Amiloride-sensitive sodium channel subunit gamma

Overview
NameAmiloride-sensitive sodium channel subunit gamma
Smed IDSMED30026192
Length (bp)585
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Amiloride-sensitive sodium channel subunit gamma (SMED30026192) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Amiloride-sensitive sodium channel subunit gamma (SMED30026192) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30026192

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30026192SMESG000053477.1 dd_Smed_v4_26469_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30026192SMESG000053477.1 dd_Smed_v4_26469_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30026192SMESG000053477.1 dd_Smed_v4_26469_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 87.0409 bits (214), Expect = 1.621e-19
Identity = 44/158 (27.85%), Postives = 79/158 (50.00%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            ++  C+    ++   C   +++   +    C T C   C  TSY ++  Y  WPS  + E +   L   +++      N        V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ EL++D  +I+  M+++RF+ +
Sbjct:  500 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN-------GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR 650
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 87.0409 bits (214), Expect = 1.782e-19
Identity = 44/158 (27.85%), Postives = 79/158 (50.00%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            ++  C+    ++   C   +++   +    C T C   C  TSY ++  Y  WPS  + E +   L   +++      N        V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ EL++D  +I+  M+++RF+ +
Sbjct:  464 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN-------GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR 614
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 86.6557 bits (213), Expect = 2.268e-19
Identity = 44/158 (27.85%), Postives = 79/158 (50.00%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            ++  C+    ++   C   +++   +    C T C   C  TSY ++  Y  WPS  + E +   L   +++      N        V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ EL++D  +I+  M+++RF+ +
Sbjct:  441 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN-------GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR 591
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 82.8037 bits (203), Expect = 2.648e-18
Identity = 44/158 (27.85%), Postives = 79/158 (50.00%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            ++  C+    ++   C   +++   +    C T C   C  TSY ++  Y  WPS  + E +   L   +++      N        V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ EL++D  +I+  M+++RF+ +
Sbjct:  141 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN-------GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR 291
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Human
Match: ASIC3 (acid sensing ion channel subunit 3 [Source:HGNC Symbol;Acc:HGNC:101])

HSP 1 Score: 60.4622 bits (145), Expect = 2.633e-11
Identity = 34/107 (31.78%), Postives = 55/107 (51.40%), Query Frame = 2 
Query:  137 CKKTSYSMTVSYCNWPSKIALETILNKL-RSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C  T Y+  +S    PS+ A   +  KL RS            E ++ E VL ++I+F++L Y  + +   Y    L+ D+GGQMGL++G S+   LEI + + + F
Sbjct:    1 CASTRYAKELSMVRIPSRAAARFLARKLNRS------------EAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVF 95
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Celegans
Match: del-4 (DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P91835])

HSP 1 Score: 68.9366 bits (167), Expect = 8.679e-14
Identity = 41/126 (32.54%), Postives = 67/126 (53.17%), Query Frame = 2 
Query:  113 DCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQ 490
            DC +C   C+  SY +TVS   WPS   + T  N       + +     L+ +    +L IEIY++ + +  ++ESP YT  + ISD+GGQ+GL+LG+S+ + +E   LI+  F        +R +
Sbjct:  354 DC-DCPQPCEIDSYGVTVSTAQWPSDSYVPTECNPGGPSGPWDASGESCLDWYKANTIL-IEIYYERMNFQVLTESPAYTFVNFISDVGGQVGLFLGMSIISAIEYLVLIFLVFFYCCTHKSRRAE 477
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 66.2402 bits (160), Expect = 1.025e-12
Identity = 39/112 (34.82%), Postives = 58/112 (51.79%), Query Frame = 2 
Query:  113 DCTNCTLVCKKTSYSMTVSYCNWPSKIA--LETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            DC  C   C++T+Y +T S   WPS  A  +E +         +   KN  +          ++I+++ L Y  + ESP YT  S+++DLGG  GLW+G SV + LEI  LI
Sbjct:  666 DCY-CHQPCQETNYEVTYSSARWPSGSAKVMECLPGDFLCLEKYR--KNAAM----------VQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 764
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 66.2402 bits (160), Expect = 1.025e-12
Identity = 39/112 (34.82%), Postives = 58/112 (51.79%), Query Frame = 2 
Query:  113 DCTNCTLVCKKTSYSMTVSYCNWPSKIA--LETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            DC  C   C++T+Y +T S   WPS  A  +E +         +   KN  +          ++I+++ L Y  + ESP YT  S+++DLGG  GLW+G SV + LEI  LI
Sbjct:  666 DCY-CHQPCQETNYEVTYSSARWPSGSAKVMECLPGDFLCLEKYR--KNAAM----------VQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 764
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 66.2402 bits (160), Expect = 1.058e-12
Identity = 39/112 (34.82%), Postives = 58/112 (51.79%), Query Frame = 2 
Query:  113 DCTNCTLVCKKTSYSMTVSYCNWPSKIA--LETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            DC  C   C++T+Y +T S   WPS  A  +E +         +   KN  +          ++I+++ L Y  + ESP YT  S+++DLGG  GLW+G SV + LEI  LI
Sbjct:  666 DCY-CHQPCQETNYEVTYSSARWPSGSAKVMECLPGDFLCLEKYR--KNAAM----------VQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 764
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 65.855 bits (159), Expect = 1.268e-12
Identity = 39/112 (34.82%), Postives = 58/112 (51.79%), Query Frame = 2 
Query:  113 DCTNCTLVCKKTSYSMTVSYCNWPSKIA--LETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            DC  C   C++T+Y +T S   WPS  A  +E +         +   KN  +          ++I+++ L Y  + ESP YT  S+++DLGG  GLW+G SV + LEI  LI
Sbjct:  693 DCY-CHQPCQETNYEVTYSSARWPSGSAKVMECLPGDFLCLEKYR--KNAAM----------VQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLI 791
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Zebrafish
Match: asic4b (acid-sensing (proton-gated) ion channel family member 4b [Source:NCBI gene;Acc:407667])

