srebp protein

Overview


Name	srebp protein (AGZ94937.1)
Smed ID	SMED30026172
Length (bp)	3142

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of srebp protein (SMED30026172) t-SNE clustered cells

Violin plots show distribution of expression levels for srebp protein (SMED30026172) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of srebp protein (SMED30026172) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for srebp protein (SMED30026172) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30026172

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
Smed sexual biotype	SMED30026172	h1SMcG0006375	Contig30719	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30026172	h1SMcG0006375	Contig30719	newmark_ests	PMID:29674431 Fincher et al., 2018
nervous system	SMED30026172	h1SMcG0006375	dd_Smed_v4_3641_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30026172	h1SMcG0006375	dd_Smed_v4_3641_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30026172	h1SMcG0006375	dd_Smed_v4_3641_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
pharynx	SMED30026172	h1SMcG0006375	KF487122	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
central nervous system	SMED30026172	h1SMcG0006375	KF487122	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
progenitor cell	SMED30026172	h1SMcG0006375	KF487122	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
stem cell	SMED30026172	h1SMcG0006375	KF487122	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
parenchyma	SMED30026172	h1SMcG0006375	KF487122	smed_ncbi_20240424	PMID:24173799 Cowles et al., 2013
epidermis	SMED30026172	h1SMcG0006375	dd_Smed_v4_3641_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of srebp protein vs. Ensembl Human
Match: SREBF2 (sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290])

HSP 1 Score: 77.7962 bits (190), Expect = 6.409e-14
Identity = 55/152 (36.18%), Postives = 80/152 (52.63%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTL---AATLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL   + T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  247 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 397

[Close]

BLAST of srebp protein vs. Ensembl Human
Match: SREBF2 (sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290])

HSP 1 Score: 77.7962 bits (190), Expect = 7.173e-14
Identity = 55/152 (36.18%), Postives = 80/152 (52.63%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTL---AATLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL   + T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  217 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 367

[Close]

BLAST of srebp protein vs. Ensembl Human
Match: SREBF2 (sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290])

HSP 1 Score: 78.1814 bits (191), Expect = 7.879e-14
Identity = 55/152 (36.18%), Postives = 80/152 (52.63%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTL---AATLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL   + T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  247 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 397

[Close]

BLAST of srebp protein vs. Ensembl Human
Match: SREBF1 (sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11289])

HSP 1 Score: 77.0258 bits (188), Expect = 1.736e-13
Identity = 38/68 (55.88%), Postives = 51/68 (75.00%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +R +HNAIEKRYR SINDKI EL+  L +G ++K+NKS VL+KAI+ I+ L+  N  LK EN +LR +
Sbjct:  324 KRTAHNAIEKRYRSSINDKIIELKD-LVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTA 390

[Close]

BLAST of srebp protein vs. Ensembl Human
Match: SREBF1 (sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11289])

HSP 1 Score: 76.6406 bits (187), Expect = 2.080e-13
Identity = 38/68 (55.88%), Postives = 51/68 (75.00%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +R +HNAIEKRYR SINDKI EL+  L +G ++K+NKS VL+KAI+ I+ L+  N  LK EN +LR +
Sbjct:  324 KRTAHNAIEKRYRSSINDKIIELKD-LVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTA 390

[Close]

BLAST of srebp protein vs. Ensembl Celegans
Match: sbp-1 (Sterol regulatory element Binding Protein [Source:UniProtKB/TrEMBL;Acc:Q9XX00])

HSP 1 Score: 58.151 bits (139), Expect = 3.603e-8
Identity = 33/66 (50.00%), Postives = 48/66 (72.73%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLR 898
            RR +HN IEK+YR SIND+I +L+ +L  GD++K++KS  L++AIE I+ +E EN  LKH    +R
Sbjct:  356 RRTAHNLIEKKYRCSINDRIQQLK-VLLCGDEAKLSKSATLRRAIEHIEEVEHENQVLKHHVEQMR 420

[Close]

BLAST of srebp protein vs. Ensembl Fly
Match: SREBP (gene:FBgn0261283 transcript:FBtr0333877)

HSP 1 Score: 70.8626 bits (172), Expect = 5.291e-12
Identity = 34/62 (54.84%), Postives = 53/62 (85.48%), Query Frame = 2

Query:  698 VRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHE 883
            V+R++HNAIE+RYR SINDKI+EL++ L +G+ +K+NKS VL+K+I++I+ L+ +N+ LK E
Sbjct:  283 VKRSAHNAIERRYRTSINDKINELKN-LVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAE 343

[Close]

BLAST of srebp protein vs. Ensembl Fly
Match: SREBP (gene:FBgn0261283 transcript:FBtr0074873)

HSP 1 Score: 70.8626 bits (172), Expect = 5.291e-12
Identity = 34/62 (54.84%), Postives = 53/62 (85.48%), Query Frame = 2

Query:  698 VRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHE 883
            V+R++HNAIE+RYR SINDKI+EL++ L +G+ +K+NKS VL+K+I++I+ L+ +N+ LK E
Sbjct:  283 VKRSAHNAIERRYRTSINDKINELKN-LVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAE 343

[Close]

BLAST of srebp protein vs. Ensembl Fly
Match: SREBP (gene:FBgn0261283 transcript:FBtr0074874)

HSP 1 Score: 70.8626 bits (172), Expect = 5.291e-12
Identity = 34/62 (54.84%), Postives = 53/62 (85.48%), Query Frame = 2

Query:  698 VRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHE 883
            V+R++HNAIE+RYR SINDKI+EL++ L +G+ +K+NKS VL+K+I++I+ L+ +N+ LK E
Sbjct:  283 VKRSAHNAIERRYRTSINDKINELKN-LVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAE 343

