DNL-type domain-containing protein

Overview


Name	DNL-type domain-containing protein
Smed ID	SMED30026022
Length (bp)	467

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of DNL-type domain-containing protein (SMED30026022) t-SNE clustered cells

Violin plots show distribution of expression levels for DNL-type domain-containing protein (SMED30026022) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNL-type domain-containing protein (SMED30026022) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNL-type domain-containing protein (SMED30026022) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30026022

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30026022	SMESG000066940.1	SmedASXL_079461	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
neoblast	SMED30026022	SMESG000066940.1	dd_Smed_v4_2816_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30026022	SMESG000066940.1	dd_Smed_v4_2816_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of DNL-type domain-containing protein vs. Ensembl Human
Match: DNLZ (DNL-type zinc finger [Source:HGNC Symbol;Acc:HGNC:33879])

HSP 1 Score: 68.1662 bits (165), Expect = 1.940e-14
Identity = 30/66 (45.45%), Postives = 44/66 (66.67%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLIN 398
            EA    + +TCK C T+  K  SK+AY +GVVI+ C GC++ H++ADNLGW +D + K  IE ++ 
Sbjct:   65 EAAHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPGCQNHHIIADNLGWFSDLNGKRNIEEILT 130

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Celegans
Match: F53A3.7 (pep chromosome:WBcel235:III:1951526:1952032:1 gene:WBGene00018723.1 transcript:F53A3.7.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F53A3.7)

HSP 1 Score: 68.5514 bits (166), Expect = 1.714e-15
Identity = 30/65 (46.15%), Postives = 45/65 (69.23%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVK-KTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            + P+  + +TCK CN++   KTF+K +YEKGVVI+ C GC + H++ADN+GW  D K   IE+ +
Sbjct:   31 QEPQLSLSYTCKVCNSREGPKTFAKSSYEKGVVIVTCSGCHNHHIIADNIGWFEDFKGKNIEDHL 95

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Fly
Match: CG12379 (gene:FBgn0030676 transcript:FBtr0273278)

HSP 1 Score: 70.8626 bits (172), Expect = 8.638e-16
Identity = 34/65 (52.31%), Postives = 46/65 (70.77%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            EA  + I +TCK C T+  KT SK+AY++GVVI+ C+GC + HL+ADNL W TD D K  IE ++
Sbjct:   89 EAKMQLI-YTCKVCQTRNMKTISKLAYQRGVVIVTCEGCSNHHLIADNLNWFTDLDGKRNIEEIL 152

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Fly
Match: CG8206 (gene:FBgn0030679 transcript:FBtr0346187)

HSP 1 Score: 58.5362 bits (140), Expect = 5.694e-11
Identity = 26/50 (52.00%), Postives = 33/50 (66.00%), Query Frame = 3

Query:  213 RKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWIT 362
            R  + + CK CNT+  KT S+ AY  GVVI++CDGC   HL+ DNLG  T
Sbjct:  101 RMELVYRCKLCNTRNTKTISEEAYYSGVVILQCDGCAVDHLIKDNLGLFT 150

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Fly
Match: CG8206 (gene:FBgn0030679 transcript:FBtr0074085)

HSP 1 Score: 58.5362 bits (140), Expect = 5.694e-11
Identity = 26/50 (52.00%), Postives = 33/50 (66.00%), Query Frame = 3

Query:  213 RKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWIT 362
            R  + + CK CNT+  KT S+ AY  GVVI++CDGC   HL+ DNLG  T
Sbjct:  101 RMELVYRCKLCNTRNTKTISEEAYYSGVVILQCDGCAVDHLIKDNLGLFT 150

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Zebrafish
Match: dnlz (DNL-type zinc finger [Source:NCBI gene;Acc:791166])

HSP 1 Score: 63.929 bits (154), Expect = 6.628e-13
Identity = 28/60 (46.67%), Postives = 43/60 (71.67%), Query Frame = 3

Query:  219 YIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            ++ +TCK C+T+  K  SK+AY KGVVI+ C GC++ H++ADNL W +D + K  IE ++
Sbjct:   80 HLVYTCKVCSTRSMKKISKLAYHKGVVIVTCPGCKNHHVIADNLKWFSDLEGKRNIEEIL 139

