c-SKI_SMAD_bind domain-containing protein

Overview
Namec-SKI_SMAD_bind domain-containing protein
Smed IDSMED30025907
Length (bp)2806
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of c-SKI_SMAD_bind domain-containing protein (SMED30025907) t-SNE clustered cells

Violin plots show distribution of expression levels for c-SKI_SMAD_bind domain-containing protein (SMED30025907) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of c-SKI_SMAD_bind domain-containing protein (SMED30025907) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for c-SKI_SMAD_bind domain-containing protein (SMED30025907) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025907

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30025907SMESG000075612.1 SMESG000026079.1 SMESG000018825.1 SMESG000002232.1 dd_Smed_v4_6759_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025907SMESG000075612.1 SMESG000026079.1 SMESG000018825.1 SMESG000002232.1 dd_Smed_v4_6759_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30025907SMESG000075612.1 SMESG000026079.1 SMESG000018825.1 SMESG000002232.1 dd_Smed_v4_6759_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025907SMESG000075612.1 SMESG000018825.1 Contig12131uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025907SMESG000075612.1 SMESG000018825.1 Contig12131newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025907SMESG000075612.1 SMESG000018825.1 SMESG000002232.1 Contig55157uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025907SMESG000075612.1 SMESG000018825.1 SMESG000002232.1 Contig55157newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
epidermisSMED30025907SMESG000075612.1 SMESG000026079.1 SMESG000018825.1 SMESG000002232.1 dd_Smed_v4_6759_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30025907SMESG000023294.1 SMESG000018825.1 dd_Smed_v4_9053_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKI (SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10896])

HSP 1 Score: 142.895 bits (359), Expect = 2.611e-34
Identity = 79/195 (40.51%), Postives = 107/195 (54.87%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF------QPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPEN 976
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L        P +     S A      + S++V H CFG+ +G+L P LY+S  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT  E 
Sbjct:  103 TVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLSQDYTGKEE 296
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 127.872 bits (320), Expect = 7.956e-30
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:  144 LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 331
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 127.872 bits (320), Expect = 1.019e-29
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:  124 LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 311
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 127.872 bits (320), Expect = 1.128e-29
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:  144 LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 331
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Match: SKIL (SKI like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897])

HSP 1 Score: 127.872 bits (320), Expect = 1.128e-29
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:  144 LTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 331
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0343409)

HSP 1 Score: 134.035 bits (336), Expect = 1.975e-31
Identity = 79/213 (37.09%), Postives = 110/213 (51.64%), Query Frame = 2 
Query:  404 GTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTI---SEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKAL 1033
            G L    +E + I  F+V GE R+CLPQ L  VL +F +  I++   +L I C QC + Q+      +I P  +   GLI ++DAERLC  L   +   S +   S A   L    S  V H CFG+  GI  P +Y+     CIKC  C+ +F   +FVGH H+  E ++T HWGFDS NW   L +  D EN     +     ILD++K +
Sbjct:  114 GELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALLHRSDRNSYVPIESLAKGAL----SFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQI-----ILDQLKEV 316
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0112717)

HSP 1 Score: 134.035 bits (336), Expect = 1.975e-31
Identity = 79/213 (37.09%), Postives = 110/213 (51.64%), Query Frame = 2 
Query:  404 GTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTI---SEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKAL 1033
            G L    +E + I  F+V GE R+CLPQ L  VL +F +  I++   +L I C QC + Q+      +I P  +   GLI ++DAERLC  L   +   S +   S A   L    S  V H CFG+  GI  P +Y+     CIKC  C+ +F   +FVGH H+  E ++T HWGFDS NW   L +  D EN     +     ILD++K +
Sbjct:  114 GELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALLHRSDRNSYVPIESLAKGAL----SFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQI-----ILDQLKEV 316
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0112719)

HSP 1 Score: 134.035 bits (336), Expect = 1.975e-31
Identity = 79/213 (37.09%), Postives = 110/213 (51.64%), Query Frame = 2 
Query:  404 GTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTI---SEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKAL 1033
            G L    +E + I  F+V GE R+CLPQ L  VL +F +  I++   +L I C QC + Q+      +I P  +   GLI ++DAERLC  L   +   S +   S A   L    S  V H CFG+  GI  P +Y+     CIKC  C+ +F   +FVGH H+  E ++T HWGFDS NW   L +  D EN     +     ILD++K +
Sbjct:  114 GELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALLHRSDRNSYVPIESLAKGAL----SFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQI-----ILDQLKEV 316
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: Snoo (gene:FBgn0085450 transcript:FBtr0112718)

HSP 1 Score: 134.035 bits (336), Expect = 1.975e-31
Identity = 79/213 (37.09%), Postives = 110/213 (51.64%), Query Frame = 2 
Query:  404 GTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTI---SEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKAL 1033
            G L    +E + I  F+V GE R+CLPQ L  VL +F +  I++   +L I C QC + Q+      +I P  +   GLI ++DAERLC  L   +   S +   S A   L    S  V H CFG+  GI  P +Y+     CIKC  C+ +F   +FVGH H+  E ++T HWGFDS NW   L +  D EN     +     ILD++K +
Sbjct:  114 GELYETKLEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCAALLHRSDRNSYVPIESLAKGAL----SFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFE-NHTCHWGFDSRNWHDYLHVALDVENREKYQI-----ILDQLKEV 316
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Match: fuss (gene:FBgn0039932 transcript:FBtr0301336)

HSP 1 Score: 98.2117 bits (243), Expect = 1.505e-20
Identity = 57/176 (32.39%), Postives = 84/176 (47.73%), Query Frame = 2 
Query:  440 IAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDS---NNWRLLLQI 958
            I   ++ G+ R+CL Q+   +L +F  N I      L I C QC   Q+++L      P    RCG+I + +AERLCK     N           +L    +  V H C    RG   P  YNSS AKCIKC+ C  FF   +F+ H+H++   +N  +   D+   N+WR  + +
Sbjct:   36 IVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPVSSRRCGMITRREAERLCKSFLGDN--------TPPRLPDDFAFNVQHKCAWGCRGSFLPSRYNSSRAKCIKCSYCGMFFSPNKFIFHSHRI--TTNDRYVQPDAANFNSWRRHMSL 201
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skila (SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GENE-070912-548])

HSP 1 Score: 141.739 bits (356), Expect = 1.287e-35
Identity = 79/217 (36.41%), Postives = 116/217 (53.46%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQ-------ESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYY 1039
            L ++++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C+ +Q+ +L    I P +   CGLI  +DA+RLC  L +P  N S  ++ N KL  Q        S QV H C G+ +G+  P  Y   DA CI+C  C+  F    FV H+HK  +   T HWGFDS  W   LQ+    E    E     K +LD++K  ++
Sbjct:  154 LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGANIS--ADPNSKLPGQGLLKESDASFQVEHQCLGKCQGLFVPHFYVQPDAPCIQCMECQLLFSPQNFVMHSHKSPD-KRTCHWGFDSAKWPCYLQLGRKHEGTQEE--PQLKQLLDEMKEKFH 365
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skila (SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GENE-070912-548])

HSP 1 Score: 140.584 bits (353), Expect = 2.623e-35
Identity = 79/217 (36.41%), Postives = 116/217 (53.46%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQ-------ESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYY 1039
            L ++++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C+ +Q+ +L    I P +   CGLI  +DA+RLC  L +P  N S  ++ N KL  Q        S QV H C G+ +G+  P  Y   DA CI+C  C+  F    FV H+HK  +   T HWGFDS  W   LQ+    E    E     K +LD++K  ++
Sbjct:  133 LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGANIS--ADPNSKLPGQGLLKESDASFQVEHQCLGKCQGLFVPHFYVQPDAPCIQCMECQLLFSPQNFVMHSHKSPD-KRTCHWGFDSAKWPCYLQLGRKHEGTQEE--PQLKQLLDEMKEKFH 344
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skia (v-ski avian sarcoma viral oncogene homolog a [Source:ZFIN;Acc:ZDB-GENE-990715-9])