[Close]

BLAST of srebp protein vs. Ensembl Fly
Match: SREBP (gene:FBgn0261283 transcript:FBtr0074875)

HSP 1 Score: 70.8626 bits (172), Expect = 5.291e-12
Identity = 34/62 (54.84%), Postives = 53/62 (85.48%), Query Frame = 2

Query:  698 VRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHE 883
            V+R++HNAIE+RYR SINDKI+EL++ L +G+ +K+NKS VL+K+I++I+ L+ +N+ LK E
Sbjct:  283 VKRSAHNAIERRYRTSINDKINELKN-LVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAE 343

[Close]

BLAST of srebp protein vs. Ensembl Zebrafish
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100037309])

HSP 1 Score: 79.337 bits (194), Expect = 2.088e-14
Identity = 40/68 (58.82%), Postives = 52/68 (76.47%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI ELR  L LG+D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  317 RRTTHNIIEKRYRSSINDKILELRD-LVLGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLTLKMA 383

[Close]

BLAST of srebp protein vs. Ensembl Zebrafish
Match: srebf1 (sterol regulatory element binding transcription factor 1 [Source:ZFIN;Acc:ZDB-GENE-090812-3])

HSP 1 Score: 77.411 bits (189), Expect = 7.689e-14
Identity = 39/67 (58.21%), Postives = 49/67 (73.13%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRI 901
            +R +HNAIEKRYR SINDKI EL+  L  G ++K+NKS VLKKAIE I+ L+  N  LK EN  L++
Sbjct:  318 KRTAHNAIEKRYRSSINDKIIELKD-LVAGTEAKLNKSAVLKKAIEYIRYLQQSNQKLKQENMALKM 383

[Close]

BLAST of srebp protein vs. Ensembl Xenopus
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100144677])

HSP 1 Score: 77.411 bits (189), Expect = 9.533e-14
Identity = 39/68 (57.35%), Postives = 50/68 (73.53%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VLKKAI+ IK L+  N  L+ EN  L+++
Sbjct:  271 RRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLA 337

[Close]

BLAST of srebp protein vs. Ensembl Xenopus
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100144677])

HSP 1 Score: 77.411 bits (189), Expect = 9.984e-14
Identity = 39/68 (57.35%), Postives = 50/68 (73.53%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VLKKAI+ IK L+  N  L+ EN  L+++
Sbjct:  306 RRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLA 372

[Close]

BLAST of srebp protein vs. Ensembl Xenopus
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100144677])

HSP 1 Score: 77.411 bits (189), Expect = 1.102e-13
Identity = 39/68 (57.35%), Postives = 50/68 (73.53%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VLKKAI+ IK L+  N  L+ EN  L+++
Sbjct:  298 RRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLA 364

[Close]

BLAST of srebp protein vs. Ensembl Xenopus
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100144677])

HSP 1 Score: 76.6406 bits (187), Expect = 1.766e-13
Identity = 39/67 (58.21%), Postives = 49/67 (73.13%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRI 901
            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VLKKAI+ IK L+  N  L+ EN  L++
Sbjct:  227 RRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKL 292

[Close]

BLAST of srebp protein vs. Ensembl Xenopus
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100144677])

HSP 1 Score: 75.8702 bits (185), Expect = 2.325e-13
Identity = 39/68 (57.35%), Postives = 50/68 (73.53%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VLKKAI+ IK L+  N  L+ EN  L+++
Sbjct:   40 RRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLA 106

[Close]

BLAST of srebp protein vs. Ensembl Mouse
Match: Srebf2 (sterol regulatory element binding factor 2 [Source:MGI Symbol;Acc:MGI:107585])

HSP 1 Score: 77.411 bits (189), Expect = 8.240e-14
Identity = 55/152 (36.18%), Postives = 79/152 (51.97%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAA---TLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL     T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  236 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 386

[Close]

BLAST of srebp protein vs. Ensembl Mouse
Match: Srebf2 (sterol regulatory element binding factor 2 [Source:MGI Symbol;Acc:MGI:107585])

HSP 1 Score: 77.411 bits (189), Expect = 8.637e-14
Identity = 55/152 (36.18%), Postives = 79/152 (51.97%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAA---TLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL     T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  196 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 346

[Close]

BLAST of srebp protein vs. Ensembl Mouse
Match: Srebf1 (sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606])

HSP 1 Score: 76.2554 bits (186), Expect = 1.874e-13
Identity = 38/66 (57.58%), Postives = 49/66 (74.24%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLR 898
            +R +HNAIEKRYR SINDKI EL+  L +G ++K+NKS VL+KAI+ I+ L+  N  LK EN  LR
Sbjct:  260 KRTAHNAIEKRYRSSINDKIVELKD-LVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLR 324

[Close]

BLAST of srebp protein vs. Ensembl Mouse
Match: Srebf1 (sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606])

HSP 1 Score: 76.2554 bits (186), Expect = 1.880e-13
Identity = 38/66 (57.58%), Postives = 49/66 (74.24%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLR 898
            +R +HNAIEKRYR SINDKI EL+  L +G ++K+NKS VL+KAI+ I+ L+  N  LK EN  LR
Sbjct:  294 KRTAHNAIEKRYRSSINDKIVELKD-LVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLR 358

[Close]

BLAST of srebp protein vs. Ensembl Mouse
Match: Srebf1 (sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606])

HSP 1 Score: 75.8702 bits (185), Expect = 2.230e-13
Identity = 38/66 (57.58%), Postives = 49/66 (74.24%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLR 898
            +R +HNAIEKRYR SINDKI EL+  L +G ++K+NKS VL+KAI+ I+ L+  N  LK EN  LR
Sbjct:  318 KRTAHNAIEKRYRSSINDKIVELKD-LVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLR 382