HSP 1 Score: 68.9366 bits (167), Expect = 1.925e-13
Identity = 43/153 (28.10%), Postives = 73/153 (47.71%), Query Frame = 2 
Query:   71 CITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMII--KRFQKKTG*RKLIYQ 523
            C+      ++  T D   C   C  T Y   +S    PS           R  + + S K +  E ++ +  L ++I+F++L Y  I +   Y    L+ D+GGQMGL++G S+   LEI + IY+     ++ ++  K+ QK+T  R LI +
Sbjct:  351 CVDKALASLQKSTGDSCPCETPCNLTRYGKELSMVKIPS-----------RGSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKPKKSQKQTNQRNLIQE 492
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Zebrafish
Match: asic1c (acid-sensing (proton-gated) ion channel 1c [Source:NCBI gene;Acc:407670])

HSP 1 Score: 64.3142 bits (155), Expect = 2.579e-12
Identity = 38/133 (28.57%), Postives = 65/133 (48.87%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF--LILLQMIIKRFQKKTG*RKLI 517
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+     IL  ++ KR   ++    L+
Sbjct:   83 CDTPCNMTRYGKELSMVKIPSKASAKYLAKKF-----------NKTEQYITDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVLKDKILGSVLRKRRPHRSASDNLV 204
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Zebrafish
Match: asic1c (acid-sensing (proton-gated) ion channel 1c [Source:NCBI gene;Acc:407670])

HSP 1 Score: 64.6994 bits (156), Expect = 5.514e-12
Identity = 38/133 (28.57%), Postives = 65/133 (48.87%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF--LILLQMIIKRFQKKTG*RKLI 517
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+     IL  ++ KR   ++    L+
Sbjct:  363 CDTPCNMTRYGKELSMVKIPSKASAKYLAKKFNK-----------TEQYITDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVLKDKILGSVLRKRRPHRSASDNLV 484
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Zebrafish
Match: asic1a (acid-sensing (proton-gated) ion channel 1a [Source:NCBI gene;Acc:791696])

HSP 1 Score: 64.3142 bits (155), Expect = 6.746e-12
Identity = 33/112 (29.46%), Postives = 60/112 (53.57%), Query Frame = 2 
Query:  113 DCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYD 448
            D  +C   C  T YS  +S+   PSK +++           + + K    E ++ E V+ ++++F++L Y  I +   Y    L+ D+GGQMGL++G S+   LE+F+ +Y+
Sbjct:  361 DYCSCETPCNITRYSKELSFVKIPSKASVK-----------YLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLYE 461
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Zebrafish
Match: asic4a (acid-sensing (proton-gated) ion channel family member 4a [Source:NCBI gene;Acc:407668])

HSP 1 Score: 63.5438 bits (153), Expect = 1.027e-11
Identity = 40/148 (27.03%), Postives = 70/148 (47.30%), Query Frame = 2 
Query:   41 NINYQTTDDI-CITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIK 481
            + N  T  DI C+      ++  + D   C   C  T Y   +S    PSK +           + + S K +  E ++ +  L ++I+F++L Y  I +   Y    L+ D+GGQMGL++G SV   LEI + +Y+     L+ +++
Sbjct:  144 DANICTPSDIKCVDKALALLQKSSGDTCFCETPCNLTRYGKELSMVKIPSKGS-----------ARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVYEVIKHRLERLLR 280
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Xenopus
Match: copg2 (coatomer protein complex subunit gamma 2 [Source:Xenbase;Acc:XB-GENE-941264])

HSP 1 Score: 67.781 bits (164), Expect = 7.130e-13
Identity = 41/161 (25.47%), Postives = 78/161 (48.45%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKKTG*R 508
            +  CN N       C   +   + + T  C T C   CK+T Y ++     WPS ++    L  L+   +  S +++         + +I +Y++ L+Y  + E+P+ +   L+S +GG    W G SV +  EI EL+ DT  +++ ++I +++K+   R
Sbjct:  401 MEYCNYNKHPDWGYCFYQLYEKMLDHTLICFTQCPKQCKQTEYHLSAGTAKWPSPVSKAKKLLSLQERYNSTSKRSD---------ISKINVYYEELSYRSVEETPSVSVTMLLSSMGGLWSWWFGSSVLSVAEIAELVLDTVAMVI-IVIYQWKKQRAKR 551
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Xenopus
Match: cspg4 (chondroitin sulfate proteoglycan 4 [Source:Xenbase;Acc:XB-GENE-5893460])

HSP 1 Score: 65.855 bits (159), Expect = 3.036e-12
Identity = 37/122 (30.33%), Postives = 64/122 (52.46%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYD--TFLILLQMIIKR 484
            CT+ C  T Y+  +S    PSK + + +  K               E ++L+ +L ++++F++L Y  I +   Y    L+ D+GGQMGL++G S+   LE+F+ IY+  TFL   +   +R
Sbjct:  389 CTIPCNVTRYNKELSMVKIPSKTSAKYLEKKF-----------NKSEKYILDNILVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYIYEVITFLKSCEHACRR 499
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Xenopus
Match: foxe3 (forkhead box E3 [Source:Xenbase;Acc:XB-GENE-480592])

HSP 1 Score: 65.855 bits (159), Expect = 3.188e-12
Identity = 41/156 (26.28%), Postives = 75/156 (48.08%), Query Frame = 2 
Query:   38 CNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIA--LETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            CN N       C   +   + +    C T C + C KT Y ++     WPS  +     +L +L    +  + +++         +L+I +Y++ L+Y  + E+P      L+S++GGQ   W G SV + +EI EL++DT  + + M   R++K+
Sbjct:  404 CNYNKHPGWGHCFYQLYEKMLDHRHHCFTQCPMQCTKTRYQLSAGTAQWPSPTSKVCAFLLLELECKVTLFNFRSD---------ILKINVYYEELSYQSVEETPAMPVTLLLSNMGGQWSWWFGSSVLSVVEIAELVFDTVAMAILMTY-RWKKQ 549
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Xenopus
Match: copg2 (coatomer protein complex subunit gamma 2 [Source:Xenbase;Acc:XB-GENE-941264])