HSP 1 Score: 144.05 bits (362), Expect = 5.655e-35
Identity = 87/226 (38.50%), Postives = 121/226 (53.54%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPENGNV--EMLNDKKSILD-----KVKALYYEDEI 1051
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    DL I C +C   Q+++L    I P     CGLI K+DAERLC  L     + P+           +L+++ S ++ H CFG+ +G+L P LY S +A CI+C  C   + T +FV H+HK  E + T HWGFDS NWR   LL   YT  E      ++L+D K   D     K KA    D I
Sbjct:   86 TVLEGETISCFVVGGEKRLCLPQILNTVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFAAPSCGLITKTDAERLCNALIYGGTYPPHSKKELYGSIELELTEK-SFKIYHECFGKCKGLLVPELYTSPNAPCIQCMDCRLMYPTHKFVVHSHKSLE-NRTCHWGFDSANWRAYVLLSPDYTGKEEKARLEQLLDDIKEKFDFSNKYKRKASQASDPI 309
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skib (v-ski avian sarcoma viral oncogene homolog b [Source:ZFIN;Acc:ZDB-GENE-990715-10])

HSP 1 Score: 143.28 bits (360), Expect = 8.270e-35
Identity = 81/201 (40.30%), Postives = 117/201 (58.21%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTD-PENGNVEML 994
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    DL I C +C   Q+++L    I P     CGLI ++DAERLC  L     F P+ +   +S + +    ++S +V H CFG+ +G+  P LY S +A CI+C  C   F T +FV H+HK  E + T HWGFDS+NWR   LL Q Y++  EN  ++ L
Sbjct:   82 TVLERETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFSAPSCGLITQTDAERLCNALIYGGTFPPHAD-KELSCSIELERTEKSFKVYHECFGKCKGLFVPELYTSPNAACIQCLDCRLMFPTHKFVVHSHKRLE-NRTCHWGFDSSNWRAYILLDQDYSEKEENSTLQQL 280
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Match: skila (SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GENE-070912-548])

HSP 1 Score: 140.584 bits (353), Expect = 4.528e-34
Identity = 79/217 (36.41%), Postives = 116/217 (53.46%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQ-------ESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYY 1039
            L ++++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C+ +Q+ +L    I P +   CGLI  +DA+RLC  L +P  N S  ++ N KL  Q        S QV H C G+ +G+  P  Y   DA CI+C  C+  F    FV H+HK  +   T HWGFDS  W   LQ+    E    E     K +LD++K  ++
Sbjct:  108 LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGANIS--ADPNSKLPGQGLLKESDASFQVEHQCLGKCQGLFVPHFYVQPDAPCIQCMECQLLFSPQNFVMHSHKSPD-KRTCHWGFDSAKWPCYLQLGRKHEGTQEE--PQLKQLLDEMKEKFH 319
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: SKI (SKI proto-oncogene [Source:NCBI gene;Acc:100486949])

HSP 1 Score: 135.961 bits (341), Expect = 3.646e-32
Identity = 80/223 (35.87%), Postives = 117/223 (52.47%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPN-QNYSTISEANQKLSQQE-SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTD-PENGNVEMLNDKKSILDKVKALY-YEDEIKKR 1060
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C   Q+++L    I P     CGLI K+DAERLC  L     + P     S       +L   E S +V H CFG+ RG+  P LY    A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR  + +  D P  G  E       +L+++K  + Y ++ K++
Sbjct:   86 TILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHVYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGSYPPRCAKKSDFPPGPLELELTESSFRVYHECFGKCRGLFVPELYGHPSAPCIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLARDNPGAGGEEEQARLSRLLEEMKEKFDYSNKYKRK 307
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000042147.1 (SKI-like proto-oncogene [Source:NCBI gene;Acc:100492636])

HSP 1 Score: 127.487 bits (319), Expect = 1.222e-29
Identity = 70/194 (36.08%), Postives = 103/194 (53.09%), Query Frame = 2 
Query:  425 IENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE---SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI---YTDPENG 979
            +E E I+ F V GE+R+CLPQ+L  VL +F +  I+    ++ I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +   N     +E   + +V H C G+ +G+  P L++  DA CI+C  C   F T  FV H+H+  +   T HWGFDS  W   + +   Y D   G
Sbjct:  131 LEGESISCFMVGGEKRLCLPQVLNSVLRDFSLQQINIVCDEMYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPQTFPQNGSLLPAKNSLAQLKETGSAFEVEHDCLGKCQGLFAPHLFSQPDAPCIQCLECYGMFSTQTFVMHSHRSPD-KRTCHWGFDSAKWHCYVHLSPKYLDTPEG 323
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: arg1 (arginase 1 [Source:Xenbase;Acc:XB-GENE-966913])

HSP 1 Score: 98.5969 bits (244), Expect = 5.466e-22
Identity = 60/187 (32.09%), Postives = 85/187 (45.45%), Query Frame = 2 
Query:  461 GERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIY-TDPENGNVEMLNDKKSILD 1018
            G+ R+CL Q+   +L  +  N I      L I C QC   Q+++L      P    RCG+I K +AERLCK     N+          KL    +  V H C    RG   P  YNSS AKCIKC  C  +F   +F+ H+H+  E         + N+WR  L++    P +  V    D K++ +
Sbjct:   58 GQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGENRP--------PKLPDNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCTYCNMYFSPNKFIFHSHRTPEAKYMQPDAANFNSWRRHLKLSDKTPSDDMVFAWEDVKAMFN 236
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: SKOR1 (SKI family transcriptional corepressor 1 [Source:NCBI gene;Acc:100491438])

HSP 1 Score: 101.679 bits (252), Expect = 1.798e-21
Identity = 60/190 (31.58%), Postives = 88/190 (46.32%), Query Frame = 2 
Query:  404 GTLDYNMIENELIAGFNVW-----GERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            G+L  N +    + G  +      G+ R+CL Q+   +L  +  N I      L I C QC   Q+++L      P    RCG+I K +AERLCK     ++          KL +  +  V H C    RG   P  YNSS AKCIKCA C  +F   +F+ H+H+  +   T     + N+WR  L++
Sbjct:   30 GSLKPNQVGETCLYGVPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHRP--------PKLPENFAFDVAHECAWGCRGSFIPARYNSSRAKCIKCAYCGLYFSPNKFIFHSHRTPDSKYTQPDAANFNSWRRHLRL 211
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Match: SKOR1 (SKI family transcriptional corepressor 1 [Source:NCBI gene;Acc:100491438])

HSP 1 Score: 101.679 bits (252), Expect = 2.199e-21
Identity = 60/190 (31.58%), Postives = 88/190 (46.32%), Query Frame = 2 
Query:  404 GTLDYNMIENELIAGFNVW-----GERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            G+L  N +    + G  +      G+ R+CL Q+   +L  +  N I      L I C QC   Q+++L      P    RCG+I K +AERLCK     ++          KL +  +  V H C    RG   P  YNSS AKCIKCA C  +F   +F+ H+H+  +   T     + N+WR  L++
Sbjct:   30 GSLKPNQVGETCLYGVPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHRP--------PKLPENFAFDVAHECAWGCRGSFIPARYNSSRAKCIKCAYCGLYFSPNKFIFHSHRTPDSKYTQPDAANFNSWRRHLRL 211
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Ski (ski sarcoma viral oncogene homolog (avian) [Source:MGI Symbol;Acc:MGI:98310])