[Close]

BLAST of srebp protein vs. UniProt/SwissProt
Match: sp|A3KNA7|SRBP2_DANRE (Sterol regulatory element-binding protein 2 OS=Danio rerio OX=7955 GN=srebf2 PE=2 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 1.704e-13
Identity = 40/68 (58.82%), Postives = 52/68 (76.47%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI ELR  L LG+D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  321 RRTTHNIIEKRYRSSINDKILELRD-LVLGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLTLKMA 387

[Close]

BLAST of srebp protein vs. UniProt/SwissProt
Match: sp|Q60429|SRBP2_CRIGR (Sterol regulatory element-binding protein 2 OS=Cricetulus griseus OX=10029 GN=SREBF2 PE=2 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 2.646e-13
Identity = 55/152 (36.18%), Postives = 79/152 (51.97%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAA---TLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL     T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  245 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPLQTGALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 395

[Close]

BLAST of srebp protein vs. UniProt/SwissProt
Match: sp|Q12772|SRBP2_HUMAN (Sterol regulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=SREBF2 PE=1 SV=2)

HSP 1 Score: 78.1814 bits (191), Expect = 3.784e-13
Identity = 55/152 (36.18%), Postives = 80/152 (52.63%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTL---AATLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL   + T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  247 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 397

[Close]

BLAST of srebp protein vs. UniProt/SwissProt
Match: sp|Q6GQ26|SRBP2_XENLA (Sterol regulatory element-binding protein 2 OS=Xenopus laevis OX=8355 GN=srebf2 PE=2 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 5.082e-13
Identity = 39/68 (57.35%), Postives = 50/68 (73.53%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VLKKAI+ IK L+  N  L+ EN  L+++
Sbjct:  291 RRTTHNIIEKRYRSSINDKIMELKD-LVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLA 357

[Close]

BLAST of srebp protein vs. UniProt/SwissProt
Match: sp|Q3U1N2|SRBP2_MOUSE (Sterol regulatory element-binding protein 2 OS=Mus musculus OX=10090 GN=Srebf2 PE=1 SV=2)

HSP 1 Score: 77.411 bits (189), Expect = 5.764e-13
Identity = 55/152 (36.18%), Postives = 79/152 (51.97%), Query Frame = 2

Query:  470 LINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAA---TLIGMQPSKMATNXXXXXXXXXXXXXXXXV----RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +I T+S     LKT+   V+ +     L A++    +  L+ PTL     T++   P  M           G            RR +HN IEKRYR SINDKI EL+  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++
Sbjct:  236 IIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPPKEGERRTTHNIIEKRYRSSINDKIIELKD-LVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLA 386

[Close]

BLAST of srebp protein vs. TrEMBL
Match: U5YQ85 (Srebp protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=srebp PE=2 SV=1)

HSP 1 Score: 321.242 bits (822), Expect = 9.739e-99
Identity = 230/231 (99.57%), Postives = 231/231 (100.00%), Query Frame = 2

Query:  482 NSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNXXXXXXXXXXXXXXXXVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGCLFINSVEKSEKNVSNSNRGTKRPLIYXXXXXXXXSTHIV 1174
            NSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNTTETHSGTGIGTGGRGVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESLNQTGSSPSSNNSDGGHSIENSPSSSSMHSSSVNSGCLFINSVEKSEKNVSNSNRGTKRPLIYNLNNNN+NSTHIV
Sbjct:    1 NSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNTTETHSGTGIGTGGRGVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESLNQTGSSPSSNNSDGGHSIENSPSSSSMHSSSVNSGCLFINSVEKSEKNVSNSNRGTKRPLIYNLNNNNNNSTHIV 231

[Close]

BLAST of srebp protein vs. TrEMBL
Match: T1FYU9 (BHLH domain-containing protein OS=Helobdella robusta OX=6412 GN=20213997 PE=4 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 1.573e-13
Identity = 41/69 (59.42%), Postives = 53/69 (76.81%), Query Frame = 2

Query:  704 RNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKN 910
            +++HNAIEKRYR+SIND+I ELR +L  G DSK++KS VL+KAIE I+ L   NN LK EN  LR++ N
Sbjct:   11 KSTHNAIEKRYRMSINDRIVELRELLA-GKDSKLSKSAVLRKAIEYIRYLVANNNKLKQENMALRLASN 78

[Close]

BLAST of srebp protein vs. TrEMBL
Match: A0A493TDG9 (BHLH domain-containing protein OS=Anas platyrhynchos platyrhynchos OX=8840 PE=4 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 1.798e-12
Identity = 38/68 (55.88%), Postives = 52/68 (76.47%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +R +HNAIEKRYR SINDKI EL+  L +G ++K+NKS +L+KAIE I+ L+  N  LK EN +LR++
Sbjct:   69 KRTAHNAIEKRYRSSINDKIVELKD-LVVGTEAKLNKSAILRKAIEYIRYLQQSNQKLKQENLSLRMA 135

[Close]

BLAST of srebp protein vs. TrEMBL
Match: A0A3P8VEY1 (Sterol regulatory element binding transcription factor 2 OS=Cynoglossus semilaevis OX=244447 GN=SREBF2 PE=4 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 1.898e-12
Identity = 55/136 (40.44%), Postives = 73/136 (53.68%), Query Frame = 2