HSP 1 Score: 65.4698 bits (158), Expect = 3.922e-12
Identity = 42/164 (25.61%), Postives = 78/164 (47.56%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPS---KIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKKTG*R 508
            +  CN N       C   +   + + T  C T C   CK+T Y ++     WPS   K++ + I  K + +             + L  + +I +Y++ L+Y  + E+P+ +   L+S +GG    W G SV +  EI EL+ DT  +++ ++I +++K+   R
Sbjct:  401 MEYCNYNKHPDWGYCFYQLYEKMLDHTLICFTQCPKQCKQTEYHLSAGTAKWPSPVSKVSNDYITIKAKVYWGV----------WELSDISKINVYYEELSYRSVEETPSVSVTMLLSSMGGLWSWWFGSSVLSVAEIAELVLDTVAMVI-IVIYQWKKQRAKR 553
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Xenopus
Match: cspg4 (chondroitin sulfate proteoglycan 4 [Source:Xenbase;Acc:XB-GENE-5893460])

HSP 1 Score: 64.6994 bits (156), Expect = 7.933e-12
Identity = 33/109 (30.28%), Postives = 59/109 (54.13%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDT 451
            CT+ C  T Y+  +S    PSK + + +  K               E ++L+ +L ++++F++L Y  I +   Y    L+ D+GGQMGL++G S+   LE+F+ IY++
Sbjct:  389 CTIPCNVTRYNKELSMVKIPSKTSAKYLEKKF-----------NKSEKYILDNILVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYIYES 486
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 80.1073 bits (196), Expect = 2.711e-17
Identity = 47/157 (29.94%), Postives = 79/157 (50.32%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+   Q++   C   ++      +  C + C   C  T+Y ++  Y  WPS  + + I   L S  +  ++ N+         V ++ I+F  L Y   SESP+ T  SL+S+LG Q  LW G SV + +E+ ELI+D  +I L M++ RF+ +
Sbjct:  444 VEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEML-SLQNNYTINNKR------NGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSR 593
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 80.1073 bits (196), Expect = 2.711e-17
Identity = 47/157 (29.94%), Postives = 79/157 (50.32%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+   Q++   C   ++      +  C + C   C  T+Y ++  Y  WPS  + + I   L S  +  ++ N+         V ++ I+F  L Y   SESP+ T  SL+S+LG Q  LW G SV + +E+ ELI+D  +I L M++ RF+ +
Sbjct:  444 VEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEML-SLQNNYTINNKR------NGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSR 593
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 80.1073 bits (196), Expect = 2.896e-17
Identity = 47/157 (29.94%), Postives = 79/157 (50.32%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+   Q++   C   ++      +  C + C   C  T+Y ++  Y  WPS  + + I   L S  +  ++ N+         V ++ I+F  L Y   SESP+ T  SL+S+LG Q  LW G SV + +E+ ELI+D  +I L M++ RF+ +
Sbjct:  470 VEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEML-SLQNNYTINNKR------NGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSR 619
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 76.2554 bits (186), Expect = 5.200e-16
Identity = 48/157 (30.57%), Postives = 77/157 (49.04%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+   Q++   C   ++      +  C + C   C  T+Y ++  Y  WPS  + + I   L       SL+N          V ++ I+F  L Y   SESP+ T  SL+S+LG Q  LW G SV + +E+ ELI+D  +I L M++ RF+ +
Sbjct:  363 VEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEML-------SLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSR 512
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Mouse
Match: Scnn1a (sodium channel, nonvoltage-gated 1 alpha [Source:MGI Symbol;Acc:MGI:101782])

HSP 1 Score: 76.2554 bits (186), Expect = 5.398e-16
Identity = 48/157 (30.57%), Postives = 77/157 (49.04%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+   Q++   C   ++      +  C + C   C  T+Y ++  Y  WPS  + + I   L       SL+N          V ++ I+F  L Y   SESP+ T  SL+S+LG Q  LW G SV + +E+ ELI+D  +I L M++ RF+ +
Sbjct:  363 VEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEML-------SLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSR 512
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. UniProt/SwissProt
Match: sp|P37088|SCNNA_HUMAN (Amiloride-sensitive sodium channel subunit alpha OS=Homo sapiens OX=9606 GN=SCNN1A PE=1 SV=1)

HSP 1 Score: 86.6557 bits (213), Expect = 1.089e-18
Identity = 44/158 (27.85%), Postives = 79/158 (50.00%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            ++  C+    ++   C   +++   +    C T C   C  TSY ++  Y  WPS  + E +   L   +++      N        V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ EL++D  +I+  M+++RF+ +
Sbjct:  441 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN-------GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR 591
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. UniProt/SwissProt
Match: sp|H2Q5A1|SCNNA_PANTR (Amiloride-sensitive sodium channel subunit alpha OS=Pan troglodytes OX=9598 GN=SCNN1A PE=3 SV=2)

HSP 1 Score: 86.2705 bits (212), Expect = 1.382e-18
Identity = 45/158 (28.48%), Postives = 78/158 (49.37%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            ++  C+    ++   C   +++   +    C T C   C  TSY ++  Y  WPS  + E +   L   +++      N        V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ ELI+D  +I   M+++RF+ +
Sbjct:  464 NVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRN-------GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITFLMLLRRFRSR 614
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. UniProt/SwissProt
Match: sp|P55270|SCNNA_BOVIN (Amiloride-sensitive sodium channel subunit alpha OS=Bos taurus OX=9913 GN=SCNN1A PE=1 SV=2)

HSP 1 Score: 81.6481 bits (200), Expect = 5.258e-17
Identity = 45/157 (28.66%), Postives = 79/157 (50.32%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+     +   C   ++    +    C T C   C  T Y ++ SY  WPS  + + +   L   +++ ++KN+       + V ++ I+F  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ ELI D  +I   M+++RF+ +
Sbjct:  423 VEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTIYKLSASYSQWPSATSQDWVFQMLSRQNNY-TIKNKR------DGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIIDLLVITFLMLLRRFRSR 572
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. UniProt/SwissProt
Match: sp|Q61180|SCNNA_MOUSE (Amiloride-sensitive sodium channel subunit alpha OS=Mus musculus OX=10090 GN=Scnn1a PE=1 SV=2)