HSP 1 Score: 142.51 bits (358), Expect = 1.880e-34
Identity = 84/223 (37.67%), Postives = 118/223 (52.91%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF------QPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKR 1060
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L        P +     S A      + S++V H CFG+ +G+L P LY+S  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT    G  E     + + D  +   Y ++ K+R
Sbjct:  103 TVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLSQDYT----GKEEQARLGRCLDDVKEKFDYANKYKRR 320
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Ski (ski sarcoma viral oncogene homolog (avian) [Source:MGI Symbol;Acc:MGI:98310])

HSP 1 Score: 140.969 bits (354), Expect = 4.743e-34
Identity = 84/220 (38.18%), Postives = 116/220 (52.73%), Query Frame = 2 
Query:  428 ENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF------QPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKR 1060
            E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L        P +     S A      + S++V H CFG+ +G+L P LY+S  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT    G  E     + + D  +   Y ++ K+R
Sbjct:   54 EGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLSQDYT----GKEEQARLGRCLDDVKEKFDYANKYKRR 268
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Skil (SKI-like [Source:MGI Symbol;Acc:MGI:106203])

HSP 1 Score: 127.487 bits (319), Expect = 3.514e-30
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:   61 LTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 248
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Skil (SKI-like [Source:MGI Symbol;Acc:MGI:106203])

HSP 1 Score: 127.872 bits (320), Expect = 4.935e-30
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:  141 LTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 328
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Match: Skil (SKI-like [Source:MGI Symbol;Acc:MGI:106203])

HSP 1 Score: 127.872 bits (320), Expect = 6.664e-30
Identity = 70/190 (36.84%), Postives = 101/190 (53.16%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPN---QNYSTISEANQKLSQQE----SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L   ++E E I+ F V GE+R+CLPQ+L  VL EF +  I+    +L I C +C + Q+ +L    I P +   CGLI  +DA+RLC  L +P    QN S +  A   L+Q +    + +V H C G+ +G+  P  Y   DA CI+C  C   F    FV H+H+  +   T HWGF+S  W   L +
Sbjct:  141 LTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILP-AKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHV 328
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|P17863|SKI_AVIES (Transforming protein Ski OS=Avian erythroblastosis virus (strain Sloan-Kettering) OX=11862 GN=V-SKI PE=1 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 3.772e-34
Identity = 87/241 (36.10%), Postives = 129/241 (53.53%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPENGNV--EMLNDKKSILD-----KVKALYYEDEIK---KRNQTNINLVW 1087
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L     + P+      S    +L+++ S +V H CFG+ +G+L P LY++  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT  E      ++L++ K   D     K KA    +  +   +RN+    ++W
Sbjct:   65 TILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGTYPPHCKKEFSSTIELELTEK-SFKVYHECFGKCKGLLVPELYSNPSAACIQCLDCRLMYPPHKFVVHSHKSLE-NRTCHWGFDSANWRSYILLSQDYTGKEEKARLGQLLDEMKEKFDYNNKYKRKAPRNRESPRVQLRRNKMFKTMLW 303
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|P12755|SKI_HUMAN (Ski oncogene OS=Homo sapiens OX=9606 GN=SKI PE=1 SV=1)

HSP 1 Score: 142.895 bits (359), Expect = 1.254e-33
Identity = 79/195 (40.51%), Postives = 107/195 (54.87%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF------QPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPEN 976
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L        P +     S A      + S++V H CFG+ +G+L P LY+S  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT  E 
Sbjct:  103 TVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLSQDYTGKEE 296
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|Q60698|SKI_MOUSE (Ski oncogene OS=Mus musculus OX=10090 GN=Ski PE=1 SV=2)

HSP 1 Score: 142.51 bits (358), Expect = 1.278e-33
Identity = 84/223 (37.67%), Postives = 118/223 (52.91%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF------QPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKR 1060
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L        P +     S A      + S++V H CFG+ +G+L P LY+S  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT    G  E     + + D  +   Y ++ K+R
Sbjct:  101 TVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLSQDYT----GKEEQARLGRCLDDVKEKFDYANKYKRR 318
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9TUG2|SKI_HORSE (Ski oncogene OS=Equus caballus OX=9796 GN=SKI PE=2 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 6.338e-33
Identity = 78/195 (40.00%), Postives = 106/195 (54.36%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF------QPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPEN 976
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L   C +C   Q+++L    I P     CGLI K+DAERLC  L        P +     S A      + S++V H CFG+ +G+L P LY+S  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT  E 
Sbjct:  103 TVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHTYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALE-NRTCHWGFDSANWRAYILLSQDYTGKEE 296
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Match: sp|P49140|SKI_CHICK (Ski oncogene OS=Gallus gallus OX=9031 GN=SKI PE=1 SV=1)

HSP 1 Score: 139.813 bits (351), Expect = 1.204e-32
Identity = 78/194 (40.21%), Postives = 110/194 (56.70%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPEN 976
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L     + P+      S    +L+++ S +V H CFG+ +G+L P LY++  A CI+C  C   +   +FV H+HK  E + T HWGFDS NWR   LL Q YT  E 
Sbjct:   86 TILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGTYPPHCKKEFSSTIELELTEK-SFKVYHECFGKCKGLLVPELYSNPSAACIQCLDCRLMYPPHKFVVHSHKSLE-NRTCHWGFDSANWRSYILLSQDYTGKEE 277
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A564YIS2 (c-SKI_SMAD_bind domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6350 PE=4 SV=1)

HSP 1 Score: 201.83 bits (512), Expect = 1.153e-49
Identity = 93/216 (43.06%), Postives = 130/216 (60.19%), Query Frame = 2 
Query:  392 FEDPGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-------------FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLND 1000
             E+ G L Y+++E E + GFNVWGE R+CLP LLRFVL + DI+ I QA++ LRI C +C+++Q+ MLH     P  +  CGLIRKSDAER+ K+L              +P ++   +  A ++ S    I V H CFG ++G +YP LY S+++ CI C TC   F   +FVGHTH ++E  +  HWGFDS NWR  LQ+  DP   + +   D
Sbjct:  141 IEETGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSHRQLAMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADAEIRPPESAEGLKTAKEEASLGNYIDVRHDCFGTEKGRIYPHLYASANSPCIACRTCNKLFSPQDFVGHTHSVNESDSCCHWGFDSTNWRSYLQLDIDPSTRHKKAKRD 356
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A564YIK6 (c-SKI_SMAD_bind domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS6350 PE=4 SV=1)

HSP 1 Score: 201.83 bits (512), Expect = 1.239e-49
Identity = 92/206 (44.66%), Postives = 127/206 (61.65%), Query Frame = 2 
Query:  392 FEDPGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-------------FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDP 970
             E+ G L Y+++E E + GFNVWGE R+CLP LLRFVL + DI+ I QA++ LRI C +C+++Q+ MLH     P  +  CGLIRKSDAER+ K+L              +P ++   +  A ++ S    I V H CFG ++G +YP LY S+++ CI C TC   F   +FVGHTH ++E  +  HWGFDS NWR  LQ+  DP
Sbjct:  141 IEETGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSHRQLAMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADAEIRPPESAEGLKTAKEEASLGNYIDVRHDCFGTEKGRIYPHLYASANSPCIACRTCNKLFSPQDFVGHTHSVNESDSCCHWGFDSTNWRSYLQLDIDP 346
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A0R3SIW8 (c-SKI_SMAD_bind domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS4881 PE=4 SV=1)