Query:  503 LKTNNHRVITSKP--PQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNXXXXXXXXXXXXXXXXVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            LKT +  + T KP   Q+L  M +      L TP     L      K+     +       G    G RR +HN IEKRYR SINDKI ELR  L +G+D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L++ 
Sbjct:   14 LKTESLVLTTLKPDGTQVLSTMQSPTGITTLTTPIQNTALQVPVGDKLPIKQLQPGFMGPGGVVKEGERRTTHNVIEKRYRSSINDKIVELRD-LVMGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLALKMG 148

[Close]

BLAST of srebp protein vs. TrEMBL
Match: A0A1S3IQD3 (sterol regulatory element-binding protein 2 OS=Lingula unguis OX=7574 GN=LOC106166192 PE=4 SV=1)

HSP 1 Score: 82.4185 bits (202), Expect = 2.602e-12
Identity = 40/68 (58.82%), Postives = 53/68 (77.94%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +R +HNAIEKRYRLSINDKI EL+  L  G D+K+NKS VL+KAIE +K ++ +NN LK EN  L+++
Sbjct:  266 KRTAHNAIEKRYRLSINDKILELKD-LVSGTDAKLNKSAVLRKAIEYVKYMQQQNNRLKQENMALKMA 332

[Close]

BLAST of srebp protein vs. Ensembl Cavefish
Match: srebf2 (sterol regulatory element-binding protein 2 [Source:NCBI gene;Acc:103038606])

HSP 1 Score: 78.5666 bits (192), Expect = 3.076e-14
Identity = 39/70 (55.71%), Postives = 52/70 (74.29%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKN 910
            RR +HN IEKRYR SINDKI ELR  L +G+D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++  
Sbjct:  364 RRTTHNIIEKRYRSSINDKILELRD-LVMGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLALKMASQ 432

[Close]

BLAST of srebp protein vs. Ensembl Cavefish
Match: srebf2 (sterol regulatory element-binding protein 2 [Source:NCBI gene;Acc:103038606])

HSP 1 Score: 78.5666 bits (192), Expect = 3.159e-14
Identity = 39/70 (55.71%), Postives = 52/70 (74.29%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKN 910
            RR +HN IEKRYR SINDKI ELR  L +G+D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++  
Sbjct:  364 RRTTHNIIEKRYRSSINDKILELRD-LVMGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLALKMASQ 432

[Close]

BLAST of srebp protein vs. Ensembl Cavefish
Match: ENSAMXT00000040124.1 (sterol regulatory element binding transcription factor 1 [Source:NCBI gene;Acc:103027171])

HSP 1 Score: 74.7146 bits (182), Expect = 4.059e-13
Identity = 37/68 (54.41%), Postives = 50/68 (73.53%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            +R +HNAIEKRYR SINDKI EL+  L  G ++K+NKS VL+KAI+ I+ L+  N  LK EN  L+++
Sbjct:  360 KRTAHNAIEKRYRSSINDKIIELKD-LVAGTEAKLNKSAVLRKAIDYIRYLQQSNQKLKQENMALKMA 426

[Close]

BLAST of srebp protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010363.1 (pep scaffold:Pmarinus_7.0:GL479040:40436:43769:1 gene:ENSPMAG00000009384.1 transcript:ENSPMAT00000010363.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 76.2554 bits (186), Expect = 2.085e-16
Identity = 40/68 (58.82%), Postives = 51/68 (75.00%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS 904
            RR+SHNAIE+RYR SIND+I E+R ML +G  +K+NKS VL+KAI+ IK L+  N  LK EN  L+ S
Sbjct:   79 RRSSHNAIERRYRCSINDRIGEMRSML-VGPHNKLNKSAVLRKAIDYIKFLQQVNRRLKQENTALKRS 145

[Close]

BLAST of srebp protein vs. Ensembl Sea Lamprey
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:100037309])

HSP 1 Score: 77.0258 bits (188), Expect = 1.560e-14
Identity = 38/70 (54.29%), Postives = 51/70 (72.86%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKN 910
            +R +HNAIEKRYR SINDKI EL+ M+  G + K+NKS+VL+KAIE I+ L+  N  LK EN  L+++  
Sbjct:  255 KRTAHNAIEKRYRSSINDKIVELKDMIA-GSEGKLNKSSVLRKAIEYIRYLQQSNQKLKQENLVLKMAAQ 323

[Close]

BLAST of srebp protein vs. Ensembl Nematostella
Match: EDO44513 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVU6])

HSP 1 Score: 68.9366 bits (167), Expect = 8.536e-12
Identity = 34/69 (49.28%), Postives = 53/69 (76.81%), Query Frame = 2

Query:  704 RNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKN 910
            R++HN IEKRYR SIN++I+EL+  L  G ++KMNK+ +LKKA++ I+ L+ EN  LK EN  L+++++
Sbjct:   36 RSNHNEIEKRYRNSINNRINELKD-LVCGPETKMNKAGILKKALDYIRYLQRENGRLKEENTALKVAQH 103

[Close]

BLAST of srebp protein vs. Ensembl Medaka
Match: srebf2 (sterol regulatory element binding transcription factor 2 [Source:NCBI gene;Acc:101155853])

HSP 1 Score: 80.4925 bits (197), Expect = 6.942e-15
Identity = 42/75 (56.00%), Postives = 55/75 (73.33%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRIS--KNLPI 919
            RR +HN IEKRYR SINDKI ELR  L +G D+KM+KS VL+KAI+ IK L+  N+ L+ EN  L+++  KN P+
Sbjct:  388 RRTTHNIIEKRYRSSINDKIVELRD-LVMGSDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLALKVANQKNKPV 461

[Close]

BLAST of srebp protein vs. Ensembl Medaka
Match: srebf1 (sterol regulatory element binding transcription factor 1 [Source:NCBI gene;Acc:101163083])