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Xenopus
Match: kifc1 (kinesin family member C1 [Source:Xenbase;Acc:XB-GENE-489355])

HSP 1 Score: 70.0922 bits (170), Expect = 3.923e-15
Identity = 30/60 (50.00%), Postives = 45/60 (75.00%), Query Frame = 3

Query:  219 YIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            ++ +TCK C+T+  KT SK AY KGVVI++C GC++ H++ADNLGW +D + K  IE ++
Sbjct:   80 HLIYTCKVCSTRSNKTISKGAYHKGVVIVKCPGCKNHHIIADNLGWFSDLEGKRNIEEIL 139

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Mouse
Match: Dnlz (DNL-type zinc finger [Source:MGI Symbol;Acc:MGI:106559])

HSP 1 Score: 63.929 bits (154), Expect = 5.829e-13
Identity = 30/65 (46.15%), Postives = 43/65 (66.15%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDK-KWKIENLI 395
            EA    + +TCK C T+  K  SK+AY +GVVI+ C GC++ H++ADNL W +D K K  IE ++
Sbjct:   69 EADHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPGCQNHHIIADNLSWFSDLKGKRNIEEIL 133

[Close]

BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q0IH40|DNLZ_XENLA (DNL-type zinc finger protein OS=Xenopus laevis OX=8355 GN=dnlz PE=2 SV=1)

HSP 1 Score: 73.559 bits (179), Expect = 1.334e-15
Identity = 32/57 (56.14%), Postives = 43/57 (75.44%), Query Frame = 3

Query:  228 FTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            +TCK C T+  KT SKVAY KGVVI+RC GCE+ H++ADNLGW +D + +  IE ++
Sbjct:   86 YTCKVCATRSSKTISKVAYHKGVVIVRCPGCENHHIIADNLGWFSDLEGRRNIEEIL 142

[Close]

BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5SXM8|DNLZ_HUMAN (DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 9.316e-14
Identity = 30/66 (45.45%), Postives = 44/66 (66.67%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLIN 398
            EA    + +TCK C T+  K  SK+AY +GVVI+ C GC++ H++ADNLGW +D + K  IE ++ 
Sbjct:   65 EAAHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPGCQNHHIIADNLGWFSDLNGKRNIEEILT 130

[Close]

BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9D113|DNLZ_MOUSE (DNL-type zinc finger protein OS=Mus musculus OX=10090 GN=Dnlz PE=1 SV=1)

HSP 1 Score: 63.929 bits (154), Expect = 4.077e-12
Identity = 30/65 (46.15%), Postives = 43/65 (66.15%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDK-KWKIENLI 395
            EA    + +TCK C T+  K  SK+AY +GVVI+ C GC++ H++ADNL W +D K K  IE ++
Sbjct:   69 EADHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPGCQNHHIIADNLSWFSDLKGKRNIEEIL 133

[Close]

BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
Match: sp|A1L1P7|DNLZ_DANRE (DNL-type zinc finger protein OS=Danio rerio OX=7955 GN=dnlz PE=2 SV=1)

HSP 1 Score: 63.929 bits (154), Expect = 5.175e-12
Identity = 28/60 (46.67%), Postives = 43/60 (71.67%), Query Frame = 3

Query:  219 YIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            ++ +TCK C+T+  K  SK+AY KGVVI+ C GC++ H++ADNL W +D + K  IE ++
Sbjct:   82 HLVYTCKVCSTRSMKKISKLAYHKGVVIVTCPGCKNHHVIADNLKWFSDLEGKRNIEEIL 141

[Close]

BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
Match: sp|P42844|ZIM17_YEAST (Mitochondrial protein import protein ZIM17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ZIM17 PE=1 SV=2)

HSP 1 Score: 62.003 bits (149), Expect = 2.038e-11
Identity = 33/68 (48.53%), Postives = 42/68 (61.76%), Query Frame = 3

Query:  192 FKFDEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            FK D+ P+  I FTCK CNT+   T SK AYEKG V+I C  C+  HL+AD+L  I  D    +E L+
Sbjct:   62 FKVDK-PKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPHCKVRHLIADHLK-IFHDHHVTVEQLM 127

[Close]

BLAST of DNL-type domain-containing protein vs. TrEMBL
Match: A0A183VWF2 (DNL-type domain-containing protein OS=Trichobilharzia regenti OX=157069 GN=TRE_LOCUS4808 PE=4 SV=1)