HSP 1 Score: 201.83 bits (512), Expect = 1.477e-49
Identity = 92/206 (44.66%), Postives = 127/206 (61.65%), Query Frame = 2 
Query:  392 FEDPGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-------------FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDP 970
             E+ G L Y+++E E + GFNVWGE R+CLP LLRFVL + DI+ I QA++ LRI C +C+++Q+ MLH     P  +  CGLIRKSDAER+ K+L              +P ++   +  A ++ S    I V H CFG ++G +YP LY S+++ CI C TC   F   +FVGHTH ++E  +  HWGFDS NWR  LQ+  DP
Sbjct:  141 IEETGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLYDVDIDEIGQALSKLRIACTKCSHRQLAMLHGCNALPAEVTSCGLIRKSDAERMLKFLRSSRERPTLADAEIRPPESAEGLKTAKEEASLGNYIDVRHDCFGTEKGRIYPHLYASANSPCIACRTCNKLFSPQDFVGHTHSVNESDSCCHWGFDSTNWRSYLQLDIDP 346
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A504YBK6 (c-SKI_SMAD_bind domain-containing protein OS=Fasciola gigantica OX=46835 GN=FGIG_11203 PE=4 SV=1)

HSP 1 Score: 199.134 bits (505), Expect = 1.882e-48
Identity = 104/269 (38.66%), Postives = 135/269 (50.19%), Query Frame = 2 
Query:  368 KTRMSIEVFEDPGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLF-----------------------------------QPNQNYSTISEA-------NQKLSQQESIQ----------------------------VVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYT 964
            K + S E+  + GTL  ++I+ E+I GFNVWGE+R+CLP L RFVL + D+  ID+A T L+I C  C   Q+K+LH   I PK +  CGLIRKSDAERL KY+                                    Q  Q Y T+S +       +Q++S   S Q                            V+H CFG Q G+++P LY    AKCI+C TC   F   +FVGHTH + EV N  HWGFDSNNWR  L++YT
Sbjct:  186 KHQASPELAPETGTLVPSLIDGEVIMGFNVWGEKRLCLPHLFRFVLNDVDLKAIDEACTKLQITCTTCTPAQLKLLHSRRILPKAVSTCGLIRKSDAERLTKYIRNRADLADRVQANTRLNPGVIRSHSGSQLEVIASEDQAKQPYPTVSRSGSLSLKRSQEISDNHSAQLDLVGGNECVRKRDDSVEPRSDSDDPIPVLHECFGRQSGLIHPELYTEPTAKCIECQTCHRLFAPDQFVGHTHTVTEVDNLNHWGFDSNNWRCYLRLYT 454
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Match: A0A0R3VSN9 (c-SKI_SMAD_bind domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS192 PE=4 SV=1)

HSP 1 Score: 197.208 bits (500), Expect = 4.322e-48
Identity = 95/215 (44.19%), Postives = 122/215 (56.74%), Query Frame = 2 
Query:  392 FEDPGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----------------------FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTD 967
             E+ G L Y+++E E + GFNVWGE R+CLP LLRFVL + DI+ I QA++ LRI C +C+ +Q+ MLH     P  +  CGLIRKSDAER+ K+L                       F P Q     S   + ++ +  I V H CFG QRG +YP LYNS  + CI C TC   F   +FVGHTH ++E     HWGFDS NWR  LQ+  D
Sbjct:  134 IEETGELVYSIVEGEKVMGFNVWGEVRLCLPHLLRFVLNDVDIDEIGQAISKLRIACTKCSPRQLAMLHGCNALPGEVTSCGLIRKSDAERMLKFLRSSRRRPTLADACPNVNATDGRTFVPEQTGGKKSAEERDVTLENFIDVRHDCFGTQRGRVYPHLYNSVTSPCIVCRTCNTLFSPQDFVGHTHSVNESDGCCHWGFDSTNWRSYLQLDID 348
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skia (ski oncogene [Source:NCBI gene;Acc:103046211])

HSP 1 Score: 136.732 bits (343), Expect = 1.455e-32
Identity = 71/202 (35.15%), Postives = 102/202 (50.50%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQ------QESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKK 1006
             ++E E I+ F V GE+R+CLPQ+L  VL E  +  I+     L I C +C  +Q+++L    + P     CGLI K+DAERLC  L         +++  +  ++      +  I+V H CFG   G+L P LY S  A CI+CA C        FV H H   E + T HWGFDS+NWR  + +      G  +    +K
Sbjct:  108 TVLEGETISCFVVGGEKRLCLPQILNTVLRELSLQQINSVCDQLHIYCSRCTAEQLEILKVVGVLPFSAPSCGLITKTDAERLCNALVHGAGYPGKLAQEQEVEAEVHEGKAEAGIKVYHECFGRCAGVLLPELYTSPSAPCIRCAHCGLLLAPRRFVAHAHGTPE-NRTCHWGFDSDNWRAYVLLRASEYAGRSKRRRQRK 308
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skib (ski oncogene-like [Source:NCBI gene;Acc:103031474])

HSP 1 Score: 132.88 bits (333), Expect = 2.959e-31
Identity = 75/208 (36.06%), Postives = 112/208 (53.85%), Query Frame = 2 
Query:  422 MIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQE-SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR--LLLQIYTDPENGNVEMLNDKKSILDKVKALY 1036
            ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C  +Q+++L    + P     CGLI ++DAERLC  L       S    A  +L+  + S+ V H CFG   G+  P LY+   A C++CA C   F    FV H+H+  E + T HWGFDS NWR  +LL     P   + E+    +  LD++K  +
Sbjct:   84 VLERETISCFVVGGEKRLCLPQILNTVLRDFSLQQINAVCDELHVYCSRCTAEQLEVLKVVGVLPFSAPSCGLITQTDAERLCNALVHGGALPSRGGPAALELATTDKSVPVYHECFGRCDGVFVPELYSGPGAACVQCADCGLMFPARRFVVHSHRRRE-NRTCHWGFDSANWRAYILLDRDRAPPTEHTEL----QRRLDRLKEKF 286
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skib (ski oncogene-like [Source:NCBI gene;Acc:103031474])

HSP 1 Score: 132.88 bits (333), Expect = 3.840e-31
Identity = 75/208 (36.06%), Postives = 112/208 (53.85%), Query Frame = 2 
Query:  422 MIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQE-SIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR--LLLQIYTDPENGNVEMLNDKKSILDKVKALY 1036
            ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C  +Q+++L    + P     CGLI ++DAERLC  L       S    A  +L+  + S+ V H CFG   G+  P LY+   A C++CA C   F    FV H+H+  E + T HWGFDS NWR  +LL     P   + E+    +  LD++K  +
Sbjct:   84 VLERETISCFVVGGEKRLCLPQILNTVLRDFSLQQINAVCDELHVYCSRCTAEQLEVLKVVGVLPFSAPSCGLITQTDAERLCNALVHGGALPSRGGPAALELATTDKSVPVYHECFGRCDGVFVPELYSGPGAACVQCADCGLMFPARRFVVHSHRRRE-NRTCHWGFDSANWRAYILLDRDRAPPTEHTEL----QRRLDRLKEKF 286
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skila (SKI like proto-oncogene [Source:NCBI gene;Acc:103032490])