HSP 1 Score: 75.485 bits (184), Expect = 2.322e-13
Identity = 38/70 (54.29%), Postives = 50/70 (71.43%), Query Frame = 2

Query:  701 RRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKN 910
            +R +HNAIEKRYR SINDKI EL+  L  G ++K+NKS VLKKAI+ I+ L+  N  LK EN  L+++  
Sbjct:  363 KRTAHNAIEKRYRSSINDKIVELKD-LVAGTEAKLNKSAVLKKAIDYIRYLQQANQKLKQENMALKMAAQ 431

[Close]

BLAST of srebp protein vs. Planmine SMEST
Match: SMESG000056019.1 (SMESG000056019.1)

HSP 1 Score: 1707.96 bits (4422), Expect = 0.000e+0
Identity = 977/978 (99.90%), Postives = 977/978 (99.90%), Query Frame = 2

Query:   50 MDDILNLTDDDISNFLDIPNDDEIFRELDSLEFTNEIENDLIYEYEIEKHLSNGDTYKQYTDPYSSHEXXXXXXXXXXXXXXXGNIKPNCINVSKNEVHDNAEQKLMIIRELLDSDIHDSTNGIISALQNNNHRSNTTKPLINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNXXXXXXXXXXXXXXXXVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGCLFINSVEKSEKNVSNSNRGTKRPLIYXXXXXXXXSTHIVKNEKLARLLLDHKDEYSNKSYEVQANRNSKKLHSSNVPGFLLCGIALFVVSFQPFDFLVRKYQSKHSTITGGRQLLFSNHGDFSGQGYLFALFLTLAHWSVAFILVYGSASNRFFXXXXXXXXXXXXXXXXWSVCLIKTANLTHNLVELKIDLKENYQNHNLFQSRIESLAEEYGCSCQVNPFMKVFQFTAYILNFFTNFLQIILNQKKCLSETRKINVYILTVIIDQATIGQLCYSKFEIFWYKILFFLSSWNLEINDEILFSKFTFALSISTGFIRRYFLKRIFETANRHQDLVSCRXXXXXXXXXXXEMLIKTSPQSLMNKFDLQNMDKRIDLDKQSLMNYYFMNYAQDTIESASQIILDGKPPHNDILNQLKDIINYSPAILNDTESTYFSXXXXXXXXXXKDQNSQHINKVVTKLISHYSSLTKMVVIKNSNDSIKSSFGIXXXXXXXXXXCGNEEDKLYHEINIKCMESITQSANMNVVFRMILRLSLTRIVQSLKMCNSNTFTNISNIVYYCNAYFKQLSKHYKHQSEIEVEMMSEFEALFHNLCQLNPMKCMALKLQEKDSTKSVSSSPLKKPNDNCFRITDFLSLERDSKLRSH 2983
            MDDILNLTDDDISNFLDIPNDDEIFRELDSLEFTNEIENDLIYEYEIEKHLSNGDTYKQYTDPYSSHENNVNYVNNNVYVNNYGNIKPNCINVSKNEVHDNAEQKLMIIRELLDSDIHDSTNGIIS LQNNNHRSNTTKPLINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNTTETHSGTGIGTGGRGVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESLNQTGSSPSSNNSDGGHSIENSPSSSSMHSSSVNSGCLFINSVEKSEKNVSNSNRGTKRPLIYNLNNNNDNSTHIVKNEKLARLLLDHKDEYSNKSYEVQANRNSKKLHSSNVPGFLLCGIALFVVSFQPFDFLVRKYQSKHSTITGGRQLLFSNHGDFSGQGYLFALFLTLAHWSVAFILVYGSASNRFFLKKMIALLLKKLQSSLWSVCLIKTANLTHNLVELKIDLKENYQNHNLFQSRIESLAEEYGCSCQVNPFMKVFQFTAYILNFFTNFLQIILNQKKCLSETRKINVYILTVIIDQATIGQLCYSKFEIFWYKILFFLSSWNLEINDEILFSKFTFALSISTGFIRRYFLKRIFETANRHQDLVSCRLQLFLLNNNLQEMLIKTSPQSLMNKFDLQNMDKRIDLDKQSLMNYYFMNYAQDTIESASQIILDGKPPHNDILNQLKDIINYSPAILNDTESTYFSLWCCLLLQLLKDQNSQHINKVVTKLISHYSSLTKMVVIKNSNDSIKSSFGILQLLLSTLQLCGNEEDKLYHEINIKCMESITQSANMNVVFRMILRLSLTRIVQSLKMCNSNTFTNISNIVYYCNAYFKQLSKHYKHQSEIEVEMMSEFEALFHNLCQLNPMKCMALKLQEKDSTKSVSSSPLKKPNDNCFRITDFLSLERDSKLRSH
Sbjct:    1 MDDILNLTDDDISNFLDIPNDDEIFRELDSLEFTNEIENDLIYEYEIEKHLSNGDTYKQYTDPYSSHENNVNYVNNNVYVNNYGNIKPNCINVSKNEVHDNAEQKLMIIRELLDSDIHDSTNGIISVLQNNNHRSNTTKPLINTNSPPNEHLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATNTTETHSGTGIGTGGRGVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDSKMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESLNQTGSSPSSNNSDGGHSIENSPSSSSMHSSSVNSGCLFINSVEKSEKNVSNSNRGTKRPLIYNLNNNNDNSTHIVKNEKLARLLLDHKDEYSNKSYEVQANRNSKKLHSSNVPGFLLCGIALFVVSFQPFDFLVRKYQSKHSTITGGRQLLFSNHGDFSGQGYLFALFLTLAHWSVAFILVYGSASNRFFLKKMIALLLKKLQSSLWSVCLIKTANLTHNLVELKIDLKENYQNHNLFQSRIESLAEEYGCSCQVNPFMKVFQFTAYILNFFTNFLQIILNQKKCLSETRKINVYILTVIIDQATIGQLCYSKFEIFWYKILFFLSSWNLEINDEILFSKFTFALSISTGFIRRYFLKRIFETANRHQDLVSCRLQLFLLNNNLQEMLIKTSPQSLMNKFDLQNMDKRIDLDKQSLMNYYFMNYAQDTIESASQIILDGKPPHNDILNQLKDIINYSPAILNDTESTYFSLWCCLLLQLLKDQNSQHINKVVTKLISHYSSLTKMVVIKNSNDSIKSSFGILQLLLSTLQLCGNEEDKLYHEINIKCMESITQSANMNVVFRMILRLSLTRIVQSLKMCNSNTFTNISNIVYYCNAYFKQLSKHYKHQSEIEVEMMSEFEALFHNLCQLNPMKCMALKLQEKDSTKSVSSSPLKKPNDNCFRITDFLSLERDSKLRSH 978

