SPRY domain containing SOCS box protein-1

Overview
NameSPRY domain containing SOCS box protein-1 (AFJ24733.1)
Smed IDSMED30025986
Length (bp)1436
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SPRY domain containing SOCS box protein-1 (SMED30025986) t-SNE clustered cells

Violin plots show distribution of expression levels for SPRY domain containing SOCS box protein-1 (SMED30025986) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025986

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X2 cellSMED30025986SMESG000053741.1 SmedASXL_006584SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Human
Match: SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4 [Source:HGNC Symbol;Acc:HGNC:30630])

HSP 1 Score: 237.269 bits (604), Expect = 1.293e-74
Identity = 136/269 (50.56%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQ---TYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL QL+D+P     +QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRGK+G  RG H W+I+W  R+RGTHAVVGV T  APLH  GY +L+G   ESWGWD+ R +L H    D ++Q    YP  +             P+    + +S+ V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCEVTM ++  L+P PLPL+ LCR  IR  L     R  LQ            I  L +P+ LK YL+
Sbjct:   34 PARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYH----DGKNQPGVAYPAFLG------------PDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSAL----GRQRLQ-----------DISSLPLPQSLKNYLQ 271
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Human
Match: SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:30628])

HSP 1 Score: 229.18 bits (583), Expect = 2.142e-71
Identity = 130/269 (48.33%), Postives = 169/269 (62.83%), Query Frame = 2 
Query:  470 DKC-PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGRERLG-----------EIHTLPLPASLKAYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Human
Match: SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:30628])

HSP 1 Score: 229.18 bits (583), Expect = 2.142e-71
Identity = 130/269 (48.33%), Postives = 169/269 (62.83%), Query Frame = 2 
Query:  470 DKC-PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGRERLG-----------EIHTLPLPASLKAYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Human
Match: SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:30628])

HSP 1 Score: 229.18 bits (583), Expect = 2.142e-71
Identity = 130/269 (48.33%), Postives = 169/269 (62.83%), Query Frame = 2 
Query:  470 DKC-PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGRERLG-----------EIHTLPLPASLKAYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Human
Match: SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2 [Source:HGNC Symbol;Acc:HGNC:29522])

HSP 1 Score: 192.2 bits (487), Expect = 2.753e-57
Identity = 101/203 (49.75%), Postives = 117/203 (57.64%), Query Frame = 2 
Query:  476 CPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEV 1084
            CP  L +L+  P      Q  + WNP D S NI+VK    L   R PVAQSTD  RGK G++RG H W I W L +RGTHAVVGV T  APL    Y +L+G   ESWGWDI R KL H QS       YP     +              +EV E + V+LDMEEGTL +   G YLG AF GLKGRTLYPA+SAVWG C+V
Sbjct:   25 CPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYH-QSKGPGAPQYPAGTQGE-------------QLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQV 212
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Celegans
Match: spsb-1 (SPSB (SPry and Socs Box) family [Source:UniProtKB/TrEMBL;Acc:U4PM56])

HSP 1 Score: 211.46 bits (537), Expect = 4.081e-64
Identity = 122/265 (46.04%), Postives = 164/265 (61.89%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R  ++M +      +Q  ++WNP D S+NI VK  D  T HRHPVAQSTD IRGK+G++RGFH+W+I+W  R+RGTHAVVGV TK+APLH  GY +LIG T+ES+GWDI R++  H  S       YP   + D+ ++ D               + +LDM+EG ++F  D ++LGVAF  LKG+TLYP ++AVWGHCE++M +L SL P PL L  LC    R+ +RI +     Q +D         I+QL IP  LK YL
Sbjct:  111 PDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRE-CHHDSKHTMTWRYPFSNSRDVYNVPD-------------KFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELC----RRRVRIEMG---AQPED--------HIEQLMIPPILKRYL 346
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Celegans
Match: spsb-1 (SPSB (SPry and Socs Box) family [Source:UniProtKB/TrEMBL;Acc:U4PM56])

HSP 1 Score: 211.46 bits (537), Expect = 4.081e-64
Identity = 122/265 (46.04%), Postives = 164/265 (61.89%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R  ++M +      +Q  ++WNP D S+NI VK  D  T HRHPVAQSTD IRGK+G++RGFH+W+I+W  R+RGTHAVVGV TK+APLH  GY +LIG T+ES+GWDI R++  H  S       YP   + D+ ++ D               + +LDM+EG ++F  D ++LGVAF  LKG+TLYP ++AVWGHCE++M +L SL P PL L  LC    R+ +RI +     Q +D         I+QL IP  LK YL
Sbjct:  111 PDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRE-CHHDSKHTMTWRYPFSNSRDVYNVPD-------------KFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELC----RRRVRIEMG---AQPED--------HIEQLMIPPILKRYL 346
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Celegans
Match: spsb-1 (SPSB (SPry and Socs Box) family [Source:UniProtKB/TrEMBL;Acc:U4PM56])

HSP 1 Score: 211.46 bits (537), Expect = 4.748e-64
Identity = 122/265 (46.04%), Postives = 164/265 (61.89%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R  ++M +      +Q  ++WNP D S+NI VK  D  T HRHPVAQSTD IRGK+G++RGFH+W+I+W  R+RGTHAVVGV TK+APLH  GY +LIG T+ES+GWDI R++  H  S       YP   + D+ ++ D               + +LDM+EG ++F  D ++LGVAF  LKG+TLYP ++AVWGHCE++M +L SL P PL L  LC    R+ +RI +     Q +D         I+QL IP  LK YL
Sbjct:  113 PDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRE-CHHDSKHTMTWRYPFSNSRDVYNVPD-------------KFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELC----RRRVRIEMG---AQPED--------HIEQLMIPPILKRYL 348
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Celegans
Match: spsb-1 (SPSB (SPry and Socs Box) family [Source:UniProtKB/TrEMBL;Acc:U4PM56])

HSP 1 Score: 212.231 bits (539), Expect = 1.402e-63
Identity = 122/265 (46.04%), Postives = 164/265 (61.89%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R  ++M +      +Q  ++WNP D S+NI VK  D  T HRHPVAQSTD IRGK+G++RGFH+W+I+W  R+RGTHAVVGV TK+APLH  GY +LIG T+ES+GWDI R++  H  S       YP   + D+ ++ D               + +LDM+EG ++F  D ++LGVAF  LKG+TLYP ++AVWGHCE++M +L SL P PL L  LC    R+ +RI +     Q +D         I+QL IP  LK YL
Sbjct:  174 PDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRE-CHHDSKHTMTWRYPFSNSRDVYNVPD-------------KFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELC----RRRVRIEMG---AQPED--------HIEQLMIPPILKRYL 409
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Celegans
Match: spsb-1 (SPSB (SPry and Socs Box) family [Source:UniProtKB/TrEMBL;Acc:U4PM56])

HSP 1 Score: 211.846 bits (538), Expect = 1.734e-63
Identity = 122/265 (46.04%), Postives = 164/265 (61.89%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R  ++M +      +Q  ++WNP D S+NI VK  D  T HRHPVAQSTD IRGK+G++RGFH+W+I+W  R+RGTHAVVGV TK+APLH  GY +LIG T+ES+GWDI R++  H  S       YP   + D+ ++ D               + +LDM+EG ++F  D ++LGVAF  LKG+TLYP ++AVWGHCE++M +L SL P PL L  LC    R+ +RI +     Q +D         I+QL IP  LK YL
Sbjct:  172 PDRFDRIMQMTKPDQFIQEQHSWNPEDRSLNIFVKDEDKFTFHRHPVAQSTDCIRGKMGYSRGFHVWQIEWPERQRGTHAVVGVATKNAPLHAAGYTALIGTTDESYGWDITRRE-CHHDSKHTMTWRYPFSNSRDVYNVPD-------------KFYCILDMDEGYMAFATDDEFLGVAFRNLKGKTLYPIVAAVWGHCEISMRYLGSLEPEPLSLSELC----RRRVRIEMG---AQPED--------HIEQLMIPPILKRYL 407
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Fly
Match: gus (gene:FBgn0026238 transcript:FBtr0309850)