HSP 1 Score: 131.339 bits (329), Expect = 4.121e-31
Identity = 70/216 (32.41%), Postives = 110/216 (50.93%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKK 1057
            L ++++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C+ +Q+ +L    I P +   CGLI  +DA+RLC  L +P           +    +   QV H C G+ +G+  P  Y   DA CI+C  C+  F    FV H+H       T HWGFDS  W   LQ+    +    E     + +LD++K  ++   +K+
Sbjct:  149 LTHSILEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINAVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGTAIHVEQSMLKAKDSEAGFQVEHQCLGKCQGLFVPQFYVQPDAPCIRCMECQLLFSPQNFVMHSH-CSPDKRTCHWGFDSAKWACYLQLSRRYQGAAEE--PKLRQLLDEMKNKFHSPTLKR 361
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Match: skilb (ski-like protein [Source:NCBI gene;Acc:103027845])

HSP 1 Score: 120.553 bits (301), Expect = 1.028e-27
Identity = 62/187 (33.16%), Postives = 97/187 (51.87%), Query Frame = 2 
Query:  425 IENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQN---------YSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            +E E I+ F+V GE R+CLPQ+L  VL +F ++ I+     L + C +C+  Q+++L    + P     CGLI  +DA+RLC  L  P ++         +S   +  ++  +  +  V H C G+ +G+  P  Y S  + CI+C+ C   F    FV H+H   +   T HWGFDS  W   LQ+
Sbjct:  130 LEGETISCFSVGGELRLCLPQVLNTVLRDFSLHQINSVCDQLYLYCSRCDASQLQVLKILGVLPPGAPSCGLITLTDAQRLCNTLLHPGESNAPAGVLKGHSVGEDEEKEAEEGGAFWVEHQCLGKCQGLFVPRFYASPGSPCIRCSQCRRLFCPERFVMHSHWQPD-KRTCHWGFDSAKWACYLQL 315
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001301.1 (pep scaffold:Pmarinus_7.0:GL481803:9978:11426:-1 gene:ENSPMAG00000001172.1 transcript:ENSPMAT00000001301.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 100.523 bits (249), Expect = 1.802e-22
Identity = 56/186 (30.11%), Postives = 86/186 (46.24%), Query Frame = 2 
Query:  401 PGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            PG +   ++    I    + G+ R+CL Q+   +L  +  N I      L I C QC   Q+++L      P    RCG+I + +AERLCK     ++          +L +  +  V H C    RG   P  YNSS AKCIKC+ C  FF   +F+ H+H+  +         + N+WR  L++
Sbjct:    5 PGHVGEVLLYGAPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNRRVALGITCVQCTPVQLELLRRAGAMPVSSRRCGMITRREAERLCKSFLGDHEP--------PRLPENFAFDVTHECAWGCRGSFVPARYNSSRAKCIKCSLCGLFFSPNKFIFHSHRAPDAKYVQPDAANFNSWRRHLRL 182
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Nematostella
Match: EDO41836 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S373])

HSP 1 Score: 112.464 bits (280), Expect = 9.628e-29
Identity = 63/169 (37.28%), Postives = 87/169 (51.48%), Query Frame = 2 
Query:  461 GERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTD 967
            GE+R+C  +L+  +L  F   VI+     L+I C +C  QQ+++L    + P      GLI KSDA RL   L   N     +   N +L   +S++V H CFG   G L   LY    A+C+ C+ C+  F    FV H H   EV +T HWGFDS NW+L L +  D
Sbjct:    1 GEKRLCYKELVEKILKGFSSQVINATRDRLQIFCPRCTPQQLEVLKLAGVLPWSCASAGLIAKSDAFRLIGALTGSN-----VPHRNSRLFSVDSLEVYHECFGGCVGTLEIELYTDPYAECVTCSQCDGVFSPRTFVTHHHTSGEV-HTCHWGFDSANWKLYLMLCND 163
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skia (SKI proto-oncogene [Source:NCBI gene;Acc:101164645])

HSP 1 Score: 144.436 bits (363), Expect = 3.195e-35
Identity = 85/213 (39.91%), Postives = 113/213 (53.05%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLS-QQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYT-DPENGNVEMLNDKKSILDKVK 1027
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L     F P            +L     S +V H CFG+ +G+L P LY S  A CI+C  C   + T +FV H+HK  E + T HWGFDS NWR   LL Q YT   E   +E       ILD++K
Sbjct:   82 TVLEGETISCFVVGGEKRLCLPQILNTVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALIYGGAFPPRAKKELGGAGALELQLTDRSFKVYHECFGKCKGLLVPELYGSPSAACIQCLDCRLMYPTHKFVVHSHKAQE-NRTCHWGFDSANWRAYILLSQDYTGKEEKARLEQ------ILDEIK 287
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skia (SKI proto-oncogene [Source:NCBI gene;Acc:101164645])

HSP 1 Score: 144.436 bits (363), Expect = 4.141e-35
Identity = 85/213 (39.91%), Postives = 113/213 (53.05%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLS-QQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYT-DPENGNVEMLNDKKSILDKVK 1027
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L I C +C   Q+++L    I P     CGLI K+DAERLC  L     F P            +L     S +V H CFG+ +G+L P LY S  A CI+C  C   + T +FV H+HK  E + T HWGFDS NWR   LL Q YT   E   +E       ILD++K
Sbjct:   82 TVLEGETISCFVVGGEKRLCLPQILNTVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALIYGGAFPPRAKKELGGAGALELQLTDRSFKVYHECFGKCKGLLVPELYGSPSAACIQCLDCRLMYPTHKFVVHSHKAQE-NRTCHWGFDSANWRAYILLSQDYTGKEEKARLEQ------ILDEIK 287
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skib (ski oncogene [Source:NCBI gene;Acc:101171238])

HSP 1 Score: 140.584 bits (353), Expect = 5.949e-34
Identity = 79/194 (40.72%), Postives = 108/194 (55.67%), Query Frame = 2 
Query:  419 NMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYL-----FQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWR---LLLQIYTDPEN 976
             ++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    DL I C +C   Q+++L    I P     CGLI ++DAERLC  L     + P+ N    S   ++   + S +V H CFG  +G+  P LY+S  A CI+C  C   F   +FV H+HK  E + T HWGFDS+NWR   LL   YTD E 
Sbjct:   81 TVLEREPISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVVGILPFSAPSCGLITQTDAERLCNALIYGGTYPPHCNKDLGSLELERT--ERSFKVYHECFGRCKGLFVPELYSSPAAACIQCMDCRLMFPPHKFVVHSHKRLE-NRTVHWGFDSSNWRVYVLLDADYTDKEE 271
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skila (SKI like proto-oncogene [Source:NCBI gene;Acc:111949033])

HSP 1 Score: 132.494 bits (332), Expect = 2.626e-31
Identity = 69/187 (36.90%), Postives = 103/187 (55.08%), Query Frame = 2 
Query:  410 LDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLS----QQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            L ++++E E I+ F V GE+R+CLPQ+L  VL +F +  I+    +L + C +C+ +Q+ +L    I P +   CGLI  +DA+RLC  L +P        + + KLS     + S QV H C G  +G+  P  Y+  +A CI+C  C+  F    FV H+HK  +   T HWGFDS  W   LQ+
Sbjct:  147 LTHSLLEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINTVCDELYVYCSRCDAEQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPGAVLPP--DPSGKLSVLKESETSFQVEHQCLGMCQGLFAPQFYSQPEAPCIQCVECQLLFSPQTFVMHSHKSPD-KRTCHWGFDSAKWPCYLQL 330
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Match: skor1b (SKI family transcriptional corepressor 1 [Source:NCBI gene;Acc:101171078])