HSP 1 Score: 80.1073 bits (196), Expect = 1.986e-16
Identity = 47/157 (29.94%), Postives = 79/157 (50.32%), Query Frame = 2 
Query:   29 LRMCNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            +  C+   Q++   C   ++      +  C + C   C  T+Y ++  Y  WPS  + + I   L S  +  ++ N+         V ++ I+F  L Y   SESP+ T  SL+S+LG Q  LW G SV + +E+ ELI+D  +I L M++ RF+ +
Sbjct:  469 VEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEML-SLQNNYTINNKR------NGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSR 618
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. UniProt/SwissProt
Match: sp|O97741|SCNNA_RABIT (Amiloride-sensitive sodium channel subunit alpha OS=Oryctolagus cuniculus OX=9986 GN=SCNN1A PE=2 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 3.141e-16
Identity = 45/154 (29.22%), Postives = 74/154 (48.05%), Query Frame = 2 
Query:   38 CNINYQTTDDICITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            C+     +   C   ++    +    C T C   C  T+Y ++  Y  WPS  + + +   L       SL+N          V ++ IYF  L Y   SESP+ T  +L+S+LG Q  LW G SV + +E+ EL++D  +I   M+++RF+ +
Sbjct:  422 CDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTNYELSAGYSRWPSVTSQDWVFQML-------SLQNNYTVSNKRNGVAKLNIYFKELNYKANSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELLFDLSVITFLMLLRRFRSR 568
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. TrEMBL
Match: R7TJB5 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_212550 PE=3 SV=1)

HSP 1 Score: 92.4337 bits (228), Expect = 2.094e-19
Identity = 48/150 (32.00%), Postives = 80/150 (53.33%), Query Frame = 2 
Query:   38 CNINYQTTDDICITNIKIGIKNGTFDCTN-CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRS-----FSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQ 469
            C +  +  +D C +N+      G  +C+  C   C+   Y + VS   WP  + L +++  L +     F +   +  E    F  E +L++E+Y+ +L Y +I  +P+Y    L+S+LGGQ GLWLG SV A  E+ ELI D F+++L+
Sbjct:   60 CLVTRKYENDACSSNVFDLFALGALNCSKECAPECEIYDYHLHVSXTKWPPNVGLPSMVKTLSNRDPTYFRNIPQMAEEEQLEFFDENMLKLEVYYQALGYQQIITAPSYGVLELLSELGGQTGLWLGASVVALFELAELIADMFVLMLK 209
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. TrEMBL
Match: A0A1S3H9A1 (amiloride-sensitive sodium channel subunit alpha-like isoform X2 OS=Lingula unguis OX=7574 GN=LOC106152772 PE=3 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 2.039e-18
Identity = 56/163 (34.36%), Postives = 85/163 (52.15%), Query Frame = 2 
Query:   62 DDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFAS--LKNEN---LEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILL----QMIIKRFQKKTG*RKLIYQ 523
            DD C+  IK    +    C +C L C    YS   S   WPSK  + T+   L S  +     +  +N    EP   + +L++E+YF  L + +ISE+  Y  F+L++D+GGQ+G W+GLS+ A  E+ ELI D F +LL        K+ QK+   R++  Q
Sbjct:  509 DDECVAGIKRRFADDDLSC-DCPLTCVDVEYSGVPSLAKWPSKQYMSTLHATLASAGAHLDNIINGKNGMAAEPG--DNLLKLEVYFQELNFQKISENVAYDVFALLADIGGQIGFWVGLSIMALFEVVELILDVFRLLLFRVGSFCFKKQQKRPPSRQVKVQ 668
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. TrEMBL
Match: A0A1S3H4D2 (amiloride-sensitive sodium channel subunit alpha isoform X1 OS=Lingula unguis OX=7574 GN=LOC106152063 PE=3 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 2.054e-18
Identity = 56/163 (34.36%), Postives = 85/163 (52.15%), Query Frame = 2 
Query:   62 DDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFAS--LKNEN---LEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILL----QMIIKRFQKKTG*RKLIYQ 523
            DD C+  IK    +    C +C L C    YS   S   WPSK  + T+   L S  +     +  +N    EP   + +L++E+YF  L + +ISE+  Y  F+L++D+GGQ+G W+GLS+ A  E+ ELI D F +LL        K+ QK+   R++  Q
Sbjct:  530 DDECVAGIKRRFADDDLSC-DCPLTCVDVEYSGVPSLAKWPSKQYMSTLHATLASAGAHLDNIINGKNGMAAEPG--DNLLKLEVYFQELNFQKISENVAYDVFALLADIGGQIGFWVGLSIMALFEVVELILDVFRLLLFRVGSFCFKKQQKRPPSRQVKVQ 689
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. TrEMBL
Match: A0A1S3H932 (amiloride-sensitive sodium channel subunit alpha-like isoform X1 OS=Lingula unguis OX=7574 GN=LOC106152772 PE=3 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 2.062e-18
Identity = 56/163 (34.36%), Postives = 85/163 (52.15%), Query Frame = 2 
Query:   62 DDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFAS--LKNEN---LEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILL----QMIIKRFQKKTG*RKLIYQ 523
            DD C+  IK    +    C +C L C    YS   S   WPSK  + T+   L S  +     +  +N    EP   + +L++E+YF  L + +ISE+  Y  F+L++D+GGQ+G W+GLS+ A  E+ ELI D F +LL        K+ QK+   R++  Q
Sbjct:  542 DDECVAGIKRRFADDDLSC-DCPLTCVDVEYSGVPSLAKWPSKQYMSTLHATLASAGAHLDNIINGKNGMAAEPG--DNLLKLEVYFQELNFQKISENVAYDVFALLADIGGQIGFWVGLSIMALFEVVELILDVFRLLLFRVGSFCFKKQQKRPPSRQVKVQ 701
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. TrEMBL
Match: A0A3M6TVG9 (Uncharacterized protein OS=Pocillopora damicornis OX=46731 GN=pdam_00000881 PE=3 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 2.234e-17
Identity = 50/169 (29.59%), Postives = 90/169 (53.25%), Query Frame = 2 
Query:    5 YRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCT-NCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKKTG*R 508
            Y+       R C  + +T D  C+  +K     G  +C+ +C   CK++++  T SY  WP+  + +    KL++ +     ++++L     + +L++ ++F+ L Y  ISE P Y   S +SDLGG +GLW+G+SV  F EI ELI    L++   + ++ + + G R
Sbjct:  356 YKYPRPKSTRFCETSNKT-DRACVRKVKDYFIKGVLNCSQSCPPPCKESTFKFTTSYSLWPTTSSEKLYRAKLKARNKEVDGESDDLR----KHILKVNVFFEELNYEVISEDPAYELPSFMSDLGGSLGLWIGMSVLTFAEILELI----LLICYTLARKLKNRVGAR 515
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Cavefish
Match: asic4a (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103040152])