HSP 1 Score: 233.417 bits (594), Expect = 2.198e-73
Identity = 133/265 (50.19%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R+  L+D+P  +  +QL ++WN  D S+NI VK  D LT HRHPVAQSTD IRGK+G  +G H+W I W  R+RGTHAVVGVCT DAPLH  GY SL+G TE+SWGWD+ R KL H  S +    TYP I+ +D   L            V +   V LDM+EGTLSFI D QYLG+AF GL+G+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+     + R           +L   I QL +P  +K YL
Sbjct:   36 PARIDILLDMPPASRDLQLKHSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSVGYQSLVGSTEQSWGWDLGRNKLYH-DSKNCAGVTYPAILKNDEAFL------------VPDKFLVALDMDEGTLSFIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQ----KIGRT----------NLEEHIQQLQLPLSMKTYL 273
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Fly
Match: gus (gene:FBgn0026238 transcript:FBtr0309849)

HSP 1 Score: 233.417 bits (594), Expect = 2.198e-73
Identity = 133/265 (50.19%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R+  L+D+P  +  +QL ++WN  D S+NI VK  D LT HRHPVAQSTD IRGK+G  +G H+W I W  R+RGTHAVVGVCT DAPLH  GY SL+G TE+SWGWD+ R KL H  S +    TYP I+ +D   L            V +   V LDM+EGTLSFI D QYLG+AF GL+G+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+     + R           +L   I QL +P  +K YL
Sbjct:   36 PARIDILLDMPPASRDLQLKHSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSVGYQSLVGSTEQSWGWDLGRNKLYH-DSKNCAGVTYPAILKNDEAFL------------VPDKFLVALDMDEGTLSFIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQ----KIGRT----------NLEEHIQQLQLPLSMKTYL 273
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Fly
Match: gus (gene:FBgn0026238 transcript:FBtr0309852)

HSP 1 Score: 233.417 bits (594), Expect = 2.198e-73
Identity = 133/265 (50.19%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R+  L+D+P  +  +QL ++WN  D S+NI VK  D LT HRHPVAQSTD IRGK+G  +G H+W I W  R+RGTHAVVGVCT DAPLH  GY SL+G TE+SWGWD+ R KL H  S +    TYP I+ +D   L            V +   V LDM+EGTLSFI D QYLG+AF GL+G+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+     + R           +L   I QL +P  +K YL
Sbjct:   36 PARIDILLDMPPASRDLQLKHSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSVGYQSLVGSTEQSWGWDLGRNKLYH-DSKNCAGVTYPAILKNDEAFL------------VPDKFLVALDMDEGTLSFIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQ----KIGRT----------NLEEHIQQLQLPLSMKTYL 273
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Fly
Match: gus (gene:FBgn0026238 transcript:FBtr0309847)

HSP 1 Score: 233.417 bits (594), Expect = 2.198e-73
Identity = 133/265 (50.19%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R+  L+D+P  +  +QL ++WN  D S+NI VK  D LT HRHPVAQSTD IRGK+G  +G H+W I W  R+RGTHAVVGVCT DAPLH  GY SL+G TE+SWGWD+ R KL H  S +    TYP I+ +D   L            V +   V LDM+EGTLSFI D QYLG+AF GL+G+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+     + R           +L   I QL +P  +K YL
Sbjct:   36 PARIDILLDMPPASRDLQLKHSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSVGYQSLVGSTEQSWGWDLGRNKLYH-DSKNCAGVTYPAILKNDEAFL------------VPDKFLVALDMDEGTLSFIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQ----KIGRT----------NLEEHIQQLQLPLSMKTYL 273
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Fly
Match: gus (gene:FBgn0026238 transcript:FBtr0309848)

HSP 1 Score: 233.417 bits (594), Expect = 2.198e-73
Identity = 133/265 (50.19%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R+  L+D+P  +  +QL ++WN  D S+NI VK  D LT HRHPVAQSTD IRGK+G  +G H+W I W  R+RGTHAVVGVCT DAPLH  GY SL+G TE+SWGWD+ R KL H  S +    TYP I+ +D   L            V +   V LDM+EGTLSFI D QYLG+AF GL+G+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+     + R           +L   I QL +P  +K YL
Sbjct:   36 PARIDILLDMPPASRDLQLKHSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSVGYQSLVGSTEQSWGWDLGRNKLYH-DSKNCAGVTYPAILKNDEAFL------------VPDKFLVALDMDEGTLSFIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQ----KIGRT----------NLEEHIQQLQLPLSMKTYL 273
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Zebrafish
Match: spsb4a (splA/ryanodine receptor domain and SOCS box containing 4a [Source:ZFIN;Acc:ZDB-GENE-070911-3])

HSP 1 Score: 237.654 bits (605), Expect = 7.451e-75
Identity = 133/268 (49.63%), Postives = 170/268 (63.43%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH--KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL  L+D+P  +Y+ QL +AWN  D S+NI +K  D LT HRHPVAQSTD IRG++G+ RG H+WRI W  R+RGTHAVVGV T DAPLH  GY SL+G   ESWGWD+ R KL H  K        TYP  +             P     + +++ V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LC    R+  R+ + R  LQ           +I+ L +P+ LK YL+
Sbjct:   35 PARLDLLLDMPPASYEQQLRHAWNSDDRSLNIFIKDDDKLTFHRHPVAQSTDGIRGRVGYTRGLHVWRIHWPARQRGTHAVVGVATGDAPLHSVGYTSLVGSDSESWGWDLGRNKLYHNSKNRPASSAPTYPSFL------------EPEEAFVLPDTLMVVLDMDEGTLSFMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMRYINGLDPEPLPLMDLC----RRAARLALGRERLQ-----------EIETLPLPQSLKNYLQ 275
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Zebrafish
Match: spsb4a (splA/ryanodine receptor domain and SOCS box containing 4a [Source:ZFIN;Acc:ZDB-GENE-070911-3])

HSP 1 Score: 237.654 bits (605), Expect = 7.451e-75
Identity = 133/268 (49.63%), Postives = 170/268 (63.43%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH--KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL  L+D+P  +Y+ QL +AWN  D S+NI +K  D LT HRHPVAQSTD IRG++G+ RG H+WRI W  R+RGTHAVVGV T DAPLH  GY SL+G   ESWGWD+ R KL H  K        TYP  +             P     + +++ V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LC    R+  R+ + R  LQ           +I+ L +P+ LK YL+
Sbjct:   35 PARLDLLLDMPPASYEQQLRHAWNSDDRSLNIFIKDDDKLTFHRHPVAQSTDGIRGRVGYTRGLHVWRIHWPARQRGTHAVVGVATGDAPLHSVGYTSLVGSDSESWGWDLGRNKLYHNSKNRPASSAPTYPSFL------------EPEEAFVLPDTLMVVLDMDEGTLSFMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMRYINGLDPEPLPLMDLC----RRAARLALGRERLQ-----------EIETLPLPQSLKNYLQ 275
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Zebrafish
Match: spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6122])

HSP 1 Score: 224.172 bits (570), Expect = 9.782e-70
Identity = 125/265 (47.17%), Postives = 166/265 (62.64%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P RL  L+D+P  +  +Q+ ++WN  D S+NI VK  + L  HRHPVAQSTD+IRG++G+ RG H+W I W +R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R KL H    +   +TYP  +             P+    V +S  V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCE+ + ++  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   34 PSRLDMLLDMPSASQDIQVQHSWNNDDRSLNIFVKEDNKLIFHRHPVAQSTDAIRGRVGYTRGLHVWEISWAMRQRGTHAVVGVATGEAPLHSVGYTALVGNNSESWGWDLGRNKLYHDGK-NQPSRTYPAFL------------EPDETFIVPDSFLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEIRIRYINGLDPEPLPLMDLC----RRSVRVALGRERLS-----------EIHGLPLPASLKNYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Zebrafish
Match: spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6122])

HSP 1 Score: 224.172 bits (570), Expect = 9.782e-70
Identity = 125/265 (47.17%), Postives = 166/265 (62.64%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P RL  L+D+P  +  +Q+ ++WN  D S+NI VK  + L  HRHPVAQSTD+IRG++G+ RG H+W I W +R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R KL H    +   +TYP  +             P+    V +S  V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCE+ + ++  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   34 PSRLDMLLDMPSASQDIQVQHSWNNDDRSLNIFVKEDNKLIFHRHPVAQSTDAIRGRVGYTRGLHVWEISWAMRQRGTHAVVGVATGEAPLHSVGYTALVGNNSESWGWDLGRNKLYHDGK-NQPSRTYPAFL------------EPDETFIVPDSFLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEIRIRYINGLDPEPLPLMDLC----RRSVRVALGRERLS-----------EIHGLPLPASLKNYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Zebrafish
Match: spsb4b (splA/ryanodine receptor domain and SOCS box containing 4b [Source:ZFIN;Acc:ZDB-GENE-040801-213])