HSP 1 Score: 103.219 bits (256), Expect = 4.024e-22
Identity = 57/173 (32.95%), Postives = 82/173 (47.40%), Query Frame = 2 
Query:  440 IAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQI 958
            I    + G+ R+CL Q+   +L  +  N I      L I C QC   Q+++L      P    RCG+I K +AERLCK            + +  KL +  +  V H C    RG   P  YNSS AKCIKC+ C  +F   +F+ H+H+  E   T     + N+WR  L++
Sbjct:   56 IVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLG--------AHSPPKLPENFAFDVSHECAWGSRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPESKYTQPDAANFNSWRRHLKL 220
[Close]
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000018825.1 (SMESG000018825.1)

HSP 1 Score: 1068.53 bits (2762), Expect = 0.000e+0
Identity = 600/619 (96.93%), Postives = 601/619 (97.09%), Query Frame = 2 
Query:  422 MIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKRNQTNINLVWXXXXXXXXXXXXXXXXXXXXXXHLRDGLADVYRKTSNSSLNVSKFDKLSNNNFVPNVYLQPPDGNLVNADTGNXXXXXXXXXXFSVKVIKCPNDPAMNAALQIKKESVNKDGLSLGTISAFLNKKEFTXXXXXXXXXXXXXXXXKFGKHENGLVIVAQSATSIPPQFLMLEALWSQLFRDIIQLTHLVHFNTNDERNRIVGQLMRCQDLFRTQWADLAEENQLLKEKLFQEQNRRQEIENLHEKMSISLKELTMEKSNLNEIIKQLESECEKLRSEIKPFIESERLMDSAMNKDSQKPDSNIEIEVYNWCRAGCKRNRSGSSSDESEXXXXXXXXXXXXISAHGSDRADLSDKPTSSCKQMRLSTTEKKLLGGSGXXXXXXXXXXXXPTNINDNESQ 2278
            MIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISE NQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKRNQTNINLVWRPSRKFKLP PPKPNFNSPKPPHLRDGLADVYRKTSNSSLNVSKFDKLSNNNFVPNVYLQPPDGNLVNADTGNDDDDIDDYDDFSVKVIKCPNDPAMNAALQIKKESVNKDGLSLGTISAFLNKKEFTNINHNEQPNN               +IVAQSATSIPPQFLMLEALWSQLFRDIIQLTHLVHFNTNDERNRIVGQLMRCQDLFRTQWADLAEENQLLKEKLFQEQNRRQEIENLHEKMSISLKELTMEKSNLNEIIKQLESECEKLRSEIKPFIESERLMDSAMNKDSQKPDSNIEIEVYNWCRAGCKRNRSGSSSDESEHQQRQFHNHHHFISAHGSDRADLSDK TSSCKQMRLSTTEKKLLGGSGINVDVNDNFVIVPTNINDNESQ
Sbjct:    1 MIENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISETNQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKRNQTNINLVWRPSRKFKLPNPPKPNFNSPKPPHLRDGLADVYRKTSNSSLNVSKFDKLSNNNFVPNVYLQPPDGNLVNADTGNDDDDIDDYDDFSVKVIKCPNDPAMNAALQIKKESVNKDGLSLGTISAFLNKKEFTNINHNEQPNN---------------IIVAQSATSIPPQFLMLEALWSQLFRDIIQLTHLVHFNTNDERNRIVGQLMRCQDLFRTQWADLAEENQLLKEKLFQEQNRRQEIENLHEKMSISLKELTMEKSNLNEIIKQLESECEKLRSEIKPFIESERLMDSAMNKDSQKPDSNIEIEVYNWCRAGCKRNRSGSSSDESEHQQRQFHNHHHFISAHGSDRADLSDKATSSCKQMRLSTTEKKLLGGSGINVDVNDNFVIVPTNINDNESQ 604
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000002232.1 (SMESG000002232.1)

HSP 1 Score: 271.166 bits (692), Expect = 1.240e-83
Identity = 136/190 (71.58%), Postives = 149/190 (78.42%), Query Frame = 2 
Query:  491 LRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKKR 1060
            +R  LPEFD NVIDQ VTDLRINCFQCNNQQIKML DNEIF KHIVRCG+IRKSDAERLCKYLFQPNQNYSTI++    L+ +   + + T   E + +LYPVLY+SSDAKCIKCAT                  EVSNTF WGFDSNNWRLLLQIYTDPENGNVEM+ND KS+LDKVKALYYEDEIKKR
Sbjct:    1 MRLTLPEFDFNVIDQVVTDLRINCFQCNNQQIKMLRDNEIFLKHIVRCGIIRKSDAERLCKYLFQPNQNYSTITKC---LANKNRFR-LFTRVLENKVVLYPVLYSSSDAKCIKCAT-----------------YEVSNTFRWGFDSNNWRLLLQIYTDPENGNVEMINDMKSVLDKVKALYYEDEIKKR 169
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000037051.1 (SMESG000037051.1)

HSP 1 Score: 171.785 bits (434), Expect = 4.846e-49
Identity = 88/140 (62.86%), Postives = 97/140 (69.29%), Query Frame = 2 
Query:  623 IVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYE 1042
            +V CG IRKSD E  CKYL         +     KL Q    QV H   GEQRG+L+P+LYNSSDAKCI CA CEN FKTFEF+ HTHKLDEVSNTFHWGF SNNWRLLLQ+Y DPEN  VE+LND KSIL K   +  E
Sbjct:   10 LVGCGPIRKSDTECSCKYL--------PLLSNPTKLQQN---QVAHPYPGEQRGVLHPMLYNSSDAKCINCAMCENLFKTFEFIDHTHKLDEVSNTFHWGFCSNNWRLLLQVYVDPENAIVEVLNDMKSILQKTAMMKCE 138
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000070642.1 (SMESG000070642.1)

HSP 1 Score: 155.992 bits (393), Expect = 8.631e-41
Identity = 83/212 (39.15%), Postives = 123/212 (58.02%), Query Frame = 2 
Query:  425 IENELIAGFNVWGERRICLPQLLRFVLPEFDINVIDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKYLFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKCIKCATCENFFKTFEFVGHTH-KLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSILDKVKALYYEDEIKK 1057
            +EN  +  F      +I +P L+R    + D   I+Q +T L I C QC  +Q+++LH  +I    + +CGLI K DA+RLCK++   N N ++I       S    I ++H CFG Q+  LYP LY  S+++CIKCA+C   F T EFV HTH K++ + NT HWGF S NWR  + IY    N +VE   +   ILD +K+ + ++++KK
Sbjct:   11 LENHFLISFANGSNIKILMPHLIRSFFQDIDYPTINQLLTFLSIKCCQCTPEQLRILHTTKILSSDVNQCGLIDKVDAKRLCKFIH--NTNLTSIRST----SSLFVIPIIHYCFGRQQAFLYPDLYVKSNSRCIKCASCSQIFTTCEFVKHTHLKINHI-NTVHWGFHSLNWRYFIYIYI--FNADVEYHKNATLILDNIKSAFLKEDMKK 213
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Match: SMESG000075612.1 (SMESG000075612.1)

HSP 1 Score: 137.887 bits (346), Expect = 1.226e-37
Identity = 63/69 (91.30%), Postives = 64/69 (92.75%), Query Frame = 2 
Query:  806 NSSDAKCIKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPENGNVEMLNDKKSI 1012
            NSSDAKC+KC TCENFFKTFEFV HTHKLDEVSNTF WGFDSNNWRLLLQIYTDPENG VEMLND KSI
Sbjct:   64 NSSDAKCVKCVTCENFFKTFEFVDHTHKLDEVSNTFLWGFDSNNWRLLLQIYTDPENGIVEMLNDMKSI 132