HSP 1 Score: 68.1662 bits (165), Expect = 2.418e-13
Identity = 45/154 (29.22%), Postives = 71/154 (46.10%), Query Frame = 2 
Query:   44 INYQTTDDICITNIKIG--------IKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIK 481
            ++   TDDIC  N KI         ++  + D   C   C  T Y   +S    PSK +           + + S K    E ++ +  L ++I+F++L Y  I +   Y    L+ D+GGQMGL++G S+   LEI + IY+     LQ  +K
Sbjct:  334 VHMPGTDDICPPN-KIKCVDRALALLQKSSGDSCPCETPCNLTRYGKELSMVKIPSKGS-----------ARYLSRKYHKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYIYEVVKRRLQRALK 475
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544])

HSP 1 Score: 65.855 bits (159), Expect = 1.780e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  363 CQTPCNMTRYGKELSMVKIPSKASAKYLAKKFNK-----------TEQYIGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 461
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Cavefish
Match: asic4b (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103044180])

HSP 1 Score: 65.855 bits (159), Expect = 1.824e-12
Identity = 45/161 (27.95%), Postives = 74/161 (45.96%), Query Frame = 2 
Query:   32 RMCN---INYQTTDDICITNIKIG--------IKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIK 481
            R CN   I+   + DIC T  K+         ++  T D   C   C  T Y   +S    PSK +           + + S K    E ++ +  L ++IYF++L Y  I +   Y    L+ D+GGQMGL++G S+   LEI + IY+     ++ +++
Sbjct:  331 RECNCRMIHMPGSADIC-TPAKVKCVDRALGLLQKSTGDSCPCETPCNVTRYGKELSMVKIPSKGS-----------ARYLSRKYHTTEDYIRDNFLILDIYFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVIKHRIKRLLR 479
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544])

HSP 1 Score: 65.4698 bits (158), Expect = 2.000e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  363 CQTPCNMTRYGKELSMVKIPSKASAKYLAKKFNK-----------TEQYIGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 461
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544])

HSP 1 Score: 65.0846 bits (157), Expect = 2.685e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  350 CQTPCNMTRYGKELSMVKIPSKASAKYLAKKFN-----------KTEQYIGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 448
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Sea Lamprey
Match: asic1a (acid-sensing (proton-gated) ion channel 1a [Source:NCBI gene;Acc:791696])

HSP 1 Score: 60.8474 bits (146), Expect = 1.959e-11
Identity = 37/125 (29.60%), Postives = 60/125 (48.00%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDS-LTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            C   C  T Y   +S    PSK +           + + + K    E ++ E VL ++I+F++ L Y  I +   Y    L+ D+GGQMGL++G S+   LEIF+ +Y+     +    K+  KK
Sbjct:  377 CDTPCNTTRYGKELSMVKIPSKAS-----------AKYLAKKYNKTEDYIRENVLVLDIFFEAALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTILEIFDYLYEVLKDKVCKCRKKHNKK 490
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Sea Lamprey
Match: asic1b (acid-sensing (proton-gated) ion channel 1b [Source:NCBI gene;Acc:407672])

HSP 1 Score: 59.3066 bits (142), Expect = 5.182e-11
Identity = 39/127 (30.71%), Postives = 60/127 (47.24%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTY--TGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFL--ILLQMIIKRFQK 493
            C   C  T Y   +S    PSK +           + + + K    E ++ E VL ++I+F++L Y  I +   Y   G     D+GGQMGL++G S+   LEIF+ +Y+     IL     K+ QK
Sbjct:  367 CETPCNMTRYGKELSMVKIPSKAS-----------AKYLAKKYNKTEAYIAENVLVLDIFFEALNYETIEQKKAYEVAGLLETGDIGGQMGLFIGASILTILEIFDYVYELIRDKILFYFRAKKKQK 482
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Sea Lamprey
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 57.7658 bits (138), Expect = 2.032e-10
Identity = 32/101 (31.68%), Postives = 55/101 (54.46%), Query Frame = 2 
Query:  113 DC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSV 412
            DC T C   C ++ Y M++S  +WPS+ + + I + L         +  N +    + ++++ ++F     + ISESP  T  +L+S+LGGQ G W+G SV
Sbjct:  442 DCYTICKQPCIESEYKMSISMSDWPSQSSEDWIFHILSKERKHNVSRIFNRK----QDIIKLNLFFQEFNSMTISESPAQTIVTLLSNLGGQFGFWMGGSV 538
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Sea Lamprey
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 57.3806 bits (137), Expect = 2.422e-10
Identity = 38/141 (26.95%), Postives = 66/141 (46.81%), Query Frame = 2 
Query:   26 DLRMCNI--NYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            D++ C++  +Y    D  +  +  G+  G    + C + C   ++  +VSY  +PS   L+      RS +       ENL        L I++ +  L Y  I +  T     L+SD+GGQ+GL++G SV   +E+ E +
Sbjct:  311 DIKECSLYQHYHCARDALVHILAQGMCTGGSHLSQCPVPCLHKNFPSSVSYATFPS---LQAAQRYERSLNYSLVYMRENL--------LSIDVAYTDLNYALIQQQKTLPESVLLSDIGGQLGLFVGASVITIIEVLEFV 440
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Sea Lamprey
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 57.3806 bits (137), Expect = 2.509e-10
Identity = 37/141 (26.24%), Postives = 68/141 (48.23%), Query Frame = 2 
Query:   26 DLRMCNI--NYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            D++ C++  +Y    D  +  +  G+  G    + C + C   ++  +VSY  +PS  A +     L          N +L  ++ E +L I++ +  L Y  I +  T     L+SD+GGQ+GL++G SV   +E+ E +
Sbjct:  321 DIKECSLYQHYHCARDALVIFLAQGMCTGGSHLSQCPVPCLHKNFPSSVSYATFPSLQAAQRYERSL----------NYSLV-YMRENLLSIDVAYTDLNYALIQQQKTLPESVLLSDIGGQLGLFVGASVITIIEVLEFV 450
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2])