HSP 1 Score: 214.157 bits (544), Expect = 1.003e-65
Identity = 126/267 (47.19%), Postives = 158/267 (59.18%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH-KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL  L+D+P    + QL +AWNP D S N+ +K  D LT HRHPVAQSTD +RGK GF RG H W + W +R+RGTHAVVGV T  A L   GY +L+G   ESWGWD+ R +L H ++S       YP  + D         E       V E I V+LDM+EGTL F  DG YLGVAF GLKG+ LYP +SAVWGHCEV+M ++  L+P PLPL+ LCR   R+ L     R+ +             I  L +P+ LK YL+
Sbjct:   37 PARLELLLDMPPAGSEAQLQHAWNPDDRSPNLFIKDDDRLTFHRHPVAQSTDCVRGKTGFTRGLHAWSLRWPVRQRGTHAVVGVATSLATLRAVGYSALVGSDAESWGWDLGRGRLYHDRKSRSGPAPPYPEFVED---------EDEEGTFSVPEEILVVLDMDEGTLGFCADGNYLGVAFRGLKGKRLYPIVSAVWGHCEVSMNYINGLDPEPLPLMELCRRAARQAL----GRHRIH-----------HIQSLPLPQTLKNYLQ 279
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Xenopus
Match: veph1 (ventricular zone expressed PH domain containing 1 [Source:Xenbase;Acc:XB-GENE-6041921])

HSP 1 Score: 236.113 bits (601), Expect = 4.116e-74
Identity = 133/266 (50.00%), Postives = 172/266 (64.66%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL  L+D+P  + ++Q  +AWN  D S+NI VK  D LT HRHPVAQSTD IRGK+G+ RG H+W+I W  R+RGTHAVVGV T DAPLH  GY SL+G   ESWGWD+ R KL +  S +    TYP  +             P+ +  + +S+ V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LC    R+ +R  V R+ L            +I+ L +P+ LK YL+
Sbjct:   34 PARLDMLLDMPTVSLEVQQKHAWNNEDRSLNIFVKEEDRLTFHRHPVAQSTDCIRGKVGYTRGLHVWQIHWPTRQRGTHAVVGVSTADAPLHSVGYTSLVGSNSESWGWDLGRNKL-YNNSKNQPGVTYPAFL------------EPDESFVLPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMRYINGLDPEPLPLMDLC----RRSVRFAVGRDRLH-----------QIESLPLPQALKNYLQ 271
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Xenopus
Match: SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:NCBI gene;Acc:100380153])

HSP 1 Score: 227.639 bits (579), Expect = 7.100e-71
Identity = 129/269 (47.96%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  470 DKC-PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  ++++QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGKIG+ RG H+W I W +R+RGTHAVVGV T DAPLH  GY +LIG   +SWGWD+ R KL H    +   +TYP  +             P+    V +S  V+LDM++GTLSF+ DGQY+G+AF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LCR  +R                A+  D   +I  L +P  LK YL
Sbjct:   30 DYCKPARLDLLLDMPPVSHEVQLQHSWNNNDRSLNVFVKEDDKLVFHRHPVAQSTDAIRGKIGYTRGLHVWEITWVMRQRGTHAVVGVATADAPLHSVGYTTLIGSNGKSWGWDLGRNKLYHDGK-NQPSRTYPAFL------------EPDETFIVPDSFLVVLDMDDGTLSFVVDGQYMGIAFRGLKGKKLYPVVSAVWGHCEIKMRYLNGLDPEPLPLMDLCRRSVRL---------------ALGKDRLNEIQALPLPAALKGYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Xenopus
Match: fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) [Source:Xenbase;Acc:XB-GENE-480496])

HSP 1 Score: 139.428 bits (350), Expect = 2.870e-37
Identity = 77/199 (38.69%), Postives = 117/199 (58.79%), Query Frame = 2 
Query:  497 LMDIPHFTYKMQ-LAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTM 1090
            L ++P +  KM+   + ++  D S N+ +K  +  TLHR+P+AQSTD  R KIGF+ G H W + W+    GT AV+G+ TK AP+ C GY +L+G  ++SWGW+++   L+H   V+    ++P                     ++ E I V+LDME+ TL+F    ++LGVAF GL    LYPA+SAV+G+ EVT+
Sbjct:   93 LCNLPTYKAKMRAFQHGFSSSDCSRNVYIK-KNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWE-GPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVN---GSFPQC-------------NNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKTCLYPAVSAVYGNTEVTL 273
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Xenopus
Match: fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) [Source:Xenbase;Acc:XB-GENE-480496])

HSP 1 Score: 99.3673 bits (246), Expect = 4.323e-23
Identity = 48/118 (40.68%), Postives = 75/118 (63.56%), Query Frame = 2 
Query:  497 LMDIPHFTYKMQ-LAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVD 847
            L ++P +  KM+   + ++  D S N+ +K  +  TLHR+P+AQSTD  R KIGF+ G H W + W+    GT AV+G+ TK AP+ C GY +L+G  ++SWGW+++   L+H   V+
Sbjct:   93 LCNLPTYKAKMRAFQHGFSSSDCSRNVYIK-KNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWE-GPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVN 208
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Mouse
Match: Spsb4 (splA/ryanodine receptor domain and SOCS box containing 4 [Source:MGI Symbol;Acc:MGI:2183445])

HSP 1 Score: 233.417 bits (594), Expect = 2.554e-73
Identity = 132/266 (49.62%), Postives = 163/266 (61.28%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL QL+D+P     +QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRGK+G  RG H W+I W  R+RGTHAVVGV T  APLH  GY +L+G   ESWGWD+ R +L H    +     YP  +             P+    + +S+ V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCEVTM ++  L+P PLPL+ LCR  IR  L     R+               I  L +P+ LK YL+
Sbjct:   34 PARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIHWPARQRGTHAVVGVATARAPLHSVGYTALVGSDSESWGWDLGRSRLYH-DGKNRPGVAYPAFLG------------PDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLRD---------------IGSLPLPQSLKNYLQ 271
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Mouse
Match: Spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:MGI Symbol;Acc:MGI:1921896])

HSP 1 Score: 227.639 bits (579), Expect = 5.435e-71
Identity = 129/269 (47.96%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  470 DKCPP-RLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + +  L             I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGKERLG-----------AIPALPLPASLKAYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Mouse
Match: Spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:MGI Symbol;Acc:MGI:1921896])

HSP 1 Score: 227.639 bits (579), Expect = 5.435e-71
Identity = 129/269 (47.96%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  470 DKCPP-RLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + +  L             I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGKERLG-----------AIPALPLPASLKAYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Mouse
Match: Spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:MGI Symbol;Acc:MGI:1921896])

HSP 1 Score: 227.639 bits (579), Expect = 5.435e-71
Identity = 129/269 (47.96%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  470 DKCPP-RLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + +  L             I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGKERLG-----------AIPALPLPASLKAYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Mouse
Match: Spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:MGI Symbol;Acc:MGI:1921896])

HSP 1 Score: 189.119 bits (479), Expect = 3.690e-57
Identity = 94/185 (50.81%), Postives = 121/185 (65.41%), Query Frame = 2 
Query:  470 DKC-PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAF 1021
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAF 201
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BLAST of SPRY domain containing SOCS box protein-1 vs. UniProt/SwissProt
Match: sp|Q96A44|SPSB4_HUMAN (SPRY domain-containing SOCS box protein 4 OS=Homo sapiens OX=9606 GN=SPSB4 PE=1 SV=1)

HSP 1 Score: 237.269 bits (604), Expect = 6.210e-74
Identity = 136/269 (50.56%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQ---TYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL QL+D+P     +QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRGK+G  RG H W+I+W  R+RGTHAVVGV T  APLH  GY +L+G   ESWGWD+ R +L H    D ++Q    YP  +             P+    + +S+ V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCEVTM ++  L+P PLPL+ LCR  IR  L     R  LQ            I  L +P+ LK YL+
Sbjct:   34 PARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYH----DGKNQPGVAYPAFLG------------PDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSAL----GRQRLQ-----------DISSLPLPQSLKNYLQ 271
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BLAST of SPRY domain containing SOCS box protein-1 vs. UniProt/SwissProt
Match: sp|Q8R5B6|SPSB4_MOUSE (SPRY domain-containing SOCS box protein 4 OS=Mus musculus OX=10090 GN=Spsb4 PE=1 SV=1)