HSP 2 Score: 114.39 bits (285), Expect = 1.690e-29
Identity = 59/69 (85.51%), Postives = 62/69 (89.86%), Query Frame = 3 
Query:  654 MLSVCANIFFNRIKTIAQYLKLTKSLANKNRFRWFTRVLENKEVYYIQFYIIPLMQNVSNVQRVRTFSK 860
            MLSVCANIFFNRIKTIAQYLKLTK+LANKNRFR FTRVLENKEV YIQ YIIPLMQNVSNVQ   + +K
Sbjct:    1 MLSVCANIFFNRIKTIAQYLKLTKNLANKNRFRLFTRVLENKEVCYIQCYIIPLMQNVSNVQNNSSDAK 69
The following BLAST results are available for this feature:
BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SKI2.611e-3440.51SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10... [more]
SKIL7.956e-3036.84SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
SKIL1.019e-2936.84SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
SKIL1.128e-2936.84SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
SKIL1.128e-2936.84SKI like proto-oncogene [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Snoo1.975e-3137.09gene:FBgn0085450 transcript:FBtr0343409[more]
Snoo1.975e-3137.09gene:FBgn0085450 transcript:FBtr0112717[more]
Snoo1.975e-3137.09gene:FBgn0085450 transcript:FBtr0112719[more]
Snoo1.975e-3137.09gene:FBgn0085450 transcript:FBtr0112718[more]
fuss1.505e-2032.39gene:FBgn0039932 transcript:FBtr0301336[more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
skila1.287e-3536.41SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GEN... [more]
skila2.623e-3536.41SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GEN... [more]
skia5.655e-3538.50v-ski avian sarcoma viral oncogene homolog a [Sour... [more]
skib8.270e-3540.30v-ski avian sarcoma viral oncogene homolog b [Sour... [more]
skila4.528e-3436.41SKI-like proto-oncogene a [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SKI3.646e-3235.87SKI proto-oncogene [Source:NCBI gene;Acc:100486949... [more]
ENSXETT00000042147.11.222e-2936.08SKI-like proto-oncogene [Source:NCBI gene;Acc:1004... [more]
arg15.466e-2232.09arginase 1 [Source:Xenbase;Acc:XB-GENE-966913][more]
SKOR11.798e-2131.58SKI family transcriptional corepressor 1 [Source:N... [more]
SKOR12.199e-2131.58SKI family transcriptional corepressor 1 [Source:N... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ski1.880e-3437.67ski sarcoma viral oncogene homolog (avian) [Source... [more]
Ski4.743e-3438.18ski sarcoma viral oncogene homolog (avian) [Source... [more]
Skil3.514e-3036.84SKI-like [Source:MGI Symbol;Acc:MGI:106203][more]
Skil4.935e-3036.84SKI-like [Source:MGI Symbol;Acc:MGI:106203][more]
Skil6.664e-3036.84SKI-like [Source:MGI Symbol;Acc:MGI:106203][more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P17863|SKI_AVIES3.772e-3436.10Transforming protein Ski OS=Avian erythroblastosis... [more]
sp|P12755|SKI_HUMAN1.254e-3340.51Ski oncogene OS=Homo sapiens OX=9606 GN=SKI PE=1 S... [more]
sp|Q60698|SKI_MOUSE1.278e-3337.67Ski oncogene OS=Mus musculus OX=10090 GN=Ski PE=1 ... [more]
sp|Q9TUG2|SKI_HORSE6.338e-3340.00Ski oncogene OS=Equus caballus OX=9796 GN=SKI PE=2... [more]
sp|P49140|SKI_CHICK1.204e-3240.21Ski oncogene OS=Gallus gallus OX=9031 GN=SKI PE=1 ... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A564YIS21.153e-4943.06c-SKI_SMAD_bind domain-containing protein OS=Hymen... [more]
A0A564YIK61.239e-4944.66c-SKI_SMAD_bind domain-containing protein OS=Hymen... [more]
A0A0R3SIW81.477e-4944.66c-SKI_SMAD_bind domain-containing protein OS=Hymen... [more]
A0A504YBK61.882e-4838.66c-SKI_SMAD_bind domain-containing protein OS=Fasci... [more]
A0A0R3VSN94.322e-4844.19c-SKI_SMAD_bind domain-containing protein OS=Taeni... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
skia1.455e-3235.15ski oncogene [Source:NCBI gene;Acc:103046211][more]
skib2.959e-3136.06ski oncogene-like [Source:NCBI gene;Acc:103031474][more]
skib3.840e-3136.06ski oncogene-like [Source:NCBI gene;Acc:103031474][more]
skila4.121e-3132.41SKI like proto-oncogene [Source:NCBI gene;Acc:1030... [more]
skilb1.028e-2733.16ski-like protein [Source:NCBI gene;Acc:103027845][more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000001301.11.802e-2230.11pep scaffold:Pmarinus_7.0:GL481803:9978:11426:-1 g... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO418369.628e-2937.28Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
skia3.195e-3539.91SKI proto-oncogene [Source:NCBI gene;Acc:101164645... [more]
skia4.141e-3539.91SKI proto-oncogene [Source:NCBI gene;Acc:101164645... [more]
skib5.949e-3440.72ski oncogene [Source:NCBI gene;Acc:101171238][more]
skila2.626e-3136.90SKI like proto-oncogene [Source:NCBI gene;Acc:1119... [more]
skor1b4.024e-2232.95SKI family transcriptional corepressor 1 [Source:N... [more]
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BLAST of c-SKI_SMAD_bind domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000018825.10.000e+096.93SMESG000018825.1[more]
SMESG000002232.11.240e-8371.58SMESG000002232.1[more]
SMESG000037051.14.846e-4962.86SMESG000037051.1[more]
SMESG000070642.18.631e-4139.15SMESG000070642.1[more]
SMESG000075612.11.226e-3791.30SMESG000075612.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025907 ID=SMED30025907|Name=c-SKI_SMAD_bind domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2806bp
GATCAATCGATCTAAATTTAATTACAGGCAGGCTAAAATAAGCTTCCTAA
AATATGAGTCGCGGCAATGAGCGAGTTGATTCCCTGATAGAAAATTGACG
CCTCAGACAAACCGCATGCACACACCAAACCAATGTGAGACAAATCTCTA
ACCAGGCAAGAGAATGTCTGTGAAAATGCATGCGTAACCTCTGCATATCG
ATATTTATTTAGCACACACACAGAGGGAGAACCAACCACCGATGTCCGAC
TTCGCTAGCCGCACCACACAGATTGTCATAACAATCTTCATTGGTCACTT
GAAAAATACCTACATGTTAGCTCTAATTTATACTTGGTAGTTCAATTGGC
ATTTATTGAAAAACCGCAAAACAAGAATGAGCATCGAAGTATTTGAGGAT
CCGGGTACTTTAGACTACAATATGATTGAAAATGAACTTATTGCTGGATT
TAATGTATGGGGCGAAAGAAGAATTTGTCTACCTCAATTATTAAGATTCG
TTTTACCAGAATTCGATATAAATGTAATAGATCAAGCTGTTACGGATTTG
AGAATAAATTGCTTTCAATGCAATAATCAACAAATCAAAATGTTGCATGA
TAATGAAATTTTTCCAAAGCACATTGTTCGATGTGGACTTATTCGTAAAA
GTGATGCTGAGCGTTTGTGCAAATATCTTTTTCAACCGAATCAAAACTAT
AGCACAATATCTGAAGCTAACCAAAAGCTTAGCCAACAAGAATCGATTCA
GGTGGTTCACACGTGTTTTGGAGAACAAAGAGGTATATTATATCCAGTTT
TATATAATTCCTCTGATGCAAAATGTATCAAATGTGCAACGTGTGAGAAC
TTTTTCAAAACATTTGAATTCGTTGGTCATACTCACAAATTAGATGAAGT
TTCAAACACTTTTCATTGGGGTTTCGATTCAAACAACTGGAGACTATTGT
TACAAATTTACACTGATCCAGAAAACGGCAATGTGGAAATGTTAAATGAT
AAGAAGTCAATTTTAGATAAAGTAAAAGCATTGTATTACGAGGATGAAAT
AAAGAAAAGAAATCAAACCAATATAAATCTCGTTTGGAGGCCCAGTCGGA
AATTTAAATTACCCAAACCCCCAAAACCGAATTTCAATAGTCCTAAACCA
CCTCACTTGAGAGATGGATTGGCTGATGTTTATCGAAAAACTTCAAACTC
TAGCCTTAATGTTTCGAAATTCGATAAATTGAGCAATAACAATTTTGTTC
CAAATGTTTATTTACAGCCTCCAGATGGAAACCTTGTAAATGCCGATACT
GGCAATGACGATGATGACATTGATGATTATGATGATTTCTCTGTTAAAGT
GATTAAGTGTCCAAATGATCCGGCAATGAATGCGGCATTACAGATTAAAA
AGGAATCTGTAAACAAAGATGGTTTGAGCCTTGGAACAATAAGTGCTTTT
CTTAATAAGAAAGAGTTCACAAATATCAATCACAATGAACAACCAAATAA
TAGTAATAATAATAATAATAAATTTGGGAAACATGAAAATGGATTAGTTA
TTGTTGCTCAATCAGCTACCAGTATTCCACCCCAGTTTTTGATGTTAGAG
GCTTTGTGGTCTCAATTGTTTCGAGATATAATTCAATTAACACATCTTGT
CCATTTCAATACGAACGATGAGCGCAATCGAATTGTCGGGCAGTTGATGC
GATGTCAGGATCTTTTCAGGACACAATGGGCAGATTTGGCTGAAGAAAAT
CAGTTATTAAAAGAAAAATTATTCCAAGAACAAAACCGACGGCAAGAAAT
CGAAAATCTTCACGAAAAAATGAGCATCTCATTAAAGGAGTTGACAATGG
AAAAGAGCAATTTAAATGAAATAATTAAGCAACTGGAATCTGAATGTGAA
AAACTGCGTTCAGAAATTAAACCATTTATTGAGTCTGAACGTTTAATGGA
TTCAGCAATGAATAAAGATTCTCAGAAACCAGATTCGAATATTGAAATTG
AAGTTTACAATTGGTGTCGAGCTGGGTGCAAGCGAAATCGTAGCGGCAGT
AGCTCAGACGAATCTGAGCATCAGCAGCGCCAATTTCACAATCACCATCA
CTTCATTAGTGCTCATGGTAGTGACAGGGCGGATTTGTCAGACAAACCGA
CGAGCAGTTGTAAACAAATGAGACTTTCAACGACCGAGAAAAAATTATTG
GGTGGTAGCGGCATTAATGTGGATGTTAATGATAATTTCGTCATTGTCCC
TACTAATATTAATGATAATGAGTCACAATGAATTGGGGAGAACGGTCCTA
CTCACGACTAAATAAAACAACAATAAATTTACTATATCTCATGAACAAAT
TGTTTGAATGTCTTGTCTGCCTGACTGACTATCTACTATCTTTCATCCAT
ATGCTACCTGATTAATATTTGTAAATTTACTACTGTCTGTTCTTCTCATG
CTTTTATTTCATTTTAGGGATTCCTCATTTGTATTTTATTCGCTTGTATT
ACAACAAAAACCTATTGCCACCACTGAGGTGATTAATTAATGAACAAATT
TCAATCAAGCTATTACTATTATTATTACTATTATTATTATATTTTGTTAC
TTCCACATGAAACCATTTACTTCATTTCTTAGATATATAATGGTTTTAGG
TGCATTGGTGAGAAACAGAGCGATATTATCTTGTTGATATTAATATTATT
ATTTATGATGTCATCATGGTAATTTCATTGGTTGATTGTATTGCTTTCAA
TTGTAACATATATTGTTCGTTGATTAATTTCTTTTTAAAATAAATTTATT
TCTTTT
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protein sequence of SMED30025907-orf-1