The following BLAST results are available for this feature:

BLAST of srebp protein vs. Ensembl Human
BLAST of srebp protein vs. Ensembl Celegans
BLAST of srebp protein vs. Ensembl Fly
BLAST of srebp protein vs. Ensembl Zebrafish
BLAST of srebp protein vs. Ensembl Xenopus
BLAST of srebp protein vs. Ensembl Mouse
BLAST of srebp protein vs. UniProt/SwissProt
BLAST of srebp protein vs. TrEMBL
BLAST of srebp protein vs. Ensembl Cavefish
BLAST of srebp protein vs. Ensembl Sea Lamprey
BLAST of srebp protein vs. Ensembl Yeast
BLAST of srebp protein vs. Ensembl Nematostella
BLAST of srebp protein vs. Ensembl Medaka
BLAST of srebp protein vs. Planmine SMEST

BLAST of srebp protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SREBF2	6.409e-14	36.18	sterol regulatory element binding transcription fa...	[more]
SREBF2	7.173e-14	36.18	sterol regulatory element binding transcription fa...	[more]
SREBF2	7.879e-14	36.18	sterol regulatory element binding transcription fa...	[more]
SREBF1	1.736e-13	55.88	sterol regulatory element binding transcription fa...	[more]
SREBF1	2.080e-13	55.88	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
sbp-1	3.603e-8	50.00	Sterol regulatory element Binding Protein [Source...	[more]

BLAST of srebp protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
SREBP	5.291e-12	54.84	gene:FBgn0261283 transcript:FBtr0333877	[more]
SREBP	5.291e-12	54.84	gene:FBgn0261283 transcript:FBtr0074873	[more]
SREBP	5.291e-12	54.84	gene:FBgn0261283 transcript:FBtr0074874	[more]
SREBP	5.291e-12	54.84	gene:FBgn0261283 transcript:FBtr0074875	[more]

BLAST of srebp protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
srebf2	2.088e-14	58.82	sterol regulatory element binding transcription fa...	[more]
srebf1	7.689e-14	58.21	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
srebf2	9.533e-14	57.35	sterol regulatory element binding transcription fa...	[more]
srebf2	9.984e-14	57.35	sterol regulatory element binding transcription fa...	[more]
srebf2	1.102e-13	57.35	sterol regulatory element binding transcription fa...	[more]
srebf2	1.766e-13	58.21	sterol regulatory element binding transcription fa...	[more]
srebf2	2.325e-13	57.35	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Srebf2	8.240e-14	36.18	sterol regulatory element binding factor 2 [Source...	[more]
Srebf2	8.637e-14	36.18	sterol regulatory element binding factor 2 [Source...	[more]
Srebf1	1.874e-13	57.58	sterol regulatory element binding transcription fa...	[more]
Srebf1	1.880e-13	57.58	sterol regulatory element binding transcription fa...	[more]
Srebf1	2.230e-13	57.58	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|A3KNA7\|SRBP2_DANRE	1.704e-13	58.82	Sterol regulatory element-binding protein 2 OS=Dan...	[more]
sp\|Q60429\|SRBP2_CRIGR	2.646e-13	36.18	Sterol regulatory element-binding protein 2 OS=Cri...	[more]
sp\|Q12772\|SRBP2_HUMAN	3.784e-13	36.18	Sterol regulatory element-binding protein 2 OS=Hom...	[more]
sp\|Q6GQ26\|SRBP2_XENLA	5.082e-13	57.35	Sterol regulatory element-binding protein 2 OS=Xen...	[more]
sp\|Q3U1N2\|SRBP2_MOUSE	5.764e-13	36.18	Sterol regulatory element-binding protein 2 OS=Mus...	[more]

BLAST of srebp protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
U5YQ85	9.739e-99	99.57	Srebp protein (Fragment) OS=Schmidtea mediterranea...	[more]
T1FYU9	1.573e-13	59.42	BHLH domain-containing protein OS=Helobdella robus...	[more]
A0A493TDG9	1.798e-12	55.88	BHLH domain-containing protein OS=Anas platyrhynch...	[more]
A0A3P8VEY1	1.898e-12	40.44	Sterol regulatory element binding transcription fa...	[more]
A0A1S3IQD3	2.602e-12	58.82	sterol regulatory element-binding protein 2 OS=Lin...	[more]