HSP 1 Score: 72.7886 bits (177), Expect = 2.360e-15
Identity = 47/148 (31.76%), Postives = 76/148 (51.35%), Query Frame = 2 
Query:   26 DLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALET---------ILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            ++ +CN    T  D C+       ++G+ D   C   C + S+ +TVS   WP++    T         +LNK+ S SS   + +EN        + Q+ +Y+  L YL + E+  YT  SL+SD+GGQMG+W+G+S     E+ EL+
Sbjct:  348 NIPLCNRLNSTIID-CLNKAYDTFEDGSCD-RECPPSCSEVSFDLTVSSARWPARSFEVTKYAYFLRVRVLNKIASSSSKYFVNSEN--------IAQVHVYYGELDYLLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELV 485
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Nematostella
Match: EDO31696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX71])

HSP 1 Score: 71.2478 bits (173), Expect = 8.656e-15
Identity = 44/144 (30.56%), Postives = 74/144 (51.39%), Query Frame = 2 
Query:   71 CITNIKIGIKNGTFDC-TNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKKT 499
            C+  +K  +      C T C   C++ +Y +T S+  WPS+    +I++ L     F  + N +   F  +  L++ I+F  L Y  I ES  Y   + +SD+GGQ+GLW+G+SV    E+ EL     LI  ++  ++ +K T
Sbjct:  273 CLAKVKFKLSRNELGCSTACGPACREEAYRLTSSFAVWPSQRYQNSIIDNL-----FDGIFNYSRSWF-RDNYLEVNIFFKELNYF-IEESVAYELVNFLSDIGGQLGLWVGVSVMTGAEVVEL---ALLIFFKVFCRKPRKVT 406
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Nematostella
Match: EDO48656 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI82])

HSP 1 Score: 65.4698 bits (158), Expect = 8.931e-13
Identity = 32/108 (29.63%), Postives = 61/108 (56.48%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLE--PFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            C + C    YS  +SY  +P+        N  +  +    LK  + E   ++ + +++I+IY++ LTY ++ + P+Y  +SL+ D+GGQ+GL+LG S+   +E  +L+
Sbjct:  472 CPVACNSVEYSAQLSYARFPAN-------NYAKMLAKEYGLKGSDEENRQYLRDNLIEIKIYYEDLTYFDVQQVPSYDLYSLLGDVGGQIGLFLGASLLTVVEYLDLL 572
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Nematostella
Match: EDO37452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFR0])

HSP 1 Score: 65.0846 bits (157), Expect = 1.130e-12
Identity = 38/161 (23.60%), Postives = 79/161 (49.07%), Query Frame = 2 
Query:   23 VDLRMCNINYQTTDDI-------CITNIKIGIKNGTFDCT-NCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIK 481
            ++ R  NI+ +T  DI       C+  ++   ++    C+  C   C +  + +++S   WP+       L++L+    F    N +   + +    +++I+++ L +  I E  +Y   + +SD+GGQ+GLW+G+S     E+ EL+    L LL+ + +
Sbjct:  971 LEYRFPNIDNRTVCDILDIDVIRCLNKVQSLYQDNKLGCSEKCRPPCNEEVFKLSISSARWPTDDYEAHFLDELKEDKGFVLPANADARAYFV----KLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALHLLRKVTR 1127
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Nematostella
Match: EDO37667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF92])

HSP 1 Score: 64.6994 bits (156), Expect = 1.704e-12
Identity = 38/161 (23.60%), Postives = 79/161 (49.07%), Query Frame = 2 
Query:   23 VDLRMCNINYQTTDDI-------CITNIKIGIKNGTFDCT-NCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIK 481
            ++ R  NI+ +T  DI       C+  ++   ++    C+  C   C +  + +++S   WP+       L++L+    F    N +   + +    +++I+++ L +  I E  +Y   + +SD+GGQ+GLW+G+S     E+ EL+    L LL+ + +
Sbjct:   78 LEYRFPNIDNRTVCDILDIDVIRCLNKVQSLYQDNKLGCSEKCRPPCNEEVFKLSISSARWPTDDYEAHFLDELKEDKGFVLPANADARAYFV----KLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALHLLRKVTR 234
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Medaka
Match: ENSORLT00000021925.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 64.6994 bits (156), Expect = 3.552e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  360 CETPCNMTRYGKELSMVKIPSKASAKYLAKKFNK-----------TEQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 458
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Medaka
Match: asic4a (acid sensing ion channel subunit family member 4 [Source:NCBI gene;Acc:101159336])

HSP 1 Score: 64.6994 bits (156), Expect = 3.578e-12
Identity = 44/166 (26.51%), Postives = 77/166 (46.39%), Query Frame = 2 
Query:   29 LRMCN---INYQTTDDIC-------ITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            LR+C    ++   T DIC       +      ++  + D   C   C  T Y   +S    PSK +           + + S K +  E ++ +  L ++I+F++L Y  I +   Y    L+ D+GGQMGL++G S+   LEI + +++     LQ ++ R QK+
Sbjct:  323 LRVCKCRMVHMPGTADICPPSKISCVDKALAQLQKNSGDTCPCETPCNLTRYGKELSMVKIPSKGS-----------ARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYVFEVIRHRLQRLL-RPQKE 476
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Medaka
Match: ENSORLT00000015581.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 64.6994 bits (156), Expect = 4.143e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  350 CETPCNMTRYGKELSMVKIPSKASAKYLAKKFN-----------KTEQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 448
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Medaka
Match: ENSORLT00000035361.1 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 64.3142 bits (155), Expect = 5.566e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  384 CETPCNMTRYGKELSMVKIPSKASAKYLAKKF-----------NKTEQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 482
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Medaka
Match: ENSORLT00000021936.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 63.929 bits (154), Expect = 6.511e-12
Identity = 34/110 (30.91%), Postives = 56/110 (50.91%), Query Frame = 2 
Query:  125 CTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTF 454
            C   C  T Y   +S    PSK + + +  K               E ++ + +L ++I+F++L Y +I +   Y    L+ D+GGQMGL++G SV   LEIF+ +Y+ F
Sbjct:  384 CETPCNMTRYGKELSMVKIPSKASAKYLAKKF-----------NKTEQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 482
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Planmine SMEST
Match: SMESG000053477.1 (SMESG000053477.1)