HSP 1 Score: 233.417 bits (594), Expect = 1.786e-72
Identity = 132/266 (49.62%), Postives = 163/266 (61.28%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL QL+D+P     +QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRGK+G  RG H W+I W  R+RGTHAVVGV T  APLH  GY +L+G   ESWGWD+ R +L H    +     YP  +             P+    + +S+ V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCEVTM ++  L+P PLPL+ LCR  IR  L     R+               I  L +P+ LK YL+
Sbjct:   34 PARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIHWPARQRGTHAVVGVATARAPLHSVGYTALVGSDSESWGWDLGRSRLYH-DGKNRPGVAYPAFLG------------PDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLRD---------------IGSLPLPQSLKNYLQ 271
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BLAST of SPRY domain containing SOCS box protein-1 vs. UniProt/SwissProt
Match: sp|A1Z6E0|GUS_DROME (Protein gustavus OS=Drosophila melanogaster OX=7227 GN=gus PE=1 SV=2)

HSP 1 Score: 233.417 bits (594), Expect = 2.204e-72
Identity = 133/265 (50.19%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P R+  L+D+P  +  +QL ++WN  D S+NI VK  D LT HRHPVAQSTD IRGK+G  +G H+W I W  R+RGTHAVVGVCT DAPLH  GY SL+G TE+SWGWD+ R KL H  S +    TYP I+ +D   L            V +   V LDM+EGTLSFI D QYLG+AF GL+G+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+     + R           +L   I QL +P  +K YL
Sbjct:   36 PARIDILLDMPPASRDLQLKHSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSVGYQSLVGSTEQSWGWDLGRNKLYH-DSKNCAGVTYPAILKNDEAFL------------VPDKFLVALDMDEGTLSFIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQ----KIGRT----------NLEEHIQQLQLPLSMKTYL 273
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BLAST of SPRY domain containing SOCS box protein-1 vs. UniProt/SwissProt
Match: sp|Q96BD6|SPSB1_HUMAN (SPRY domain-containing SOCS box protein 1 OS=Homo sapiens OX=9606 GN=SPSB1 PE=1 SV=1)

HSP 1 Score: 229.18 bits (583), Expect = 1.029e-70
Identity = 130/269 (48.33%), Postives = 169/269 (62.83%), Query Frame = 2 
Query:  470 DKC-PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGRERLG-----------EIHTLPLPASLKAYL 270
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BLAST of SPRY domain containing SOCS box protein-1 vs. UniProt/SwissProt
Match: sp|Q9D5L7|SPSB1_MOUSE (SPRY domain-containing SOCS box protein 1 OS=Mus musculus OX=10090 GN=Spsb1 PE=1 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 3.802e-70
Identity = 129/269 (47.96%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  470 DKCPP-RLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            D C P RL  L+D+P  +Y +QL ++WN  D S+N+ VK  D L  HRHPVAQSTD+IRGK+G+ RG H+W+I W +R+RGTHAVVGV T DAPLH  GY +L+G   ESWGWD+ R +L H    +   +TYP  +             P+    V +S  V LDM++GTLSFI DGQY+GVAF GLKG+ LYP +SAVWGHCE+ M +L  L+P PLPL+ LC    R+ +R+ + +  L             I  L +P  LK YL
Sbjct:   30 DYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGK-NQPSKTYPAFL------------EPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLC----RRSVRLALGKERLG-----------AIPALPLPASLKAYL 270
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BLAST of SPRY domain containing SOCS box protein-1 vs. TrEMBL
Match: I1ZI79 (SPRY domain containing SOCS box protein-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0
Identity = 310/311 (99.68%), Postives = 311/311 (100.00%), Query Frame = 2 
Query:  356 MPEHDECEFCMSSKRMRTSYRXXXXXXXXLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSF 1288
            MPEHDECEFCMSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIA+DICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLASLNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSF
Sbjct:    1 MPEHDECEFCMSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIAEDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLASLNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSF 311
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BLAST of SPRY domain containing SOCS box protein-1 vs. TrEMBL
Match: E9GL80 (Uncharacterized protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_304377 PE=4 SV=1)

HSP 1 Score: 245.743 bits (626), Expect = 1.398e-74
Identity = 132/265 (49.81%), Postives = 172/265 (64.91%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P RL  L+D+P  + +++L +AWN  D S+NI VK  DPLT HRHPVAQSTD IRG++GF RG H+W ++W  R+RGTHAVVGV T  APLH  GY SL+G  ++SWGWD+ R KL H  S +    TYP I+  D             N  V +S +V+LDM+EGTL+F+ DGQYLGVAF GLKG+ LYP +SAVWGHCE+TM ++  L+P PL L  LCR  +R+     V +  L+           ++D+LN+P  LK YL
Sbjct:   43 PSRLEALLDMPPTSREVELKHAWNADDRSLNIFVKEEDPLTFHRHPVAQSTDCIRGRVGFTRGLHVWELNWSTRQRGTHAVVGVATLTAPLHSVGYQSLVGSNDQSWGWDLGRNKLYH-DSKNQAGTTYPAILKSD------------ENFTVPDSFYVVLDMDEGTLAFVVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMKYIGGLDPEPLTLTDLCRRVVRQ----TVGKQRLE-----------RLDELNLPPALKSYL 279
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. TrEMBL
Match: A0A1Y1KHX1 (Uncharacterized protein OS=Photinus pyralis OX=7054 PE=4 SV=1)

HSP 1 Score: 239.58 bits (610), Expect = 2.492e-72
Identity = 134/265 (50.57%), Postives = 168/265 (63.40%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P RL  L+D+P    + QL Y+WN  D S+NI VK  D LT HRHPVAQSTD IRGKIGF +G H W + W  R+RGTHAVVGV T +APLH  GY SL+G T+ SWGWD+ R KL H  S +    TYP ++            +P+    V +   V+LDM+EGTLSF+ DGQYLGVAF GLKGR LYP +SAVWGHCE+TM ++  L+P PLPL  LCR  IR+  RI  A            ++  ++  LN+P+ L+ YL
Sbjct:   34 PARLDMLLDMPPALRETQLKYSWNADDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKIGFTKGLHAWEVSWSTRQRGTHAVVGVATSEAPLHSVGYQSLVGSTDSSWGWDLGRNKLYH-DSKNYAGVTYPALL------------KPDETFIVPDKFVVVLDMDEGTLSFMVDGQYLGVAFRGLKGRKLYPIVSAVWGHCEITMKYIGGLDPEPLPLTDLCRRIIRQ--RIGKA------------NIEERVSSLNLPQPLQTYL 271
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. TrEMBL
Match: G1QX22 (SplA/ryanodine receptor domain and SOCS box containing 4 OS=Nomascus leucogenys OX=61853 GN=SPSB4 PE=4 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 4.607e-72
Identity = 136/269 (50.56%), Postives = 168/269 (62.45%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQ---TYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL QL+D+P     +QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRGK+G  RG H W+IDW  R+RGTHAVVGV T  APLH  GY +L+G   ESWGWD+ R +L H    D ++Q    YP  +             P+    + +S+ V+LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCEVTM ++  L+P PLPL+ LCR  +R  L     R  LQ            I  L +P+ LK YL+
Sbjct:   34 PARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIDWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYH----DGKNQPGVAYPAFLG------------PDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSVRSAL----GRQRLQ-----------DISSLPLPQSLKNYLQ 271
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. TrEMBL
Match: A0A1B0DDB7 (Uncharacterized protein OS=Phlebotomus papatasi OX=29031 PE=4 SV=1)

HSP 1 Score: 239.195 bits (609), Expect = 5.053e-72
Identity = 132/265 (49.81%), Postives = 168/265 (63.40%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P RL  L+D+P    + Q+ Y+WN  D S+NI VK  D LT HRHPVAQSTD IRGK+GF +G H+W + W  R+RGTHAVVGV T +APLH  GY SL+G T++SWGWD+ R KL H  S +    TYP I+            +P+    V +   V LDM+EGTLSFI DGQYLGVAF GLKG+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LCR  IR+ +                + L  +I +L +PE +K YL
Sbjct:   37 PARLDVLLDMPAAARETQVKYSWNSEDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKVGFTKGLHVWEVFWSTRQRGTHAVVGVATAEAPLHSVGYQSLVGSTDQSWGWDLGRNKLYH-DSKNCAGVTYPAIL------------KPDEAFLVPDKFLVALDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMKYIGGLDPEPLPLMDLCRRVIRQKIG--------------RHRLEERIQELQLPESMKTYL 274
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Cavefish
Match: spsb4a (SPRY domain-containing SOCS box protein 4-like [Source:NCBI gene;Acc:103021520])