BLAST of srebp protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
srebf2	3.076e-14	55.71	sterol regulatory element-binding protein 2 [Sourc...	[more]
srebf2	3.159e-14	55.71	sterol regulatory element-binding protein 2 [Sourc...	[more]
ENSAMXT00000040124.1	4.059e-13	54.41	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000010363.1	2.085e-16	58.82	pep scaffold:Pmarinus_7.0:GL479040:40436:43769:1 g...	[more]
srebf2	1.560e-14	54.29	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of srebp protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO44513	8.536e-12	49.28	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of srebp protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
srebf2	6.942e-15	56.00	sterol regulatory element binding transcription fa...	[more]
srebf1	2.322e-13	54.29	sterol regulatory element binding transcription fa...	[more]

BLAST of srebp protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000056019.1	0.000e+0	99.90	SMESG000056019.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30026172
GenBank	AGZ94937.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30026172 ID=SMED30026172|Name=srebp protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3142bp
ACAAAATTGAAATAAATAATTTATGAAAATTAATATAAATTAATCGTTAA
TGGATGACATATTAAATCTCACAGATGATGATATATCTAATTTTTTGGAC
ATTCCTAACGATGACGAAATATTCAGGGAACTTGATTCACTAGAATTTAC
TAACGAAATAGAAAATGATTTGATATACGAATATGAAATAGAGAAACATT
TATCAAATGGAGATACTTATAAGCAGTATACTGATCCATATAGCAGCCAT
GAAAACAATGTTAATTATGTCAATAATAATGTATATGTAAATAATTATGG
AAATATAAAACCTAACTGTATAAATGTGTCCAAAAATGAAGTTCACGACA
ATGCCGAACAAAAGTTGATGATCATTCGGGAATTACTCGATTCCGATATT
CATGATTCTACTAATGGAATCATATCAGCATTACAGAATAATAACCACAG
AAGTAATACTACCAAACCATTGATTAATACAAATTCCCCACCCAATGAAC
ATTTAAAAACCAATAATCATCGAGTTATCACATCGAAACCCCCTCAAATC
CTACCTGCTATGAGCAATTCAGCTTCTTCCAATATATTGAAAACTCCAAC
ACTAGCAGCTACACTGATAGGAATGCAGCCATCAAAAATGGCGACAAACA
CCACAGAAACCCATAGTGGTACTGGTATCGGCACAGGAGGTCGAGGGGTT
CGACGGAATTCCCATAATGCTATTGAGAAACGATACCGATTAAGTATCAA
TGATAAAATTGACGAACTGCGCCATATGCTTTTCCTAGGCGACGATTCCA
AGATGAACAAATCAAATGTTCTTAAAAAAGCTATTGAGCGAATAAAATGT
TTGGAAGATGAAAATAATGCTTTGAAACATGAAAATTACAATCTACGCAT
ATCAAAAAATTTGCCAATTATTACTAACAGAAACAGCGTCGAAAGTCTAA
ATCAAACCGGCAGCAGTCCATCATCCAATAATTCCGATGGCGGACATTCT
ATTGAAAATAGTCCCAGCTCTTCCTCCATGCATTCATCAAGTGTAAATTC
AGGTTGTTTATTCATAAATTCCGTAGAAAAAAGTGAGAAGAACGTATCCA
ATTCCAATAGAGGAACTAAGCGCCCATTGATATATAACTTAAATAACAAT
AATGATAATTCCACGCATATTGTAAAAAATGAAAAACTAGCCAGACTCTT
ACTCGATCATAAAGATGAATATTCAAATAAAAGTTATGAAGTACAAGCAA
ATCGAAATTCCAAAAAGTTACATTCTTCAAATGTGCCAGGATTTCTTTTA
TGTGGGATAGCATTATTTGTTGTTTCATTCCAACCATTCGATTTTCTTGT
GAGAAAATATCAATCCAAACATTCTACAATAACGGGTGGTCGTCAATTAT
TGTTTTCAAATCATGGAGATTTTAGTGGCCAAGGATATTTATTCGCATTG
TTTCTAACTTTGGCACATTGGTCTGTTGCATTTATTTTAGTATATGGATC
TGCAAGTAATCGATTCTTTCTGAAAAAGATGATTGCATTGTTGTTGAAAA
AACTCCAATCGTCCCTTTGGTCCGTATGTCTTATTAAAACGGCTAATCTA
ACGCATAATTTGGTGGAGTTAAAAATAGATTTAAAAGAAAATTATCAAAA
TCACAACTTATTTCAATCACGCATTGAAAGTCTGGCAGAGGAATATGGAT
GCTCATGCCAAGTCAATCCATTCATGAAAGTTTTTCAATTCACTGCTTAT
ATTTTGAATTTCTTCACCAATTTTTTACAAATTATTTTGAACCAAAAAAA
GTGTTTAAGTGAAACTCGTAAAATCAATGTGTATATCTTGACTGTTATCA
TCGATCAGGCAACTATCGGTCAACTCTGTTATTCGAAATTCGAAATATTT
TGGTACAAAATTTTGTTCTTTTTATCATCATGGAATCTAGAAATCAACGA
TGAAATTCTATTTTCAAAATTTACGTTTGCTCTTTCTATTTCCACTGGAT
TCATTCGTCGATATTTCTTAAAAAGGATTTTCGAAACTGCTAATCGTCAT
CAAGATTTAGTGTCCTGTAGATTACAATTGTTTCTTTTAAATAATAATTT
ACAGGAAATGCTAATTAAAACAAGTCCTCAGAGTTTAATGAATAAATTTG
ATTTACAAAACATGGATAAAAGGATAGATCTAGATAAACAGAGCTTGATG
AATTATTATTTCATGAATTATGCTCAAGACACTATCGAATCAGCTTCCCA
AATTATTCTCGATGGAAAACCACCCCATAATGACATTTTAAATCAACTGA
AAGATATTATCAATTATTCACCGGCTATTCTTAATGACACTGAGTCTACT
TACTTTAGTCTTTGGTGCTGCCTACTTCTACAGTTGCTCAAAGATCAAAA
TAGCCAACATATTAATAAAGTGGTGACGAAATTGATCAGTCATTATTCGT
CATTGACAAAAATGGTTGTTATTAAAAATTCAAATGATTCGATTAAGTCA
TCATTTGGAATTTTACAATTATTATTATCAACACTTCAACTCTGTGGAAA
TGAAGAAGACAAATTGTATCATGAAATAAATATAAAATGTATGGAAAGTA
TTACACAAAGTGCGAACATGAATGTTGTTTTCCGAATGATATTGAGGTTA
TCTCTAACGCGAATTGTTCAAAGTCTTAAAATGTGTAATTCAAATACTTT
TACTAATATCAGTAATATTGTCTACTATTGTAACGCTTATTTCAAGCAGC
TTAGTAAACATTATAAGCACCAGTCAGAAATTGAAGTAGAAATGATGTCT
GAGTTCGAAGCATTATTTCATAATCTCTGTCAATTAAATCCCATGAAATG
TATGGCGTTAAAGTTACAAGAAAAAGACAGCACTAAAAGTGTTTCCAGCA
GTCCATTAAAAAAACCGAATGACAATTGTTTTAGAATAACTGATTTTTTA
TCTTTGGAAAGAGATTCTAAATTAAGATCTCATTGACAATTTATTCATTT
TGACTACATATAATATAGACTTCCTGTTTGATATTTGTTTCTATTAATGA
TAATTTTAGGTTCATAATTTATCAGAAATTGCTTTGAAGTTATAAATATA
TATTATAATAATTTTATTAATAAATGTTTCGGTATTTAACAA