HSP 1 Score: 321.242 bits (822), Expect = 1.237e-111
Identity = 157/165 (95.15%), Postives = 161/165 (97.58%), Query Frame = 2 
Query:    2 AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKK 496
            AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETI+NKLRSFSSFASL+NE LEP VL+QVLQIEIYFDSLTYLEISESPTYT  SLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQK+
Sbjct:  139 AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETIMNKLRSFSSFASLENEILEPLVLDQVLQIEIYFDSLTYLEISESPTYTVLSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKR 303
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Planmine SMEST
Match: SMESG000053446.1 (SMESG000053446.1)

HSP 1 Score: 184.882 bits (468), Expect = 1.381e-55
Identity = 102/179 (56.98%), Postives = 130/179 (72.63%), Query Frame = 2 
Query:    2 AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNE-NLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRFQKKTG*RKLIYQLDLH 535
            AYRNISSVDLRMC+INYQTTD IC  N KI I NGTFDC NC+L CKK SYS+TVS CNWPS IA ++I+N+L    + A L+   N +  +  Q++Q+EIYF+S+TYL+I+E P Y   SLISD GG MGLWLGLSVAA  EIFEL++DT + L++M++ R++      K  Y  + H
Sbjct:  380 AYRNISSVDLRMCDINYQTTDAICCANTKIAIMNGTFDCKNCSLACKKNSYSITVSNCNWPSTIAQQSIINQLSGLPAMAYLQQSVNSDNIISTQMMQLEIYFESMTYLDITEQPAYEFVSLISDFGGLMGLWLGLSVAACFEIFELLFDTIVTLVKMMVIRYRDSKRKIKQFYLQNWH 558
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Planmine SMEST
Match: SMESG000053446.1 (SMESG000053446.1)

HSP 1 Score: 182.956 bits (463), Expect = 3.545e-54
Identity = 99/163 (60.74%), Postives = 125/163 (76.69%), Query Frame = 2 
Query:    2 AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRSFSSFASLKNE-NLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDTFLILLQMIIKRF 487
            AYRNISSVDLRMC+INYQTTD IC  N KI I NGTFDC NC+L CKK SYS+TVS CNWPS IA ++I+N+L    + A L+   N +  +  Q++Q+EIYF+S+TYL+I+E P Y   SLISD GG MGLWLGLSVAA  EIFEL++DT + L++M++ R+
Sbjct:  380 AYRNISSVDLRMCDINYQTTDAICCANTKIAIMNGTFDCKNCSLACKKNSYSITVSNCNWPSTIAQQSIINQLSGLPAMAYLQQSVNSDNIISTQMMQLEIYFESMTYLDITEQPAYEFVSLISDFGGLMGLWLGLSVAACFEIFELLFDTIVTLVKMMVIRY 542
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Planmine SMEST
Match: SMESG000053477.1 (SMESG000053477.1)

HSP 1 Score: 142.51 bits (358), Expect = 1.009e-42
Identity = 66/67 (98.51%), Postives = 67/67 (100.00%), Query Frame = 2 
Query:    2 AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALE 202
            AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIAL+
Sbjct:  139 AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALD 205
[Close]
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Planmine SMEST
Match: SMESG000006412.1 (SMESG000006412.1)