HSP 1 Score: 235.343 bits (599), Expect = 5.699e-74
Identity = 132/268 (49.25%), Postives = 171/268 (63.81%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH--KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            P RL  L+D+P   Y++QL +AWN  D S+NI +K  D LT HRHPVAQSTD IRG++G+ RG H+WRI W  R+RGTHAVVGV T +APLH  GY SL+G   ESWGWD+ R KL H  K        TYP  +             P     + +++ V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCE+TM ++  L+P PLPL+ LC    R+  R+ + R+ LQ           +I+ L +P+ LK YL+
Sbjct:   35 PARLDLLLDMPPAPYELQLRHAWNADDRSLNIFIKDDDKLTFHRHPVAQSTDCIRGRVGYTRGLHVWRIHWPSRQRGTHAVVGVATAEAPLHSVGYTSLVGSDGESWGWDLGRNKLYHNSKNRPASSSPTYPSFL------------EPEEAFVLPDTLVVVLDMDEGTLSFMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMRYINGLDPEPLPLMDLC----RRAARLALGRDRLQ-----------QIETLPLPQSLKNYLQ 275
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Cavefish
Match: spsb1 (splA/ryanodine receptor domain and SOCS box containing 1 [Source:NCBI gene;Acc:103042472])

HSP 1 Score: 225.328 bits (573), Expect = 3.409e-70
Identity = 127/265 (47.92%), Postives = 167/265 (63.02%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            P RL  L+D+P  T ++Q+ ++WN  D S+NI VK  + L  HRHPVAQSTD+IRG++G+ RG H+W I W +R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R KL H    +   +TYP  +             P+    V +S  V+LDM+EGTLSFI DGQYLGVAF GLKGR LYP +SAVWGHCE+ + ++  L+P PLPL+ LC    R+ +R+ + R  L            +I  L +P  LK YL
Sbjct:   34 PSRLDMLLDMPPATGEVQVQHSWNNDDRSLNIFVKEDNKLIFHRHPVAQSTDAIRGRVGYTRGLHVWEISWAMRQRGTHAVVGVATGEAPLHSVGYTALVGNNNESWGWDLGRNKLYHDGK-NQPSRTYPAFL------------EPDETFIVPDSFLVVLDMDEGTLSFIVDGQYLGVAFRGLKGRKLYPVVSAVWGHCEIRIRYINGLDPEPLPLMDLC----RRSVRVALGRERLS-----------EIHGLPLPVSLKNYL 270
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Cavefish
Match: spsb4b (splA/ryanodine receptor domain and SOCS box containing 4b [Source:ZFIN;Acc:ZDB-GENE-040801-213])

HSP 1 Score: 209.149 bits (531), Expect = 5.940e-64
Identity = 121/259 (46.72%), Postives = 157/259 (60.62%), Query Frame = 2 
Query:  503 DIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH-KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            D+P      QL +AWNP D S+N+ +K  D LT HRHPVAQSTD  RG++G+ RG H W I W +R+RGTHAV+GV T  APLH  GY +L+G   ESWGWD+ R KL H ++S   +  +YP+   DD                V E + V+LDM+EGTL F  DG++LG+AF GLKG  LYP +SAVWGHCEVTM ++  L+P PLPL+ LCR   R+ L     R+ +             I  L +P+ LK YL+
Sbjct:   44 DMPPVGVASQLQHAWNPNDRSLNLFIKDEDKLTFHRHPVAQSTDCARGRVGYVRGLHAWTIRWPIRQRGTHAVIGVATSLAPLHAVGYTALVGSDAESWGWDLGRGKLYHDRKSQTGQPPSYPLPEEDD---------DDEGVFSVPEEVLVVLDMDEGTLGFCADGRFLGMAFRGLKGMKLYPIVSAVWGHCEVTMTYVNGLDPEPLPLMELCRRAARQAL----GRHRIH-----------HIQSLPLPQTLKNYLQ 278
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Cavefish
Match: fbxo45 (F-box protein 45 [Source:NCBI gene;Acc:103025525])

HSP 1 Score: 138.658 bits (348), Expect = 2.968e-37
Identity = 81/195 (41.54%), Postives = 115/195 (58.97%), Query Frame = 2 
Query:  518 TYKMQLA---YAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNT-NIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTM 1090
            TYK +L    +A +  D S N+ VK  +  TLHR+P+AQSTD  RGKIGF  G H W I W+    GT AV+G+ TK AP+ C GY +L+G  ++SWGW+++   L+H   V+                 G+  +  N    ++ E I V+LDM++ TL+F    ++LGVAF GL    L+PA+SAV+G+ EVTM
Sbjct:   98 TYKGKLKSFQHALSSHDCSRNVYVK-KNGFTLHRNPIAQSTDGARGKIGFTEGRHAWEIWWE-GPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVN-----------------GNFPQCNNAPKYQIGERIRVILDMDDKTLAFERGFEFLGVAFRGLPKTCLFPAVSAVYGNTEVTM 273
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Sea Lamprey
Match: si:ch1073-228j22.2 (si:ch1073-228j22.2 [Source:ZFIN;Acc:ZDB-GENE-110411-227])

HSP 1 Score: 193.356 bits (490), Expect = 1.099e-58
Identity = 110/265 (41.51%), Postives = 152/265 (57.36%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYL 1273
            PP+L  L+  P     +Q+ + ++  D S ++ +K  D LT+HR P+  +TD+ RG+  + RG H W I W   +RGTHA VGV T DAPL   GY +L+G   ESWGWD+ R K  H  +VD   + YP  +             P  +  V E + + LDMEEGTLSF+ DG+YLGVAFSGL+G+TLYPA+SAVWG+CE+ M ++  + P PLPL  LCR  IR               + +  D   +I+ L +P  +K YL
Sbjct:   33 PPQLAFLLSQPAAPRGLQVQHGFSSTDLSPSMSLKEGDALTVHRRPMRDTTDAARGRTAYRRGVHTWEITWPTEQRGTHAAVGVATSDAPLEATGYVALVGRGRESWGWDLGRCKAYHG-AVDSPGRPYPAHLL------------PCESFHVPERLVMALDMEEGTLSFVVDGEYLGVAFSGLRGKTLYPAVSAVWGNCEIKMRYINGIEPGPLPLDELCRRSIR---------------NCLGNDRLEEINALPLPTLIKRYL 269
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001173.1 (pep scaffold:Pmarinus_7.0:GL481490:14086:14830:1 gene:ENSPMAG00000001050.1 transcript:ENSPMAT00000001173.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 172.17 bits (435), Expect = 3.169e-51
Identity = 82/151 (54.30%), Postives = 98/151 (64.90%), Query Frame = 2 
Query:  647 KIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSV---DVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTM 1090
             +GF RG H W + W  R+RGTHAVVGV T DAPLH  GY SL+G T +SWGWD+ R KL H       D E +TYP  +  D             +  V +S  V+LDM+EGT+SF+ DGQYLGVAF GLKGR LYP +SAVWGHCE+TM
Sbjct:   67 SVGFTRGLHAWEVTWPARQRGTHAVVGVATADAPLHSVGYTSLVGSTADSWGWDLGRNKLYHAGKAVGRDGEHRTYPAYLTAD------------ESFVVSDSFLVVLDMDEGTVSFVVDGQYLGVAFRGLKGRKLYPVVSAVWGHCEITM 205
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Nematostella
Match: EDO41486 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4A9])

HSP 1 Score: 229.18 bits (583), Expect = 5.266e-72
Identity = 124/230 (53.91%), Postives = 153/230 (66.52%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFIN-DGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHL 1165
            P +L  ++D P    + Q  +AWNP D S+N+ VK  DP T HRHPVAQSTDSIR K+GFNRGFH+W I W  R+RGTHAVVGV T  APLHC GY SL+G TE+ WGWDI+R KL H +  +     YP   AD        IE    N  V +   V+LDM+EGTL+F   +G+YLGVAF GLKG+T+YP +SAVWGHCE+ M ++  L+P P PL  LCR  IRK +
Sbjct:   40 PEKLDIVLDRPALPEERQAEFAWNPADRSVNVFVKDDDPFTFHRHPVAQSTDSIRAKVGFNRGFHVWEIHWSTRQRGTHAVVGVATAKAPLHCTGYHSLVGNTEDGWGWDIVRNKLYHDEKGN-STVKYPAHNAD--------IEH---NFVVPDRFRVILDMDEGTLAFETLEGKYLGVAFRGLKGQTVYPVVSAVWGHCEIAMRYIGGLDPEPQPLQDLCRRAIRKSI 257
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Nematostella
Match: EDO48444 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJX3])