HSP 1 Score: 95.5153 bits (236), Expect = 7.647e-23
Identity = 43/64 (67.19%), Postives = 52/64 (81.25%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
               + YIEFTCK C+T+  K FSK+AYEKGVVIIRCDGC+SLHL+ADNLGWI  DK WK+E+ +
Sbjct:    3 STGKMYIEFTCKKCSTRSSKYFSKLAYEKGVVIIRCDGCQSLHLIADNLGWI-KDKHWKLEDFV 65

[Close]

BLAST of DNL-type domain-containing protein vs. TrEMBL
Match: Q5D957 (Mitochondrial protein import protein OS=Schistosoma japonicum OX=6182 GN=EWB00_008926 PE=2 SV=1)

HSP 1 Score: 95.5153 bits (236), Expect = 7.214e-22
Identity = 45/66 (68.18%), Postives = 54/66 (81.82%), Query Frame = 3

Query:  201 DEAPRK-YIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            +E  RK YIEFTCK C T+  K FSK+AYEKG+VIIRCDGC+SLHL+ADNLGWI  DK WK+E+ +
Sbjct:   88 NEIKRKMYIEFTCKKCTTRSGKYFSKLAYEKGIVIIRCDGCQSLHLIADNLGWI-KDKHWKLEDCV 152

[Close]

BLAST of DNL-type domain-containing protein vs. TrEMBL
Match: A0A5K4FAB5 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 1.810e-21
Identity = 42/61 (68.85%), Postives = 51/61 (83.61%), Query Frame = 3

Query:  213 RKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            + YIEFTCK C T+  K FSK+AYEKG+VIIRCDGC+SLHL+ADNLGWI  DK WK+E+ +
Sbjct:   86 KMYIEFTCKKCATRSSKYFSKLAYEKGIVIIRCDGCQSLHLIADNLGWI-KDKHWKLEDCV 145

[Close]

BLAST of DNL-type domain-containing protein vs. TrEMBL
Match: A0A4E0RGE9 (To Mitochondrial protein import protein ZIM17 OS=Fasciola hepatica OX=6192 GN=D915_008660 PE=4 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 5.378e-21
Identity = 41/65 (63.08%), Postives = 53/65 (81.54%), Query Frame = 3

Query:  201 DEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            D + + YIEFTCK CN + KK FSK AY  G+VIIRCDGCE+LHL+ADNLGWI DD +W++E+++
Sbjct:   72 DVSGKMYIEFTCKKCNHRSKKYFSKKAYLHGIVIIRCDGCENLHLIADNLGWIKDD-RWRLEDVV 135

[Close]

BLAST of DNL-type domain-containing protein vs. TrEMBL
Match: A0A504YHQ5 (DNL-type zinc finger protein OS=Fasciola gigantica OX=46835 GN=FGIG_01406 PE=4 SV=1)

HSP 1 Score: 91.2781 bits (225), Expect = 1.726e-20
Identity = 40/65 (61.54%), Postives = 53/65 (81.54%), Query Frame = 3

Query:  201 DEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            D + + YIEFTCK CN + KK FSK AY  G+VIIRCDGCE+LHL+ADN+GWI DD +W++E+++
Sbjct:   72 DVSGKMYIEFTCKKCNHRSKKYFSKKAYLHGIVIIRCDGCENLHLIADNVGWIKDD-RWRLEDVV 135

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Cavefish
Match: dnlz (DNL-type zinc finger [Source:NCBI gene;Acc:103030185])

HSP 1 Score: 67.781 bits (164), Expect = 2.024e-14
Identity = 29/60 (48.33%), Postives = 43/60 (71.67%), Query Frame = 3

Query:  219 YIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            ++ +TCK C+T+  K  SK+AY KGVVI+ C GC + H++ADNLGW +D + K  IE ++
Sbjct:   84 HLVYTCKVCSTRSMKKISKMAYHKGVVIVTCPGCSNHHIIADNLGWFSDLEGKRNIEEIL 143

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Yeast
Match: ZIM17 (Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins [Source:SGD;Acc:S000005254])

HSP 1 Score: 62.003 bits (149), Expect = 2.935e-13
Identity = 33/68 (48.53%), Postives = 42/68 (61.76%), Query Frame = 3

