
ATTCCATTTGGTAACAATTCGATCTTTCGACATCTTTTCGGTTGGGCAGT
TCCTCCAAAGATATCTTTACTTAAATTAACTCAGGGCGAAGTAATTAAAA
AGATGTATGAGGTCAGTCATGTGTTACAAGATATGCTTGTTCCTATAAGA
TATATTCAAGATTCTTTATTATTTTTCAACAAGGAGGTTTCTATTTTCCC
GCTTTGGCTCTGTCCTTTTCGATTATTCAAACTCCCAGGATTAGTGCAAC
CAAATTTTGACAAATCGGAGATAATTCATCAAATAAGTTTTCAGAAAAAT
GATGTCAACGAAAAATATGTAATGTATGTTGATATTGGAGTTTATGGTGT
CCCGAAAGTTTCAACGTATGACGCTTTCAATACTACGCGTAATTTAGAAG
CGTTTGTAAGAAGGGTTGGGGGTTTCCAAATGTTATATGCAGATACATAT
ATGACAAGGAAAGAGTTCCGAGATATGTTTAATCACTCTTTGTATGACAA
AGTCAGGGAAAAATATCACAGTGAGGCTGCATTTCCAGAGATCTATGACA
AGATCTCCAAAGATGCCAGAAATTGATTATTCTTCGTGACATTGATGACT
TGATAATATAATGGTTGTGAAAGGTTTTATTTATTTAAAATTATTAAACT
TATAATTTTATTTTTACTTTCCTAAATAAATCTTATTACACGATTG
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protein sequence of SMED30026195-orf-1

>SMED30026195-orf-1 ID=SMED30026195-orf-1|Name=SMED30026195-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=531bp
MEPLKYFKNNSWHQRLLAYFIVNYRWIFVLIFLLPLSVLYNILSNIRDRI
IFYLNSAPKFHETRVKNIQKQIRTWWMSGSKTKLCTARPGWKTMSFRVGK
YKSNSHKIYINLIDVLFVNEEKKFVRVEPLVTMKQLSATLLPLGWTIPVM
PELDDLTVGGLIMGTGIETSSHKHGLFQHICIELKLVLHDGELITCSPTE
NEDLFYAAFWSHGTIGFLVSADIKIIRAKSYIKVDYYPCHSMDDLVEKFQ
SETMKPFDNEFVEALVFSPDSGVVMTGNMSCKPKNKKQINSIGSFYKPWF
FKHVEFIMKQEISVFTEFIPIRDYYHRHSRSIFWEIQDIIPFGNNSIFRH
LFGWAVPPKISLLKLTQGEVIKKMYEVSHVLQDMLVPIRYIQDSLLFFNK
EVSIFPLWLCPFRLFKLPGLVQPNFDKSEIIHQISFQKNDVNEKYVMYVD
IGVYGVPKVSTYDAFNTTRNLEAFVRRVGGFQMLYADTYMTRKEFRDMFN
HSLYDKVREKYHSEAAFPEIYDKISKDARN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0071949FAD binding
GO:0016491oxidoreductase activity
GO:0003824catalytic activity
GO:0016614oxidoreductase activity, acting on CH-OH group of donors
GO:0050660flavin adenine dinucleotide binding
GO:0000246delta24(24-1) sterol reductase activity
GO:0016628oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899enzyme binding
GO:0042605peptide antigen binding
GO:0050614delta24-sterol reductase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR040165Diminuto-like
IPR036318FAD-bd_PCMH-like_sf
IPR006094Oxid_FAD_bind_N
IPR016169FAD-bd_PCMH_sub2
IPR016166FAD-bd_PCMH
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
GO:0006629lipid metabolic process
GO:0006694steroid biosynthetic process
GO:0006695cholesterol biosynthetic process
GO:0006915apoptotic process
GO:0006979response to oxidative stress
GO:0007050cell cycle arrest
GO:0007265Ras protein signal transduction
GO:0008104protein localization
GO:0008202steroid metabolic process
GO:0008203cholesterol metabolic process
GO:0008285negative regulation of cell proliferation
GO:0009725response to hormone
GO:0009888tissue development
GO:0016125sterol metabolic process
GO:0016126sterol biosynthetic process
GO:0030539male genitalia development
GO:0031639plasminogen activation
GO:0033489cholesterol biosynthetic process via desmosterol
GO:0033490cholesterol biosynthetic process via lathosterol
GO:0042987amyloid precursor protein catabolic process
GO:0043066negative regulation of apoptotic process
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588skin development
GO:0061024membrane organization
GO:1901214regulation of neuron death
Vocabulary: cellular component
TermDefinition
GO:0000139Golgi membrane
GO:0005634nucleus
GO:0005737cytoplasm
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0005794Golgi apparatus
GO:0005829cytosol
GO:0005856cytoskeleton
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR016169FAD-binding, type PCMH, subdomain 2GENE3DG3DSA:3.30.465.10coord: 111..229
e-value: 6.9E-27
score: 95.6
IPR006094FAD linked oxidase, N-terminalPFAMPF01565FAD_binding_4coord: 114..197
e-value: 7.5E-12
score: 45.2
IPR040165Delta(24)-sterol reductasePANTHERPTHR1080124-DEHYDROCHOLESTEROL REDUCTASEcoord: 13..529
NoneNo IPR availablePANTHERPTHR10801:SF0DELTA(24)-STEROL REDUCTASEcoord: 13..529
NoneNo IPR availableTMHMMTMhelixcoord: 21..43
IPR016166FAD-binding domain, PCMH-typePROSITEPS51387FAD_PCMHcoord: 53..228
score: 10.725
IPR036318FAD-binding, type PCMH-like superfamilySUPERFAMILYSSF56176FAD-binding/transporter-associated domain-likecoord: 112..226