HSP 1 Score: 75.485 bits (184), Expect = 2.452e-15
Identity = 68/215 (31.63%), Postives = 102/215 (47.44%), Query Frame = 2 
Query:  470 DKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLT-LHRHPVAQSTDS--IRGKIGFNRGFHMWRIDWKLRE-RGTHAVVGVCTKDAPLHC--HGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGR--TLYPAISAVWGHCEVTM 1090
            + C  +L+    +P +T      + W+    S N+ +   + +   H  PV +ST +  + G   F  G H W I  KL + RGT  ++GV T+DA LH   + Y +L+G  +ESWG       L H+  +    Q +                 P  +  V   I VLLDM++GT+SF  +GQ LGVAF+GL+ R   LYP  S+     EV +
Sbjct:   26 NSCTRKLM----VPPWTSFFVEEWVWDFQSRSPNVYLCYHNKVACFHIDPVVESTGTAAVLGNKAFAHGQHYWEI--KLTDVRGTSMMIGVATQDAMLHTDNYEYVNLVGRDQESWG-------LSHRGEIWHGGQKWKFC-------------EPFFDSTV---IGVLLDMDKGTISFFKNGQPLGVAFTGLQDRGCELYPIASSTASESEVEL 211
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Nematostella
Match: EDO28769 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T5J3])

HSP 1 Score: 71.2478 bits (173), Expect = 7.753e-15
Identity = 57/162 (35.19%), Postives = 80/162 (49.38%), Query Frame = 2 
Query:  620 AQSTDSIRGKIGFNRGFHMWRIDWKLRE-RGTHAVVGVCTKDAPLHC--HGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRT--LYPAISAVWGHCEVTM 1090
            +  T ++ G   F  G H W I  KL + RGT  ++GV T+DA LH   + Y +L+G  +ESWG       L H+  +    Q +                 P  +  V   I VLLDM++GT+SF  +GQ LGVAF+GL+ R   LYP  S+     EV +
Sbjct:    1 STGTAAVLGNKAFAHGQHYWEI--KLTDVRGTSMMIGVATQDAMLHTDNYEYVNLVGRDQESWG-------LSHRGEIWHGGQKWKFC-------------EPFFDSTV---IGVLLDMDKGTISFFKNGQPLGVAFTGLQDRGCELYPIASSTASESEVEL 137
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Nematostella
Match: EDO48347 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJX4])

HSP 1 Score: 58.151 bits (139), Expect = 5.497e-10
Identity = 42/139 (30.22%), Postives = 61/139 (43.88%), Query Frame = 2 
Query:  656 FNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCH--GYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAV 1066
            F+ G H W +       GT  +VGV TKD  L  +   +CS++G  ++SWG         H   +   D T                    T  +   +I + +D   G L+F+ D Q LGVA  GLKG+ LYP +S+ 
Sbjct:   16 FDGGVHYWEVKMTSAVYGTDMMVGVGTKDTDLERYRSSFCSILGRDQDSWGLSYF--GTFHHDGL-THDYT--------------------TKFDRGTTIGIHVDTWSGRLTFLRDDQPLGVAAEGLKGKELYPMVSST 131
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Medaka
Match: spsb4a (SPRY domain-containing SOCS box protein 4 [Source:NCBI gene;Acc:101156850])

HSP 1 Score: 232.646 bits (592), Expect = 7.858e-73
Identity = 129/268 (48.13%), Postives = 171/268 (63.81%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH--KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            PPRL  L+D+P    + QL +AWNP D S+NI +K  D LT HRHPVAQSTD IRG++G+ RG H+W I W  R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R +L H  K        +YP  +             P     + +S+ V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCE++M ++  L+P PLPL+ LC    R+  R+ + R+ LQ           +I++L +P+ LK YL+
Sbjct:   44 PPRLDLLLDMPCVGVETQLRHAWNPDDRSLNIFIKDDDKLTFHRHPVAQSTDCIRGRVGYTRGLHVWNIHWPARQRGTHAVVGVATAEAPLHSVGYTALVGSDSESWGWDLGRNRLYHDSKNRAHSSLPSYPCFL------------EPEETFILPDSLLVILDMDEGTLSFMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEISMRYINGLDPEPLPLMDLC----RRAARLALGRDRLQ-----------EIERLPLPQSLKNYLQ 284
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Medaka
Match: spsb4a (SPRY domain-containing SOCS box protein 4 [Source:NCBI gene;Acc:101166894])

HSP 1 Score: 229.18 bits (583), Expect = 1.026e-71
Identity = 129/269 (47.96%), Postives = 172/269 (63.94%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH---KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            PPRL  L+D+P  + + QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRG++G+ RG H+WRI W +R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R +L H    + V     TYP  +             P+ +  + + + V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCEV++ ++  L+P PLPL+ LC    R+  R+ + R  +             ID L +P+ LK YL+
Sbjct:   35 PPRLDLLLDMPPASAETQLRHAWNPDDRSLNVFVKEDDKLTFHRHPVAQSTDCIRGRVGYTRGLHVWRIHWPVRQRGTHAVVGVATAEAPLHSVGYTALVGSDSESWGWDLGRNRLNHDGKNRPVSSCAPTYPSFL------------EPDESFVLPDCLTVILDMDEGTLSFMVDGQYLGVAFRGLKGKRLYPIVSAVWGHCEVSIRYVNGLDPEPLPLMDLC----RRVARLALGRERIH-----------HIDALPLPQTLKNYLQ 276
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Medaka
Match: spsb4a (SPRY domain-containing SOCS box protein 4 [Source:NCBI gene;Acc:101166894])

HSP 1 Score: 229.18 bits (583), Expect = 1.026e-71
Identity = 129/269 (47.96%), Postives = 172/269 (63.94%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH---KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLK 1276
            PPRL  L+D+P  + + QL +AWNP D S+N+ VK  D LT HRHPVAQSTD IRG++G+ RG H+WRI W +R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R +L H    + V     TYP  +             P+ +  + + + V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCEV++ ++  L+P PLPL+ LC    R+  R+ + R  +             ID L +P+ LK YL+
Sbjct:   35 PPRLDLLLDMPPASAETQLRHAWNPDDRSLNVFVKEDDKLTFHRHPVAQSTDCIRGRVGYTRGLHVWRIHWPVRQRGTHAVVGVATAEAPLHSVGYTALVGSDSESWGWDLGRNRLNHDGKNRPVSSCAPTYPSFL------------EPDESFVLPDCLTVILDMDEGTLSFMVDGQYLGVAFRGLKGKRLYPIVSAVWGHCEVSIRYVNGLDPEPLPLMDLC----RRVARLALGRERIH-----------HIDALPLPQTLKNYLQ 276
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Medaka
Match: spsb4a (SPRY domain-containing SOCS box protein 4 [Source:NCBI gene;Acc:101156850])

HSP 1 Score: 224.942 bits (572), Expect = 3.986e-70
Identity = 109/206 (52.91%), Postives = 137/206 (66.50%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH--KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTM 1090
            PPRL  L+D+P    + QL +AWNP D S+NI +K  D LT HRHPVAQSTD IRG++G+ RG H+W I W  R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R +L H  K        +YP  +             P     + +S+ V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCE++M
Sbjct:   44 PPRLDLLLDMPCVGVETQLRHAWNPDDRSLNIFIKDDDKLTFHRHPVAQSTDCIRGRVGYTRGLHVWNIHWPARQRGTHAVVGVATAEAPLHSVGYTALVGSDSESWGWDLGRNRLYHDSKNRAHSSLPSYPCFL------------EPEETFILPDSLLVILDMDEGTLSFMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEISM 237
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Medaka
Match: spsb4a (SPRY domain-containing SOCS box protein 4 [Source:NCBI gene;Acc:101156850])