Query:  192 FKFDEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            FK D+ P+  I FTCK CNT+   T SK AYEKG V+I C  C+  HL+AD+L  I  D    +E L+
Sbjct:   62 FKVDK-PKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPHCKVRHLIADHLK-IFHDHHVTVEQLM 127

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Nematostella
Match: EDO44282 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWB0])

HSP 1 Score: 69.707 bits (169), Expect = 1.205e-16
Identity = 30/56 (53.57%), Postives = 45/56 (80.36%), Query Frame = 3

Query:  228 FTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLI 395
            FTCK C+T+  KT SK+AY KGVVI++C GC++ HL+ADN+GW  ++K+  IE+++
Sbjct:    5 FTCKVCDTRSTKTISKLAYNKGVVIVKCPGCDNNHLIADNMGWFYNEKR-NIEDIL 59

[Close]

BLAST of DNL-type domain-containing protein vs. Ensembl Medaka
Match: dnlz (DNL-type zinc finger [Source:NCBI gene;Acc:791166])

HSP 1 Score: 70.0922 bits (170), Expect = 3.233e-15
Identity = 30/65 (46.15%), Postives = 46/65 (70.77%), Query Frame = 3

Query:  204 EAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITD-DKKWKIENLI 395
            ++   ++ +TCK C+T+  +  SKVAY KGVVI+ C GCE+ H++ADNLGW +D + K  IE ++
Sbjct:   92 QSTHYHLVYTCKVCSTRSTQKISKVAYHKGVVIVTCPGCENHHIIADNLGWFSDLEGKRNIEEIL 156

[Close]

BLAST of DNL-type domain-containing protein vs. Planmine SMEST
Match: SMESG000066940.1 (SMESG000066940.1)

HSP 1 Score: 230.72 bits (587), Expect = 3.048e-79
Identity = 125/126 (99.21%), Postives = 126/126 (100.00%), Query Frame = 3

Query:   45 MKLIKYCVTYCNKFVFPVKLNLFQIKQFKYLIPPKRFXXXXXXXXXXXXFKFDEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLINKPKSDDEN 422
            MKLIKYCVTYCNKFVFPVKLNLFQIKQFKYLIPPKRFSSDST+NSNNLSFKFDEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLINKPKSDDEN
Sbjct:    1 MKLIKYCVTYCNKFVFPVKLNLFQIKQFKYLIPPKRFSSDSTTNSNNLSFKFDEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVADNLGWITDDKKWKIENLINKPKSDDEN 126

The following BLAST results are available for this feature:

BLAST of DNL-type domain-containing protein vs. Ensembl Human
BLAST of DNL-type domain-containing protein vs. Ensembl Celegans
BLAST of DNL-type domain-containing protein vs. Ensembl Fly
BLAST of DNL-type domain-containing protein vs. Ensembl Zebrafish
BLAST of DNL-type domain-containing protein vs. Ensembl Xenopus
BLAST of DNL-type domain-containing protein vs. Ensembl Mouse
BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
BLAST of DNL-type domain-containing protein vs. TrEMBL
BLAST of DNL-type domain-containing protein vs. Ensembl Cavefish
BLAST of DNL-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of DNL-type domain-containing protein vs. Ensembl Yeast
BLAST of DNL-type domain-containing protein vs. Ensembl Nematostella
BLAST of DNL-type domain-containing protein vs. Ensembl Medaka
BLAST of DNL-type domain-containing protein vs. Planmine SMEST

BLAST of DNL-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
DNLZ	1.940e-14	45.45	DNL-type zinc finger [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
F53A3.7	1.714e-15	46.15	pep chromosome:WBcel235:III:1951526:1952032:1 gene...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CG12379	8.638e-16	52.31	gene:FBgn0030676 transcript:FBtr0273278	[more]
CG8206	5.694e-11	52.00	gene:FBgn0030679 transcript:FBtr0346187	[more]
CG8206	5.694e-11	52.00	gene:FBgn0030679 transcript:FBtr0074085	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
dnlz	6.628e-13	46.67	DNL-type zinc finger [Source:NCBI gene;Acc:791166]	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
kifc1	3.923e-15	50.00	kinesin family member C1 [Source:Xenbase;Acc:XB-GE...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Dnlz	5.829e-13	46.15	DNL-type zinc finger [Source:MGI Symbol;Acc:MGI:10...	[more]