protein sequence of SMED30026172-orf-1

>SMED30026172-orf-1 ID=SMED30026172-orf-1|Name=SMED30026172-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=979bp
MDDILNLTDDDISNFLDIPNDDEIFRELDSLEFTNEIENDLIYEYEIEKH
LSNGDTYKQYTDPYSSHENNVNYVNNNVYVNNYGNIKPNCINVSKNEVHD
NAEQKLMIIRELLDSDIHDSTNGIISALQNNNHRSNTTKPLINTNSPPNE
HLKTNNHRVITSKPPQILPAMSNSASSNILKTPTLAATLIGMQPSKMATN
TTETHSGTGIGTGGRGVRRNSHNAIEKRYRLSINDKIDELRHMLFLGDDS
KMNKSNVLKKAIERIKCLEDENNALKHENYNLRISKNLPIITNRNSVESL
NQTGSSPSSNNSDGGHSIENSPSSSSMHSSSVNSGCLFINSVEKSEKNVS
NSNRGTKRPLIYNLNNNNDNSTHIVKNEKLARLLLDHKDEYSNKSYEVQA
NRNSKKLHSSNVPGFLLCGIALFVVSFQPFDFLVRKYQSKHSTITGGRQL
LFSNHGDFSGQGYLFALFLTLAHWSVAFILVYGSASNRFFLKKMIALLLK
KLQSSLWSVCLIKTANLTHNLVELKIDLKENYQNHNLFQSRIESLAEEYG
CSCQVNPFMKVFQFTAYILNFFTNFLQIILNQKKCLSETRKINVYILTVI
IDQATIGQLCYSKFEIFWYKILFFLSSWNLEINDEILFSKFTFALSISTG
FIRRYFLKRIFETANRHQDLVSCRLQLFLLNNNLQEMLIKTSPQSLMNKF
DLQNMDKRIDLDKQSLMNYYFMNYAQDTIESASQIILDGKPPHNDILNQL
KDIINYSPAILNDTESTYFSLWCCLLLQLLKDQNSQHINKVVTKLISHYS
SLTKMVVIKNSNDSIKSSFGILQLLLSTLQLCGNEEDKLYHEINIKCMES
ITQSANMNVVFRMILRLSLTRIVQSLKMCNSNTFTNISNIVYYCNAYFKQ
LSKHYKHQSEIEVEMMSEFEALFHNLCQLNPMKCMALKLQEKDSTKSVSS
SPLKKPNDNCFRITDFLSLERDSKLRSH*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0000103	central nervous system
PLANA:0000120	progenitor cell
PLANA:0000121	stem cell
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR036638	HLH_DNA-bd_sf
IPR000299	FERM_domain
IPR011598	bHLH_dom

Vocabulary: **molecular function**
Term	Definition
GO:0046983	protein dimerization activity

Vocabulary: **cellular component**
Term	Definition
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 251..278
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 199..218
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 300..329
None	No IPR available	PANTHER	PTHR46062	FAMILY NOT NAMED	coord: 126..483
None	No IPR available	TMHMM	TMhelix		coord: 412..434
None	No IPR available	TMHMM	TMhelix		coord: 463..485
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	SMART	SM00353	finulus	coord: 223..274 e-value: 2.6E-10 score: 50.3
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	PFAM	PF00010	HLH	coord: 218..269 e-value: 6.1E-14 score: 51.7
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	PROSITE	PS50888	BHLH	coord: 217..268 score: 14.24
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	CDD	cd00083	HLH	coord: 221..272 e-value: 8.32876E-9 score: 50.6755
IPR036638	Helix-loop-helix DNA-binding domain superfamily	GENE3D	G3DSA:4.10.280.10		coord: 214..288 e-value: 1.9E-18 score: 68.3
IPR036638	Helix-loop-helix DNA-binding domain superfamily	SUPERFAMILY	SSF47459	HLH, helix-loop-helix DNA-binding domain	coord: 212..283

Main menu

srebp protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Owlery

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