HSP 1 Score: 225.328 bits (573), Expect = 6.432e-70
Identity = 109/206 (52.91%), Postives = 137/206 (66.50%), Query Frame = 2 
Query:  479 PPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVH--KQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTM 1090
            PPRL  L+D+P    + QL +AWNP D S+NI +K  D LT HRHPVAQSTD IRG++G+ RG H+W I W  R+RGTHAVVGV T +APLH  GY +L+G   ESWGWD+ R +L H  K        +YP  +             P     + +S+ V+LDM+EGTLSF+ DGQYLGVAF GLKG+ LYP +SAVWGHCE++M
Sbjct:   44 PPRLDLLLDMPCVGVETQLRHAWNPDDRSLNIFIKDDDKLTFHRHPVAQSTDCIRGRVGYTRGLHVWNIHWPARQRGTHAVVGVATAEAPLHSVGYTALVGSDSESWGWDLGRNRLYHDSKNRAHSSLPSYPCFL------------EPEETFILPDSLLVILDMDEGTLSFMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEISM 237
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Planmine SMEST
Match: SMESG000053741.1 (SMESG000053741.1)

HSP 1 Score: 598.201 bits (1541), Expect = 0.000e+0
Identity = 312/313 (99.68%), Postives = 313/313 (100.00%), Query Frame = 2 
Query:  356 MPEHDECEFCMSSKRMRTSYRXXXXXXXXLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSFQR 1294
            MPEHDECEFCMSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIA+DICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLASLNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSFQR
Sbjct:    1 MPEHDECEFCMSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIAEDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLASLNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSFQR 313
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Planmine SMEST
Match: SMESG000053741.1 (SMESG000053741.1)

HSP 1 Score: 574.318 bits (1479), Expect = 0.000e+0
Identity = 302/303 (99.67%), Postives = 303/303 (100.00%), Query Frame = 2 
Query:  386 MSSKRMRTSYRXXXXXXXXLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXXXXXXXXXXXCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSFQR 1294
            MSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIA+DICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLASLNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSFQR
Sbjct:    1 MSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMDIPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIAEDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLASLNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGSFQR 303
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Planmine SMEST
Match: SMESG000018608.1 (SMESG000018608.1)

HSP 1 Score: 112.079 bits (279), Expect = 1.912e-28
Identity = 80/198 (40.40%), Postives = 105/198 (53.03%), Query Frame = 2 
Query:  542 AWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIGFNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCH-GYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFIN--DGQYLGVA---FSGL---------KGRTLYPAISAVWGHCEVTM 1090
            AW+  D S NI VK  D  TLHR PVA+STD IRGKIGF+ G H W I W L   GT AVVG+ T+ A LH   GY SL+G  E SWGW+++   L H               ++ +C         +   +V + + ++LD +E  LSF    D   LG +   FS L          G++LYPA+SAV+GH EV +
Sbjct:   17 AWDGEDCSKNIYVKK-DGFTLHRKPVARSTDGIRGKIGFSSGRHCWEI-WWLGPLGTVAVVGIATRQASLHYQGGYISLLGKDEHSWGWNLVDNVLYHGGK------------SEKLC-------ESHLKYKVGDRLRMILDCDERLLSFEKSIDANGLGESEHNFSKLDFSFANVCSNGKSLYPAVSAVYGHSEVCI 193
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Planmine SMEST
Match: SMESG000078551.1 (SMESG000078551.1)

HSP 1 Score: 106.301 bits (264), Expect = 1.489e-26
Identity = 71/204 (34.80%), Postives = 101/204 (49.51%), Query Frame = 2 
Query:  704 RGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIA-DDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXX----XXXXXXXXXCRFYIRKHLRIN-----VARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGS 1285
            RGTHAV+GV T  A L    Y SL+G   ESWGWD+                 YP I     +C++G   + P       + I+++LDM +G+LSF+   ++LG+  +GL+G+TLYP +SAVWGHCEV + + + +      L    L+  R  +R H R N       RN +  D   +      I   NIP  LK  L+  S
Sbjct:    2 RGTHAVIGVATDKAKLQEDRYVSLVGHDNESWGWDM-----------------YPDIRKLRKMCTMGKTFKVP-------QKIYLILDMYQGSLSFVIGNEFLGICHTGLQGKTLYPTVSAVWGHCEVEIKYFSKITNEPPSLYNMSLYQARRLLRYHCRYNEIIGQQGRNHIVSDINSSSVFQDAITDQNIPNVLKKSLRKNS 181
[Close]
BLAST of SPRY domain containing SOCS box protein-1 vs. Planmine SMEST
Match: SMESG000078551.1 (SMESG000078551.1)