>SMED30025907-orf-1 ID=SMED30025907-orf-1|Name=SMED30025907-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=635bp
MSIEVFEDPGTLDYNMIENELIAGFNVWGERRICLPQLLRFVLPEFDINV
IDQAVTDLRINCFQCNNQQIKMLHDNEIFPKHIVRCGLIRKSDAERLCKY
LFQPNQNYSTISEANQKLSQQESIQVVHTCFGEQRGILYPVLYNSSDAKC
IKCATCENFFKTFEFVGHTHKLDEVSNTFHWGFDSNNWRLLLQIYTDPEN
GNVEMLNDKKSILDKVKALYYEDEIKKRNQTNINLVWRPSRKFKLPKPPK
PNFNSPKPPHLRDGLADVYRKTSNSSLNVSKFDKLSNNNFVPNVYLQPPD
GNLVNADTGNDDDDIDDYDDFSVKVIKCPNDPAMNAALQIKKESVNKDGL
SLGTISAFLNKKEFTNINHNEQPNNSNNNNNKFGKHENGLVIVAQSATSI
PPQFLMLEALWSQLFRDIIQLTHLVHFNTNDERNRIVGQLMRCQDLFRTQ
WADLAEENQLLKEKLFQEQNRRQEIENLHEKMSISLKELTMEKSNLNEII
KQLESECEKLRSEIKPFIESERLMDSAMNKDSQKPDSNIEIEVYNWCRAG
CKRNRSGSSSDESEHQQRQFHNHHHFISAHGSDRADLSDKPTSSCKQMRL
STTEKKLLGGSGINVDVNDNFVIVPTNINDNESQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000101muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR037000Ski_DNA-bd_sf
IPR023216Tscrpt_reg_SKI_SnoN
IPR014890c-SKI_SMAD4-bd_dom
IPR010919SAND-like_dom_sf
IPR003380SKI/SNO/DAC
IPR009061DNA-bd_dom_put_sf
Vocabulary: molecular function
TermDefinition
GO:0046332SMAD binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 458..513
NoneNo IPR availablePANTHERPTHR10005:SF25SNO ONCOGENE, ISOFORM Bcoord: 16..351
IPR014890c-SKI SMAD4-binding domainSMARTSM01046c_SKI_SMAD_bind_2coord: 123..221
e-value: 1.4E-22
score: 91.0
IPR014890c-SKI SMAD4-binding domainPFAMPF08782c-SKI_SMAD_bindcoord: 123..218
e-value: 4.6E-25
score: 87.7
IPR003380SKI/SNO/DAC domainPFAMPF02437Ski_Snocoord: 11..101
e-value: 1.3E-29
score: 102.1
IPR037000Ski-like, DNA-binding domain superfamilyGENE3DG3DSA:3.10.260.20coord: 11..106
e-value: 1.4E-28
score: 100.6
IPR010919SAND-like domain superfamilyGENE3DG3DSA:3.10.390.10coord: 121..221
e-value: 8.6E-27
score: 95.1
IPR010919SAND-like domain superfamilySUPERFAMILYSSF63763SAND domain-likecoord: 123..201
IPR023216Transcription regulator SKI/SnoNPANTHERPTHR10005SKI ONCOGENE-RELATEDcoord: 16..351
IPR009061Putative DNA-binding domain superfamilySUPERFAMILYSSF46955Putative DNA-binding domaincoord: 10..101