BLAST of DNL-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q0IH40\|DNLZ_XENLA	1.334e-15	56.14	DNL-type zinc finger protein OS=Xenopus laevis OX=...	[more]
sp\|Q5SXM8\|DNLZ_HUMAN	9.316e-14	45.45	DNL-type zinc finger protein OS=Homo sapiens OX=96...	[more]
sp\|Q9D113\|DNLZ_MOUSE	4.077e-12	46.15	DNL-type zinc finger protein OS=Mus musculus OX=10...	[more]
sp\|A1L1P7\|DNLZ_DANRE	5.175e-12	46.67	DNL-type zinc finger protein OS=Danio rerio OX=795...	[more]
sp\|P42844\|ZIM17_YEAST	2.038e-11	48.53	Mitochondrial protein import protein ZIM17 OS=Sacc...	[more]

BLAST of DNL-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A183VWF2	7.647e-23	67.19	DNL-type domain-containing protein OS=Trichobilhar...	[more]
Q5D957	7.214e-22	68.18	Mitochondrial protein import protein OS=Schistosom...	[more]
A0A5K4FAB5	1.810e-21	68.85	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
A0A4E0RGE9	5.378e-21	63.08	To Mitochondrial protein import protein ZIM17 OS=F...	[more]
A0A504YHQ5	1.726e-20	61.54	DNL-type zinc finger protein OS=Fasciola gigantica...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
dnlz	2.024e-14	48.33	DNL-type zinc finger [Source:NCBI gene;Acc:1030301...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of DNL-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
ZIM17	2.935e-13	48.53	Protein co-chaperone with a zinc finger motif; ess...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO44282	1.205e-16	53.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of DNL-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
dnlz	3.233e-15	46.15	DNL-type zinc finger [Source:NCBI gene;Acc:791166]	[more]

BLAST of DNL-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000066940.1	3.048e-79	99.21	SMESG000066940.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30026022 ID=SMED30026022|Name=DNL-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=467bp
AGAATGTTACAAATTTAAAATTTTATTAATGCTCAATATTGAGCATGAAA
TTAATAAAATATTGTGTAACTTATTGCAACAAGTTTGTTTTCCCTGTCAA
ATTAAATCTTTTTCAAATTAAACAATTTAAATATTTAATTCCACCTAAAA
GATTTAGCTCTGATTCTACTTCTAATTCAAATAATCTTAGCTTCAAATTT
GACGAAGCTCCCAGGAAGTATATTGAATTCACGTGTAAAAGCTGTAATAC
AAAAGTTAAAAAAACTTTTTCCAAAGTAGCTTATGAAAAAGGAGTGGTAA
TAATTAGATGTGATGGGTGTGAATCATTGCATTTAGTGGCTGATAATTTA
GGTTGGATTACAGACGATAAGAAATGGAAAATAGAAAATCTTATAAACAA
GCCCAAGTCAGATGATGAAAATTGATTTTATTAAATAAATGAGATTGTTG
GAGTCTTTTAAAAAAAA

protein sequence of SMED30026022-orf-1

>SMED30026022-orf-1 ID=SMED30026022-orf-1|Name=SMED30026022-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=127bp
MKLIKYCVTYCNKFVFPVKLNLFQIKQFKYLIPPKRFSSDSTSNSNNLSF
KFDEAPRKYIEFTCKSCNTKVKKTFSKVAYEKGVVIIRCDGCESLHLVAD
NLGWITDDKKWKIENLINKPKSDDEN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000429	neoblast
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR024158	Mt_import_TIM15
IPR007853	Znf_DNL-typ

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR007853	Zinc finger, DNL-type	PFAM	PF05180	zf-DNL	coord: 60..119 e-value: 1.5E-25 score: 88.8
IPR007853	Zinc finger, DNL-type	PROSITE	PS51501	ZF_DNL	coord: 53..126 score: 15.913
IPR024158	Mitochondrial import protein TIM15	PANTHER	PTHR20922	UNCHARACTERIZED	coord: 42..118
None	No IPR available	PANTHER	PTHR20922:SF13	DNL-TYPE ZINC FINGER PROTEIN	coord: 42..118

Main menu

DNL-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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