HSP 1 Score: 106.686 bits (265), Expect = 3.263e-26
Identity = 71/204 (34.80%), Postives = 101/204 (49.51%), Query Frame = 2 
Query:  704 RGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGWDIIRKKLVHKQSVDVEDQTYPVIIA-DDICSLGDAIERPNTNIEVQESIFVLLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMXXXXXXX----XXXXXXXXXCRFYIRKHLRIN-----VARNFLQMDDAVNYDLSMKIDQLNIPEYLKMYLKNGS 1285
            RGTHAV+GV T  A L    Y SL+G   ESWGWD+                 YP I     +C++G   + P       + I+++LDM +G+LSF+   ++LG+  +GL+G+TLYP +SAVWGHCEV + + + +      L    L+  R  +R H R N       RN +  D   +      I   NIP  LK  L+  S
Sbjct:   44 RGTHAVIGVATDKAKLQEDRYVSLVGHDNESWGWDM-----------------YPDIRKLRKMCTMGKTFKVP-------QKIYLILDMYQGSLSFVIGNEFLGICHTGLQGKTLYPTVSAVWGHCEVEIKYFSKITNEPPSLYNMSLYQARRLLRYHCRYNEIIGQQGRNHIVSDINSSSVFQDAITDQNIPNVLKKSLRKNS 223
The following BLAST results are available for this feature:
BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SPSB41.293e-7450.56splA/ryanodine receptor domain and SOCS box contai... [more]
SPSB12.142e-7148.33splA/ryanodine receptor domain and SOCS box contai... [more]
SPSB12.142e-7148.33splA/ryanodine receptor domain and SOCS box contai... [more]
SPSB12.142e-7148.33splA/ryanodine receptor domain and SOCS box contai... [more]
SPSB22.753e-5749.75splA/ryanodine receptor domain and SOCS box contai... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
spsb-14.081e-6446.04SPSB (SPry and Socs Box) family [Source:UniProtKB... [more]
spsb-14.081e-6446.04SPSB (SPry and Socs Box) family [Source:UniProtKB... [more]
spsb-14.748e-6446.04SPSB (SPry and Socs Box) family [Source:UniProtKB... [more]
spsb-11.402e-6346.04SPSB (SPry and Socs Box) family [Source:UniProtKB... [more]
spsb-11.734e-6346.04SPSB (SPry and Socs Box) family [Source:UniProtKB... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gus2.198e-7350.19gene:FBgn0026238 transcript:FBtr0309850[more]
gus2.198e-7350.19gene:FBgn0026238 transcript:FBtr0309849[more]
gus2.198e-7350.19gene:FBgn0026238 transcript:FBtr0309852[more]
gus2.198e-7350.19gene:FBgn0026238 transcript:FBtr0309847[more]
gus2.198e-7350.19gene:FBgn0026238 transcript:FBtr0309848[more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
spsb4a7.451e-7549.63splA/ryanodine receptor domain and SOCS box contai... [more]
spsb4a7.451e-7549.63splA/ryanodine receptor domain and SOCS box contai... [more]
spsb19.782e-7047.17splA/ryanodine receptor domain and SOCS box contai... [more]
spsb19.782e-7047.17splA/ryanodine receptor domain and SOCS box contai... [more]
spsb4b1.003e-6547.19splA/ryanodine receptor domain and SOCS box contai... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
veph14.116e-7450.00ventricular zone expressed PH domain containing 1 ... [more]
SPSB17.100e-7147.96splA/ryanodine receptor domain and SOCS box contai... [more]
fgf42.870e-3738.69fibroblast growth factor 4 (heparin secretory tran... [more]
fgf44.323e-2340.68fibroblast growth factor 4 (heparin secretory tran... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Spsb42.554e-7349.62splA/ryanodine receptor domain and SOCS box contai... [more]
Spsb15.435e-7147.96splA/ryanodine receptor domain and SOCS box contai... [more]
Spsb15.435e-7147.96splA/ryanodine receptor domain and SOCS box contai... [more]
Spsb15.435e-7147.96splA/ryanodine receptor domain and SOCS box contai... [more]
Spsb13.690e-5750.81splA/ryanodine receptor domain and SOCS box contai... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q96A44|SPSB4_HUMAN6.210e-7450.56SPRY domain-containing SOCS box protein 4 OS=Homo ... [more]
sp|Q8R5B6|SPSB4_MOUSE1.786e-7249.62SPRY domain-containing SOCS box protein 4 OS=Mus m... [more]
sp|A1Z6E0|GUS_DROME2.204e-7250.19Protein gustavus OS=Drosophila melanogaster OX=722... [more]
sp|Q96BD6|SPSB1_HUMAN1.029e-7048.33SPRY domain-containing SOCS box protein 1 OS=Homo ... [more]
sp|Q9D5L7|SPSB1_MOUSE3.802e-7047.96SPRY domain-containing SOCS box protein 1 OS=Mus m... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZI790.000e+099.68SPRY domain containing SOCS box protein-1 OS=Schmi... [more]
E9GL801.398e-7449.81Uncharacterized protein OS=Daphnia pulex OX=6669 G... [more]
A0A1Y1KHX12.492e-7250.57Uncharacterized protein OS=Photinus pyralis OX=705... [more]
G1QX224.607e-7250.56SplA/ryanodine receptor domain and SOCS box contai... [more]
A0A1B0DDB75.053e-7249.81Uncharacterized protein OS=Phlebotomus papatasi OX... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
spsb4a5.699e-7449.25SPRY domain-containing SOCS box protein 4-like [So... [more]
spsb13.409e-7047.92splA/ryanodine receptor domain and SOCS box contai... [more]
spsb4b5.940e-6446.72splA/ryanodine receptor domain and SOCS box contai... [more]
fbxo452.968e-3741.54F-box protein 45 [Source:NCBI gene;Acc:103025525][more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
si:ch1073-228j22.21.099e-5841.51si:ch1073-228j22.2 [Source:ZFIN;Acc:ZDB-GENE-11041... [more]
ENSPMAT00000001173.13.169e-5154.30pep scaffold:Pmarinus_7.0:GL481490:14086:14830:1 g... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO414865.266e-7253.91Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO484442.452e-1531.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO287697.753e-1535.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483475.497e-1030.22Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
spsb4a7.858e-7348.13SPRY domain-containing SOCS box protein 4 [Source:... [more]
spsb4a1.026e-7147.96SPRY domain-containing SOCS box protein 4 [Source:... [more]
spsb4a1.026e-7147.96SPRY domain-containing SOCS box protein 4 [Source:... [more]
spsb4a3.986e-7052.91SPRY domain-containing SOCS box protein 4 [Source:... [more]
spsb4a6.432e-7052.91SPRY domain-containing SOCS box protein 4 [Source:... [more]
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BLAST of SPRY domain containing SOCS box protein-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000053741.10.000e+099.68SMESG000053741.1[more]
SMESG000053741.10.000e+099.67SMESG000053741.1[more]
SMESG000018608.11.912e-2840.40SMESG000018608.1[more]
SMESG000078551.11.489e-2634.80SMESG000078551.1[more]
SMESG000078551.13.263e-2634.80SMESG000078551.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30025986
GenBankAFJ24733.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025986 ID=SMED30025986|Name=SPRY domain containing SOCS box protein-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1436bp
TAAGATGCTAATTTTTGAAATTGAATTCAGCTTTATCTCAGTTTAAGAAA
TGAATTTTTATTGATCATGCATTACTAAATTTAAAATTTATATATAATTT
ATTCTCGATATTTATTAATTTGAATATATTTTACAATTGTTATAAGTTTT
ATTATTTATAATTATAATTGTAAAATAATATTACAGAAATTTGATTTCCA
AGGCCAATCTGTAGAATTACACAATTGAGCTAATTAAATATCAACAACAA
CCGAAAATTGTGCCAATTAAACGACGTAAAAATCGTCCTAATTCTCACAA
TCGCACATTTAAGTCGATTTGGCACATTTTTTATCGCGTTTTTAAACCAG
CTAAAATGCCCGAACATGACGAGTGTGAATTCTGTATGTCTTCCAAACGA
ATGCGGACTAGTTATCGTAGTAATTCTAATAACAACAACAATTTAGTCAC
TGTTTCTCGGCATTATTATGATAAATGCCCACCTCGATTGTTGCAACTAA
TGGATATACCTCACTTTACATATAAAATGCAATTAGCTTATGCTTGGAAC
CCTTTGGATTCGTCGATTAACATCGATGTAAAACTTATTGATCCATTGAC
TTTGCATCGTCATCCCGTAGCACAGAGCACAGATTCCATTCGTGGAAAGA
TTGGATTTAATCGAGGATTTCATATGTGGCGAATTGATTGGAAATTGCGC
GAGAGAGGTACTCATGCCGTCGTTGGAGTATGCACAAAAGATGCCCCTCT
TCATTGCCACGGATATTGCTCTTTGATTGGATTGACTGAGGAATCTTGGG
GTTGGGATATTATTCGCAAGAAATTAGTTCATAAACAATCAGTCGATGTT
GAAGATCAAACATATCCAGTCATCATCGCCGATGATATCTGCAGCCTTGG
TGATGCTATTGAAAGGCCAAACACGAATATCGAGGTGCAAGAATCGATTT
TTGTTCTTCTTGATATGGAAGAGGGGACTTTATCATTTATTAACGATGGT
CAATATTTAGGAGTGGCATTTAGTGGATTAAAGGGTCGCACGCTTTATCC
GGCAATCAGTGCCGTTTGGGGTCACTGTGAGGTCACGATGGCCCATTTAG
CGTCATTGAATCCTCTTCCTCTGCCACTTTTGCATTTATGTCGTTTCTAT
ATCAGAAAGCATTTACGAATAAATGTCGCCAGAAACTTTCTCCAAATGGA
TGATGCAGTTAATTATGATCTCTCGATGAAAATCGACCAATTAAACATAC
CTGAGTATTTAAAAATGTATTTGAAAAATGGCTCATTTCAAAGGTAGTAG
TGGTAGTCTTTATTTATATTTTCCCACTGCCCACCGACAATTATTGATAA
TGAATGGAGTCAAATGCCTCAATCTACTCAGTTTTTATTTTCTTGTTATT
TTAATATTATTTTTTTGTGAATACCTATTGATCGAC
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protein sequence of SMED30025986-orf-1

>SMED30025986-orf-1 ID=SMED30025986-orf-1|Name=SMED30025986-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=314bp
MPEHDECEFCMSSKRMRTSYRSNSNNNNNLVTVSRHYYDKCPPRLLQLMD
IPHFTYKMQLAYAWNPLDSSINIDVKLIDPLTLHRHPVAQSTDSIRGKIG
FNRGFHMWRIDWKLRERGTHAVVGVCTKDAPLHCHGYCSLIGLTEESWGW
DIIRKKLVHKQSVDVEDQTYPVIIADDICSLGDAIERPNTNIEVQESIFV
LLDMEEGTLSFINDGQYLGVAFSGLKGRTLYPAISAVWGHCEVTMAHLAS
LNPLPLPLLHLCRFYIRKHLRINVARNFLQMDDAVNYDLSMKIDQLNIPE
YLKMYLKNGSFQR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR043136B30.2/SPRY_sf
IPR003877SPRY_dom
IPR001496SOCS_box
IPR001870B30.2/SPRY
IPR013320ConA-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: biological process
TermDefinition
GO:0035556intracellular signal transduction
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001496SOCS box domainSMARTSM00969SOCS_box_2coord: 255..309
e-value: 0.0017
score: 27.6
IPR001496SOCS box domainPFAMPF07525SOCS_boxcoord: 255..307
e-value: 1.5E-8
score: 34.8
IPR001496SOCS box domainPROSITEPS50225SOCScoord: 255..312
score: 10.293
IPR003877SPRY domainSMARTSM00449SPRY_3coord: 103..249
e-value: 2.3E-10
score: 50.4
IPR003877SPRY domainPFAMPF00622SPRYcoord: 106..245
e-value: 3.9E-18
score: 65.7
IPR043136B30.2/SPRY domain superfamilyGENE3DG3DSA:2.60.120.920coord: 78..247
e-value: 2.1E-25
score: 91.3
NoneNo IPR availablePANTHERPTHR12245SPRY DOMAIN CONTAINING SOCS BOX PROTEINcoord: 19..307
NoneNo IPR availablePANTHERPTHR12245:SF11PROTEIN GUSTAVUScoord: 19..307
NoneNo IPR availableCDDcd12906SPRY_SOCS1-2-4coord: 62..247
e-value: 6.2762E-116
score: 329.971
IPR001870B30.2/SPRY domainPROSITEPS50188B302_SPRYcoord: 42..252
score: 11.773
IPR013320Concanavalin A-like lectin/glucanase domain superfamilySUPERFAMILYSSF49899Concanavalin A-like lectins/glucanasescoord: 42..266