HSP 1 Score: 56.9954 bits (136), Expect = 1.179e-9
Identity = 32/115 (27.83%), Postives = 54/115 (46.96%), Query Frame = 2 
Query:  101 NGTFDCTNCTLVCKKTSYSMTVSYCNWPSKIALETILNKLRS-FSSFASLKNENLEPFVLEQVLQIEIYFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELI 442
            N   +  NC   C  T+Y++  S+  WP+    +   N ++  + +F    NEN      + +  + IY +  +Y EI +   Y   + +SD+GG + L+LG SV    E  E I
Sbjct:  345 NDYLNVCNCNFACNTTTYTIKQSFAEWPASSYEKRFFNDIKDIYPNFNITSNENSH--ARQNLSNVFIYVEDRSYQEIYQIRAYKWDNFLSDIGGTLSLYLGFSVLTGFEFLEAI 457
The following BLAST results are available for this feature:
BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SCNN1A1.621e-1927.85sodium channel epithelial 1 alpha subunit [Source:... [more]
SCNN1A1.782e-1927.85sodium channel epithelial 1 alpha subunit [Source:... [more]
SCNN1A2.268e-1927.85sodium channel epithelial 1 alpha subunit [Source:... [more]
SCNN1A2.648e-1827.85sodium channel epithelial 1 alpha subunit [Source:... [more]
ASIC32.633e-1131.78acid sensing ion channel subunit 3 [Source:HGNC Sy... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
del-48.679e-1432.54DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P9183... [more]
unc-1051.025e-1234.82Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
unc-1051.025e-1234.82Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
unc-1051.058e-1234.82Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
unc-1051.268e-1234.82Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic4b1.925e-1328.10acid-sensing (proton-gated) ion channel family mem... [more]
asic1c2.579e-1228.57acid-sensing (proton-gated) ion channel 1c [Source... [more]
asic1c5.514e-1228.57acid-sensing (proton-gated) ion channel 1c [Source... [more]
asic1a6.746e-1229.46acid-sensing (proton-gated) ion channel 1a [Source... [more]
asic4a1.027e-1127.03acid-sensing (proton-gated) ion channel family mem... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
copg27.130e-1325.47coatomer protein complex subunit gamma 2 [Source:X... [more]
cspg43.036e-1230.33chondroitin sulfate proteoglycan 4 [Source:Xenbase... [more]
foxe33.188e-1226.28forkhead box E3 [Source:Xenbase;Acc:XB-GENE-480592... [more]
copg23.922e-1225.61coatomer protein complex subunit gamma 2 [Source:X... [more]
cspg47.933e-1230.28chondroitin sulfate proteoglycan 4 [Source:Xenbase... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Scnn1a2.711e-1729.94sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a2.711e-1729.94sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a2.896e-1729.94sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a5.200e-1630.57sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
Scnn1a5.398e-1630.57sodium channel, nonvoltage-gated 1 alpha [Source:M... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P37088|SCNNA_HUMAN1.089e-1827.85Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|H2Q5A1|SCNNA_PANTR1.382e-1828.48Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|P55270|SCNNA_BOVIN5.258e-1728.66Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|Q61180|SCNNA_MOUSE1.986e-1629.94Amiloride-sensitive sodium channel subunit alpha O... [more]
sp|O97741|SCNNA_RABIT3.141e-1629.22Amiloride-sensitive sodium channel subunit alpha O... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R7TJB52.094e-1932.00Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A1S3H9A12.039e-1834.36amiloride-sensitive sodium channel subunit alpha-l... [more]
A0A1S3H4D22.054e-1834.36amiloride-sensitive sodium channel subunit alpha i... [more]
A0A1S3H9322.062e-1834.36amiloride-sensitive sodium channel subunit alpha-l... [more]
A0A3M6TVG92.234e-1729.59Uncharacterized protein OS=Pocillopora damicornis ... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic4a2.418e-1329.22acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
asic1c1.780e-1230.91acid-sensing ion channel 1C-like [Source:NCBI gene... [more]
asic4b1.824e-1227.95acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
asic1c2.000e-1230.91acid-sensing ion channel 1C-like [Source:NCBI gene... [more]
asic1c2.685e-1230.91acid-sensing ion channel 1C-like [Source:NCBI gene... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic1a1.959e-1129.60acid-sensing (proton-gated) ion channel 1a [Source... [more]
asic1b5.182e-1130.71acid-sensing (proton-gated) ion channel 1b [Source... [more]
SCNN1B2.032e-1031.68sodium channel epithelial 1 beta subunit [Source:H... [more]
ASIC52.422e-1026.95acid sensing ion channel subunit family member 5 [... [more]
ASIC52.509e-1026.24acid sensing ion channel subunit family member 5 [... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO421372.360e-1531.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316968.656e-1530.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO486568.931e-1329.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374521.130e-1223.60Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO376671.704e-1223.60Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000021925.23.552e-1230.91acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
asic4a3.578e-1226.51acid sensing ion channel subunit family member 4 [... [more]
ENSORLT00000015581.24.143e-1230.91acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
ENSORLT00000035361.15.566e-1230.91acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
ENSORLT00000021936.26.511e-1230.91acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
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BLAST of Amiloride-sensitive sodium channel subunit gamma vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000053477.11.237e-11195.15SMESG000053477.1[more]
SMESG000053446.11.381e-5556.98SMESG000053446.1[more]
SMESG000053446.13.545e-5460.74SMESG000053446.1[more]
SMESG000053477.11.009e-4298.51SMESG000053477.1[more]
SMESG000006412.11.179e-927.83SMESG000006412.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30026192 ID=SMED30026192|Name=Amiloride-sensitive sodium channel subunit gamma|organism=Schmidtea mediterranea sexual|type=transcript|length=585bp
TGCGTATCGCAACATATCTTCCGTTGACCTGCGAATGTGTAACATTAACT
ATCAAACCACTGACGACATATGTATCACCAACATCAAGATCGGAATCAAG
AATGGTACTTTTGACTGTACAAATTGTACACTGGTCTGCAAAAAAACATC
TTATTCAATGACAGTCAGTTACTGCAATTGGCCTTCTAAAATAGCGCTGG
AAACTATCTTGAATAAATTGCGATCATTTTCAAGTTTTGCCTCATTAAAA
AATGAAAACCTGGAACCATTTGTTTTAGAGCAAGTTTTGCAAATTGAGAT
CTATTTTGATTCTCTTACATATTTAGAGATTTCTGAATCTCCGACTTATA
CGGGTTTCAGTTTGATTTCTGATCTTGGAGGTCAAATGGGTCTATGGTTA
GGACTATCCGTTGCTGCATTCTTGGAAATTTTTGAGTTGATCTACGACAC
GTTTCTGATTTTACTGCAGATGATAATTAAAAGATTCCAAAAAAAAACCG
GTTAAAGAAAATTGATTTATCAACTAGATTTGCACGTAAAAATATTTAAG
ATCATAAAAAATATTGGCAATATTTATTCTATTTG
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protein sequence of SMED30026192-orf-1

>SMED30026192-orf-1 ID=SMED30026192-orf-1|Name=SMED30026192-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=168bp
AYRNISSVDLRMCNINYQTTDDICITNIKIGIKNGTFDCTNCTLVCKKTS
YSMTVSYCNWPSKIALETILNKLRSFSSFASLKNENLEPFVLEQVLQIEI
YFDSLTYLEISESPTYTGFSLISDLGGQMGLWLGLSVAAFLEIFELIYDT
FLILLQMIIKRFQKKTG*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0005886plasma membrane
GO:0005887integral component of plasma membrane
GO:0005929cilium
GO:0016021integral component of membrane
GO:0016324apical plasma membrane
GO:0031514motile cilium
GO:0034706sodium channel complex
GO:0042995cell projection
GO:0060170ciliary membrane
GO:0070062extracellular exosome
Vocabulary: molecular function
TermDefinition
GO:0005272sodium channel activity
GO:0005515protein binding
GO:0015280ligand-gated sodium channel activity
GO:0050699WW domain binding
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0034220ion transmembrane transport
GO:0035725sodium ion transmembrane transport
GO:0050891multicellular organismal water homeostasis
GO:0050896response to stimulus
GO:0050909sensory perception of taste
GO:0055078sodium ion homeostasis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 126..142
score: 52.94
coord: 112..126
score: 48.27
coord: 42..62
score: 37.71
coord: 92..112
score: 25.9
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 20..146
e-value: 3.6E-26
score: 92.1
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 34..165
NoneNo IPR availableGENE3DG3DSA:2.60.470.10coord: 47..114
e-value: 2.4E-27
score: 97.8
NoneNo IPR availableGENE3DG3DSA:1.10.287.820coord: 10..46
e-value: 2.4E-27
score: 97.8
NoneNo IPR availableGENE3DG3DSA:1.10.287.770coord: 115..145
e-value: 2.4E-27
score: 97.8
NoneNo IPR availablePANTHERPTHR11690:SF124AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHAcoord: 34..165
NoneNo IPR availableTMHMMTMhelixcoord: 133..155